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https://www.readbyqxmd.com/read/28807325/radioguided-surgery-in-primary-hyperparathyroidism-results-and-correlation-with-intraoperative-histopathologic-diagnosis
#1
Juan P Suárez, María L Domínguez, Francisco J de Santos, José M González, Nuria Fernández, Fidel J Enciso
INTRODUCTION AND OBJECTIVES: Radioguided surgery is a minimally invasive surgical technique for the treatment of primary hyperparathyroidism. The goals of our study were to evaluate the rate of success and compare the results with intraoperative histological analysis. METHODS: We retrospectively studied 84 patients with primary parathyroidism who had undergone radioguided surgery. All the patients had a positive parathyroid scintigraphy prior to surgery. An intravenous injection of Tc-99m sestamibi was administered before surgery, and radioguided location of the pathologic parathyroid tissue was performed using an intraoperative gamma probe, applying the "20% rule"...
August 11, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28775107/a-garden-of-parathyroid-adenomas
#2
Zeyad T Sahli, Farah Karipineni, Martha A Zeiger
Despite improvements in parathyroidectomy success rates, patients with persistent primary hyperparathyroidism (PHPT) after initial surgery continue to challenge clinicians. Some of the challenges are due to ectopic parathyroid adenomas, including thymic, intrathyroidal, carotid sheath and mediastinal glands, and others are because of supernumerary glands. While uncommon in PHPT, multigland disease is also an important consideration in patients requiring reoperative surgery for persistent disease. For this reason, localisation studies including sestamibi, ultrasound, CT scan and venous sampling for abnormal glands may be an essential component of the preoperative workup...
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28746021/use-of-a-technetium99m-sestamibi-scan-to-detect-ipsilateral-double-adenoma-in-a-patient-with-primary-hyperparathyroidism-a-case-report
#3
Joseph Gabriel Gabriel, Alejandro Contreras, Andrew Rosenthal
INTRODUCTION: Patients with primary hyperparathyroidism generally have a single parathyroid adenoma that causes excessive excretion of parathyroid hormone. For about 2% to 15% of these patients, a double adenoma is present that involves one lesion on each side of the neck. CASE PRESENTATION: We describe a case of double parathyroid adenoma causing asymptomatic hypercalcemia. A presurgical technetium99m (Tc99m) sestamibi scan suggested an ipsilateral double adenoma in the left thyroid lobe...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28741786/ectopic-parathyroid-adenoma-in-the-pyriform-sinus
#4
Jonathan Kim, Maricel Cubangbang, Lacey Adkins, Stanley Chia, Timothy R DeKlotz, Lisa Boyle, Bruce Davidson
BACKGROUND: Ectopic parathyroid glands may complicate the surgical approach to primary hyperparathyroidism. We describe a rare ectopic parathyroid location, the pyriform sinus. METHODS: Three patients, 2 after prior unsuccessful parathyroid exploration, were found to have ectopic parathyroid adenomas in the pyriform sinus. Two cases were identified by 4D-CT of the neck. The other was localized by a technetium 99m sestamibi single photon emission CT (SPECT). In each case, office endoscopy confirmed the lesions...
July 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28732535/case-report-rare-skeletal-manifestations-in-a-child-with-primary-hyperparathyroidism
#5
Maulee Hiromi Arambewela, Kamani Danushka Liyanarachchi, Noel P Somasundaram, Aruna S Pallewatte, Gamini L Punchihewa
BACKGROUND: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. CASE PRESENTATION: A 12 year old Sri Lankan girl presented with progressive difficulty in walking since 1 year. On examination she had bilateral genu valgum...
