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https://www.readbyqxmd.com/read/28489921/time-trend-of-neurocysticercosis-in-children-with-seizures-in-a-tertiary-hospital-of-western-nepal
#1
Kalipatnam Seshagiri Rao, Sudhir Adhikari, Eva Gauchan, Brijesh Sathian, Ganesh B K, Sahisnuta Basnet, Prabhat Kumar Tiwari, Namraj Bahadur, Rajnish Mishra
INTRODUCTION: Neurocysticercosis is a common cause of seizure disorders in children of Western Nepal. The clinical presentation is variable. The incidence varies depending on the food habits and ethnicity of the population. The present study was undertaken with the objective of studying the mode of presentation, radiological findings and to determine the recent trend of the disease in children of Western Nepal. METHODS: Records from the Department of Pediatrics, Manipal Teaching Hospital, Pokhara, Nepal of children aged 0-17 years admitted from 2003 to 2015 and with the discharge diagnosis of seizure and neurocysticercosis (NCC) were reviewed...
May 10, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28488581/repurposing-albendazole-new-potential-as-a-chemotherapeutic-agent-with-preferential-activity-against-hpv-negative-head-and-neck-squamous-cell-cancer
#2
Farhad Ghasemi, Morgan Black, Frederick Vizeacoumar, Nicole Pinto, Kara M Ruicci, Carson Cao Son Huu Le, Matthew R Lowerison, Hon Sing Leong, John Yoo, Kevin Fung, Danielle MacNeil, David A Palma, Eric Winquist, Joe S Mymryk, Paul C Boutros, Alessandro Datti, John W Barrett, Anthony C Nichols
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using a series of in vitro assays, we assessed the ability of albendazole to inhibit proliferation in 20 HNSCC cell lines across a range of albendazole doses (1 nM-10 μM). Cell lines that responded to treatment were further examined for cell death, inhibition of migration and cell cycle arrest. Thirteen of fourteen human papillomavirus-negative HNSCC cell lines responded to albendazole, with an average IC50 of 152 nM...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28484563/primary-hydatid-cyst-of-pineal-region-of-brain-a-case-report-from-saudi-arabia
#3
Ahmed Bakhsh, Khalid Mukarram Ali Siddiqui, Suad Taraif
Preoperative diagnosis of cerebral echinococcosis in an unusual location is always difficult. Nonetheless, this possibility should be kept in mind in all cystic lesions of the brain. Although total excision of the cyst without rupture is a time - tested treatment, but in order to prevent recurrence, adjuvant medical treatment should also be started. Albendazole, mebenadazole and praziquental are commonly used drugs. Albendazole is a drug of choice. Its usual dose for adults is 400 mg twice daily. Exact duration of treatment is still uncertain, but it should not be <6 months...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28480835/case-series-study-of-hepatic-echinococcal-cysts-in-serbia-viability-of-scolices-seropositivity-and-epidemiological-characteristics
#4
I Colovic Calovski, A Barac, Z Golubovic, A Karamarkovic, S Mitrovic, M Milicevic, M Cvetkovic, A M Dzamic
Cystic echinococcosis (CE) is an endemic helminthic disease caused by infection with Echinococcus granulosus metacestodes. Although CE is endemic in the Balkan region, the exact epidemiology remains unknown. We conducted a case-series study with the aim of evaluating the correlation between seropositivity, socio-epidemiological data, pre-operative treatment with albendazole and viability of protoscolices in human hepatic hydatid cysts. Consecutive patients with hepatic CE underwent surgery to extract E. granulosis cysts...
May 8, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28473227/evaluating-the-predictability-of-the-in-vitro-transfer-model-and-in-vivo-rat-studies-as-a-surrogate-to-investigate-the-supersaturation-and-precipitation-behaviour-of-different-albendazole-formulations-for-humans
#5
Aaron Ruff, René Holm, Edmund S Kostewicz
The present study investigated the ability of the in vitro transfer model and an in vivo pharmacokinetic study in rats to investigate the supersaturation and precipitation behaviour of albendazole (ABZ) relative to data from a human intestinal aspiration study reported in the literature. Two lipid based formulation systems, a hydroxypropyl-β-cyclodextrin (HPβCD) solution and the addition of a crystallization inhibitor (HPMC-E5) on the behaviour of ABZ was investigated. These formulations were investigated to represent differences in their ability to facilitate supersaturation within the small intestine...
