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Myocardial perfusion scan

Piotr J Slomka, Julian Betancur, Joanna X Liang, Yuka Otaki, Lien-Hsin Hu, Tali Sharir, Sharmila Dorbala, Marcelo Di Carli, Mathews B Fish, Terrence D Ruddy, Timothy M Bateman, Andrew J Einstein, Philipp A Kaufmann, Edward J Miller, Albert J Sinusas, Peyman N Azadani, Heidi Gransar, Balaji K Tamarappoo, Damini Dey, Daniel S Berman, Guido Germano
BACKGROUND: We aim to establish a multicenter registry collecting clinical, imaging, and follow-up data for patients who undergo myocardial perfusion imaging (MPI) with the latest generation SPECT scanners. METHODS: REFINE SPECT (REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT) uses a collaborative design with multicenter contribution of clinical data and images into a comprehensive clinical-imaging database. All images are processed by quantitative software...
June 19, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Marvin Grossmann, Andreas A Giannopoulos, Fabiola A Bechtiger, Michael Messerli, Moritz Schwyzer, Dominik C Benz, Ken Kudura, Catherine Gebhard, Christoph Gräni, Aju P Pazhenkottil, Philipp A Kaufmann, Ronny R Buechel
BACKGROUND: The applicability of ultra-low-dose computed tomography (CT) for attenuation correction (AC) of single-photon-emission computed tomography myocardial perfusion imaging (SPECT-MPI) remains elusive. METHODS AND RESULTS: One-hundred patients underwent one-day 99m Tc-tetrofosmin stress-rest MPI and non-contrast enhanced cardiac CT with 120, 80, and 70 kilovolt peak (kVp) tube voltage and tube current of 200 milliamperes for creation of AC maps. Normalized percent myocardial uptake from SPECT-MPI using 80 kVp scans for AC showed excellent correlation vs AC from 120 kVp scans for stress [intraclass correlation (ICC) = 0...
June 19, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
I Made Ady Wirawan, Robin F Griffiths, Peter D Larsen
BACKGROUND: This study aims to examine which marker or testing protocols have been suggested for cardiovascular disease (CVD) risk assessment in asymptomatic populations, at which CVD risk level, and how this can be implemented for CVD risk assessment in pilot populations. METHODS: A systematic search was performed using Systematic Reviews Subset on PubMed; the OvidSP interface, including all EBM reviews and EMBASE databases; and the G-I-N International Guideline Library...
July 1, 2018: Aerospace Medicine and Human Performance
Yunyang Lu, Yingda Feng, Dan Liu, Zhiran Zhang, Kai Gao, Wei Zhang, Haifeng Tang
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (MI/R) injury is a leading factor responsible for damage in myocardial infarction, resulting in additional injury to cardiac tissues involved in oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ), the main constituent of Nigella sativa L. seeds, has been reported to possess various biological activities. However, few reports regarding myocardial protection are available at present. Therefore, this study was conducted aiming to investigate the protective effect of TQ against MI/R injury and to clarify its potential mechanism...
June 15, 2018: Cellular Physiology and Biochemistry
Alan Rozanski, Daniel S Berman
PURPOSE OF REVIEW: This review aims to assess the synergistic use of coronary artery calcium (CAC) scanning and stress-rest SPECT myocardial perfusion imaging (MPI) for the workup of patients with suspected coronary artery disease (CAD). RECENT FINDINGS: The CAC score bears a proportional relationship to both the frequency of obstructive CAD and inducible ischemia. Consequently, the test can be used to improve the Bayesian assessment of pre-test CAD likelihood and assist in triaging patients for stress testing...
June 13, 2018: Current Cardiology Reports
Michael McGee, David Ferreira, Olav Tvedten, Ehsan Mahmoodi, Nicholas Whitehead, David Baker, Stuart Sugito, Allan Davies, Stuart Turner, Andrew Boyle
Myocardial perfusion scanning (MPS) is commonly used to assess patients with an intermediate to high risk of coronary artery disease. Concerns have been raised about the accuracy of this test. There is little recent data regarding the specificity of the MPS in the context of current medical therapy. The primary objective of this study is to determine the specificity of MPS in diagnosing obstructive coronary artery disease. A total of 184 patients fulfilled study criteria. The overall specificity of MPS for obstructive coronary artery disease was 54%...
