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https://www.readbyqxmd.com/read/28428669/risk-factors-for-osteoporosis-in-postmenopausal-women
#1
Radojka Bijelic, Snjezana Milicevic, Jagoda Balaban
INTRODUCTION: Scientific studies show that many factors related to lifestyles affect the reduction of bone mineral density and osteoporosis in postmenopausal women. GOAL: The goal of this study was to determine whether smoking, drinking coffee and alcohol in menopausal women contribute to the reduction of bone mass and osteoporosis, as well as the impact of physical activity on bone mass. MATERIAL AND METHODS: The study was carried out as case study and matched controls...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28416437/the-ct-based-fractal-analysis-of-trabecular-bone-structure-may-help-in-detecting-decreased-quality-of-bone-prior-to-urgent-spinal-procedures
#2
Marcin Czyz, Arion Kapinas, James Holton, Renata Pyzik, Bronek M Boszczyk, Nasir A Quraishi
BACKGROUND CONTEXT: To date no reliable method is available to determine the parameters of bone density based on the routine spinal CT in the emergency setup. We propose the use of fractal analysis to detect patients with poor quality of bone prior to urgent or semi-urgent spinal procedures. PURPOSE: To validate the hypothesis that the CT-based fractal analysis of the trabecular bone structure may help in detecting patients with poor quality of bone prior to urgent spinal procedures...
April 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28410836/low-preoperative-bmd-is-related-to-high-migration-of-tibia-components-in-uncemented-tka-92-patients-in-a-combined-dexa-and-rsa-study-with-2-year-follow-up
#3
Mikkel R Andersen, Nikkolaj S Winther, Thomas Lind, Henrik M Schrøder, Gunnar Flivik, Michael M Petersen
BACKGROUND: The fixation of uncemented tibia components in total knee arthroplasty may rely on the bone quality of the tibia; however, no previous studies have shown convincing objective proof of this. Component migration is relevant as it has been shown to predict aseptic loosening. METHODS: We performed 2-year follow-up of 92 patients who underwent total knee arthroplasty surgery with an uncemented tibia component. Bone mineral density (BMD; g/cm(2)) of the tibia host bone was measured preoperatively using dual energy X-ray absorptiometry...
February 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28401118/frequency-of-and-variation-in-low-value-care-in-primary-care-a-retrospective-cohort-study
#4
Ciara Pendrith, Meghan Bhatia, Noah M Ivers, Graham Mecredy, Karen Tu, Gillian A Hawker, Susan B Jaglal, Lynn Wilson, Kimberly Wintemute, Richard H Glazier, Wendy Levinson, R Sacha Bhatia
BACKGROUND: Low-value care, defined as care with a lack of benefit, can lead to higher health care costs, inconvenience to patients and, in some cases, harm to patients. The objectives of this study are to conduct exploratory analyses to understand how frequently selected low-value tests are ordered, to assess the degree of variation in ordering that exists across regions and practices, and to identify services that may warrant further investigation and targeted interventions. METHODS: We conducted a population-based retrospective cohort study using administrative health care databases from Ontario to identify rates of use of the following low-value services between fiscal years 2008/09 and 2012/13: computed tomography (CT) or magnetic resonance imaging (MRI) after a diagnosis of low back pain, Papanicolaou testing in women less than 21 years of age or older than 69 years of age and repeated dual-energy X-ray absorptiometry (DEXA) scanning within 2 years of an index scan...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28390555/a-snapshot-of-patients-awareness-of-radiation-dose-and-risks-associated-with-medical-imaging-examinations-at-an-australian-radiology-clinic
#5
N Singh, A Mohacsy, D A Connell, M E Schneider
BACKGROUND: Cumulative radiation exposure is linked to increasing the lifetime attributable risk of cancer. To avoid unnecessary radiation exposure and facilitate shared decision making, patients should be aware of these issues. This paper examines patients' awareness of radiation dose and risks associated with medical imaging examinations. METHODS: Consecutive patients attending a private radiology clinic over a nine week period in 2014 in Metropolitan Melbourne were surveyed while waiting to undergo an imaging examination...
