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Myocardial perfusion scan

Jesper J Linde, Mathias Sørgaard, Jørgen T Kühl, Jens D Hove, Henning Kelbæk, Walter B Nielsen, Klaus F Kofoed
The prognostic implications of myocardial computed tomography perfusion (CTP) analyses are unknown. In this sub-study to the CATCH-trial we evaluate the ability of adenosine stress CTP findings to predict mid-term major adverse cardiac events (MACE). In 240 patients with acute-onset chest pain, yet normal electrocardiograms and troponins, a clinically blinded adenosine stress CTP scan was performed in addition to conventional diagnostic evaluation. A reversible perfusion defect (PD) was found in 38 patients (16 %) and during a median follow-up of 19 months (range 12-22 months) 25 patients (10 %) suffered a MACE (cardiac death, non-fatal myocardial infarction and revascularizations)...
October 7, 2016: International Journal of Cardiovascular Imaging
Xiaowei Gong, Haiyan Wang, Yadong Yuan
The present study aimed to investigate the factors affecting the first therapeutic-target-achieving (TTA) time of warfarin therapy in patients with acute pulmonary embolism (PTE). Between January 2008 and June 2013, patients with PTE confirmed by transpulmonary arterial enhanced computed tomographic pulmonary angiography or pulmonary ventilation perfusion scanning were included in the present study. Data collected included demographic information, history of tobacco and alcohol intake, basic diseases (stable and unstable hypertension, diabetes, heart failure, cancer/cerebral infarction, old myocardial infarction and atrial fibrillation), liver and kidney function, the haemoglobin and platelet count of the blood, international normalized ratio monitoring, warfarin dosage adjustment and medication combinations...
October 2016: Experimental and Therapeutic Medicine
Maseeh Uz Zaman, Nosheen Fatima, Areeba Zaman, Unaiza Zaman, Rabia Tahseen
For vasodilator stress, myocardial perfusion imaging (MPI) with at least 12-h caffeine abstinence is recommended, as it attenuates cardiovascular hyperemic response of adenosine and dipyridamole. However, many published conflicting results have shown no significant effect upon perfusion abnormalities in MPI performed without caffeine abstinence. The aim of this study was to compare the hemodynamic changes and negative predictive value (NPV) of normal MPIs with adenosine stress performed with or without caffeine abstinence...
September 2016: World Journal of Nuclear Medicine
Neil Chatterjee, Brandon C Benefield, Kathleen R Harris, Jacob U Fluckiger, Timothy Carroll, Daniel C Lee
PURPOSE: Myocardial perfusion can be quantified using the "dual bolus" technique, which uses two separate contrast boluses to avoid signal nonlinearity in the blood pool. This technique relies on knowing the precise ratio of contrast concentrations between the two boluses. In this study, we investigated the variability found in these ratios, as well as the error it introduces, and developed a method for correction. METHODS: Five dogs received dual bolus myocardial perfusion MRI scans...
September 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Graeme A Keith, Christopher T Rodgers, Michael A Chappell, Matthew D Robson
PURPOSE: A novel method for quantitative measurement of myocardial blood flow (MBF) using arterial spin labeling (ASL) in a single breath-hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability. METHODS: A flow-sensitive alternating inversion recovery (FAIR) ASL method with Look-Locker readout (LL-FAIR-ASL) was implemented at 3 tesla. Scans were performed on 10 healthy volunteers and MBF measured in three slices...
September 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Mathias Sørgaard, Jesper J Linde, Jens D Hove, Jan R Petersen, Tem B S Jørgensen, Jawdat Abdulla, Merete Heitmann, Charlotte Kragelund, Thomas Fritz Hansen, Patricia M Udholm, Christian Pihl, J Tobias Kühl, Thomas Engstrøm, Jan Skov Jensen, Dan E Høfsten, Henning Kelbæk, Klaus F Kofoed
AIMS: Patients admitted with chest pain are a diagnostic challenge because the majority does not have coronary artery disease (CAD). Assessment of CAD with coronary computed tomography angiography (CCTA) is safe, cost-effective, and accurate, albeit with a modest specificity. Stress myocardial computed tomography perfusion (CTP) has been shown to increase the specificity when added to CCTA, without lowering the sensitivity. This article describes the design of a randomized controlled trial, CATCH-2, comparing a clinical diagnostic management strategy of CCTA alone against CCTA in combination with CTP...
