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https://www.readbyqxmd.com/read/27890489/spinal-muscular-atrophy-types-i-and-ii-what-are-the-differences-in%C3%A2-body-composition-and-resting-energy-expenditure
#1
Simona Bertoli, Ramona De Amicis, Chiara Mastella, Giulia Pieri, Ester Giaquinto, Alberto Battezzati, Alessandro Leone, Giovanni Baranello
BACKGROUND & AIMS: Different neuromuscular functional domains in types I and II Spinal Muscular Atrophy (SMAI and SMAII) could lead to differences in body composition (BC) and resting energy expenditure (REE). Their identification could provide the key to defining appropriate strategies in clinical dietary management, but data comparing SMAI and SMAII in terms of BC and REE are not yet available. We measured total and regional fat (FM), lean (LBM), mineral (BMC) masses, body water (total, intra- and extra-cellular, TBW, ICW, ECW) and REE in a sample of SMAI and II children, matched for age and sex, and also adjusting for body size to compare these features of the two SMA phenotypes...
November 16, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27869754/a-comparative-pharmacokinetics-study-of-the-anti-parkinsonian-drug-pramipexole
#2
Ratih S I Putri, Effi Setiawati, Syifa A Aziswan, Fenny Ong, Raymond R Tjandrawinata, Liana W Susanto
The present study aimed to compare pharmacokinetic parameters of two pramipexole 0.25 mg formulations in order to show bioequivalence. The study was conducted in a randomized, open-label, two-period, two-sequence, and crossover design, involving 23 healthy volunteers. One of the 0.25 mg formulations of pramipexole evaluated in the study was manufactured by PT Dexa Medica, Palembang, Indonesia, the other, used as the reference, by Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany. All eligible subjects were required to fast before each drug administration period, which was separated by a one-week washout period...
November 18, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27864963/chronic-alcohol-abuse-leads-to-low-bone-mass-with-no-general-loss-of-bone-structure-or-bone-mechanical-strength
#3
Maiken Parm Ulhøi, Karoline Meldgaard, Torben Steiniche, Anders Odgaard, Annie Vesterby
: Chronic alcohol abuse (CAA) has deleterious effects on skeletal health. This study examined the impact of CAA on bone with regard to bone density, structure, and strength. Bone specimens from 42 individuals with CAA and 42 individuals without alcohol abuse were obtained at autopsy. Dual-energy X-ray absorptiometry (DEXA), compression testing, ashing, and bone histomorphometry were performed. Individuals with CAA had significantly lower bone mineral density (BMD) in the femoral neck and significantly lower bone volume demonstrated by thinner trabeculae, decreased extent of osteoid surfaces, and lower mean wall thickness of trabecular osteons compared to individuals without alcohol abuse...
November 16, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27859360/physical-function-and-mobility-in-children-with-congenital-myotonic-dystrophy
#4
Evan M Pucillo, Deanna L DiBella, Man Hung, Jerry Bounsanga, Becky Crockett, Melissa Dixon, Russell J Butterfield, Craig Campbell, Nicholas E Johnson
INTRODUCTION: Congenital Myotonic Dystrophy (CDM) occurs when symptoms of myotonic dystrophy present at birth. This study evaluated the relationship between physical function, muscle mass, and age to provide an assessment of the disease and help prepare for therapeutic trials. METHODS: CDM participants performed timed functional tests (TFTs), The first 2 minutes of the 6-minute walk test (2/6MWT), myometry, and dual-energy x-ray absorption (DEXA) scans. Healthy controls (HC) performed TFTs, 6MWT, and myometry...
November 18, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27857238/implementation-of-fracture-liaison-service-in-a-new-zealand-public-hospital-waitemata-district-health-board-experience
#5
David Kim, Denise Mackenzie, Rick Cutfield
AIM: To analyse the performance of a Fracture Liaison Service (FLS) at Waitemata District Health Board (WDHB), and to detail how systematic secondary fracture prevention can be delivered in a secondary healthcare setting in New Zealand. METHOD: Clinical details of patients supervised by the WDHB FLS during the calendar year 2014 were reviewed and analysed. Additional information including treatment compliance and re-fracture rates were sought a year after initial intervention...