May 2017: Radiography
https://www.readbyqxmd.com/read/28387962/comparative-investigation-of-bone-mineral-density-using-ct-and-dexa-in-a-canine-femoral-model
#6
Karin Lucas, Bernd-Arno Behrens, Ingo Nolte, Vladimir Galindo-Zamora, Stefanie Betancur, Amer Almohallami, Anas Bouguecha, Ayman Mostafa, Matthias Lerch, Christina Stukenborg-Colsman, Patrick Wefstaedt
Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a corrrelation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature...
April 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28382607/frailty-and-primary-sarcopenia-a-review
#7
Eli Carmeli
Increasing longevity, coupled with rising frailty and sarcopenia of aging, significantly affects function and quality of life of older adults. This review discusses the definition, assessment, and management of frailty and sarcopenia, and examines the relationship between them. Medline, Scopus and Psychoinfo databases were searched using the keywords frailty, sarcopenia, aging, and functional disability. The findings are that frailty and sarcopenia are often assessed clinically with such methods such as DeXA, CT scan, MRI, bioelectrical impedance, or anthropometry...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28368024/higher-glomerular-filtration-rate-is-related-to-insulin-resistance-but-not-to-obesity-in-a-predominantly-obese-non-diabetic-cohort
#8
Negar Naderpoor, Jasmine G Lyons, Aya Mousa, Sanjeeva Ranasinha, Maximilian P J de Courten, Georgia Soldatos, Barbora de Courten
Glomerular hyperfiltration has been associated with obesity, insulin resistance, and systolic blood pressure (SBP). However, previous studies are limited by confounders such as pre-existing diabetes or hypertension, or have used indirect measures of adiposity and insulin sensitivity (IS). Therefore, we examined the relationship between estimated glomerular filtration rate (eGFR) and IS measured by the hyperinsulinaemic euglycaemic clamp in a healthy population on no medications. We performed oral glucose tolerance test (OGTT) and measured % body fat (DEXA), BMI, blood pressure and M-value (hyperinsulinaemic euglycaemic clamp) in 104 individuals (44 females and 60 males)...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28362048/comparison-of-estimates-of-resting-energy-expenditure-equations-in-haemodialysis-patients
#9
Rachel Hung, Sivakumar Sridharan, Ken Farrington, Andrew Davenport
PURPOSE: Waste products of metabolism accumulate in patients with chronic kidney disease, and require clearance by haemodialysis (HD). We wished to determine whether there was an association between resting energy expenditure (REE) and total energy expenditure (TEE) in HD patients and body composition. SUBJECTS/METHODS: We determined REE by recently validated equations (CKD equation) and compared REE with that estimated by standard equations for REE, and TEE calculated from patient reported physical activity, in HD patients with corresponding body composition measured by dual energy X-ray absorptiometry (DEXA) scanning...
March 27, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28358805/fasting-regulates-egr1-and-protects-from-glucose-and-dexamethasone-dependent-sensitization-to-chemotherapy
#10
Stefano Di Biase, Hong Seok Shim, Kyung Hwa Kim, Manlio Vinciguerra, Francesca Rappa, Min Wei, Sebastian Brandhorst, Francesco Cappello, Hamed Mirzaei, Changhan Lee, Valter D Longo
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, elevate glucose and sensitize cardiomyocytes and mice to the cancer drug doxorubicin (DXR). Such toxicity can be reversed by reducing circulating glucose levels by fasting or insulin. Furthermore, glucose injections alone reversed the fasting-dependent protection against DXR in mice, indicating that elevated glucose mediates, at least in part, the sensitizing effects of rapamycin and dexamethasone...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28358295/body-adiposity-index-but-not-visceral-adiposity-index-correlates-with-inflammatory-markers-in-sarcopenic-obese-elderly-women
#11
Maurílio Tiradentes Dutra, André Bonadias Gadelha, Otávio Toledo Nóbrega, Ricardo Moreno Lima
Background/Study Context: The association of body adiposity index (BAI) and visceral adiposity index (VAI) with inflammatory markers has yet to be understood. The aim of this work was to investigate the association of BAI and VAI with inflammatory markers in elderly women with sarcopenic obesity (SO). METHODS: A total of 130 women (age: 66.7 ± 5.2 years) underwent body composition analysis by dual-energy x-ray absorptiometry (DEXA). Volunteers were classified according to SO definition...
