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Babak Fallahi, Davood Beiki, Yalda Salehi, Alireza Emami-Ardekani, Armaghan Fard-Esfahani, Farahnaz Aghahosseini, Mahdi Haghighatafshar, Mohammad Eftekhari
OBJECTIVE: With respect to the equivocal value of the reverse perfusion pattern (RPP) in technetium-99m (Tc)-sestamibi myocardial perfusion imaging, a study was carried out to evaluate this pattern in association with the presence or absence of coronary artery disease (CAD) and other underlying factors, mainly the time of acquisition and the presence of intense visceral uptake. PATIENTS AND METHODS: We prospectively studied 102 patients with a moderate risk of CAD (41 men and 61 women, mean age: 56...
October 4, 2016: Nuclear Medicine Communications
Mohana Krishnan Baskar, Prakhya Balakrishna Murthy
Effects of pyrethroids (beta-cyfluthrin, bifenthrin, cypermethrin, deltamethrin, lambda-cyhalothrin, and permethrin) on the burst parameters (mean burst rate [MBR], percent spikes in burst [PSB], mean burst duration [MBD], mean spikes in burst [MSB], mean interspike interval in burst [MISIB], and mean interburst interval [MIBI]) have been investigated using the microelectrode array technique. Rat cortical neuronal networks (between 24 and 35 DIV) were exposed to the five accumulative concentrations of pyrethroids (0...
October 13, 2016: Neurotoxicology
G Scerrino, M Attard, C Lo Piccolo, A Attard, G I Melfa, C Raspanti, M Zarcone, S Bonventre, S Mazzola, G Gulotta
INTRODUCTION AND OBJECTIVES: Primary hyperparathyroidism (PHPT) can be found in concomitance with thyroid disease (TD) in a high frequency of cases. In this context the diagnostic exams for localizing the enlarged parathyroid(s) gland(s) could be less reliable or nonconclusive. Moreover, the thyroid carcinoma seems to be more frequent compared to that isolated thyroid desease and, therefore, carefully investigated. The main goal of the present study is to evaluate which diagnostic tool (US, MIBI) is more reliable for localizing the site of the PTH hypersecretion and to confirm if it is always advantageous a combination of both exams...
May 2016: Il Giornale di Chirurgia
Parjeet Kaur, Raghav Gattani, Alka Ashmita Singhal, Deepak Sarin, Sowrabh Kumar Arora, Ambrish Mithal
CONTEXT: Preoperative localization of parathyroid adenoma is essential in deciding the surgical approach of parathyroidectomy. AIM: To describe clinical and biochemical profile, evaluate preoperative imaging modalities and surgical approach in patients with primary hyperparathyroidism (PHPT). METHODOLOGY: This was a retrospective study conducted at the single institution. All patients who underwent evaluation and surgery for PHPT from 2011 to 2015 were included in the study...
September 2016: Indian Journal of Endocrinology and Metabolism
Mélanie Gahier Penhoat, Delphine Drui, Catherine Ansquer, Eric Mirallie, Yves Maugars, Pascale Guillot
We report the case of a patient who presented with multiple brown tumors as the inaugural manifestation of primary hyperparathyroidism. Tc-99m hexakis methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy demonstrated increased radiotracer uptake by the bone lesions. The patient was a 65-year-old male who sought advice for a swelling on his right shin. An osteolytic lesion was visible on the radiograph. A bone biopsy showed a benign tumor containing abundant osteoclastic cells. Laboratory abnormalities included hypercalcemia (3...
October 7, 2016: Joint, Bone, Spine: Revue du Rhumatisme
Federico Ferrando-Castagnetto, Roberto Ricca-Mallada, Alejandro Vidal, Fabián Martínez, Rodolfo Ferrando
Pacemaker stimulation is associated with unpredictable severe cardiac events. We evaluated left ventricular mechanical dyssynchrony (LVMD) during prolonged septal right ventricular pacing. We performed 99mTc-MIBI gated-SPECT and phase analysis in 6 patients with pacemakers implanted at least one year before scintigraphy due to advanced atrioventricular block. Using V-Sync of Emory Cardiac Toolbox we obtained phase bandwidth (PBW) and standard deviation (PSD) from rest phase histogram. Clinical variables, QRS duration, rate and mode of pacing in septal right ventricle wall, chamber diameters, presence and extension of myocardial scar and ischemia and rest LVEF were recorded...
2016: Medicina
Zohar Keidar, Elena Solomonov, Rachel Karry, Alex Frenkel, Ora Israel, Michal Mekel
PURPOSE: Minimally invasive surgery for parathyroid adenomas (PTA) requires precise identification and localization of the diseased gland prior to exploration for optimal surgical planning. The Perrier classification allows for accurate, reproducible, and reliable description of PTA location and communication of clinically significant information to surgeons. The current study compares the Perrier localization of PTA on [(99m)Tc]methoxyisobutylisonitrile ([(99m)Tc]MIBI) single-photon emission computed tomography (SPECT)/X-ray computed tomography (CT) with the results of surgery...
