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https://www.readbyqxmd.com/read/27919185/modeling-the-effect-of-succimer-dmsa-dimercaptosuccinic-acid-chelation-therapy-in-patients-poisoned-by-lead
#1
Jan C H van Eijkeren, J Daniël N Olie, Sally M Bradberry, J Allister Vale, Irma de Vries, Harvey J Clewell, Jan Meulenbelt, Claudine C Hunault
CONTEXT: Kinetic models could assist clinicians potentially in managing cases of lead poisoning. Several models exist that can simulate lead kinetics but none of them can predict the effect of chelation in lead poisoning. Our aim was to devise a model to predict the effect of succimer (dimercaptosuccinic acid; DMSA) chelation therapy on blood lead concentrations. MATERIALS AND METHODS: We integrated a two-compartment kinetic succimer model into an existing PBPK lead model and produced a Chelation Lead Therapy (CLT) model...
December 5, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27915048/protective-effects-of-green-tea-and-its-main-constituents-against-natural-and-chemical-toxins-a-comprehensive-review
#2
REVIEW
Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
Toxins are natural or chemical poisonous substances with severe side effects on health. Humans are generally exposed by widespread toxic contaminations via air, soil, water, food, fruits and vegetables. Determining a critical antidote agent with extensive effects on different toxins is an ultimate goal for all toxicologists. Traditional medicine is currently perceived as a safe and natural approach against toxins. In this regard, we focused on the protective effects of green tea (Camellia sinensis) and its main components such as catechin, epicatechin, epicatechin gallate, gallocatechin, epigallocatechin and epigallocatechin gallate as a principal source of antioxidants against both natural and chemical toxins...
November 30, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27910775/hepatoprotective-effects-and-mechanisms-of-action-of-triterpenoids-from-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-on-%C3%AE-amanitin-induced-liver-injury-in-mice
#3
Huihui Wu, Shanshan Tang, Zhaoqin Huang, Qian Zhou, Ping Zhang, Zuohong Chen
Most fatal mushroom poisonings are caused by species of the genus Amanita; the amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27906402/one-step-synthesis-of-ultrathin-ptxpb-nerve-like-nanowires-as-robust-catalysts-for-enhanced-methanol-electrooxidation
#4
Liang Huang, Yujie Han, Xueping Zhang, Youxing Fang, Shaojun Dong
Ultrathin PtxPb nerve-like nanowires (NNWs) with a diameter of only around 3.6 nm were synthesized by a one-step wet-chemical strategy, and they served as robust catalysts for greatly enhancing methanol electrooxidation both under acidic and alkaline conditions. Due to the high CO-poisoning tolerance, superior electrocatalytic activity and stability endowed by the Pt-Pb alloyed composition and the unique structure, the Pt3.5Pb NNWs showed the highest specific activity of 2.78 mA cm(-2) in acidic media and 6...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27893431/dysregulated-human-tyrosyl-dna-phosphodiesterase-i-acts-as-cellular-toxin
#5
Selma M Cuya, Evan Q Comeaux, Keith Wanzeck, Karina J Yoon, Robert C A M van Waardenburg
Tyrosyl-DNA phosphodiesterase I (TDP1) hydrolyzes the drug-stabilized 3'phospho-tyrosyl bond formed between DNA topoisomerase I (TOPO1) and DNA. TDP1-mediated hydrolysis uses a nucleophilic histidine (Hisnuc) and a general acid/base histidine (Hisgab). A Tdp1Hisgab to Arg mutant identified in patients with the autosomal recessive neurodegenerative disease SCAN1 causes stabilization of the TDP1-DNA intermediate. Based on our previously reported Hisgab-substitutions inducing yeast toxicity (Gajewski et al. J...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27890093/3-nitropropionic-acid-production-by-the-endophytic-diaporthe-citri-molecular-taxonomy-chemical-characterization-and-quantification-under-ph-variation
#6
Julio Cesar Polonio, Marcos Alessandro Dos Santos Ribeiro, Sandro Augusto Rhoden, Maria Helena Sarragiotto, João Lúcio Azevedo, João Alencar Pamphile
3-nitropropionic acid (3-NPA) is a nitrogenated compound produced by plants and fungi and has been associated with poisoning episodes in humans, animals, and to induction of Huntington disease symptoms in rats. The production of 3-NPA by endophytes has been reported, but the function and biosynthesis are not well-defined. The specie of endophytic strain G-01 was confirmed as Diaporthe citri using a multilocus sequence analysis, and was verified different concentrations of 3-NPA produced at different initial pHs by these strain...
