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https://www.readbyqxmd.com/read/29662664/regulation-of-the-antiapoptotic-protein-cflip-by-the-glucocorticoid-dexamethasone-in-all-cells
#1
Lara Kleinesudeik, Katharina Rohde, Simone Fulda
We recently reported that the Smac mimetic BV6 and glucocorticoids, e.g. Dexamethasone (Dexa), synergize to induce cell death in acute lymphoblastic leukemia (ALL) in vitro and in vivo . Here, we discover that this synergism involves Dexa-stimulated downregulation of cellular FLICE-like inhibitory protein (cFLIP) in ALL cells. Dexa rapidly decreases cFLIPL protein levels, which is further enhanced by addition of BV6. While attenuating the activation of non-canonical nuclear factor-kappaB (NF-κB) signaling by BV6, Dexa suppresses cFLIPL protein but not mRNA levels pointing to a transcription-independent downregulation of cFLIPL by Dexa...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29642478/diagnostic-criteria-and-clinical-outcomes-in-sarcopenia-research-a-literature-review
#2
REVIEW
Alex Han, Steven L Bokshan, Stephen E Marcaccio, J Mason DePasse, Alan H Daniels
By the sixth decade of life, nearly one quarter of the population has substantial muscle atrophy, or sarcopenia. Despite the creation of a standardized definition of sarcopenia by the European Working Group on Sarcopenia in Older People, variability may exist in the diagnostic criteria utilized for clinical sarcopenia research. The primary objectives of this review were to characterize diagnostic criteria used for measurement of sarcopenia in original studies, and to describe associations between sarcopenia and important clinical outcomes...
April 8, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29630136/body-fat-changes-in-hiv-patients-on-highly-active-antiretroviral-therapy-haart-a-longitudinal-dexa-study
#3
S Nuvoli, G Caruana, S Babudieri, P Solinas, G Pellicanò, B Piras, V Fiore, P Bagella, G M Calia, M Yue, A Spanu, G Madeddu
OBJECTIVE: We aimed to quantitatively evaluate body fat composition in a group of HIV patients treated with Highly Active Anti-retroviral Therapy (HAART) to ascertain both fat loss and fat distribution changes and to identify possible therapeutic and host related associated risk factors. PATIENTS AND METHODS: A total of 180 patients with available total body DEXA scan were assigned to a) Group 1, with clinically evident body fat changes, (BFC) and b) Group 2, without BFC...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29623244/the-relationship-between-bone-mineral-density-and-cardiovascular-function-in-duchenne-muscular-dystrophy-a-retrospective-cohort-study
#4
Tara Kervin, Mathula Thangarajh
INTRODUCTION: Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder that causes progressive skeletal and cardiac muscle weakness in boys. Cardiac dysfunction is a frequent cause of death in DMD. Glucocorticoids are the standard of care in DMD. The long-term use of oral glucocorticoids in DMD is complicated by poor bone health. Epidemiological studies suggest a biological link between the loss of bone mineral density (BMD) and cardiovascular disease, including coronary artery and cerebrovascular diseases...
March 22, 2018: PLoS Currents
https://www.readbyqxmd.com/read/29610677/potential-association-of-lmna-associated-generalized-lipodystrophy-with-juvenile-dermatomyositis
#5
Melis Sahinoz, Shafaq Khairi, Ashley Cuttitta, Graham F Brady, Amit Rupani, Rasimcan Meral, Marwan K Tayeh, Peedikayil Thomas, Meredith Riebschleger, Sandra Camelo-Piragua, Jeffrey W Innis, M Bishr Omary, Daniel E Michele, Elif A Oral
Background: Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and muscle weakness. At least 10% of the patients with JDM present with acquired lipodystrophy. Laminopathies are caused by mutations in the lamin genes and cover a wide spectrum of diseases including muscular dystrophies and lipodystrophy. The p.T10I LMNA variant is associated with a phenotype of generalized lipodystrophy that has also been called atypical progeroid syndrome...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29608596/proteomics-and-transcriptomics-analyses-of-ataxia-telangiectasia-cells-treated-with-dexamethasone
#6
Michele Menotta, Sara Orazi, Anna Maria Gioacchini, Chiara Spapperi, Anastasia Ricci, Luciana Chessa, Mauro Magnani
Ataxia telangiectasia (A-T) is an incurable and rare hereditary syndrome. In recent times, treatment with glucocorticoid analogues has been shown to improve the neurological symptoms that characterize this condition, but the molecular mechanism of action of these analogues remains unknown. Hence, the aim of this study was to gain insight into the molecular mechanism of action of glucocorticoid analogues in the treatment of A-T by investigating the role of Dexamethasone (Dexa) in A-T lymphoblastoid cell lines...