September 2016: American Heart Journal
Chung Chan, Hui Liu, Yariv Grobshtein, Mitchel R Stacy, Albert J Sinusas, Chi Liu
PURPOSE: Partial volume correction (PVC) methods typically improve quantification at the expense of increased image noise and reduced reproducibility. In this study, the authors developed a novel voxel-based PVC method that incorporates anatomical knowledge to improve quantification while suppressing noise for cardiac SPECT/CT imaging. METHODS: In the proposed method, the SPECT images were first reconstructed using anatomical-based maximum a posteriori (AMAP) with Bowsher's prior to penalize noise while preserving boundaries...
September 2016: Medical Physics
Yaqi Shen, Xuemei Hu, Xianlun Zou, Di Zhu, Zhen Li, Daoyu Hu
BACKGROUND: Imaging communities have already reached a consensus that the radiation dose of computed tomography (CT) should be reduced as much as reasonably achievable to lower population risks. Increasing attention is being paid to iodinated contrast media (CM) induced nephrotoxicity (CIN); a decrease in the intake of iodinated CM is required by increasingly more radiologists. Theoretically, the radiation dose varies with the tube current time and square of the tube voltage, with higher iodine contrast at low photon energies (Huda et al...
September 2016: International Journal of Clinical Practice
Ashish P Saini, Stephen E Cyran, Steven M Ettinger, Linda B Pauliks
A 15-year-old boy with transposition of the great arteries (TGA) and neonatal arterial switch operation (ASO) presented with complete occlusion of the left main coronary artery (LMCA). Intra-operatively, an intramural left coronary artery was identified. Therefore, since age 7 years he had a series of screening exercise stress tests. At 13 years old, he had 3 to 4 mm ST segment depression in the infero-lateral leads without symptoms. This progressed to 4.2 mm inferior ST segment depression at 15 years old with normal stress echocardiogram...
August 16, 2016: World Journal of Clinical Cases
Yasutaka Ichikawa, Yoya Tomita, Masaki Ishida, Shigeki Kobayashi, Kan Takeda, Hajime Sakuma
BACKGROUND: The current study evaluated the usefulness of a belt technique for restricting respiratory motion of the heart and for improving image quality of (13)N-ammonia myocardial PET/CT, and it assessed the tolerability of the belt technique in the clinical setting. METHODS: Myocardial (13)N-ammonia PET/CT scanning was performed in 8 volunteers on Discovery PET/CT 690 with an optical respiratory motion tracking system. Emission scans were performed with and without an abdominal belt...
August 17, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Helga Castagnoli, Cecilia Ferrantini, Raffaele Coppini, Alessandro Passeri, Katia Baldini, Valentina Berti, Franco Cecchi, Iacopo Olivotto, Roberto Sciagrà
AIMS: Myocardial blood flow <1.1 mL/min/g following dipyridamole (Dip-MBF) assessed by positron emission tomography (PET) was identified in 2003 as an important outcome predictor in hypertrophic cardiomyopathy (HCM), based on scans performed in the 90s. However, such extreme Dip-MBF impairment is rarely observed in contemporary cohorts. We, therefore, reassessed the Dip-MBF threshold defining high-risk HCM patients. METHODS: Dip-MBF was measured using (13)N-ammonia in 100 HCM consecutive patients, prospectively enrolled and followed for 4...
August 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
S P Mironov, A A Ansheles, D N Shulgin, V B Sergienko
OBJECTIVE: to specify frequency, patterns and diagnostic significance of extraosseous soft tissue findings in 99mTc-pyrophosphate skeletal scintigraphy. MATERIAL AND METHODS: Results of skeletal scintigraphy from 1060 patients (447 men, 613 women) were analyzed. Scanning in "whole body" mode started in 3-4 hours after 740 MBq of radiotracer activity intravenous administration, and performed in anterior and posterior projections in continuous table motion mode at rate of 6-8 cm per minute...