July 21, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28728876/is-technetium-99m-sestamibi-imaging-able-to-predict-pathologic-nonresponse-to-neoadjuvant-chemotherapy-in-breast-cancer-a-meta-analysis-evaluating-current-use-and-shortcomings
#6
Angela Collarino, Elizabeth J de Koster, Renato A Valdés Olmos, Lioe-Fee de Geus-Oei, Lenka M Pereira Arias-Bouda
BACKGROUND: Interest in technetium-99m ((99m)Tc)-sestamibi imaging for neoadjuvant chemotherapy (NAC) response monitoring in locally advanced breast cancer (LABC) is increasing but remains matter of discussion. The present study conducted a meta-analysis of the diagnostic performance of (99m)Tc-sestamibi to predict pathologic nonresponse to NAC for primary LABC. MATERIALS AND METHODS: A systematic data search was performed. Studies with a minimum of 10 LABC patients that had evaluated (99m)Tc-sestamibi imaging for NAC nonresponse using conventional planar scintimammography, breast-specific γ-imaging, and/or single photon emission computed tomography/computed tomography (SPECT/CT) were included...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28705526/utility-of-single-phase-computed-tomography-in-identifying-parathyroid-adenomas-a-feasibility-study
#7
Ethan Silver, Nader Sadeghi, Stanley Knoll, M Reza Taheri
OBJECTIVE: We tested the hypothesis that a single-phase neck computed tomography (CT) is not inferior to multiphase neck CT (MPNCT), ultrasound, or nuclear medicine sestamibi scan in identifying parathyroid adenomas (PAs). METHODS: A total of 29 patients who had an MPNCT for the evaluation of a PA were identified; 11 patients met the inclusion criteria. During the 30-second arterial phase CT (APNCT), a normalized Hounsfield unit of suspected PA was compared to Hounsfield unit of a normal-appearing level I and a level II lymph node...
May 17, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28683236/the-results-of-parathyroid-hormone-assay-in-parathyroid-aspirates-in-preoperative-localization-of-parathyroid-adenomas-for-focused-parathyroidectomy-in-patients-with-negative-or-suspicious-technet%C3%A4-um-99-msestam%C3%A4-b%C3%A4-scans
#8
Aysenur Ozderya, Sule Temizkan, Kenan Cetin, Sule Ozugur, Aylin Ege Gul, Kadriye Aydin
OBJECTIVE: This study aims to evaluate the results of parathyroid hormone (PTH) assay in parathyroid aspirates to determine uniglandular disease by an endocrinologist-performed ultrasound in patients with discordant or negative technetium ((99m)Tc) sestamibi scans and to evaluate whether this pocedure increases the number of focused parathyroidectomy (FP). METHODS: We analyzed the data of 65 patients who underwent an endocrinologist-performed ultrasound (US) guided parathyroid fine needle aspiration (FNA) with PTH wash-out, retrospectively...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28680214/ectopic-parathyroid-incidentaloma-on-tc99m-sestamibi-myocardial-perfusion-imaging
#9
Rola Aatif Hasan Hussain, Ammar Mohammed Saeed Ali, K Manivannan, S K Chirala
Parathyroid incidentalomas are generally discovered during thyroid surgery.([1]) In the present case, the ectopic parathyroid adenoma was discovered as an incidentaloma in a clinical setting, during the course of clinical evaluation of atypical chest pain by gastroenterology and cardiology.
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28680200/radio-guided-minimally-invasive-parathyroidectomy-a-descriptive-report-of-the-experience-from-tertiary-center-in-bangalore
#10
Bhushan Vidya, Shubhra Chauhan, Naveen Hedne Chandrasekhar, H V Sunil, Vijay Pillai, Vivek Shetty, R L Vijayaraghavan, Moni Abraham Kuriakose, Subramanian Kannan
OVERVIEW: Minimally invasive parathyroidectomy (MIP) is an accepted surgical procedure for parathyroid adenomas. In the patients with parathyroid adenoma localized by dual phase (99m)Tc-Sestamibi scan, a focused approach utilizing the gamma probe intra-operatively helps in ensuring complete resection and avoiding exploration of the other parathyroid glands. OBJECTIVE: The aim of the study was to evaluate the performance of radio-guided MIP for parathyroid adenomas detected by dual phase (99m)Tc-MIBI preoperatively, without intra-operative parathyroid hormone (ioPTH) monitoring for patients who had evidence of single-gland disease...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28680199/diagnostic-accuracy-of-stress-myocardial-perfusion-imaging-in-indian-diabetic-patients-a-single-centre-experience
