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Histiocytic necrotizing lymphadenitis

Diego F Baenas, Fernando A Diehl, María J Haye Salinas, Verónica Riva, Ana Diller, Pablo A Lemos
Kikuchi-Fujimoto disease, or histiocytic necrotizing lymphadenitis, is an infrequent idiopathic disorder. It has been associated with autoimmune disorders, of which systemic lupus erythematosus is the most outstanding. The basis of its diagnosis relies on the histological examination of lymph nodes, which typically reveals necrosis surrounded by histiocytes with crescentic nucleus, immunoblasts and plasma cells, and absence of neutrophils. We report the case of a 27-year-old Argentinian female patient without any relevant past medical history to demonstrate the correlation between Kikuchi-Fujimoto disease and systemic lupus erythematosus...
2016: International Medical Case Reports Journal
Arvind P Ganpule, Jaspreet Singh Chabra, Abhishek G Singh, Gopal R Tak, Shailesh Soni, Ravindra Sabnis, Mahesh Desai
Kikuchi-Fujimoto disease (KFD) is an extremely rare disease with a worldwide distribution and higher prevalence in Asians. It is a benign and self-limiting disorder, characterized by regional cervical lymphadenopathy accompanied with mild fever and night sweats. Lymph node histopathology is diagnostic and treating physicians should be aware of this entity as it may mimic other systemic diseases like systemic lupus erythematosus, tuberculosis, malignant lymphoma, and more rarely adenocarcinoma. Key features on lymph node biopsy are fragmentation, necrosis and karyorrhexis...
2016: F1000Research
Tetsuya Tabata, Katsuyoshi Takata, Tomoko Miyata-Takata, Yasuharu Sato, Shin Ishizawa, Tomoyoshi Kunitomo, Keina Nagakita, Nobuhiko Ohnishi, Kohei Taniguchi, Mai Noujima-Harada, Yoshinobu Maeda, Mitsune Tanimoto, Tadashi Yoshino
INTRODUCTION: Histiocytic necrotizing lymphadenitis (or Kikuchi-Fujimoto disease) frequently occurs in Asian young adult females and typically presents as cervical lymphadenopathy with unknown etiology. Although large immunoblasts frequently appear in Kikuchi-Fujimoto disease, the diffuse infiltration of these cells can cause difficulty in establishing a differential diagnosis from lymphoma. In such cases, CD30 immunostaining may be used; however, the extent or distribution pattern of CD30-positive cells in Kikuchi-Fujimoto disease remains largely unknown...
July 6, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Maria Luisa Fiorella, Matteo Gelardi, Andrea Marzullo, Elena Sabattini, Raffaele Fiorella
Kikuchi-Fujimoto's disease (KFD) is a rare, benign condition characterized by histiocytic necrotizing lymphadenitis predominantly in the cervical region and prolonged fever. It has a higher prevalence in the Japanese and Asian populations although it may be seen in a wide geographic distribution, but rare are the cases reported in Europe. While symptoms resolve spontaneously between 2 weeks and 2 months, complications are described in: CNS, eyes, respiratory tract, kidney and liver. KFD also described an association with systemic lupus erythematosus...
June 17, 2016: European Archives of Oto-rhino-laryngology
Rohit Kataria, Pankaj Rao, Dilip Kachhawa, Vinod K Jain, Rajat K Tuteja, Manish Vijayvargiya
Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a rare, benign, self-limiting disease with unknown etiology characterized by regional lymphadenopathy. A 30-year-old female presented with fever, weakness, multiple joint pain, oral ulcers, erythematous facial rashes, hemorrhagic crusting on both lips, and cervical lymphadenopathy of 2-month duration. Clinically, the disease was mimicking systemic lupus erythematosus, but immunofluorescence was negative for it. Lymph node biopsy suggested a diagnosis of KFD...
May 2016: Indian Journal of Dermatology
P Błasiak, M Jeleń, A Rzechonek, M Marciniak, K Pawełczyk, J Cianciara, J Kołodziej, B Muszczyńska-Bernhard
Kikuchi Fujimoto disease (KFD) as a rare self-limiting lymphadenopathy of short and benign course concerns most frequently the lymph nodes of the neck. The most common symptoms are painfulness of the diseased area, fever and night sweating. The etiology is not well understood, but in the role of pathogenesis viral, autoimmune and genetic factors are taken into account. In the presented case of 37-year-old female it was necessary to exclude diseases such as lymphoma or thymoma because of atypical mediastinal location of Kikuchi Fujimoto disease...