May 27, 2018: Heart, Lung & Circulation
Mojtaba Ansari, Hoda Hashemi, Mehdi Soltanshahi, Mohsen Qutbi, Zahra Azizmohammadi, Faraj Tabeie, Hamid Javadi, Esmail Jafari, Maryam Barekat, Majid Assadi
OBJECTIVE: Evaluating the effects of heart cavity volume, presence and absence of perfusion defect, gender and type of study (stress and rest) on the difference of systolic parameters of myocardial perfusion scan in 16 and 8 framing gated SPECT imaging. METHODS: Cardiac gated SPECT in both 16 and 8 framing simultaneously and both stress and rest phases at one-day protocol was performed for 50 patients. Data have been reconstructed by filter back projection (FBP) method and left ventricular (LV) systolic parameters were calculated by using QGS software...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Rene Nkoulou, Tobias Fuchs, Aju P Pazhenkottil, Mathias Wolfrum, Ronny R Buechel, Oliver Gaemperli, Philipp A Kaufmann
Aims: We validated a 1-day myocardial perfusion imaging (MPI) protocol using an ultra low-dose(ULD) equal for stress and rest on a cadmium zinc telluride (CZT). Methods and results: Fifty-six patients underwent a 1-day MPI protocol using a standard (SD) 99mTc-tetrofosmin dose at stress (320 MBq) and rest (960 MBq) with 5 min acquisition time each (SD). Within 2 weeks MPI was repeated using ULD 99mTc-tetrofosmin equal for stress and rest (160 MBq) with 15 min acquisition time each (ULD)...
June 2, 2018: European Heart Journal Cardiovascular Imaging
Thomas J Guterbaum, Kristian A Øvrehus, Karsten T Veien, Jacob E Møller, Hans Mickley
BACKGROUND This case study demonstrated that although highly symptomatic, agenesis of the left circumflex artery was a benign finding. Anomalies of the coronary arteries were found to be the cause of sudden death in a young individual. Left circumflex anomalies were not associated with major cardiac events. CASE REPORT A 20-year-old male was admitted due to syncope preceded by chest pain. His electrocardiogram (ECG) showed global ST segment elevation as well as biphasic T waves in anterior precordial leads...
May 2, 2018: American Journal of Case Reports
Michael Bindschadler, Kelley R Branch, Adam M Alessio
Quantitative myocardial blood flow (MBF) estimation by dynamic contrast enhanced cardiac computed tomography (CT) requires multi-frame acquisition of contrast transit through the blood pool and myocardium to inform the arterial input and tissue response functions. Both the input and the tissue response functions for the entire myocardium are sampled with each acquisition. However, the long breath holds and frequent sampling can result in significant motion artifacts and relatively high radiation dose. To address these limitations, we propose and evaluate a new static cardiac and dynamic arterial (SCDA) quantitative MBF approach where (1) the input function is well sampled using either prediction from pre-scan timing bolus data or measured from dynamic thin slice 'bolus tracking' acquisitions, and (2) the whole-heart tissue response data is limited to one contrast enhanced CT acquisition...
May 21, 2018: Physics in Medicine and Biology
Karan Bami, Shrankhala Tewari, Fadi Guirguis, Linda Garrard, Ann Guo, Alomgir Hossain, Terrence D Ruddy, Rob S B Beanlands, Robert A deKemp, Benjamin J W Chow, Girish Dwivedi
BACKGROUND: Cardiac magnetic resonance perfusion studies with adenosine stress have shown that splenic response can identify patients with inadequate pharmacologic stress. We investigate the incremental prognostic impact of splenic response ratio (SRR) in patients with normal Rubidium (Rb)-82 PET myocardial perfusion imaging (MPI). METHODS: Consecutive patients undergoing dipyridamole Rb-82 PET MPI for the evaluation of coronary artery disease were screened. Spleen and liver Rb-82 activity was measured and the SRR was calculated: SRR = (Spleen stress/Liver stress)/(Spleen rest/Liver rest)...
April 12, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Manuel Barreiro-Pérez, Elena Tundidor-Sanz, Ana Martín-García, Elena Díaz-Peláez, Alberto Íscar-Galán, Soraya Merchán-Gómez, María Gallego-Delgado, Javier Jiménez-Candil, Ignacio Cruz-González, Pedro L Sánchez
Magnetic resonance (MR) is considered the gold standard in the assessment of myocardial morphology, function, perfusion, and viability. However, its main limitation is its scarce availability. In 2014, we installed the first MR scanner exclusively managed by a cardiology department within the publicly-funded Spanish healthcare system with the aim of improving patient-care, training and research in the department. In the time interval analyzed, July 2014 to May 2017, 3422 cardiac MR scans were performed (32minutes used per study; 96% with good quality; 75% with contrast media administration)...
May 2018: Revista Española de Cardiología
Jennifer M Renaud, Kai Yi Wu, Kimberly Gardner, May Aung, Rob S B Beanlands, Robert A deKemp
INTRODUCTION: Rubidium-82 (82 Rb) PET is used widely for myocardial perfusion imaging. The purpose of this study was to investigate if an additional saline-push following the 82 Rb elution improves PET image quality. METHODS: 82 Rb PET scans were acquired with and without 26 mL saline-push in six patients as part of a clinical quality improvement program. Dynamic images were analyzed to measure the total activity delivered to the superior vena cava (SVC) and retained in the left ventricle (LV) myocardium...
March 27, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Joris D van Dijk, Eline D Huizing, Jorn A van Dalen, Jorik R Timmer, Pieter L Jager
OBJECTIVE: Qualitative positron emission tomography (PET) myocardial perfusion imaging (MPI) scans are reconstructed with a delay after an injection of rubidium-82 (Rb) to ensure blood pool clearance and sufficient left ventricle to myocardium contrast. Our aim was to derive the minimal starting time of data reconstruction (STDR) after an injection of Rb for which the diagnostic value and image quality remained unaffected. MATERIALS AND METHODS: We retrospectively included 23 patients who underwent rest-stress Rb PET MPI using 740 MBq...