#11
Deepa Kumar, Ravinder Singh Sethi, Sandeep Bansal, Padma A Namgyal, Aditi Khurana Sehgal, Tajamul Syed Malik
Diabetics have around 2-4 times increased risk of coronary artery disease(CAD) and it is the most important cause of mortality in these patients. This study was carried out to compare the sensitivity, specificity and accuracy of MPI-SPECT among diabetics and non-diabetics in the Indian population. MATERIAL AND METHODS: This retrospective study included 261 patients; 213 males and 48 females, with 75 diabetic and 186 non-diabetic patients. Only type II diabetics and non-diabetic patients were included in the study...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28670179/evaluation-of-diastolic-function-in-patients-with-normal-perfusion-and-type-2-diabetes-mellitus-with-gated-single-photon-emission-computed-tomography
#12
Ayse Nurdan Korkmaz, Billur Caliskan, Fatma Erdem
Early identification of diastolic dysfunction of patients with diabetes is important in preventing cardiac events. In this study, we aimed to show that both myocardial perfusion and diastolic function parameters can be evaluated in diabetic patients with possible silent cardiac symptoms using gated single-photon emission computed tomography (G-SPECT). We examined eighty patients: Forty with and forty without diabetes. The patients were compared in terms of systolic and diastolic parameters obtained using G-SPECT...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28664482/prognostic-value-of-a-faster-low-radiation-myocardial-perfusion-spect-protocol-in-a-czt-camera
#13
Ronaldo S L Lima, Thaís R Peclat, Ana Carolina A H Souza, Aline M K Nakamoto, Felipe M Neves, Victor F Souza, Letícia B Glerian, Andrea De Lorenzo
To determine the prognostic value of a new, ultrafast, low dose myocardial perfusion SPECT (MPS) protocol in a cadmium-zinc telluride (CZT) camera. CZT cameras have introduced significant progress in MPS imaging, offering high-quality images despite lower doses and scan time. Yet, it is unknown if, with such protocol changes, the prognostic value of MPS is preserved. Patients had a 1-day 99 m-Tc-sestamibi protocol, starting with the rest (185-222 MBq) followed by stress (666-740 MBq). Acquisition times were 6 and 3 min, respectively...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28658791/ectopic-parathyroid-adenoma-presenting-as-a-mediastinal-mass
#14
Aneesha Vaidya, Mangala Gouri, H M Sudha, Vijaya Mysorekar, Avinash Balekudura
A parathyroid adenoma present in an ectopic site, in the anterior mediastinum, is a rare cause of persistent hyperparathyroidism. Though its occurrence in the mediastinum is unusual, existence has been noted in literature for more than a century. We describe a case of a 35-year-old male presenting with complaints of pain abdomen, clinically diagnosed as acute necrotizing pancreatitis, with raised serum calcium. Patient received symptomatic treatment for the pancreatitis which subsided. However, high levels of serum calcium persisted...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28621914/distinguishing-parathyroid-and-thyroid-lesions-on-ultrasound-guided-fine-needle-aspiration-a-correlation-of-clinical-data-ancillary-studies-and-molecular-analysis
#15
Margaret Cho, Thaira Oweity, Tamar C Brandler, Karen Fried, Pascale Levine
BACKGROUND: Differentiating parathyroid and thyroid lesions can be challenging because of considerable morphologic overlap and anatomic proximity. Therefore, the authors sought to identify characteristic morphologic patterns and useful adjunct tests to distinguish these 2 entities. METHODS: A search was conducted in the study institution database for clinically indeterminate thyroid nodules from 2000 through 2016 with an emphasis on confirmed parathyroid nodules...
