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https://www.readbyqxmd.com/read/28199935/surgical-management-of-a-giant-parathyroid-adenoma-through-minimal-invasive-parathyroidectomy-a-case-report
#1
Georgios Sahsamanis, Konstantinos Gkouzis, Stavros Samaras, Dionysios Pinialidis, Georgios Dimitrakopoulos
INTRODUCTION: Primary hyperparathyroidism is a common endocrine disorder mostly associated to parathyroid adenomas. Although those tend to be small in size, rare cases of giant parathyroid adenomas may be present. CASE PRESENTATION: A 42year old female was admitted in our department due to weakness and vague abdominal pain for the past 8 months. Preoperative laboratory exams indicated primary hyperparathyroidism as a cause to her symptomatology, with elevated values of parathormone and normal values of serum calcium...
January 31, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28192245/feasibility-and-safety-of-minimally-invasive-radioguided-parathyroidectomy-using-very-low-intraoperative-dose-of-tc-99m-mibi
#2
Mostafa Mehrabibahar, Zohreh Mousavi, Ramin Sadeghi, Parvin Layegh, Masoumeh Nouri, Mehdi Asadi
BACKGROUND: Surgical resection of the abnormal parathyroid glands is the only curative treatment for primary hyperparathyroidism (PHPT). Radioguided parathyroidectomy with technetium-99m (TC-99m) sestamibi has been successfully used in patients with PHPT. This study was designed to evaluate the results of a series of patients with PHPT who underwent minimally invasive radioguided parathyroidectomy (MIRP) using very low dose (1 mCi) of TC-99m sestamibi (MIBI) without application of intraoperative parathyroid hormone (PTH) assay or frozen section analysis...
February 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28155191/left-ventricular-functional-parameters-by-gated-spect-myocardial-perfusion-imaging-in-a-latin-american-country
#3
Miguel Kapitan, Alvaro Beltran, Mario Beretta, Fernando Mut
BACKGROUND: There is paucity of data on left ventricular (LV) functional parameters using gated SPECT myocardial perfusion imaging (MPI) from the Latin American region. This study provides detailed information in low-risk patients both at rest and during exercise. METHODS AND RESULTS: We studied 90 patients (50 men) with a very low likelihood of coronary artery disease. Gated-SPECT MPI was performed with Tc-99m MIBI using a 2-day protocol, with 16 frames/R-R cycle...
February 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28154277/mitochondrial-cardiomyopathy-with-a-unique-99m-tc-mibi-123-i-bmipp-mismatch-pattern
#4
Ryosuke Tashiro, Noriko Onoue, Hiroya Rikimaru, Kenichi Tsukita, Hiroshi Fujita, Nobuhiro Yamaguchi, Takeshi Ishizuka, Yasushi Suzuki, Hiroyoshi Suzuki, Tsuyoshi Shinozaki
A 42-year-old man was referred to our hospital due to chest pain, diabetes mellitus, and sensorineural hearing loss. Transthoracic echocardiography revealed diffuse left ventricular hypokinesis. He was diagnosed with mitochondrial disease and a c.A3243G mutation was identified in his mitochondrial DNA. This case of mitochondrial cardiomyopathy demonstrated a low uptake of (123)I-BMIPP, while the uptake of (99m)Tc-MIBI was preserved. In contrast, previous reports have noted the increased uptake of(123)I-BMIPP and the decreased uptake of (99m)Tc-MIBI...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28131806/-effects-of-prolonged-endocardial-stimulation-on-left-ventricular-mechanical-synchrony-a-pilot-study-applying-gated-spect-phase-analysis-endocardial-stimulation-and-dyssynchrony
#5
Federico Ferrando-Castagnetto, Roberto Ricca-Mallada, Alejandro Vidal, Rodolfo Ferrando
OBJETIVE: To evaluate left ventricular mechanical dyssynchrony (LVMD) associated to prolonged right ventricular pacing through an innovative imaging technique, as a pilot study in Uruguay. METHODS: We performed 99mTc-MIBI gated-SPECT and phase analysis in 12 patients with pacemakers implanted at least one year before scintigraphy due to advanced atrioventricular block. Clinical data, QRS duration, rate, mode and site of pacing in right ventricle, chamber diameters, presence and extension of myocardial scar and ischemia and rest LVEF were recorded...
