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Metastatic colon cancer

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https://www.readbyqxmd.com/read/28812983/a-microfluidic-platform-for-modeling-metastatic-cancer-cell-matrix-invasion
#1
Laura Blaha, Chentian Zhang, Mario Cabodi, Joyce Y Wong
Invasion of the extracellular matrix is a critical step in the colonization of metastatic tumors. The invasion process is thought to be driven by both chemokine signaling and interactions between invading cancer cells and physical components of the metastatic niche, including endothelial cells that line capillary walls and serve as a barrier to both diffusion and invasion of the underlying tissue. Transwell chambers, a tool for generating artificial chemokine gradients to induce cell migration, have facilitated recent work to investigate the chemokine contributions to matrix invasion...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28812429/metastatic-colon-adenocarcinoma-has-a-significantly-elevated-expression-of-il-10-compared-to-primary-colon-adenocarcinoma-tumors
#2
Michelle H Townsend, Abigail M Felsted, Stephen R Piccolo, Richard A Robison, Kim L O'Neill
Classical anti-inflammatory cytokines are known to play a role in both cancer progression as well as cancer elimination. We evaluated the anti-inflammatory cytokines IL-10 and TGF-β in patients with colon adenocarcinoma and metastatic colon adenocarcinoma utilizing immunohistochemical assays to determine the expression of the cytokines between various malignant tissues. We found tissues stained with TGF-β showed no significant upregulation within malignant tumors when compared to normal tissue controls. We observed high levels of TGF-β presence in most tissues similar to GAPDH expression...
August 16, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28811946/are-all-mutations-the-same-a-rare-case-report-of-coexisting-mutually-exclusive-kras-and-braf-mutations-in-a-patient-with-metastatic-colon-adenocarcinoma
#3
Anusha Vittal, Akshay Middinti, Anup Kasi Loknath Kumar
29-year-old Hispanic woman presented to the clinic with complaints of abdominal pain, nausea, fatigue, and constipation. Laboratory tests indicated the presence of iron deficiency anemia and transaminitis. Imaging evaluation revealed marked hepatomegaly with multiple hepatic metastases and pelvic lymphadenopathy. Biopsy of the hepatic lesions showed adenocarcinoma positive for pan-cytokeratin, CMA5.2, villin, and CDX2. She was positive for tumor markers CA 19-9, CA-125, and CEA. Upon further evaluation, she was found to have colorectal cancer positive for KRAS and BRAF mutations...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28811711/fibroblast-derived-cxcl12-sdf-1%C3%AE-promotes-cxcl6-secretion-and-co-operatively-enhances-metastatic-potential-through-the-pi3k-akt-mtor-pathway-in-colon-cancer
#4
Jia-Chi Ma, Xiao-Wen Sun, He Su, Quan Chen, Tian-Kang Guo, Yuan Li, Xiao-Chang Chen, Jin Guo, Zhen-Qiang Gong, Xiao-Dan Zhao, Jian-Bo Qi
AIM: To investigate the underlying mechanism by which CXCL12 and CXCL6 influences the metastatic potential of colon cancer and internal relation of colon cancer and stromal cells. METHODS: Western blotting was used to detect the expression of CXCL12 and CXCL6 in colon cancer cells and stromal cells. The co-operative effects of CXCL12 and CXCL6 on proliferation and invasion of colon cancer cells and human umbilical vein endothelial cells (HUVECs) were determined by enzyme-linked immunosorbent assay, and proliferation and invasion assays...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28810912/inhibition-of-trpm7-suppresses-cell-proliferation-of-colon-adenocarcinoma-in-vitro-and-induces-hypomagnesemia-in-vivo-without-affecting-azoxymethane-induced-early-colon-cancer-in-mice
#5
Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, F Kelly Galbraith Kawabata, David Horgen, Toshihiko Kawamori, Reinhold Penner, Andrea Fleig
BACKGROUND: Magnesium (Mg(2+)) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mg(2+) homeostasis. Abnormal expression of TRPM7 is found in numerous cancers, including colon, implicating TRPM7 in this process. METHODS: To establish a possible link between systemic magnesium (Mg(2+)) status, the Mg(2+) conducting channel TRPM7 in colon epithelial cells, and colon carcinogenesis, in vitro whole-cell patch clamp electrophysiology, qPCR, and pharmacological tools were used probing human colorectal adenocarcinoma HT-29 as well as normal primary mouse colon epithelial cells...
