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https://www.readbyqxmd.com/read/29764036/-comparison-of-prognostic-value-of-18-f-fdg-pet-ct-myocardial-metabolism-imaging-and-coronary-collateral-circulation-in-patients-with-cto-lesions
#1
G Y Zhai, J L Wang, Y Y Liu, Y J Zhou
Objective: To evaluate the location, extent of viable myocardial of chronic total coronary occlusions(CTO)lesions by (18)F-FDG PET myocardial metabolism imaging and then compare with coronary collateral circulation(CCC) to evaluate the prognostic evaluation in patients with CTO lesions. Methods: A total of Sixty consecutive patients with CTO lesions referred for viability assessment from April 2016 to April 2017 in Department of Cardiology, Beijing Anzhen Hospital were included in the study. These patients underwent (99m)Tc-sestamibi ECG-gated SPECT rest myocardial perfusion imaging and ECG-gated (18)F-FDG PET/CT myocardial metabolic imaging, as well as coronary arteriography were recruited in this study...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29757564/-re-operation-treatment-in-uremic-patients-complicated-with-persistent-secondary-hyperparathyroidism-after-parathyroidectomy-with-autotransplantation
#2
Shao Jun Bo, Xian Fa Xu, Chuan Ya Qiu, Tian Tian Wang, Yu Dong Ning, Hong Yue Li
Objective: To analyze the clinical profile and therapeutic effect of re-operation treatment in uremic patients complicated with persistent secondary hyperparathyroidism(SHPT)after parathyroidectomy with autotransplantation. Method: Twelve persistent SHPT patients who were treated with reoperation of paramyroidectomy(PTX)were enrolled in this study during the period from Jan 2014 to Jul 2017 in our hospital.We evaluated the location of the remaining parathyroid glands by ultrasonography,dual-phase 99 Tcm-sestamibi scintigraphy,CT and MR imaging of the neck before the operation...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29742603/progression-of-multiple-myeloma-detected-on-cardiac-scintigraphy-with-99mtc-sestamibi
#3
Jonathan Bulzan, Jonathan Revels, Kathy Byun
It is important to understand normal and abnormal radiotracer biodistribution patterns in patients who undergo cardiac Tc-2-methoxyisobutyl-isonitrile (Tc-sestamibi) scans to provide important clinical guidance. Our case describes a 75-year-old man with a history of multiple myeloma in remission, who presented to the emergency department for unrelated chest pain and shortness of breath. The patient underwent a nuclear cardiac stress test with Tc-sestamibi scintigraphy as part of his cardiac workup. The images demonstrated diffuse radiotracer uptake in the skeletal structures raising concern for progression of multiple myeloma, of which, subsequent biopsy confirmed the presence of recurrent disease...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29736849/diagnostic-accuracy-of-3t-magnetic-resonance-imaging-in-the-preoperative-localisation-of-parathyroid-adenomas-comparison-with-ultrasound-and-99mtc-sestamibi-scans
#4
Renato Argirò, Daniele Diacinti, Beatrice Sacconi, Angelo Iannarelli, Davide Diacinti, Cristiana Cipriani, Daniela Pisani, Elisabetta Romagnoli, Marco Biffoni, Cira Di Gioia, Jessica Pepe, Mario Bezzi, Claudio Letizia, Salvatore Minisola, Carlo Catalano
OBJECTIVES: To evaluate the diagnostic performance of 3TMRI in comparison with ultrasound (US) and 99mTc-sestamibi scan for presurgical localisation of parathyroid adenomas (PTAs) in patients with primary hyperparathyroidism (PHPT). METHODS: Fifty-seven patients affected by PHPT were prospectively enrolled and underwent US, 99mTc-sestamibi and 3TMRI. T2-weighted and post-contrast T1-weighted Iterative decomposition of water and fat with Echo Asymmetry and Least squares estimation (IDEAL) sequences were acquired...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29735505/osteitis-fibrosa-cystica-masquerading-as-bone-neoplasm
#5
Vishnu Vardhan Garla, Israh Akhtar, Sohail Salim, Angela Subauste
