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https://www.readbyqxmd.com/read/28097633/meropenem-dosing-based-on-a-population-pharmacokinetic-pharmacodynamic-model-in-elderly-patients-with-infection-of-the-lower-respiratory-tract
#1
Qing-Tao Zhou, Bei He, Ning Shen, Ying Liang, Li-Na Sun
BACKGROUND: Meropenem is used for the treatment of severe lower respiratory tract infections (LRTIs) caused by multidrug-resistant Gram-negative bacilli. OBJECTIVE: We evaluated the clinical benefits of a strategy of meropenem dosing based on a population pharmacokinetics/pharmacodynamics (PK/PD) model in elderly patients with an LRTI. METHODS: In this prospective single-center open-label randomized controlled trial, 79 elderly patients with an LRTI caused by Gram-negative bacilli were randomized to a study group (SG) or a control group (CG)...
January 17, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28097450/contemporary-thoughts-on-the-management-of-spigelian-hernia
#2
V Webber, C Low, R J E Skipworth, S Kumar, A C de Beaux, B Tulloh
BACKGROUND: Spigelian hernias are said to be a rare condition of the elderly population, usually arising below the arcuate line. Local experience has led us to challenge these commonly held beliefs. METHODS: Operations for Spigelian hernia from 2006-2016 were identified from the Edinburgh Lothian Surgical Audit computerised database and case notes were reviewed. RESULTS: One hundred and one patients underwent surgery for 107 Spigelian hernias in the 10-year period...
January 17, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28096999/decreasing-skeletal-muscle-as-a-risk-factor-for-mortality-in-elderly-patients-with-sepsis-a-retrospective-cohort-study
#3
Keita Shibahashi, Kazuhiro Sugiyama, Masahiro Kashiura, Yuichi Hamabe
BACKGROUND: Older patients account for the majority of patients with sepsis. The objective of this study was to determine if decreased skeletal muscle mass is associated with outcomes in elderly patients with sepsis. METHODS: Patients (60 years and older) who were admitted to a tertiary medical center intensive care unit with a primary diagnosis of sepsis between January 2012 and February 2016 were included. Patients who had not undergone abdominal computed tomography on the day of admission, had cardiopulmonary arrest on arrival, or had iliopsoas abscess were excluded from the analyses...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28096126/the-age-related-eye-disease-2-study-micronutrients-in-the-treatment-of-macular-degeneration
#4
REVIEW
Aruna Gorusupudi, Kelly Nelson, Paul S Bernstein
Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. With an increasingly aged population worldwide, the need for the prevention of AMD is rising. Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress-related retinal damage as an important contributing factor. In general, diet is an excellent source of the antioxidants, vitamins, and minerals necessary for healthy living; moreover, the general public is often receptive to recommendations made by physicians and health care workers regarding diet and supplements as a means of empowering themselves to avoid common and worrisome ailments such as AMD, which has made epidemiologists and clinicians enthusiastic about dietary intervention studies...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28096026/clinical-validation-of-the-nursing-outcome-falls-prevention-behavior-in-people-with-stroke
#5
Alice G de Sousa Costa, Thelma Leite de Araujo, Tahissa Frota Cavalcante, Marcos V Oliveira Lopes, Ana R de Souza Oliveira-Kumakura, Francisca B Chaves Costa
PURPOSE: To review the nursing outcome, Fall Prevention Behavior, and clinically validate its indicators in people with stroke. METHODS: A methodological study performed with 106 patients in two outpatient clinics, from July to September of 2013. Two pairs of trained nurses applied the NOC scale, one with and one without the use of operational definitions. The internal consistency, stability and difference between the medians obtained by nurses were compared within and between pairs...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28095780/effectiveness-of-medication-review-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
Victor Johan Bernard Huiskes, David Marinus Burger, Cornelia Helena Maria van den Ende, Bartholomeus Johannes Fredericus van den Bemt
BACKGROUND: Medication review is often recommended to optimize medication use. In clinical practice it is mostly operationalized as an intervention without co-interventions during a short term intervention period. However, most systematic reviews also included co-interventions and prolonged medication optimization interventions. Furthermore, most systematic reviews focused on specific patient groups (e.g. polypharmacy, elderly, hospitalized) and/or on specific outcome measures (e.g. hospital admissions and mortality)...
