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https://www.readbyqxmd.com/read/29651095/validation-of-ultrasound-bioimaging-to-predict-worm-burden-and-treatment-efficacy-in-preclinical-filariasis-drug-screening-models
#1
Amy E Marriott, Hanna Sjoberg, Hayley Tyrer, Joanne Gamble, Emma Murphy, John Archer, Andrew Steven, Mark J Taylor, Joseph D Turner
Filariasis is a global health problem targeted for elimination. Curative drugs (macrofilaricides) are required to accelerate elimination. Candidate macrofilaricides require testing in preclinical models of filariasis. The incidence of infection failures and high intra-group variation means that large group sizes are required for drug testing. Further, a lack of accurate, quantitative adult biomarkers results in protracted timeframes or multiple groups for endpoint analyses. Here we evaluate intra-vital ultrasonography (USG) to identify B...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649225/insulin-receptor-knockdown-blocks-filarial-parasite-development-and-alters-egg-production-in-the-southern-house-mosquito-culex-quinquefasciatus
#2
Andrew Bradley Nuss, Mark R Brown, Upadhyayula Suryanarayana Murty, Monika Gulia-Nuss
Lymphatic filariasis, commonly known as elephantiasis, is a painful and profoundly disfiguring disease. Wuchreria bancrofti (Wb) is responsible for >90% of infections and the remainder are caused by Brugia spp. Mosquitoes of the genera Culex (in urban and semi-urban areas), Anopheles (in rural areas of Africa and elsewhere), and Aedes (in Pacific islands) are the major vectors of W. bancrofti. A preventive chemotherapy called mass drug administration (MDA), including albendazole with ivermectin or diethylcarbamazine citrate (DEC) is used in endemic areas...
April 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29630083/renal-microsporidiosis-in-pediatric-bone-marrow-transplant-recipients-a-case-series
#3
Saloni Shah, Sheba Sweetline Jacob, Rama Mani, Ashok Parameswaran, Sunil Kumar, Rajeev A Annigeri, Raja Mahesh, Ramya Uppuluri
Microsporidiosis is a rare, but emerging opportunistic infection in solid organ transplant and stem cell transplant recipients. Renal involvement in microsporidiosis is very rarely seen in these recipients. We describe two cases of pediatric renal microsporidiosis, diagnosed on renal biopsies, following bone marrow transplantation presenting as severe acute kidney injury. The first patient died, whereas the second survived due to early diagnosis based on high index of suspicion and prompt treatment with Albendazole...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29625098/evaluation-of-kinase-inhibitors-nilotinib-and-everolimus-against-alveolar-echinococcosis-in-vitro-and-in-a-mouse-model
#4
Deborah E Joekel, Britta Lundström-Stadelmann, Beat Müllhaupt, Andrew Hemphill, Peter Deplazes
Infection with the larval stage (metacestode) of the fox tapeworm Echinococcus multilocularis leads to a primary hepatic disease referred to as alveolar echinococcosis (AE). The progressive disease can be lethal if untreated. In cases where complete parasite resection by surgery is not feasible, the current treatment regimens of AE consist of chemotherapy with the parasitostatic benzimidazoles albendazole or mebendazole over decades. Kinase-inhibitors currently administered in various cancer treatments are of increasing interest also as anti-parasitic drugs due to previous promising in vitro results...
April 3, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29616349/in-vitro-and-in-vivo-effects-of-chitosan-praziquantel-and-chitosan-albendazole-nanoparticles-on-echinococcus-granulosus-metacestodes
#5
Negin Torabi, Faramarz Dobakhti, Soghrat Faghihzadeh, Ali Haniloo
Cystic echinococcosis (CE), which is caused by the metacestode of Echinococcus granulosus, is one of the most important zoonoses affecting humans. Benzimidazoles (in particular albendazole) and praziquantel (PZQ) are effective against CE, but poor water solubility of these agents often leads to inadequate results. Here, we evaluate the effects of chitosan-albendazole (ChABZ) and chitosan-praziquantel (ChPZQ) nanoparticles as a new formulation on hydatid cysts both in vitro and in vivo. Developed microcysts in culture were treated with different concentrations of ChABZ and ChPZQ nanoparticles (either alone or in combination), and ABZ + PZQ suspension...
