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morbidity pattern older people

S Chigogora, P Zaninotto, M Kivimaki, A Steptoe, G D Batty
Depressive disorders are a leading cause of disability in older age. Although the role of psychosocial and behavioural predictors has been well examined, little is known about the biological origins of depression. Findings from animal studies have implicated insulin-like growth factor 1 (IGF-1) in the aetiology of this disorder. A total of 6017 older adults (mean age of 65.7 years; 55% women) from the English Longitudinal Study of Ageing provided serum levels of IGF-1 (mean=15.9 nmol l(-1), s.d. 5.7) during a nurse visit in 2008...
September 20, 2016: Translational Psychiatry
Valérie Laurence, Maria Marples, Daniel P Stark
The pattern of cancer seen in young people changes with increasing age, transitioning from childhood- to adult-type cancer in adolescence and the third decade. The risk factors, presentation and biology of cancer in young adults differ from those in the older adult population. Factors of particular significance in adolescents and young adults (AYAs) include genetic predisposition to adult-type cancer, diagnostic uncertainty, long-term morbidity and considerations of fertility. New systemic therapies are being introduced that can prolong life and even increase the chance of cure, but the impact on AYAs is uncertain, as these patients are often under-represented in clinical trials...
2016: Progress in Tumor Research
Kieran Anthony Walsh, Niamh A O'Regan, Stephen Byrne, John Browne, David J Meagher, Suzanne Timmons
BACKGROUND: Neuropsychiatric Symptoms (NPS) are ubiquitous in dementia and are often treated pharmacologically. The objectives of this study were to describe the use of psychotropic, anti-cholinergic, and deliriogenic medications and to identify the prevalence of polypharmacy and psychotropic polypharmacy, among older hospitalized patients in Ireland, with and without dementia. METHODS: All older patients (≥ 70 years old) that had elective or emergency admissions to six Irish study hospitals were eligible for inclusion in a longitudinal observational study...
November 2016: International Psychogeriatrics
Vladimir Kartashev, Matthias Döring, Leonardo Nieto, Eleda Coletta, Rolf Kaiser, Saleta Sierra
BACKGROUND: HCV affects 185 million people worldwide and leads to death and morbidities. HCV has a high genetic diversity and is classified into seven genotypes and 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance and cure rates depend on HCV geno/subtype (GT). OBJECTIVES: Analysis of epidemiological information and viral GT from patients undergoing viral genotyping in 2011-2015. STUDY DESIGN: Anonymized information from 52 centers was analyzed retrospectively...
August 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Bishwajit Bhattacharya, Adrian Maung, Kevin Schuster, Kimberly A Davis
BACKGROUND: Trauma centers are seeing an increasing number of geriatric patients that are more susceptible to injuries even from relatively minor insults such as a ground level fall (GLF). As life expectancy increases, people are living in the geriatric age bracket for decades and often use anticoagulation agents for various comorbidities. We hypothesize that this patient population is not homogenous and we investigated the injury patterns and outcomes after GLF as a function of age and anticoagulation use...
September 2016: Injury
Bruno Pereira Nunes, Fabio Alberto Camargo-Figuera, Marília Guttier, Paula Duarte de Oliveira, Tiago N Munhoz, Alicia Matijasevich, Andréa Dâmaso Bertoldi, Fernando César Wehrmeister, Marysabel Pinto Telis Silveira, Elaine Thumé, Luiz Augusto Facchini
OBJECTIVES: The aim of this study was to evaluate occurrences and patterns of multimorbidity in adults from a southern Brazilian city. METHODS: A population-based cross-sectional study was carried out in 2012 through face-to-face interviews with adults (20 or more years) living in Pelotas, southern Brazil. Multimorbidity was evaluated by a list of 11 morbidities (based on medical diagnosis; Patient Health Questionnaire 9 for depression; and Anatomical Therapeutic Chemical index) and operationalized according to two cutoff points: ≥2 and ≥3 morbidities...
