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https://www.readbyqxmd.com/read/28821422/adhesion-molecules-chemokines-and-matrix-metallo-proteinases-response-after-albendazole-and-albendazole-plus-steroid-therapy-in-swine-neurocysticercosis
#1
Satyendra K Singh, Kashi N Prasad, Aloukick K Singh, Kamlesh K Gupta, Amrita Singh, Mukesh Tripathi, Rakesh K Gupta
The treatment of neurocysticercosis (NCC) varies with location, number and stage of the Taenia solium cysticerci (cysts). Albendazole (ABZ) effectively kills cysticerci, and subsequently induces neuro-inflammation facilitated by leukocyte infiltration. We hypothesize that immune response varies around drug responder (degenerating/dying) and non-responder (viable) cysts after ABZ and ABZ plus steroid (ABZS) therapy, which may determine the disease pathogenesis. Twenty cysticercotic swine were treated with ABZ (n = 10; group1) and ABZS (n = 10; group2)...
August 15, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28820693/clinical-features-of-intermittent-migratory-swelling-caused-by-gnathostomiasis-with-complete-follow-up
#2
Chollasap Sharma, Watcharapong Piyaphanee, Dorn Watthanakulpanich
A 15-year-old Thai girl was referred to the Hospital for Tropical Diseases of Mahidol University with a 3-week history of an intermittent migratory mass on the forehead. She was diagnosed with cutaneous gnathostomiasis. The patient was treated with albendazoleat 400 mg orally twice a day for 3 weeks, with good compliance. She revisited the hospital after 3 months and was seen to have been unresponsive to the initial treatment. There was intermittent swelling in her right upper eyelid along with mild redness around her right upper and lower eyelids...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28819487/an-evaluation-of-wb123-antibody-elisa-in-individuals-treated-with-ivermectin-and-albendazole-and-implementation-challenges-in-africa
#3
Dziedzom Komi de Souza, Irene Offei Owusu, Joseph Otchere, Michelle Adimazoya, Kwadwo Frempong, Collins Stephen Ahorlu, Daniel Adjei Boakye, Michael David Wilson
The development of antibody testing for the diagnosis of lymphatic filariasis (LF) is intended to enhance the monitoring and evaluation activities of the Global Program for the Elimination of LF. This is due to the fact that antibody tests are expected to be the most sensitive at detecting exposure to LF compared to antigen that takes longer to develop. To this end a new antibody-based enzyme linked immunosorbent assay (ELISA) to Wuchereria bancrofti antigen Wb123 has been developed and further designed into a point of care rapid diagnostic test, under evaluation...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28807628/vertebral-alveolar-echinococcosis-a-case-report-systematic-analysis-and-review-of-the-literature
#4
REVIEW
Thomas Raphael Meinel, Bruno Gottstein, Vanessa Geib, Marius Johann Keel, Ruggero Biral, Markus Mohaupt, Jan Brügger
Alveolar echinococcosis caused by Echinococcus multilocularis is an infrequent zoonosis with a high degree of disability, morbidity, and mortality, especially in disease clusters of the northern hemisphere. The diagnosis is complicated by extended incubation time, diverse clinical manifestations, and mimicking of differential diagnoses. The primary organ affected is the liver, but extrahepatic disease is possible, with vertebral involvement in only a few dozen cases described worldwide. Although vertebral alveolar echinococcosis seems to be rare, it might be under diagnosed, and it might be seen more often as the number of people with immunocompromised conditions increases...
