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https://www.readbyqxmd.com/read/29050898/sushi-cervice-and-gnathostomiasis-a-case-report-and-review-of-imported-infections
#1
REVIEW
Jordan Leroy, Marjorie Cornu, Anne Sophie Deleplancque, Séverine Loridant, Emmanuel Dutoit, Boualem Sendid
We describe a case of imported cutaneous gnathostomiasis in a Thai patient living in France. Gnathostomiasis is a zoonosis of food origin. The disease is endemic in Southeast Asia and Latin America. However, over the past 30 years, an increasing number of imported cases has been described in Europe and America. The disease is rare in Western Europe and the majority of cases described had a cutaneous clinical presentation. The disease may sometimes be confused with allergy, leading to a delay in diagnosis. Visceral symptoms are rare but may follow severe attacks...
October 16, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29049181/recurrent-multiple-organ-involvement-of-disseminated-alveolar-echinococcosis-in-3-patients-case-report
#2
Leilei Xu, Sikandaer Siyiti, Xinghua Song, Hao Wen, Liwen Ding, Akbar Yunus, Zheng Tian, Chong Wang, Jiangtao Chen
RATIONALE: Alveolar echinococcosis (AE) is a rare but highly malignant form of echinococcosis caused by Echinococcus multilocularis. There have been very few reports on multiple-organ AE, especially AE in bones. Here we report 3 rare cases of disseminated multiple-organ AE from western China and its neighboring areas. PATIENT CONCERNS: Patient 1 had back and left hip pain, headache, and weakness in left lower limb, often with minor epilepsy and fluctuation of blood pressure...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048588/bertiella-studeri-infection-a-rare-cause-of-chronic-abdominal-pain-in-a-child-from-north-india
#3
Shruti Sharma, Jagadeesh Menon, Sadhna Lal, Babu Ram Thapa
Bertiella is a common parasite seen in non-human primates. It is rarely seen in humans. We present the case of a 2-year-old child with bertiellosis. He had recurrent abdominal pain, and worm fragments were found in stool, which were refractory to albendazole therapy.
October 18, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29035859/gastrointestinal-nematodes-infections-and-anthelmintic-resistance-in-grazing-sheep-in-the-eastern-inner-mongolia-in-china
#4
Tianlong Han, Min Wang, Guanghe Zhang, Dongsheng Han, Xinwei Li, Guowen Liu, Xiaobing Li, Zhe Wang
Gastrointestinal nematodes (GIN) are a crucial restraint to grazing sheep production worldwide. This study was conducted to determine the infections and anthelmintic resistance (AR) of GIN in pasture-based sheep in the Eastern Inner Mongolia, China. GIN eggs were tested from 600 grazing sheep feces of 10 farms using saturated saline flotation method and McMaster's method. The egg hatch test (EHT) and the faecal egg count reduction test (FECRT) were used to evaluate resistance of GIN to anthelmintics. We found that the average infection rate was 79...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29034951/a-nanocrystal-based-formulation-improves-the-pharmacokinetic-performance-and-therapeutic-response-of-albendazole-in-dogs
#5
Alejandro Javier Paredes, Nicolás Litterio, Alicia Dib, Daniel Alberto Allemandi, Carlos Lanusse, Sergio Sánchez Bruni, Santiago Daniel Palma
OBJECTIVES: Here, we aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an albendazole (ABZ) nano-sized formulation in dogs. METHODS: In the pharmacokinetic study, ABZ self-dispersible nanocrystals (SDNCS) and a control formulation were administered orally to healthy dogs (n = 6). The concentrations of the sulphoxide metabolite in plasma were determined by high-performance liquid chromatography. For the anthelmintic efficacy trial, SDNCS and a commercially available formulation of ABZ were given to naturally parasitised dogs...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29034651/primary-orbital-hydatid-cyst-a-case-report
#6
Masoud Fallahi Motlagh, Hamid Janghi Aghdam, Behzad Fallahi Motlagh
Hydatid cyst is a rare parasitic infection that involved all organs. It caused by the larval stage of Echinococcus tapeworms. Hydatid cyst of the head and neck is a very rare condition, even in areas where Echinococcus infestation is endemic. Orbital hydatid cyst is extremely rare and accounts for less than 1% of all hydatid cysts. Herein a 24-year-old man with primary orbital hydatid cyst is introduced. He complained from proptosis and diplopia. MRI images revealed a lesion with low signal intensity on T1-weighted images and high signal intensity on T2-weighted images, which displaced the optic nerve inferiorly and the globe inferolateral...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29032596/limited-effect-of-adaptive-immune-response-to-control-encephalitozoonosis
#7
Bohumil Sak, Michaela Kotková, Lenka Hlásková, Martin Kváč
This study revises our understanding of the effectiveness of cell-mediated adaptive immunity and treatment against microsporidia using molecular detection and quantification of microsporidia in immunocompetent C57Bl/6 and immunodeficient CD4(-/-) and CD8(-/-) mice for the first time. We demonstrate an intense dissemination of microsporidia into most organs within the first weeks post infection in all strains of mice, followed by a chronic infection characterized by microsporidia persistence in CD4(-/-) and C57Bl/6 mice and a lethal outcome for CD8(-/-) mice...
