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Myocardial perfusion scan

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https://www.readbyqxmd.com/read/29447342/diagnosing-coronary-artery-disease-after-a-positive-coronary-computed-tomography-angiography-the-dan-nicad-open-label-parallel-head-to-head-randomized-controlled-diagnostic-accuracy-trial-of-cardiovascular-magnetic-resonance-and-myocardial-perfusion-scintigraphy
#1
L Nissen, S Winther, J Westra, J A Ejlersen, C Isaksen, A Rossi, N R Holm, G Urbonaviciene, L C Gormsen, L H Madsen, E H Christiansen, M Maeng, L L Knudsen, L Frost, L Brix, H E Bøtker, S E Petersen, M Bøttcher
Aims: Perfusion scans after coronary computed tomography angiography (CCTA) in patients with suspected coronary artery disease (CAD) may reduce unnecessary invasive coronary angiographies (ICAs). However, the diagnostic accuracy of perfusion scans after primary CCTA is unknown. The aim of this study was to determine the diagnostic accuracy of cardiac magnetic resonance (CMR) and myocardial perfusion scintigraphy (MPS) against ICA with fractional flow reserve (FFR) in patients suspected of CAD by CCTA...
February 13, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29416252/perioperative-use-of-transthoracic-echocardiography-in-a-patient-with-congenitally-corrected-transposition-of-great-arteries-atrial-septal-defect-and-severe-pulmonary-stenosis-for-lower-segment-cesarean-section
#2
Vikas Saini, Tanvir Samra, Gurpreet Kaur
A 25-year-old female with congenitally corrected transposition of great arteries (CCTGAs), atrial septal defect, and severe pulmonary stenosis underwent lower segment cesarean section at 34 weeks of gestation using combined spinal epidural anesthesia (CSEA). We used transthoracic echocardiography (TTE) for intraoperative monitoring of the cardiovascular system because these patients are reported to have a high prevalence of myocardial perfusion defects, regional wall motion abnormalities, and impaired ventricular contractility...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29360694/attenuation-correction-in-myocardial-perfusion-imaging-affects-the-assessment-of-infarct-size-in-women-with-previous-inferior-infarct
#3
Alessia Peli, Luca Camoni, Valentina Zilioli, Rexhep Durmo, Mattia Bonacina, Francesco Bertagna, Barbara Paghera, Raffaele Giubbini
BACKGROUND: Myocardial perfusion imaging is a well-established diagnostic tool in patients with known or suspected coronary artery disease. Numerous clinical trials have shown that attenuation correction (AC) in single photon emission computed tomography (SPECT) improves the diagnostic accuracy of myocardial perfusion imaging over non-AC SPECT, differentiating between scar and attenuation artifacts. We have previously shown that attenuation artifacts produce an overestimation of the size of inferior infarcts in the male population...
January 22, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29340989/gated-spect-myocardial-perfusion-imaging-with-cadmium-zinc-telluride-detectors-allows-real-time-assessment-of-dobutamine-stress-induced-wall-motion-abnormalities
#4
Rene Nkoulou, Mathias Wolfrum, Aju P Pazhenkottil, Michael Fiechter, Ronny R Buechel, Oliver Gaemperli, Philipp A Kaufmann
BACKGROUND: Left ventricular (LV) ejection fraction (EF) during high dobutamine stress (HD) by real-time gated-SPECT myocardial perfusion imaging (MPI) on a cadmium-zinc-telluride (CZT) gamma camera was validated versus cardiac magnetic resonance imaging (CMR). METHODS AND RESULTS: After injecting 99mTc-tetrofosmin (320 MBq) in 50 patients (mean age 64 +/- 11 years), EF at rest and post-stress as well as relevant changes in EF at HD (ΔEF ≥ 5%) were assessed. CZT and CMR rest EF values yielded an excellent correlation and agreement (r = 0...