January 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28095520/dental-implants-in-the-elderly-population-a-long-term-follow-up
#7
Sharon M Compton, Danielle Clark, Stephanie Chan, Iris Kuc, Berhanu A Wubie, Liran Levin
PURPOSE: The objectives of this study were to evaluate implant survival and success in the elderly population and to assess indicators and risk factors for success or failure of dental implants in older adults (aged 60 years and older). MATERIALS AND METHODS: This historical prospective study was developed from a cohort of patients born prior to 1950 who received dental implants in a single private dental office. Implant survival and marginal bone levels were recorded and analyzed with regard to different patient- and implant-related factors...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28095397/a-randomised-phase-ii-trial-and-feasibility-study-of-palliative-chemotherapy-in-frail-or-elderly-patients-with-advanced-gastroesophageal-cancer-321go
#8
P S Hall, S R Lord, M Collinson, H Marshall, M Jones, C Lowe, H Howard, D Swinson, G Velikova, A Anthoney, R Roy, J Dent, S Cheeseman, K Last, M T Seymour
BACKGROUND: Elderly patients are commonly under-represented in cancer clinical trials. The 321GO was undertaken in preparation for a definitive phase three trial assessing different chemotherapy regimens in a frail and/or elderly population with advanced gastroesophageal (GO) cancer. METHODS: Patients with advanced GO cancer considered unfit for conventional dose chemotherapy were randomly assigned in a 1 : 1 : 1 ratio to: epirubicin, oxaliplatin and capecitabine (EOX); oxaliplatin and capecitabine (OX); and capecitabine alone (X) (all 80% of full dose and unblinded)...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28095385/early-cholecystectomy-for-acute-cholecystitis-in-the-elderly-population-a-systematic-review-and-meta-analysis
#9
Charlotte S Loozen, Bert van Ramshorst, Hjalmar C van Santvoort, Djamila Boerma
BACKGROUND: In the era of advanced surgical techniques and improved perioperative care, the willingness to perform emergency operations in elderly patients continues to increase. This systematic review aimed at assessing the clinical outcomes of early cholecystectomy in elderly patients with acute cholecystitis. METHODS: Medline, Embase, and Cochrane Library databases were systematically searched for studies reporting on early cholecystectomy for acute cholecystitis in patients aged ≥70 years...
January 18, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28095033/detection-of-the-toughest-pedestrian-injury-risk-as-a-smooth-function-of-age
#10
Tobias Niebuhr, Mirko Junge
OBJECTIVE: While it is common to regard age-specific groups (e.g. children, adults, elderly), smooth trends conditional on the age are mainly ignored in the literature. The present study examines the pedestrian injury risk in full-frontal pedestrian to passenger car accidents and incorporates the age -besides the collision speed and the injury severity- as a plug-in parameter. METHODS: Recent work introduced a model for pedestrian injury risk functions using explicit formulae with easily interpretable model parameters...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28094857/use-of-oncept-melanoma-vaccine-in-69-canine-oral-malignant-melanomas-in-the-uk
#11
S Verganti, D Berlato, L Blackwood, I Amores-Fuster, G A Polton, R Elders, R Doyle, A Taylor, S Murphy
OBJECTIVES: Oral malignant melanomas carry a poor-to-guarded prognosis because of their local invasiveness and high metastatic propensity. The Oncept melanoma vaccine is licensed to treat dogs with stage II or III locally-controlled oral malignant melanoma and this retrospective study aimed to assess survival of affected dogs treated with the vaccine in the UK. MATERIAL AND METHODS: Medical records of dogs with histopathologically-confirmed oral malignant melanoma that received the vaccine as part of their treatment were evaluated...
January 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28094076/influenza-vaccination-in-older-people-with-diabetes-and-their-household-contacts
#12
Lin Yang, Hairong Nan, Jun Liang, Yin Hang Chan, Laam Chan, Rita Wing Man Sum, Yee Mei Kwan, Feifei Zhou, Huaiqing Meng, Lorna Kwai Ping Suen
BACKGROUND: People with diabetes are at a higher risk of influenza infections and severe complications. The vaccination of close contacts could offer indirect protection to people with diabetes; this is known as "herd immunity." The aim of this study is to investigate the vaccination rates of people with diabetes and their household contacts in Hong Kong. RESEARCH DESIGN AND METHODS: Face-to-face interviews with 158 patients diagnosed with Type 2 diabetes and aged ⩾65years were conducted in clinics...
January 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28093824/excess-mortality-after-hip-fracture-in-elderly-persons-from-europe-and-the-usa-the-chances-project
#13
M Katsoulis, V Benetou, T Karapetyan, D Feskanich, F Grodstein, U Pettersson-Kymmer, S Eriksson, T Wilsgaard, L Jørgensen, L A Ahmed, B Schöttker, H Brenner, A Bellavia, A Wolk, R Kubinova, B Stegeman, M Bobak, P Boffetta, A Trichopoulou
BACKGROUND: Hip fractures are associated with diminished quality of life and survival especially amongst the elderly. OBJECTIVE: All-cause mortality after hip fracture was investigated to assess its magnitude. METHODS: A total of 122 808 participants from eight cohorts in Europe and the USA were followed up for a mean of 12.6 years, accumulating 4273 incident hip fractures and 27 999 deaths. Incident hip fractures were assessed through telephone interviews/questionnaires or national inpatient/fracture registries, and causes of death were verified with death certificates...
January 17, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28093411/age-and-sex-related-influences-on-left-ventricular-mechanics-in-elderly-individuals-free-of-prevalent-heart-failure-the-aric-study-atherosclerosis-risk-in-communities
#14
Chung-Lieh Hung, Alexandra Gonçalves, Amil M Shah, Susan Cheng, Dalane Kitzman, Scott D Solomon
BACKGROUND: Advanced age is related to left ventricular (LV) remodeling. We sought to investigate the relationships between aging, elevated hemodynamic load, cardiac mechanics, and LV remodeling in an elderly community-based population. METHODS AND RESULTS: We studied 1105 subjects (76±5 years, 61% women) without prevalent heart failure, who attended the visit 5 of the ARIC study (Atherosclerosis Risk in Communities). LV global longitudinal strain, global circumferential strain, and torsion indices were analyzed using 3-dimensional echocardiography...