December 2016: Fungal Biology
https://www.readbyqxmd.com/read/27866556/-clinical-analysis-of-5-patients-caused-by-acute-inhalation-of-phosphoric-acid-gas-poisoning
#7
J G Dong, Z W Qiu, H C Wang
No abstract text is available yet for this article.
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27860418/one-pot-selective-catalytic-synthesis-of-pyrrolidone-derivatives-from-ethyl-levulinate-and-nitro-compounds
#8
Avelino Corma, Juan Diego Vidal, Maria Jose Climent, Patricia Concepcion, Sara Iborra
N-substituted-5-methyl-2-pyrrolidones have been prepared in one pot process starting from ethyl levulinate and nitro compounds and in the presence of nanosized platinum based catalyst. Pt supported on TiO2 nanotubes (Pt/TiO2-NT) catalyzes the synthesis of N-substituted-5-methyl-2-pyrrolidones through a cascade process which involves the reduction of nitro compounds, formation of the intermediary imine, hydrogenation and subsequent cyclization. A bifunctional metal-acid system works for the process. Pt on TiO2 gives lower catalytic activity than Pt/TiO2-NT due to the strong adsorption of nitro compounds during the first reaction step that poisons the acidic sites and strongly decreases the rate of amination and cyclization steps...
November 8, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27812240/investigation-of-the-h2s-poisoning-process-for-sensing-composite-material-based-on-carbon-nanotubes-and-metal-oxides
#9
Yichen Duan, Laurent Pirolli, Andrew V Teplyakov
The poisoning of H2S sensing material based on the mixture of acid-treated carbon nanotubes, CuO and SnO2 was investigated by exposing the material to high doses of H2S (1% in volume) and following the changes spectroscopically. The presence of metal sulfides (CuS and SnS2), sulfates and thiols was confirmed on the surface of this material as the result of H2S poisoning. Further study revealed that leaving this material in air for extended period of time led to reoxidation of metal sulfides back to metal oxides...
November 1, 2016: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/27799742/n-acetylcysteine-and-meso-2-3-dimercaptosuccinic-acid-alleviate-oxidative-stress-and-hepatic-dysfunction-induced-by-sodium-arsenite-in-male-rats
#10
Ahmed M Abu El-Saad, Mohammed A Al-Kahtani, Ashraf M Abdel-Moneim
Environmental exposure to arsenic represents a serious challenge to humans and other animals. The aim of the present study was to test the protective effect of antioxidant N-acetylcysteine (NAC) either individually or in combination with a chelating agent, meso-2,3-dimercaptosuccinic acid (DMSA), against sodium arsenite oral toxicity in male rats. Five groups were used: control; arsenic group (orally administrated in a concentration of 2 mg/kg body weight [b.w.]); the other three groups were orally administrated sodium arsenite in a concentration of 2 mg/kg b...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27784805/the-acute-inhibition-of-enteric-glial-metabolism-with-fluoroacetate-alters-calcium-signaling-hemichannel-function-and-the-expression-of-key-proteins
#11
Jonathon L McClain, Brian David Gulbransen
Glia play key roles in the regulation of neurotransmission in the nervous system. Fluoroacetate (FA) is a metabolic poison widely used to study glial functions by disrupting the tricarboxylic acid cycle enzyme aconitase. Despite the widespread use of FA, the effects of FA on essential glial functions such as calcium (Ca(2+)) signaling and hemichannel function remain unknown. Therefore, our goal was to specifically assess the impact of FA on essential glial cell functions that are involved with neurotransmission in the enteric nervous system...