January 16, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29340889/quantification-of-myocardial-perfusion-defect-size-in-rats-comparison-between-quantitative-perfusion-spect-and-autoradiography
#5
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Ultra-high resolution single-photon emission computed tomography (SPECT) system, using multiple pinhole collimators, has been applied to the imaging of small rodents. We aimed to compare the myocardial infarction (MI) area on quantitative perfusion single-photon emission computed tomography (QPS; Cedars-Sinai Medical Center, USA) with that on high-resolution autoradiography in rat model to determine the accuracy of perfusion defect measurement by QPS. PROCEDURES: After thoracotomy, rats (n = 9) had their left coronary arteries occluded and reperfused before injection with 185 MBq [99mTc] methoxyisobutylisonitrile ([99mTc]MIBI) for SPECT and autoradiography...
January 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29320864/diagnostic-performance-of-static-single-scan-stress-perfusion-cardiac-computed-tomography-in-detecting-hemodynamically-significant-coronary-artery-stenosis-a-comparison-with-combined-invasive-coronary-angiography-and-cardiovascular-magnetic-resonance-myocardial
#6
Inyoung Song, Jeong Geun Yi, Jeong Hee Park, Mi Young Kim, Je Kyoun Shin, Sung Min Ko
Background Non-invasive anatomical and physiological evaluations of coronary artery disease (CAD) may be obtained with static single-scan stress perfusion cardiac computed tomography (SSPCT). Purpose To determine the diagnostic performance of static SSPCT for identifying hemodynamically significant CAD. Material and Methods This prospective study included 29 patients with suspected or known CAD who underwent static SSPCT, cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI), and invasive coronary angiography (ICA)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29315054/ambulatory-management-of-pulmonary-embolism
#7
Houssam Abusibah, Muntasir M Abdelaziz, Peter Standen, Praveen Bhatia, Mahir Ma Hamad
The diagnosis of pulmonary embolism can be very difficult and elusive. It depends greatly on the use of diagnostic tests, which are in turn interpreted according to a pre-test clinical probability. These include non-specific tests such as the chest X-ray and electrocardiograph, which help exclude other conditions such as pneumonia or myocardial infarction. On the other hand, more specific tests such as computed tomography or ventilation/perfusion scanning are used to confirm or exclude the diagnosis of pulmonary embolism...
January 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29298216/the-utility-of-myocardial-perfusion-imaging-before-renal-transplantation-a-retrospective-analysis
#8
Paul D Callan, Sunil Bhandari, Andrew L Clark, David Eadington, Emmanouil Papadopoulos, Ann C Tweddel
BACKGROUND: Renal transplantation (RT) reduces morbidity and mortality in patients with end-stage renal failure. Myocardial perfusion imaging provides prognostic information in patients with renal failure, but its role before transplantation remains unclear. We performed a retrospective review assessing the prognostic value of technetium-99m sestamibi myocardial perfusion imaging at a tertiary UK centre. PATIENTS AND METHODS: We included scans performed between 2005 and 2012...
January 2, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29296058/myocardial-perfusion-abnormalities-in-asymptomatic-type-2-diabetic-patients
#9
Ghada Al-Humaidi, Ismet Sarikaya, Abdelhamid H Elgazzar, Azu Owunwanne
Objective: The prevalence of coronary artery disease (CAD) is high in patients with diabetes. Because ischemia and infarction are often silent in diabetic patients, diagnosis of CAD occurs inevitably late. It is essential to identify the presence of CAD in diabetic patients to start early treatment. Therefore, the aim of this study was to determine the prevalence of abnormal myocardial perfusion in asymptomatic type 2 diabetic patients using myocardial perfusion imaging. Methods: Fifty-nine patients with type 2 diabetes, who did not have any history of CAD, but did have risk factors underwent myocardial perfusion single-photon emission computed tomography (SPECT) imaging using 99mTc-tetrofosmin and a 2-day stress-rest protocol...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29285726/myocardial-perfusion-in-patients-with-non-ischaemic-systolic-heart-failure-and-type-2-diabetes-a-cross-sectional-study-using-rubidium-82-pet-ct
#10
Christina Byrne, Philip Hasbak, Andreas Kjaer, Jens Jakob Thune, Lars Køber
Both patients with non-ischaemic systolic heart failure and patients with type 2 diabetes (T2DM) often have reduced myocardial blood flow without significant coronary atherosclerosis. However, the mechanisms are not fully understood. The aim of this study was to investigate whether perfusion is reduced additionally when the 2 are combined. In a cross-sectional study, we scanned patients with non-ischaemic systolic heart failure with and without T2DM using Rubidium-82 positron emission tomography/computed tomography at rest and adenosine-induced stress, thereby obtaining the myocardial flow reserve (myocardial flow reserve (MFR) = stress flow/rest flow) as a measure of the myocardial vasomotor function; 28 patients with T2DM and 123 without T2DM were included...