January 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28093252/low-energy-open-ankle-fractures-in-the-elderly-outcome-and-treatment-algorithm
#15
Asanka Wijendra, Rupali Alwe, Michael Lamyman, George A Grammatopoulos, Gregoris Kambouroglou
BACKGROUND: With an aging but still active population, open ankle fractures are increasingly presenting as low energy fragility injuries, sharing many characteristics with that of hip fractures. Yet, there is little in the literature on the management and outcome of these fractures. The primary aim of this study was to describe the outcome following open, ankle fragility fracture. Our secondary aim was to identify potential factors that improved outcome. METHODS: All consecutive, low energy open ankle fractures treated at a Level I Trauma Centre over a five-year period were included...
December 10, 2016: Injury
https://www.readbyqxmd.com/read/28092801/the-association-between-personal-income-and-aging-a-population-based-13-year-longitudinal-study
#16
Tzu-Yu Lin, Chia-Yu Chen, Chueh-Yung Tsao, Kuang-Hung Hsu
INTRODUCTION: Population aging is set to increase the elder dependency ratio, causing a rapid increase in healthcare expenditures and financial burden on the government. This study aims to construct an aging score from age-related diseases and to perform longitudinal analyses to examine the association between personal income and aging. METHODS: A total of 86,838 subjects drawn from a community with 384,617 residents in northern Taiwan were examined. Personal income and aging-related diseases were measured from the National Health Insurance database during 1997-2010...
January 9, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28092293/the-association-between-symptomatic-and-diagnostic-depression-and-pain-among-the-elderly-population-in-south-korea
#17
Wanhyung Lee, Kwanyoung Hong, Sung-Shil Lim, Dong Hyun Kim, Jin-Ha Yoon
The exact nature of pain (amount or severity) associated with in depression in the elderly population has not been studied extensively yet. We investigated the association between the characteristics of pain and both symptomatic and diagnostic depression using data from the 2012 Korean Longitudinal Study of Aging (2164 men, 2066 women). Symptomatic depression was identified a score of 12 or higher on the 10-item Center for Epidemiologic Studies-Depression Scale. Odds ratios with a 95% confidence interval was calculated for depression using multiple logistic regression models after adjusting for age, sex, socioeconomic status, health behavioral factors, and chronic diseases...
January 14, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28091833/the-gap-between-indicated-and-prescribed-stroke-prevention-therapies-in-a-high-risk-geriatric-population
#18
Mohammed Shurrab, Eugene Crystal, Denis O'Donnell, Hrishikesh Navare, Paula Neves, Rasha Khatib, Ilan Lashevsky, David Newman
PURPOSE: The use of oral anticoagulation (OAC) in the elderly population with atrial fibrillation (AF) treated in long-term care (LTC) facilities is inconsistent. We examined the magnitude and sources of the gap between indicated and prescribed OAC in the elderly population with AF. METHODS: We retrospectively scanned the electronic medical record (EMR) and pharmacy data of 25 LTC facilities in Ontario, Canada. The diagnosis of AF was drawn from EMR. Different attributable risk factors for possible failure to prescribe OAC were examined...
January 16, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28091352/elder-abuse-by-abandonment-in-india-a-novel-community-awareness-and-intervention-strategy
#19
Mangal S Kardile, Carmelle Peisah
India, along with the rest of the world, is aging rapidly, but more so. Of a total population of over 1.2 billion, the aging population over 60 years is 109 million, projected to rise above 300 million by the year 2050, exceeding the younger population. One important ramification of this highly populous and under-resourced setting is that it provides a ripe environment for elder abuse (Chokkanathan and Lee, 2005), a problem besetting vulnerable aging populations globally (Patterson and Ploeg, 2007).
January 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28090681/excess-of-exercise-increases-the-risk-of-atrial-fibrillation
#20
REVIEW
A Müssigbrodt, A Weber, J Mandrola, Y van Belle, S Richter, M Döring, A Arya, P Sommer, A Bollmann, G Hindricks
An interesting and still not well-understood example for old medical wisdom "Sola dosis facit venenum" is the increased prevalence of atrial fibrillation (AF) in athletes. Numerous studies have shown a fourfold to eightfold increased risk of AF in athletes compared to the normal population. Analysis of the existing data suggests a dose-dependent effect of exercise. Moderate exercise seems to have a protective effect and decreases the risk of AF, whereas excessive exercise seems to increase the risk of AF. The described cases illustrate clinical manifestations within the spectrum of AF in elderly athletes, that is, exercise-induced AF, vagal AF, chronic AF, and atrial flutter...
January 16, 2017: Scandinavian Journal of Medicine & Science in Sports
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