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https://www.readbyqxmd.com/read/29793176/non-ldl-dyslipidemia-is-prevalent-in-the-young-and-determined-by-lifestyle-factors-and-age-the-lifelines-cohort
#1
Jeroen K de Vries, Jan W Balder, Michelle J Pena, Petra Denig, Andries J Smit
BACKGROUND AND AIMS: Non-LDL dyslipidemia (NLD) confers cardiovascular risk, and prevalence rates appear to be high in elderly populations. Small cohorts have identified several lifestyle, anthropometric, and medical factors associated with NLD. We aimed to assess sex- and age-specific prevalence of NLD in a contemporary population cohort (n = 167 729), and to identify independent determinants of NLD, focusing on lifestyle, anthropometric, and medical factors. METHODS: The prevalence of NLD was assessed per 10-year age intervals in adults without cardiovascular disease not using lipid-modifying drugs from the Dutch LifeLines cohort...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29793080/visualizing-the-shape-of-society-an-analysis-of-public-bads-and-burden-allocation-due-to-household-consumption-using-an-input-output-approach
#2
Andrew Chapman, Yosuke Shigetomi
This study investigates how our lifestyles can cause societal issue including a reduction in social equity due to the consumption of natural resources. Based on a range of household environmental footprints and their application to a quantitative social equity evaluation framework, a methodology is proposed which identifies the creation and origin of public bads within society. This research builds on the methodologies of energy policy sustainability evaluation incorporated with environmentally extended input output analysis in order to critically assess lifestyle-based consumption impacts, and to quantify the allocation of subsequent burdens across generations...
May 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29792540/cerebral-amyloid-angiopathy-diagnosis-and-potential-therapies
#3
Stewart A Weber, Ranish K Patel, Helmi L Lutsep
Cerebral amyloid angiopathy (CAA) is characterized by the pathologic deposition of amyloid-beta within cortical and leptomeningeal arteries, arterioles, capillaries and, in rare cases, the venules of the brain. It is often associated with the development of lobar intracerebral hemorrhages but may cause other neurologic symptoms or be asymptomatic. Magnetic resonance imaging characteristics, such as lobar microbleeds, support a diagnosis of CAA and assist with hemorrhage risk assessments. Immunosuppressants are used to treat rarer inflammatory forms of CAA...
May 24, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29792364/current-evidence-in-the-stability-of-medicines-in-dose-administration-aids-implications-for-patient-safety
#4
Estela R García, Stefanie Thalhauser, Hèctor R Loscertales, Pilar Modamio, Cecilia F Lastra, Eduardo L Mariño
As the elderly population and polypharmacy are increasing, it is predicted that interventions to enhance medication adherence, as dose administration aids (DAA), will grow too. One of the limitations of repackaging medicines into DAA is to assure the stability of medicines, and, therefore, their quality, efficacy and safety. Area covered: This article collects and summarises data of all the stability studies of repackaged medicines into DAAs, as the result of a computerized search in databases (PubMed, Google Scholar, SciELO, and reference texts related to the field...
May 24, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29791631/educational-technology-a-facilitating-instrument-for-the-elderly-care
#5
Rachel da Silva Serejo Cardoso, Selma Petra Chaves Sá, Ana Maria Domingos, Vera Maria Sabóia, Tauan Nunes Maia, Joviria Marcia Ferreira de Oliveira Padilha, Glycia de Almeida Nogueira
OBJECTIVE: To develop educational technology with caregivers of older people based on the needs, difficulties and concerns related to the elderly care expressed by the caregivers themselves. METHOD: Research of qualitative nature, with participant observation, based on concepts used by Paulo Freire. Data collection and analysis used the "World Cafe" methodology and the thematic content analysis, respectively. RESULT: The needs of these caregivers refer to their training and information on aging...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791627/emergency-care-units-and-dimensions-of-accessibility-to-health-care-for-the-elderly
#6
Giovana Aparecida de Souza Scolari, Leidyani Karina Rissardo, Vanessa Denardi Antoniassi Baldissera, Lígia Carreira
OBJECTIVE: to understand the conception of the elderly and their caregivers about the accessibility to health mediated by the service in Emergency Care Units. Methodo: a qualitative study conducted with 25 elderly patients and caregivers at Emergency Care Units in a city of Paraná, using Grounded Theory as a methodological reference. RESULTS: According to the participants, the resources available in these services guarantee medical consultation and provide access to exams and medicines...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791197/gender-differences-in-psychosocial-determinants-of-self-perceived-health-among-portuguese-older-adults-in-nursing-homes
#7
Violeta Alarcão, Teresa Madeira, Catarina Peixoto-Plácido, Nuno Sousa-Santos, Elisabete Fernandes, Paulo Nicola, Osvaldo Santos, João Gorjão-Clara
OBJECTIVES: Self-perceived health declines with age, varies by gender and is a predictor of mortality, morbidity, physical and psychological functioning. However, gender differences in health and illness perception are complex and not yet fully understood. This study aimed to explore gender-related differences in psychosocial determinants of self-perceived health among older adults living in nursing homes. METHOD: Nationwide face-to-face survey of the Portuguese population aged 65 and over...