November 18, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27855776/periprosthetic-bone-density-changes-after-minihip-tm-cementless-femoral-short-stem-one-year-results-of-dual-energy-x-ray-absorptiometry-study
#6
Ahmet Ercan, Sherif M Sokkar, Gebhard Schmid, Timm J Filler, Ashraf Abdelkafy, Joerg Jerosch
INTRODUCTION: The purpose of the current study was to investigate the reaction of the femur to the implantation of the MiniHip(TM) in terms of: (1) bone density change during one year; (2) correlations between stem length, CCD (caput-collum-diaphyseal), femoral offset, T-value, and bone density; (3) other co-variables that influence the change of bone density. PATIENTS AND METHODS: MiniHip(TM) implant was performed for 62 patients. The age range of the patients who underwent treatment was 25-78 years...
2016: SICOT-J
https://www.readbyqxmd.com/read/27855341/the-relationship-of-fasting-hyperglycemia-to-changes-in-fat-and-muscle-mass-after-exercise-training-in-type-2-diabetes
#7
Swaytha V Yalamanchi, Kerry J Stewart, Nan Ji, Sherita H Golden, Adrian Dobs, Diane M Becker, Dhananjay Vaidya, Brian G Kral, Rita R Kalyani
AIMS: Exercise training (ET) has been variably associated with body composition changes among persons with type 2 diabetes (T2DM). The degree to which these changes are related to hyperglycemia remains unclear. Our objective was to investigate the relationship of baseline fasting glucose (FG) to the magnitude of muscle gains and fat loss after ET in individuals with T2DM. METHODS: Participants were enrolled in the SHAPE-2 trial, a six month supervised aerobic and resistance training intervention (three days/week), at Johns Hopkins...
October 10, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27836309/changes-in-taste-and-smell-function-dietary-intake-food-preference-and-body-composition-in-testicular-cancer-patients-treated-with-cisplatin-based-chemotherapy
#8
Irene IJpma, Remco J Renken, Jourik A Gietema, Riemer H J A Slart, Manon G J Mensink, Joop D Lefrandt, Gert J Ter Horst, Anna K L Reyners
BACKGROUND & AIMS: Taste and smell changes due to chemotherapy may contribute to the high prevalence of overweight in testicular cancer patients (TCPs). This study investigates the taste and smell function, dietary intake, food preference, and body composition in TCPs before, during, and up to 1 year after cisplatin-based chemotherapy. METHODS: Twenty-one consecutive TCPs participated. At baseline TCPs were compared to healthy controls (N = 48). Taste strips and 'Sniffin' Sticks' were used to determine psychophysical taste and smell function...
October 27, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27834956/a-bak-dependent-mitochondrial-amplification-step-contributes-to-smac-mimetic-glucocorticoid-induced-necroptosis
#9
Katharina Rohde, Lara Kleinesudeik, Stefanie Roesler, Oliver Löwe, Juliana Heidler, Katrin Schröder, Ilka Wittig, Stefan Dröse, Simone Fulda
Necroptosis is a form of programmed cell death that critically depends on RIP3 and MLKL. However, the contribution of mitochondria to necroptosis is still poorly understood. In the present study, we discovered that mitochondrial perturbations play a critical role in Smac mimetic/Dexamethasone (Dexa)-induced necroptosis independently of death receptor ligands. We demonstrate that the Smac mimetic BV6 and Dexa cooperate to trigger necroptotic cell death in acute lymphoblastic leukemia (ALL) cells that are deficient in caspase activation due to absent caspase-8 expression or pharmacological inhibition by the caspase inhibitor zVAD...
November 11, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27816483/sarcopenia-and-endothelial-function-in-patients-with-chronic-heart-failure-results-from-the-studies-investigating-comorbidities-aggravating-hf-sica-hf
#10
Marcelo R Dos Santos, Masakazu Saitoh, Nicole Ebner, Miroslava Valentova, Masaaki Konishi, Junichi Ishida, Amir Emami, Jochen Springer, Anja Sandek, Wolfram Doehner, Stefan D Anker, Stephan von Haehling
OBJECTIVES: Skeletal muscle wasting, also known as sarcopenia, has recently been identified as a serious comorbidity in patients with heart failure (HF). We aimed to assess the impact of sarcopenia on endothelial dysfunction in patients with HF with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). DESIGN: Cross-sectional study. SETTING: Ambulatory patients with HF were recruited at Charité Medical School, Campus Virchow-Klinikum, Berlin, Germany...