October 15, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29030043/quality-of-anthelminthic-medicines-available-in-jimma-ethiopia
#8
Sileshi Belew, Sultan Suleman, Evelien Wynendaele, Matthias D'Hondt, Anne Kosgei, Luc Duchateau, Bart De Spiegeleer
Soil-transmitted helminthiasis and schistosomiasis are major public health problems in Ethiopia. Mass deworming of at-risk population using a single dose administration of 400mg albendazole (ABZ) or 500mg mebendazole (MBZ) for treatment of common intestinal worms and 40mg of praziquantel (PZQ) per kg body weight for treatment of schistosomiasis is one of the strategies recommended by World Health Organization (WHO) in order to control the morbidity of soil-transmitted helminthiasis and schistosomiasis. Since storage condition, climate, way of transportation and distribution route could all affect the quality of medicines, regular assessment by surveys is very critical to ensure the therapeutic outcome, to minimize risk of toxicity to the patient and resistance of parasites...
October 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29016352/in-vitro-ovicidal-activity-of-poly-lactic-acid-curcumin-nisin-co-entrapped-nanoparticle-against-fasciola-spp-eggs-and-its-reproductive-toxicity
#9
Oyetunde Oyeyemi, Odunayo Adegbeyeni, Ifeoluwa Oyeyemi, Jairam Meena, Amulya Panda
BACKGROUND: Curcumin and nisin have been widely reported for their antibacterial and anticancer potency. However, their therapeutic applications are hampered by several factors, which necessitate their development into nanosize ranges for improved delivery and activities. Their incorporation into a single nanosynthesized form may suggest desirable efficacy on parasites. The aim of the study was to assess the ovicidal activity of the curcumin-nisin polylactic acid (PLA) entrapped nanoparticle on the Fasciola eggs and its reproductive toxicity...
