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https://www.readbyqxmd.com/read/29142342/prevalence-of-subclinical-peripheral-vascular-disease-in-obese-egyptian-patients
#1
Jehan Ahmed Younes, Nahla Dessoki El-Sayed, Ayman Ismail Kamel
Objective: To detect subclinical peripheral vascular disease in obese Egyptian patients and establish relations between obesity, metabolic risk factors, and PVD. Methods: This was a prospective case-control study including 100 obese patients (BMI >30) (G1). In addition, 100 age and sex matched non-obese healthy subjects as a control group (G2). Both groups were subjected to duplex ultrasound, Radionuclide muscle scan. Angiography was done for 17 patients. Results: The image pattern of 99mTc-MIBI muscles uptake was studied and perfusion reserve (PR%) was calculated in (G1) and (G2)...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29134314/surgery-for-primary-hyperparathyroidism-with-normal-non-suppressed-parathyroid-hormone-can-be-both-challenging-and-successful
#2
Lauren E Orr, Travis J McKenzie, Geoffrey B Thompson, David R Farley, Robert A Wermers, Melanie L Lyden
BACKGROUND: Criteria for diagnosing primary hyperparathyroidism (PHPT) include hypercalcemia in the presence of parathyroid hormone (PTH) levels that are either elevated (classic PHPT) or normal but non-suppressed. However, there is no standard definition of what constitutes normal non-suppressed levels, and data are lacking regarding the potential for surgical cure in these patients. METHODS: A retrospective review of patients undergoing parathyroidectomy for sporadic PHPT between 2012 and 2014 was performed...
November 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29129358/indocyanine-green-fluorescence-guided-parathyroidectomy-for-primary-hyperparathyroidism
#3
Jonathan C DeLong, Erin P Ward, Thinzar M Lwin, Kevin T Brumund, Kaitlyn J Kelly, Santiago Horgan, Michael Bouvet
BACKGROUND: Our aim was to evaluate the ease and utility of using indocyanine green fluorescence angiography for intraoperative localization of the parathyroid glands. METHODS: Indocyanine green fluorescence angiography was performed during 60 parathyroidectomies for primary hyperparathyroidism during a 22-month period. Indocyanine green was administered intravenously to guide operative navigation using a commercially available fluorescence imaging system. Video files were graded by 3 independent surgeons for strength of enhancement using an adapted numeric scoring system...
November 9, 2017: Surgery
https://www.readbyqxmd.com/read/29099412/dual-time-point-quantitative-spect-ct-parathyroid-imaging-using-a-single-computed-tomography-feasibility-and-operator-variability
#4
Simin Razavi, Blair Ziebarth, Ran Klein, Wanzhen Zeng
OBJECTIVES: Dual-phase parathyroid scan with Tc-sestamibi is a standardized imaging method for diagnosing parathyroid adenoma and hyperplasia. Conventional planar images using a gamma camera are performed routinely in early and delayed time points, followed by a single SPECT-CT. SPECT-CT on both early and delayed time points, although clinically useful, is not commonly performed to avoid extra radiation exposure from computed tomography (CT). This study explores the feasibility of co-registering early and delayed SPECT-CT from a single CT and evaluates the most effective combination of images for co-registration...
November 2, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29078878/machine-learning-to-identify-multigland-disease-in-primary-hyperparathyroidism
#5
Joseph R Imbus, Reese W Randle, Susan C Pitt, Rebecca S Sippel, David F Schneider
BACKGROUND: 20%-25% of patients with primary hyperparathyroidism will have multigland disease (MGD). Preoperatative imaging can be inaccurate or unnecessary in MGD. Identification of MGD could direct the need for imaging and inform operative approach. The purpose of this study is to use machine learning (ML) methods to predict MGD. METHODS: Retrospective review of a prospective database. The ML platform, Waikato Environment for Knowledge Analysis, was used, and we selected models for (1) overall accuracy and (2) preferential identification of MGD...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29076902/focal-pulmonary-uptake-on-99mtc-sestamibi-parathyroid-scintigraphy-due-to-iatrogenic-microembolism
#6
Ying Kou, Guohua Shen, Xiaohong Ou, Rui Huang, Anren Kuang
A middle-aged woman underwent Tc-sestamibi parathyroid scintigraphy because of parathyroid disease, and a focal pulmonary uptake of Tc-sestamibi was incidentally found on both planar and SPECT/CT images without corresponding pulmonary abnormality on the CT images. After 10 days, a subsequent parathyroid scintigraphy revealed no pulmonary accumulation. Therefore, the pulmonary intense Tc-sestamibi focus that once appeared in the first scan might be an artifact of iatrogenic microembolism from injection site.