December 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29273695/cardiac-displacement-during-13n-ammonia-myocardial-perfusion-pet-ct-comparison-between-adenosine-and-regadenoson-induced-stress
#11
Elise Vleeming, Sergiy Lazarenko, Friso van der Zant, Xiao-Bo Pan, Jerome Declerck, Maurits Wondergem, Remco Knol
PURPOSE: In this study, differences are investigated in cardiac displacement during adenosine stress versus regadenoson stress in 13N-Ammonia(13NH3) MP PET/CT scans. METHODS: A total of 61 MP PET/CTs were acquired using either adenosine (n=30) or regadenoson (n=31) as a stressor. For both groups, cardiac displacement during rest and stress was measured three-dimensionally, relative to either a fixed reference frame or the previous frame, in each 1-minute frame of a list-mode PET acquisition of 25 minutes...
December 22, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29249347/enhancement-of-dynamic-myocardial-perfusion-pet-images-based-on-low-rank-plus-sparse-decomposition
#12
Lijun Lu, Xiaomian Ma, Hassan Mohy-Ud-Din, Jianhua Ma, Qianjin Feng, Arman Rahmim, Wufan Chen
BACKGROUND AND OBJECTIVE: The absolute quantification of dynamic myocardial perfusion (MP) PET imaging is challenged by the limited spatial resolution of individual frame images due to division of the data into shorter frames. This study aims to develop a method for restoration and enhancement of dynamic PET images. METHODS: We propose that the image restoration model should be based on multiple constraints rather than a single constraint, given the fact that the image characteristic is hardly described by a single constraint alone...
February 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29248657/comprehensive-cardiac-ct-with-myocardial-perfusion-imaging-versus-functional-testing-in-suspected-coronary-artery-disease-the-multicenter-randomized-crescent-ii-trial
#13
Marisa Lubbers, Adriaan Coenen, Marcel Kofflard, Tobias Bruning, Bas Kietselaer, Tjebbe Galema, Marc Kock, Andre Niezen, Marco Das, Marco van Gent, Ewout-Jan van den Bos, Leon van Woerkens, Paul Musters, Suze Kooij, Fay Nous, Ricardo Budde, Miriam Hunink, Koen Nieman
OBJECTIVES: This study sought to assess the effectiveness, efficiency, and safety of a tiered, comprehensive cardiac computed tomography (CT) protocol in comparison with functional testing. BACKGROUND: Although CT angiography accurately rules out coronary artery disease (CAD), incorporation of CT myocardial perfusion imaging as part of a tiered diagnostic approach could improve the clinical value and efficiency of cardiac CT in the diagnostic work-up of patients with angina pectoris...
December 8, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29215412/serial-fdg-pet-ct-imaging-in-the-management-of-cardiac-sarcoidosis
#14
William Bremer, Nadera J Sweiss, Yang Lu
A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. Myocardial perfusion scan demonstrated a moderate sized, fixed perfusion defect along the mid to proximal anteroseptal wall of the left ventricle, with better perfusion on stress images. FDG-PET/CT demonstrated corresponding focal FDG avidity of the mid to proximal anteroseptal wall, suggestive of active cardiac sarcoidosis. Because of severe side effects, mycophenolate mofetil was discontinued, and the patient received low-dose steroid therapy...
February 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29209997/-18f-bms-747158-02pet-imaging-for-evaluating-hepatic-mitochondrial-complex-1dysfunction-in-a-mouse-model-of-non-alcoholic-fatty-liver-disease
#15
Takemi Rokugawa, Sotaro Momosaki, Miwa Ito, Hitoshi Iimori, Yuki Kato, Kohji Abe
BACKGROUND: Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to bind mitochondrial complex-1 (MC-1). The aim of this study was to investigate the potential use of 18F-BMS for evaluating hepatic MC-1 activity in mice fed a methionine- and choline-deficient (MCD) diet. Male C57BL/6J mice were fed a MCD diet for up to 2 weeks. PET scans with 18F-BMS were performed after 1 and 2 weeks of the MCD diet...