October 10, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29016329/preliminary-evaluation-of-percutaneous-treatment-of-echinococcal-cysts-without-injection-of-scolicidal-agent
#10
Giovanni Firpo, Ambra Vola, Raffaella Lissandrin, Francesca Tamarozzi, Enrico Brunetti
Puncture, Aspiration, Injection of scolicidal agent, Re-aspiration is the most widely used percutaneous treatment of cystic echinococcosis (CE). Among its perceived risks is chemical sclerosing cholangitis, a serious complication due to the caustic effect of the scolicidal solution on the biliary tree, when a patent cystobiliary fistula occurs. To simplify the protocol, we decided to omit injection and reaspiration of the scolicidal agent and to implement a full course of albendazole (ABZ) therapy instead of the routine 1-month ABZ prophylaxis...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991899/albendazole-and-ivermectin-for-the-control-of-soil-transmitted-helminths-in-an-area-with-high-prevalence-of-strongyloides-stercoralis-and-hookworm-in-northwestern-argentina-a-community-based-pragmatic-study
#11
Adriana Echazú, Marisa Juarez, Paola A Vargas, Silvana P Cajal, Ruben O Cimino, Viviana Heredia, Silvia Caropresi, Gladys Paredes, Luis M Arias, Marcelo Abril, Silvia Gold, Patrick Lammie, Alejandro J Krolewiecki
BACKGROUND: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate control, particularly against Strongyloides stercoralis. The impact of preventive chemotherapy (PC) against STH morbidity is still incompletely understood. The aim of this study was to assess the effectiveness of a community-based program with albendazole and ivermectin in a high transmission setting for S...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28990848/enhancement-of-the-therapeutic-effect-of-albendazole-on-cystic-echinococcosis-using-a-herbal-product
#12
Mohammad Moazeni, Hassan Borji, Meysam Saboor Darbandi
PURPOSE: Albendazole is the drug of choice for chemotherapy of cystic echinococcosis (CE) but 40% of patients do not respond to it satisfactorily. With regard to the previously reported scolicidal activity of Zataria multiflora, this study was done to evaluate the efficacy of the co-administration of albendazole and Z. multiflora aromatic water (AW) on hydatid cysts in a murine model. MATERIALS AND METHODS: Laboratory mice were infected with 1,500 viable protoscoleces...
October 9, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28981899/in-vitro-and-in-vivo-efficacies-of-novel-carbazole-aminoalcohols-in-the-treatment-of-cystic-echinococcosis
#13
Weisi Wang, Jun Li, Junmin Yao, Tian Wang, Shizhu Li, Xueting Zheng, Liping Duan, Wenbao Zhang
Objectives: Cystic echinococcosis (CE), caused by the cestode Echinococcus granulosus , is a worldwide chronic zoonosis. Current chemotherapeutic options are limited to albendazole and mebendazole, which only exert parasitostatic effects and have to be administered at high dosages for long periods. In an effort to find alternative treatment options, the in vitro and in vivo efficacies of novel carbazole aminoalcohols were evaluated. Methods: Carbazole aminoalcohols were tested against E...
July 24, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28979347/prevalence-and-molecular-aspects-of-human-hookworms-in-guilan-province-northern-iran
#14
Meysam Sharifdini, Laleh Ghanbarzadeh, Nasrolla Kouhestani-Maklavani, Hamed Mirjalali, Mehrzad Saraei
BACKGROUND: Hookworm infection is one of the important Neglected Tropical Diseases (NTD) in the world. It was previously more prevalent in the northern and southern parts of Iran with a prevalence rate higher than 40% in some endemic regions; nevertheless, the infection rate has decreased to less than 1%. This study aimed to determine prevalence and molecular aspects of hookworm infections in rural inhabitants of Fouman County, Guilan Province, northern Iran. METHODS: This cross-sectional study was performed in 31 villages of Fouman district in Guilan Province, northern Iran during 2015-2016...
July 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28976239/anthelmintic-drugs-their-efficacy-and-cost-effectiveness-in-different-parity-cattle
#15
Muhammad Saqib Ali, Khalid Saeed, Muhmmad Imran Rashid, Muhammad Ijaz, Haroon Akbar, Muhammad Rashid, Kamran Ashraf
Gastrointestinal nematodes are responsible for economic losses in bovines and are characterized by reduced milk production, decreased working efficiency and even death. In our study, the effect of different anthelmintic treatments on nematode control in different parity cattle (Friesian Crossbreds) at calving and their effect on milk yield was evaluated. Economic of anthelmintic and farm benefit in term of increase milk production after deworming was also calculated. We screened cattle of first and second parity for nematodes...
October 4, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28969840/experimental-cystic-echinococcosis-therapy-in-vitro-and-in-vivo-combined-5-fluorouracil-albendazole-treatment
#16
Patricia E Pensel, Natalia Elissondo, Guillermo Gambino, Gabriela Ullio Gamboa, J P Benoit, María C Elissondo
Human cystic echinococcosis is a zoonosis caused by the larval stage of the tapeworm Echinococcus granulosus sensu lato (s. l.). Although benzimidazole compounds such as albendazole (ABZ) and mebendazole have been the cornerstone of chemotherapy for the disease, there is often no complete recovery after treatment. Hence, new strategies are required to improve treatment of human cystic echinococcosis. The goals of the current study were as follows: (i) to evaluate the in vitro efficacy of the 5-fluorouracil (5-FU) and ABZ combination against E...