April 3, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29611504/albendazole-treatment-improves-work-capacity-in-women-smallholder-farmers-infected-with-hookworm-a-double-blind-randomized-control-trial
#6
Margaret Salmon, Christian Salmon, Maurice Masoda, Jean-Maurice Salumu, Carmine Bozzi, Phil Nieburg, Lisa M Harrison, Debbie Humphries, Naomi Abaca Uvon, Sarah K Wendel, Clint Trout, Michael Cappello
An estimated 4.7 billion people live in regions exposed to soil-transmitted helminths, intestinal parasites that have significant impacts on the health of women smallholder farmers. The goal of this trial was to determine whether treatment with albendazole impacts the work capacity of these farmers. This is a prospective double-blind, randomized effectiveness trial. Participants ( N = 250) were randomly selected from safe motherhood groups in the Democratic Republic of Congo. Prevalence/intensity of hookworm infection, hemoglobin, and demographics was obtained...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29601575/discovery-of-genomic-intervals-that-underlie-nematode-responses-to-benzimidazoles
#7
Mostafa Zamanian, Daniel E Cook, Stefan Zdraljevic, Shannon C Brady, Daehan Lee, Junho Lee, Erik C Andersen
Parasitic nematodes impose a debilitating health and economic burden across much of the world. Nematode resistance to anthelmintic drugs threatens parasite control efforts in both human and veterinary medicine. Despite this threat, the genetic landscape of potential resistance mechanisms to these critical drugs remains largely unexplored. Here, we exploit natural variation in the model nematodes Caenorhabditis elegans and Caenorhabditis briggsae to discover quantitative trait loci (QTL) that control sensitivity to benzimidazoles widely used in human and animal medicine...
March 30, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29595013/-multidisciplinary-management-of-alveolar-echinococcosis-echino-liege-working-group
#8
A Cambier, J B Giot, P Leonard, N Bletard, P Meunier, R Hustinx, J Delwaide, N Meurisse, P Honore, B Losson, M P Hayette, O Detry
Alveolar echinococcosis is a zoonotic disease due to the tapeworm Echinococcus multilocularis. The definitive host is the red fox. Until recently, Belgium was considered a country at very low risk for alveolar echinococcosis. However, recent studies carried out in southern Belgium have revealed, through post-mortem examination, high prevalences (up to 62 %) in foxes. Cats and dogs can act as definitive hosts. Human are accidentally infected by ingestion of food contaminated by the feces. After a long incubation period, invasive hepatic lesions may appear, as well as extra-hepatic lesions...
March 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29582260/orbital-apex-syndrome-secondary-to-optic-nerve-cysticercosis
#9
Pratik Chaugule, D Ravi Varma, Preeti Patil Chhablani
A 22-year-old male presented to us with complaints of sudden painful loss of vision in left eye 10 days ago along with inward deviation of the left eye. Best-corrected visual acuity (BCVA) in right eye was 20/20 and 20/50 in left eye. Left eye showed limitation of abduction, a relative afferent pupillary defect, normal anterior segment with optic disc oedema. Contrast-enhanced MRI of the brain and orbit showed thickening of left optic nerve along with a cystic lesion near the orbital apex with a central iso- to hyperintense spot resembling a scolex...
March 26, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29579308/the-effect-of-albendazole-treatment-on-non-seizure-outcomes-in-patients-with-symptomatic-neurocysticercosis
#10
Kriti Thapa, Matthew L Romo, Arturo Carpio, Denise Leslie, Howard Andrews, W Allen Hauser, Elizabeth A Kelvin
Background: There is little information about the impact of anthelminthic treatment on clinical symptoms other than seizures in neurocysticercosis (NC). We investigated the effect of albendazole on non-seizure symptoms experienced by patients with NC. Methods: Data are from a randomized controlled trial comparing albendazole plus prednisone with placebo plus prednisone for treatment of NC among 173 patients with active or transitional NC cysts and new-onset symptoms...
