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https://www.readbyqxmd.com/read/29452406/negative-association-between-sclerostin-and-insl3-in-isolated-human-osteocytes-and-in-klinefelter-syndrome-new-hints-for-testis-bone-crosstalk
#1
Andrea Di Nisio, Luca De Toni, Maria Santa Rocca, Marco Ghezzi, Riccardo Selice, Giuseppe Taglialavoro, Alberto Ferlin, Carlo Foresta
Context/Objective: The regulation of bone mass by the testis is a well-recognized mechanism, but the role of Leydig-specific marker insuline-like 3 peptide (INSL3) on the most abundant bone cell population, osteocytes, is unknown. In this study we aimed to investigate the relationship between INSL3 and Sclerostin, an osteocyte-specific protein that negatively regulates bone formation. Design/Setting: Serum sclerostin and INSL3 levels were evaluated in Klinefelter Syndrome (KS) and healthy controls...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29445830/bone-health-assessment-in-older-people-with-or-without-muscle-health-impairment
#2
M Locquet, C Beaudart, O Bruyère, J A Kanis, L Delandsheere, J-Y Reginster
This study investigated the relationship between muscle and bone status in elderly individuals. Our results suggested links between sarcopenia and osteoporosis; impairment in muscle status (i.e., muscle mass, muscle strength, and physical performance) is associated with deterioration in bone mass and texture subsequently leading to an increased risk of fracture. INTRODUCTION: Accumulating evidence has shown associations between sarcopenia and osteoporosis, but existing studies face inconsistencies in the clinical definition of both conditions...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29435946/ethnic-variations-in-adiponectin-levels-and-its-association-with-age-gender-body-composition-and-diet-differences-between-iranians-indians-and-europeans-living-in-australia
#3
Majid Meshkini, Fariba Alaei-Shahmiri, Cyril Mamotte, Jaya Dantas
Adiponectin is an adipocyte-derived protein with anti-diabetic, anti-atherogenic and anti-inflammatory action, but there are few studies on its association with cardiovascular and metabolic risk factors in different ethnic groups in Australia. This cross-sectional study evaluated ethnic differences in adiponectin levels and its association with age, gender, body composition and diet in 89 adult Australians of European (n = 28), Indian (n = 28) and Iranian (n = 33) ancestries. Different measures of adiposity were assessed using the method of whole body dual energy X-ray absorptiometry (DEXA)...
February 12, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29430607/the-fates-of-pedicle-screws-and-functional-outcomes-in%C3%A2-a-geriatric-population-following-polymethylmethacrylate-augmentation-fixation-for-the-osteoporotic-thoracolumbar-and-lumbar-burst-fractures-with-mean-ninety-five%C3%A2-month-follow-up
#4
Hsi-Hsien Lin, Ming-Chau Chang, Shih-Tien Wang, Chien-Lin Liu, Po-Hsin Chou
PURPOSE: Polymethylmethacrylate (PMMA) augmentation is a common method to increase pullout strength fixed for osteoporotic spines. However, few papers evaluated whether these pedicle screws migrated with time and functional outcome in these geriatrics following PMMA-augmented pedicle screw fixation. METHODS: From March 2006 to September 2008, consecutive 64 patients were retrospectively enrolled. VAS and ODI were used to evaluate functional outcomes. Kyphotic angle at instrumented levels and horizontal and vertical distances (HD and VD) between screw tip and anterior and upper cortexes were evaluated...
February 11, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29430497/evaluation-of-bone-mineral-density-in-perimenopausal-period
#5
Zhaleh Shariati-Sarabi, Hamid Etemad Rezaie, Nasrin Milani, Farnaz Etemad Rezaie, Ali Etemad Rezaie
Background: The menopausal transition called perimenopause, happens after the reproductive years, and is specified with irregular menstrual cycles, perimenopause symptoms and hormonal changes. Women going through peri menopausal period are vulnerable to bone loss . Osteoporosis is one of the most common debilitating metabolic bone diseases, especially in the women almost around 50 years. This study was intended to evaluate the prevalence of osteopenia/osteoporosis amongst asymptomatic individuals during the menopause transition period...
