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https://www.readbyqxmd.com/read/29036000/unilateral-submandibular-gland-atrophy-and-sialolithiasis-diagnosed-on-99mtc-mibi-spect-ct-in-a-patient-with-primary-hyperparathyroidism
#1
Puskar Pattanayak, Prasanna Santhanam, Mehrbod Som Javadi, Lilja B Solnes, Steven P Rowe
A variety of sequelae of elevated calcium levels are encountered in patients with underlying primary hyperparathyroidism, including stone formation such as calculi in the urinary tract and sialoliths in the salivary glands and ducts. We present a case of a 54-year-old woman with fatigue, myalgia, and poor concentration who was found to have hypercalcemia (corrected calcium, 11.2 mg/dL) and elevated parathyroid hormone level (112 pg/mL), laboratory values consistent with primary hyperparathyroidism. She underwent evaluation with a Tc-MIBI parathyroid SPECT scan that included x-ray CT acquisitions for anatomical localization and attenuation correction...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28993832/-diagnostics-and-treatment-of-primary-hyperparathyroidism
#2
C Nies
Primary hyperparathyroidism is a disease that occurs more frequently than generally thought and is often overlooked. Classical symptoms are bone pain and osteoporosis, renal calculi and peptic ulcers. Many patients are asymptomatic or have unspecific complaints. It is easy to establish the biochemical diagnosis based on calcium and parathormone (PTH) levels and 24-h urine calcium excretion. The most sensitive localization procedures for parathyroid adenomas are sonography and Tc-99(m)-MIBI scintigraphy. The indication for surgery is undisputed in symptomatic patients; however, there is controversy concerning patients without classical symptoms...
October 9, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28991763/normal-values-of-tissue-muscle-perfusion-indexes-of-lower-limbs-obtained-with-a-scintigraphic-method
#3
Nevena Manevska, Sinisa Stojanoski, Daniela Pop Gjorceva, Lidija Todorovska, Daniela Miladinova, Beti Zafirova
Introduction Muscle perfusion is a physiologic process that can undergo quantitative assessment and thus define the range of normal values of perfusion indexes and perfusion reserve. The investigation of the microcirculation has a crucial role in determining the muscle perfusion. Materials and method The study included 30 examinees, 24-74 years of age, without a history of confirmed peripheral artery disease and all had normal findings on Doppler ultrasonography and pedo-brachial index of lower extremity (PBI)...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28988020/management-of-mediastinal-parathyroid-adenoma-via-minimally-invasive-thoracoscopic-surgery-case-report
#4
Saulat Hasnain Fatimi, Hina Inam, Farida Karim Chagan, Usama Khalid Choudry
INTRODUCTION: The most common cause of chronic hypercalcemia is primary hyperparathyroidism (PHPT). However, owing to the diverse presentation of hypercalcemia, the diagnosis often goes unnoticed culminating as a continuum of recurrence of symptoms. Nephrolithiasis, decreased bone mineral density and peptic ulcer disease are the main clinical sequelae. Among the causes of PHPT 80% are caused by parathyroid adenomas (PA). However, only rarely, these adenomas are found ectopically. PRESENTATION OF CASE: We present the case of a 66-year-old female with a history of recurrent renal stones and peptic ulcer disease...
September 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28987702/the-diagnostic-accuracy-of-neck-ultrasound-4d-computed-tomographyand-sestamibi-imaging-in-parathyroid-carcinoma
#5
Ioannis Christakis, Thinh Vu, Hubert H Chuang, Bryan Fellman, Angelica M Silva Figueroa, Michelle D Williams, Naifa L Busaidy, Nancy D Perrier
INTRODUCTION: Our aim was to investigate the accuracy of available imaging modalities for parathyroid carcinoma (PC) in our institution and to identify which imaging modality, or combination thereof, is optimal in preoperative determination of precise tumor location. METHODS: All operated PC patients in our institution between 2000 and 2015 that had at least one of the following in-house preoperative scans: neck ultrasonography (US), neck 4D-Computed Tomography (4DCT) and 99mTc Sestamibi SPECT/CT (MIBI)...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28971656/-should-patients-with-primary-hyperparathyroidism-and-negative-imaging-studies-be-referred-to-surgery
#6
Michal Mekel, Barak Levit, Yoram Kluger, Sophia Ish-Shalom, Elena Segal, Bishara Bishara
INTRODUCTION: Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (PHPT). In cases where imaging fails to demonstrate an adenoma, a bilateral neck exploration (BNE) is performed. Negative imaging is thought to predict surgical failure, and patients with negative imaging are often not referred for surgery. These patients are at risk for disease progression. AIMS: Evaluate the effect of negative imaging on surgical findings and the cure rate in patients with PHPT...