March 22, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29560698/albendazole-induced-recurrent-acute-toxic-hepatitis-a-case-report
#11
Yilmaz Bilgic, Cengiz Yilmaz, Yasir Furkan Cagin, Yahya Atayan, Nese Karadag, Murat Muhsin Muhip Harputluoglu
INTRODUCTION: Drug induced acute toxic hepatitis can be idiosyncratic. Albendazole, a widely used broad spectrum antiparasitic drug is generally accepted as a safe drug. It may cause asymptomatic transient liver enzyme abnormalities but acute toxic hepatitis is very rare. Case Report : Herein, we present the case of 47 year old woman with recurrent acute toxic hepatitis after a single intake of albendazole in 2010 and 2014. The patient was presented with symptoms and findings of anorexia, vomiting and jaundice...
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29560642/minimally-invasive-treatment-of-hepatic-hydatid-disease-with-perforator-grinder-aspirator-apparatus-and-follow-up-of-42-patients
#12
I C Sormaz, L Avtan
INTRODUCTION: The gold standard treatment for hydatid cyst (HC) is surgery. In surgical practice, open procedures still remain as the first option but in this minimally-invasive era, the frequency of laparoscopic procedures is increasing. The aim of this study is to evaluate the results of 42 patients with HC who underwent surgery with Perforator-Grinder-Aspirator-Apparatus (PGAA) and demonstrate the success and reliability of this technique. METHODS: The datas of 42 patients, who underwent laparoscopic surgery with PGAA between Jan 2010 and Feb 2016 were evaluated retrospectively...
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29559140/concurrent-treatment-with-a-macrocyclic-lactone-and-benzimidazole-provides-season-long-performance-advantages-in-grazing-cattle-harboring-macrocyclic-lactone-resistant-nematodes
#13
M D Edmonds, A F Vatta, A A Marchiondo, H B Vanimisetti, J D Edmonds
In 2013, a 118-day study was initiated to investigate the efficacy of concurrent treatment at pasture turnout with an injectable macrocyclic lactone with activity up to 28 days and an oral benzimidazole, referred to as "conventional" anthelmintics, when compared to treatment with conventional macrocyclic lactone alone or an injectable macrocyclic lactone with extended activity of 100 days or longer. A group of 210 steers were obtained from a ranch in California and transported to Idaho, USA. A total of 176 steers with the highest fecal egg counts were blocked by pre-treatment body weights and pasture location...
March 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29557502/toxocarosis-in-children-poor-hygiene-habits-and-contact-with-dogs-is-related-to-longer-treatment
#14
Anna Kroten, Kacper Toczylowski, Elzbieta Oldak, Artur Sulik
The objective of this study was to investigate the main clinical signs and symptoms of toxocarosis in children and the treatment results. The study group consisted of 66 seropositive children aged 2 to 16 years, evaluated in an outpatient clinic in north-eastern Poland for 24 months. Male gender and living in urban areas predominated in the study population. Children presented with non-specific symptoms, of which the most common was abdominal pain or tenderness, which was reported by 39 (59%) patients. Absolute eosinophil counts were increased in 32 (48%) children...
March 20, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29543807/association-between-gastrointestinal-tract-infections-and-glycated-hemoglobin-in-school-children-of-poor-neighborhoods-in-port-elizabeth-south-africa
#15
Nan Shwe Nwe Htun, Peter Odermatt, Ivan Müller, Peiling Yap, Peter Steinmann, Christian Schindler, Markus Gerber, Rosa Du Randt, Cheryl Walter, Uwe Pühse, Jürg Utzinger, Nicole Probst-Hensch
BACKGROUND: Low- and middle-income countries are facing a dual disease burden with infectious diseases (e.g., gastrointestinal tract infections) and non-communicable diseases (e.g., diabetes) being common. For instance, chronic parasite infections lead to altered immune regulatory networks, anemia, malnutrition, and diarrhea with an associated shift in the gut microbiome. These can all be pathways of potential relevance for insulin resistance and diabetes. The aim of this study was to investigate the association between common gastrointestinal tract infections and glycemia in children from non-fee paying schools in South Africa...