December 2016: International Journal of Public Health
Taofikat Agbabiaka, Barbara Wider, Leala Kay Watson, Claire Goodman
BACKGROUND: There has been a global increase in the use of herbal medicinal products (HMPs). About a quarter of UK adults use HMPs, bought over the counter by self-prescription and often not disclosed to healthcare professionals. Potential herb-drug interaction is a clinical concern, with older people at greater risk because of co-morbidities and slower clearance of pharmacologically active compounds. While there is a good understanding of general herbal medicine use by older people, less is known about the extent and implications of concurrent use with prescription medicines...
April 21, 2016: Systematic Reviews
Man Cheung Chung, Sabeena Jalal, Najib Ullah Khan
BACKGROUND: In literature, the effect of age on posttraumatic stress disorder (PTSD) is inconclusive; the effect on flood-related PTSD is particularly unclear. Little is known on distorted cognitions among flood victims, although cognition distortions and PTSD have been linked among victims of other traumas. AIMS: To investigate: (1) whether flood-related PTSD, psychiatric co-morbidity and cognitive distortions would differ according to age and (2) distinctive patterns of association between the preceding variables for different age groups...
March 3, 2016: Journal of Mental Health
Susanna Esposito, Daniela Mari, Luigi Bergamaschini, Annalisa Orenti, Leonardo Terranova, Luca Ruggiero, Valentina Ierardi, Monia Gambino, Francesco Della Croce, Nicola Principi
BACKGROUND: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. RESULTS: Among 417 adults ≥65 years old (171, 41...
2016: Immunity & Ageing: I & A
Aristithes G Doumouras, Fady Saleh, Scott Gmora, Mehran Anvari, Dennis Hong
OBJECTIVE: We evaluated regional access to bariatric surgery within the high-volume, center of excellence (COE) model of Ontario, Canada. BACKGROUND: In 2009, Ontario implemented Canada's first regionalized bariatric surgical care system based on a COE. Because of this, a small number of COEs service a large population and geographic area. METHODS: This study identified all patients older than 18 years, who received bariatric surgery from April 2009 to March 2012...
February 2016: Annals of Surgery
Kilian Wistuba-Hamprecht, Karin Haehnel, Nicole Janssen, Ilja Demuth, Graham Pawelec
BACKGROUND: Aging and latent infection with Cytomegalovirus (CMV) are thought to be major factors driving the immune system towards immunosenescence, primarily characterized by reduced amounts of naïve T-cells and increased memory T-cells, potentially associated with higher morbidity and mortality. The composition of both major compartments, γδ as well as αβ T-cells, is altered by age and CMV, but detailed knowledge of changes to the γδ subset is currently limited. RESULTS: Here, we have surveyed a population of 73 younger (23-35 years) and 144 older (62-85 years) individuals drawn from the Berlin Aging Study II, investigating the distribution of detailed differentiation phenotypes of both γδ and αβ T-cells...
2015: Immunity & Ageing: I & A
Nigar Nargis, Mary E Thompson, Geoffrey T Fong, Pete Driezen, A K M Ghulam Hussain, Ummul H Ruthbah, Anne C K Quah, Abu S Abdullah
BACKGROUND: Smoking and passive smoking are collectively the biggest preventable cause of death in Bangladesh, with major public health burden of morbidity, disability, mortality and community costs. The available studies of tobacco use in Bangladesh, however, do not necessarily employ nationally representative samples needed to monitor the problem at a national scale. This paper examines the prevalence and patterns of tobacco use among adults in Bangladesh and the changes over time using large nationally representative comparable surveys...
2015: PloS One
Magnus Sandberg, Gerd Ahlström, Jimmie Kristensson
BACKGROUND: Knowledge about diagnoses patterns in older people with intellectual disabilities is limited. METHODS: The case group (n = 7936) comprised people with intellectual disabilities aged 55 years and older. The control group (n = 7936) was age matched and sex matched. Somatic inpatient diagnoses (2002-2012) were collected retrospectively. RESULTS: Several diagnoses were in several years significantly more common in the case group, particularly infections [odds ratio (OR) 1...
