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https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#1
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29628185/revisiting-colorectal-cancer-animal-model-an-improved-metastatic-model-for-distal-rectosigmoid-colon-carcinoma
#2
Rui Caetano-Oliveira, Marcos António Gomes, Ana Margarida Abrantes, Edgar Tavares-Silva, Marco Carvalho Oliveira, Mafalda Laranjo, Débora Basílio Queirós, João Casalta-Lopes, Salomé Pires, Lina Carvalho, Rosa Gouveia, Paulo Rodrigues Santos, Denise Gonçalves Priolli, José Guilherme Tralhão, Maria Filomena Botelho
Colorectal cancer (CRC) is the second most frequent and fatal cancer in Western countries. Understanding its biology with different incidence along the colon and rectum, genetic profile and how these factors contribute to local/distant progression, has been hampered by the lack of a suitable CRC model. We report a reproducible model, using human CRC cell lines (CL) (WiDr, LS1034, C2BBe1) injected (1 × 107 cells/animal) in RNU rats (n = 55) which underwent cecostomy and descending colostomy with mucosal-cutaneous fistula of the sigmoid colon...
March 13, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29616419/clinical-presentation-and-management-of-patients-with-primary-hyperparathyroidism-in-italy
#3
F Saponaro, F Cetani, A Repaci, U Pagotto, C Cipriani, J Pepe, S Minisola, C Cipri, F Vescini, A Scillitani, A Salcuni, S Palmieri, C Eller-Vainicher, I Chiodini, B Madeo, E Kara, E Castellano, G Borretta, L Gianotti, F Romanelli, V Camozzi, A Faggiano, S Corbetta, L Cianferotti, M L Brandi, M L De Feo, A Palermo, G Vezzoli, F Maino, M Scalese, C Marcocci
PURPOSE: Evaluation of the phenotype of primary hyperparathyroidism (PHPT), adherence to International Guidelines for parathyroidectomy (PTx), and rate of surgical cure. METHOD: From January 2014-January 2016, we performed a prospective, multicenter study in patients with newly diagnosed PHPT. Biochemical and instrumental data were collected at baseline and during 1-year follow-up. RESULTS: Over the first year we enrolled 604 patients (age 61 ± 14 years), mostly women (83%), referred for further evaluation and treatment advice...
April 3, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29605629/tissue-muscle-perfusion-assessed-by-one-day-99m-tc-mibi-rest-dipyridamol-scintigraphy-in-non-diabetic-and-diabetic-patients
#4
N Manevska, S Stojanoski, D Pop Gjorceva, L Todorovska, M Vavlukis, V Majstorov
AIM: To determine the perfusion reserve of the lower limbs using the method99m Tc-MIBI (rest-dipyridamole) perfusion scintigraphy (one-day protocol) in the diagnostic evaluation of peripheral artery disease (PAD) in patients with and without diabetes mellitus (DM). MATERIAL AND METHODS: We performed tissue-muscle perfusion scintigraphy (TMPS) of the lower limbs, through one-day rest-dipyridamole protocol with99m Tc-MIBI in 24 patients, divided in two groups according to the presence of diabetes - patients with DM (Dp) 13/24 (54%), 2 males and 9 female patients, age 63±13 years and patients without DM (NDp) 11/24 (46%), 3 males and 10 females, age 61±14 years...
March 28, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29572848/experimental-validation-of-absolute-spect-ct-quantification-for-response-monitoring-in-breast-cancer
#5
Angela Collarino, Lenka M Pereira Arias-Bouda, Renato A Valdés Olmos, Pieternel van der Tol, Petra Dibbets-Schneider, Lioe-Fee de Geus-Oei, Floris Hp van Velden
PURPOSE: Recent developments in iterative image reconstruction enable absolute quantification of SPECT/CT studies by incorporating compensation for collimator-detector response, attenuation and scatter as well as resolution recovery into the reconstruction process (Evolution; Q.Metrix package; GE Healthcare). The aim of this experimental study is to assess its quantitative accuracy for potential clinical 99m Tc-sestamibi (MIBI)-related SPECT/CT application in neoadjuvant chemotherapy response studies in breast cancer...
