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Jacqueline A Pettersen, Julia Keith, Fuqiang Gao, J David Spence, Sandra E Black
OBJECTIVE: To underline the importance of blood pressure regulation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to describe changes that occur in the veins in this condition, specifically venous collagenosis associated with leukoaraiosis. METHODS: Case report with neuroimaging and pathologic data. RESULTS: A 61-year-old man with genetically confirmed CADASIL was initially lucid following a motor vehicle accident but subsequently became hypotensive (60/40 mm Hg) due to an open femur fracture and required intubation...
February 15, 2017: Neurology
Maria Cristina Beznă, Doina Cârstea, Marinela Beznă, Octavian Istrătoaie, Ionela Cristina Deliu, Petru Răzvan Melinte
Observation of major pathological alterations in a young person involves etiological and clinical justifications, in order to properly assess, treat and control these conditions. The aim of this paper is to present severe, acute pathological lesions, installed in a young person, secondary to hypodiastolic heart failure, due to persistent supraventricular tachyarrhythmia, triggered by a post-traumatic external stimulus, with complete remission post-electrical conversion. Pathological and clinical modification are revealed, in a young person, shortly after a minor thoracic trauma, in the absence of traumatic injury but with high-frequency palpitations onset and progressive installation of vascular, visceral and interstitial stasis modifications, as well as of vascular and tissular hypoperfusion with reactive vasoconstriction...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
C Wächter, B Markus, B Schieffer
Because of the life-threatening character and a high prevalence in emergency rooms, cardiac causes are important differential diagnoses of acute chest pain with the need for rapid clarification. In this context the working diagnosis "acute coronary syndrome" (ACS) plays a major role. In a synopsis of the clinical presentation, medical history, electrocardiogram and analysis of cardiac biomarkers, ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina pectoris can be specified as entities of ACS...
January 2017: Der Internist
Takaharu Ikeda, Naoya Mikita, Fukumi Furukawa, Yoshifumi Iwahashi
A 55-year-old man with rheumatoid arthritis presented hyperkeratotic erythematous papules with crusts or blisters on his limbs and buttocks. A histological study showed acquired reactive perforating collagenosis. Soon, skin lesions changed to umbilicated lesions with black necrosis, and the scar from his skin biopsy ulcerated with induration due to rheumatoid vasculitis. Systemic corticosteroids and tacrolimus administration resolved the rheumatoid arthritis and skin lesions. Rheumatoid vasculitis with acquired reactive perforating collagenosis has not been reported previously...
November 16, 2016: Modern Rheumatology
Carrie Gallivan, Ian Brown, Namrata Setia, Christophe Rosty, Gregory Y Lauwers
No abstract text is available yet for this article.
February 2016: Pathology
Jian-Jun Wen, Xianxiu Wan, John Thacker, Nisha Jain Garg
BACKGROUND: Chagasic cardiomyopathy (CCM) caused by Trypanosoma cruzi (Tc) infection is prevalent in Latin America and recognized as an emerging infectious heart disease in the US. The NO-cGMP-PKG1α pathway maintains cardiac homeostasis and inotropy and may be disturbed due to phosphodiesterase (PDE5) mediated cGMP catabolism in CCM. METHODS AND RESULTS: C57BL/6 mice were infected with Tc, and at the end of acute parasitemia (i.e. 45 days post-infection), treated with sildenafil (SIL, 1 mg/kg) twice per week for 3 weeks...
June 2016: JACC. Basic to Translational Science
Chengwen Fei, Yao Wang, Yu Gong, Hui Xu, Qian Yu, Yuling Shi
BACKGROUND: Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which altered collagen is extruded through the epidermis. There are 2 types of RPC, acquired RPC (ARPC) and inherited RPC, while the latter is extremely rare. Here we report on 1 case of ARPC. METHODS: A 73-year-old female was presented with strongly itchy papules over her back and lower limbs for 3 months. She denied the history of oozing or vesiculation. A cutaneous examination showed diffusely distributed multiple well-defined keratotic papules, 4 to 10 mm in diameter, on the bilateral lower limbs and back as well as a few papules on her chest and forearm...
July 2016: Medicine (Baltimore)
Piotr Zajkowski, Aleksandra Ochal-Choińska
The paper is an update of 2011 Standards for Ultrasound Assessment of Salivary Glands, which were developed by the Polish Ultrasound Society. We have described current ultrasound technical requirements, assessment and measurement techniques as well as guidelines for ultrasound description. We have also discussed an ultrasound image of normal salivary glands as well as the most important pathologies, such as inflammation, sialosis, collagenosis, injuries and proliferative processes, with particular emphasis on lesions indicating high risk of malignancy...
June 2016: Journal of Ultrasonography
Miguel Mauricio Cano Cerro, Eva María Jiménez Fornés, María José Fabrich Lloret, Ovidio Gans Cuenca, Mara Redón Martínez, Elena Sales Molió
The dermatosis known since reactive perforating collagenosis (RPC) is an injury that is characterized by the transepidermal elimination of the collagen. Two forms of presentation exist: the inherited one and the acquired one. The acquired form appears in the adult age, principally in diabetics with renal chronic insufficiency. The hyaluronic acid is a glycosaminoglycan of high place molecular weight that is synthesized in the system vacuolar of the fibroblasts and other cells, since they are the keratinocytes, with help of the factors of growth and in other cytokines...
April 2016: Revista de Enfermería
Sandeep Arora, Ajay Malik, Anil Balki
No abstract text is available yet for this article.