August 11, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28807278/helminth-infections-on-organic-dairy-farms-in-spain
#5
I Orjales, M Mezo, M Miranda, M González-Warleta, F Rey-Crespo, M Vaarst, S Thamsborg, F J Diéguez, J A Castro-Hermida, M López-Alonso
The aim of this study was to assess the prevalence of the major helminth infections affecting organic dairy cattle in northern Spain. Milk and faecal samples were obtained from 443 milking cows. Ostertagia ostertargi and Fasciola hepatica exposure was assessed by detection of specific antibodies in milk samples and F. hepatica infection was diagnosed by the detection of coproantigens in faecal samples. Dictyocaulus viviparus and Calicophoron daubneyi infections were diagnosed by conventional coprological techniques...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28806951/phytochemical-analysis-and-in-vitro-anthelmintic-activity-of-lophira-lanceolata-ochnaceae-on-the-bovine-parasite-onchocerca-ochengi-and-on-drug-resistant-strains-of-the-free-living-nematode-caenorhabditis-elegans
#6
Justin Kalmobé, Dieudonné Ndjonka, Djafsia Boursou, Jacqueline Dikti Vildina, Eva Liebau
BACKGROUND: Onchocerciasis is one of the tropical neglected diseases (NTDs) caused by the nematode Onchocerca volvulus. Control strategies currently in use rely on mass administration of ivermectin, which has marked activity against microfilariae. Furthermore, the development of resistance to ivermectin was observed. Since vaccine and safe macrofilaricidal treatment against onchocerciasis are still lacking, there is an urgent need to discover novel drugs. This study was undertaken to investigate the anthelmintic activity of Lophira lanceolata on the cattle parasite Onchocerca ochengi and the anthelmintic drug resistant strains of the free living nematode Caenorhabditis elegans and to determine the phytochemical profiles of the extracts and fractions of the plants...
August 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28794687/prevalence-and-risk-factors-associated-with-lymphatic-filariasis-in-american-samoa-after-mass-drug-administration
#7
Shaun P Coutts, Jonathan D King, Molisamoa Pa'au, Saipale Fuimaono, Joseph Roth, Mary Rose King, Patrick J Lammie, Colleen L Lau, Patricia M Graves
BACKGROUND: In 2000, American Samoa had 16.5% prevalence of lymphatic filariasis (LF) antigenemia. Annual mass drug administration (MDA) was conducted using single-dose albendazole plus diethylcarbamazine from 2000 to 2006. This study presents the results of a 2007 population-based PacELF C-survey in all ages and compares the adult filarial antigenemia results of this survey to those of a subsequent 2010 survey in adults with the aim of improving understanding of LF transmission after MDA...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28779899/effects-of-selected-indonesian-plant-extracts-on-e-%C3%A2-cuniculi-infection-in%C3%A2-vivo
#8
Bohumil Sak, Anna Jandová, Karel Doležal, Martin Kváč, Dana Květoňová, Lenka Hlásková, Michael Rost, Milan Olšanský, Wisnu Nurcahyo, Ivona Foitová
The present study was conducted to evaluate the methanolic extracts from several plant leaves widely used in traditional medicine to cure digestive tract disorders and in the self-medication of wild animals such as non-human primates, namely Archidendron fagifolium, Diospyros sumatrana, Shorea sumatrana, and Piper betle leaves, with regard to their antimicrosporidial activity against Encephalitozoon cuniculi in immunocompetent BALB/c mice determined using molecular detection of microsporidial DNA (qPCR) in various tissues and body fluids of infected, treated mice...
August 2, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28761493/gluteal-hydatid-cyst-report-of-a-case-from-iran
#9
Behzad Nemati Hona, Farbod Emami Yeganeh
Hydatid cyst involves both hard and soft tissues even without the evidence of the disease in liver or lungs; however, this manifestation is very rare, particularly in musculoskeletal regions). The current report describes a case with primary diagnose of cystic gluteal swelling leading to diagnose of hydatid cyst after surgical exploration in an 80-yr-old woman the Surgical Outpatient Department, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. During surgery, the cavity was washed by silver nitrate and the cyst content was appropriately evacuated...
April 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761478/m-rna-gene-expression-of-inf-%C3%AE-and-il-10-during-intestinal-phase-of-trichinella-spiralis-after-myrrh-and-albendazole-treatment
#10
Hanaa Y Bakir, Rasha Ah Attia, Abeer E Mahmoud, Zedan Ibraheim
BACKGROUND: The protective response developed against Trichinella spiralis infection provokes immune and inflammatory responses mediated by cytokines released from T helper cells. We aimed to evaluate the effect of albendazole or myrrh on the expression of IFN-γ and IL-10 in BALB/c mice infected with T. spiralis. METHODS: This study was done at the Animal House of Faculty of Medicine, Assiut University (Assiut, Egypt) from April to December 2015. Mice were infected with 300 T...
