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https://www.readbyqxmd.com/read/28546708/unilateral-exploration-for-parathyroid-adenoma
#1
Maddibande Ramachar Sreevathsa, Khyati Melanta
Between January 2012 to 2016, 20 patients with primary hyperparathyroidism underwent surgical exploration for presumed diagnosis of parathyroid adenoma. Nineteen patients underwent ultrasonography of neck and USG was found to be accurate in localizing the adenoma in 84.2%. Seventeen patients underwent sestamibi isotope scanning and imaging correlated with operative findings in 94.1%. Combined accuracy of ulrasound and sestamibi scan which was done in 17 patients was 95%. Seventeen patients underwent unilateral exploration and there was resolution of disease in 94...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28543268/sensitivity-of-3-dimensional-sonography-in-preoperative-evaluation-of-parathyroid-glands-in-patients-with-primary-hyperparathyroidism
#2
Susan J Frank, Adam E Goldman-Yassen, Tova Koenigsberg, Steven K Libutti, Mordecai Koenigsberg
OBJECTIVES: Preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism facilitates targeted surgery. We assessed the sensitivity of 3-dimensional (3D) sonography for preoperative localization of abnormal parathyroid glands. METHODS: We conducted a retrospective review of patients who underwent parathyroidectomy for primary hyperparathyroidism at a single site at our institution. We compared preoperative 2-dimensional (2D) sonography, 3D sonography, and sestamibi scans with final gland localization at surgery...
May 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28522742/evaluation-of-radiopharmaceutical-adverse-reaction-reports-to-the-british-nuclear-medicine-society-for-the-period-2007-to-2016
#3
Tracia-Gay Kennedy-Dixon, Maxine Gossell-Williams, Margaret Cooper, Moez Trabelsi, Sobhan Vinjamuri
Objective: This study sought to answer the calls for the restoration of reports of adverse reactions from the European Association of Nuclear Medicine. It assessed reports of adverse reactions to radiopharmaceuticals (ARRPs) that were submitted to the British Nuclear Medicine Society's (BNMS) Radiopharmaceutical Adverse Reactions and Product Defects online database during the period January 2007 to December 2016. Methodology: This investigation was a pharmacovigilance based, non-experimental, cross-sectional study aimed at finding the prevalence and association between radiopharmaceuticals and adverse reactions...
May 18, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28512723/low-dose-dual-isotope-procedure-planed-for-myocardial-perfusion-czt-spect-and-assessed-through-a-head-to-head-comparison-with-a-conventional-single-isotope-protocol
#4
Laetitia Imbert, Véronique Roch, Charles Merlin, Wassila Djaballah, Florent Cachin, Mathieu Perrin, Marine Claudin, Antoine Verger, Henri Boutley, Gilles Karcher, Pierre-Yves Marie
PURPOSE OF THE REPORT: This study aimed at assessing an original low-dose dual-isotope procedure in which the abnormal stress Tc-99m Sestamibi SPECT is followed by rest Tl-201 SPECT, along with a head-to-head comparison with a single-isotope procedure. METHODS AND RESULTS: One hundred two patients, referred for a low-dose stress-SPECT with Sestamibi (123 ± 20 MBq) on a CZT camera and for whom a rest Sestamibi SPECT was warranted, had an additional Tl-201 rest-SPECT (52 ± 5 MBq) between stress and rest Sestamibi SPECT recordings...