August 15, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28810142/control-of-metastasis-by-nk-cells
#6
REVIEW
Alejandro López-Soto, Segundo Gonzalez, Mark J Smyth, Lorenzo Galluzzi
The metastatic spread of malignant cells to distant anatomical locations is a prominent cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms that enable neoplastic cells to invade the local microenvironment, reach the circulation, and colonize distant sites, including the so-called epithelial-to-mesenchymal transition. Moreover, metastasis is regulated by microenvironmental and systemic processes, such as immunosurveillance. Here, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic dissemination, and present potential therapeutic approaches to prevent or target metastatic disease by harnessing NK cells...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28808503/prognostic-efficacy-of-inflammation-based-markers-in-patients-with-curative-colorectal-cancer-resection
#7
Özgür Akgül, Erdinç Çetinkaya, Metin Yalaza, Sabri Özden, Mesut Tez
AIM: To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and prognostic nutritional index (PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer. METHODS: 183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels (CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival (months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database...
July 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28805784/-short-term-outcomes-of-complete-mesocolic-excision-for-right-colon-cancer
#8
A O Rasulov, A G Malikhov, O A Rakhimov, N A Kozlov, O A Malikhova
PURPOSE: Complete mesocolic excision (CME) appears to be a relatively new concept for colon cancer. The purpose is to evaluate the results of CME with high vascular ligation (D3 lymph node dissection) for right colon cancer. The presented study identifies possible risks and advantages of the proposed method, as well as the role of the laparoscopic approach. MATERIAL AND METHODS: The article included data from 39 patients with right colon cancer, TNM stage I-III, operated on between November 2015 and December 2016 in the oncoproctology Department of the Blokhin Cancer Research Center...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28803067/ppargc1a-is-upregulated-and-facilitates-lung-cancer-metastasis
#9
Jin-Dong Li, Qing-Chuan Feng, Yu Qi, Guanghui Cui, Song Zhao
Lung cancer remains a leading cause of cancer-related mortality, with metastatic progression remaining the single largest cause of lung cancer mortality. Hence it is imperative to determine reliable biomarkers for lung cancer prognosis. We performed quantitative real-time PCR (qRT-PCR) analysis to explore epithelial-mesenchymal transition (EMT) inducers that regulate EMT process in three patients with advanced lung cancer disease. Peroxisome proliferator-activated receptor gamma (PPARGC1A) was uniformly the topmost overexpressed gene in all three human non-small cell lung cancer (NSCLC) patient samples...
August 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28782898/macf1-a-novel-potential-target-in-cancer
#10
REVIEW
Zhiping Miao, Arshad Ali, Lifang Hu, Fan Zhao, Chong Yin, Chu Chen, Tuanmin Yang, Airong Qian
Cancer is a polygenic disease characterized by uncontrolled growth of normal body cells, which exhibits deregulation of cell cycle as well as resistance to apoptosis and leads to metastasize into other parts of the body. The spectraplakin protein, microtubule actin cross-linking factor 1 (MACF1) plays an essential function in various cellular processes including cell proliferation, migrations, signaling transduction and embryo development. MACF1 is also involved in processes such as metastatic invasion in which cytoskeleton organization is a critical element that contributes to tumor progression in various human cancers...