April 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761236/primary-renal-echinococcosis
#11
Vishal V Ramteke, Nishant S Deshpande, Manish R Balwani, Charulata P Bawankule
Echinococcosis is a parasitic infection caused by the larval stage of a cestode Echinococcus granulosus and is endemic in sheep farming regions of developing countries. It manifests as hydatid cyst and most commonly is found in liver followed by lungs. Renal hydatid cyst is rare and amounts for 2% of all cases. There are no specific clinical manifestations, and hence diagnosis of renal hydatid disease is missed out easily without imaging. We report a case of 50-year-old female who had 6 months history of lower abdominal pain with hematuria, found to have right renal hydatid cyst on imaging which was treated with right nephrectomy with pre- and post-operative albendazole treatment...
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28760057/foetal-outcomes-after-exposure-to-albendazole-in-early-pregnancy
#12
June-Seek Choi, Jung-Yeol Han, Hyun-Kyong Ahn, Hyun-Mee Ryu, Gideon Koren
No abstract text is available yet for this article.
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28754237/treatment-of-larva-migrans-syndrome-with-long-term-administration-of-albendazole
#13
Amy Hombu, Ayako Yoshida, Taisei Kikuchi, Eiji Nagayasu, Mika Kuroki, Haruhiko Maruyama
BACKGROUND: Larva migrans syndrome is a food-borne parasitic disease in humans, caused by accidental ingestion of eggs or larvae of ascarid nematodes, namely, Toxocara canis, Toxocara cati, or Ascaris suum, the roundworms commonly found in the intestines of dogs, cats and pigs respectively. When a patient is diagnosed as having larva migrans syndrome, oral-administration of albendazole is recommended, however, the regimen remains controversial worldwide. In Japan, the duration of albendazole administration is longer than those of European and North American countries...
July 14, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28749759/criteria-to-stop-mass-drug-administration-for-lymphatic-filariasis-have-been-achieved-throughout-plateau-and-nasarawa-states-nigeria
#14
Abel Eigege, Darin S Evans, Gregory S Noland, Emmanuel Davies, John Umaru, Solomon E Adelamo, Bulus Mancha, Jonathan D King, Emmanuel S Miri, Bridget Okoeguale, Emily P Griswold, Frank O Richards
Nigeria has the largest population at risk for lymphatic filariasis (LF) in Africa. This study used a transmission assessment survey (TAS) to determine whether mass drug administration (MDA) for LF could stop in 21 districts, divided into four evaluation units (EUs), of Plateau and Nasarawa States, Nigeria, after 8-12 years of annual albendazole-ivermectin treatment. A total of 7,131 first- and second-year primary school children (approximately 6-7 years old) were tested for LF antigen by immunochromatographic test (ICT) from May to June 2012...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28747414/muscular-sarcocystosis-an-index-case-in-a-native-malaysian
#15
Nurashikin Mohammad, Alwi Muhd Besari, Pradeep Kumar Nair, Wan Syamimee Wan Ghazali
A previously healthy 20-year-old man presented with prolonged intermittent low grade fever and cough for 6months. He had bilateral calf pain and lower limb weakness 2days prior to admission. Physical examination revealed multiple enlarged lymph nodes with hepatomegaly. There was bilateral calf tenderness with evidence of proximal myopathy. Full blood picture showed lymphocytosis with reactive lymphocytes and eosinophilia. Creatine kinase and lactate dehydrogenase were markedly elevated. Over 2 weeks of admission, patient was treated symptomatically until the muscle biopsy of right calf revealed eosinophilic myositis with muscular sarcocystosis...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28741923/co-delivery-of-trichosanthin-and-albendazole-by-nano-self-assembly-for-overcoming-tumor-multidrug-resistance-and-metastasis
#16
Yisi Tang, Jianming Liang, Aihua Wu, Yingzhi Chen, Pengfei Zhao, Tingting Lin, Meng Zhang, Qin Xu, Jianxin Wang, Yongzhuo Huang
Multidrug resistance (MDR) and metastasis are the major obstacles in cancer chemotherapy. Nanotechnology-based combination therapy is a useful strategy. Recently, the combination of biologics and small drugs has attracted much attention in cancer therapy. Yet, the treatment outcomes are often compromised by the different pharmacokinetic profiles of the co-administered drugs thus leading to inconsistent drug uptake and suboptimal drug combination at the tumor sites. Nanotechnology-based co-delivery offers a promising method to address this problem, which is well demonstrated in the use of small drug combinations...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28727331/-toxocariasis-a-neglected-disease-in-switzerland
#17
Amélie Duréault, Carlos Perez Valdes, Lalensia Weber, Adam Ogna, Christine Sempoux, Oriol Manuel, Julie Delaloye
Toxocariasis is a zoonotic disease that occurs when humans are infected by the parasites Toxocara canis or Toxocara cati. Toxocariasis is highly prevalent in tropical areas, but can also be found in industrialized countries, particularly in rural areas. Clinical presentation can range from asymptomatic infection to more severe disease. Diagnosis of toxocariasis is based on suggestive clinical findings, eosinophilia and a positive serological testing. Albendazole represents the first-line treatment, associated with corticosteroids in case of severe disease...
