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Histiocytic necrotizing lymphadenitis

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https://www.readbyqxmd.com/read/29755898/an-unusual-presentation-of-kikuchi-fujimoto-disease-with-recurrent-subdural-effusion
#1
Sara Shahid, Syed H Alam, Indira Hadley
A 24-year-old man complained of a right temporal headache for four weeks. The patient denied any trauma or previous anticoagulation use. He also reported tender right facial swelling. His physical exam was unrevealing except for right cranial nerve (CN) VI palsy, right parotid enlargement, and cervical adenopathy. Laboratory findings were significant for mild leukopenia at 3300 cells/uL. The computed tomography (CT) scan obtained showed a chronic left subdural effusion with a 4 mm midline shift and confirmed right parotid enlargement and cervical lymphadenopathy...
March 10, 2018: Curēus
https://www.readbyqxmd.com/read/29567898/kikuchi-s-disease-histiocytic-necrotizing-lymphadenitis-a-rare-presentation-with-acute-kidney-injury-peripheral-neuropathy-and-aseptic-meningitis-with-cutaneous-involvement
#2
Jyoti Jain, Shashank Banait, Iadarilang Tiewsoh, Madhura Choudhari
Kikuchi's disease (KD) also known as histiocytic necrotizing lymphadenitis is rare, idiopathic, generally self-limited cause of lymphadenitis. We present a case of twenty year young female who presented in critically ill state with fever, cervical and axillary lymphadenopathy, rash, vomiting and altered sensorium and found to have neurological, hepatic, renal and dermatological involvement. Kikuchi's disease should be considered in differential diagnosis of fever and lymphadenopathy and though benign can sometimes present with multi-organ involvement...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29290321/-kikuchi-disease-evolution-during-outbreaks-and-its-response-to-antimalarial-treatment
#3
David Castro Corredor, Isabel María de Lara Simón, David Bellido Pastrana
Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a syndrome characterized by the presence of usually painful cervical lymphadenopathy with fever and night sweats. It is a rare clinical entity that mainly affects young Asian women, although it found worldwide. It is a benign and self-limiting condition; however, its importance lies in its differential diagnosis with other clinical entities such as lymphoma or histiocytoma. We present a case of Kikuchi-Fujimoto disease, with special emphasis on its clinicopathological significance and its evolution during outbreaks...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29246252/fever-with-lymphadenopathy-kikuchi-fujimoto-disease-a-great-masquerader-a-case-report
#4
Chamara Dalugama, Indika Bandara Gawarammana
BACKGROUND: Kikuchi Fujimoto disease is an uncommon benign condition of necrotizing histiocytic lymphadenitis commonly seen in East Asian and Japanese populations. It commonly presents with fever, cervical lymphadenopathy, and elevated inflammatory markers. Diagnosis of Kikuchi Fujimoto disease is based on histopathological studies of the involved lymph nodes. The presentation of Kikuchi Fujimoto disease can mimic many sinister conditions including lymphoma. Treatment is mainly supportive provided that accurate diagnosis is made and sinister conditions like lymphoma ruled out...
December 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29108510/a-mimic-of-posttransplant-lymphoproliferative-disease-following-liver-transplant
#5
William H Kitchens, David L Jaye, Joel P Wedd, Joseph F Magliocca
Generalized lymphadenopathy after organ transplant is a concerning finding, often indicating the devel-opment of lymphoma. We describe a 52-year-old liver transplant recipient who had clinical symptoms and imaging concerning for posttransplant lymphoproliferative disease. However, histologic evaluation of a lymph node biopsy revealed that the patient actually had a much rarer but relatively benign condition, Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis). We discuss the epidemiology, clinical symptoms, diagnosis, histologic features, and treatment of this uncommon mimic of posttransplant lymphoproliferative disease...