A 50-year-old female patient with no significant medical history presented with left knee pain. Radiographs of the knee showed a circumferential swelling of the distal femur suggestive of neoplasia. Further evaluation revealed multiple lesions in the left iliac bone and proximal femur. Biopsy was suggestive of a reparative granuloma or an aneurysmal bone cyst. Laboratory assessment showed hypercalcaemia and elevated parathyroid hormone consistent with severe primary hyperparathyroidism. Osseous survey was significant for salt and pepper appearance of the skull...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29700129/regional-myocardial-perfusion-disturbance-in-experimental-chronic-chagas-cardiomyopathy
#6
Luciano F L Oliveira, James T Thackeray, José A Marin Neto, Minna M D Romano, Eduardo E V Carvalho, Jorge Mejia, Denise M Tanaka, Grace K Silva, Douglas R Abdalla, Carlos Malamut, Frank M Bengel, Maria L Higuchi, André Schmidt, Edécio Cunha-Neto, Marcus V Simões
Background: Altered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of myocardial perfusion defects (MPD) and the correlated regional changes to histology in an experimental model of CCC in hamsters. Methods: Female Syrian hamsters ( n = 34) were infected with 3.5x104 to 105 trypomastigote forms of T. cruzi Y-strain and 6 to 10 months afterwards were submitted to in vivo imaging including: rest 99m Tc-sestamibi SPECT imaging, segmental and global left ventricular (LV) function assessment by using 2D-echocardiogram, and 18 F-FDG PET for evaluation of myocardial viability...
April 26, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29699804/preoperative-localization-modalities-in-primary-hyperparathyroidism-correlation-with-postoperative-cure
#7
Abbas Al-Kurd, Barak Levit, May Assaly, Ido Mizrahi, Haggi Mazeh, Michal Mekel
BACKGROUND: Accurate preoperative localization is critical to the success of minimally invasive parathyroidectomy. This investigation aimed to assess the correlation among preoperative imaging results, intraoperative findings, and postoperative cure rates in patients undergoing operation for primary hyperparathyroidism. METHODS: A retrospective review of all patients who underwent operation for primary hyperparathyroidism between June 2010 and March 2016 was performed...
April 23, 2018: Surgery
https://www.readbyqxmd.com/read/29696485/relationship-between-microvascular-changes-autonomic-denervation-and-myocardial-fibrosis-in-chagas-cardiomyopathy-evaluation-by-mri-and-spect-imaging
#8
Gustavo Canavaci Barizon, Marcus Vinicius Simões, André Schmidt, Leonardo Pippa Gadioli, Luiz Otávio Murta Junior
BACKGROUND: The relationship between microvasculopathy, autonomic denervation, and myocardial fibrosis, in Chagas cardiomyopathy is incompletely understood. The aim of this study was to explore the relative extent and anatomic distribution of myocardial hypoperfusion, autonomic denervation, and myocardial scarring using Single-Photon Emission Computerized Tomography (SPECT) imaging and Magnetic Resonance Imaging (MRI). METHODS: Thirteen patients with Chagas disease all had Iodine-123-metaiodobenzylguanidine (MIBG) SPECT, 99m Tc-Sestamibi (MIBI) rest-stress SPECT, and gadolinium late enhancement MRI imaging within a 2-month interval...
April 25, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29680989/challenging-pre-surgical-localization-of-hyperfunctioning-parathyroid-glands-in-primary-hyperparathyroidism-the-added-value-of-18-f-fluorocholine-pet-ct
#9
Serena Grimaldi, Jacques Young, Peter Kamenicky, Dana Hartl, Marie Terroir, Sophie Leboulleux, Amandine Berdelou, Julien Hadoux, Segolene Hescot, Hervé Remy, Eric Baudin, Martin Schlumberger, Désirée Deandreis
PURPOSE: To evaluate the added value of 18 F-Fluorocholine (18 F-FCH) PET/CT in presurgical imaging of patients with primary hyperparathyroidism (HPT) and challenging localization of the hyper-functioning parathyroid glands. METHODS: We included 27 consecutive patients with primary HPT (19 F; median age: 58 years), with either (i) non-conclusive pre-surgical localization with 99 mTc-sestaMIBI scintigraphy and neck ultrasonography (US), (ii) recurrence of previously operated HPT, or (iii) familiar HPT with a suspicion of multiple gland disease...
