Kaloyan M Tsanov, Francisco M Barriga, Yu-Jui Ho, Direna Alonso-Curbelo, Geulah Livshits, Richard P Koche, Timour Baslan, Janelle Simon, Sha Tian, Alexandra N Wuest, Wei Luan, John E Wilkinson, Ignas Masilionis, Nevenka Dimitrova, Christine A Iacobuzio-Donahue, Ronan Chaligné, Dana Pe'er, Joan Massagué, Scott W Lowe
Driver gene mutations can increase the metastatic potential of the primary tumor 1-3 , but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations is inactivation of SMAD4 - a transcriptional effector of TGFβ signaling - which is a hallmark of multiple gastrointestinal malignancies 4,5 . SMAD4 inactivation mediates TGFβ's remarkable anti-to pro-tumorigenic switch during cancer progression and can thus influence both tumor initiation and metastasis 6-14 ...
March 18, 2024: bioRxiv