January 25, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28116482/is-unilateral-neck-surgery-feasible-in-patients-with-sporadic-primary-hyperparathyroidism-and-double-negative-localisation
#6
D M Scott-Coombes, J Rees, G Jones, M J Stechman
INTRODUCTION: Ultrasound and Tc99mMIBI scans are used to localise parathyroid tumours in sporadic primary hyperparathyroidism (pHPT). Intra-operative PTH (ioPTH) assay facilitates unilateral neck exploration (UNE). When both ultrasound and MIBI are negative, it is our policy to explore the left side of the neck and only proceed to bilateral neck exploration (BNE) when either a tumour is not found or when ioPTH does not fall to >50% of the highest pre-excision value. The aim of this study was to investigate the outcome of our approach to 'double negative' patients...
January 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28114223/defining-the-added-value-of-99mtc-mibi-spect-ct-to-conventional-cross-sectional-imaging-in-the-characterization-of-enhancing-solid-renal-masses
#7
Sara Sheikhbahaei, Christopher S Jones, Kristin K Porter, Steven P Rowe, Michael A Gorin, Alex S Baras, Phillip M Pierorazio, Mark W Ball, Takahiro Higuchi, Pamela T Johnson, Lilja B Solnes, Jonathan I Epstein, Mohamad E Allaf, Mehrbod S Javadi
PURPOSE: This study investigates whether the addition of preoperative Tc-MIBI SPECT/CT can increase the degree of diagnostic confidence in the differentiation of benign from malignant enhancing renal masses. PATIENTS AND METHODS: Patients were recruited as part of an institutional review board-approved prospective clinical trial. Forty-eight patients with clinical stage T1 solid renal masses who underwent a Tc-MIBI SPECT/CT before partial or radical nephrectomy were evaluated...
January 20, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28106465/evaluation-of-99m-tc-mibi-in-thyroid-gland-imaging-for-the-diagnosis-and-classification-of-amiodarone-induced-thyrotoxicosis
#8
Junqi Wang, Ruiguo Zhang
OBJECTIVE: Amiodarone-induced thyrotoxicosis (AIT) is caused by aminodaroneas a side effect of cardiovascular disease treatment. Based on the differences in their pathological and physiological mechanisms, many methods have been developed so far to differentiate AIT subtypes such as color flow Doppler sonography (CFDS)and 24 h radioiodine uptake (RAIU). However, these methods suffer from inadequate accuracy in distinguishing different types of AITs and sometimes lead to misdiagnosis and delayed treatments...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28103657/-a-case-of-primary-hyperparathyroidism-complicated-with-hypercalcemic-crisis-during-treatment-with-cinacalcet-and-improved-by-active-treatment
#9
Tomoki Takeda, Atsushi Okada, Rei Unno, Yukihiro Umemoto, Keiichi Tozawa, Takahiro Yasui
A 77-year-old man was referred to our department for surgical treatment of a right ureteral stone identified on computed tomography (CT) during intensive examination for spondylolisthesis of L4-L5. At the initial visit, performance status was 4, and renal dysfunction was identified (Cr 1.3 mg/dl). Corrected calcium level was 11.8 mg/dl, and intact parathyroid hormone level was 555 pg/ml. A CT scan showed a well-defined mass measuring 22×16×20 mm on the right side of the esophagus, along with 99mTc-MIBI uptake in the lesion...
