Carmen Bobeica, Elena Niculet, Carmina Liana Musat, Lina Iancu, Mihaela Craescu, Andreea Mioara Luca, Bogdan Ioan Stefanescu, Emma Gheorghe, Mihaela Debita, Claudiu-Ionut Vasile, Gabriela Balan, Camelia Busila, Alin Laurentiu Tatu
PURPOSE: Systemic sclerosis (SSc) is a relatively rare collagenosis manifested as microvasculopathy, excessive cutaneous and visceral fibrosis in a background of autoimmune alteration. Autoimmune vasculopathy in SSc occurs early and begins with endothelial cell activation followed by blood vessel intimal proliferation in a context of defective angiogenesis. The alteration of peripheral micro and macrocirculation in SSc is evident through vascular lesions, such as Raynaud's phenomenon, telangiectasias, acrocyanosis, digital ulcers, gangrene, peripheral pulse deficiency...
2024: Clinical, Cosmetic and Investigational Dermatology