March 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29550844/is-there-an-association-between-hibernating-myocardium-and-left-ventricular-mechanical-dyssynchrony-in-patients-with-myocardial-infarction
#6
Feifei Zhang, Wei Yang, Yuetao Wang, Haipeng Tang, Jianfeng Wang, Xiaoliang Shao, Ziyi Wang, Xiaoying Zhang, Ling Yang, Xiaosong Wang, Weihua Zhou
OBJECTIVE: Left ventricular mechanical dyssynchrony (LVMD) is an important factor in the prognosis of patients with myocardial infarction (MI). The aim of this study is to identify the influencing factors of LVMD in MI patients by radionuclide myocardial imaging. SUBJECTS AND METHODS: This study consisted of 91 patients who had a history of definite prior MI and underwent both technetium-99m methoxyisobutylisonitrile (99m Tc-MIBI) gated single photon emission tomography (SPET) myocardial perfusion imaging (MPI) and18 F-FDG positron emission tomography (PET) myocardial metabolic imaging...
March 20, 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29549631/combined-braf-v600e-analysis-and-99m-tc-mibi-scintigraphy-can-be-a-useful-diagnostic-tool-in-differentiated-thyroid-cancer-patients-with-incomplete-bio-chemical-response-to-first-radioiodine-therapy-rait-a-pilot-investigation
#7
A Campennì, R M Ruggeri, M Siracusa, S A Pignata, F Di Mauro, A Vento, F Trimarchi, S Baldari
PURPOSE: The aim of the present study was to evaluate the possible diagnostic role of the combined performance of BRAF mutation analysis and MIBI scintigraphy in papillary thyroid cancer (PTC) patients with incomplete bio-chemical response to first radioiodine therapy (RAIT) performed for thyroid remnant ablation. METHODS: The records of 15 PTC patients with bio-chemical incomplete response to first RAIT were retrospectively analyzed. BRAFV600E analysis on primary tumor samples was obtained in all cases along with neck ultrasonography and99m Tc-MIBI scintigraphy of the neck-thorax regions at first follow-up...
March 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29541206/treatment-with-20-s-ginsenoside-rg3-reverses-multidrug-resistance-in-a549-ddp-xenograft-tumors
#8
Chao Liu, Quan Gong, Ting Chen, Juan Lv, Zhiping Feng, Pengjie Liu, Zhiyong Deng
Multidrug resistance (MDR) is an obstacle for cancer chemotherapy. It was reported that 20(S)-ginsenoside Rg3 (hereafter Rg3) was able to regulate MDR in mouse leukemia cells. The present study investigated the effect of Rg3 on the MDR of A549 lung cancer cells. A cell viability assay revealed that Rg3 treatment increased cisplatin (DDP) cytotoxicity in DDP resistant A549 cells (A549/DDP). Furthermore, Rg3 increases the antitumor effect of DDP on A549/DDP xenograft mice. The expression of MDR-mediated proteins, including P-glycoprotein (P-gp), multidrug resistance-associated protein (MPR1) and lung resistance protein 1 (LPR1), was detected in tumor tissue of A549/DDP xenograft mice...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29517577/contrast-enhanced-computed-tomography-does-not-improve-the-diagnostic-value-of-parathyroid-dual-phase-mibi-spect-ct
#9
Trine B Andersen, Ramune Aleksyniene, Søren K Boldsen, Michael Gade, Henrik Bertelsen, Lars J Petersen
OBJECTIVE: The aim of this study was to investigate the contribution of contrast-enhanced computed tomography (CE-CT) to the localization of parathyroid adenomas compared with the dual-phase Tc-99m MIBI SPECT with low-dose CT (LD-CT). PATIENTS AND METHODS: This retrospective study included consecutive patients with primary hyperparathyroidism who underwent a preoperative dual-phase MIBI SPECT/CT followed by surgical resection. The standard of care was dual-phase MIBI SPECT/CT, acquired with LD-CT in the early phase and CE-CT in the late phase (SPECT/CE-CT)...
March 6, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29516131/-18-f-fluorocholine-pet-ct-in-the-assessment-of-primary-hyperparathyroidism-compared-with-99m-tc-mibi-or-99m-tc-tetrofosmin-spect-ct-a-prospective-dual-centre-study-in-100-patients
#10
Mohsen Beheshti, Lukas Hehenwarter, Zeinab Paymani, Gundula Rendl, Larisa Imamovic, Rupert Rettenbacher, Oleksiy Tsybrovskyy, Werner Langsteger, Christian Pirich
PURPOSE: In this prospective study we compared the accuracy of18 F-fluorocholine PET/CT with that of99m Tc-MIBI or99m Tc-tetrofosmin SPECT/CT in the preoperative detection of parathyroid adenoma in patients with primary hyperparathyroidism. We also assessed the value of semiquantitative parameters in differentiating between parathyroid hyperplasia and adenoma. METHODS: Both18 F-fluorocholine PET/CT and99m Tc-MIBI/tetrofosmin SPECT/CT were performed in 100 consecutive patients with biochemical evidence of primary hyperparathyroidism...