June 16, 2017: Cancer
https://www.readbyqxmd.com/read/28579328/the-evaluations-of-99m-tc-cyclopentadienyl-tricarbonyl-triphenyl-phosphonium-cation-for-multidrug-resistance
#16
Shuting Chen, Ying Zhang, Xiaoyan Li, Hongmei Jia, Jie Lu
A triphenylphosphonium cation, [(99m)Tc]Technetium cyclopentadienyltricarbonyl-6-hexanoyl-triphenylphosphonium cation ([(99m)Tc]3) was prepared to target multidrug resistance (MDR). The radiotracer was evaluated in the MDR-negative MCF-7 and MDR-positive MCF-7/ADR cell lines in vitro, as well as animal models in vivo. [(99m)Tc]3 was proofed to be a substrate of P-glycoprotein and multidrug resistant protein 1, and showed a higher accumulation in the MDR-negative MCF-7 cells compared to (99m)Tc-sestamibi in vitro...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28571621/hemodynamic-catecholamine-vasomotor-and-vascular-responses-determinants-of-myocardial-ischemia-during-mental-stress
#17
Muhammad Hammadah, Ayman Alkhoder, Ibhar Al Mheid, Kobina Wilmot, Nino Isakadze, Naser Abdulhadi, Danielle Chou, Malik Obideen, Wesley T O'Neal, Samaah Sullivan, Ayman Samman Tahhan, Heval Mohamed Kelli, Ronnie Ramadan, Pratik Pimple, Pratik Sandesara, Amit J Shah, Laura Ward, Yi-An Ko, Yan Sun, Irina Uphoff, Brad Pearce, Ernest V Garcia, Michael Kutner, J Douglas Bremner, Fabio Esteves, David S Sheps, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
AIMS: Mental stress-induced myocardial ischemia (MSIMI) in patients with coronary artery disease (CAD) is associated with adverse cardiovascular outcomes. We aim to assess hemodynamic, neuro-hormonal, endothelial, vasomotor and vascular predictors of MSIMI. METHODS AND RESULTS: We subjected 660 patients with stable CAD to 99mTc sestamibi myocardial perfusion imaging at rest, with mental (speech task) and with conventional (exercise/pharmacological) stress. Endothelium-dependent flow-mediated dilation (FMD), microvascular reactivity [reactive hyperemia index (RHI)] and arterial stiffness [pulse wave velocity (PWV)] were measured at rest and 30-min after mental stress...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28554885/osteolytic-lesions-osteitis-fibrosa-cystica-in-the-setting-of-severe-primary-hyperparathyroidism
#18
Lee Jervis, Matthew James, Warwick Howe, Stephen Richards
A 58-year-old female patient presented with several weeks history of significant bilateral knee pain. Initial knee radiographs demonstrated lucencies of the bony cortex while extensive osteolytic lesions on a routine chest radiograph were suggestive of multiple myeloma or bony metastases. Biochemical investigation revealed primary hyperparathyroidism with renal insufficiency. A parathyroid adenoma was demonstrated on a neck ultrasound and sestamibi scan and subsequently confirmed by histology. We illustrate a case of primary hyperparathyroidism with osteitis fibrosa cystica and brown tumours which were initially mistaken for malignant disease...
May 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28553182/ultrastructure-of-hyperfunctioning-parathyroid-glands-does-it-explain-various-patterns-of-99m-tc-sestamibi-uptake
#19
Abdelhamid H Elgazzar, Jehoran T Anim, Shorouk F Dannoon, Medhat M Farghaly
The aim of this study was to correlate the uptake of (99m)Tc-methoxy-isobutyl-isonitrile (MIBI) with ultra-structural features of parathyroid adenomas. Twenty patients with proven primary hyperparathyroidism were evaluated prospectively. Preoperative double-phase (99m)Tc-MIBI scintigraphy was performed in all patients and the degree of tracer uptake by the parathyroid lesions was assessed visually and semi-quantitatively. The excised glands were examined histologically and ultrastructurally, and their features were correlated with the degree of the radiotracer uptake...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28546708/unilateral-exploration-for-parathyroid-adenoma
#20
Maddibande Ramachar Sreevathsa, Khyati Melanta
Between January 2012 to 2016, 20 patients with primary hyperparathyroidism underwent surgical exploration for presumed diagnosis of parathyroid adenoma. Nineteen patients underwent ultrasonography of neck and USG was found to be accurate in localizing the adenoma in 84.2%. Seventeen patients underwent sestamibi isotope scanning and imaging correlated with operative findings in 94.1%. Combined accuracy of ulrasound and sestamibi scan which was done in 17 patients was 95%. Seventeen patients underwent unilateral exploration and there was resolution of disease in 94...
June 2017: Indian Journal of Surgical Oncology
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