2018: PloS One
https://www.readbyqxmd.com/read/29607946/clinical-characteristics-phenotype-of-lipodystrophy-and-a-genetic-analysis-of-six-diabetic-japanese-women-with-familial-partial-lipodystrophy-in-a-diabetic-outpatient-clinic
#7
Masanori Iwanishi, Jun Ito-Kobayashi, Miki Washiyama, Toru Kusakabe, Ken Ebihara
Objective Our aim was to examine the clinical characteristics and phenotype of lipodystrophy of six diabetic Japanese women with partial lipodystrophy (PL) who received a genetic analysis at a diabetic outpatient clinic. Methods We screened for PL using dual energy X-ray absorptiometry (DEXA) and magnetic resonance imaging (MRI) among patients who had a reduced peripheral skinfold thickness at the diabetic outpatient clinic of Kusatsu General Hospital between August 2003 and August 2013. We performed a mutation analysis of candidate genes, including LMNA and PPARG, in two patients with PL and whole-exome sequencing in four patients with PL...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29593654/ethnic-disparities-in-endothelial-function-and-its-cardiometabolic-correlates-the-pathobiology-of-prediabetes-in-a-biracial-cohort-study
#8
Ibiye Owei, Nkiru Umekwe, Hanan Mohamed, Sotonte Ebenibo, Jim Wan, Sam Dagogo-Jack
Background: Endothelial function (EF) reflects the balance between vasodilatory and vasoconstrictive factors produced by (or acting on) the innermost lining of blood vessels. Endothelial dysfunction, an imbalance between these factors that favors vasoconstriction, has been associated with increased risk for cardiovascular disease. However, the influence of race/ethnicity and glycemic status on association between EF and cardiovascular risk factors remain to be clarified. Subjects and methods: We assessed EF in relation to glycemia and cardiometabolic profile in African-American (AA) and European-American (EA) offspring of parents with type 2 diabetes (T2D), who are participants in the prospective pathobiology and reversibility of prediabetes in a biracial cohort (PROP-ABC) study...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29578194/effect-of-bone-bank-processing-on-bone-mineral-density-histomorphometry-biomechanical-strength-of-retrieved-femoral-head
#9
O P Lakhwani, M Jindal, Omkar Kaur, R K Chandoke, S K Kapoor
Background & objectives: Standard processing of the bone grafts involves deep-freezing and sterilization with gamma irradiation which may alter mechanical properties of the bone graft. This study was aimed at measuring the effect of bone bank processing on the mechanical properties of bone allograft and its correlation with bone mineral density [BMD, dual-energy X-ray absorptiometry (DEXA Scan)] and histomorphometric indices. Methods: Femoral heads retrieved from patients undergoing hip replacement surgeries were used as the material...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29575883/relationships-between-bone-mineral-density-and-new-indices-of-body-composition-in-young-sedentary-men-and-women
#10
Anna Kęska, Grażyna Lutosławska, Jerzy Bertrandt, Małgorzata Sobczak
INTRODUCTION: Data concerning the relationship between body fat and BMD are equivocal since both positive and negative effects have been noted. Recently, the index of fat mass (IFM) representing subjects with different body fat and similar lean mass and index of lean mass (ILM) representing subjects with different lean body mass and similar body fat, have been used to evaluate body composition effect on BMD in middle-aged women. This study aimed at determination of ILM and IFM association with BMD in young men and women...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29568185/thermogenic-blend-alone-or-in-combination-with-whey-protein-supplement-stimulates-fat-metabolism-and-improves-body-composition-in-mice
#11
Paula de Lima Vieira-Brock, Brent M Vaughan, David L Vollmer