December 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28101172/adenosine-triphosphate-stress-99m-tc-methoxyisobutylisonitrile-gated-myocardial-perfusion-imaging-efficacy-in-diagnosing-stent-restenosis-following-coronary-stent-implantation
#10
Pengfei Zhang, Song Chen, Yang Li, Qiuhong Du, Lijuan Wang, Yingxian Sun, Yaming Li
Coronary stent restenosis rate following implantation is considerably high. The adenosine stress gated myocardial perfusion imaging (G-MPI) method has been widely used in the diagnosis, risk stratification and prognosis evaluation of coronary heart disease; however, the high cost of adenosine limits its clinical application. The aim of the present study was to investigate the efficacy of adenosine triphosphate (ATP) stress (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) G-MPI for diagnosis in-stent restenosis following coronary stent implantation...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28091771/localization-of-parathyroid-adenomas-using-11-c-methionine-pet-after-prior-inconclusive-imaging
#11
Milou E Noltes, Annemieke M Coester, Anouk N A van der Horst-Schrivers, Bart Dorgelo, Liesbeth Jansen, Walter Noordzij, Clara Lemstra, Adrienne H Brouwers, Schelto Kruijff
PURPOSE: Minimally invasive parathyroidectomy (MIP) is the recommended treatment in primary hyperparathyroidism (pHPT) for which accurate preoperative localization is essential. The current imaging standard consists of cervical ultrasonography (cUS) and MIBI-SPECT/CT. (11)C-MET PET/CT has a higher resolution than MIBI-SPECT/CT. The aim of this study was to determine the diagnostic performance of (11)C-MET PET/CT after initial inconclusive or negative localization. METHODS: We performed a retrospective single center cohort study of patients with pHPT undergoing parathyroid surgery after prior negative imaging and later localization by means of (11)C-MET PET/CT between 2006 and 2014...
January 14, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28072625/evaluation-of-a-large-renal-mass-using-99mtc-mibi-spect-ct-in-a-patient-with-chronic-kidney-disease
#12
Steven P Rowe, Michael A Gorin, Mehrbod S Javadi, Mohamad E Allaf
The differentiation of benign and indolent renal masses from aggressive tumor histologies cannot be reliably performed by CT or MRI. Additionally, renal mass biopsy risks complications and has a nondiagnostic rate of 10% to 20%. Tc-MIBI SPECT/CT has been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chormophobe tumors from other more aggressive renal tumor types. We present the case of an 84-year-old man with chronic kidney disease and an 11.2-cm renal mass...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28054182/takotsubo-cardiomyopathy-fdg-myocardial-uptake-pattern-in-fasting-patients-comparison-of-pet-ct-spect-and-echo-results
#13
Malgorzata Kobylecka, Monika Budnik, Janusz Kochanowski, Radoslaw Piatkowski, Marek Chojnowski, Katarzyna Fronczewska-Wieniawska, Tomasz Mazurek, Joanna Maczewska, Michał Peller, Grzegorz Opolski, Leszek Krolicki
BACKGROUND: The aim of this study was to assess the accumulation pattern of 18F-FDG in fasting patients with takotsubo cardiomyopathy (TTC) and to correlate the results with perfusion scintigraphy and echocardiography. METHODS: 18 consecutive patients with TTC were identified by clinical symptoms, cardiac catheterization, and echocardiography. Coronary angiography (CA) and transthoracic echocardiography (TTE) were performed on the day of the onset of symptoms. An assessment of myocardial perfusion (99mTc-MIBI) and glucose metabolism (18F-FDG) was performed within 18 days...
January 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28011189/primary-hyperparathyroidism-regression-associated-to-cinacalcet-therapy-proved-by-99m-tc-mibi-scintigraphy
#14
A Coloma, S Hernández-Estrada, H Bowles, N Sánchez, D Fuster, J Torregrosa
No abstract text is available yet for this article.