October 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28904672/-kikuchi-fujimoto-disease-about-a-case
#6
Sanaa Elfihri, Mustapha Laine, Fouad Kettani, Jaouda Ben Amor, Jamel Eddine Bourkadi
Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a rare cause of benign cervical adenopathies. It is an anatomoclinic entity of unknown cause. Diagnosis is based on histologic examination of the lymph nodes. Patient's evolution is generally favorable with spontaneous healing after a few weeks. We here report the case of a 9-year old girl presenting with cervical lymphadenopathy associated with fever. Cervical lymph node biopsy showed Kikuchi-Fujimoto disease. Patient's evolution was marked by regression of adenopathies without receiving any treatment...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28806027/a-rare-case-of-lymphadenopathy-kikuchi-fujimoto-disease
#7
Josh Rezkalla, Douglas W Lynch
A relatively unknown cause of cervical lymphadenopathy is Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis. This is a rare and benign condition that presents with painful cervical lymphadenopathy, fevers, night sweats, and weight loss. This disease is most prevalent in Asian women between the age of 20-35 years. The diagnosis of Kikuchi Disease is made histologically and is characterized by paracortical areas of necrosis and a notable complete absence of neutrophils. The painful lymphadenopathy can be simply treated with antipyretics, but due to its presenting symptoms of Kikuchi disease, it is often mistaken for malignant lymphoma...
July 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28767989/report-of-a-rare-case-of-histiocytic-necrotizing-lymphadenitis-with-bilateral-pleural-effusion-diagnosed-via-cervical-lymph-node-biopsy
#8
Xuchun Liu, Shubin Huang, Guohua Jiang
CONTEXT: Histiocytic necrotizing lymphadenitis (HNL) is a rare disorder that is often benign and self-limiting. There have been reports of co-occurrence of HNL with other diseases, including systemic lupus erythematosus, hemophagocytic syndrome and antiphospholipid syndrome. CASE REPORT: Here, we report a case in which a patient experienced unexplained fever, swelling of the cervical lymph node and bilateral pleural effusion and was ultimately diagnosed with HNL based on results from a lymph node biopsy...
July 31, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28693162/kikuchi-fujimoto-disease-in-the-regional-lymph-nodes-with-node-metastasis-in-a-patient-with-tongue-cancer-a-case-report-and-literature-review
#9
Tessho Maruyama, Kazuhide Nishihara, Masanao Saio, Toshiyuki Nakasone, Fumikazu Nimura, Akira Matayoshi, Takahiro Goto, Naoki Yoshimi, Akira Arasaki
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare self-limiting disorder typically affecting the cervical lymph nodes (LNs), which is often misdiagnosed as other LN-associated diseases. KFD frequently presents with necrotic lesions and recurrences, which are also features of metastatic LNs. Clinicians may thus suspect LN metastasis when they encounter ipsilateral cervical lymphadenopathy in a patient with head and neck cancer. The present study reports the case of a 48-year-old man with tongue cancer and KFD affecting the right edge of his tongue and ipsilateral cervical LNs...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28638624/kikuchi-fujimoto-disease-a-case-report-of-a-multi-drug-resistant-grueling-disease
#10
Alexey Youssef, Rahaf Ali, Kinan Ali, Zuheir AlShehabi
Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto disease (KFD) is characterized by its rare occurrence. Mostly prevalent among Asian women, KFD manifests with lymphadenopathy-affecting mostly cervical and rarely generalized or retroperitoneal regions-in addition to fever. It is a self-limited disease that resolves within 1-4 months, responding remarkably to glucocorticosteroids or hydroxychloroquine. However, some rare cases prove to be unresponsive to the previously mentioned therapies. Here is a description of a case of KFD affecting a 67-year-old Syrian woman with a history of hypothyroidism due to iodine-deficiency...
