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poisoning by acids

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https://www.readbyqxmd.com/read/29336175/a-new-monoterpene-from-the-poisonous-mushroom-trogia-venenata-which-has-caused-sudden-unexpected-death-in-yunnan-province-china
#1
Ying-Chao Xu, Xiao-Xia Xie, Zhong-Yu Zhou, Tao Feng, Ji-Kai Liu
A new monoterpene, 6,7,8-trihydroxy-2,6-dimethyloctanoic acid (1), and a known sesquiterpene, β-caryophyllene 4R,5R-oxide (2), as well as four known ergosta-steroids, 5α,8α-epidioxyergosta-6,22-dien-3β-y1 linoleate (3), 3-O-β-D-glucopyranosyl-22E,24R-5α,8α-epidioxyergosta-6,22-dien (4), 5α,8α-epidioxy-(22E,24R)-ergosta-6,22-dien-3β-ol (5) and (22E,24R)-ergosta-7,22-dien-3β-ol (6), were isolated from the fruiting bodies of the mushroom Trogia venenata. The structures of these compounds were identified by the analysis of spectral data...
January 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29331713/repeated-attempted-homicide-by-administration-of-drugs-documented-by-hair-analysis
#2
Valérie Baillif-Couniou, Christophe Bartoli, Caroline Sastre, Marjorie Chèze, Marc Deveaux, Georges Léonetti, Anne-Laure Pélissier-Alicot
Attempted murder by repeated poisoning is quite rare. The authors describe the case of a 62-year-old man who was admitted to an intensive care unit (ICU) for neurological disturbances complicated by inhalation pneumopathy. He presented a loss of consciousness while his wife was visiting him at the ICU (H0). Forty-eight hours later (H48), police officers apprehended the patient's wife pouring a liquid into his fruit salad at the hospital. Toxicological analyses of a blood sample and the infusion equipment (H0), as well as the fruit salad and its container (H48), confirmed the attempted poisoning with cyamemazine (H0) and hydrochloric acid (H48)...
January 5, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29330906/generating-retinoic-acid-gradients-by-local-degradation-during-craniofacial-development-one-cell-s-cue-is-another-cell-s-poison
#3
REVIEW
Aditi Dubey, Rebecca E Rose, Drew R Jones, Jean-Pierre Saint-Jeannet
Retinoic acid (RA) is a vital morphogen for early patterning and organogenesis in the developing embryo. RA is a diffusible, lipophilic molecule that signals via nuclear RA receptor heterodimeric units that regulate gene expression by interacting with RA response elements in promoters of a significant number of genes. For precise RA signaling, a robust gradient of the morphogen is required. The developing embryo contains regions that produce RA, and specific intracellular concentrations of RA are created through local degradation mediated by Cyp26 enzymes...
January 13, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29327513/methanol-water-aqueous-phase-reforming-by-the-assistant-of-dehydrogenases-at-near-room-temperature
#4
Yangbin Shen, Yulu Zhan, Shuping Li, Fandi Ning, Ying Du, Yunjie Huang, Ting He, Xiaochun Zhou
As an excellent hydrogen storage medium, methanol has many advantages, such as high hydrogen content (12.6 wt%), low-cost and availability from biomass or photocatalysis. However, conventional methanol-water reforming usually proceeds at high temperature. In this research, we successfully designed a new effective strategy to generate hydrogen from methanol at near-room temperature. The strategy involves two main procedures, which are CH3OH→HCOOH→H2 and NADH→HCOOH→H2. The first procedure (CH3OH→HCOOH→H2) is performed by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH) and the Ir-catalyst...