May 23, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29790981/economic-impact-of-aging-on-the-initial-spine-care-of-patients-with-acute-spine-trauma-from-bedside-to-teller
#8
Julio C Furlan, Michael G Fehlings, B Catharine Craven
BACKGROUND: Aging of the population has prompted an escalation of service utilization and costs in many jurisdictions including North America. However, relatively little is known on the economic impact of old age on the management of acute spine trauma (AST). OBJECTIVE: To examine the potential effects of age on the service utilization and costs of the management of patients with acute spine trauma. METHODS: This retrospective cohort study included consecutive patients with AST admitted to an acute spine care unit of a Canadian quaternary university hospital between February, 2002 and September, 2007...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29790199/relationship-between-cumulative-ultraviolet-exposure-and-cognitive-function-in-a-rural-elderly-chinese-population
#9
Shimeng Xin, Dechun Luan, Xue Wang, Fang Wang, Yang Liu, Qian Gao
OBJECTIVES: Some researchers have focused on the relationship between vitamin D and cognition, but the conclusions are inconsistent. We estimated cumulative UV exposure could be used to represent the individual's long-term vitamin D status and investigated its association with global cognitive function in elderly Chinese. METHODS: A total of 641 participants aged 60 years and over were recruited in a rural area of Shenyang, China. All were interviewed to obtain data regarding sociodemographic characteristics and time spent outdoors...
May 22, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29789783/mir-142-5p-in-bone-marrow-derived-mesenchymal-stem-cells-promotes-osteoporosis-involving-targeting-adhesion-molecule-vcam-1-and-inhibiting-cell-migration
#10
Zhaowei Teng, Xueguan Xie, Yun Zhu, Jianping Liu, Xingbo Hu, Qiang Na, Xiongwen Zhang, Guojun Wei, Shen Xu, Yugang Liu, Xiguang Zhang, Cory J Xian
Osteoporosis is a systemic bone metabolic disease that is highly prevalent in the elderly population, particularly in postmenopausal women, which results in enhanced bone fragility and an increased susceptibility to fractures. However, the underlying molecular pathogenesis mechanisms still remain to be further elucidated. In this study, in a rat ovariectomy- (OVX-) induced postmenopausal osteoporosis model, aberrant expression of a microRNA miR-142-5p and vascular cell adhesion molecule 1 (VCAM-1) was found by RNA sequencing analysis and qRT-PCR...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789530/efficient-blood-brain-barrier-opening-in-primates-with-neuronavigation-guided-ultrasound-and-real-time-acoustic-mapping
#11
Shih-Ying Wu, Christian Aurup, Carlos Sierra Sanchez, Julien Grondin, Wenlan Zheng, Hermes Kamimura, Vincent P Ferrera, Elisa E Konofagou
Brain diseases including neurological disorders and tumors remain under treated due to the challenge to access the brain, and blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits the development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is the sole method to open the BBB noninvasively, locally, and transiently and facilitate drug delivery, while translation to the clinic is challenging due to long procedure, targeting limitations, or invasiveness of current systems...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789466/association-of-tea-consumption-with-risk-of-alzheimer-s-disease-and-anti-beta-amyloid-effects-of-tea
#12
REVIEW
Curt Anthony Polito, Zhuo-Yu Cai, Yun-Long Shi, Xu-Min Li, Rui Yang, Meng Shi, Qing-Sheng Li, Shi-Cheng Ma, Li-Ping Xiang, Kai-Rong Wang, Jian-Hui Ye, Jian-Liang Lu, Xin-Qiang Zheng, Yue-Rong Liang
Neurodegenerative disease Alzheimer's disease (AD) is attracting growing concern because of an increasing patient population among the elderly. Tea consumption is considered a natural complementary therapy for neurodegenerative diseases. In this paper, epidemiological studies on the association between tea consumption and the reduced risk of AD are reviewed and the anti-amyloid effects of related bioactivities in tea are summarized. Future challenges regarding the role of tea in preventing AD are also discussed...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29789047/concerns-for-bleeding-in-the-elderly-with-the-use-of-direct-oral-anticoagulants
#13
Michelle Min, Stephanie Sibicky
Since Food and Drug Administration approval of dabigatran in 2010, direct oral anticoagulants (DOACs) have been alternatives to warfarin for patients who are at risk for cardioembolic complications of nonvalvular atrial fibrillation. Unfortunately, there are limited safety data available on the use of these newer agents in older adults, particularly risks of gastrointestinal, intracranial, and major bleeding (as defined by the International Society on Thrombosis and Haemostasis) in those 75 years of age and older...