August 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/28770169/investigation-of-metastasis-related-genes-a-rat-model-mimicking-liver-metastasis-of-colorectal-carcinoma
#11
REVIEW
Hassan Adwan, Rania Georges, Asim Pervaiz, Martin R Berger
Liver is the main target of colorectal cancer (CRC) metastasis. Currently, the number of reports is small, which describe changes in gene expression supporting liver metastasis. Here, a rat model was used for analyzing mRNA modulations during liver colonization and compared with available literature. In the model, CC531 rat CRC cells were injected via a mesenteric vein into isogenic WAG/Rij rats and re-isolated at early, intermediate, advanced, and terminal stages of liver colonization. These cells were used for RNA isolation...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28769567/thyroid-cancer-in-a-patient-with-lynch-syndrome-case-report-and-literature-review
#12
Monika Fazekas-Lavu, Andrew Parker, Allan D Spigelman, Rodney J Scott, Richard J Epstein, Michael Jensen, Katherine Samaras
Lynch syndrome describes a familial cancer syndrome comprising germline mutations in one of four DNA mismatch repair genes, MLH1, MSH2, MSH6, and PMS2 and is characterized by colorectal, endometrial, and other epithelial malignancies. Thyroid cancer is not usually considered to be part of the constellation of Lynch syndrome cancers nor have Lynch syndrome tumor gene mutations been reported in thyroid malignancies. This study reports a woman with Lynch syndrome (colonic cancer and a DNA mismatch repair mutation in the MSH2 gene) with a synchronous papillary thyroid cancer...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28769537/osteopontin-at-the-crossroads-of-inflammation-and-tumor-progression
#13
REVIEW
Luigi Mario Castello, Davide Raineri, Livia Salmi, Nausicaa Clemente, Rosanna Vaschetto, Marco Quaglia, Massimiliano Garzaro, Sergio Gentilli, Paolo Navalesi, Vincenzo Cantaluppi, Umberto Dianzani, Anna Aspesi, Annalisa Chiocchetti
Complex interactions between tumor and host cells regulate systemic tumor dissemination, a process that begins early at the primary tumor site and goes on until tumor cells detach themselves from the tumor mass and start migrating into the blood or lymphatic vessels. Metastatic cells colonize the target organs and are capable of surviving and growing at distant sites. In this context, osteopontin (OPN) appears to be a key determinant of the crosstalk between cancer cells and the host microenvironment, which in turn modulates immune evasion...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28765705/divergent-expression-of-bacterial-wall-sensing-toll-like-receptors-2-and-4-in-colorectal-cancer
#14
Karoliina Paarnio, Sara Väyrynen, Kai Klintrup, Pasi Ohtonen, Markus J Mäkinen, Jyrki Mäkelä, Tuomo J Karttunen
AIM: To characterize the expression of toll-like receptors (TLR) 2 and 4 in colorectal cancer (CRC) and in normal colorectal mucosa. METHODS: We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28762325/activation-of-vimentin-is-critical-to-promote-a-metastatic-potential-of-cholangiocarcinoma-cells
#15
Waraporn Saentaweesuk, Norie Araki, Kulthida Vaeteewoottacharn, Atit Silsirivanit, Wunchana Seubwai, Chutima Talabnin, Kanha Muisuk, Banchob Sripa, Sopit Wongkham, Seiji Okada, Chaisiri Wongkham
Cholangiocarcinoma (CCA) is a highly metastatic tumor, of which the majority of the patients have short survival due tono effective treatment. Hence, a better understanding regarding CCA metastasis may provide an opportunity to improve the strategies for treatment. A comparison study between the highly metastatic cells and their parental cells is an approach to uncover the molecular mechanisms underlying the metastatic process. In the present study, a lung metastatic CCA cell line, KKU-214L5 was established by the in vivo selection of the tail-vein injected mouse model...
July 25, 2017: Oncology Research
https://www.readbyqxmd.com/read/28757546/roles-of-wnt-target-genes-in-the-journey-of-cancer-stem-cells
#16
REVIEW
Jee-Heun Kim, So-Yeon Park, Youngsoo Jun, Ji-Young Kim, Jeong-Seok Nam
The importance of Wnt/β-catenin signaling in cancer stem cells (CSCs) has been acknowledged; however, the mechanism through which it regulates the biological function of CSCs and promotes cancer progression remains elusive. Hence, to understand the intricate mechanism by which Wnt controls stemness, the specific downstream target genes of Wnt were established by analyzing the genetic signatures of multiple types of metastatic cancers based on gene set enrichment. By focusing on the molecular function of Wnt target genes, the biological roles of Wnt were interpreted in terms of CSC dynamics from initiation to metastasis...