June 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28365190/-kikuchi-fujimoto-disease-mimicking-malignant-lymphoma-in-adolescents
#11
A Escudier, S Courbage, V Meignin, S Abbou, S Sauvion, M Houlier, A Galerne, J Gaudelus, L de Pontual, M Simonin
Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a rare cause of lymphadenopathy in children. This benign disease can mimic lymphoma and misleads doctors. It was first described in Asia, where it occurred especially in young women. Recent publications show that it can also affect teenagers and young adults in Caucasian populations. The pathophysiology remains unknown. Three hypotheses have been raised for this disease: the role of viruses (in particular HHV-8), genetic predisposition (two alleles in HLA class II genes were found more frequently in patients with Kikuchi disease), and an autoimmune cause because of the correlation with lupus erythematosus...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28279633/kikuchi-fujimoto-disease-a-rare-cause-of-lymphadenopathy-in-africa-description-of-the-first-case-in-senegal-and-review-of-the-literature
#12
C-A Lame, B Loum, A-K Fall, J Cucherousset, A-R Ndiaye
INTRODUCTION: Kikuchi-Fujimoto disease, or histiocytic necrotizing lymphadenitis, is a benign disease most commonly affecting adult females. It generally presents in the form of febrile cervical lymphadenopathy. This diagnosis must be considered in the setting of tropical medicine, dominated by a high prevalence of tuberculous lymphadenitis and haematological malignancies. CASE REPORT: The authors report the case of a 33-year-old Senegalese woman who presented with subacute cervical lymphadenopathy associated with fever and laboratory signs of inflammation...
October 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28255545/fatality-in-kikuchi-fujimoto-disease-a-rare-phenomenon
#13
Bianca Barbat, Ruby Jhaj, Daniyeh Khurram
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is an uncommon condition, typically characterized by lymphadenopathy and fevers. It usually has a benign course; however, it may progress to fatality in extremely rare occasions. The diagnosis is made via lymph node biopsy and histopathology. Our patient was a young female who presented with shortness of breath, fever, and malaise. Physical examination revealed significant cervical and axillary lymphadenopathy. Chest X-ray displayed multilobar pneumonia...
February 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28195263/kikuchi-fujimoto-disease-a-clinicopathologic-update
#14
REVIEW
F Pepe, S Disma, C Teodoro, P Pepe, G Magro
Kikuchi-Fujmoto disease (KFD), also known as "histiocytic necrotizing lymphadenitis", is a rare lymphadenitis of unknown origin, but with an excellent prognosis. It is more common in Asia, but isolated cases are also reported in America, Africa and Europe. The disease can have an acute or subacute course, usually develops in 1 to 3 weeks, with spontaneous resolution in 1-4 months. The main clinical sign is cervical lymphadenopathy, especially in the posterior cervical triangle with bulky and painful lymph nodes, usually affecting only one side; rare cases of generalized lymphadenopathy can be seen...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28143446/kikuchi-fujimoto-disease-histiocytic-necrotizing-lymphadenitis-with-atypical-encephalitis-and-painful-testitis-a-case-report
#15
Hidenori Kido, Osamu Kano, Asami Hamai, Hiroyuki Masuda, Yutaka Fuchinoue, Masaaki Nemoto, Chiaki Arai, Teppei Takeda, Fumihito Yamabe, Toshihiro Tai, Mizuki Kasahara, Kenichi Suzuki, Nobuyuki Shiraga, Sota Sadamoto, Megumi Wakayama, Yukitoshi Takahashi, Yasuo Iwasaki, Kazutoshi Shibuya, Yoshihisa Urita
BACKGROUND: Kikuchi-Fujimoto disease is a self-limited clinicopathologic entity that is increasingly recognized worldwide. Kikuchi-Fujimoto disease is characterized by cervical lymphadenopathy occurring in young adults. Neurologic involvement is rare, and testitis directly caused by Kikuchi-Fujimoto disease has not yet been reported. CASE PRESENTATION: A 19-year-old man was brought to our clinic with complaints of fever, headache, fatigue, and left lower quadrant pain that had persisted for 3 weeks...
