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https://www.readbyqxmd.com/read/29432423/estimation-of-the-number-of-women-of-reproductive-age-in-need-of-preventive-chemotherapy-for-soil-transmitted-helminth-infections
#1
Denise Mupfasoni, Alexei Mikhailov, Pamela Mbabazi, Jonathan King, Theresa W Gyorkos, Antonio Montresor
BACKGROUND: Soil-transmitted helminth infections are among the most common infections in developing countries. Globally, as many as 2 billion people are considered to be at risk for soil-transmitted-helminth (STH) infections. Preschool children (PSAC), school-age children (SAC) and women of reproductive age (WRA) are at high risk of STH-attributable morbidity and preventive chemotherapy (PC) for STH is recommended by the World health Organization (WHO). METHODOLOGY/PRINCIPAL FINDINGS: Over the last five years, PC coverage in PSAC and SAC has gradually increased, while coverage in WRA has lagged...
February 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29426481/albendazole-nanocrystals-in-experimental-alveolar-echinococcosis-enhanced-chemoprophylactic-and-clinical-efficacy-in-infected-mice
#2
Patricia Pensel, Alejandro Paredes, Clara M Albani, Daniel Allemandi, Sergio Sanchez Bruni, Santiago D Palma, María C Elissondo
Human alveolar echinococcosis is caused by the fox tapeworm Echinococcus multilocularis and is usually fatal if left untreated. Medical treatment with albendazole (ABZ) remains an effective option. However, due to its low aqueous solubility, ABZ is poorly and erratically absorbed following oral administration resulting in low drug levels in plasma and liver distribution. Thus, there arises the need to find a simple, efficient and scalable method to produce new ABZ formulations with increased bioavailability...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29426477/the-effect-on-liveweight-gain-of-using-anthelmintics-with-incomplete-efficacy-against-resistant-cooperia-oncophora-in-cattle
#3
Paul M Candy, Tania S Waghorn, Chris M Miller, Siva Ganesh, Dave M Leathwick
A replicated field trial was conducted to measure the effect on liveweight gain of failing to adequately control anthelmintic resistant populations of Cooperia oncophora and to determine whether populations, and hence production losses, increased with time. Eight mobs of 10 Friesian-Hereford calves were run on independent farmlets from January to December, over each of two years. All mobs were routinely treated with a pour-on formulation of eprinomectin every six weeks, which controlled parasites other than Cooperia...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29420245/imported-gnathostomiasis-manifesting-as-cutaneous-larva-migrans-and-l%C3%A3-ffler-s-syndrome
#4
William L Hamilton, Daniel Agranoff
Here, we report an unusual case of invasive gnathostomiasis in a returning traveller, with a shifting pattern of relapsing cutaneous disease. The previously fit and well 32-year-old man first presented with serpiginous, pruriginous erythematous tracks characteristic of cutaneous larva migrans shortly after returning from South-East Asia. He was systemically well with no other symptoms. After ivermectin therapy, he re-presented with respiratory symptoms, peripheral eosinophilia and transient pulmonary infiltrates; the classic triad of Löffler's syndrome associated with invasive helminth infection...
February 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29414120/evaluation-of-the-anthelminthic-potential-of-duranta-erecta-l-verbenaceae-fruits-used-in-nigerian-ethnomedicine-as-a-vermifuge
#5
Munachimso Ihuoma Udobi, Terry Adaeze Nzeakor, Ifeanyi Gabriel Eke, Ikenna Onyema Ezeh, Amaechi Onyeabor, Idika Kalu Idika, Chukwunyere Okwudiri Nwosu
ETHNOPHARMACOLOGICAL RELEVANCE: Duranta erecta L. fruits have been reported to have in vitro anthelminthic properties. People living in the tropical South-Eastern part of Nigeria use the plant in folk medicine for the treatment of malaria, abscesses and as a vermifuge. Although there are a few reports about its in vitro anthelminthic activity against different worm categories, scientific reports regarding its in vivo anthelminthic activity are limited. AIM OF THE STUDY: This study was designed with the aim of determining the potential of the plant as an anthelminthic and to verify the claims made by its local users...