May 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28472383/effect-of-anthelmintic-treatment-on-insulin-resistance-a-cluster-randomized-placebo-controlled-trial-in-indonesia
#6
Dicky L Tahapary, Karin de Ruiter, Ivonne Martin, Eric A T Brienen, Lisette van Lieshout, Christa M Cobbaert, Pradana Soewondo, Yenny Djuardi, Aprilianto E Wiria, Jeanine J Houwing-Duistermaat, Erliyani Sartono, Johannes Wa Smit, Maria Yazdanbakhsh, Taniawati Supali
Background: Emerging evidence suggests that helminth infections are associated with lower insulin resistance (IR). Current deworming programmes might remove this helminth-associated protective effect. Therefore, we evaluated the anthelmintic treatment effect on changes in IR. Methods: We conducted a double-blind household-cluster-randomized placebo-controlled clinical trial on Flores island, Indonesia, an area endemic for soil-transmitted helminths (STH). All subjects received four rounds of three-monthly albendazole or matching placebo for three consecutive days...
May 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28468527/spinal-racemose-cysticercosis-case-report-and-review
#7
Hussam A Yacoub, Ira Goldstein, Mohammad El-Ghanem, Leroy Sharer, Nizar Souayah
Cysticercosis is a common helminthic infection worldwide, endemic in Central and South America, sub-Saharan Africa, and Southeast Asia. Neurocysticercosis typically involves brain parenchyma, subarachnoid space, and the ventricular system. Although the spinal cord is frequently involved in patients with parenchymal neurocysticercosis, isolated spinal involvement is rare, occurring in only 1-3% of patients. We report a case of racemose spinal neurocysticercosis with brain parenchyma involvement in a 49-year-old Mexican man, who presented with unsteady gait and bilateral arm numbness and weakness...
May 4, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28460612/hepatic-capillariasis-drug-targets
#8
Abhishek Dubey, Antara Bagchi, Disha Sharma, Kunal Nandy, Amit Dey, Rajaram Sharma
Zoonotic infections are increasingly becoming public health menaces and are usually transmitted to humans due to unsuitable environmental conditions. One of them is hepatic capillariasis, caused by the parasite Capillaria hepatica, primarily a disease of rodents, with hepatic manifestations in humans. Although its prevalence is very low, it can cause significant morbidity and mortality, with cases reported from all over the world. The main infective form for humans is the embryonated egg of the parasite, which hatch in the intestine and ultimately colonize the liver...
April 27, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28459017/cystic-echinococcosis-a-neglected-disease-at-usual-and-unusual-locations
#9
Soma Sarkar, Himansu Roy, Puranjay Saha, Mallika Sengupta, Krisnendu Sarder, Manideepa Sengupta
Echinococcus granulosus causes a zoonotic infection called cystic echinococcosis (CE) or more commonly known as hydatid disease. Although the two most common locations of hydatid cyst are liver and lung, it may also appear in other parts of the body. Clinical presentation of the hydatid disease depends on the site and size of the lesion. A retrospective study was done in Medical College and Hospital, Kolkata, from January 2012 to June 2014, to find the site of involvement, distribution, clinical features, history of contact, mode of presentation, laboratory diagnosis, and treatment modalities of the cases of hydatid cyst...
January 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/28458073/community-directed-mass-drug-administration-is-undermined-by-status-seeking-in-friendship-networks-and-inadequate-trust-in-health-advice-networks
#10
Goylette F Chami, Andreas A Kontoleon, Erwin Bulte, Alan Fenwick, Narcis B Kabatereine, Edridah M Tukahebwa, David W Dunne
Over 1.9 billion individuals require preventive chemotherapy through mass drug administration (MDA). Community-directed MDA relies on volunteer community medicine distributors (CMDs) and their achievement of high coverage and compliance. Yet, it is unknown if village social networks influence effective MDA implementation by CMDs. In Mayuge District, Uganda, census-style surveys were conducted for 16,357 individuals from 3,491 households in 17 villages. Praziquantel, albendazole, and ivermectin were administered for one month in community-directed MDA to treat Schistosoma mansoni, hookworm, and lymphatic filariasis...