September 2017: Harefuah
https://www.readbyqxmd.com/read/28948350/diagnostic-accuracy-of-an-artificial-neural-network-compared-with-statistical-quantitation-of-myocardial-perfusion-images-a-japanese-multicenter-study
#7
Kenichi Nakajima, Takashi Kudo, Tomoaki Nakata, Keisuke Kiso, Tokuo Kasai, Yasuyo Taniguchi, Shinro Matsuo, Mitsuru Momose, Masayasu Nakagawa, Masayoshi Sarai, Satoshi Hida, Hirokazu Tanaka, Kunihiko Yokoyama, Koichi Okuda, Lars Edenbrandt
PURPOSE: Artificial neural networks (ANN) might help to diagnose coronary artery disease. This study aimed to determine whether the diagnostic accuracy of an ANN-based diagnostic system and conventional quantitation are comparable. METHODS: The ANN was trained to classify potentially abnormal areas as true or false based on the nuclear cardiology expert interpretation of 1001 gated stress/rest (99m)Tc-MIBI images at 12 hospitals. The diagnostic accuracy of the ANN was compared with 364 expert interpretations that served as the gold standard of abnormality for the validation study...
September 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28930839/a-novel-use-of-hill-function-and-utility-of-99mtc-mibi-scintigraphy-to-detect-earlier-lower-extremity-microvascular-perfusion-in-patients-with-type-2-diabetes
#8
Yingsha Li, Qiang Li, Shenju Liang, Xia Liang, Wen Zhou, Hongbo He, Rongbing Jin, Kaifa Wang, Zhiming Zhu, Zhencheng Yan
We use the Hill function to analyze the dynamics of Tc-99m 2 methoxy-isobutyl-isonitrile (Tc-MIBI) scintigraphy data and to examine the earlier lower extremity microvascular perfusion of diabetic patients without typical clinical symptoms and with the preserved normal ankle-brachial index (ABI).Eighty-eight participants (30 healthy control, 34 diabetic patients, and 24 diabetic patients with peripheral arterial disease [PAD]) were recruited and applied Tc-MIBI scintigraphy. Fourteen diabetic patients with PAD also underwent computed tomography angiography (CTA) examination and were performed endovascular interventions...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28902729/comparative-effectiveness-of-ultrasonography-99mtc-sestamibi-and-18f-fluorocholine-pet-ct-in-detecting-parathyroid-adenomas-in-patients-with-primary-hyperparathyroidism
#9
Ntk Thanseer, Sanjay Kumar Bhadada, Ashwani Sood, Bhagwant Rai Mittal, Arunanshu Behera, Arun Kumar Reddy Gorla, Renjith R Kalathoorakathu, Priyanka Singh, Divya Dahiya, Uma Nahar Saikia, Sudhaker D Rao
PURPOSE: Accurate preoperative localization of parathyroid lesion(s) is crucial for successful surgical management of primary hyperparathyroidism (PHPT). This study was conducted to compare the effectiveness of ultrasonography (USG) of the neck, Tc-sestamibi (MIBI) imaging with or without SPECT/CT, and F-fluorocholine (FCH) PET/CT imaging in the preoperative localization of parathyroid lesions in patients with PHPT. METHODS: Fifty-four consecutive patients with PHPT were included in this prospective study who underwent preoperative localization of the parathyroid lesion(s) using 3 diagnostic modalities followed by surgery...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28900880/characterizing-indeterminate-renal-masses-with-molecular-imaging-the-role-of-99m-tc-mibi-spect-ct
#10
REVIEW
Andrew M Reynolds, Kristin Kelly Porter
PURPOSE OF REVIEW: The majority of enhancing renal masses cannot be characterized through imaging as malignant or benign; however, such characterization could save patients from unnecessary surgery and/or biopsy and associated morbidity. Herein, we review the recent literature on the emerging use of (99m)Tc-MIBI SPECT/CT in preoperative differentiation of enhancing renal masses. RECENT FINDINGS: Recent reports have shown that (99m)Tc-MIBI SPECT/CT imaging can differentiate mitochondrial-rich, benign, or indolent renal masses from renal cell carcinoma...
