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poisoning by acids

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https://www.readbyqxmd.com/read/28530403/propitious-dendritic-cu2o%C3%AF-pt-nanostructured-anodes-for-direct-formic-acid-fuel-cells
#1
Gumaa A El-Nagar, Ahmad M Mohammad, Mohamed S El-Deab, Bahgat E El-Anadouli
This study introduces a novel competent dendritic copper oxide-platinum nanocatalyst (nano-Cu2O-Pt) immobilized onto a glassy carbon (GC) substrate for formic acid (FA) electrooxidation (FAO); the prime reaction in the anodic compartment of direct formic acid fuel cells (DFAFCs). Interestingly, the proposed catalyst exhibited an outstanding improvement for FAO compared to the traditional platinum nanoparticles (nano-Pt) modified GC (nano-Pt/GC) catalyst. This was evaluated from steering the reaction mechanism towards the desired direct route producing carbon dioxide (CO2); consistently with mitigating the other undesired indirect pathway producing carbon monoxide (CO); the potential poison deteriorating the catalytic activity of typical Pt-based catalysts...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28513110/separation-and-purification-of-two-minor-typical-diarrhetic-shellfish-poisoning-toxins-from-harmful-marine-microalgae-via-combined-liquid-chromatography-with-mass-spectrometric-detection
#2
Junhui Chen, Yanlong Wang, Lei Pan, Huihui Shen, Dan Fu, Boqiang Fu, Chengjun Sun, Li Zheng
A novel method was developed for the purification of two typical diarrhetic shellfish poisoning toxins from toxin-producing marine microalgae using macroporous resin, high-speed counter-current chromatography-mass spectrometry, and semi-preparative high-performance liquid chromatography-mass spectrometry (HPLC-MS). Analytical HPLC-MS was used for identification and purity analysis of okadaic acid and dinophysistoxin-1 because they exhibit no visible or ultraviolet absorption. First, four kinds of macroporous resins were investigated, and HP-20 macroporous resin was selected for the pre-enrichment and cleanup of the two target toxins...
May 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28506107/immunoassay-approach-for-diagnosis-of-exposure-to-pyrrolizidine-alkaloids
#3
Na Li, Fan Zhang, Wei Lian, Huali Wang, Jiang Zheng, Ge Lin
Numerous pyrrolizidine alkaloid (PA) poisoning cases have been documented worldwide. Protein covalent binding with reactive metabolites generated from metabolic activation of PAs to form pyrrole-protein adducts is suggested to be a primary mechanism of PA-induced toxicities. Present study aimed to develop antibodies for diagnosis of PA exposure. Polyclonal antibodies were raised in rabbits and proven to specifically recognize pyrrole-protein adducts regardless of amino acid residues modified by the reactive metabolites of PAs...
May 16, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28504347/a-rapid-method-to-screen-poisoning-causative-agents-in-an-acute-care-hospital-in-japan
#4
K Usui, H Mori, T Tachi, T Matsumura, K Mori, A Takeda, Y Noguchi, T Yoshimura, H Teramachi
WHAT IS KNOWN AND OBJECTIVE: A simple, rapid analysis is required to simultaneously analyse medicinal toxicants in emergency medical care. In this regard, the analysis of blood samples by LC-MS/MS equipped with a spin column, involving a rapid, simple pretreatment, has attracted attention. In this study, sample pretreatment using a Monospin C18 column was performed to screen 11 medicinal toxicants in blood samples by LC-MS/MS. METHODS: Serum samples supplemented with 11 medical toxicants-acetaminophen, salicylic acid, nitrazepam, diphenhydramine, bromvalerylurea, phenobarbital, amitriptyline, risperidone, fenitrothion, malathion and methomyl-were pretreated with the Monospin C18 column according to Pretreatment I and Pretreatment II, followed by LC-MS/MS analysis...