January 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29426839/association-of-muscle-mass-and-fat-mass-with-insulin-resistance-and-the-prevalence-of-metabolic-syndrome-in-korean-adults-a-cross-sectional-study
#6
Kyuwoong Kim, Sang Min Park
Relationship of muscle mass and fat mass with insulin resistance and metabolic syndrome remains uncertain, especially among Asian population. We performed a cross-sectional study with 14,807 adult participants aged between 18 and 65 in the fourth and fifth Korea National Health and Nutrition Examination Survey with Dual Energy X-ray Absorptiometry (DEXA) data to investigate whether muscle mass and fat mass are associated with insulin resistance and metabolic syndrome. DEXA records were used to categorize the participants into four categories (low muscle/low fat, low muscle/high fat, high muscle/ low fat, and high muscle/high fat)...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425753/effects-of-rhbmp-2-7-heterodimer-and-rada16-hydrogel-scaffold-on-bone-formation-during-rabbit-mandibular-distraction
#7
Ling-Fei Ren, Geng-Sheng Shi, Yong-Qing Tong, Song-Yao Jiang, Feng Zhang
PURPOSE: The effects of a recombinant human bone morphogenetic protein-2/7 (rhBMP-2/7) heterodimer and a RADA16 (Ac-RADARADARADARADA-CONH2) hydrogel scaffold on bone formation during distraction osteogenesis were evaluated. MATERIALS AND METHODS: Forty New Zealand white rabbits, which underwent mandibular lengthening, were randomly divided into 5 groups. One group served as the control group. The others received 2 μg of rhBMP-2 homodimer, 2 μg of rhBMP-2/7 heterodimer, 100 μL of RADA16, or 100 μL of RADA16 plus 2 μg of rhBMP-2/7 heterodimer in the mandibular distraction gap at the beginning of distraction...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29425469/discordance-between-body-mass-index-bmi-and-a-novel-body-composition-change-index-bcci-as-outcome-measures-in-weight-change-interventions
#8
Stephen D Nugent, Gilbert R Kaats, Harry G Preuss
OBJECTIVE: A general assumption is that the body mass index (BMI) reflects changes in fat mass (FM). However, it fails to distinguish the type of weight that is lost or gained-fat mass (FM) or fat-free mass (FFM). The BMI treats both changes the same although they have opposite health consequences. The objective of this study was to propose a more precise measure, a body composition change index (BCCI), which distinguishes between changes in FM and FFM, and this study compares it with using the BMI as an outcome measure...
February 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29416583/assessment-of-serum-vitamin-b12-levels-and-other-metabolic-parameters-in-subjects-with-different-values-of-bone-mineral-density
#9
Marianna Renis, Debora Lobreglio, Pierpaolo Congedo, Maria Concetta Montinaro, Maurizio Muratore, Giambattista Lobreglio
Background: Controversial experimental and clinical evidences have raised questions regarding the role of B12 and insulin-like growth factor 1 (IGF-1) on osteoblast function and bone health. In this study, we aimed to determine if the serum levels of B12, IGF-1 and procollagen type 1 N-terminal propeptide (P1NP) are associated with different degrees of bone mineral density (BMD). Methods: A total of 287 subjects (190 women and 97 men; mean age 53 years) volunteered for evaluation of BMD and serum levels of B12, IGF-1 and P1NP; BMD at lumbar spine and proximal femur was evaluated by means of dual-energy X-ray absorption (DEXA) and expressed as T-score; serum concentrations of vitamin B12 and IGF1 were measured with a chemiluminescent immunoassay on Access II Beckman Coulter and DiaSorin Liaison XL analyzers, respectively; P1NP was assessed in 61 women and 35 men with reduced T-score on Roche Modular platform...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29412289/calf-circumference-clinical-validation-for-evaluation-of-muscle-mass-in-the-elderly
#10
Valéria Pagotto, Kássylla Ferreira Dos Santos, Suelen Gomes Malaquias, Maria Márcia Bachion, Erika Aparecida Silveira
OBJECTIVE: To validate calf circumference as a technology for assessing muscle mass in the elderly. METHOD: Cross-sectional study with 132 elderly people from Goiânia, Goiás, Brazil. Decreased muscle mass was determined by the skeletal muscle mass index (IME) using Dual Energy X-Ray Absortometry (DEXA). The cutoff circumferences (CC) cutoff points to indicate muscle mass decrease were estimated by ROC curve, sensitivity, specificity and accuracy. RESULTS: The most accurate cut-off points for detecting decreased muscle mass in the elderly were 34 cm for men (sensitivity: 71...