January 11, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29321805/simultaneous-measurement-of-formic-acid-methanol-and-ethanol-in-vitreous-and-blood-samples-of-postmortem-by-headspace-gc-fid
#5
Hamideh Ghorbani, Alireza Nezami, Behjat Sheikholeslami, Arya Hedjazi, Mahnaz Ahmadimanesh
Background: Formic acid (formate) is the main reason for toxicity and death through methanol poisoning. The simultaneous determination of methanol, ethanol, and formate in the body can help to discover the cause of death and is useful in the diagnosis of acute methanol poisoning. The measurement of formate is not yet available in Iran. With regard to the increasing rate of methanol poisoning and its related mortality in Iran, as well as the main role of formate in methanol poisoning, this study was designed to set up an analytical method for the concurrent determination of ethanol, methanol, and formate...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29321590/six-domoic-acid-related-compounds-from-the-red-alga-chondria-armata-and-domoic-acid-biosynthesis-by-the-diatom-pseudo-nitzschia-multiseries
#6
Yukari Maeno, Yuichi Kotaki, Ryuta Terada, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodomoic acid A (2) and B (3), N-geranyl-L-glutamic acid (4), 7'-hydroxymethyl-isodomoic acid A (5) and B (6), and N-geranyl-3(R)-hydroxy-L-glutamic acid (7), were isolated from the red alga, Chondria armata, and their structures were determined...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313251/unintentional-and-sequential-lead-exposure-from-a-ceramic-mug-and-maca-lepidium-meyenii
#7
Kelly Johnson-Arbor, Kathy Vo, Flavia Wong, Ryszard Gajek
Although the incidence of lead poisoning has decreased in the USA over the last 30 years, human exposures to lead-containing products are still reported. We present a case of unintentional lead exposure from a store-bought ceramic mug and a nutritional supplement. A 32-year-old female was found to have a whole blood lead concentration of 44 μg/dL. Evaluation of her home, occupation, and hobbies initially did not identify a source of lead exposure. Further investigation revealed that the likely etiology of the exposure was lead leaching from a ceramic mug used by the patient to drink hot lemon water while she was pregnant...
January 8, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29313078/preparation-and-application-of-a-molecularly-imprinted-monolith-for-specific-recognition-of-domoic-acid
#8
Fan Yang, Ruirui Wang, Guangshui Na, Qilun Yan, Zhongsheng Lin, Zhifeng Zhang
In this work, a molecularly imprinted monolithic column was synthesized by a facile procedure and was applied for specific recognition of domoic acid, an amnesic shellfish poison. The poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) molecularly imprinted monolith was synthesized in a stainless steel column by in situ polymerization. Pentane-1,3,5-tricarboxylic acid was used as a dummy imprinting template instead of the highly toxic and expensive target molecule. It is the first time that a molecularly imprinted monolith is introduced for separation and detection of domoic acid...
January 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29310404/extracorporeal-membrane-oxygenation-combined-with-continuous-renal-replacement-therapy-in-cutaneous-burn-and-inhalation-injury-caused-by-hydrofluoric-acid-and-nitric-acid
#9
Qinhua Pu, Jinxian Qian, Weiyi Tao, Aixiang Yang, Jian Wu, Yaodong Wang
RATIONALE: Hydrofluoric acid (HF) is a highly corrosive agent and can cause corrosive burns. HF can penetrate deeply into tissues through intact skin and the lipid barrier, leading to painful liquefactive necrosis, and inducing hypocalcemia and hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability in cases of HF poisoning. PATIENT CONCERNS: A 25-year-old man fell into an electroplating pool containing 10% HF and 50% nitric acid...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29301344/computational-modeling-of-the-staphylococcal-enterotoxins-and-its-interaction-with-natural-antitoxin-compounds
#10
Mahantesh Kurjogi, Praveen Satapute, Sudisha Jogaiah, Mostafa Abdelrahman, Jayasimha Rayalu Daddam, Venkatesh Ramu, Lam-Son Phan Tran
Staphylococcus aureus is an opportunistic bacterium that produces various types of toxins, resulting in serious food poisoning. Staphylococcal enterotoxins (SEs) are heat-stable and resistant to hydrolysis by digestive enzymes, representing a potential hazard for consumers worldwide. In the present study, we used amino-acid sequences encoding SEA and SEB-like to identify their respective template structure and build the three-dimensional (3-D) models using homology modeling method. Two natural compounds, Betulin and 28-Norolean-12-en-3-one, were selected for docking study on the basis of the criteria that they satisfied the Lipinski's Rule-of-Five...