May 16, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28506419/radioguided-thyroidectomy-for-follicular-tumors-multicentric-experience
#5
D Parmeggiani, C Gambardella, R Patrone, A Polistena, M De Falco, R Ruggiero, R Cirocchi, A Sanguinetti, V Cuccurullo, M Accardo, N Avenia, G Docimo, S Tolone, V Bassi, L Docimo, G Conzo
BACKGROUND: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506410/effectiveness-of-intraoperative-parathyroid-monitoring-iopth-in-predicting-a-multiglandular-or-malignant-parathyroid-disease
#6
C Dobrinja, G Santandrea, M Giacca, Elisabetta Stenner, Maurizio Ruscio, Nicolò de Manzini
AIM: The main goal of our study was to confirm the usefulness of intra-operative parathyroid hormone (PTH) monitoring (ioPTH) when using minimally invasive techniques for treatment of sporadic Primary hyperparathyroidism (pHTP). Furthermore, we aimed to evaluate if ioPTH monitoring may help to predict the etiology of primary hyperparathyroidism, especially in malignant or multiglandular parathyroid disease. METHODS: A retrospective review of 125 consecutive patients with pHPT who underwent parathyroidectomy between 2001 and 2016 at the Department of General Surgery was performed...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28490354/dual-time-point-myocardial-18-f-fdg-imaging-in-the-detection-of-coronary-artery-disease
#7
Ke-Fei Dou, Xiao-Jin Gao, Bo-Qia Xie, Yan Li, Zuo-Xiang He, Min-Fu Yang
BACKGROUND: Myocardial (18)F-deoxyglucose ((18)F-FDG) uptake has been observed to be enhanced in patients with coronary artery disease (CAD) under fasting conditions. However, whether the increased (18)F-FDG is induced by myocardial ischemia and how to discriminate ischemic from physiological (18)F-FDG uptake have rarely been investigated. METHODS: Under fasting conditions, (18)F-FDG PET imaging was performed in 52 patients with suspected CAD. Two (18)F-FDG imaging sessions were conducted within two hours after a single administration of (18)F-FDG (dual-time-point imaging), and with an intervention of an exercise test after the first imaging...
May 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28480673/four-dimensional-computed-tomography-4dct-for-preoperative-localization-of-parathyroid-adenomas
#8
Abdel-Rauf Zeina, Helit Nakar, Nadir Reindorp D, Alicia Nachtigal, Michael M Krausz, Itamar Itamar, Mika Shapira-Rootman
BACKGROUND: Four-dimensional parathyroid computed tomography (4DCT) is a relatively new parathyroid imaging technique that provides functional and highly detailed anatomic information about parathyroid tumors. OBJECTIVES: To assess the accuracy of 4DCT for the preoperative localization of parathyroid adenomas (PTAs) in patients with biochemically confirmed primary hyperparathyroidism (PHPT) and a history of failed surgery or unsuccessful localization using 99mTc-sestamibi scanning and ultrasonography...
April 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28467334/quality-control-on-radiochemical-purity-in-technetium-99m-radiopharmaceuticals-labelling-three-years-of-experience-on-2280-procedures
#9
Claudio Maioli, Giovanni Luciniani, Aldo Strinchini, Luca Tagliabue, Angelo Del Sole
OBJECTIVE: the purpose of this study was to offer an example of evaluations of the ISO9001 certified internal quality assurance (QA) system of 99mTc-radiopharmaceutical preparations and quality control in vivo use, using industrial kits and generators in order to identify possible sources of errors in the procedures labeling and quality control procedures. METHODS: The study was performed at a single institution over a period of three years (July 1st, 2011 - July 1st, 2014), and included a total of 2280 radiopharmaceutical preparations prepared by four different technologists...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28462644/evaluation-of-the-radiation-dose-exposure-and-associated-cancer-risks-in-patients-having-preoperative-parathyroid-localization
#10
S R Moosvi, S Smith, J Hathorn, T Groot-Wassink
OBJECTIVE The study aimed to evaluate the total effective and organ absorbed radiation doses associated with three- and four-phase parathyroid computed tomography (CT) and sestamibi scans used for the preoperative localisation of parathyroid adenomas in a cohort of patients with primary hyperparathyroidism at a single institution. We aimed to assess the risk of cancer incidence for the organs demonstrating the highest absorbed doses for the different imaging techniques, and more specifically determine the risk for our cohort of patients...
May 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28458875/a-rare-case-of-mediastinal-functioning-parathyroid-adenoma-removed-successfully-with-thoracoscopy
#11
Masashi Ishikawa, Shin-Ichi Sumitomo, Naoto Imamura, Tomoki Nishida, Katsutaka Mineura
We report here a rare case of primary hyperparathyroidism that was associated with an ectopic parathyroid adenoma located in the mediastinum. A 66-year-old woman suffering from primary hyperparathyroidism had been followed-up on an outpatient basis for over 10 years. She suffered from persistent urolithiasis and osteopenia due to hypercalcemia. After technetium-99-sestamibi (99mTc-MIBI) scintigraphy revealed an ectopic adenoma in the superior mediastinum, thoracoscopic resection of the tumor was performed. Subsequently, her serum parathyroid hormone (PTH) level decreased dramatically and her serum calcium concentration was restored to normal...
