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Haemovigilance

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https://www.readbyqxmd.com/read/28345172/international-prospective-haemovigilance-study-on-methylene-blue-treated-plasma
#1
L Noens, Ma D Vilariño, A Megalou, H Qureshi
BACKGROUND AND OBJECTIVES: Methylene blue is a phenothiazine dye, which in combination with visible light has virucidal and bactericidal properties, disrupting the replication of a broad range of enveloped viruses and some non-enveloped viruses. The study objective was to collect data on adverse reactions occurring with methylene blue plasma administered in a routine clinical practice environment and document their characteristics and severity. MATERIALS AND METHODS: This was an open label, multicentre, non-controlled, non-randomized, non-interventional study...
March 26, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28151385/transfusion-associated-circulatory-overload-in-adult-medical-emergency-patients-with-perspectives-on-early-warning-practice-a-single-centre-clinical-study
#2
Fanny Gosmann, Astrid Nørgaard, Maj-Britt Rasmussen, Charlotte Rahbek, Jens Seeberg, Tom Møller
BACKGROUND: Transfusion-associated circulatory overload is characterised by acute respiratory distress, tachycardia, increased blood pressure, acute pulmonary oedema and/or evidence of positive fluid balance occurring within 6 hours after transfusion. Transfusion-associated circulatory overload is a serious, underreported reaction, which makes this iatrogenic condition difficult to prevent. We present an audit of patients admitted to a medical emergency unit, aiming to investigate: (i) the incidence of transfusion-associated circulatory overload; and (ii) whether cases were reported to the haemovigilance system...
January 26, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28139022/detection-of-adverse-events-of-transfusion-in-a-teaching-hospital-in-ghana
#3
A K Owusu-Ofori, S P Owusu-Ofori, I Bates
BACKGROUND AND OBJECTIVES: Monitoring the whole chain of events from the blood donors to recipients, documenting any undesirable or untoward effects and introducing measures to prevent their recurrence if possible are components of haemovigilance systems. Only few sub-Saharan African countries have haemovigilance systems, and there are very little data on adverse events of transfusion. Adverse events monitoring is an integral part of a haemovigilance system. Our study aimed to establish the incidence and types of adverse events of transfusions in Ghana and to identify interventions to improve effectiveness...
January 31, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28050389/haemovigilance-a-current-update-in-indian-perspective
#4
REVIEW
Somnath Mukherjee, Rituparna Maiti
Haemovigilance is an organised scheme of monitoring, identifying, reporting, investigating and analysing adverse events and reactions pertinent to transfusion and manufacturing blood products. This system is also an elemental part of quality control in a blood system, bringing about corrective and preventive measures, and for the perpetual advancement of the quality and safety of blood products and the transfusion process. Nowadays haemovigilance setups have been enforced throughout the globe in most developed countries, to monitor the adverse reactions and episodes associated with blood donations and transfusions...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28027853/a-haemovigilance-team-provides-both-significant-financial-and-quality-benefits-in-a-university-hospital
#5
Ine Decadt, Els Costermans, Maai Van de Poel, Katrien Kesteloot, Timothy Devos
BACKGROUND: Haemovigilance is the process of surveillance of blood transfusion procedures including unexpected hazards and reactions during the transfusion pathway in both donors and recipients. The haemovigilance team aims to increase blood transfusion safety and to decrease both morbidity and mortality in donors and recipients. The team collects data about transfusion reactions and incidents, instructs the involved health workers and assures the tracing of blood components. The haemovigilance team at the University Hospitals Leuven has played a pioneering role in the development of haemovigilance in Belgium Although the literature about safety and quality improvements by haemovigilance systems is abundant, there are no published data available measuring their financial impact in a hospital...
December 7, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28001313/incidence-and-clinical-characteristics-of-transfusion-associated-circulatory-overload-using-an-active-surveillance-algorithm
#6
N H Roubinian, J E Hendrickson, D J Triulzi, J L Gottschall, D Chowdhury, D J Kor, M R Looney, M A Matthay, S H Kleinman, D Brambilla, E L Murphy
BACKGROUND: The concordance of haemovigilance criteria developed for surveillance of transfusion-associated circulatory overload (TACO) with its clinical diagnosis has not been assessed. In a pilot study to evaluate an electronic screening algorithm, we sought to examine TACO incidence and application of haemovigilance criteria in patients with post-transfusion pulmonary oedema. STUDY DESIGN AND METHODS: From June to September 2014, all transfused adult inpatients at four academic hospitals were screened with an algorithm identifying chest radiographs ordered within 12 h of blood component release...
January 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28001310/the-association-of-fever-with-transfusion-associated-circulatory-overload
#7
N Parmar, J Pendergrast, L Lieberman, Y Lin, J Callum, C Cserti-Gazdewich
BACKGROUND: Fever is described in transfusion-associated circulatory overload (TACO), reflecting either comprehensive haemovigilance or an inflammatory pathobiology (such as congestion-associated atheroma disruptions). METHODS: Hospital haemovigilance data (1/1/2010-31/12/2012) were reviewed for TACO cases (frequency and mode of referral). TACO with or without fever (TACO+F/-F) was examined for its association with patient age (as a surrogate for atheroma burden) and product age (as a surrogate for storage-related pyrogens)...