January 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29291496/sensitive-and-rapid-determination-of-glyphosate-glufosinate-bialaphos-and-metabolites-by-uplc-ms-ms-using-a-modified-quick-polar-pesticides-extraction-method
#11
Hao Guo, Huijun Wang, Jing Zheng, Wenwen Liu, Jian Zhong, Qingbiao Zhao
Phosphoric acid-containing amino acid pesticides, including glyphosate, glufosinate, and bialaphos, have been frequently encountered in human poisoning and suicidal cases, thus a quick and sensitive determination method for these compounds is very important. Herein we report a sensitive and rapid method for the determination of glyphosate, glufosinate, bialaphos and their metabolites, aminomethylphosphonic acid (AMPA) and 3-methylphosphinicopropionic acid (MPPA) in human blood samples. The method involves extraction using a modified Quick Polar Pesticides Extraction (QuPPe) method, cleanup with the PRiME HLB sorbents and detection with ultra performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS)...
December 18, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29259829/antibacterial-activity-of-free-fatty-acids-from-hydrolyzed-virgin-coconut-oil-using-lipase-from-candida-rugosa
#12
Van Thi Ai Nguyen, Truong Dang Le, Hoa Ngoc Phan, Lam Bich Tran
Free fatty acids (FFAs) were obtained from hydrolyzed virgin coconut oil (VCO) by Candida rugosa lipase (CRL). Four factors' influence on hydrolysis degree (HD) was examined. The best hydrolysis conditions in order to get the highest HD value were determined at VCO to buffer ratio 1 : 5 (w/w), CRL concentration 1.5% (w/w oil), pH 7, and temperature 40°C. After 16 hours' reaction, the HD value achieved 79.64%. FFAs and residual hydrolyzed virgin coconut oil (HVCO) were isolated from the hydrolysis products...
2017: Journal of Lipids
https://www.readbyqxmd.com/read/29259210/efficient-direct-formic-acid-fuel-cells-dfafcs-anode-derived-from-seafood-waste-migration-mechanism
#13
Gumaa A El-Nagar, Mohamed A Hassan, Iver Lauermann, Christina Roth
Commercial Pt/C anodes of direct formic acid fuel cells (DFAFCs) get rapidly poisoned by in-situ generated CO intermediates from formic acid non-faradaic dissociation. We succeeded in increasing the Pt nanoparticles (PtNPs) stability and activity for formic acid oxidation (DFAFCs anodic reaction) by embedding them inside a chitosan matrix obtained from seafood wastes. Atop the commercial Pt/C, formic acid (FA) is predominantly oxidized via the undesired poisoning dehydration pathway (14 times higher than the desired dehydrogenation route), wherein FA is non-faradaically dissociated to CO resulting in deactivation of the majority of the Pt active-surface sites...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231019/-simultaneous-quantitative-analysis-of-koumine-gelsemine-and-gelsenicine-in-biological-samples-by-lc-ms-ms
#14
S J Ji, W Liu
OBJECTIVES: To establish a LC-MS/MS method which is accurate and sensitive for determination of koumine, gelsemine, and gelsenicine in biological samples and to verify the method. METHODS: Strychnine was used as internal standard. Analytes in blood, urine and liver with 1% sodium hydroxide solution were extracted by ethyl acetate. Chromatographic separation was achieved on a ZORBAX SB-C₁₈ column (150 mm×2.1 mm, 5 μm), and gradient elution was performed with the buffer solution of methanol-20 mmol/L ammonium acetate (including 0...
April 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29226783/evaluation-of-the-water-disinfection-by-product-dichloroacetonitrile-induced-biochemical-oxidative-histopathological-and-mitochondrial-functional-alterations-subacute-oral-toxicity-in-rats
#15
Ying Dong, Fang Li, Haijun Shen, Rongzhu Lu, Siqi Yin, Qi Yang, Zhuangfa Li, Suhua Wang
Dichloroacetonitrile (DCAN), an emerging nitrogenous disinfection by-product, is more genotoxic and cytotoxic than the currently regulated carbonaceous disinfection by-products such as haloacetic acids. Few mechanistic studies have been conducted on the hepatic and renal toxicities of DCAN. This study examined the clinical biochemical, hematological, histopathological, oxidative, and mitochondrial functional alterations to evaluate the systematic toxicity after subacute oral exposure of 11 or 44 mg/kg/day in rats for 28 days...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29223596/presence-and-persistence-of-the-amnesic-shellfish-poisoning-toxin-domoic-acid-in-octopus-and-cuttlefish-brains
#16
Vanessa M Lopes, Rui Rosa, Pedro R Costa
Domoic acid (DA) is a neurotoxin that causes degenerative damage to brain cells and induces permanent short-term memory loss in mammals. In cephalopod mollusks, although DA is known to accumulate primarily in the digestive gland, there is no knowledge whether DA reaches their central nervous system. Here we report, for the first time, the presence of DA in brain tissue of the common octopus (Octopus vulgaris) and the European cuttlefish (Sepia officinalis), and its absence in the brains of several squid species (Loligo vulgaris, L...