April 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28450657/parathyroid-adenoma-in-a-young-female-presenting-multiple-fractures-and-postoperative-hungry-bone-syndrome
#12
Hari Hendarto, Laurentius A Pramono, Dante S Harbuwono, Em Yunir, Imam Subekti
A young 18-year-old female patient with general bone pain and history of multiple fractures brought her to our medical attention. Laboratory work showed hypercalcemia and high parathyroid hormone levels in the blood. Radiograph imaging revealed severe scoliosis with multiple vertebrae fractures with decreased bone mineral density. Sestamibi showed parathyroid adenoma. This case emphasizes the importance of maintaining a primary hyperparathyroidism as a differential diagnosis when a young patient presents with a multiple pathologic fractures history...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28410289/initial-experience-with-real-time-hybrid-single-photon-emission-computed-tomography-computed-tomography-guided-percutaneous-transthoracic-needle-biopsy
#13
Qian Hua, Xiangyun Zhu, Lei Zhang, Yanjun Zhao, Ping Tang, Jianming Ni
The aim of this study was to explore a technique that uses real-time fusion image of single-photon emission computed tomography/computed tomography (SPECT/CT) to guide percutaneous transthoracic needle biopsy (PTNB) and test its feasibility and safety in patients. Twelve patients with intrathoracic lesions suspicious for malignancy underwent real-time 99m-technetium sestamibi SPECT/CT-guided PTNB. Chest SPECT/CT fusion images were used for biopsy planning and intraprocedure fusion of SPECT with guiding CT was used to adjust the puncture angle and direction...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28407050/infarct-size-left-ventricular-function-and-prognosis-in-women-compared-to-men-after-primary-percutaneous-coronary-intervention-in-st-segment-elevation-myocardial-infarction-results-from-an-individual-patient-level-pooled-analysis-of-10-randomized-trials
#14
Ioanna Kosmidou, Björn Redfors, Harry P Selker, Holger Thiele, Manesh R Patel, James E Udelson, E Magnus Ohman, Ingo Eitel, Christopher B Granger, Akiko Maehara, Ajay Kirtane, Philippe Généreux, Paul L Jenkins, Ori Ben-Yehuda, Gary S Mintz, Gregg W Stone
Aim: Studies have reported less favourable outcomes in women compared with men after primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). Whether sex-specific differences in the magnitude or prognostic impact of infarct size or post-infarction cardiac function explain this finding is unknown. Methods and results: We pooled patient-level data from 10 randomized primary PCI trials in which infarct size was measured within 1 month (median 4 days) by either cardiac magnetic resonance imaging or technetium-99m sestamibi single-photon emission computed tomography...
April 12, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28379356/decreased-glycolytic-metabolism-in-non-compaction-cardiomyopathy-by-18f-fluoro-2-deoxyglucose-positron-emission-tomography-new-insights-into-pathophysiological-mechanisms-and-clinical-implications
#15
Marcelo Dantas Tavares de Melo, Maria Clementina Pinto Giorgi, Antonildes Nascimento Assuncao, Roberto Nery Dantas, Jose de Arimateia Araujo Filho, Jose Rodrigues Parga Filho, Ana Luiza de Souza Bierrenbach, Camila Rocon de Lima, José Soares, José Claudio Meneguetti, Charles Mady, Ludhmila Abrahão Hajjar, Roberto Kalil Filho, Edimar Alcides Bocchi, Vera Maria Cury Salemi
Aims: The pathophysiological mechanisms of left ventricular non-compaction cardiomyopathy (LVNC) remain controversial. This study performed combined 18F-fluoro-2-deoxyglucose dynamic positron emission tomography (FDG-PET) and 99mTc-sestamibi single-photon emission computed tomography (SPECT) studies to evaluate myocardial glucose metabolism and perfusion in patients with LVNC and their clinical implications. Methods and results: Thirty patients (41 ± 12 years, 53% male) with LVNC, diagnosed by cardiovascular magnetic resonance (CMR) criteria, and eight age-matched healthy controls (42 ± 12 years, 50% male) were prospectively recruited to undergo FDG-PET with measurement of the myocardial glucose uptake rate (MGU) and SPECT to investigate perfusion-metabolism patterns...