April 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29679191/myocardial-flow-reserve-derived-by-dynamic-perfusion-single-photon-emission-computed-tomography-reflects-the-severity-of-coronary-atherosclerosis
#10
Nobuo Iguchi, Yuko Utanohara, Yasuhiro Suzuki, Makoto Suzuki, Kenichi Hagiya, Ryosuke Higuchi, Itaru Takamisawa, Tetsuya Tobaru, Tetsuya Sumiyoshi, Mitsuaki Isobe
A novel single-photon emission computed tomography (SPECT) camera was developed to evaluate dynamic myocardial perfusion flow. However, it is unclear whether myocardial flow reserve (MFR) derived by dynamic perfusion SPECT using the novel SPECT camera (D-SPECT) reflects the severity of coronary atherosclerosis. In the present study, we therefore examined the relationship between MFR using D-SPECT and severity of coronary lesions. The study population comprised 40 patients who underwent both a myocardial dynamic perfusion SPECT study and invasive coronary angiography...
April 20, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29666107/tc-99m-sestamibi-scintigraphy-and-primary-hyperparathyroidism-uptake-beyond-parathyroid-glands
#11
Daniela Dias, Joana Simões-Pereira, Valeriano Leite
No abstract text is available yet for this article.
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29656552/better-performance-of-four-dimension-computed-tomography-as-a-localization-procedure-in-normocalcemic-primary-hyperparathyroidism
#12
Phelipe Cunha-Bezerra, Ricardo Vieira, Fernando Amaral, Henrique Cartaxo, Túlio Lima, Ulisses Montarroyos, Francisco Bandeira
INTRODUCTION: The multi-phase or four-dimensional computed tomography (4D CT) has emerged as a promising technique for preoperative localization of parathyroid lesions in patients with primary hyperparathyroidism (PHPT), but little is known about its accuracy in patients with normocalcemic primary hyperparathyroidism (NPHPT). METHODS: A total of 18 patients diagnosed with PHPT underwent three methods of preoperative localization (4D CT, TC-99-Sestamibi scintigraphy and ultrasonography)...
April 15, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#13
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29629803/dynamic-ct-for-parathyroid-adenoma-detection-how-does-radiation-dose-compare-with-nuclear-medicine
#14
Caroline A Czarnecki, Paul F Einsiedel, Pramit M Phal, Julie A Miller, Meir Lichtenstein, Damien L Stella
OBJECTIVE: Dynamic CT is increasingly used for preoperative localization of parathyroid adenomas, but concerns remain about the radiation effective dose of CT compared with that of 99m Tc-sestamibi scintigraphy. The purpose of this study was to compare the radiation dose delivered by three-phase dynamic CT with that delivered by 99m Tc-sestamibi SPECT/CT performed in accordance with our current protocols and to assess the possible reduction in effective dose achieved by decreasing the scan length (i...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29625886/evaluation-of-staff-radiation-exposure-during-transthoracic-echocardiography-close-to-myocardial-perfusion-imaging
#15
Samia Massalha, Rachel Lugassi, Elyahu Raysberg, Amjad Koskosi, Gerson Lechtenberg, Ora Israel, John A Kennedy
BACKGROUND: Transthoracic echocardiography (TTE) and myocardial perfusion imaging (MPI) are used in cardiac patients. In this study the radiation exposure of sonographers performing TTE following MPI was evaluated. METHODS: Of 40 study patients, 30 underwent same-day 99m Tc sestamibi MPI and TTE, while another 10 underwent only TTE. Patients who underwent both studies were divided into three groups: right-handed TTE performed by an echocardiographer and right- and left-handed TTE performed by a cardiac sonographer...