November 2, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27810029/distal-fibula-fracture-fixation-biomechanical-evaluation-of-three-different-fixation-implants
#11
Ashleen R Knutsen, Sophia N Sangiorgio, Chang Liu, Steve Zhou, Tibor Warganich, John Fleming, Thomas G Harris, Edward Ebramzadeh
BACKGROUND: The goal of this study was to evaluate the biomechanical performance of three distal fibula fracture fixation implants in a matched pair cadaveric fibula model: (1) a 5-hole compression plate with lag screw, (2) a 5-hole locking plate with lag screw, and (3) the 6-hole tabbed-plate with locking screws. METHODS: Three-dimensional motions between the proximal and distal fibular segments were measured under cyclic valgus bending, cyclic compressive axial loading, and cyclic torsional external-rotation loading...
December 2016: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27803626/body-fat-and-physical-activity-modulate-the-association-between-sarcopenia-and-osteoporosis-in-elderly-korean-women
#12
Inhwan Lee, Jinkyung Cho, Youngyun Jin, Changduk Ha, Taehee Kim, Hyunsik Kang
This study examined whether modifiable lifestyle factors, such as body fatness and physical activity, modulate the association between sarcopenia and osteoporosis. In a cross-sectional design, 269 postmenopausal women, aged 65 years and older, underwent dual-energy X-ray absorptiometry (DEXA) scans to measure their body fat percentage, total fat mass, total fat-free mass, appendicular lean mass, bone mineral density (BMD) and bone mineral content. The participants wore a uniaxial accelerometer for seven consecutive days to quantify daily physical activity...
September 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27802889/is-central-skeleton-bone-quality-a-predictor-of-the-severity-of-proximal-humeral-fractures
#13
Seung Yeol Lee, Soon-Sun Kwon, Tae Hoon Kim, Sang-Jin Shin
INTRODUCTION: The objectives of this study were to evaluate the correlation between bone attenuation around the shoulder joint assessed on conventional computed tomography (CT) and bone mineral density (BMD) based on dual-energy X-ray absorptiometry (DEXA) of the central skeleton and the correlation between the bone quality around the shoulder joint and the severity of the fracture pattern of the proximal humerus. MATERIALS AND METHODS: A total of 200 patients with proximal humeral fracture who underwent preoperative 3-dimensional shoulder CT as well as DEXA within 3 months of the CT examination were included...
October 27, 2016: Injury
https://www.readbyqxmd.com/read/27802255/diagnosing-the-undiagnosed-osteoporosis-in-patients-undergoing-lumbar-fusion
#14
Scott C Wagner, Peter M Formby, Melvin D Helgeson, Daniel G Kang
STUDY DESIGN: Retrospective analysis. OBJECTIVE: The aim of the study was to report the incidence of undiagnosed osteoporosis in patients undergoing lumbar spine fusion using computed tomography (CT) Hounsfield units (HU). SUMMARY OF BACKGROUND DATA: We used a recent technique utilizing HU to estimate bone mineral density (BMD) of the lumbar spine and hypothesized that this technique would reveal a high percentage of undiagnosed osteoporotic patients undergoing transforaminal lumbar interbody fusion (TLIF)...
November 1, 2016: Spine
https://www.readbyqxmd.com/read/27792212/postoperative-analgesia-for-elective-total-knee-arthroplasty-under-subarachnoid-anesthesia-with-opioids-comparison-between-epidural-femoral-block-and-adductor-canal-block-techniques-with-and-without-perineural-adjuvants-a-prospective-randomized-clinical-trial
#15
José R Ortiz-Gómez, Marta Perepérez-Candel, José M Vázquez-Torres, José M Rodriguez-Del Río, Berta Torrón-Abad, Inocencia Fornet-Ruiz, Francisco J Palacio-Abizanda
BACKGROUND: Optimal control of acute postoperative pain and prevention of chronic persistent pain in total knee arthroplasty (TKA) remain a challenge. The main hypothesis was that nerve blocks improve postoperative analgesia especially if perineural adjuvants are added. METHODS: Immediate postoperative pain (24 h) was evaluated every hour in 639 patients using a verbal rating 11-point scale for patient self-reporting of pain (VRS-11). All patients received subarachnoid anesthesia and were randomly allocated in 8 groups: control group, epidural (EA) and single shots femoral (FNB) or adductor canal blocks (ACB), both with and without adjuvants: dexamethasone (+Dexa) or dexmedetomidine (+Dexm)...