May 15, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28499205/comparative-metabolomics-analysis-for-the-compatibility-and-incompatibility-of-kansui-and-licorice-with-different-ratios-by-uhplc-qtof-ms-and-multivariate-data-analysis
#5
Juan Shen, Zong-Jin Pu, Jun Kai, An Kang, Yu-Ping Tang, Li-Li Shang, Gui-Sheng Zhou, Zhen-Hua Zhu, Er-Xin Shang, Shao-Ping Li, Yu-Jie Cao, Wei-Wei Tao, Shu-Lan Su, Li Zhang, Huiping Zhou, Da-Wei Qian, Jin-Ao Duan
Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical "eighteen incompatible" medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), and the efficacy could be weakened by the co-use of licorice, even causing serious toxicity at the given ratio. Nevertheless, the actual mechanisms of their dosage-toxicity-efficacy relationship need to be well clarified...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28494418/zingiber-officinale-and-6-gingerol-alleviate-liver-and-kidney-dysfunctions-and-oxidative-stress-induced-by-mercuric-chloride-in-male-rats-a-protective-approach
#6
Deepmala Joshi, Sunil Kumar Srivastav, Sateesh Belemkar, Vaibhav A Dixit
Mercury toxicity is an emerging problem in the world as its concentration is rising continuously due to increased industrial, medicinal and domestic uses. Exposure to mercury represents a serious challenge to humans and other living biomes. The aim of the present study was to assess the protective effect of natural products as Zingiber officinale extract and its active compound (6-gingerol) against mercuric chloride-induced hepatorenal toxicity and oxidative stress in male rats. Male Sprague-Dawley rats (150±10g, n=6 per group) were administered HgCl2 (12μmol/kg, ip; once only) the treatment of Zingiber officinale Rosc...
May 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28494246/catalytic-hydrodechlorination-of-triclosan-using-a-new-class-of-anion-exchange-resin-supported-palladium-catalysts
#7
Bing Han, Wen Liu, Jingwen Li, Jin Wang, Dongye Zhao, Rui Xu, Zhang Lin
We prepared a new class of anion-exchange-resin supported Pd catalysts for efficient hydrodechlorination of triclosan in water. The catalysts were prepared through an initial ion-exchange uptake of PdCl4(2-) and subsequent reduction of Pd(II) to Pd(0) nanoparticles at ambient temperature. Two standard strong-base anion exchange resins (IRA-900 and IRA-958) with different matrices (polystyrene and polyacrylic) were chosen as the supports. SEM and TEM images showed that Pd(0) nanoparticles were evenly attached on the resin surface with a mean size of 3-5 nm...
April 26, 2017: Water Research
https://www.readbyqxmd.com/read/28485057/affinity-capillary-electrophoresis-and-density-functional-theory-study-of-noncovalent-interactions-of-cyclic-peptide-gly-6-antamanide-with-small-cations
#8
Sachin Pangavhane, Stanislav Böhm, Emanuel Makrlík, Paolo Ruzza, Václav Kašička
ACE and density functional theory (DFT) were employed to study the noncovalent interactions of cyclic decapeptide glycine-6-antamanide ([Gly(6) ]AA), synthetic derivative of native antamanide peptide from the deadly poisonous fungus Amanita phaloides, with small cations (Li(+) , Rb(+) , Cs(+) , NH4(+) , and Ca(2+) ) in methanol. The strength of these interactions was quantified by the apparent stability constants of the appropriate complexes determined by ACE. The stability constants were calculated using the nonlinear regression analysis of the dependence of the effective electrophoretic mobility of [Gly(6) ]AA on the concentration of the above ions in the BGE (methanolic solution of 20 mM chloroacetic acid, 10 mM Tris, pHMeOH 7...
May 9, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28481454/severe-acute-valproic-acid-intoxication-successfully-treated-with-liver-support-therapy
#9
Yongchun Ge, Bin Xu, Chuan Li, Qunpeng He, Tingting Zhu, Rong Fan, Dehua Gong
Valproic acid (VPA) is widely used for treatment of epilepsy. However, its overdose can cause intoxication and could be life-threatening. Due to lack of specific antidote and poorness of endogenous clearance, extracorporeal treatment for severe intoxication cases is indicated. Here, we report a case of severe intoxication of VPA which was successfully treated with liver support therapy. A previously healthy woman was admitted due to coma and hypotension after intentional ingestion of 20 g of sodium valproate...
May 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28476772/biosynthesis-of-the-pharmaceutically-important-fungal-ergot-alkaloid-dihydrolysergic-acid-requires-a-specialized-allele-of-cloa
#10
Stephanie L Arnold, Daniel G Panaccione
Ergot alkaloids are fungal specialized metabolites that are important as the bases of several pharmaceuticals. Many ergot alkaloids are derivatives of lysergic acid (LA) and have vasoconstrictive activity, whereas several dihydrolysergic acid (DHLA) derivatives are vasorelaxant. The pathway to LA is established, with the P450 monooxygenase CloA playing a key role in oxidizing its substrate agroclavine to LA. We analyzed the activities of products of cloA alleles from different fungi relative to DHLA biosynthesis by expressing them in a mutant of the fungus Neosartorya fumigata that accumulates festuclavine, the precursor to DHLA...