Background: Certain food ingredients promote thermogenesis and fat loss. Similarly, whey protein improves body composition. Due to this potential synergistic effect, a blend of thermogenic food ingredients containing African mango, citrus fruit extract, Coleus forskohlii , dihydrocapsiate, and red pepper was tested alone and in combination with a whey protein supplement for its effects on body composition in sedentary mice during high-fat diet. Objective: The objective of this study was to evaluate the interaction of thermogenic foods on improving body composition during consumption of an unhealthy diet...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29566224/feasibility-study-of-using-pcxmc-2-0-to-estimate-patient-dose-arising-from-dexa-scans
#12
Hollie Harmer, Sally Radford, Mary Smail
Patients undergoing dual energy X-ray absorption (DEXA) scans are exposed to small doses of ionizing radiation. Few papers have been published on the effective dose and organ dose for patients undergoing such scans on newer DEXA scanners. PCXMC 2.0 was used to calculate adult patient dose arising from DEXA scans. PCXMC 2.0 calculations were compared to published data and a discrepancy was noted for organ dose. Following this, effective and organ dose were measured on an anthropomorphic phantom using TLDs as a second comparison...
March 16, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29563954/evaluating-the-fat-distribution-in-idiopathic-intracranial-hypertension-using-dual-energy-x-ray-absorptiometry-scanning
#13
Catherine Hornby, Hannah Botfield, Michael W O'Reilly, Connar Westgate, James Mitchell, Susan P Mollan, Konstantinos Manolopoulos, Jeremy Tomlinson, Alexandra Sinclair
Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients ( n = 24) had a similar fat distribution to body mass index (BMI)- and gender-matched obese controls ( n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (-4...
April 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29553036/a-novel-body-circumferences-based-estimation-of-percentage-body-fat
#14
Yair Lahav, Yoram Epstein, Ron Kedem, Haggai Schermann
Anthropometric measures of body composition are often used for rapid and cost-effective estimation of percentage body fat (%BF) in field research, serial measurements and screening. Our aim was to develop a validated estimate of %BF for the general population, based on simple body circumferences measures. The study cohort consisted of two consecutive samples of health club members, designated as 'development' (n 476, 61 % men, 39 % women) and 'validation' (n 224, 50 % men, 50 % women) groups. All subjects underwent anthropometric measurements as part of their registration to a health club...
March 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29547405/fracture-risk-and-treatment-in-chronic-kidney-disease
#15
Kelsey Connelly, David Collister, Navdeep Tangri
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is associated with the development of mineral bone disorder (MBD), osteoporosis, and fragility fractures. The purpose of this review is to provide an update on recent findings in the diagnosis and treatment of osteoporosis in patients with CKD. RECENT FINDINGS: Multiple observational studies have shown that bone mineral density measurement using DEXA is equally predictive in CKD stages 1-3, as in the general population...
May 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29546280/metabolic-inflexibility-is-an-early-marker-of-bed-rest-induced-glucose-intolerance-even-when-fat-mass-is-stable
#16
Floriane Rudwill, Donal O'Gorman, Etienne Lefai, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, Allan F Pagano, Angèle Chopard, Anthony Damiot, Claire Laurens, Leanne Hodson, Emmanuelle Canet-Soulas, Martina Heer, Petra Frings Meuthen, Judith Buehlmeier, Natalie Baecker, Laure Meiller, Guillemette Gauquelin-Koch, Stéphane Blanc, Chantal Simon, Audrey Bergouignan
Context: The effects of energy balanced bed-rest on metabolic flexibility has not been thoroughly examined. Objective: We investigated the effects of 21-days bed-rest, with and without whey protein supplementation, on metabolic flexibility while maintaining energy balance. We further hypothesized protein supplementation mitigates metabolic inflexibility by preventing muscle atrophy. Design & Setting: Randomized cross-over longitudinal study conducted at the German Aerospace Center, Cologne, Germany...