April 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28449690/daily-home-fortification-with-iron-as-ferrous-fumarate-versus-nafeedta-a-randomised-placebo-controlled-non-inferiority-trial-in-kenyan-children
#11
Emily M Teshome, Pauline E A Andang'o, Victor Osoti, Sofie R Terwel, Walter Otieno, Ayşe Y Demir, Andrew M Prentice, Hans Verhoef
BACKGROUND: We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous fumarate in Kenyan children aged 12-36 months. In addition, we updated a recent meta-analysis to assess the efficacy of home fortification with iron-containing powders, with a view to examining diversity in trial results. METHODS: We gave chemoprevention by dihydroartemisinin-piperaquine, albendazole and praziquantel to 338 afebrile children with haemoglobin concentration ≥70 g/L...
April 28, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28449427/trichuris-trichiura-infection-in-north-korean-defector-resulted-in-chronic-abdominal-pain-and-growth-retardation
#12
Jong Bin Kim, Kwang Il Seo, Won Moon
Trichuris trichiura infection is a common helminth infection, which is transmitted via soil, with worldwide distribution, especially in rural areas of developing countries. Occasionally, sporadic cases occur in non-endemic, developed areas due to the widespread of immigration. We experienced a case of Trichuris dysentery syndrome in a young North Korean defector, who had been suffering from chronic abdominal pain for 10 years. He is relatively short and thin compared with his older brother. Unexpectedly, the diagnosis, made by a colonoscopy, revealed numerous, small, white, and gently moving worms at the cecum and ascending colon...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28431589/t2-relaxometry-helps-prognosticate-seizure-outcome-in-patients-with-solitary-cerebral-cysticercosis
#13
Aaron de Souza, Atchayaram Nalini, Jitender Saini, Kandavel Thennarasu
OBJECTIVE: Correlate serial T2 relaxometry (T2R) values with long term seizure outcome in patients with solitary cerebral cysticercosis (SCC) in order to establish its usefulness as a prognostic marker in these patients. METHODS: Patients with new-onset seizures due to SCC were imaged serially using a pre-determined MRI protocol at enrolment and after 3, 6, 12 and 24months. T2 relaxometry was performed using a dual echo sequence with maps generated manually from the measured image intensities at the level of the lesion...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28427692/treatment-resistant-neuromyelitis-optica-spectrum-disorders-associated-with-toxocara-canis-infection-a-case-report
#14
Daisuke Kambe, Kayo Takeoka, Kenta Ogawa, Kosuke Doi, Haruhiko Maruyama, Ayako Yoshida, Toshihiko Suenaga, Takashi Kageyama
A 53-year-old woman was admitted to the department of neurology in Tenri Hospital because of progressive thoracic myelitis a month after she had eaten uncooked bovine liver. A previous episode of right optic neuritis and a positive test for serum anti-aquaporin-4 antibodies indicated a diagnosis of neuromyelitis optica spectrum disorders. Although the patient initially recovered with the reduction of anti-aquaporin-4 antibodies during treatment with intravenous methylprednisolone infusion and plasma exchange, her neurological symptoms deteriorated soon after the completion of plasma exchange...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28406909/sustained-effectiveness-of-weekly-iron-folic-acid-supplementation-and-regular-deworming-over-6-years-in-women-in-rural-vietnam
#15
Gerard J Casey, Ta T Tinh, Nong T Tien, Sarah Hanieh, Luca T Cavalli-Sforza, Antonio Montresor, Beverley-Ann Biggs
BACKGROUND: Weekly iron-folic acid (IFA) supplementation and regular deworming is effective for the prevention of iron deficiency and anaemia in women of child-bearing age. Between 2006 and 2013, a program of weekly IFA and biannual deworming was implemented in Yen Bai province, Vietnam. In this study we aimed to determine the effectiveness of the program in reducing anaemia and the prevalence of hookworm infection after 72 months (six years). METHODS: This prospective cohort study followed up a cohort of 389 women of child-bearing age from baseline until six years after the introduction of the weekly IFA (one tablet containing 200 mg ferrous sulphate, 0...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28380118/in-vitro-efficacy-of-latex-and-purified-papain-from-carica-papaya-against-strongyloides-venezuelensis-eggs-and-larvae
#16
Dayane Moraes, Marcelo Arantes Levenhagen, Julia Maria Costa-Cruz, Antônio Paulino da Costa, Rosângela Maria Rodrigues
Latex from Carica papaya is rich in bioactive compounds, especially papain, which may help to control parasitic diseases. This study evaluated the efficacy of latex from C. papaya and purified papain against Strongyloides venezuelensis. The Egg Hatching Test (EHT) and the Larval Motility Test (LMT) using fresh and frozen latex (250mg/mL), lyophilized latex (34mg/mL), and purified papain (2.8 mg/mL) were performed. Albendazole (0.025 mg/mL) and ivermectin (316 ppm) were used as positive controls. EHT and LMT were carried out through the incubation of each solution with S...
