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https://www.readbyqxmd.com/read/29341944/nuclear-medicine-methods-for-evaluation-of-abnormal-parathyroid-glands-in-patients-with-primary-and-secondary-hyperparathyroidism
#1
Albena D Botushanova, Nikolay P Botushanov, Marianna P Yaneva
Considered rare disease in the past, primary hyperparathyroidism (PHPT) has dramatically increased in incidence over the past thirty years with the introduction of routine calcium measurements; it is now approximately 42 per 100 000 persons. By far, the most common lesion found in patients with PHPT is the solitary parathyroid adenoma, occurring in 85%-90% of patients, while in the rest 10%- 15% primary hyperplasia of the parathyroid glands is present. Currently, the most widely used surgical approach is minimally invasive parathyroidectomy which is associated with less post-surgery complications and shorter operation time...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29340158/follicular-thyroid-cancer-avid-on-c-11-methionine-pet-ct
#2
Mads Ryø Jochumsen, Peter Iversen, Anne Kirstine Arveschoug
A case of follicular thyroid cancer with intense focal Methionine uptake on 11C-Methionine PET/CT is reported here. The use of 11C-Methionine PET in differentiated thyroid cancer is currently being investigated as a surrogate tracer compared to the more widely used 18F-FDG PET. This case illustrates the potential incremental value of this modality, not only in the localizing of parathyroid adenoma, but also indicating that 11C-Methionine PET might have a potential of increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29339573/-sup-18-sup-f-choline-pet-ct-for-parathyroid-scintigraphy-significantly-lower-radiation-exposure-of-patients-in-comparison-to-conventional-nuclear-medicine-imaging-approaches
#3
Sebastijan Rep, Marko Hocevar, Janja Vaupotič, Urban Zdesar, Katja Zaletel, Luka Lezaic
Parathyroid subtraction scintigraphy is the most commonly used imaging method for localization of hyperfunctioning parathyroid glands (HPG) in primary hyperparathyroidism, a common endocrine disorder. Hybrid (SPECT/CT) imaging with 99mTc-sestaMIBI (MIBI) at an early and delayed phase (dual-phase imaging) may be the most accurate conventional imaging approach, but includes additional radiation exposure due to added CT imaging. Recently, 18F-choline (FCH) PET/CT was introduced for HPG imaging, which can also be performed using the dual-phase approach...
January 17, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29319547/the-role-of-molecular-imaging-in-the-characterization-of-renal-masses
#4
Alexa R Meyer, Mohamad E Allaf, Steven P Rowe, Michael A Gorin
PURPOSE OF REVIEW: To explore the role of molecular imaging in the characterization of renal masses. RECENT FINDINGS: Incidentally detected renal masses exhibit variable malignant potential related to their underlying histology. Patients presenting with a renal mass should undergo individual risk stratification including characterization of their tumor histology. At the present time, anatomical imaging techniques are unable to reliably distinguish between the various renal tumor subtypes...
January 11, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29319141/the-use-of-67ga-scintigraphy-in-patients-with-sarcoidosis
#5
Ewa Malinowska, Anna Doboszyńska, Anna Śliwińska, John R Buscombe, Grzegorz Kulesza, Beata Moczulska, Jarosław B Ćwikła
Sarcoidosis is a systemic disease of unknown aetiology characterised by the formation of noncaseating granulomas in various organs and tissues. The various imaging modalities that are useful in the investigation of lesions, staging and establishing indications for treatment include: conventional radiography, CT, MRI, and scintigraphy with 67Ga, 201Tl, 99mTc sestamibi, and somatostatin receptor scintigraphy (SRS) as well as 18F-FDG-PET/CT. This paper discusses the most commonly used of the scintigraphic technique, gallium (67Ga) citrate) and its role in the evaluation and monitoring of patients with sarcoidosis...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29319134/diagnostic-accuracy-of-planar-spect-and-spect-ct-parathyroid-scintigraphy-protocols-in-patients-with-hyperparathyroidism
#6
Yutapong Raruenrom, Daris Theerakulpisut, Nantaporn Wongsurawat, Charoonsak Somboonporn
BACKGROUND: Several parathyroid scintigraphy protocols have been used for preoperative localization of hyperfunctioning parathyroid glands in patients with hyperparathyroidism. The aim of this study is to compare the diagnostic accuracy of various parathyroid scintigraphy protocols. MATERIAL AND METHODS: A retrospective diagnostic accuracy study with histopathology as the reference standard was done. Five imaging protocols were investigated including planar dual tracer Tc-99m pertechnetate/Tc-99m sestamibi (DT), planar dual phase Tc-99m sestamibi (DP), and combined dual tracer dual phase (DTDP) protocols, as well as add-on single photon emission computed tomography (SPECT), and single photon emission computed tomography/computed tomography (SPECT/CT)...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29317040/molecular-breast-imaging-a-comprehensive-review
#7
Ashley I Huppe, Anita K Mehta, Rachel F Brem
Molecular breast imaging (MBI), also called breast-specific gamma imaging (BSGI), has been an integral component of our breast imaging practice for over a decade. Unlike mammography and ultrasound that are based on anatomy, MBI is a physiologic approach to breast cancer detection. MBI detects additional foci of occult breast cancer in 9.0% of women with newly diagnosed breast cancer, has a high sensitivity for detecting high-risk lesions, and detects 98% of invasive breast cancer and 91.0% of ductal carcinoma in situ...