October 4, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
A Dionne, M Bakloul, C Manlhiot, B W McCrindle, M Hosking, C Houde, D Pepelassis, N Dahdah
Coronary artery (CA) aneurysms are serious complications of Kawasaki disease (KD) responsible for ischemic events. Percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are reported with limited data on indications and comparative efficacy. Retrospective multicenter comparison of CA intervention following KD is performed in this study. Twenty two cases were available from 5 centers, of whom 11 underwent CABG, 10 PCI and 1 systemic thrombolysis. Age at intervention (8.3 ± 3.9 vs 11...
September 23, 2016: Pediatric Cardiology
Maseeh Uz Zaman, Nosheen Fatima, Areeba Zaman, Unaiza Zaman, Rabia Tahseen
For vasodilator stress, myocardial perfusion imaging (MPI) with at least 12-h caffeine abstinence is recommended, as it attenuates cardiovascular hyperemic response of adenosine and dipyridamole. However, many published conflicting results have shown no significant effect upon perfusion abnormalities in MPI performed without caffeine abstinence. The aim of this study was to compare the hemodynamic changes and negative predictive value (NPV) of normal MPIs with adenosine stress performed with or without caffeine abstinence...
September 2016: World Journal of Nuclear Medicine
Britta Klein, Thomas Haggeney, Daniela Fietz, Sivanjah Indumathy, Kate L Loveland, Mark Hedger, Sabine Kliesch, Wolfgang Weidner, Martin Bergmann, Hans-Christian Schuppe
STUDY QUESTION: Which immune cells and cytokine profiles are characteristic for testicular germ cell neoplasia and what consequences does this have for the understanding of the related testicular immunopathology? SUMMARY ANSWER: The unique immune environment of testicular germ cell neoplasia comprises B cells and dendritic cells as well as high transcript levels of IL-6 and other B cell supporting or T helper cell type 1 (Th1)-driven cytokines and thus differs profoundly from normal testis or inflammatory lesions associated with hypospermatogenesis...
October 2016: Human Reproduction
Leilei Yuan, Jun Liu, Ying Kan, Jigang Yang, Xufu Wang
BACKGROUND: 99mTc-sestamibi (MIBI) parathyroid SPECT is generally regarded as the best preoperative localizing method in patients with hyperparathyroidism (HPT). However, 99mTc-MIBI SPECT is false negative in approximately 25% of adenomas. 11C-methionine positron emission tomography (PET) has been used in HPT with negative 99mTc-MIBI SPECT scan results. PURPOSE: To systematically review and conduct a meta-analysis of published data on the performance of 11C-methionine PET in patients with HPT with negative 99mTc-MIBI SPECT...
September 2, 2016: Acta Radiologica
Bailing Hsu, Lien-Hsin Hu, Bang-Hung Yang, Lung-Ching Chen, Yen-Kung Chen, Chien-Hsin Ting, Guang-Uei Hung, Wen-Sheng Huang, Tao-Cheng Wu
OBJECTIVES: The aim of this study was to evaluate the accuracy of myocardial blood flow (MBF) quantitation of (99m)Tc-Sestamibi (MIBI) single photon emission computed tomography (SPECT) compared with (13)N-Ammonia (NH3) position emission tomography (PET) on the same cohorts. BACKGROUND: Recent advances of SPECT technologies have been applied to develop MBF quantitation as a promising tool to diagnose coronary artery disease (CAD) for areas where PET MBF quantitation is not available...
September 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Benedetta Badii, Fabio Staderini, Caterina Foppa, Lorenzo Tofani, Ileana Skalamera, Giulia Fiorenza, Eva Qirici, Fabio Cianchi, Giuliano Perigli
BACKGROUND: The purpose of this study was to evaluate the usefulness of the routine intraoperative intact parathyroid hormone (IOPTH) assay, the role of unilateral and bilateral cervical exploration and of preoperative imaging, and to do a cost-benefit analysis in parathyroidectomy for primary hyperparathyroidism. METHODS: Two hundred sixty-four patients who underwent operations between January 2000 and March 2015 were retrospectively divided into 2 groups. RESULTS: Group A (IOPTH) was composed of 64 patients...
August 24, 2016: Head & Neck
Ronaldo Lima, Thais Peclat, Thalita Soares, Caio Ferreira, Ana Carolina Souza, Gabriel Camargo
BACKGROUND: Recent studies have shown that myocardial perfusion imaging (MPI) in cadmium-zinc-telluride (CZT) cameras allow faster exams with less radiation dose but there are little data comparing its prognosis information with that of dedicated cardiac Na-I SPECT cameras OBJECTIVE: The objective of this study is to compare the prognostic value of MPI using an ultrafast protocol with low radiation dose in a CZT-SPECT and a traditional one. METHODS: Group 1 was submitted to a two-day MIBI protocol in a conventional camera, and group 2 was submitted to a 1-day MIBI protocol in CZT camera...