December 6, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29197461/ineffective-and-prolonged-apical-contraction-is-associated-with-chest-pain-and-ischaemia-in-apical-hypertrophic-cardiomyopathy
#16
Edward Stephenson, Pierre Monney, Francesca Pugliese, James Malcolmson, Steffen E Petersen, Charles Knight, Peter Mills, Andrew Wragg, Constantinos O'Mahony, Neha Sekhri, Saidi A Mohiddin
OBJECTIVES: To investigate the hypothesis that persistence of apical contraction into diastole is linked to reduced myocardial perfusion and chest pain. BACKGROUND: Apical hypertrophic cardiomyopathy (HCM) is defined by left ventricular (LV) hypertrophy predominantly of the apex. Hyperdynamic contractility resulting in obliteration of the apical cavity is often present. Apical HCM can lead to drug-refractory chest pain. METHODS: We retrospectively studied 126 subjects; 76 with apical HCM and 50 controls (31 with asymmetrical septal hypertrophy (ASH) and 19 with non-cardiac chest pain and culprit free angiograms and structurally normal hearts)...
January 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29184761/estimating-extraction-fraction-and-blood-flow-by-combining-first-pass-myocardial-perfusion-and-t1-mapping-results
#17
Devavrat Likhite, Promporn Suksaranjit, Ganesh Adluru, Brent Wilson, Edward DiBella
Background: Quantifying myocardial perfusion is complicated by the complexity of pharmacokinetic model being used and the reliability of perfusion parameter estimates. More complex modeling provides more information about the underlying physiology, but too many parameters in complex models introduce a new problem of reliable estimation. To overcome the problem of multiple parameters, we have developed a technique that combines knowledge from two different cardiac magnetic resonance (MR) imaging techniques: dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and T1 mapping...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29183415/the-pre-participation-screening-in-young-athletes-which-protocol-do-we-need-exactly
#18
İbrahim I Çetin, Filiz Ekici, Ayşe E Kibar, Murat Sürücü, Ali Orgun
The aim was to assess the utility and feasibility of a comprehensive cardiac screening protocol in young athletes before participation in sports. A total of 380 athletes referring before participation in sports, between April, 2014 and April, 2015, were included in this study. The mean age was 12.4 years. A screening protocol has been applied to all, including personal and family history, physical examination, 12-lead electrocardiography, transthoracic echocardiography, 24-hour rhythm Holter analysis, and treadmill exercise test...
November 29, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29177257/assessment-of-segmental-left-ventricular-thickening-in-diabetic-type-ii-obese-patients-with-normal-myocardial-perfusion-scan
#19
Hanna K Al-Makhamreh, Abedallatif A AlSharif, Mousa A Abujbara, Akram N Al-Ibraheem, Omar S Obeidat, Yazan I AlKawaleet, Aya Darawsheh, Mohammad I Liswi, Kamel M Ajlouni
OBJECTIVE: The aim of this study is to investigate whether gated single photo emission tomography (gSPET) can be used to detect subclinical left ventricular systolic dysfunction (LVSD) in obese diabetic type II patients. SUBJECTS AND METHODS: We retrospectively reviewed gSPET images of 190 patients with diabetes mellitus type II (DM II) (137 females and 53 males) with normal myocardial perfusion and normal ejection fraction (EF). Standardized twenty segment polar maps of thickening and motion were generated...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29168158/assessment-of-attenuation-correction-for-myocardial-pet-imaging-using-combined-pet-mri
#20
Martin Lyngby Lassen, Sazan Rasul, Dietrich Beitzke, Marie-Elisabeth Stelzmüller, Jacobo Cal-Gonzalez, Marcus Hacker, Thomas Beyer
OBJECTIVE: To evaluate the frequency of artifacts in MR-based attenuation correction (AC) maps and their impact on the quantitative accuracy of PET-based flow and metabolism measurements in a cohort of consecutive heart failure patients undergoing combined PET/MR imaging. METHODS: Myocardial viability studies were performed in 20 patients following a dual-tracer protocol involving the assessment of myocardial perfusion ((13)N-NH3: 813 ± 86 MBq) and metabolism ((18)F-FDG: 335 ± 38 MBq)...
November 22, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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