January 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/27843110/-recipients-adverse-reactions-in-the-ibn-sina-hospital-of-rabat-state-1999-2013
#8
S Ouadghiri, C Brick, N Benseffaj, O Atouf, M Essakalli
PURPOSE OF STUDY: The declaration of the recipients adverse reactions (RAR) is one of the field haemovigilance activities. It provides an evaluation of transfusion side effects and thus prevents their appearance. The aim of this study is to analyze, over 14 years, the RAR supports reported in Rabat Ibn Sina hospital. PATIENTS AND METHODS: All of the RAR supports sending to the blood transfusion service were analyzed. The data collected from these supports are: clinical characteristics of the patient, type of incident observed and type of labile blood products (LBP) transfused...
February 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/27769684/-delayed-adverse-reactions-to-blood-donation-from-haemovigilance-data-to-specific-studies
#9
J-Y Py, S Durieux, M Barnoux, T Sapey
OBJECTIVES: Delayed adverse reactions to blood donation occur after the donor left donation site. Their intrinsic gravity and possible complications can be increased by the fact the donor is alone. This can also increase bad memories, leading to a donation giving up. Blood transfusion centre is only aware in case of donor feedback, hence an event underrating. We choose to compare our data upon delayed adverse donor reactions with those we could find in past studies. METHODS: A first data level comes from French haemovigilance data while serious adverse reactions declaration is mandatory...
November 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/27522103/unresolved-clinical-aspects-and-safety-hazards-of-blood-derived-ev-mv-in-stored-blood-components-from-personal-memory-lanes-to-newer-perspectives-on-the-roles-of-ev-mv-in-various-biological-phenomena
#10
REVIEW
Jerard Seghatchian, Jean Amiral
Blood cells generate heterogeneous populations of vesicles that are delivered, as small-specialized packages of highly active cell fragments in blood circulation, having almost similar functional activities, as the mother cells. These so called extracellular vesicles are the essential part of an energy-dependent natural apoptotic process; hence their beneficial and harmful biological functions cannot be ignored. Evidence is accumulating, that cellular derived vesicles, originate from all viable cells including: megakaryocytes, platelets, red blood cells, white blood cells and endothelial cells, the highest in proportions from platelets...
August 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27512480/rare-problems-with-rhd-immunoglobulin-for-postnatal-prophylaxis-after-large-fetomaternal-haemorrhage
#11
Amber Biscoe, Giselle Kidson-Gerber
We report a case of unusually large fetomaternal haemorrhage in a RhD- patient; of symptomatic non-sustained haemolysis of fetal red cells in the maternal circulation with infusion of intravenous high-dose RhD immunoglobulin; and of a failure to prevent RhD alloimmunisation. The haemolytic reaction is not previously reported in this patient group and we suggest would be limited to patients where the number of fetal red cells in the circulation is high. We advocate caution in treatment and spaced dosing of RhD immunoglobulin where the required dose is high, and refer readers to the WinRhoSDF™ RhD immunoglobulin product information for their updated dosing recommendations...
December 2015: Obstetric Medicine
https://www.readbyqxmd.com/read/27416567/acquired-red-blood-cell-alloantibodies-in-transfused-patients-of-80-years-or-over-a-2008-2013-national-haemovigilance-survey
#12
Pierre Moncharmont, Grégory Barday, Jean-Yves Py, Francis Meyer
BACKGROUND: As transfusion in the elderly patients has increased over the last decades, and with the aim of improving blood policy, post-transfusion red blood cell alloimmunisation, a delayed serological transfusion reaction, was investigated in patients 80 years old or over. MATERIAL AND METHODS: For every adverse reaction to a transfusion, a report is sent to the French haemovigilance database. All cases of red blood cell alloimmunisation reported in the haemovigilance database were collected, and an analysis was performed on those cases in transfused patients 80 years old or over...
July 5, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27111494/are-the-rules-for-times-in-set-up-and-duration-of-red-cell-transfusion-too-strict
#13
MULTICENTER STUDY
K Foley, D Poles, H Mistry, A Gray, P H B Bolton-Maggs
OBJECTIVES: To discover if any adverse clinical effects have been reported to the UK haemovigilance scheme, Serious Hazards of Transfusion (SHOT) relating to delays in set up of transfusion or extended transfusion time for red cell units. BACKGROUND: Current guidance for duration of transfusion is based on outdated studies that do not reflect current UK Blood Service practices. Recent evidence suggests that the '30-min rule' could be extended without adverse effects...