October 28, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27788168/dexa-body-composition-assessment-in-10-11-year-healthy-children
#16
W M Verduin, R Van Den Helder, H J Doodeman, E Struijf, A P J Houdijk
INTRODUCTION: Obesity is a growing health problem associated with metabolic derangements and cardiovascular disease. Accumulating evidence links the accumulation of visceral adipose tissue (VAT) to these obesity related health risks in adults. Childhood obesity is associated with a lifetime risk of cardiovascular disease and poses a serious challenge to future health care. In children, there is much less data on the prevalence and gender differences of visceral obesity than in adults...
2016: PloS One
https://www.readbyqxmd.com/read/27785744/bone-mineral-density-in-children-with-acute-leukemia-and-its-associated-factors-in-iran-a-case-control-study
#17
Mohammad Reza Bordbar, Sezaneh Haghpanah, Mohammad Hossein Dabbaghmanesh, Gholamhossein Ranjbar Omrani, Forough Saki
: Acute leukemia is the most common malignancy in children. We showed that low bone mass is prevalent among children with leukemia, especially in femur. Serum calcium, exercise, chemotherapy protocol, and radiotherapy are the main contributing factors. We suggest that early diagnosis and treatment of this problem could improve bone health in them. INTRODUCTION: Acute leukemia is the most common malignancy in children and has been reported to be associated with low bone mass...
December 2016: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27778231/identification-of-potential-predictive-markers-of-dexamethasone-resistance-in-childhood-acute-lymphoblastic-leukemia
#18
Nasrin Dehghan-Nayeri, Mostafa Rezaei-Tavirani, Mir Davood Omrani, Ahmad Gharehbaghian, Kourosh Goudarzi Pour, Peyman Eshghi
Response to dexamethasone (DEXA), as a hallmark drug in the treatment of childhood acute lymphoblastic leukemia (ALL), is one of the pivotal prognostic factors in the prediction of outcome in ALL. Identification of predictive markers of chemoresistance is beneficial to selecting of the best therapeutic protocol with the lowest effect adverse. Hence, we aimed to find drug targets using the 2DE/MS proteomics study of a DEXA-resistant cell line (REH) as a model for poor DEXA responding patients before and after drug treatment...
October 24, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27766504/curcumin-inhibits-paraquat-induced-lung-inflammation-and-fibrosis-by-extracellular-matrix-modifications-in-mouse-model
#19
Namitosh Tyagi, D Dash, Rashmi Singh
OBJECTIVE: Paraquat (PQ), a potent herbicide can cause severe toxicity. We report here that fibroproliferation phase of acute lung injury (ALI) is initiated much earlier (within 48 h) after PQ intoxication than previously reported (after 2 weeks) and we aimed to study the protective effects of intranasal curcumin as new therapeutic strategy in mouse model. METHODS: Mice (Park's strain) were divided into five experimental groups (I) control, received only saline (0...
October 20, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27759973/influencia-del-suplemento-con-inulina-enriquecida-con-fructooligosac%C3%A3-ridos-sobre-el-contenido-y-la-densidad-mineral-%C3%A3-sea-tras-el-parto-y-la-lactaci%C3%A3-n-en-ratas
#20
Pilar Bueno Vargas, Manuel Manzano Martín, Inmaculada López-Aliaga, José M ª López Pedrosa
Introducción: la gestación y lactancia están relacionadas con pérdidas temporales en la densidad mineral ósea (DMO) materna. Una suplementación con calcio podría resultar beneficiosa para evitar la pérdida de masa ósea del esqueleto materno. Otros nutrientes como los prebióticos han sido identificados como responsables de un incremento en la absorción de minerales, pudiendo condicionar la mineralización ósea.Objetivo: estudiar el efecto de la suplementación de la dieta materna con el prebiótico inulina enriquecida con oligofructosa, durante la gestación y la lactancia sobre el contenido mineral óseo (CMO) y la DMO al final del periodo de lactancia...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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