February 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29310821/sestamibi-spect-ct-versus-spect-only-for-preoperative-localization-in-primary-hyperparathyroidism-a-single-institution-8-year-analysis
#8
Kelly L McCoy, Anish G Ghodadra, Trilochan G Hiremath, Angela Albarano, Judith M Joyce, Linwah Yip, Sally E Carty, Ashok Muthukrishnan
BACKGROUND: Primary hyperparathyroidism is caused by single gland disease in 85% of cases and by multiglandular disease in 15%. Our aim was to discover if the addition of computed tomography acquisition/fusion on a hybrid scanner to traditional dual-phase single-photon emission tomography improves localization accuracy. METHODS: A prospective database was queried for the perioperative data of patients with sporadic primary hyperparathyroidism who had initial exploration from 2006-2014 with ≥6 month follow-up to define anatomy...
January 5, 2018: Surgery
https://www.readbyqxmd.com/read/29300866/diagnostic-utility-of-molecular-and-imaging-biomarkers-in-cytological-indeterminate-thyroid-nodules
#9
Elizabeth J de Koster, Lioe-Fee de Geus-Oei, Olaf M Dekkers, Ilse van Engen-van Grunsven, Jaap Hamming, Eleonora P M Corssmit, Hans Morreau, Abbey Schepers, Jan Smit, Wim J G Oyen, Dennis Vriens
Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As approximately 25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a pre-operative clinical setting, including considerations regarding cost-effectiveness, availability, and feasibility of combining techniques...
January 2, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29298216/the-utility-of-myocardial-perfusion-imaging-before-renal-transplantation-a-retrospective-analysis
#10
Paul D Callan, Sunil Bhandari, Andrew L Clark, David Eadington, Emmanouil Papadopoulos, Ann C Tweddel
BACKGROUND: Renal transplantation (RT) reduces morbidity and mortality in patients with end-stage renal failure. Myocardial perfusion imaging provides prognostic information in patients with renal failure, but its role before transplantation remains unclear. We performed a retrospective review assessing the prognostic value of technetium-99m sestamibi myocardial perfusion imaging at a tertiary UK centre. PATIENTS AND METHODS: We included scans performed between 2005 and 2012...
January 2, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29281866/comparative-diagnostic-performance-of-ultrasonography-and-99mtc-sestamibi-scintigraphy-for-parathyroid-adenoma-in-primary-hyperparathyroidism-systematic-review-and-meta-analysis
#11
Reza Nafisi Moghadam, Amir Pasha Amlelshahbaz, Nasim Namiranian, Mohammad Sobhan-Ardekani, Mahmood Emami-Meybodi, Ali Dehghan, Masoud Rahmanian, Seid Kazem Razavi-Ratki
Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. The search strategy was according PICO characteristics...
December 28, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29275380/double-hit-a-unique-case-of-resistant-hypertension
#12
Kristen Elizabeth DeCarlo, Nidhi Agrawal
A middle-aged woman with obesity, hyperlipidaemia and diet-controlled diabetes was referred for resistant hypertension. Her blood pressure (BP) was uncontrolled on five medications, including a diuretic. Physical exam revealed a systolic ejection murmur, and ECHO demonstrated moderate hypertrophy. Laboratory examination revealed elevated aldosterone level (20.7 ng/dL) and elevated aldosterone:renin ratio (41.4 (ng/dL)/(ng/mL/h)), meeting criteria for primary aldosteronism (PA), and confirmed by saline infusion testing...