January 29, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29414108/the-optimal-timing-of-post-treatment-sampling-for-the-assessment-of-anthelminthic-drug-efficacy-against-ascaris-infections-in-humans
#6
Bruno Levecke, Alice V Easton, Piet Cools, Marco Albonico, Shaali Ame, John S Gilleard, Jennifer Keiser, Antonio Montresor, Roger Prichard, Johnny Vlaminck, Jozef Vercruysse
The egg reduction rate (ERR) is the current standard mean to assess the efficacy of drugs against human soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura and hookworm). Although the timing of post-treatment sampling is pivotal for a readily interpretation of drug efficacy, there is lack empirical data that allows recommending the optimal time point for a follow-up egg counting. In the present study, we re-analyzed both the kinetics of worm expulsion and egg output for Ascaris lumbricoides following a single oral dose of albendazole in a series of studies previously conducted in Kenyan communities...
January 13, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29414106/metabolism-of-albendazole-ricobendazole-and-flubendazole-in-haemonchus-contortus-adults-sex-differences-resistance-related-differences-and-the-identification-of-new-metabolites
#7
Lucie Raisová Stuchlíková, Petra Matoušková, Ivan Vokřál, Jiří Lamka, Barbora Szotáková, Anna Sečkařová, Diana Dimunová, Linh Thuy Nguyen, Marián Várady, Lenka Skálová
Haemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite found in small ruminants, has a great ability to develop resistance to anthelmintic drugs. We studied the biotransformation of the three benzimidazole anthelmintics: albendazole (ABZ), ricobendazole (albendazole S-oxide; RCB) and flubendazole (FLU) in females and males of H. contortus in both a susceptible ISE strain and resistant IRE strain. The ex vivo cultivation of living nematodes in culture medium with or without the anthelmintics was used...
January 27, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29412014/albendazole-solution-formulation-via-vesicle-to-micelle-transition-of-phospholipid-surfactant-aggregates
#8
Zahari Vinarov, G Gancheva, V Katev, S Tcholakova
OBJECTIVE: To reveal the physicochemical mechanisms governing the solubilization of albendazole in surfactant and phospholipid-surfactant solutions and, on this basis, to formulate clinically-relevant dose of albendazole in solution suitable for parenteral delivery. SIGNIFICANCE: (1) A new drug delivery system for parenteral delivery of albendazole is proposed, offering high drug solubility and low toxicity of the materials used; (2) New insights on the role of surface curvature on albendazole solubilization in surfactant and surfactant-phospholipid aggregates are provided...
February 7, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29402636/elimination-of-lymphatic-filariasis-in-west-african-urban-areas-is-implementation-of-mass-drug-administration-necessary
#9
REVIEW
Benjamin G Koudou, Dziedzom K de Souza, Nana-Kwadwo Biritwum, Roland Bougma, Meite Aboulaye, Elizabeth Elhassan, Simon Bush, David H Molyneux
Lymphatic filariasis in Africa is caused by the parasite Wuchereria bancrofti and remains a major cause of morbidity and disability in 74 countries globally. A key strategy of the Global Programme for the Elimination of Lymphatic Filariasis, which has a target elimination date of 2020, is the treatment of entire endemic communities through mass drug administration of albendazole in combination with either ivermectin or diethylcarbamazine. Although the strategy of mass drug administration in combination with other interventions, such as vector control, has led to elimination of the infection and its transmission in many rural communities, urban areas in west Africa present specific challenges to achieving the 2020 targets...
February 2, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29386158/albendazole-in-the-treatment-of-hymenolepiasis-in-school-children
#10
Wali Khan, Jahangir Khan, Azizur Rahman, Hamid Ullah, Mohammad Salim, Mudassar Iqbal, Israr Khan, Muhammad Salman, Bakht Munir
Hymenolepiasis is a helminthic and occasionally fatal disease of human imposing heavy economic losses to human society. Present study was aimed to diagnose the school children for the prevalence and control of Hymenolepiasis. A school based cross-sectional analysis of stool samples collected from 188 children aged 06-15 years was carried out (February to June 2016). Two stool samples were collected from each student before diagnosing and after treatment. The samples were fixed in 10% formalin and observed under the light microscope using the methods of direct smear in Lugol's solution, normal saline and flotation techniques...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29383316/solitary-head-and-neck-cysticercosis-a-series-of-rare-cases
#11
Priyanko Chakraborty, Rakhi Kumari, Rajiv-Kumar Jain, Vikash Prasad, Sidharth Pradhan, Purnima Joshi
Introduction: Cysticercosis is a disease which is caused by the infestation of the larvae Taenia solium, with humans acting as an intermediate host instead of a definitive host. Head and neck involvement including maxillofacial and oral involvement of cysticercosis is quite rare. Case Report: We report a series of rare cases of cysticercosis of the head and neck region encountered in a tertiary hospital in Northern India with a brief review of literature and its diagnosis and management...