October 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28969782/application-of-a-coproantigen-elisa-as-an-indicator-of-efficacy-against-multiple-life-stages-of-fasciola-hepatica-infections-in-sheep
#17
S D George, K Vanhoff, K Baker, L Lake, P F Rolfe, W Seewald, D L Emery
At present diagnosis of true resistance and determination of drug efficacy in Fasciola hepatica infection rely solely on terminal experiments. The coproantigen ELISA (cELISA) has been reported previously as a sensitive and specific tool appropriate to detect treatment failure, and potentially drug resistance. Two studies were conducted to determine whether the cELISA was appropriate for on-farm efficacy and resistance testing in Australian Merino sheep. In Study 1 sheep were infected orally with 50 F. hepatica metacercariae on three occasions, twelve, six and two weeks prior to a single flukicide treatment with triclabendazole, closantel or albendazole...
November 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28969715/community-based-trial-of-annual-versus-biannual-single-dose-ivermectin-plus-albendazole-against-wuchereria-bancrofti-infection-in-human-and-mosquito-populations-study-protocol-for-a-cluster-randomised-controlled-trial
#18
Dziedzom K de Souza, Collins S Ahorlu, Susan Adu-Amankwah, Joseph Otchere, Sedzro K Mensah, Irene A Larbi, George E Mensah, Nana-Kwadwo Biritwum, Daniel A Boakye
BACKGROUND: The Global Programme for the Elimination of Lymphatic Filariasis (GPELF) has been in operation since the year 2000, with the aim of eliminating the disease by the year 2020, following five to six rounds of effective annual mass drug administration (MDA). The treatment regimen is ivermectin (IVM) in combination with diethylcarbamazine (DEC) or albendazole (ALB). In Ghana, MDA has been undertaken since 2001. While the disease has been eliminated in many areas, transmission has persisted in some implementation units that had experienced 15 or more rounds of MDA...
October 2, 2017: Trials
https://www.readbyqxmd.com/read/28961920/benzimidazoles-promote-anti-tnf-mediated-induction-of-regulatory-macrophages-and-enhance-therapeutic-efficacy-in-a-murine-model
#19
Manon E Wildenberg, Alon D Levin, Alessandro Ceroni, Zhen Guo, Pim J Koelink, Theodorus B M Hakvoort, Liset Westera, Felicia M Bloemendaal, Johannan F Brandse, Alison Simmons, Geert R D'Haens, Daniel Ebner, Gijs R van den Brink
Background and aims: Regulatory macrophages play a critical role in tissue repair and we have previously shown that anti-TNF antibodies induce these macrophages in vitro and in vivo in IBD patients. The induction of regulatory macrophages can be potentiated using the combination of anti-TNF and thiopurines, consistent with the enhanced efficacy of this combination therapy described in clinical trials. As thiopurines are unfortunately associated with significant side effects, we here aimed to identify alternatives for combination therapy with anti-TNF, using the macrophage induction model as a screening tool...
August 16, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28958014/intracardiac-and-pulmonary-artery-hydatidosis-causing-thromboembolic-pulmonary-hypertension
#20
Gökçen Orhan, Murat Bastopcu, Bülent Aydemir, Mehmet Sait Ersoz
Hydatidosis is a serious parasitic infection in endemic areas. A rare presentation is pulmonary arterial cysts causing thromboembolic pulmonary hypertension. We report the case of a young man who presented with clinical and radiological findings of thromboembolic pulmonary hypertension. The patient was found to have hydatid cysts in both pulmonary arteries and in the right ventricular outflow tract. To remove all cysts without causing rupture, anaphylactic shock or systemic emboli, placing the patient under cardiopulmonary arrest was necessary, and in the case of pulmonary arterial involvement, total circulatory arrest was necessary...
September 7, 2017: European Journal of Cardio-thoracic Surgery
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