May 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28345842/bone-mineral-density-in-survivors-of-childhood-acute-lymphoblastic-leukemia
#12
Farzaneh Rohani, Khadijeh Arjmandi Rafsanjani, Gholamreza Bahoush, Mansoureh Sabzehparvar, Mohammad Ahmadi
Background: The objective of this study was to evaluate bone mineral density (BMD) after completion of treatment for childhood acute lymphoblastic leukemia (ALL). Methods: In this cross-sectional study, 103 survivors of ALL aged 13.5 ± 0.45 who completed their treatment at least one year earlier were enrolled. Among these, 49.5% and 51.5% received chemotherapy alone and chemotherapy plus cranial radiotherapy, respectively. Bone mineral content, BMD, and bone mineral apparent density in the lumbar spine (LS), femoral neck (FN) and forearm were assessed using dual-energy X-ray absorptiometry (DEXA)...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28341925/relationship-between-serum-adiponectin-and-bone-mineral-density-in-male-patients-with-obstructive-sleep-apnea-syndrome
#13
Dong-Dong Chen, Jie-Feng Huang, Qi-Chang Lin, Gong-Ping Chen, Jian-Ming Zhao
PURPOSE: Obstructive sleep apnea syndrome (OSAS) is reported to have an association with bone mineral density (BMD). However, the underlying mechanism is far from clear. The aim of this study was to investigate the relationship between OSAS, bone turnover markers, and BMD and to evaluate the effect of adiponectin on BMD in patients with OSAS. METHODS: Seventy-one male patients with OSAS and 13 male control subjects were enrolled in this study. Serum adiponectin, calcium, phosphorus, 25-hydroxyvitamin-D3, β-isomerized form C-terminal telopeptide of type I collagen, osteocalcin, and procollagen type 1 N-propeptide were measured in all subjects, and BMD was evaluated by dual-energy X-ray absorptiometry (DEXA) in the lumbar spine (L1-L4), the femoral neck, and the hip total...
March 25, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28341259/effect-of-vitamin-d-supplementation-and-isokinetic-training-on-muscle-strength-explosive-strength-lean-body-mass-and-gait-in-severely-burned-children-a-randomized-controlled-trial
#14
Anwar Abdelgayed Ebid, Shamekh Mohamed El-Shamy, Maysa Abbas Amer
OBJECTIVE: To determine the effects of vitamin D (VD) supplementation and isokinetic training on muscle strength, explosive strength (counter movement jump) (ES), lean body mass (LBM) and gait parameters in severe pediatric burn. METHODS: Forty-eight burned children with circumferential lower extremity burns covering 40-55% of the total body surface area (TBSA), aged 10-16 years (Mean±SD 13.01±1.75), were randomized into the standard of care (n=16), isokinetic (n=17) and VD (n=15) groups...
March 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28340152/sarcopenia-and-relationships-between-muscle-mass-measured-glomerular-filtration-rate-and-physical-function-in-patients-with-chronic-kidney-disease-stages-3-5
#15
Yunan Zhou, Matthias Hellberg, Philippa Svensson, Peter Höglund, Naomi Clyne
Background.: Sarcopenia and poor physical function are common in patients with chronic kidney disease (CKD). Our aim was to investigate the relationships between muscle mass and measured glomerular filtration rate (GFR) and between muscle mass and strength and balance, respectively, in patients with CKD stages 3-5. Methods.: This is a baseline data analysis of a randomized controlled clinical trial. A total of 148 adult patients with an estimated GFR <30 mL/min/1...