November 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29382363/identifying-co-endemic-areas-for-major-filarial-infections-in-sub-saharan-africa-seeking-synergies-and-preventing-severe-adverse-events-during-mass-drug-administration-campaigns
#12
Jorge Cano, Maria-Gloria Basáñez, Simon J O'Hanlon, Afework H Tekle, Samuel Wanji, Honorat G Zouré, Maria P Rebollo, Rachel L Pullan
BACKGROUND: Onchocerciasis and lymphatic filariasis (LF) are major filarial infections targeted for elimination in most endemic sub-Saharan Africa (SSA) countries by 2020/2025. The current control strategies are built upon community-directed mass administration of ivermectin (CDTI) for onchocerciasis, and ivermectin plus albendazole for LF, with evidence pointing towards the potential for novel drug regimens. When distributing microfilaricides however, considerable care is needed to minimise the risk of severe adverse events (SAEs) in areas that are co-endemic for onchocerciasis or LF and loiasis...
January 31, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29378542/interrupting-seasonal-transmission-of-schistosoma-haematobium-and-control-of-soil-transmitted-helminthiasis-in-northern-and-central-c%C3%A3-te-d-ivoire-a-score-study-protocol
#13
Yves-Nathan T Tian-Bi, Mamadou Ouattara, Stefanie Knopp, Jean T Coulibaly, Eveline Hürlimann, Bonnie Webster, Fiona Allan, David Rollinson, Aboulaye Meïté, Nana R Diakité, Cyrille K Konan, Eliézer K N'Goran, Jürg Utzinger
BACKGROUND: To achieve a world free of schistosomiasis, the objective is to scale up control and elimination efforts in all endemic countries. Where interruption of transmission is considered feasible, countries are encouraged to implement a comprehensive intervention package, including preventive chemotherapy, information, education and communication (IEC), water, sanitation and hygiene (WASH), and snail control. In northern and central Côte d'Ivoire, transmission of Schistosoma haematobium is seasonal and elimination might be achieved...
January 29, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29368659/pleiotropic-alterations-in-gene-expression-in-latin-american-fasciola-hepatica-isolates-with-different-susceptibility-to-drugs
#14
Santiago Radio, Santiago Fontenla, Victoria Solana, Anna C Matos Salim, Flávio Marcos Gomes Araújo, Pedro Ortiz, Cristian Hoban, Estefan Miranda, Valeria Gayo, Fabiano Sviatopolk-Mirsky Pais, Hugo Solana, Guilherme Oliveira, Pablo Smircich, José F Tort
BACKGROUND: Fasciola hepatica is the main agent of fasciolosis, a zoonotic disease affecting livestock worldwide, and an emerging food-borne disease in humans. Even when effective treatments are available, drugs are costly and can result in tolerance, liver damage and normally they do not prevent reinfection. Drug-resistant strains in livestock have been reported in various countries and, more worryingly, drug resistance in human cases has emerged in South America. The present study aims to characterize the transcriptome of two South American resistant isolates, the Cajamarca isolate from Peru, resistant to both triclabendazole and albendazole (TCBZR/ABZR) and the Rubino isolate from Uruguay, resistant to ABZ (TCBZS/ABZR), and compare them to a sensitive strain (Cenapa, Mexico, TCBZS/ABZS) to reveal putative molecular mechanisms leading to drug resistance...