June 2016: Transfusion Medicine
https://www.readbyqxmd.com/read/27011677/nucleic-acid-testing-is-it-the-only-answer-for-safe-blood-in-india
#14
N K Naidu, Z S Bharucha, Vandana Sonawane, Imran Ahmed
BACKGROUND: With the implementation of NAT in countries around the world, there is a growing pressure on the transfusion services in India to adopt NAT testing. India has about 2545 licensed Blood Centres. The Transfusion Services in India are fragmented, poorly regulated and the quality standards are poorly implemented. Blood Centres are still dependent on replacement/family donors and in most places laboratory testing for Transfusion transmitted infections is not quality assured, laboratory equipment are not calibrated and maintained, and validation of results is not carried out...
January 2016: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/27005871/overnight-transfusions-in-new-zealand-hospitals-potential-risk-to-patients
#15
Rachel Donegan, Angela Wright, Louise Bobbitt, Richard Charlewood, Hilary Blacklock
AIMS: This audit aimed to assess how frequently overnight transfusions were taking place and compare it to the previous 2004 audit. METHOD: All red cell units transfused between 20:00 and 08:00 hours in low acuity areas over 4 weeks in 2010 in 8 of New Zealand's largest public hospitals were identified prospectively, followed by review of clinical notes and laboratory results by the hospital Transfusion Nurse Specialist (TNS). RESULTS: 535 red cell units were transfused overnight, or 9% of the total units administered over the study period...
March 11, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/26778838/knowledge-attitudes-and-clinical-practice-of-blood-products-prescribers-in-niamey
#16
Z Mayaki, R Kabo, M Moutschen, A Albert, N Dardenne, D Sondag, C Gérard
AIM OF THE STUDY: The lack of traceability and monitoring of blood donors and transfused patients constitute a barrier to the most basic rules of haemovigilance and overall good transfusion practices. This study draws up an inventory of knowledge, attitudes and clinical practice of blood prescribers in Niamey. MATERIALS AND METHODS: A questionnaire was administered to 180 prescribers of blood products in Niamey in 2011. Questions were related to basic informations on blood transfusion and clinical use of blood...
May 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/26689441/haemovigilance-of-reactions-associated-with-red-blood-cell-transfusion-comparison-across-17-countries
#17
M A M Rogers, J M Rohde, N Blumberg
BACKGROUND AND OBJECTIVES: The recent establishment of the National Healthcare Safety Network Hemovigilance Module in the United States affords an opportunity to compare results with those of other developed nations. MATERIALS AND METHODS: Using data from national haemovigilance systems, reactions associated with red blood cell (RBC) transfusion and residual risks of transfusion-transmitted infectious diseases were assembled from 17 nations. Country-specific rates of adverse events were pooled using random-effects Poisson regression...
April 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/26674828/improving-platelet-transfusion-safety-biomedical-and-technical-considerations
#18
REVIEW
Olivier Garraud, Fabrice Cognasse, Jean-Daniel Tissot, Patricia Chavarin, Syria Laperche, Pascal Morel, Jean-Jacques Lefrère, Bruno Pozzetto, Miguel Lozano, Neil Blumberg, Jean-Claude Osselaer
Platelet concentrates account for near 10% of all labile blood components but are responsible for more than 25% of the reported adverse events. Besides factors related to patients themselves, who may be particularly at risk of side effects because of their underlying illness, there are aspects of platelet collection and storage that predispose to adverse events. Platelets for transfusion are strongly activated by collection through disposal equipment, which can stress the cells, and by preservation at 22 °C with rotation or rocking, which likewise leads to platelet activation, perhaps more so than storage at 4 °C...
March 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/26596959/an-overview-of-the-role-of-microparticles-microvesicles-in-blood-components-are-they-clinically-beneficial-or-harmful
#19
REVIEW
Thierry Burnouf, Ming-Li Chou, Hadi Goubran, Fabrice Cognasse, Olivier Garraud, Jerard Seghatchian
Blood cells and tissues generate heterogeneous populations of cell-derived vesicles, ranging from approximately 50 nm to 1 µm in diameter. Under normal physiological conditions and as an essential part of an energy-dependent natural process, microparticles (MPs) are continuously shed into the circulation from membranes of all viable cells such as megakaryocytes, platelets, red blood cells, white blood cells and endothelial cells. MP shedding can also be triggered by pathological activation of inflammatory processes and activation of coagulation or complement systems, or even by shear stress in the circulation...
October 2015: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/26557816/evaluation-of-risk-minimisation-measures-for-blood-components-based-on-reporting-rates-of-transfusion-transmitted-reactions-1997-2013
#20
Markus B Funk, Margarethe Heiden, Peter Volkers, Annette Lohmann, Brigitte Keller-Stanislawski
BACKGROUND: To assess the impact of safety measures, we compared reporting rates of transfusion-related reactions before and after the implementation of six measures in 1999, 2004, 2006, 2008 and 2009. METHODS: Reporting rates of transfusion-transmitted bacterial infection (TTBI), viral infection (TTVI) and immune-mediated transfusion-related acute lung injury (TRALI) were calculated on the basis of confirmed annual reports and distributed blood components. RESULTS: The introduction of HCV NAT testing caused a significant reduction of HCV reporting rate from 1:0...
July 2015: Transfusion Medicine and Hemotherapy
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