keyword
MENU ▼
Read by QxMD icon Read
search

freckle

keyword
https://www.readbyqxmd.com/read/29091873/autophagy-participates-in-isoliquiritigenin-induced-melanin-degradation-in-human-epidermal-keratinocytes-through-pi3k-akt-mtor-signaling
#1
Zhibo Yang, Biyun Zeng, Yi Pan, Pan Huang, Chang Wang
Melanin is the pigment responsible for the color of human skin and hair. Melanin serves as a double-edge sword which can exert both protective and spot-causing effects on skin. Although melanin has an important role in protecting the skin against UV damage, an excessive or uneven melanin production can lead to the formation of freckles and age spots. Isoliquiritigenin (ISL) has been reported to inhibit melanin synthesis; however, its role in melanin degradation remains unclear. In the present study, we evaluated the detailed function of ISL in melanin degradation in human epidermal keratinocytes...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29057502/validation-of-digital-photographic-reference-scales-for-evaluating-facial-aging-signs
#2
Randa Jdid, Julie Latreille, Frédérique Soppelsa, Erwin Tschachler, Frédérique Morizot
BACKGROUND: Validated tools are essential to evaluate facial skin aging for both dermatological and cosmetic investigations. While many visual aging scales have been developed, few have been validated and none in terms of degree of distinguishability (DD). We developed and validated a series of visual scales using a novel digital interface for scoring facial skin aging in Caucasian women. MATERIALS AND METHODS: Three dermatologists independently established scales for 12 distinct aging signs from high-definition facial photographs of 400 adult women (Fitzpatrick phototypes I-IV) taken under standardized conditions...
October 22, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28979660/treatment-of-freckles-using-a-fractional-nonablative-2940nm-erb-yag-laser-in-a-series-of-asian-patients
#3
Brian Tian
OBJECTIVE: The purpose of this study was to demonstrate a novel, effective, and safe way to utilize the Erb:YAG laser to clear freckles in Type III/IV Asian skin. DESIGN: This was a prospective study. SETTING: The setting was a Singapore-based clinic. PARTICIPANTS: Participants included five women, aged 25 to 38 years, three with Skin Type III and two with Skin Type IV. All of them had freckles. MEASUREMENTS: Photographs were taken pretreatment and one month after laser treatment. Three independent physicians evaluated the photographs using a grading system...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28979012/focal-dermal-hypoplasia-goltz-syndrome-a-cross-sectional-study-from-eastern-india
#4
Sudip Kumar Ghosh, Abhijit Dutta, Sharmila Sarkar, Shanka Subhra Nag, Surajit Kumar Biswas, Prabhakar Mandal
INTRODUCTION: Focal dermal hypoplasia (Goltz syndrome), is an extremely rare genetic disorder characterized by distinct skin manifestations and a wide range of abnormalities involving the ocular, dental, skeletal, urinary, gastrointestinal, cardiovascular, and central nervous systems. The objective of the present series is to emphasize the different typical as well as unusual features of this rare syndrome. METHOLOGY: This cross-sectional observational study was performed over a period of 8 years in a tertiary care hospital of Eastern India...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28954101/molecular-basis-of-basal-cell-carcinoma
#5
REVIEW
Erik Montagna, Otávio Sérgio Lopes
Basal cell carcinoma is the most common cancer, presenting low mortality but high morbidity, and it has as risk factor exposure to sunlight, especially UVB spectrum. The most important constitutional risk factors for basal cell carcinoma development are clear phototypes (I and II, Fitzpatrick classification), family history of basal cell carcinoma (30-60%), freckles in childhood, eyes and light hair. The environmental risk factor better established is exposure to ultraviolet radiation. However, different solar exposure scenarios probably are independent risk factors for certain clinical and histological types, topographies and prognosis of this tumor, and focus of controversy among researchers...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28950052/melanocortin-1-receptor-mc1r-polymorphisms-influence-on-size-and-dermoscopic-features-of-nevi
#6
María Gabriela Vallone, Gemma Tell-Marti, Miriam Potrony, Aida Rebollo-Morell, Celia Badenas, Joan Anton Puig-Butille, Pol Gimenez-Xavier, Cristina Carrera, Josep Malvehy, Susana Puig
The melanocortin 1 receptor (MC1R) is a highly polymorphic gene. The loss-of-function MC1R variants ("R") have been strongly associated with red hair color phenotype and an increased melanoma risk. We sequenced the MC1R gene in 175 healthy individuals to assess the influence of MC1R on nevus phenotype. We identified that MC1R variant carriers had larger nevi both on the back [p-value = .016, adjusted for multiple parameters (adj. p-value)] and on the upper limbs (adj. p-value = .007). Specifically, we identified a positive association between the "R" MC1R variants and visible vessels in nevi [p-value = ...