December 5, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29203541/nani-sialidase-can-support-the-growth-and-survival-of-clostridium-perfringens-strain-f4969-using-sialyated-host-macromolecules-mucin-or-caco-2-cells
#17
Jihong Li, Bruce A McClane
Enterotoxin-producing Clostridium perfringens type A strains cause human gastrointestinal (GI) infections, including a very common food poisoning and 5-10% of all antibiotic-associated diarrhea cases. This bacterium can utilize free sialic acid for growth but most sialic acids in the GI tract are sequestered on macromolecules such as the mucin proteins of mucus or glycoconjugates in host cells. However, many C. perfringens strains produce sialidases that might promote growth and survival by generating free sialic acid from those sialyated host macromolecules or by exposing underlying carbohydrates or proteins for digestion by other enzymes...
December 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29174400/self-assembled-monolayer-based-immunoassays-for-okadaic-acid-detection-in-seawater-as-monitoring-tools
#18
Sandra Leonardo, Anna Toldrà, Maria Rambla-Alegre, Margarita Fernández-Tejedor, Karl B Andree, Laura Ferreres, Katrina Campbell, Christopher T Elliott, Ciara K O'Sullivan, Yolanda Pazos, Jorge Diogène, Mònica Campàs
Rapid and cost-effective methods to monitor the presence of diarrhetic shellfish poisoning (DSP) toxins in seawater samples in an easy and reliable manner are required to protect human health and avoid economic losses to shellfish industry. Immunoassays for the detection of okadaic acid (OA) and dinophysistoxin-1 and dinophysistoxin-2 are developed by immobilising OA on self-assembled monothiols or dithiols in an ordered and oriented way, providing an effective limit of detection of ∼1 ng OA equiv./mL seawater...
November 14, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29164462/ameliorative-effect-of-the-anticancer-agent-salinomycin-on-cadmium-induced-hepatotoxicity-and-renal-dysfunction-in-mice
#19
Kalina Kamenova, Yordanka Gluhcheva, Ivelin Vladov, Silviya Stoykova, Juliana Ivanova
This study presents experimental data on the effects of the tetraethylammonium salt of salinomycinic acid (Sal) on Cd-induced hepatotoxicity and renal dysfunction in Cd-treated mice compared to those of meso-2,3-dimercaptosuccinic acid (DMSA). Forty 60-day-old male ICR mice were randomized into five groups: control group (untreated mice), Cd group (Cd(II) acetate 20 mg/kg body weight provided orally once per day for 14 days), Cd + DMSA group (exposed to Cd(II) acetate as the Cd-exposed group followed by DMSA 20 mg/kg body weight provided orally once per day for 14 days), and Cd + Sal group (exposed to Cd(II) acetate as the Cd-exposed group followed by Sal 20 mg/kg body weight once per day for 14 days)...
November 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29161647/simple-synthesis-of-self-supported-hierarchical-aupd-alloyed-nanowire-networks-for-boosting-electrocatalytic-activity-toward-formic-acid-oxidation
#20
Tao Yuan, Hong-Yan Chen, Xiaohong Ma, Jiu-Ju Feng, Pei-Xin Yuan, Ai-Jun Wang
Herein, self-supported hierarchical AuPd alloyed interconnected nanowire networks (AuPd NCNs) were fabricated by a one-pot co-reduction method. Theophylline was acted as the capping and structure-directing agents. The product was mainly characterized by a series of techniques such as transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The hierarchical nanostructures had the enlarged electrochemically active surface area (EASA), and the enhanced catalytic activity toward formic acid oxidation reaction (FAOR) and strengthened poisoning tolerance for poisoning CO-like intermediates by cyclic voltammetry and chronoamperometry, which outperformed commercial Pd black catalyst...
November 6, 2017: Journal of Colloid and Interface Science
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