April 12, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28723904/impact-of-mass-drug-administration-for-elimination-of-lymphatic-filariasis-in-nepal
#18
Chet Raj Ojha, Basant Joshi, Khagendra Prakash Kc, Shyam Prakash Dumre, Keshav Kumar Yogi, Bandana Bhatta, Tulasi Adhikari, Kathryn Crowley, Babu Ram Marasini
BACKGROUND: Lymphatic filariasis (LF) is a neglected tropical disease transmitted by mosquitoes. Nepal has implemented a national effort to eliminate LF by 2020 through mass drug administration (MDA) using diethylcarbamazine (DEC) and albendazole (ALB). We assessed the impact of MDAs on LF in selected districts of Nepal after the recommended six MDA rounds had been completed. METHODOLOGY AND PRINCIPAL FINDINGS: Baseline surveys were conducted in seven districts and mapping data were used as baseline in the other three districts before starting MDA in 2009...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28723333/enhanced-prophylaxis-plus-antiretroviral-therapy-for-advanced-hiv-infection-in-africa
#19
RANDOMIZED CONTROLLED TRIAL
James Hakim, Victor Musiime, Alex J Szubert, Jane Mallewa, Abraham Siika, Clara Agutu, Simon Walker, Sarah L Pett, Mutsa Bwakura-Dangarembizi, Abbas Lugemwa, Symon Kaunda, Mercy Karoney, Godfrey Musoro, Sheila Kabahenda, Kusum Nathoo, Kathryn Maitland, Anna Griffiths, Margaret J Thomason, Cissy Kityo, Peter Mugyenyi, Andrew J Prendergast, A Sarah Walker, Diana M Gibb
BACKGROUND: In sub-Saharan Africa, among patients with advanced human immunodeficiency virus (HIV) infection, the rate of death from infection (including tuberculosis and cryptococcus) shortly after the initiation of antiretroviral therapy (ART) is approximately 10%. METHODS: In this factorial open-label trial conducted in Uganda, Zimbabwe, Malawi, and Kenya, we enrolled HIV-infected adults and children 5 years of age or older who had not received previous ART and were starting ART with a CD4+ count of fewer than 100 cells per cubic millimeter...
July 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28711534/primary-intradural-extramedullary-cervical-spinal-cysticercosis
#20
Vetrivel Muralidharan, Bijesh Ravindran Nair, Bimal Patel, Vedantam Rajshekhar
BACKGROUND: Spinal cysticercosis has been reported in 0.7%-3.0% of patients with neurocysticercosis. Most patients with spinal cysticercosis have a coexisting intracranial disease. Most often this intracranial disease manifests as intradural extramedullary lesions involving thoracic and lumbar regions or intramedullary lesions. Intradural extramedullary primary spinal cysticercosis manifesting as cervical myelopathy is extremely rare and has not been reported to date. CASE DESCRIPTION: A 56-year-old man from the northeastern part of India presented with progressive spastic quadriparesis...
July 12, 2017: World Neurosurgery
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