October 26, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27759038/the-stability-and-catalytic-activity-of-w13-pt42-core-shell-structure
#12
Jin-Rong Huo, Xiao-Xu Wang, Lu Li, Hai-Xia Cheng, Yan-Jing Su, Ping Qian
This paper reports a study of the electronic properties, structural stability and catalytic activity of the W13@Pt42 core-shell structure using the First-principles calculations. The degree of corrosion of W13@Pt42 core-shell structure is simulated in acid solutions and through molecular absorption. The absorption energy of OH for this structure is lower than that for Pt55, which inhibits the poison effect of O containing intermediate. Furthermore we present the optimal path of oxygen reduction reaction catalyzed by W13@Pt42...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27752845/histamine-food-poisoning
#13
Maria Schirone, Pierina Visciano, Rosanna Tofalo, Giovanna Suzzi
The consumption of food containing high amounts of histamine and other biogenic amines can cause food poisoning with different symptoms linked to the individual sensitivity and the detoxification activity. Histamine is the only biogenic amine with regulatory limits set by the European Commission in fish and fishery products, because it can lead to a fatal outcome. However, also fermented foods can be involved in outbreaks and sporadic cases of intoxication. The factors affecting the presence of histamine in food are variable and product specific including the availability of the precursor amino acid, the presence of microorganisms producing decarboxylases, and the conditions allowing their growth and enzyme production...
October 18, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27722929/pesticides-an-update-of-human-exposure-and-toxicity
#14
Sara Mostafalou, Mohammad Abdollahi
Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern. Regardless of acute poisonings which are common for some classes of pesticides like organophosphoruses, the association of chronic and sub-lethal exposure to pesticides with a prevalence of some persistent diseases is going to be a phenomenon to which global attention has been attracted. In this review, incidence of various malignant, neurodegenerative, respiratory, reproductive, developmental, and metabolic diseases in relation to different routes of human exposure to pesticides such as occupational, environmental, residential, parental, maternal, and paternal has been systematically criticized in different categories of pesticide toxicities like carcinogenicity, neurotoxicity, pulmonotoxicity, reproductive toxicity, developmental toxicity, and metabolic toxicity...
October 8, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27721858/incidence-and-clinical-course-of-left-ventricular-systolic-dysfunction-in-patients-with-carbon-monoxide-poisoning
#15
Jae-Hwan Lee, Hyun-Sook Kim, Jae-Hyeong Park, Min Su Kim, Byung Joo Sun, Seung Ryu, Song Soo Kim, Seon Ah Jin, Jun Hyung Kim, Si Wan Choi, Jin-Ok Jeong, In-Sun Kwon, In-Whan Seong
BACKGROUND AND OBJECTIVES: Carbon monoxide (CO) poisoning can cause tissue hypoxia and left ventricular systolic dysfunction (LVSD) requiring intensive medical management. Our objectives were to find incidence and clinical course of LVSD CO intoxicated patients and make a clinical scoring to predict LVSD. SUBJECTS AND METHODS: We included all consecutive patients with CO exposure in the emergency room. LVSD was defined by LVEF <50% assessed by echocardiography...
September 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27715504/eco-friendly-peg-based-controlled-release-nano-formulations-of-mancozeb-synthesis-and-bioefficacy-evaluation-against-phytopathogenic-fungi-alternaria-solani-and-sclerotium-rolfsii
#16
Sujan Majumder, Najam A Shakil, Jitendra Kumar, Tirthankar Banerjee, Parimal Sinha, Braj B Singh, Parul Garg
Controlled release (CR) nano-formulations of Mancozeb (manganese-zinc double salt of N,N-bisdithiocarbamic acid), a protective fungicide, have been prepared using laboratory-synthesized poly(ethylene glycols) (PEGs)-based functionalized amphiphilic copolymers without using any surfactants or external additives. The release kinetics of the developed Mancozeb CR formulations were studied and compared with that of commercially available 42% suspension concentrate and 75% wettable powder. Maximum amount of Mancozeb was released on 42nd day for PEG-600 and octyl chain, PEG-1000 and octyl chain, and PEG-600 and hexadecyl chain, on 35th day for PEG-1000 and hexadecyl chain, on 28th day for PEG-1500 and octyl chain, PEG-2000 and octyl chain, PEG-1500 and hexadecyl chain, and PEG-2000 and hexadecyl chain in comparison to both commercial formulations (15th day)...