March 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
R Bakir, A-L Lecapitaine, J Chevalier, B Juberthie, M-A Bouldouyre, H Gros
INTRODUCTION: The histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto's disease is characterized by a lymph node inflammation whose similarity with systemic lupus is generally admitted. CASE REPORT: Our description of two familial cases aims at raising the hypothesis of the existence of a genetic background in this disease following the example of what is observed in the autoimmune diseases. CONCLUSION: Pathophysiology of Kikuchi-Fujimoto's disease is probably multifactorial and may include predisposing genetic background and a possible infectious triggering event...
February 19, 2016: La Revue de Médecine Interne
Hua Du, Yonghong Shi, Yingxu Shi
OBJECTIVE: To study the clinical manifestation, pathologic features and immunophenotype of histiocytic necrotizing lymphadenitis (HNL). METHODS: The clinicopathologic data of 84 patients with HNL from 2005 to 2014 were retrospectively studied. Immunohistochemical staining using EliVision method for CD20, PAX5, CD3, CD45RO, CD4, CD8, CD56, CD68, CD123, granzyme-B, TIA1 and MPO was carried out. In-situ hybridization for Epstein-Barr virus RNA was performed on archival lymph node biopsy tissue...
February 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Hyun Mi Kang, Ji Young Kim, Eun Hwa Choi, Hoan Jong Lee, Ki Wook Yun, Hyunju Lee
OBJECTIVES: To analyze the clinical characteristics of children with Kikuchi-Fujimoto disease focusing on cases with prolonged fever. STUDY DESIGN: This was a retrospective study of children diagnosed with Kikuchi-Fujimoto disease from March 2003 to February 2015 in South Korea. Electronic medical records were searched for clinical and laboratory manifestations. RESULTS: Among 86 histopathologically confirmed cases, the mean age was 13.2 (SD ± 3...
April 2016: Journal of Pediatrics
Mozaffar Aznab, Naser Kamalian, Jaffar Navabi, Kaveh Kavianimoghadam
Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is an idiopathic, self-limiting disorder and predominantly affects young women. We report a 35-year-old female who presented with soft to firm cervical lymphadenopathy and neck pain. She had multiple enlarged cervical nodes. Examination of other systems was normal. Lymph node biopsy was performed, and the histological features, and immunohistochemistry confirmed the diagnosis. The Patient was treated with non-steroidal anti-inflammatory drugs and low-dose prednisolone...
November 2015: Acta Medica Iranica
Jun Zhang, Jun Yang, Wan-Wen Weng, Yang-Jun Zhu, Hong Qiu, Meng-Jie Dong
Kikuchi-Fujimoto disease (KFD), known as subacute necrotizing histiocytic lymphadenitis, is an extremely rare, benign and self-limited disease, and has been infrequently reported with autoimmune diseases. Here we report a 17-year-old girl pathologically diagnosed as KFD who suffered recurrence of KFD and developed into Sjogren's syndrome (SS) after four years and then performed a systematic literature search about KFD associated with SS in which seven patients was reviewed in detail. The results show that SS may be prior to, simultaneous with or following KFD and it developed mainly in young (average age: 25 years), female patients (4/5) after KFD with an average latency of 43 months...
2015: International Journal of Clinical and Experimental Medicine
Hiroko Sato, Shigeyuki Asano, Kikuo Mori, Kazuki Yamazaki, Haruki Wakasa
We confirmed the characteristic clinical features of necrotizing lymphadenitis (NEL) in 66 cases (23 male, 43 female) in Japan, which included high fever (38-40°), painful cervical lymphadenopathy (62/66, 93.9%), and leukopenia (under 4,000/mm(3)) (25/53, 47.2%), without seasonal occurrence, in a clinicopathological, immunohistochemical, electron microscopic serological study. Patient age varied from 3-55 years, and 72.7% (44/66) of patients were younger than 30 years. Histopathology of NEL was characterized by the presence of CD8(+) immunoblasts, CD123(+) cells (plasmacytoid dendritic cells; PDCs), histiocytes and macrophages phagocytizing CD4(+) apoptotic lymphocytes, but no granulocytes or bacteria...
2015: Journal of Clinical and Experimental Hematopathology: JCEH
Jie Xu, Heather H Sun, Christopher D M Fletcher, Jason L Hornick, Elizabeth A Morgan, Gordon J Freeman, F Stephen Hodi, Geraldine S Pinkus, Scott J Rodig
Programmed cell death 1 ligands 1 and 2 (PD-L1 and PD-L2) are cell surface proteins expressed by activated antigen-presenting cells and by select malignancies that bind PD-1 on T cells to inhibit immune responses. Antibodies targeting PD-1 or PD-L1 elicit antitumor immunity in a subset of patients, and clinical response correlates with PD-1 ligand expression by malignant or immune cells within the tumor microenvironment. We examined the expression of PD-1 ligands on subsets of antigen-presenting cells and 87 histiocytic and dendritic cell disorders including those that are benign, borderline, and malignant...