March 30, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28374327/scintigraphic-findings-in-end-stage-liver-disease-on-tc-99m-sestamibi-spect-ct-myocardial-perfusion-imaging
#16
Tarun Jain, N T K Thanseer, Ashwani Sood, Madan Parmar, Anish Bhattacharya, Bhagwant Mittal
Technetium-99m sestamibi myocardial perfusion imaging is commonly employed non-invasive study for evaluation of coronary artery disease; however, incidental extracardiac scintigraphic findings observed may provide additional diagnostic information. The authors present the unusual scintigraphic findings in a case of decompensated liver disease with right hepatic hydrothorax, being planned for orthotopic liver transplant.
April 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28364324/primary-hyperparathyroidism-insights-from-the-indian-phpt-registry
#17
Sanjay Kumar Bhadada, Ashutosh Kumar Arya, Satinath Mukhopadhyay, Rajesh Khadgawat, Suja Sukumar, Sailesh Lodha, Deependra N Singh, Anjali Sathya, Priyanka Singh, Anil Bhansali
The presentation of primary hyperparathyroidism (PHPT) is variable throughout the world. The present study explored retrospective data submitted to the Indian PHPT registry ( http://www.indianphptregistry.com ) between July 2005 and June 2015 from 5 centres covering four different geographical regions. The clinical, biochemical, radiological and histopathological characteristics of PHPT patients across India were analysed for similarity and variability across the centres. A total of 464 subjects (137 men and 327 women) with histopathologically proven PHPT were analysed...
March 31, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28357787/visual-evaluation-and-differentiation-of-renal-oncocytomas-from-renal-cell-carcinomas-by-means-of-99m-tc-sestamibi-spect-ct
#18
Antonios Tzortzakakis, Ove Gustafsson, Mattias Karlsson, Linnea Ekström-Ehn, Rammin Ghaffarpour, Rimma Axelsson
BACKGROUND: Despite the progress in the quality of multiphasic CT and MRI scans, it is still difficult to fully characterize a solid kidney lesion. Approximately 10% of all solid renal tumours turn out to be oncocytomas. In actual clinical practice, this is verified only following unnecessary surgery or a renal biopsy/ablation. The objective of our pilot study examines whether (99m)Tc-sestamibi SPECT/CT can play a crucial role in the characterization of solid renal neoplasms and the differentiation of oncocytomas from renal cell carcinomas...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28342443/incidental-metastatic-mediastinal-atypical-carcinoid-in-a-patient-with-parathyroid-adenoma-a-case-report
#19
Zareen Kiran, Asma Ahmed, Owais Rashid, Saira Fatima, Faizan Malik, Saulat Fatimi, Mubassher Ikram
BACKGROUND: Atypical carcinoid arising from the mediastinal tissue is a rare neuroendocrine tumor and an association with parathyroid adenoma is very unusual. We report an unusual case of atypical carcinoid of mediastinum with metastasis in a patient presenting with parathyroid adenoma, which is the first case to be reported from Pakistan. CASE PRESENTATION: A 51-year-old Pakistani man was seen in postoperative intensive care after right parathyroidectomy and mediastinal mass resection for the management of postoperative hypocalcaemia...
March 26, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28330661/association-between-high-sensitivity-cardiac-troponin-levels-and-myocardial-ischemia-during-mental-stress-and-conventional-stress
#20
Muhammad Hammadah, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Malik Obideen, Naser Abdelhadi, Shuyang Fang, Ijeoma Ibeanu, Pratik Pimple, Heval Mohamed Kelli, Amit J Shah, Brad Pearce, Yan Sun, Ernest V Garcia, Michael Kutner, Qi Long, Laura Ward, J Douglas Bremner, Fabio Esteves, Paolo Raggi, David Sheps, Viola Vaccarino, Arshed A Quyyumi
OBJECTIVES: This study sought to investigate whether patients with mental stress-induced myocardial ischemia will have high resting and post-mental stress high-sensitivity cardiac troponin I (hs-cTnI). BACKGROUND: Hs-cTnI is a marker of myocardial necrosis, and its elevated levels are associated with adverse outcomes. Hs-cTnI levels may increase with exercise in patients with coronary artery disease. Mental stress-induced myocardial ischemia is also linked to adverse outcomes...
March 10, 2017: JACC. Cardiovascular Imaging
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