March 2016: Vestnik Rentgenologii i Radiologii
Ronaldo Lima, Thais Peclat, Thalita Soares, Caio Ferreira, Ana Carolina Souza, Gabriel Camargo
BACKGROUND: Recent studies have shown that myocardial perfusion imaging (MPI) in cadmium-zinc-telluride (CZT) cameras allow faster exams with less radiation dose but there are little data comparing its prognosis information with that of dedicated cardiac Na-I SPECT cameras OBJECTIVE: The objective of this study is to compare the prognostic value of MPI using an ultrafast protocol with low radiation dose in a CZT-SPECT and a traditional one. METHODS: Group 1 was submitted to a two-day MIBI protocol in a conventional camera, and group 2 was submitted to a 1-day MIBI protocol in CZT camera...
August 10, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Bernard Songy, Mohamed Guernou, Daniel Hivoux, David Attias, David Lussato, Mathieu Queneau, Gerald Bonardel, Marc Bertaux
: The aim of this study was to assess the prognostic value of normal ultra-low-dose exercise MPI with a CZT camera. METHODS: 1901 consecutive patients without known CAD referred for exercise MPI with 1.8 MBq/kg (0.05 mCi) of Tc99m sestamibi or tetrofosmin and a CZT camera were included prospectively. Patients with an abnormal scan requiring an additional resting image (230) or a submaximal exercise test (271) were excluded. The 1400 remaining patients were followed for 39 months...
August 9, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Haonan Wang, Ganesh Adluru, Liyong Chen, Eugene G Kholmovski, Neal K Bangerter, Edward V R DiBella
OBJECTIVE: Simultaneous multi-slice (SMS) imaging is a slice acceleration technique that acquires multiple slices in the same time as a single slice. Radial controlled aliasing in parallel imaging results in higher acceleration (radial CAIPIRINHA or CAIPI) is a promising SMS method with less severe slice aliasing artifacts as compared to its Cartesian counterpart. Here we use radial CAIPI with data undersampling and constrained reconstruction to improve the utility of ungated cardiac perfusion acquisitions...
November 2016: Magnetic Resonance Imaging
Loïc Bière, Martin Audonnet, Guillaume Clerfond, Hermeland Delagarde, Serge Willoteaux, Fabrice Prunier, Alain Furber
PURPOSE: To assess whether a first-pass perfusion sequence (FPP) improved the detection of left ventricular thrombus (LVT). MATERIALS AND METHODS: Three hundred and twenty-nine patients with a first STEMI were prospectively included to undergo cardiac magnetic resonance (CMR) at baseline and after a 3-month follow-up. A CMR delayed analysis was performed by three blinded examiners (2 CMR experts and 1 novice) according to a two-step reading protocol. First, an analysis was performed on cine CMR and late gadolinium enhancement (routine stage)...
September 2016: European Journal of Radiology
Aaron So, Yasuhiro Imai, Brian Nett, John Jackson, Liz Nett, Jiang Hsieh, Gerald Wisenberg, Patrick Teefy, Andrew Yadegari, Ali Islam, Ting-Yim Lee
PURPOSE: The authors investigated the performance of a recently introduced 160-mm/256-row CT system for low dose quantitative myocardial perfusion (MP) imaging of the whole heart. This platform is equipped with a gantry capable of rotating at 280 ms per full cycle, a second generation of adaptive statistical iterative reconstruction (ASiR-V) to correct for image noise arising from low tube voltage potential/tube current dynamic scanning, and image reconstruction algorithms to tackle beam-hardening, cone-beam, and partial-scan effects...
August 2016: Medical Physics
(no author information available yet)
Computed tomography (CT)-based myocardial perfusion imaging (CTP)has been widely recognized as a one-station solution for the imaging of myocardial ischemia-related diseases. This article reviews the clinical scanning protocols,analytical methods,and research advances of CTP in recent years and briefly discusses its limitations and future development.
June 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
D Sheshagiri Rao, Ramachandra Barik
Arterial supply of an intralobar pulmonary sequestration (IPS) from the coronary circulation is extremely rare. A significant coronary steal does not occur because of dual or triple sources of blood supply to sequestrated lung tissue. We present a 60-year-old woman who presented to us with repeated episodes of monomorphic ventricular tachycardia (VT) in last 3 mo. Radio frequency ablation was ineffective. On evaluation, she had right lower lobe IPS with dual arterial blood supply, i.e., right pulmonary artery and the systemic arterial supply from the right coronary artery (RCA)...
July 26, 2016: World Journal of Cardiology
Dharmender Malik, Rajender Basher, Shelvin Vadi, Bhagwant Mittal, Anish Bhattacharya
No abstract text is available yet for this article.
July 25, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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