March 8, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29511573/selective-venous-sampling-supports-localization-of-adenoma-in-primary-hyperparathyroidism
#11
Masaya Ikuno, Takayuki Yamada, Yasumoto Shinjo, Tsuyoshi Morimoto, Reiko Kumano, Kunihiro Yagihashi, Takuyuki Katabami, Yasuo Nakajima
Background: Selective venous sampling (SVS) is an invasive localization study for persistent or recurrent hyperparathyroidism. Purpose: To assess the role of SVS in addition to non-invasive imaging for primary hyperparathyroidism (pHPT). Material and Methods: This study was approved by the institutional review board and included 14 patients who underwent SVS and subsequent parathyroidectomy between January 2014 and April 2017 following a clinical diagnosis of pHPT...
February 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29461127/mibi-scintigraphy-of-parathyroid-adenomas-correlation-with-biochemical-and-histological-markers
#12
Michael Cordes, Otto Dworak, Thomas Papadopoulos, Stephan Coerper, Torsten Kuwert
PURPOSE: In this study, we tested the hypothesis that MIBI-positive and MIBI-negative adenomas of parathyroid glands (APGs) have distinct biochemical and histological markers that could help differentiate MIBI-positive from MIBI-negative APGs. PATIENTS AND METHODS: 40 patients with 41 APGs were included in the study. Patients were enrolled in the study after MIBI scintigraphy examinations had been carried out. Biochemical analyses included serum levels of calcium (Ca), intact parathyroid hormone (iPTH), and 25-hydroxyvitamin D3 (25-OH-D3)...
February 20, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29404934/biochemical-and-pathologic-factors-affecting-technetium-99m-methoxyisobutylisonitrile-imaging-results-in-patients-with-primary-hyperparathyroidism
#13
Aysenur Ozderya, Sule Temizkan, Aylin Ege Gul, Sule Ozugur, Kenan Cetin, Kadriye Aydin
OBJECTIVE: Technetium 99 m methoxyisobutylisonitrile (Tc-99m MIBI) scintigraphy represents the most commonly utilized imaging modality for the detection of the diseased gland in patients with primary hyperparathyroidism (PHPT). In this study, we aimed to identify potential biological factors with an impact on MIBI sensitivity. METHODS: A total of 147 patients with surgically confirmed parathyroid adenomas were assessed retrospectively. Data including medical history, biochemical and hormonal measurements, cervical US, Tc-99m MIBI scans as well as pathology reports were retrieved and recorded...
May 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29398672/low-dose-erythropoietin-in-patients-with-st-segment-elevation-myocardial-infarction-epo-ami-ii-%C3%A3-a-randomized-controlled-clinical-trial
#14
Tetsuo Minamino, Shuichiro Higo, Ryo Araki, Shungo Hikoso, Daisaku Nakatani, Hiroshi Suzuki, Takahisa Yamada, Masaaki Okutsu, Kouji Yamamoto, Yasushi Fujio, Yoshio Ishida, Takuya Ozawa, Kiminori Kato, Ken Toba, Yoshifusa Aizawa, Issei Komuro
BACKGROUND: Erythropoietin (EPO) has antiapoptotic and tissue-protective effects, but previous clinical studies using high-dose EPO have not shown cardioprotective effects, probably because of platelet activation and a lack of knowledge regarding the optimal dose. In contrast, a small pilot study using low-dose EPO has shown improvement in left ventricular function without adverse cardiovascular events.Methods and Results:We performed a multicenter (25 hospitals), prospective, randomized, double-blind, placebo-controlled, dose-finding study to clarify the efficacy and safety of low-dose EPO in patients with ST-segment elevation myocardial infarction (STEMI) under the Evaluation System of Investigational Medical Care of the Ministry of Health, Labor and Welfare of Japan...