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28372977/effect-of-3-years-of-biannual-mass-drug-administration-with-albendazole-on-lymphatic-filariasis-and-soil-transmitted-helminth-infections-a-community-based-study-in-republic-of-the-congo
#17
Sébastien D S Pion, Cédric B Chesnais, Gary J Weil, Peter U Fischer, François Missamou, Michel Boussinesq
BACKGROUND: The standard treatment strategy of mass drug administration with ivermectin plus albendazole for lymphatic filariasis cannot be applied in central Africa, because of the risk of serious adverse events in people with high Loa loa microfilaraemia. Thus, alternative strategies are needed. We investigated one such alternative strategy for mass drug administration for elimination of lymphatic filariasis and soil-transmitted helminth infections in Republic of the Congo. METHODS: In 2012, we started a 3 year community trial of biannual mass administration of albendazole in a village in Republic of the Congo...
March 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28371660/exposure-of-heligmosomoides-polygyrus-and-trichuris-muris-to-albendazole-albendazole-sulfoxide-mebendazole-and-oxantel-pamoate-in%C3%A2-vitro-and-in%C3%A2-vivo-to-elucidate-the-pathway-of-drug-entry-into-these-gastrointestinal-nematodes
#18
Noemi Cowan, Charles Meier, Anna Neodo, Jennifer Keiser
Millions of people are treated with anthelmintics to control soil-transmitted helminth infections; yet, drug distribution in the plasma and gastrointestinal tract compartments and the pathway of drug uptake into gastrointestinal nematodes responsible for the pharmacological effect are unknown. We assessed the distribution and uptake of albendazole, albendazole sulfoxide, albendazole sulfone in the hookworm Heligmosomoides polygyrus in vitro and in vivo as well as the distribution and uptake of albendazole, mebendazole, and oxantel pamoate in the whipworm Trichuris muris in vitro and invivo...
March 24, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28370210/the-effect-of-three-monthly-albendazole-treatment-on-th2-responses-differential-effects-on-ige-and-il-5
#19
Karin de Ruiter, Dicky L Tahapary, Linda Wammes, Aprilianto E Wiria, Firdaus Hamid, Lisette van Lieshout, Johannes W A Smit, Jeanine J Houwing-Duistermaat, Erliyani Sartono, Taniawati Supali, Maria Yazdanbakhsh
Helminth parasites induce a strong Th2 response, characterized by high levels of IgE and elevated signature cytokines such as IL-5. As many global deworming programs are underway, there is concern that this might lead to emergence of Th1-mediated pathologies when the counterbalancing helminth-induced Th2 response is absent. Therefore, we assessed the effect of deworming on Th2 mediated responses in a household-clustered randomised controlled trial in Indonesia. Total plasma IgE and whole-blood IL-5 responses to mitogen phytohaemagglutinin (PHA) were measured in 1494 and 682 subjects respectively, at baseline, 9 and 21 months after three-monthly single dose treatment with albendazole or placebo...
March 31, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28369129/reaching-endpoints-for-lymphatic-filariasis-elimination-results-from-mass-drug-administration-and-nocturnal-blood-surveys-south-gujarat-india
#20
Anjali Modi, Sukesha Gamit, Bharat S Jesalpura, George Kurien, Jayendra K Kosambiya
BACKGROUND: Following the World Health Assembly resolution on Elimination of lymphatic filariasis (ELF) as a public health problem by the year 2020, a Global Program (GPELF) was launched in 1997 to help endemic countries to initiate national programs. The current strategy to interrupt transmission of LF, is administration of once-yearly, single-dose, two-drug regimen (Albendazole with Diethylcarbamazine (DEC) to be used in endemic areas with the goal of reaching 65% epidemiological coverage for 4-6 years...
April 2017: PLoS Neglected Tropical Diseases
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