September 26, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28915292/news-views-and-reviews-a-tool-for-my-laser-practice-i-simply-can-t-do-without-shining-a-light-on-my-favorite-light-source
#7
Eric F Bernstein
With laser surgery, what you see is what you get. Visualizing the target for treatment, be it a port-wine stain, a cluster of spider veins, a tattoo or freckles, or simply photodamaged skin requires seeing through surface reflections, dry skin, and often quite dark laser goggles. The tool that has been indispensable to me in my practice is the Syris v900L polarizing and magnifying headlamp. This indispensable tool makes laser treatment more precise, effective, and easier by truly shining a light on the subject of a laser treatment...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28911859/recent-development-of-signaling-pathways-inhibitors-of-melanogenesis
#8
REVIEW
Thanigaimalai Pillaiyar, Manoj Manickam, Sang-Hun Jung
Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation...
December 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28880216/inhibition-of-nat10-suppresses-melanogenesis-and-melanoma-growth-by-attenuating-microphthalmia-associated-transcription-factor-mitf-expression
#9
Taek-In Oh, Yoon-Mi Lee, Beong-Ou Lim, Ji-Hong Lim
N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable. Using a small molecule or small interfering RNA targeting NAT10, we examined the effect of NAT10 inhibition on melanogenesis and melanoma growth in human and mouse melanoma cells. Genetic silencing or chemical inhibition of NAT10 resulted in diminished melanin synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells...
September 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28872626/anti-melanogenic-effects-of-flavonoid-glycosides-from-limonium-tetragonum-thunb-bullock-via-inhibition-of-tyrosinase-and-tyrosinase-related-proteins
#10
Seul-Gi Lee, Fatih Karadeniz, Youngwan Seo, Chang-Suk Kong
Overproduction and stimulation of tyrosinase result in increased melanogenesis of which several skin disorders such as freckles, spots, and hyperpigmentation appear as complications. Limonium tetragonum is a halophyte well-known for its antioxidative properties. This study investigated the anti-melanogenic effects of solvent-partitioned L. tetragonum extracts (LTEs) and its bioactive constituents, two isolated flavonoid glycosides. Current study followed a set of experiments on B16-F10 mouse melanoma cell model with a focus on tyrosinase activity and production...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28842324/associations-of-mc1r-genotype-and-patient-phenotypes-with-braf-and-nras-mutations-in-melanoma
#11
Nancy E Thomas, Sharon N Edmiston, Peter A Kanetsky, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Anne E Cust, Hoda Anton-Culver, Stephen B Gruber, Li Luo, Irene Orlow, Anne S Reiner, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Eloise A Parrish, Honglin Hao, David C Gibbs, Jill S Frank, David W Ollila, Colin B Begg, Marianne Berwick, Kathleen Conway
Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies. We sought to determine for 1,227 participants in the international population-based Genes, Environment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF(+) were associated with younger age, blond/light brown hair, increased nevi, and less freckling, and NRAS(+) with older age relative to the wild type (BRAF(-)/NRAS(-)) melanomas (all P < 0...
August 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28833649/adar1-splicing-mutation-leading-to-dyschromatosis-hereditaria-in-a-caucasian-patient
#12
J Petre, E Lasseaux, C Ged, B Arveiler, A Taïeb, F Morice-Picard
Dyschromatosis symmetrica hereditaria (DSH, OMIM 127400) is a rare autosomal dominant disorder characterized by hypo-and hyperpigmented macules on the dorsal aspects of hands and feet and freckle-like macules on the face(1). Histologically, there is an increase in epidermal melanin pigment in the hyperpigmented area and with normally structured melanosomes, together with an absence of melanin pigment in hypopigmented macules. The disease is known to be caused by mutations in the adenosine deaminase, RNA-specific (ADAR) gene (Miyamura et al...
August 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28776093/identification-of-an-atypical-microdeletion-generating-the-rnf135-suz12-chimeric-gene-and-causing-a-position-effect-in-an-nf1-patient-with-overgrowth
#13
Luca Ferrari, Giulietta Scuvera, Arianna Tucci, Donatella Bianchessi, Francesco Rusconi, Francesca Menni, Elena Battaglioli, Donatella Milani, Paola Riva
Neurofibromatosis type I (NF1) microdeletion syndrome, which is present in 4-11% of NF1 patients, is associated with a severe phenotype as it is caused by the deletion of NF1 and other genes in the 17q11.2 region. The variable expressivity of the disease makes it challenging to establish genotype-phenotype correlations, which also affects prognosis and counselling. We here describe a 3-year-old NF1 patient with an atypical deletion and a complex phenotype. The patient showed overgrowth, café au lait spots, inguinal freckling, and neurological abnormalities...
October 2017: Human Genetics
https://www.readbyqxmd.com/read/28774050/freckle-defect-formation-near-the-casting-interfaces-of-directionally-solidified-superalloys
#14
Jianping Hong, Dexin Ma, Jun Wang, Fu Wang, Baode Sun, Anping Dong, Fei Li, Andreas Bührig-Polaczek
Freckle defects usually appear on the surface of castings and industrial ingots during the directional solidification process and most of them are located near the interface between the shell mold and superalloys. Ceramic cores create more interfaces in the directionally solidified (DS) and single crystal (SX) hollow turbine blades. In order to investigate the location of freckle occurrence in superalloys, superalloy CM247 LC was directionally solidified in an industrial-sized Bridgman furnace. Instead of ceramic cores, Alumina tubes were used inside of the casting specimens...
