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Darren Fitzpatrick, Jeremy Grubin
Because of the widespread use of eponyms and acronyms to describe labroligamentous findings in the shoulder, interpreting shoulder magnetic resonance imaging reports can be challenging. A summary of the appearance of these lesions on shoulder magnetic resonance images can help the orthopedic surgeon to understand these entities as imaging findings and to determine the appropriate treatment for patients with shoulder injuries.
February 2016: American Journal of Orthopedics
Jeremy Grubin, Alex Maderazo, Darren Fitzpatrick
Superior labral anteroposterior (SLAP) tears are common injuries that are best evaluated with magnetic resonance arthrography (MRA), as it provides the most detailed evaluation of the bicipital labral complex. Given the variety and complexity of SLAP tears, distention of the joint with intra-articular dilute gadolinium contrast properly separates the intra-articular biceps tendon, superior labrum, glenoid cartilage and glenohumeral ligaments to optimize assessment of these structures. This allows for increased diagnostic confidence of the interpreting radiologist and provides a better road map for the surgeon prior to arthroscopy...
October 2015: American Journal of Orthopedics
Lucy W Kappel, Gabrielle L Goldberg, Christopher G King, David Y Suh, Odette M Smith, Cassandra Ligh, Amanda M Holland, Jeremy Grubin, Nicholas M Mark, Chen Liu, Yoichiro Iwakura, Glenn Heller, Marcel R M van den Brink
CD4(+) interleukin-17 (IL-17)(+) T cells (Th17 cells) have been implicated in allograft rejection of solid organs and several autoimmune diseases. However, the functional role of Th17 cells in the development of acute graft-versus-host disease (GVHD) has not been well-characterized. We detected significant numbers of alloreactive CD4(+) donor T cells expressing IL-17, IL-17F, or IL-22 in the lymphoid organs of recipients of an allogeneic bone marrow transplant. We found no differences in GVHD mortality or graft-versus-tumor (GVT) activity between wild type (WT) and IL-17(-/-) T-cell recipients...
January 22, 2009: Blood
S Onder Alpdogan, Sydney X Lu, Neel Patel, Suzanne McGoldrick, David Suh, Tulin Budak-Alpdogan, Odette M Smith, Jeremy Grubin, Christopher King, Gabrielle L Goldberg, Vanessa M Hubbard, Adam A Kochman, Marcel R M van den Brink
Delayed T-cell recovery is an important complication of allogeneic bone marrow transplantation (BMT). We demonstrate in murine models that donor BM-derived T cells display increased apoptosis in recipients of allogeneic BMT with or without GVHD. Although this apoptosis was associated with a loss of Bcl-2 and Bcl-X(L) expression, allogeneic recipients of donor BM deficient in Fas-, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)- or Bax-, or BM-overexpressing Bcl-2 or Akt showed no decrease in apoptosis of peripheral donor-derived T cells...
December 1, 2008: Blood
Johannes L Zakrzewski, David Suh, John C Markley, Odette M Smith, Christopher King, Gabrielle L Goldberg, Robert Jenq, Amanda M Holland, Jeremy Grubin, Javier Cabrera-Perez, Renier J Brentjens, Sydney X Lu, Gabrielle Rizzuto, Derek B Sant'Angelo, Isabelle Riviere, Michel Sadelain, Glenn Heller, Juan Carlos Zúñiga-Pflücker, Chen Lu, Marcel R M van den Brink
We present a strategy for adoptive immunotherapy using T-lineage committed lymphoid precursor cells generated by Notch1-based culture. We found that allogeneic T-cell precursors can be transferred to irradiated individuals irrespective of major histocompatibility complex (MHC) disparities and give rise to host-MHC restricted and host-tolerant functional allogeneic T cells, improving survival in irradiated recipients as well as enhancing anti-tumor responses. T-cell precursors transduced to express a chimeric receptor targeting hCD19 resulted in significant additional anti-tumor activity, demonstrating the feasibility of genetic engineering of these cells...
April 2008: Nature Biotechnology
Theo D Kim, Theis H Terwey, Johannes L Zakrzewski, David Suh, Adam A Kochman, Megan E Chen, Chris G King, Chiara Borsotti, Jeremy Grubin, Odette M Smith, Glenn Heller, Chen Liu, George F Murphy, Onder Alpdogan, Marcel R M van den Brink
Dendritic cells (DCs) are considered critical for the induction of graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In addition to their priming function, dendritic cells have been shown to induce organ-tropism through induction of specific homing molecules on T cells. Using adoptive transfer of CFSE-labeled cells, we first demonstrated that alloreactive T cells differentially up-regulate specific homing molecules in vivo. Host-type dendritic cells from the GVHD target organs liver and spleen or skin- and gut-draining lymph nodes effectively primed naive allogeneic T cells in vitro with the exception of liver-derived dendritic cells, which showed less stimulatory capacity...
March 1, 2008: Blood
Teresa Ramirez-Montagut, Andrew Chow, Adam A Kochman, Odette M Smith, David Suh, Hamad Sindhi, Sydney Lu, Chiara Borsotti, Jeremy Grubin, Neel Patel, Theis H Terwey, Theo D Kim, Glenn Heller, George F Murphy, Chen Liu, Onder Alpdogan, Marcel R M van den Brink
To determine the mechanisms of graft-versus-tumor (GVT) activity in the absence of graft-versus-host disease (GVHD) against a solid tumor, we established two allogeneic bone marrow transplantation models with a murine renal cell carcinoma (RENCA). The addition of 0.3 x 10(6) donor CD8(+) T cells to the allograft increased the survival of tumor-bearing mice without causing GVHD. The analysis of CD8(+) T cells deficient in cytotoxic molecules demonstrated that anti-RENCA activity is dependent on IFN-gamma and Fas ligand (FasL), but does not require soluble or membrane-bound TNF-alpha, perforin, or TRAIL...
August 1, 2007: Journal of Immunology: Official Journal of the American Association of Immunologists
Johannes L Zakrzewski, Adam A Kochman, Sydney X Lu, Theis H Terwey, Theo D Kim, Vanessa M Hubbard, Stephanie J Muriglan, David Suh, Odette M Smith, Jeremy Grubin, Neel Patel, Andrew Chow, Javier Cabrera-Perez, Radhika Radhakrishnan, Adi Diab, Miguel-Angel Perales, Gabrielle Rizzuto, Ewa Menet, Eric G Pamer, Glen Heller, Juan Carlos Zúñiga-Pflücker, Onder Alpdogan, Marcel R M van den Brink
Immunoincompetence after allogeneic hematopoietic stem cell transplantation (HSCT) affects in particular the T-cell lineage and is associated with an increased risk for infections, graft failure and malignant relapse. To generate large numbers of T-cell precursors for adoptive therapy, we cultured mouse hematopoietic stem cells (HSCs) in vitro on OP9 mouse stromal cells expressing the Notch-1 ligand Delta-like-1 (OP9-DL1). We infused these cells, together with T-cell-depleted mouse bone marrow or purified HSCs, into lethally irradiated allogeneic recipients and determined their effect on T-cell reconstitution after transplantation...
September 2006: Nature Medicine
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