March 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28325584/development-of-a-surrogate-model-based-on-patient-weight-bone-mass-and-geometry-to-predict-femoral-neck-strains-and-fracture-loads
#16
Mark Taylor, Egon Perilli, Saulo Martelli
Osteoporosis and related bone fractures are an increasing global burden in our ageing society. Areal bone mineral density assessed through dual energy X-ray absorptiometry (DEXA), the clinically accepted and most used method, is not sufficient to assess fracture risk individually. Finite element (FE) modelling has shown improvements in prediction of fracture risk, better than aBMD from DEXA, but is not practical for widespread clinical use. The aim of this study was to develop an adaptive neural network (ANN)-based surrogate model to predict femoral neck strains and fracture loads obtained from a previously developed population-based FE model...
April 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28318333/urinary-levels-of-pyridinoline-and-deoxypyridinoline-and-bone-mineral-density-in-children-with-type-1-diabetes-mellitus
#17
Nadide Melike Sav, Mustafa Kendirci, Leyla Akin, Selim Kurtoglu
OBJECTIVE: There is still controversy over the impact of diabetes mellitus (DM) on bone mass in children. Pyridinoline (Pyr) and deoxypyridinoline (DPyr), which stabilize the collagen chains within the extracellular matrix, are known as specific bone turnover markers. The aim of this study was to investigate the relationship between urinary Pyr and DPyr excretions and bone mineral density (BMD) in children with type 1 DM. METHODS: Serum levels of Ca, phosphorus (P), magnesium (Mg), and parathormone (PTH), alkaline phosphatase (ALP) activity, and urinary excretions of Pyr and DPyr were evaluated in 50 diabetic and 130 healthy control subjects aged between 7 and 15 years...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28277592/evaluation-of-the-effects-of-the-metha-short-stem-on-periprosthetic-bone-remodelling-in-total-hip-arthroplasties-results-at-48-months
#18
Paolo D Parchi, Gianluca Ciapini, Iacopo Castellini, Claudia Mannucci, Anna Maria Nucci, Nicola Piolanti, Silvia Maffei, Michele Lisanti
INTRODUCTION: Total hip arthroplasty is one of the most performed procedures in orthopaedic surgery. Implantation of a prosthesis determines changes in the distribution of loads on the host bone, and this phenomenon, known as stress shielding, is related to the biomechanical characteristics of the implant. Usually stress shielding involves the proximal portion of the femur by reducing the mechanical strength and ability to withstand the transmitted loads. The aim of our study is to demonstrate how the use of a short hip stem reduces the stress shielding phenomenon to the proximal femur...
March 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28277077/effect-of-low-levels-of-dietary-available-phosphorus-on-phosphorus-utilization-bone-mineralization-phosphorus-transporter-mrna-expression-and-performance-in-growing-pigs
#19
Bishwo B Pokharel, Alemu Regassa, Charles M Nyachoti, Woo K Kim
A study was conducted to examine the effects of different dietary levels of available phosphorus (aP) on P excretion, bone mineralization, performance and the mRNA expression of sodium-dependent P transporters in growing pigs. Sixty-day old growing pigs (n = 54) with an average initial BW of 19.50 ± 1.11 kg were randomly allocated to a control diet (C) containing 0.23% available phosphorus (aP), T1 containing 0.17% aP and T2 containing 0.11% aP. There were 6 pens per treatment with 3 pigs per pen. Body weight and feed intake were measured weekly...
March 3, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28271457/insulin-growth-factor-1-correlates-with-higher-bone-mineral-density-and-lower-inflammation-status-in-obese-adult-subjects
#20
Rachele Fornari, Chiara Marocco, Davide Francomano, Simona Fittipaldi, Carla Lubrano, Viviana M Bimonte, Lorenzo M Donini, Emanuele Nicolai, Antonio Aversa, Andrea Lenzi, Emanuela A Greco, Silvia Migliaccio
PURPOSE: Obesity is a severe public health problem worldwide, leading to an insulin-resistant state in liver, adipose, and muscle tissue, representing a risk factor for type 2 diabetes mellitus, cardiovascular diseases, and cancer. We have shown that abdominal obesity is associated with homeostasis derangement, linked to several hormonal and paracrine factors. Data regarding potential link between GH/IGF1 axis, bone mineral density, and inflammation in obesity are lacking. Thus, aim of this study was to evaluate correlation among IGF-1, BMD, and inflammation in obese individuals...
March 7, 2017: Eating and Weight Disorders: EWD
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