January 24, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29368624/efficacy-of-ursolic-acid-against-echinococcus-granulosus-in-vitro-and-in-a-murine-infection-model
#15
Jianhai Yin, Congshan Liu, Yujuan Shen, Haobing Zhang, Jianping Cao
BACKGROUND: Cystic echinococcosis is a global public health problem; however, the drugs (albendazole and mebendazole) currently recommended by WHO for its treatment, have limited efficacy. Therefore, novel drugs are required to provide more choices for the treatment of this disease. METHODS: The anthelmintic effects of ursolic acid (UA) were tested on Echinococcus granulosus protoscoleces, germinal cells and metacestodes in vitro. The in vivo efficacy of UA was investigated in mice following secondary infection with E...
January 24, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29352912/synthesis-of-a-poly-ester-dendritic-%C3%AE-cyclodextrin-derivative-by-click-chemistry-combining-the-best-of-two-worlds-for-complexation-enhancement
#16
Luis José López-Méndez, Israel González-Méndez, Rodrigo Aguayo-Ortiz, Laura Dominguez, Sofía L Alcaraz-Estrada, Yareli Rojas-Aguirre, Patricia Guadarrama
In spite of the progress in the cyclodextrins chemistry, the synthesis of monodisperse derivatives with a defined degree of substitution is still a challenge. In this work we present a novel dendritic material produced by combining βCD and second generation poly(ester) dendrons. The selective attachment of dendrons in the seven positions of the βCD-primary face was performed through a CuAAC click reaction, which along with a very simple work-up, allowed obtaining the monodisperse material in very high yields...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29346385/combined-effectiveness-of-anthelmintic-chemotherapy-and-wash-among-hiv-infected-adults
#17
Arianna R Means, Lisette van Lieshout, Eric Brienen, Krista Yuhas, James P Hughes, Paul Ndungu, Benson Singa, Judd L Walson
INTRODUCTION: Current global helminth control guidelines focus on regular deworming of targeted populations for morbidity control. However, water, sanitation, and hygiene (WASH) interventions may also be important for reducing helminth transmission. We evaluated the impact of different potential helminth protective packages on infection prevalence, including repeated treatment with albendazole and praziquantel with and without WASH access. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cohort study nested within a randomized trial of empiric deworming of HIV-infected adults in Kenya...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346367/assessment-of-serum-pharmacokinetics-and-urinary-excretion-of-albendazole-and-its-metabolites-in-human-volunteers
#18
Laura Ceballos, Alejandro Krolewiecki, Marisa Juárez, Laura Moreno, Fabian Schaer, Luis I Alvarez, Rubén Cimino, Judd Walson, Carlos E Lanusse
BACKGROUND: Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of these infections through mass drug administration (MDA) using albendazole (ABZ) or mebendazole. Despite major reductions in STH associated morbidity globally, not all programs have demonstrated the expected impact on prevalence of parasite infections. These therapeutic failures may be related to poor programmatic coverage, suboptimal adherence or the exposure of parasites to sub-therapeutic drug concentrations...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29329012/oxidative-transformation-kinetics-and-pathways-of-albendazole-from-reactions-with-manganese-dioxide
#19
Sin-Yi Liou, Wan-Ru Chen
Albendazole (ABZ) is a benzimidazole-based veterinary anthelmintic used extensively in the treatment of intestinal parasites. Due to its high hydrophobicity, ABZ tends to accumulate in soils and sediments in the environment. This study aims to investigate ABZ's possible degradation by manganese oxides. Minor effects from ionic strength and metal cations on ABZ degradation were observed. By contrast, decrease of pH greatly enhanced the reaction rate. Surface complexation between ABZ and MnO2 was indicated to be the dominant control in the reaction kinetics...
December 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29327323/inclusion-complex-and-nanoclusters-of-cyclodextrin-to-increase-the-solubility-and-efficacy-of-albendazole
#20
P A Pacheco, L N C Rodrigues, J F S Ferreira, A C P Gomes, C J Veríssimo, H Louvandini, R L D Costa, L M Katiki
Albendazole (ABZ), a benzimidazole widely used to control gastrointestinal parasites, is poorly soluble in water, resulting in variable and incomplete bioavailability. This has favored the appearance ABZ-resistant nematodes and, consequently, an increase in its clinical ineffectiveness. Among the pharmaceutical techniques developed to increase drug efficacy, cyclodextrins (CDs) and other polymers have been extensively used with water-insoluble pharmaceutical drugs to increase their solubility and availability...
January 11, 2018: Parasitology Research
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