November 16, 2016: Materials
https://www.readbyqxmd.com/read/28747691/the-absence-that-makes-the-difference-choroidal-abnormalities-in-legius-syndrome
#15
Arianna Tucci, Veronica Saletti, Francesca Menni, Claudia Cesaretti, Giulietta Scuvera, Silvia Esposito, Giulia Melloni, Susanna Esposito, Donatella Milani, Cristina Cereda, Mario Cigada, Laura Tresoldi, Francesco Viola, Federica Natacci
Neurofibromatosis type 1 (NF1) is an hereditary disorder characterized by abnormal proliferation of multiple tissues of neural crest origin, and presents mainly with multiple café-au-lait macules, axillary freckling and neurofibromas. Choroidal involvement in NF1 patients has been studied, thanks to the development of non-invasive tools such as infrared monochromatic light during fundus examination, which showed bright patchy lesions consistent with choroidal nodules. Choroidal abnormalities identified with near-infrared reflectance have reported with a frequency of up to 100% in NF1, and have been recently been proposed as a novel diagnostic criterion for NF1...
July 27, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28746718/association-of-incident-amelanotic-melanoma-with-phenotypic-characteristics-mc1r-status-and-prior-amelanotic-melanoma
#16
Steven Vernali, Weston T Waxweiler, Patrick M Dillon, Peter A Kanetsky, Irene Orlow, Li Luo, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Anne E Cust, David W Ollila, Colin B Begg, Marianne Berwick, Nancy E Thomas
Importance: We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown. Objective: To determine whether phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are associated with histopathologically amelanotic melanoma...
October 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28717080/addison-s-disease-caused-by-tuberculosis-with-atypical-hyperpigmentation-and-active-pulmonary-tuberculosis
#17
Hiroki Namikawa, Yasuhiko Takemoto, Shigeto Kainuma, Sakurako Umeda, Ayako Makuuchi, Kazuo Fukumoto, Masanori Kobayashi, Shigeki Kinuhata, Yoshihiro Isaka, Hiromitsu Toyoda, Noriko Kamata, Yoshihiro Tochino, Yoshikazu Hiura, Mina Morimura, Taichi Shuto
We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and the occurrence of new freckles, that was diagnosed in the presence of active pulmonary tuberculosis. The clinical condition of the patient was markedly ameliorated by the administration of hydrocortisone and anti-tuberculosis agents. When exacerbation of the pigmentation of the freckles and/or the occurrence of new freckles are noted, Addison's disease should be considered as part of the differential diagnosis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715582/iris-freckles-a-potential-biomarker-for-chronic-sun-damage
#18
Christoph Schwab, Christoph Mayer, Iris Zalaudek, Regina Riedl, Markus Richtig, Werner Wackernagel, Rainer Hofmann-Wellenhof, Georg Richtig, Gerald Langmann, Lisa Tarmann, Andreas Wedrich, Erika Richtig
Purpose: To investigate the role of sunlight exposure in iris freckles formation. Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Results: Six hundred thirty-two participants (n = 360; 57% female) were examined...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28714536/the-evaluation-of-acute-toxicity-antimicrobial-activity-of-1-phenyl-5-p-tolyl-1h-1-2-3-triazole-and-binding-to-human-serum-albumin
#19
Hong-Ye Duan, Jian-Ling Li, Lu-Yong Wu, Huo-Ming Shu, Yu-Xue Chen, Guo-Hua Ding, Run-Cong Dong, Hong-Zong Si, Xia Zhong, Wen-Ying He
1-Phenyl-5-p-tolyl-1H-1, 2, 3-triazole (PPTA) was a synthesized compound. The result of acute toxicities to mice of PPTA by intragastric administration indicated that PPTA did not produce any significant acute toxic effect on Kunming strain mice. It exhibited the various potent inhibitory activities against two kinds of bananas pathogenic bacteria, black sigatoka and freckle, when compared with that of control drugs and the inhibitory rates were up to 64.14% and 43.46%, respectively, with the same concentration of 7...
July 17, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28697505/the-importance-of-11%C3%AE-oh-15-oxo-and-16-en-moieties-of-11%C3%AE-hydroxy-15-oxo-kaur-16-en-19-oic-acid-in-its-inhibitory-activity-on-melanogenesis
#20
Azusa Kuroi, Koji Sugimura, Ayako Kumagai, Arihiro Kohara, Yasuo Nagaoka, Hidehisa Kawahara, Minori Yamahara, Nobuo Kawahara, Hiroshi Takemori, Hiroyuki Fuchino
Cosmetic industries have an interest in exploring and developing materials that have the potential to regulate melanin synthesis in human skin. Although melanin protects the skin from ultraviolet irradiation, excess melanin can be undesirable, particularly on the face where spots or freckles are associated with an appearance of aging. In this study, we found that ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11α-OH KA) in Pteris dispar Kunze strongly inhibited melanin synthesis by suppressing tyrosinase gene expression...
2017: Skin Pharmacology and Physiology
keyword
keyword
89754
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"