October 26, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29063298/four-dimensional-computed-tomography-clinical-impact-for-patients-with-primary-hyperparathyroidism
#7
Yuan Tian, Sharman Tan Tanny, Paul Einsiedel, Meir Lichtenstein, Damien L Stella, Pramit M Phal, Julie A Miller
BACKGROUND: In recent years, four-dimensional computed tomography (4DCT) has emerged as a new localization study for primary hyperparathyroidism (pHPT). OBJECTIVE: We aimed to assess the added value of 4DCT in our institution in the first 4 years of use. METHODS: A retrospective cohort study was conducted from February 2004 to June 2015. Since 2011, patients over 50 years of age without concordant sestamibi-SPECT (SeS) and ultrasound (US) findings underwent 4DCT...
October 23, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29059950/preoperative-parathyroid-localization-using-joint-planar-imaging
#8
Richalannaphat Srikram, Pisit Jarumaneeroj, Tawatchai Chaiwatanarat, Yothin Rakvongthai
The conventional approach for preoperative parathyroid localization with the dual (99m)Tc-sestamibi ((99m)Tc-MIBI) and (99m)Tc-pertechnetate ((99m)TcO4(-) ) scintigraphy technique obtains the differential image by subtracting images from the two scans; the former depicts both the thyroid and parathyroid glands while the latter depicts the thyroid only. In this study, we developed a novel method based on Poisson noise modeling and maximum-likelihood estimation to generate the differential image in an iterative fashion using both planar images jointly...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054958/bone-and-muscular-viability-assessment-before-amputation-usefulness-of-bone-scan-and-99m-tc-sestamibi-dual-phase-scintigraphy
#9
Steve Durante, Maria Helena Perez, Anthony De Buys Roessingh, Ariane Boubaker
No abstract text is available yet for this article.
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29022783/current-predictive-models-do-not-accurately-differentiate-between-single-and-multi-gland-disease-in-primary-hyperparathyroidism-a-retrospective-cohort-study-of-two-endocrine-surgery-units
#10
O Edafe, E E Collins, C S Ubhi, S P Balasubramanian
Background Minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism is dependent upon accurate prediction of single-gland disease on the basis of preoperative imaging and biochemistry. The aims of this study were to validate currently available predictive models of single-gland disease in two UK cohorts and to determine if these models can facilitate MIP. Methods This is a retrospectively cohort study of 624 patients who underwent parathyroidectomy for primary hyperparathyroidism in two centres between July 2008 and December 2013...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28988020/management-of-mediastinal-parathyroid-adenoma-via-minimally-invasive-thoracoscopic-surgery-case-report
#11
Saulat Hasnain Fatimi, Hina Inam, Farida Karim Chagan, Usama Khalid Choudry
INTRODUCTION: The most common cause of chronic hypercalcemia is primary hyperparathyroidism (PHPT). However, owing to the diverse presentation of hypercalcemia, the diagnosis often goes unnoticed culminating as a continuum of recurrence of symptoms. Nephrolithiasis, decreased bone mineral density and peptic ulcer disease are the main clinical sequelae. Among the causes of PHPT 80% are caused by parathyroid adenomas (PA). However, only rarely, these adenomas are found ectopically. PRESENTATION OF CASE: We present the case of a 66-year-old female with a history of recurrent renal stones and peptic ulcer disease...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28987702/the-diagnostic-accuracy-of-neck-ultrasound-4d-computed-tomographyand-sestamibi-imaging-in-parathyroid-carcinoma
#12
Ioannis Christakis, Thinh Vu, Hubert H Chuang, Bryan Fellman, Angelica M Silva Figueroa, Michelle D Williams, Naifa L Busaidy, Nancy D Perrier
INTRODUCTION: Our aim was to investigate the accuracy of available imaging modalities for parathyroid carcinoma (PC) in our institution and to identify which imaging modality, or combination thereof, is optimal in preoperative determination of precise tumor location. METHODS: All operated PC patients in our institution between 2000 and 2015 that had at least one of the following in-house preoperative scans: neck ultrasonography (US), neck 4D-Computed Tomography (4DCT) and 99mTc Sestamibi SPECT/CT (MIBI)...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28986223/inflammatory-response-to-mental-stress-and-mental-stress-induced-myocardial-ischemia
#13
Muhammad Hammadah, Samaah Sullivan, Brad Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T O'Neal, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Heval Mohamed Kelli, Mohamad Mazen Ghafeer, Pratik Pimple, Pratik Sandesara, Amit J Shah, Kareem Mohammed Hosny, Laura Ward, Yi-An Ko, Yan V Sun, Lei Weng, Michael Kutner, J Douglas Bremner, David S Sheps, Fabio Esteves, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia. METHODS: Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor...
October 3, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28984813/dual-isotope-subtraction-spect-ct-in-parathyroid-localization
#14
Anna-May Woods, Alison A Bolster, Sai Han, Fat-Wui Poon, David Colville, John Shand, James B Neilly
OBJECTIVE: The aim of this study was to investigate the accuracy of locating parathyroid adenomas using dual-Isotope subtraction single-photon emission computed tomography-computed tomography (SPECT-CT) in comparison with clinical follow-up and pathology findings from surgery. PATIENTS AND METHODS: A retrospective cohort study of dual-isotope subtraction SPECT-CT was carried out on 224 consecutive patients who were diagnosed with primary hyperparathyroidism. All the patients were injected with 20 MBq of iodine-123-iodide, followed 20 min later by 900 MBq of technetium-99m-sestamibi...