December 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29261636/prognostic-value-of-99mtc-sestamibi-parathyroid-scintigraphy-in-predicting-future-surgical-eligibility-in-patients-with-asymptomatic-primary-hyperparathyroidism
#13
Zhaoting Cheng, Sijuan Zou, Dan Peng, Guopeng Zhang, Xiaohua Zhu
PURPOSE: Patients with asymptomatic primary hyperparathyroidism might have a positive Tc-sestamibi parathyroid but do not meet criteria for surgical resection when the disease is diagnosed. However, many of these asymptomatic patients will become symptomatic or meet criteria for surgery later on. The aim of this study was to determine whether a positive sestamibi scan can precede future surgical eligibility in these patients. METHODS: This retrospective study reviewed the records of 94 asymptomatic patients who had hyperparathyroidism and underwent Tc-sestamibi study with SPECT/CT imaging...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29261624/hyperparathyroidism-caused-by-coexisting-parathyroid-hyperplasia-and-ectopic-parathyroid-adenomas
#14
Peng Xie, Jianmin Huang
Tc sestamibi parathyroid scan was performed in a 35-year-old man with chronic renal failure to evaluate the cause of increased serum parathyroid hormone. Both early and delayed images showed intense activity overlapping the left upper pole of the thyroid, which was proven to be nodular parathyroid hyperplasia after parathyroidectomy. However, the levels of serum parathyroid hormone remained elevated postsurgically. A repeat sestamibi study revealed abnormal activity in the left upper mediastinum, which could also be subtly seen on initial sestamibi study...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29241464/-diagnostic-approach-and-treatment-of-primary-hyperparathyroidism
#15
W Y van der Plas, M E Noltes, A W M A Schaeffers, A H Brouwers, A N A van der Horst-Schrivers, S Kruijff
- Primary hyperparathyroidism (PHPT) is characterised by elevated serum calcium levels due to elevated levels, or insufficient suppression, of parathyroid hormone (PTH).- The incidence of PHPT has increased in recent years. This is mainly the result of more frequently performed routine measurements of serum calcium, e.g. as part of postmenopausal screening.- The classically described features of PHPT - bones and stones - are not always observed and most patients are asymptomatic.- Diagnosis of PHPT is only established by biochemical testing, not by imaging...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29237954/assessment-of-the-scatter-correction-procedures-in-single-photon-emission-computed-tomography-imaging-using-simulation-and-clinical-study
#16
Mehravar Rafati, Hemmatollah Rouhani, Ahmad Bitarafan-Rajabi, Mahsa Noori-Asl, Bagher Farhood, Hadi Taleshi Ahangari
BACKGROUND: Compton-scattered photons transfer incorrect spatial information. These photons are detected in used photo-peak energy window. In this study, three scatter correction procedures including dual-energy window (DEW), three energy window (TEW), and new approach were evaluated, and then the best procedure based on simulation and clinical conditions introduced. MATERIALS AND METHODS: In this study, simulation projections and three-dimensional nonuniform rational B-spline-based Cardiac-Torso phantoms were produced by GEANT4 application for emission tomography simulation code...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29214562/use-of-quantitative-spect-ct-reconstruction-in-99mtc-sestamibi-imaging-of-patients-with-renal-masses
#17
Krystyna M Jones, Lilja B Solnes, Steven P Rowe, Michael A Gorin, Sara Sheikhbahaei, George Fung, Eric C Frey, Mohamad E Allaf, Yong Du, Mehrbod S Javadi
OBJECTIVE: Technetium-99m (99mTc)-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has previously been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs) apart from other malignant renal tumor histologies, with oncocytomas/HOCTs showing high uptake and renal cell carcinoma (RCC) showing low uptake based on uptake ratios from non-quantitative single-photon emission computed tomography (SPECT) reconstructions...
December 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29212258/diagnostic-accuracy-of-99mtc-tc-sestamibi-in-the-assessment-of-thyroid-nodules
#18
Anna Yordanova, Soha Mahjoob, Philipp Lingohr, Jörg Kalff, Andreas Türler, Holger Palmedo, Hans-Jürgen Biersack, Glen Kristiansen, Jamshid Farahati, Markus Essler, Hojjat Ahmadzadehfar
[99mTc]Tc-Sestamibi (MIBI) is an increasingly used tool for evaluation of thyroid nodules. However, there is a lack of evidence about the accuracy of this method in the European population. The aim of this study was to assess the utility of MIBI for the differentiation of thyroid nodules in a large cohort. 161 patients underwent MIBI, followed by a thyroidectomy. We used a dual phase MIBI protocol. Interpretation of the images included a scoring system from 0 (absent) to 3 (increased); this was to provide a scale for the uptake of the thyroid nodule in comparison to the paranodular tissue...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29189860/-false-negative-spect-parathyroid-scintigraphy-with-sestamibi-in-patients-with-primary-hyperparathyroidism
#19
Gabriela Paillahueque, Teresa Massardo, Marcela Barberán, Gerson Ocares, Iván Gallegos, Luis Toro, A Verónica Araya
BACKGROUND: 99mTc-sestamibi parathyroid SPECT scintigraphy is a useful tool in the pre-operative study of hyperparathyroidism. False negatives (FN) have been reported in 5.7-14% of the examinations. AIM: To characterize 99mTc-sestamibi FN in cases referred for primary hyperparathyroidism (PHP) to a university hospital. MATERIAL AND METHODS: Descriptive retrospective analysis. We included patients with PHP, studied with SPECT scintigraphy, operated at our center between 2008 and 2015...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29181196/99mtc-sestamibi-123i-subtraction-spect-ct-in-parathyroid-scintigraphy-is-additional-pinhole-imaging-useful
#20
Virpi Tunninen, Pekka Varjo, Tomi Kauppinen, Anu Holm, Hannu Eskola, Marko Seppänen
Objectives: This retrospective study evaluated whether the use of additional anterior 99mTc-sestamibi/123I pinhole imaging improves the outcome of 99mTc-sestamibi/123I subtraction SPECT/CT in parathyroid scintigraphy (PS). Materials and Methods: PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study (n = 94)...
2017: International Journal of Molecular Imaging
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