January 2017: Journal of Applied Research in Intellectual Disabilities: JARID
Fabian P Held, Fiona Blyth, Danijela Gnjidic, Vasant Hirani, Vasikaran Naganathan, Louise M Waite, Markus J Seibel, Jennifer Rollo, David J Handelsman, Robert G Cumming, David G Le Couteur
BACKGROUND: Comorbidity and multimorbidity are common in older people. Here we used a novel analytic approach called Association Rules together with network analysis to evaluate multimorbidity (two or more disorders) and comorbidity in old age. METHODS: A population-based cross-sectional study was undertaken where 17 morbidities were analyzed using network analysis, cluster analysis, and Association Rules methodology. A comorbidity interestingness score was developed to quantify the richness and variability of comorbidities associated with an index condition...
May 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Martin Frisher, Marina Mendonça, Nicola Shelton, Hynek Pikhart, Cesar de Oliveira, Clare Holdsworth
BACKGROUND: Increases in alcohol related mortality and morbidity have been reported among older people in England over the last decade. There is, however, evidence that drinking is protective for some health conditions. The validity of this evidence has been questioned due to residual confounding and selection bias. The aim of this study is to clarify which drinking profiles and other demographic characteristics are associated with poor self-rated health among a community-based sample of older adults in England...
2015: BMC Public Health
Mikaela Smit, Kees Brinkman, Suzanne Geerlings, Colette Smit, Kalyani Thyagarajan, Ard van Sighem, Frank de Wolf, Timothy B Hallett
BACKGROUND: The population infected with HIV is getting older and these people will increasingly develop age-related non-communicable diseases (NCDs). We aimed to quantify the scale of the change and the implications for HIV care in the Netherlands in the future. METHODS: We constructed an individual-based model of the ageing HIV-infected population, which followed patients on HIV treatment as they age, develop NCDs-including cardiovascular disease (hypertension, hypercholesterolaemia, myocardial infarctions, and strokes), diabetes, chronic kidney disease, osteoporosis, and non-AIDS malignancies-and start co-medication for these diseases...
July 2015: Lancet Infectious Diseases
Matthew A Brodie, Stephen R Lord, Milou J Coppens, Janneke Annegarn, Kim Delbaere
OBJECTIVES: Develop algorithms to detect gait impairments remotely using data from freely worn devices during long-term monitoring. Identify statistical models that describe how gait performances are distributed over several weeks. Determine the data window required to reliably assess an increased propensity for falling. METHODS: 1085 days of walking data were collected from eighteen independent-living older people (mean age 83 years) using a freely worn pendant sensor (housing a triaxial accelerometer and pressure sensor)...
November 2015: IEEE Transactions on Bio-medical Engineering
Katarzyna Szarc vel Szic, Ken Declerck, Melita Vidaković, Wim Vanden Berghe
The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, arthritis, and dementia. The heterogeneity in biological aging, chronological age, and aging-associated disorders in humans have been ascribed to different genetic and environmental factors (i.e., diet, pollution, stress) that are closely linked to socioeconomic factors...
2015: Clinical Epigenetics
Worku Tefera, Hailu Tesfaye, Elias Kayessa, Karen Z Waltensperger, Yenealem Tadesse, David R Marsh
BACKGROUND: The incidence of newborn and young infant health danger signs is unknown in Ethiopia. Neverthe- less, experience shows that care-seeking is far lower than conservative morbidity estimates would project. OBJECTIVES: To examine illness recognition, home care, decision-making, and care-seeking for sick infants less than two months of age in Shebedino District, Southern Nations, Nationalities and Peoples Region in 2011. METHODS: Focus group interviews of mothers (n = 60) of recently ill children...
October 2014: Ethiopian Medical Journal
Sanna Read, Emily Grundy, Else Foverskov
OBJECTIVES: Previous studies of older European populations have established that disability and morbidity vary with indicators of socio-economic position (SEP). We undertook a systematic narrative review of the literature to ascertain to what extent there is evidence of similar inequalities in the subjective health and well-being of older people in Europe. METHOD: Relevant original research articles were searched for using Medline, Global Health, Embase, Social Policy and Practice, Cinahl, Web of Science and International Bibliography of the Social Sciences (IBSS)...
2016: Aging & Mental Health
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