March 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29401540/eighteen-year-effect-of-androgen-therapy-on-bone-mineral-density-in-trans-gender-men
#11
Petr Dan Broulik, Václav Urbánek, Petr Libanský
The study explores the influence of long-term androgen supplementation (18 years) on bone metabolism in trans(gender) men. Thirty five trans(gender) men aged (47±4) were treated with adequate dose of testosterone. BMD was measured by DEXA at lumbar spine and neck and T score was determined. Biochemical parameters of bone turnover were measured in all patients. As compared with female and male age matched controls they showed a not significantly different T-score at spine [1.213±0.15 in trans(gender) men vs...
February 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29398518/hyperemesis-gravidarum-is-not-a-negative-contributing-factor-for-postpartum%C3%A2-bone-mineral-density
#12
Gulsum Uysal, Fulya Cagli, Hatice Akkaya, Hakan Nazik, Cigdem Karakukcu, Serap Sutbeyaz, Esra S Yilmaz
BACKGROUND: Hyperemesis gravidarum (HG), related to protracted vomiting and nausea, is a common cause of hospitalization during the first trimester of pregnancy. It can be accompanied by ketonuria, dehydration, and weight loss. Our aim was to investigate bone loss in patients with HG. METHODS: In our study, we investigated decreased bone mineral density (BMD)in a total of 79 patients (40 HG and 39 control) by means of dual energy X-ray absorptiometry (DEXA) measurements and laboratory parameters related to HG...
February 1, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29394971/role-of-weight-bearing-exercises-in-the-treatment-of-post-menopausal-osteoporosis
#13
Shazia Rafiq, Sobia Zia, Muhammad Junaid Ijaz, Hassan Anjum Shahid, Muhammad Adeel
OBJECTIVE: To determine the change in T-score of post-menopausal osteoporosis patients with weight-bearing exercises. STUDY DESIGN: A quasi-experimental study. PLACE AND DURATION OF STUDY: Physiotherapy Department and Orthopedic Unit I, Mayo Hospital, Lahore, from May to October 2014. METHODOLOGY: Two hundred and seventy-four patients were randomly divided into two groups according to inclusion and exclusion criteria using non-probability purposive sampling technique...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29383454/increased-frequency-of-temporal-acoustic-window-failure-in-rheumatoid-arthritis-a-manifestation-of-altered-bone-metabolism
#14
Zsófia Kardos, Csaba Oláh, Mariann Sepsi, Attila Sas, László Kostyál, Tünde Bóta, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Dániel Bereczki, Zoltán Szekanecz
Assessment of intracranial vessels includes transcranial Doppler (TCD). TCD performance requires intact temporal acoustic windows (TAW). Failure of TAW (TAWF) is present in 8-20% of people. There have been no reports on TAWF in rheumatoid arthritis (RA). Altogether, 62 female RA patients were included. Among them, 20 were MTX-treated and biologic-free, 20 received infliximab, and 22 tocilizumab. The controls included 60 non-RA women. TAWF, temporal bone thickness, and texture were determined by ultrasound and CT...