April 3, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29599399/molecular-breast-imaging-administered-activity-does-not-require-adjustment-based-on-patient-size
#16
Thuy D Tran, Lacey R Ellingson, Tiffinee N Swanson, Courtney M Solberg, Michael K O'Connor, Carrie B Hruska
Objective: At our institution, MBI is performed with 300 MBq Tc-99m sstamibi for all patients. For some nuclear medicine procedures, administered activity or imaging time is increased for patients of larger size in order to obtain adequate counts. Our objective was to assess whether uptake of Tc-99m sestamibi in the breast is influenced by patient size. Methods: Records from patients who underwent a clinical MBI examination between July - November 2016 were reviewed. Those in whom our standard injection and preparation techniques were followed were included in the analysis [3,4]...
March 29, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29592976/localisation-of-ectopic-mediastinal-parathyroid-adenoma-by-18f-fluorocholine-pet-ct
#17
Maria Triantafyllidou, Klaus Strobel, Alfred Leiser, Stefan Fischli
We report the case of two patients with newly diagnosed primary hyperparathyroidism: a 40-year-old woman during pregnancy and a 60-year-old man with initial hypercalcaemic crisis. In the first case, a bilateral neck exploration with parathyroidectomy during the second trimester of pregnancy was unsuccessful and the patient remained hypercalcaemic. Postpartum imaging assessment with technetium (99m Tc)-sestamibi scintigraphy could not supply conclusive diagnostic results. The use of18 F-fluorocholine (FCH) positron emission tomography (PET)/CT provided the accurate localisation of an ectopic parathyroid adenoma in the anterior mediastinum which was successfully resected by a thoracoscopic approach...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29573598/clinical-value-of-11c-methionine-positron-emission-tomography-in-persistent-primary-hyperparathyroidism-a-case-report-with-a-mediastinal-parathyroid-adenoma
#18
M L Møller, L Rejnmark, A K Arveschoug, A Højsgaard, L Rolighed
INTRODUCTION: Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by pathologic growth of one or more of the parathyroid glands. Parathyroidectomies (PTX) in patients with PHPT are procedures with low morbidity, few complications, and a high cure rate. However, the parathyroid glands may be found at various anatomical locations and occasionally they are intrathoracic. CASE PRESENTATION: We present a 57-year-old patient with PHPT. Before the first and second operation, the preoperative imaging indicated pathologic parathyroid tissue in the neck...
March 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29572848/experimental-validation-of-absolute-spect-ct-quantification-for-response-monitoring-in-breast-cancer
#19
Angela Collarino, Lenka M Pereira Arias-Bouda, Renato A Valdés Olmos, Pieternel van der Tol, Petra Dibbets-Schneider, Lioe-Fee de Geus-Oei, Floris Hp van Velden
PURPOSE: Recent developments in iterative image reconstruction enable absolute quantification of SPECT/CT studies by incorporating compensation for collimator-detector response, attenuation and scatter as well as resolution recovery into the reconstruction process (Evolution; Q.Metrix package; GE Healthcare). The aim of this experimental study is to assess its quantitative accuracy for potential clinical 99m Tc-sestamibi (MIBI)-related SPECT/CT application in neoadjuvant chemotherapy response studies in breast cancer...
March 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29561475/study-of-the-peak-splitting-in-an-alternative-method-for-the-radiochemical-purity-measurement-of-99mtechnetium-sestamibi
#20
Manuel Montoza-Aguado, Carlos Salgado-García, Luis Falcón-Márquez, Ana Luna-Alcaide, Amelia Jiménez-Heffernan, Carmen Puentes-Zarzuela
One of the alternative methods for the measurement of radiochemical purity (RCP) of Technetium-sestamibi uses Whatman 3MM paper as the stationary phase and ethyl acetate as the mobile phase. However, alternative method shows peak splitting and shouldering of the radiopharmaceutical. This could be because of higher levels of analyte. We aimed to assess the effect of sample dilution (1 : 1) on this method and to compare these RCP values with the reference method. The diluted samples showed a unique peak in the radiopharmaceutical zone, but the RCP values were significantly different (P<0...
March 20, 2018: Nuclear Medicine Communications
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