May 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29789046/management-of-venous-thromboembolism-in-the-elderly-a-review-of-the-non-vitamin-k-oral-anticoagulants
#14
Laressa Bethishou, Tania Gregorian, Kimberly Won, Kristina Lopez, Laura V Tsu
Objective To provide an up-to-date review of the available evidence regarding pharmacotherapeutic management of venous thromboembolic events in the geriatric population. Data Sources A PubMed search of articles published through August 2017 was performed using a combination of the following words: apixaban, betrixaban, dabigatran, edoxaban, enoxaparin, geriatric, heparin, idaricizumab, rivaroxaban, and venous thromboembolism. Study Selection/data Extraction Relevant original research, review articles, and guidelines were assessed for the management of elderly patients with venous thromboembolism (VTE)...
May 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29788943/profiling-non-tuberculous-mycobacteria-in-an-asian-setting-characteristics-and-clinical-outcomes-of-hospitalized-patients-in-singapore
#15
Albert Y H Lim, Sanjay H Chotirmall, Eric T K Fok, Akash Verma, Partha P De, Soon Keng Goh, Ser Hon Puah, Daryl E L Goh, John A Abisheganaden
BACKGROUND: Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of inpatients in whom NTM was isolated from various anatomical sites in a Singaporean population attending a major tertiary referral centre. METHODS: Demographic profile, clinical data, and characteristics of patients hospitalized with NTM isolates at a major tertiary hospital over two-year period were prospectively assessed (2011-2012)...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788464/confucian-values-as-a-buffer-against-age-based-stereotype-threat-for-chinese-older-adults
#16
Shyuan Ching Tan, Sarah J Barber
Objectives: Research has shown that stereotype threat can impair older adults' memory in Western cultures. We tested whether this also occurs for older adults from the East Asian Chinese culture. We also tested whether an intervention that highlighted Confucian principles would protect Chinese older adults from stereotype threat's detrimental effects. Method : Culturally-Chinese older adults residing in the United States completed a memory test either under age-based stereotype threat about cognitive decline or not...
May 16, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29788356/return-to-duty-rates-following-minimally-invasive-spine-surgery-performed-on-active-duty-military-patients-in-an-ambulatory-surgery-center
#17
Elder Granger, Stefan Prada, Zoltan Bereczki, Michael Weiss, Chip Wade, Reginald Davis
Background: Low back pain is a primary health care utilization driver in the US population. Health care evaluation visits for low back pain are as common as medical evaluation for the common cold. Low back pain is the most common reason for reductions in activities of daily living and work activity in the general population. Although these statistics are compelling, in the military population, there is arguably a significantly greater economic impact on the military population, as the cost to train, retain, and deploy a service member is a tremendous cost...
May 21, 2018: Military Medicine
https://www.readbyqxmd.com/read/29788352/revisiting-the-low-birthweight-paradox-using-sibling-data-with-implications-for-the-classification-of-low-birthweight
#18
M Tabet, L H Flick, H Xian, J J Chang
Background: We examined the birthweight threshold for increased odds of neonatal death among second births based on their elder sibling's birthweight category. Methods: This population-based cohort study included 190 575 women who delivered their first two non-anomalous singleton live births in Missouri (1989-2005). We examined the birthweight distribution and neonatal mortality curves of second births whose elder sibling had low versus adequate/high birthweight...
May 19, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29786824/intramedullary-nail-with-integrated-cephalocervical-screws-in-the-intertrochanteric-fractures-treatment-position-of-screws-in-fracture-stability
#19
Gökhan Kaynak, Mehmet Can Ünlü, Mehmet Fatih Güven, Ozan Ali Erdal, Okan Tok, Hüseyin Botanlıoğlu, Önder Aydıngöz
BACKGROUND: Stable fracture fixation is important in the treatment of intertrochanteric femur (ITF) fractures in the elderly population to prevent the loss of reduction, achieve early mobility, and restore independence. The aim of this study was to present the results of surgical treatment of stable and unstable ITF fractures using a trochanteric antegrade intramedullary nail with two cephalocervical screws in an integrated mechanism (Intertan®; Smith & Nephew, Memphis, TN) and evaluate the relationship between the loss of reduction and screw position in the femoral neck in two planes...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786817/targeted-cardiopulmonary-resuscitation-training-focused-on-the-family-members-of-high-risk-patients-at-a-regional-medical-center-a-comparison-between-family-members-of-high-risk-and-no-risk-patients
#20
Kap Su Han, Ji Sung Lee, Su Jin Kim, Sung Woo Lee
BACKGROUND: We developed a hospital-based cardiopulmonary resuscitation (CPR) training model focused on the target population (family members of patients with potential risks for cardiac arrest) and compared the outcome of CPR training between target and non-target populations for validity. METHODS: Family members of patients in training were divided into three groups on the basis of patients' diseases, as follows: 1) the cardio-specific (CS) risk group, including family members of patients with cardiac disease at risk of cardiac arrest; 2) the cardiovascular (CV) risk group, including family members of patients with risk factors for cardiovascular disease; and 3) the no-risk group...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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