August 10, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Ghobad Azizi, Kelé Piper, James M Keller, Michelle L Mayo, David Puett, Karly M Earp, Carl D Malchoff
OBJECTIVES: This study prospectively determines the shear wave elastography characteristics of parathyroid adenomas using virtual touch imaging quantification, a non-invasive ultrasound based shear wave elastography method. METHODS: This prospective study examined 57 consecutive patients with biochemically proven primary hyperparathyroidism and solitary parathyroid adenoma identified by ultrasound and confirmed by at least one of the following: surgical resection, positive Technetium-99m Sestamibi Scintigraphy (MIBI) scan, or fine needle aspiration biopsy with positive PTH washout (performed only in MIBI negative patients)...
September 2016: European Journal of Radiology
Naoko Nose, Kazuhito Fukushima, Constantin Lapa, Rudolf A Werner, Mehrbod Som Javadi, Junichi Taki, Takahiro Higuchi
UNLABELLED: Coronary flow reserve (CFR), defined as the ratio of maximum coronary flow increase from baseline resting blood flow, is one of the most sensitive parameters to detect early signs of coronary arteriosclerosis at the microvascular level. Myocardial perfusion PET is a well-established technology for CFR measurement, however, availability is still limited. The aim of this study is to introduce and validate myocardial flow reserve measurement by myocardial perfusion SPECT. METHODS: Myocardial perfusion SPECT at rest and ATP stress (0...
November 1, 2016: International Journal of Cardiology
Nishikant Avinash Damle, Madhavi Tripathi, Abhishek Behera, Sameer Aggarwal, Chandrasekhar Bal, Shipra Aggarwal, Vivek Aggarwal, Devasenathipathi Kandasamy, Sameer Taywade
Recently, the role of (18)F-choline in the detection of parathyroid adenomas has been reported. At our institution, we are currently studying the role of this tracer in comparison to the standard methoxy-isobutyl-isonitrile.(MIBI) scan with single photon emission tomography/computed tomography. Our initial results show that (18)F-choline is at least as good as 99mTc-MIBI scan. We present here a representative case of a 45-year-old woman with multiple skeletal lytic lesions and a high parathyroid hormone.(PTH) who underwent both these imaging techniques with concordant results, further confirmed by histopathology and postoperative fall in serum PTH levels...
July 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Leonardo Pippa Gadioli, Carlos Henrique Miranda, Antonio Osvaldo Pintya, Alexandre Baldini de Figueiredo, André Schmidt, Benedito Carlos Maciel, José Antonio Marin-Neto, Marcus Vinicius Simões
BACKGROUND: To investigate the correlation between the extent of myocardial sympathetic denervation and fibrosis and the presence of degrees of severity of ventricular arrhythmias in chronic Chagas cardiomyopathy (CCC). METHODS: Forty-three CCC patients with left ventricular ejection fraction (LVEF) ≥ 35% were divided into three groups: SVT group-presenting Sustained Ventricular Tachycardia (SVT) (n = 15), NSVT group-exhibiting episodes of non-SVT (NSVT) on 24-h Holter monitoring (n = 11), and Control group-exhibiting neither SVT nor episodes of NSVT (n = 17)...
July 5, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Qiang Fu, Qian Zhang, Wen Lu, Yuetao Wang, Yijie Huang, Yanjiong Wang, Qiang Wu, Cunzhi Lu
In this study, our aim was to assess the coronary flow reserve (CFR) by performing the adenosine stress (99m)Tc-MIBI single-photon computed tomographic (SPECT) myocardial perfusion imaging in patients with hypertension. 47 hypertensive patients with normal coronary angiography were divided into 2 groups, defined by the presence (LVH, n = 22) and absence (non-LVH, n = 25) of left ventricular hypertrophy with 17 normal cases as controls. All patients were administered the adenosine stress-rest (99m)Tc-MIBI scintigraphy...
November 2015: Cell Biochemistry and Biophysics
Osman Beton, Ozge Kurmus, Lale Dinc Asarcikli, Buket Alibazoglu, Haluk Alibazoglu, Mehmet Birhan Yilmaz
OBJECTIVE: We aimed to differentiate ischemic heart failure (HF) from non-ischemic HF in patients presenting with non-acute onset exertional dyspnea using technetium-99m methoxyisobutylisonitrile gated single photon emission tomography ((99m)Tc-MIBI gSPET) imaging. SUBJECTS AND METHODS: One hundred and seventy nine consecutive patients with exertional dyspnea without concomitant chest pain referred to (99m)Tc-MIBI gSPET imaging were included in this study. All patients had a newly diagnosed HF with reduced ejection fraction (HFrEF)...
May 2016: Hellenic Journal of Nuclear Medicine
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