March 15, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29538222/acute-major-gastrointestinal-bleeding-caused-by-hookworm-infection-in-a-patient-on-warfarin-therapy-a-case-report
#16
Yu Meng, FangGen Lu, Lin Shi, MeiChu Cheng, Jie Zhang
RATIONALE: The use of anticoagulants is a contributor to gastrointestinal (GI) bleeding. Most bleeding patients on anticoagulant therapy such as warfarin commonly have basic lesions existing in their GI mucosa. PATIENT CONCERNS: We report a case of major GI bleeding following the use of anticoagulants in a patient with hookworm infection. DIAGNOSES: The patient was diagnosed with nephrotic syndrome with pulmonary embolism. INTERVENTIONS: He was treated with anticoagulants and suffered from acute major GI bleeding during the treatment...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29538198/alveolar-echinococcosis-in-the-head-of-pancreas-a-case-report
#17
Rong-Xing Zhou, Hai-Jie Hu, Wen-Jie Ma, Yong Jiang, Fu-Yu Li
RATIONALE: Pancreatic alveolar echinococcosis (AE) is an exceptionally rare disease; no more than 10 cases have been published to date. It is characterized as extensive local tissue infringement and destruction; thus, extended surgical resection, such as duodenopancreatectomy, is often needed to obtain a negative resection margin so as to improve the long-term outcome and prognosis. PATIENT CONCERNS: A middle-aged Tibetan man was admitted due to a 16-year history of recurrent pain in the right upper abdomen...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29532768/impact-of-four-years-of-annual-mass-drug-administration-on-prevalence-and-intensity-of-schistosomiasis-among-primary-and-high-school-children-in-western-kenya-a-repeated-cross-sectional-study
#18
Bernard O Abudho, Eric M Ndombi, Bernard Guya, Jennifer M Carter, Diana K Riner, Nupur Kittur, Diana M S Karanja, W Evan Secor, Daniel G Colley
Schistosomiasis remains a major public health problem in Kenya. The World Health Organization recommends preventive chemotherapy with praziquantel (PZQ) to control morbidity due to schistosomiasis. Morbidity is considered linked to intensity of infection, which along with prevalence is used to determine the frequency of mass drug administration (MDA) to school-age children. We determined the impact of annual school-based MDA on children across all primary and high school years using a repeated cross-sectional study design in five schools near Lake Victoria in western Kenya, an area endemic for Schistosoma mansoni ...
March 12, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29529254/a-new-scope-for-orlistat-effect-of-approved-anti-obesity-drug-against-experimental-microsporidiosis
#19
I F Abou-El-Naga, D E Said, M R Gaafar, S M Ahmed, S A El-Deeb
As the current therapies for intestinal microsporidiosis are either inconsistent in their efficacies or hampered by several adverse effects, alternative antimicrosporidial agents are being sought. The present study is the first that was designed to evaluate the potency of orlistat, an approved anti-obesity drug, against intestinal microsporidiosis caused by both Enterocytozoon bieneusi and Encephalitozoon intestinalis. Results were assessed through studying fecal and intestinal spore load, intestinal histopathological changes, viability, and infectivity of spores from treated animals...
February 24, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29522097/surgical-overview-of-cardiac-echinococcosis-a-rare-entity
#20
Vivek Wadhawa, Jigar Shah, Chirag Doshi, Jaydip Ramani, Ketav Lakhia, Divyesh Rathod, Reema Tavar, Jignesh Kothari
OBJECTIVES: The purpose of this study was to describe our experience with the presentation and management of cardiac echinococcosis and the outcomes. METHODS: We performed a retrospective study from January 2012 to September 2017 in 10 patients operated on for cardiac echinococcosis. There were 6 men and 4 women; the age range was 17-55 years (mean age, 35.9 ± 12.04 years). Among the 10 patients, 3 had multiple cysts and of the 7 patients with a solitary cyst, 5 cysts were in the left ventricle, 1 was in the right ventricle and 1 was in the interventricular septum...
March 7, 2018: Interactive Cardiovascular and Thoracic Surgery
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