December 2016: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/27711508/how-do-random-superficial-defects-influence-the-electro-oxidation-of-glycerol-on-pt-111-surfaces
#17
Pablo S Fernández, Polina Tereshchuk, Camilo A Angelucci, Janaina F Gomes, Amanda C Garcia, Cauê A Martins, Giuseppe A Camara, María E Martins, Juarez L F Da Silva, Germano Tremiliosi-Filho
The glycerol electrooxidation reaction (GEOR) has attracted huge interest in the last decade due to the very low price and availability of this polyol. In this work, we studied the GEOR on Pt(111) electrodes by introducing different densities of random defects. Our results showed that the generation of defects on Pt(111) slightly modified the GEOR onset potential, however it generates changes in the voltammetric oxidation charges and also in the relative production of CO2 to carbonyl containing compounds, C[double bond, length as m-dash]O...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27710431/comparative-analysis-of-protective-effects-of-curcumin-curcumin-%C3%AE-cyclodextrin-nanoparticle-and-nanoliposomal-curcumin-on-unsymmetrical-dimethyl-hydrazine-poisoning-in-mice
#18
Wei Li, Mengzhou Zhou, Ning Xu, Yong Hu, Chao Wang, Deyuan Li, Liegang Liu, Dongsheng Li
The aim of this study was to compare the protective effects of curcumin, curcumin-β-cyclodextrin nanoparticle curcumin (BCD-CUR) and nanoliposomal curcumin (NLC) on unsymmetrical dimethylhydrazine (UDMH) induced poison in mice. Curcumin, BCD-CUR, and NLC were prepared and their properties of zeta potential, particle size, encapsulation efficiency, and loading capacity were characterized. Eighty-eight male ICR mice on normal chow diet were randomly divided into 11 groups, and intraperitoneally injected with UDMH alone, or together with different doses of curcumin, BCD-CUR or NLC daily for up to 10 d...
September 2, 2016: Bioengineered
https://www.readbyqxmd.com/read/27710180/modelling-dimercaptosuccinic-acid-dmsa-plasma-kinetics-in-humans
#19
Jan C H van Eijkeren, J Daniël N Olie, Sally M Bradberry, J Allister Vale, Irma de Vries, Jan Meulenbelt, Claudine C Hunault
CONTEXT: No kinetic models presently exist which simulate the effect of chelation therapy on lead blood concentrations in lead poisoning. OBJECTIVE: Our aim was to develop a kinetic model that describes the kinetics of dimercaptosuccinic acid (DMSA; succimer), a commonly used chelating agent, that could be used in developing a lead chelating model. MATERIAL AND METHODS: This was a kinetic modelling study. We used a two-compartment model, with a non-systemic gastrointestinal compartment (gut lumen) and the whole body as one systemic compartment...
November 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27689392/self-protection-mechanism-of-hexagonal-wo3-based-denox-catalysts-against-alkali-poisoning
#20
Li Zheng, Meijuan Zhou, Zhiwei Huang, Yaxin Chen, Jiayi Gao, Zhen Ma, Jianmin Chen, Xingfu Tang
A good catalyst for efficiently controlling NOx emissions often demands strong resistance against alkali poisoning. Although the traditional ion-exchange model, based on acid-base reactions of alkalis with Brønsted acid sites, has been established over the past two decades, it is difficult to be used as a guideline to develop such an alkali-resistant catalyst. Here we establish a self-protection mechanism of deNOx catalysts against alkali poisoning by systematically studying the intrinsic nature of alkali resistance of V2O5/HWO (HWO = hexagonal WO3) that shows excellent resistance to alkali poisoning in selective catalytic reduction of NOx with NH3 (SCR)...
October 12, 2016: Environmental Science & Technology
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