December 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28976333/a-comparison-of-iterative-reconstruction-and-prone-imaging-in-reducing-the-inferior-wall-attenuation-in-tc-99m-sestamibi-myocardial-perfusion-spect
#15
Duygu Kuşlu, Emel Öztürk
OBJECTIVE: Prone positioning, iterative reconstruction (IR-OSEM) and electrocardiography (ECG) gating have been demonstrated to improve the specificity of myocardial perfusion SPECT (MPS) in the diagnosis of coronary artery disease. METHODS: The gated supine and prone MPS images of 45 patients were reconstructed with both IR-OSEM [supine (SIR) and prone (PIR)] FBPs [supine (SFBP), prone (PFBP)] for comparison. Perfusion, wall motion (WM) and wall thickening were also interpreted semi-quantitatively...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28971329/correlation-of-99m-tc-sestamibi-uptake-in-renal-masses-with-mitochondrial-content-and-multi-drug-resistance-pump-expression
#16
Steven P Rowe, Michael A Gorin, Lilja B Solnes, Mark W Ball, Ajuni Choudhary, Phillip M Pierorazio, Jonathan I Epstein, Mehrbod S Javadi, Mohamad E Allaf, Alex S Baras
BACKGROUND: (99m)Tc-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has recently been explored for the characterization of indeterminate renal masses. As judged by increased intra-tumoral radiotracer uptake, we have previously reported the excellent diagnostic performance characteristics of this test for identifying benign/indolent oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs). In this study, we investigated potential molecular mechanisms underlying the discriminatory ability of (99m)Tc-sestamibi SPECT/CT for renal masses...
October 2, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28963593/retropharyngeal-parathyroid-glands-important-differences
#17
James W Gallagher, Meghan L Kelley, Linwah Yip, Sally E Carty, Kelly L McCoy
INTRODUCTION: In primary hyperparathyroidism (PHPT), parathyroid ectopia is seen in up to 22% leading to more difficult surgery. We aimed to determine the rate and characteristics of retropharyngeal (RP) parathyroid glands. METHODS: A prospective database was queried for patients with sporadic PHPT who had surgery from 1997 to 2016. The data of RP patients were compared to those who had surgery for sporadic PHPT over the same time period with hyperfunctioning parathyroids in anatomically normal positions (N)...
September 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28902729/comparative-effectiveness-of-ultrasonography-99mtc-sestamibi-and-18f-fluorocholine-pet-ct-in-detecting-parathyroid-adenomas-in-patients-with-primary-hyperparathyroidism
#18
Ntk Thanseer, Sanjay Kumar Bhadada, Ashwani Sood, Bhagwant Rai Mittal, Arunanshu Behera, Arun Kumar Reddy Gorla, Renjith R Kalathoorakathu, Priyanka Singh, Divya Dahiya, Uma Nahar Saikia, Sudhaker D Rao
PURPOSE: Accurate preoperative localization of parathyroid lesion(s) is crucial for successful surgical management of primary hyperparathyroidism (PHPT). This study was conducted to compare the effectiveness of ultrasonography (USG) of the neck, Tc-sestamibi (MIBI) imaging with or without SPECT/CT, and F-fluorocholine (FCH) PET/CT imaging in the preoperative localization of parathyroid lesions in patients with PHPT. METHODS: Fifty-four consecutive patients with PHPT were included in this prospective study who underwent preoperative localization of the parathyroid lesion(s) using 3 diagnostic modalities followed by surgery...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28888222/primary-hyperparathyroidism-caused-by-enormous-unilateral-water-clear-cell-parathyroid-hyperplasia
#19
Georgios Boutzios, Helen Sarlanis, Anna Kolindou, Antigoni Velidaki, Theodore Karatzas
BACKGROUND: Parathyroid water-clear cell hyperplasia (WCCH) and water-clear cell adenoma (WCCA) are rare causes of primary hyperparathyroidism. The frequency of WCCH seems to be less than 1% of all primary hyperplasia. CASE PRESENTATION: We report a 53-year-old woman with a large unilateral water clear cell parathyroid hyperplasia associated with primary hyperparathyroidism and severe osteoporosis. Ultrasonography showed a 5.4 cm multilobulated hypoechoic well defined mass localized in the lower half of the left thyroid lobe...
September 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28885540/stress-only-myocardial-perfusion-scintigraphy-a-prospective-study-on-the-accuracy-and-observer-agreement-with-quantitative-coronary-angiography-as-the-gold-standard
#20
June A Ejlersen, Ole May, Jesper Mortensen, Gitte L Nielsen, Jeppe F Lauridsen, Johansen Allan
OBJECTIVE: Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS: A total of 109 patients with typical angina and no previous coronary artery disease underwent a 2-day stress (exercise)/rest, gated, and attenuation-corrected (AC), 99m-technetium-sestamibi perfusion study, followed by invasive coronary angiography...
November 2017: Nuclear Medicine Communications
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