March 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29545182/a-rat-model-of-shpt-with-bone-abnormalities-in-ckd-induced-by-adenine-and-a-high-phosphorus-diet
#17
Li-Hua Ni, Ri-Ning Tang, Lin-Li Lv, Min Wu, Bin Wang, Feng Mei Wang, Hai-Feng Ni, Kai-Yun Song, Li-Ting Wang, Meng-Zuo, Qiang Chen, Bi-Cheng Liu
The study of parathyroid hyperplasia with bone disease as a critical manifestation of chronic kidney disease-mineral and bone disorders (CKD-MBDs) is challenging due to the lack of a suitable research model. Here, we established a rat model with secondary hyperparathyroidism (SHPT) and bone disease induced by adenine and a high phosphorous diet and analyzed the skeletal characteristics. We performed blood analysis, emission computed tomography (ECT), dual energy X-ray absorptiometry (DEXA), micro-computed tomography (micro-CT), bone histomorphometry, and bone mechanical tests...
March 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29510545/body-fat-measurements-in-singaporean-adults-using-four-methods
#18
Xinyan Bi, Yi Ting Loo, Christiani Jeyakumar Henry
Few studies have been conducted to measure body composition in Asian populations. In this study, we determined the percent body fat (PBF) by using dual-energy X-ray absorptiometry (DEXA), air-displacement plethysmography (ADP or BOD POD), bioelectrical impedance analysis (BIA) and skinfold (SKF) in 445 healthy Singaporean adults. We observed that the BOD POD, BIA and SKF estimates of PBF were highly correlated with that from DEXA (as a reference method) among Singaporean adults. However, they all underestimated PBF (differences of 3...
March 5, 2018: Nutrients
https://www.readbyqxmd.com/read/29499415/antibody-based-inhibition-of-circulating-dlk1-protects-from-estrogen-deficiency-induced-bone-loss-in-mice
#19
Florence Figeac, Ditte C Andersen, Casper A Nipper Nielsen, Nicholas Ditzel, Søren P Sheikh, Karsten Skjødt, Moustapha Kassem, Charlotte H Jensen, Basem M Abdallah
Soluble delta-like 1 homolog (DLK1) is a circulating protein that belongs to the Notch/Serrate/delta family, which regulates many differentiation processes including osteogenesis and adipogenesis. We have previously demonstrated an inhibitory effect of DLK1 on bone mass via stimulation of bone resorption and inhibition of bone formation. Further, serum DLK1 levels are elevated and positively correlated to bone turnover markers in estrogen (E)-deficient rodents and women. In this report, we examined whether inhibition of serum DLK1 activity using a neutralizing monoclonal antibody protects from E deficiency-associated bone loss in mice...
February 27, 2018: Bone
https://www.readbyqxmd.com/read/29496562/impaired-bone-mineral-density-in-pediatric-patients-with-chronic-graft-versus-host-disease
#20
Nataliya P Buxbaum, Cemre Robinson, Ninet Sinaii, Alexander Ling, Lauren M Curtis, Steven Z Pavletic, Kristin Baird, Maya B Lodish
Pediatric allogeneic hematopoietic stem cell transplant (AHSCT) recipients with chronic graft-versus-host disease (cGVHD) are at high risk of endocrinopathies, particularly impaired bone mineral density (BMD). However, rates of BMD impairment in pediatric AHSCT recipients with cGVHD have not been well documented. We describe 33 patients with cGVHD that were referred to the NIH for the Natural History of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease Study (NCT 0092235) and underwent formal BMD assessments via dual-energy X-ray absorptiometry (DEXA)...
February 26, 2018: Biology of Blood and Marrow Transplantation
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