September 12, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28882718/nontraumatic-multiple-vertebral-compression-fractures-induced-by-primary-hyperparathyroidism-a-case-report-and-literature-review
#11
Man Kyu Choi, Sung Min Kim
BACKGROUND: Primary hyperparathyroidism (PHPT) is one of the causes of osteoporosis and is known to increase the fracture risk of bone. However, multiple vertebral compression fracture because of PHPT is extremely rare. CASE DESCRIPTION: A case of acute multiple vertebral compression fracture in a patient with PHPT is described. The fracture occurred suddenly without trauma. The patient had a low T score (-4.4), and serum hypercalcemia and phosphatemia were evident...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28862179/influence-of-single-photon-emission-computed-tomography-spect-reconstruction-algorithm-on-diagnostic-accuracy-of-parathyroid-scintigraphy-comparison-of-iterative-reconstruction-with-filtered-backprojection
#12
Gonca Kara Gedik, Oktay Sari
BACKGROUND & OBJECTIVES: Preoperative localization of parathyroid lesions is essential for improving the results in patients with primary hyperparathyroidism. The purpose of this study was to evaluate retrospectively the value of technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) and to compare the diagnostic accuracy of iterative reconstruction (IR) and filtered backprojection (FBP) reconstruction algorithms about localization of parathyroid lesions...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28827905/clinical-utility-of-tc-99m-mibi-spect-ct-for-preoperative-localization-of-parathyroid-lesions
#13
Zeynep Gozde Ozkan, Seher Nilgun Unal, Serkan Kuyumcu, Yasemin Sanli, Mehmet Fatih Gecer, Beyza Ozcinar, Yasemin Senyurek Giles, Yesim Erbil
We aimed to demonstrate the role of SPECT/CT in preoperative localization of parathyroid lesions in patients with hyperparathyroidism who had technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) dual-phase parathyroid scintigraphy. We evaluated retrospectively the scintigraphic data of 103 patients who had parathyroidectomy after Tc-99m MIBI dual-phase parathyroid scintigraphy with SPECT/CT. The planar and SPECT/CT images were evaluated separately to determine their efficacy in localizing parathyroid lesions...
August 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28823060/cardiac-death-in-patients-with-left-ventricular-aneurysm-remodeling-and-myocardial-viability-by-gated-99m-tc-mibi-spect-and-gated-18-f-fdg-pet
#14
Weixue Wang, Xiang Li, Congna Tian, Shihua Zhao, Marcus Hacker, Xiaoli Zhang
(1) To evaluate the prognostic value of LV remodeling parameters in patients with LV aneurysm by gated SPECT (GSPECT), gated PET (GPET) and CMR; (2) to evaluate the impact of myocardial viability and LV remodeling on the long-term cardiac survival in patients with LV aneurysm. One hundred and twenty-six consecutive patients underwent GPET, GSPECT and CMR within two weeks, with a mean follow-up of 3.9 ± 1.5 years. End-diastolic volume (EDV, mL) and end-systolic volume (ESV, mL) measured by GPET, GSPECT and CMR and corrected for BSA; EDVI and ESVI were calculated...