May 5, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28476005/toxicological-implications-of-selenium-nanoparticles-with-different-coatings-along-with-se-4-on-lemna-minor
#11
Roshanak Tarrahi, Alireza Khataee, Ali Movafeghi, Farkhondeh Rezanejad, Gholamreza Gohari
Nanoparticles have potential high risks for living organisms in the environment due to their specific qualities and their easy access. In the present study, selenium nanoparticles (Se NPs) with two different coatings (l-cysteine and tannic acid) were synthesized. The characteristics of particles were analyzed using XRD, FT-IR and SEM. The impact of the nanoparticles besides Se(4+), on the aquatic higher plant Lemna minor was evaluated and compared. Entrance of l-cysteine and tannic acid capped Se NPs in the roots of Lemna minor was proved by TEM and fluorescence microscopy...
April 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28467517/anti-cancer-stemness-and-anti-invasive-activity-of-bitter-taste-receptors-tas2r8-and-tas2r10-in-human-neuroblastoma-cells
#12
Yoona Seo, Yoo-Sun Kim, Kyung Eun Lee, Tai Hyun Park, Yuri Kim
Neuroblastoma (NB) originates from immature neuronal cells and currently has a poor clinical outcome. NB cells possess cancer stem cells (CSCs) characteristics that facilitate the initiation of a tumor, as well as its metastasis. Human bitter taste receptors, referred to as TAS2Rs, are one of five types of basic taste receptors and they belong to a family of G-protein coupled receptors. The recent finding that taste receptors are expressed in non-gustatory tissues suggest that they mediate additional functions distinct from taste perception...
2017: PloS One
https://www.readbyqxmd.com/read/28463017/unintentional-ingestion-of-cordyceps-fungus-infected-cicada-nymphs-causing-ibotenic-acid-poisoning-in-southern-vietnam
#13
Uyen Vy Doan, Bomar Mendez Rojas, Ralph Kirby
BACKGROUND: Cordyceps fungus found in infected cicada nymphs ("cicada flowers") is utilized in traditional Chinese medicine. Cordyceps fungus toxicity in humans has not been previously reported. We report 60 cases of apparent Cordyceps poisoning in Southern Vietnam. METHODS: We retrospectively collected demographic and clinical data from the medical records (21 cases) and by telephone interview (39 cases) of patients admitted to seven hospitals in Southern Vietnam following ingestion of cicada flowers between 2008 and 2015...
May 2, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28457442/synthesis-of-hybrid-paper-sheets-with-enhanced-air-barrier-and-antimicrobial-properties-for-food-packaging
#14
Magda A El-Samahy, Salah A A Mohamed, Mona H Abdel Rehim, Maysa E Mohram
Paper sheets made from bagasse pulp have been modified using nanocellulose (NC) obtained from the same raw material. Modification of paper sheets have been carried out either through loading of paper with different concentrations of NC and antibacterial agent, Chitosan (Ch) during making sheets, or by surface coating of the paper. Crystals of NC extracted using concentrated sulfuric acid from bagasse pulp were found to have crystallinity index (CrI) 90%. Morphology of obtained NC has been confirmed by TEM and images revealed formation of NC crystals with large size distribution ranges from 4 to 60nm...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28454589/prevalence-and-antimicrobial-resistance-profile-of-staphylococcus-in-dairy-farms-abattoir-and-humans-in-addis-ababa-ethiopia
#15
Takele Beyene, Halefom Hayishe, Fikru Gizaw, Ashenafi Feyisa Beyi, Fufa Abunna, Bedaso Mammo, Dinka Ayana, Hika Waktole, Reta Duguma Abdi
BACKGROUND: Staphylococcus species cause mastitis and wound infection in livestock and food poisoning in humans through ingestion of contaminated foods, including meat and dairy products. They are evolving pathogens in that they readily acquire drug resistance, and multiple drug-resistant (MDR) isolates are increasing in human and veterinary healthcare. Therefore, this study was conducted to evaluate the prevalence of Staphylococci and their drug resistance in dairy farms and abattoir settings of Addis Ababa...