April 2016: American Journal of Surgical Pathology
F Andriamampionona Tsitohery, V F Ranaivomanana, O Laza, N S Randrianjafisamindrakotroka
Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a rare and unfamiliar clinicopathological entity characterized by cervical lymphadenopathy, often associated with systemic signs such fever and night sweats. We report the first three Malagasy cases of Kikuchi-Fujimoto disease, diagnosed at the Pathology Lab of Joseph Ravoahangy Andrianavalona Hospital, occurring in three female patients of 11, 19 and 35 years old. The clinical course mimicked lymphoma in one case and tuberculosis in two cases...
October 2015: Médecine et Santé Tropicales
J Magutová
We report the case of a 29-year-old Turkish woman who was admitted to hospital with a 4-week history of fever up to 39.0 °C, headache, sore throat, fatigue and painful cervical and right-sided axillary lymph node swelling. Computed tomography imaging of the neck, thorax and abdomen identified generalized but in particular bilateral cervical and right-sided axillary lymph node enlargement (up to 2 cm). The histological examination of the axillary lymph node biopsy revealed Kikuchi-Fujimoto disease (KFD), a condition characterized by histiocytic necrotizing lymphadenitis...
January 2016: Der Internist
Nobuhito Naito, Tsutomu Shinohara, Hisanori Machida, Hiroyuki Hino, Keishi Naruse, Fumitaka Ogushi
INTRODUCTION: Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare entity of unknown etiology in young adults that is typically characterized by cervical lymphadenopathy and persistent fever. The pathogenesis of KFD has been suggested to be an abnormal immune response, and infections or autoimmune diseases are considered to be involved in KFD. However, KFD associated with community acquired pneumonia (CAP) has not been reported. CASE DESCRIPTION: A 35-year-old male was admitted due to high fever, diffuse air-space consolidation in the right lung with ipsilateral pleural effusion and massive mediastinal and hilar lymphadenopathy without cervical lesions...
2015: SpringerPlus
Na He, Sheng-Quan Cheng, Wei Yan, Xiao-Ning Chen
No abstract text is available yet for this article.
November 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Christine E Jabcuga, Long Jin, William R Macon, Matthew T Howard, Andre M Oliveira, Rebecca L King
Bartonella henselae lymphadenitis, or cat-scratch lymphadenitis (CSL), is classically associated with stellate microabscesses, occasional giant cells, and extension of the inflammatory infiltrate into perinodal soft tissue. Availability of B. henselae molecular testing on tissue specimens has broadened our understanding of the morphologic variation in this disease. Here we sought to describe the histopathologic features of the largest series to date of molecularly proven CSL. B. henselae polymerase chain reaction-positive tissue specimens from 2010 to 2012 were identified, and hematoxylin and eosin slides were reviewed...
March 2016: American Journal of Surgical Pathology
Marina Vaz, Carmen M Pereira, Sindhoora Kotha, Jamina Oliveira
Kikuchi's disease is a rare condition that mainly presents in young females along with lymphadenitis. Involvement of the nervous system is rare. We report a young female who presented with fever, headache, vomiting, lymphadenopathy and neurological manifestations in the form of aseptic meningitis, ataxia and paraparesis. Since the disease can be mistaken clinically and histologically for SLE, lymphoma and tuberculosis it is important to differentiate it from these conditions. Also our case emphasizes the importance of recognising this disorder in diagnosing patients with meningitis...
November 2014: Journal of the Association of Physicians of India
Shailesh Garg, Manuel Villa, Jaya Ruth Asirvatham, Thomas Mathew, Louis-Joseph Auguste
Kikuchi-Fujimoto disease also known as histiocytic necrotizing lymphadenitis is a rare cervical inflammatory lymphadenitis that is most commonly seen in young Asian women. It is mainly characterized by lymphadenopathy, hepatosplenomegaly, fever, nocturnal sweats, myalgia, weight loss, and arthralgia, and commonly follows a self-limited course. The differential diagnosis is challenging as many other conditions such as malignant lymphoma, metastatic disease, tuberculosis and infectious lymphadenopathies can present in a similar way...
June 2015: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
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