July 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28754664/identification-of-a-human-airway-epithelial-cell-subpopulation-with-altered-biophysical-molecular-and-metastatic-properties
#17
Paul C Pagano, Linh M Tran, Nawal Bendris, Sean O'Byrne, Henry T Tse, Shivani Sharma, Jonathan W Hoech, Stacy J Park, Elvira L Liclican, Zhe Jing, Rui Li, Kostyantyn Krysan, Manash K Paul, Yari Fontebasso, Jill E Larsen, Shaina Hakimi, Atsuko Seki, Michael C Fishbein, James K Gimzewski, Dino Di Carlo, John D Minna, Tonya C Walser, Steven M Dubinett
Lung cancers are documented to have remarkable intratumoral genetic heterogeneity. However, little is known about the heterogeneity of biophysical properties, such as cell motility, and its relationship to early disease pathogenesis and micrometastatic dissemination. In this study, we identified and selected a subpopulation of highly migratory premalignant airway epithelial cells that were observed to migrate through microscale constrictions at up to 100-fold the rate of the unselected immortalized epithelial cell lines...
July 28, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28751379/the-interleukin-like-epithelial-mesenchymal-transition-inducer-ilei-exhibits-a-non-interleukin-like-fold-and-is-active-as-a-domain-swapped-dimer
#18
Anna M Jansson, Agnes Csiszar, Joachim Maier, Ann-Christin Nyström, Elisabeth Ax, Patrik Johansson, Lovisa Holmberg Schiavone
Production and secretion of pro-metastatic proteins is a feature of many tumor cells. The FAM3C Interleukin-like epithelial-to-mesenchymal-transition (EMT) inducer, ILEI has been shown to be strongly up-regulated in several cancers and to be essential for tumor formation and metastasis in epithelial cells, correlating with a significant decrease in overall survival in colon and breast cancer patients. ILEI has been seen to interact with the γ-secretase presenilin 1 subunit (PS1). However, not much is known about the mechanism-of-action or the detailed ILEI structure...
July 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28750680/primary-tumor-location-as-a-predictor-of-the-benefit-of-palliative-resection-for-colorectal-cancer-with-unresectable-metastasis
#19
Rong-Xin Zhang, Wen-Juan Ma, Yu-Ting Gu, Tian-Qi Zhang, Zhi-Mei Huang, Zhen-Hai Lu, Yang-Kui Gu
BACKGROUND: It is still under debate that whether stage IV colorectal cancer patients with unresectable metastasis can benefit from primary tumor resection, especially for asymptomatic colorectal cancer patients. Retrospective studies have shown controversial results concerning the benefit from surgery. This retrospective study aims to evaluate whether the site of primary tumor is a predictor of palliative resection in asymptomatic stage IV colorectal cancer patients. METHODS: One hundred ninety-four patients with unresectable metastatic colorectal cancer were selected from Sun Yat-sen University Cancer Center Database in the period between January 2007 and December 2013...
July 27, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28750639/epithelial-requirement-for-in-vitro-proliferation-and-xenograft-growth-and-metastasis-of-mda-mb-468-human-breast-cancer-cells-oncogenic-rather-than-tumor-suppressive-role-of-e-cadherin
#20
H J Hugo, N P A D Gunasinghe, B G Hollier, T Tanaka, T Blick, A Toh, P Hill, C Gilles, M Waltham, E W Thompson
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epithelial transition (MET). We tested whether E-cadherin maintains epithelial proliferation in MDA-MB-468 breast cancer cells, facilitating metastatic colonization in severe combined immunodeficiency (SCID) mice. METHODS: EMT/MET markers were assessed in xenograft tumors by immunohistochemistry...
July 27, 2017: Breast Cancer Research: BCR
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