December 20, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28004791/free-triiodothyronine-level-correlates-with-myocardial-injury-and-prognosis-in-idiopathic-dilated-cardiomyopathy-evidence-from-cardiac-mri-and-spect-pet-imaging
#15
Wenyao Wang, Haixia Guan, Wei Fang, Kuo Zhang, A Martin Gerdes, Giorgio Iervasi, Yi-Da Tang
Thyroid dysfunction is associated with poor prognosis in heart failure, but theories of mechanisms are mainly based on animal experiments, not on human level. We aimed to explore the relation between thyroid function and myocardial injuries in idiopathic dilated cardiomyopathy (IDCM) using cardiac magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Myocardial fibrosis was detected by late gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was evaluated by (99m)Tc-MIBI SPECT /(18)F-FDG PET imaging...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27994694/-99m-tc-mibi-uptake-in-a-thyroid-adenoma-with-diffuse-adipose-metaplasia
#16
Gaetano Paone, Luca Mazzucchelli, Giuseppe Peloni, Fabrizio Fasolini, Luca Giovanella
A 71-year-old female underwent a (99m)Tc-MIBI scan to characterize a cold nodule (30 mm) of the left thyroid lobe. The nodule showed diffuse uptake and retention of the radiotracer. After resection, histological examination demonstrated a microfollicular adenoma with diffuse white adipose metaplasia. Although mitochondria in brown adipose tissue have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue. Active mitochondria are present in white adipocytes, and this may account for the MIBI uptake, mimicking a hyperproliferation pattern, in our patient(...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27987183/a-gamma-distribution-convolution-model-of-99m-tc-mibi-thyroid-time-activity-curves
#17
Carl A Wesolowski, Surajith N Wanasundara, Michal J Wesolowski, Belkis Erbas, Paul S Babyn
BACKGROUND: The convolution approach to thyroid time-activity curve (TAC) data fitting with a gamma distribution convolution (GDC) TAC model following bolus intravenous injection is presented and applied to (99m)Tc-MIBI data. The GDC model is a convolution of two gamma distribution functions that simultaneously models the distribution and washout kinetics of the radiotracer. The GDC model was fitted to thyroid region of interest (ROI) TAC data from 1 min per frame (99m)Tc-MIBI image series for 90 min; GDC models were generated for three patients having left and right thyroid lobe and total thyroid ROIs, and were contrasted with washout-only models, i...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27867904/incremental-role-of-18-f-fluorocholine-pet-ct-over-technetium-99m-labeled-mibi-scan-in-hyperparathyroidism
#18
Abhishek Behera, Nishikant Avinash Damle
No abstract text is available yet for this article.
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27857527/primary-hyperparathyroidism-jaw-tumor-syndrome-a-confusing-and-forgotten-diagnosis
#19
Doina Piciu, Andra Piciu, Elena Barbus, Claudiu Pestean, Maria Iulia Larg, Bogdan Fetica
BACKGROUND: Primary hyperparathyroidism is caused by the excessive growth of parathormone secretion, its consequence being hypercalcemia. The parathyroid adenoma is responsible for over half of primary hyperparathyroidism cases. The mandibular tumor can be the initial sign in the case of primary hyperparathyroidism. CASE PRESENTATION: We present the case of a 33 year old patient with history of a mandibular operated tumor, repetitive pathological fractures and hypercalcemia manifestations...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27846041/factors-affecting-the-sensitivity-of-tc-99m-methoxyisobutylisonitrile-dual-phase-parathyroid-single-photon-emission-computed-tomography-in-primary-hyperparathyroidism
#20
Mine Araz, Derya Çayir, Mehmet Erdoğan, Bekir Uçan, Erman Çakal
OBJECTIVE: The aim of this study was to investigate the effects of thyroid diseases and regularly used medications on the sensitivity of Tc-99m methoxyisobutylisonitrile (MIBI) dual-phase parathyroid single photon emission computed tomography (SPECT) and to define indicatives of the result of the study. PATIENTS AND METHODS: Overall, 218 primary hyperparathyroidism patients (190 women, 28 men, mean age: 57±14 years) with thyroid-parathyroid ultrasonography and Tc-99m MIBI dual-phase parathyroid SPECT were retrospectively enrolled...
February 2017: Nuclear Medicine Communications
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