January 30, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29380855/single-arm-resistance-training-study-to-determine-the-relationship-between-training-outcomes-and-muscle-growth-factor-mrnas-in-older-adults-consuming-numerous-medications-and-supplements
#15
R A Dennis, K K Garner, P M Kortebein, C M Parkes, M M Bopp, S Li, K P Padala, P R Padala, D H Sullivan
OBJECTIVES: Determine if the muscle mRNA levels of three growth factors (insulin-like growth factor-1 [IGF1], ciliary neurotropic factor [CNTF], and vascular endothelial growth factor-D [VEGFD]) are correlated with muscle size and strength gains from resistance exercise while piloting a training program in older adults taking medications and supplements for age-associated problems. DESIGN: Single-arm prospective study. SETTING: US Veterans Affairs hospital...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29379565/bone-mineral-density-and-bone-metabolism-in-patients-with-duchenne-muscular-dystrophy
#16
Mohammad Barzegar, Elnaz Niknam, Parinaz Habibi, Shadi Shiva, Sanaz Tahmasebi
Objective: Poor bone health with related morbidity is a major problem with Duchene Muscular Dystrophy (DMD). Decreased mobility and long-term corticosteroid therapy are involved in poor bone health in DMD. We investigated bone mineral density and bone metabolism in 30 steroid treated DMD patients and also compared mentioned factors between ambulated and non-ambulated patients. Materials & Methods: In this cross-sectional study, 30 boys (21 patients ambulate and 9 non-ambulate) with documented DMD, according to genetic analysis, were enrolled in 2015...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29368309/are-we-treating-osteoporotic-fractures-of-the-hip-adequately-a-middle-eastern-cohort-study
#17
K Venugopal Menon, Huda Hamed Salim Al Harthy, Khalid Shafi Khalid Al Habsi, Hind Abdullah Hamed Al Ruzaiqi
Fragility hip fractures treated in a center in the Middle East were retrospectively studied for adequacy of osteoporosis management. Of the 318 patients treated, over 70% did not have a structured investigation and about 30% did not receive any therapeutic supplements. Our series showed a preventable 8.8% secondary fracture rate. PURPOSE: To study the adequacy of evaluation and treatment of osteoporosis after fragility fractures of the hip. The study also attempts to estimate the prevalence of secondary fractures after the original injury...
January 24, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29352218/nutritional-deficiencies-and-bone-metabolism-after-endobarrier-in-obese-type-2-patients-with-diabetes
#18
Nuria Vilarrasa, Alexandra Fabregat, Silvia Toro, Amador García Gordejuela, Anna Casajoana, Mónica Montserrat, Pilar Garrido, Rafael López-Urdiales, Núria Virgili, Alejandra Planas-Vilaseca, Andreu Simó-Servat, Jordi Pujol
Endobarrier® is a minimally invasive, reversible endoscopic treatment for obesity. It provokes malabsorption along 60 cm of the small intestine, which can contribute to the development of vitamin deficiencies and to changes in bone mineral density (BMD). To determine the prevalence of nutrient deficiencies, changes in body composition and BMD during the first year after Endobarrier® placement. Twenty-one patients with type 2 diabetes met inclusion criteria. Levels of vitamins, micro and macronutrients were assessed prior and at 1, 3 and 12 months post-operatively...
January 19, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29344033/investigating-the-prevalence-of-low-bone-mass-in-children-of-southern-iran-and-its-associated-factors
#19
Forough Saki, Gholamhossein Ranjbar Omrani, Marjan Jeddi, Marzie Bakhshaieshkaram, Mohammad Hossein Dabbaghmanesh
Background: Improving peak bone mass and bone strength in the first years of life and enhancing it during young adulthood could prevent osteoporosis and fractures in the last years of life. We evaluated the prevalence of low bone mass in the lumbar and femoral neck and its associated factors in southern Iranian children. Methods: This is a cross-sectional study on healthy Iranian children aged 9 - 18 years old during 2011 - 2012. Dual energy X-ray absorptiometry (DEXA) was used for measuring bone mineral density (BMD)...
October 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29339988/impact-of-futsal-and-swimming-participation-on-bone-health-in-young-athletes
#20
André Seabra, Ricardo J Fernandes, Elisa Marques, Miguel Moura, Esther Ubago-Guisado, Enrique Hernando, Leonor Gallardo
Physical activity plays a crucial role in bone mass acquisition during childhood and adolescence, with weightbearing and high-impact sport activities being more beneficial. This study sought to evaluate the impact of different sports activities on bone mineral density and content in male Portuguese athletes. Seventy adolescent boys (aged 12-15 years) including 28 futsal players (FG), 20 swimmers (SG) and 22 non-athletic adolescents used as control subjects (CG), participated in the current study. Areal bone mineral density (aBMD) and areal bone mineral content (aBMC) were measured by dual energy x-ray absorptiometry (DEXA)...
December 2017: Journal of Human Kinetics
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