August 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28819506/-parathyroid-carcinoma-about-a-case-and-review-of-the-literature
#15
REVIEW
Naourez Kolsi, Sondos Jellali, Jamel Koubaa
Parathyroid carcinoma is a very rare malignant tumor of the parathyroid gland. Clinically, this cancer is characterized by the presence of severe primary hyperparathyroidism. Diagnosis is based on histological examination but is not always easy. Surgery is the treatment of choice. We report the case of a 59-year old woman with a personal history of arterial hypertension and of recurrent renal lithiasis, presenting with diffuse bone pain associated with asthenia. Neck examination showed hard basi-cervical swelling with nonpalpable lower edge...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28815093/a-case-of-hyperparathyroidism-due-to-a-large-intrathyroid-parathyroid-adenoma-with-recurrent-episodes-of-acute-pancreatitis
#16
Kazunori Kageyama, Noriko Ishigame, Aya Sugiyama, Akiko Igawa, Takashi Nishi, Satoko Morohashi, Hiroshi Kijima, Makoto Daimon
We report a case of a 66-year-old woman who developed hyperparathyroidism due to a large intrathyroid parathyroid adenoma with episodes of acute pancreatitis. She had previously been treated for acute pancreatitis twice. Serum calcium was 12.4 mg/dL, and intact parathyroid hormone was 253 pg/dL. Ultrasonography and computed tomography of the neck with contrast enhancement revealed a soft tissue mass (28 mm transverse diameter) within the left lobe of the thyroid. (99m)Tc-MIBI scintigraphy demonstrated focal accumulation due to increased radiotracer uptake in the left thyroid lobe...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#17
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28811539/intraoperative-parathyroid-localization-with-near-infrared-fluorescence-imaging-using-indocyanine-green-during-total-parathyroidectomy-for-secondary-hyperparathyroidism
#18
Le Cui, Yang Gao, Heping Yu, Min Li, Birong Wang, Tao Zhou, Qinggang Hu
The detection of all glands during total parathyroidectomy (TPTX) in secondary hyperparathyroidism (SHPT) patients is often difficult due to their variability in number and location. The objective of this study was to evaluate the feasibility of near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) for intraoperative parathyroid gland (PTG) localization in SHPT patients. Twenty-nine patients with SHPT were divided into two groups with or without intraoperative NIRF imaging. ICG was administered in patients undergoing intraoperative imaging, and the fluorescence of PTGs was assessed...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810550/2d-sti-combined-with-gated-99-tc-m-mibi-mpi-for-the-diagnosis-of-myocardial-ischemia-in-hypercholesterolemia-patients
#19
Yi Song, Rui-Fang Zhang, Yu Liu
This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them to 2D-STI, gated transthoracic Doppler echocardiography (TTDE), and (99)Tc(m)-methoxyisobutylisonitrile myocardial perfusion imaging ((99)Tc(m)-MIBI MPI). The sensitivity, specificity and diagnostic accordance rate of TTDE and 2D-STI for myocardial ischemia in HoFH patients were compared with the (99)Tc(m)-MIBI scores...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28806349/dual-phase-99mtc-mibi-imaging-and-the-expressions-of-p-gp-gst-%C3%AF-and-mrp1-in-hyperparathyroidism
#20
Jianjun Xue, Yan Liu, Danrong Yang, Yan Yu, Qianqian Geng, Ting Ji, Lulu Yang, Qi Wang, Yuanbo Wang, Xueni Lu, Aimin Yang
OBJECTIVE: The aim of this study was to further elucidate the mechanisms of dual-phase technetium-99m methoxyisobutylisonitrile (Tc-MIBI) parathyroid imaging by exploring the association between early uptake results (EUR), delayed uptake results (DUR), and the retention index (RI) in dual-phase Tc-MIBI parathyroid imaging and P glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and glutathione S-transferase-π (GST-π) expression in hyperparathyroidism (HPT). PATIENTS AND METHODS: Preoperative dual-phase (early and delayed) Tc-MIBI imaging was performed on 74 patients undergoing parathyroidectomy for HPT...
October 2017: Nuclear Medicine Communications
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