February 2, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29392434/classic-primary-hyperparathyroidism-versus-normocalcemic-and-normohormonal-variants-do-they-really-differ
#15
Andreas Kiriakopoulos, Athanasios Petralias, Dimitrios Linos
BACKGROUND: Normocalcemic (NCpHPT) and normohormonal (NHpHPT) variants have been recognized primary hyperparathyroidism entities that pose serious challenges. We sought to define the differences among them in a series of surgically treated patients. PATIENTS AND METHODS: Between 2011 and 2015, 149 patients were enrolled into three groups: CpHPT (Ca > 10.2 mg/dL, PTH > 65 pg/mL), NCpHPT (normal Ca, PTH > 65 pg/mL) and NHpHPT (Ca > 10.2 mg/dL, normal PTH)...
February 1, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29384931/superior-mediastinal-typical-carcinoid-detected-by-99mtc-mibi-spect-ct-imaging-a-case-report
#16
Chenghui Lu, Zenghua Wang, Guoqiang Wang, Xufu Wang, Xinfeng Liu
RATIONALE: This is a rare case of mediastinal typical carcinoid tumor with elevated parathyroid hormone (PTH) and hypercalcemia detected by Tc -methoxy-isobutyl-isonitrile(Tc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT) imaging. PATIENT CONCERNS: A 65-year-old male patient presented with hypercalcemia and elevated PTH. DIAGNOSES: The preoperative diagnosis was ectopic parathyroid adenoma in the right superior mediastinum...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383524/dna-double-strand-breaks-in-blood-lymphocytes-induced-by-two-day-99mtc-mibi-myocardial-perfusion-scintigraphy
#17
Matthias Rief, Lisa Hartmann, Dominik Geisel, Felicitas Richter, Winfried Brenner, Marc Dewey
OBJECTIVES: To investigate DNA double-strand breaks (DSBs) in blood lymphocytes induced by two-day 99mTc-MIBI myocardial perfusion scintigraphy (MPS) using y-H2AX immunofluorescence microscopy and to correlate the results with 99mTc activity in blood samples. METHODS: Eleven patients who underwent two-day MPS were included. DSB blood sampling was performed before and 5min, 1h and 24h after the first and second radiotracer injections. 99mTc activity was measured in each blood sample...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29360693/the-relationship-between-semiquantitative-parameters-derived-from-technetium-99m-metoxyisobutylisonitrile-dual-phase-parathyroid-single-photon-emission-computed-tomography-images-and-disease-severity-in-primary-hyperparathyroidism
#18
Derya Çayir, Mine Araz, Ali Yalçindağ, Erman Çakal
OBJECTIVE: The relationship between multiple semiquantitative indices on technetium-99m metoxyisobutylisonitrile (Tc-99m MIBI) parathyroid single-photon emission computed tomography (SPECT) and clinical, laboratory, and radiological data was investigated in primary hyperparathyroidism. PATIENTS AND METHODS: Ninety-three patients who had a histopathologically confirmed single parathyroid adenoma (PT) were enrolled. Regions of interests were drawn around the PT, neighboring thyroid (T), and background in early and late planar images and isocontour regions of interests around the adenoma in SPECT images (PT SPECT)...
April 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29352568/dual-energy-computed-tomography-should-be-a-first-line-preoperative-localization-imaging-test-for-primary-hyperparathyroidism-patients
#19
Jake Hiebert, Cameron Hague, Shangmei Hou, Sam M Wiseman
BACKGROUND: The objective of this study was to evaluate the performance of dual-energy computed tomography (DECT) for preoperative parathyroid tumor (PT) localization in primary hyperparathyroid (PHP) patients. METHODS: A retrospective review was carried out of the medical records of all PHP patients who underwent ultrasound (US), Tc-99m sestamibi noncontrast single photon emission computed tomography (CT-MIBI), DECT and parathyroidectomy at a single center. RESULTS: The sensitivities and accuracies for preoperative PT localization in the 97 patient study population were: US 40% and 93%, CT-MIBI 64...
January 5, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29340889/quantification-of-myocardial-perfusion-defect-size-in-rats-comparison-between-quantitative-perfusion-spect-and-autoradiography
#20
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Ultra-high resolution single-photon emission computed tomography (SPECT) system, using multiple pinhole collimators, has been applied to the imaging of small rodents. We aimed to compare the myocardial infarction (MI) area on quantitative perfusion single-photon emission computed tomography (QPS; Cedars-Sinai Medical Center, USA) with that on high-resolution autoradiography in rat model to determine the accuracy of perfusion defect measurement by QPS. PROCEDURES: After thoracotomy, rats (n = 9) had their left coronary arteries occluded and reperfused before injection with 185 MBq [99mTc] methoxyisobutylisonitrile ([99mTc]MIBI) for SPECT and autoradiography...
January 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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