June 2018: Nuclear Medicine Communications
Wen Chong Xin, Xiao Liang Shao, Yue Tao Wang, Jian Feng Wang, Xiao Song Wang, Ling Yang, Wei Yang, Fei Fei Zhang
OBJECTIVE: To evaluate whether computed tomography attention correction (CTAC) has incremental diagnostic value for single photon emission tomography (SPET) myocardial perfusion imaging (MPI) for the detection of coronary artery disease (CAD) in Chinese patients. SUBJECTS AND METHODS: This retrospective study consisted of 181 suspected CAD patients who underwent one-stop SPET examination by MPI combined with a CT scan. Two observers independently evaluated non-attenuation correction (NAC) and CTAC MPI images, and coronary angiography (CAG) results were used as reference standards...
January 2018: Hellenic Journal of Nuclear Medicine
C Fielder Camm, Alexander Emery, Elizabeth Rose-Innes, Sergei Pavlitchouk, Nikant Sabharwal, Andrew D Kelion
BACKGROUND: Using myocardial perfusion scintigraphy (MPS), an increase in left ventricular (LV) volumes or a decrease in ejection fraction (EF) from rest to stress may be clinically important. The variation in these measures between the low-dose stress acquisition and high-dose rest acquisition in a one-day stress-rest protocol has not been established. We assessed the reproducibility of gated volumetric indices between stress and rest and the normal variation in ungated TID ratio for a one-day stress-rest 99m Tc-tetrofosmin protocol...
March 15, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
B Julie He, Brian J Malm, Michelle Carino, Mehran M Sadeghi
BACKGROUND: Myocardial perfusion imaging (MPI) often employs attenuation-correction computed tomography (CTAC) to reduce attenuation artifacts and improve specificity. While there is no specific guideline on how they should be reported, incidental noncardiac findings identified on these scans may be clinically significant. The prevalence of these findings in veterans is not currently known. In addition, variability in reporting these findings may depend on the interpreting physician's specialty...
February 28, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Sabrina Bressieux-Degueldre, Damien Schaffner, Michaël Hofer, Nicole Sekarski, Federica Vanoni
The cause of Kawasaki disease (KD) is still unknown, but an infectious origin and genetic susceptibility have been suggested. The American Heart Association has changed the guidelines for diagnosis and treatment of KD in 2017. One goal is to better identify patients most at risk, particularly young children with « incomplete » KD. In case of intravenous immunoglobulin resistance, alternative treatments to the traditional use of corticosteroids, such as TNF-alpha inhibitors have been proposed. For all patients with coronary aneurisms, regular assessment of myocardial perfusion is recommended, either with stress echocardiography, MRI, scintigraphy or PET-scan...
February 14, 2018: Revue Médicale Suisse
Gianluca Pontone, Daniele Andreini, Andrea I Guaricci, Andrea Baggiano, Fabio Fazzari, Marco Guglielmo, Giuseppe Muscogiuri, Claudio Maria Berzovini, Annalisa Pasquini, Saima Mushtaq, Edoardo Conte, Giuseppe Calligaris, Stefano De Martini, Cristina Ferrari, Stefano Galli, Luca Grancini, Paolo Ravagnani, Giovanni Teruzzi, Daniela Trabattoni, Franco Fabbiocchi, Alessandro Lualdi, Piero Montorsi, Mark G Rabbat, Antonio L Bartorelli, Mauro Pepi
OBJECTIVES: The goal of this study was to evaluate the diagnostic accuracy of stress computed tomography myocardial perfusion (CTP) for the detection of functionally significant coronary artery disease (CAD) by using invasive coronary angiography (ICA) plus invasive fractional flow reserve (FFR) as the reference standard in consecutive intermediate- to high-risk symptomatic patients. BACKGROUND: Stress CTP recently emerged as a potential strategy to combine the anatomic and functional evaluation of CAD in a single scan...
February 9, 2018: JACC. Cardiovascular Imaging
L Nissen, S Winther, J Westra, J A Ejlersen, C Isaksen, A Rossi, N R Holm, G Urbonaviciene, L C Gormsen, L H Madsen, E H Christiansen, M Maeng, L L Knudsen, L Frost, L Brix, H E Bøtker, S E Petersen, M Bøttcher
Aims: Perfusion scans after coronary computed tomography angiography (CCTA) in patients with suspected coronary artery disease (CAD) may reduce unnecessary invasive coronary angiographies (ICAs). However, the diagnostic accuracy of perfusion scans after primary CCTA is unknown. The aim of this study was to determine the diagnostic accuracy of cardiac magnetic resonance (CMR) and myocardial perfusion scintigraphy (MPS) against ICA with fractional flow reserve (FFR) in patients suspected of CAD by CCTA...
April 1, 2018: European Heart Journal Cardiovascular Imaging
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