February 1, 2017: BMC Neurology
https://www.readbyqxmd.com/read/27904829/systemic-kikuchi-fujimoto-disease-bordering-lupus-lymphadenitis-a-fresh-look
#16
Aram Behdadnia, Seyyed Farshad Allameh, Mehrnaz Asadi Gharabaghi, Seyed Reza Najafizadeh, Ahmad Tahamoli Roudsari, Alireza Ghajar, Morsaleh Ganji, Mohsen Afarideh
A 31-year old woman with persistent fever for 6 weeks and unresponsive to antibiotic therapy came for rheumatologic investigation. After computed tomography (CT) studies of her neck, thorax and abdomen revealed bilateral cervical, axillary and retroperitoneal lymph node enlargements, histopathologic evaluation of the resected nodes showed features of histiocytic necrotizing lymphadenopathy suggestive of Kikuchi-Fujimoto's lymphadenopathy. Kikuchi-Fujimoto Disease (KFD) involving the retroperitoneal nodes is extremely unusual and even more challenging to diagnose when there are no early signs of extranodal involvement or abdominopelvic pain...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27418858/kikuchi-fujimoto-disease-and-systemic-lupus-erythematosus
#17
Diego F Baenas, Fernando A Diehl, María J Haye Salinas, Verónica Riva, Ana Diller, Pablo A Lemos
Kikuchi-Fujimoto disease, or histiocytic necrotizing lymphadenitis, is an infrequent idiopathic disorder. It has been associated with autoimmune disorders, of which systemic lupus erythematosus is the most outstanding. The basis of its diagnosis relies on the histological examination of lymph nodes, which typically reveals necrosis surrounded by histiocytes with crescentic nucleus, immunoblasts and plasma cells, and absence of neutrophils. We report the case of a 27-year-old Argentinian female patient without any relevant past medical history to demonstrate the correlation between Kikuchi-Fujimoto disease and systemic lupus erythematosus...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27408688/case-report-kikuchi-fujimoto-disease-a-diagnostic-and-therapeutic-dilemma-following-pretransplant-nephrectomy-for-a-2-35-kg-kidney
#18
Arvind P Ganpule, Jaspreet Singh Chabra, Abhishek G Singh, Gopal R Tak, Shailesh Soni, Ravindra Sabnis, Mahesh Desai
Kikuchi-Fujimoto disease (KFD) is an extremely rare disease with a worldwide distribution and higher prevalence in Asians. It is a benign and self-limiting disorder, characterized by regional cervical lymphadenopathy accompanied with mild fever and night sweats. Lymph node histopathology is diagnostic and treating physicians should be aware of this entity as it may mimic other systemic diseases like systemic lupus erythematosus, tuberculosis, malignant lymphoma, and more rarely adenocarcinoma. Key features on lymph node biopsy are fragmentation, necrosis and karyorrhexis...
2016: F1000Research
https://www.readbyqxmd.com/read/27389558/characteristic-distribution-pattern-of-cd30-positive-cytotoxic-t-cells-aids-diagnosis-of-kikuchi-fujimoto-disease
#19
Tetsuya Tabata, Katsuyoshi Takata, Tomoko Miyata-Takata, Yasuharu Sato, Shin Ishizawa, Tomoyoshi Kunitomo, Keina Nagakita, Nobuhiko Ohnishi, Kohei Taniguchi, Mai Noujima-Harada, Yoshinobu Maeda, Mitsune Tanimoto, Tadashi Yoshino
INTRODUCTION: Histiocytic necrotizing lymphadenitis (or Kikuchi-Fujimoto disease) frequently occurs in Asian young adult females and typically presents as cervical lymphadenopathy with unknown etiology. Although large immunoblasts frequently appear in Kikuchi-Fujimoto disease, the diffuse infiltration of these cells can cause difficulty in establishing a differential diagnosis from lymphoma. In such cases, CD30 immunostaining may be used; however, the extent or distribution pattern of CD30-positive cells in Kikuchi-Fujimoto disease remains largely unknown...
July 6, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27317565/kikuchi-fujimoto-disease-an-uncommon-cause-of-neck-swelling
#20
Maria Luisa Fiorella, Matteo Gelardi, Andrea Marzullo, Elena Sabattini, Raffaele Fiorella
Kikuchi-Fujimoto's disease (KFD) is a rare, benign condition characterized by histiocytic necrotizing lymphadenitis predominantly in the cervical region and prolonged fever. It has a higher prevalence in the Japanese and Asian populations although it may be seen in a wide geographic distribution, but rare are the cases reported in Europe. While symptoms resolve spontaneously between 2 weeks and 2 months, complications are described in: CNS, eyes, respiratory tract, kidney and liver. KFD also described an association with systemic lupus erythematosus...
March 2017: European Archives of Oto-rhino-laryngology
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