April 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28444877/identification-and-measurement-of-staphylococcal-enterotoxin-m-sem-from-staphylococcus-aureus-isolate-associated-with-staphylococcal-food-poisoning
#16
Yanying Zhao, Anni Zhu, Junni Tang, Cheng Tang, Juan Chen
Staphylococcus aureus (S. aureus) produces a wide variety of staphylococcal enterotoxins (SEs, SEA to SEX), which are responsible for staphylococcal food poisoning. This study is aimed to establish a system to detect SEM protein in food matrixes. In the present study, sem gene was characterized in a S. aureus isolate H4 associated with food poisoning. The amino acid sequence of the deduced SEM protein was same as that of previously identified SEM from S. aureus 04-02981. Subsequently, mature SEM protein was expressed in E...
April 26, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28442131/multipoint-recognition-of-domoic-acid-from-seawater-by-dummy-template-molecularly-imprinted-solid-phase-extraction-coupled-with-high-performance-liquid-chromatography
#17
Xiuping He, Jianlei Chen, Jiangtao Wang, Liju Tan
Due to the high cost of domoic acid (DA), different carboxylic acid compounds including indole-3-acetic acid (IAA), pyrrole-2-formic acid (PFA), pyridine-2,3-dicarboxylic anhydride (PDA), trimesitinic acid (TA) and citric acid (CA) were investigated as dummy templates for the molecularly imprinted solid-phase extraction (MISPE) for selective isolation and pre-concentration of an amnesic shellfish poison (ASP), DA. The highest binding amount of the polymers towards DA was obtained when CA was used as dummy template owing to its high hydrophilicity...
April 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28425396/development-and-single-laboratory-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-quantitation-of-tetrodotoxin-in-mussels-and-oysters
#18
Andrew D Turner, Michael J Boundy, Monika Dhanji Rapkova
In recent years, evidence has grown for the presence of tetrodotoxin (TTX) in bivalve mollusks, leading to the potential for consumers of contaminated products to be affected by Tetrodotoxin Shellfish Poisoning (TSP). A single-laboratory validation was conducted for the hydrophilic interaction LC (HILIC) tandem MS (MS/MS) analysis of TTX in common mussels and Pacific oysters-the bivalve species that have been found to contain TTXs in the United Kingdom in recent years. The method consists of a single-step dispersive extraction in 1% acetic acid, followed by a carbon SPE cleanup step before dilution and instrumental analysis...
April 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28425351/metabolic-changes-in-methomyl-poisoned-rats-treated-by-vitamin-e
#19
J Weng, B Cai, J Chen, B Chen, H Wu, C Wen, F Sun, L Hu, C Chen, X Wang, Z Wang
In this study, we developed a serum and urine metabolomic method based on gas chromatography-mass spectrometry (GC-MS) combination with biomedical results to evaluate the effect of vitamin E treatment on methomyl poisoning rats. The rats were divided into three groups: the control group, methomyl poisoning group, and vitamin E treatment group. Partial least squares discriminate analysis (PLS-DA) showed that methomyl poisoning induced metabolic perturbations. Compared to the control group, based on the urinary metabolomics data, the level of ribitol, l-proline, xylitol, hydrocinnamic acid, 11-cis-octadecenoic acid, octadecanoic acid, and hexadecanoic acid of methomyl poisoning group increased, while the level of 2,3,4-trihydroxybutyric acid, ethanimidic acid, pantothenic acid, and retinoic acid decreased...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28414161/metabolism-of-okadaic-acid-by-nadph-dependent-enzymes-present-in-human-or-rat-liver-s9-fractions-results-in-different-toxic-effects
#20
Franziska Kolrep, Kathleen Rein, Alfonso Lampen, Stefanie Hessel-Pras
The lipophilic marine biotoxin okadaic acid (OA) represents a natural contaminant produced by algae accumulating in seafood. Acute intoxications result in diarrhetic shellfish poisoning causing symptoms like nausea, vomiting and abdominal cramps. OA was preincubated with liver enzymes present in S9 fractions from humans, rats and rats pretreated with enzyme inducers in the presence or absence of the cofactor NADPH to investigate hepatic metabolism. Cytotoxicity was examined in HepG2 cells and metabolites of OA were determined by LC-MS/MS...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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