March 2016: Indian Dermatology Online Journal
Randie H Kim, Maryann Kwa, Sylvia Adams, Shane A Meehan, Jennifer A Stein
No abstract text is available yet for this article.
January 2016: JAAD Case Reports
Nikos Sabanis, Eleni Paschou, Eleni Gavriilaki, Asterios Kalaitzoglou, Dimitrios Papanikolaou, Sotiris Vasileiou, Ioannis Amplianitis
Hemodialysis patients present with a broad spectrum of specific and nonspecific skin disorders, which rarely coexist. We report an exceptional case of a hemodialysis patient that developed acquired reactive perforating collagenosis and pseudoporphyric bullous dermatosis on the basis of common skin disorders which include hyperpigmentation, pruritus, xerosis cutis, and Linsday's nails. Interestingly, our patient presented with two unusual but distinctive cutaneous dermopathies on the background of other commonly seen skin alterations...
February 2, 2016: Hemodialysis International
Payapvipapong Kittisak, Masaru Tanaka
No abstract text is available yet for this article.
April 2015: Dermatology Practical & Conceptual
K C Shaw, J R Kaley, M D Darling, J W Patterson, A A Chokoeva, T Lotti, U Wollina, G Tchernev
Perforating folliculitis (PF) describes the process by which altered dermal material is eliminated from the epidermis through a follicular unit resulting in keratotic, follicular papules that favor hair-bearing regions of the forearms, arms, buttocks, and thighs. Diabetes mellitus (DM) and chronic renal failure (CRF) are commonly associated with PF. The more general term, acquired perforating dermatosis, has been applied to PF as well as Kyrle’s disease and the non-inherited form of perforating collagenosis...
January 2015: Journal of Biological Regulators and Homeostatic Agents
Arzu Ataseven, Serra Kayacetin
Acquired reactive perforating collagenosis (ARPC) is commonly recognized as an unusual skin reaction to superficial trauma that is observed in patients with a certain genetic predisposition or underlying diseases, such as diabetes mellitus or renal diseases. We present the unusual case of a 55-year-old female diabetic patient with numerous characteristic dome-shaped nodules, which consisted of central umbilication containing firm keratotic plugs.
April 2012: Eurasian Journal of Medicine
Min Zhou, Lijuan Mao, Ying Wang, Qian Wang, Zhiyun Yang, Shurong Li, Ling Li
BACKGROUND: The aims of this study were to determine whether arterial hypertension could affect the venous system of brain and to find out the consequent pathologic changes of cerebral veins. METHODS: Thirty male Sprague-Dawley rats were divided into 2 groups: a sham-clipped group and a stroke-prone renovascular hypertensive rat group. A 2-kidney 2-clip rat model was used to induce renovascular hypertension in the hypertensive group. Systolic blood pressure was measured by tail cuff once each week...
March 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Tetsuhiko Mimura, Masanori Shimodaira, Minoru Kibata, Akihiro Tsukadaira, Kumiko Shirahata
BACKGROUND: Adult-onset Still's disease is a rare inflammatory condition of unknown origin characterized by high spiking fever, arthralgia, arthritis, myalgia, salmon-colored evanescent rash, and hepatosplenomegaly. The diagnosis of adult-onset Still's disease requires the exclusion of other possible disorders because it lacks specific clinical and histopathological findings. Adult-onset Still's disease rarely become fatal due to visceral involvements such as disseminated intravascular coagulation...
2014: BMC Research Notes
Asmaa Gaber Abdou, Alaa Hassan Maraee, Azza Gaber Antar, Shimaa Fareed
OBJECTIVE: To detect mast cell density by toluidine blue and immunohistochemical staining for mast cell tryptase in skin tags as compared to normal skin to determine whether they have a role in skin tag development. STUDY DESIGN: This study was carried out on 30 patients with skin tags and 10 age- and sex-matched healthy controls without skin tags. RESULTS: There was a significant difference between skin tag and control groups regarding mast cell density evaluated by toluidine blue staining (p = 0...
August 2014: Analytical and Quantitative Cytopathology and Histopathology
Shenqiang Yan, Jinping Wan, Xuting Zhang, Lusha Tong, Song Zhao, Jianzhong Sun, Yuehan Lin, Chunhong Shen, Min Lou
Cerebral venous collagenosis has been implicated in leading to white matter hyperintensities (WMHs) via venous ischemia. We sought to determine whether cerebral venous dilation or ischemia correlate with the severity of WMHs by quantitative in vivo imaging techniques. This was an investigator-initiated prospective single-center study. We reviewed clinical, laboratory data from 158 consecutive WMHs patients and 50 controls, and measured the number of voxels of deep medullary veins (DMVs) on susceptibility-weighted image and assessed the WMH volume (as a marker of the severity of WMHs) on a 3-T magnetic resonance system...
2014: Frontiers in Aging Neuroscience
Mohamed El-Khalawany, Wael Saudi, Abeer Kamel, Sameh Fawzy, Hatem Hassan
Prurigo is a common skin condition characterized by vigorous scratching. Although ulceration is not uncommon in prurigo, a perforating-like lesion was not previously reported. In this study we described series of cases of prurigo with perforating-like lesions and discussed its relation to acquired perforating dermatoses. The study included 32 cases, during the period from 2008 to 2013. Clinical data and histological features were recorded and analyzed. The study included 78.1% males and 21.9% females with a mean age of 39...
December 2014: Pathology, Research and Practice
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