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Nasrin Dehghan-Nayeri, Mostafa Rezaei-Tavirani, Mir Davood Omrani, Ahmad Gharehbaghian, Kourosh Goudarzi Pour, Peyman Eshghi
Response to dexamethasone (DEXA), as a hallmark drug in the treatment of childhood acute lymphoblastic leukemia (ALL), is one of the pivotal prognostic factors in the prediction of outcome in ALL. Identification of predictive markers of chemoresistance is beneficial to selecting of the best therapeutic protocol with the lowest effect adverse. Hence, we aimed to find drug targets using the 2DE/MS proteomics study of a DEXA-resistant cell line (REH) as a model for poor DEXA responding patients before and after drug treatment...
October 24, 2016: Journal of Cell Communication and Signaling
Namitosh Tyagi, D Dash, Rashmi Singh
OBJECTIVE: Paraquat (PQ), a potent herbicide can cause severe toxicity. We report here that fibroproliferation phase of acute lung injury (ALI) is initiated much earlier (within 48 h) after PQ intoxication than previously reported (after 2 weeks) and we aimed to study the protective effects of intranasal curcumin as new therapeutic strategy in mouse model. METHODS: Mice (Park's strain) were divided into five experimental groups (I) control, received only saline (0...
October 20, 2016: Inflammopharmacology
Pilar Bueno Vargas, Manuel Manzano Martín, Inmaculada López-Aliaga, José M ª López Pedrosa
Introducción: la gestación y lactancia están relacionadas con pérdidas temporales en la densidad mineral ósea (DMO) materna. Una suplementación con calcio podría resultar beneficiosa para evitar la pérdida de masa ósea del esqueleto materno. Otros nutrientes como los prebióticos han sido identificados como responsables de un incremento en la absorción de minerales, pudiendo condicionar la mineralización ósea.Objetivo: estudiar el efecto de la suplementación de la dieta materna con el prebiótico inulina enriquecida con oligofructosa, durante la gestación y la lactancia sobre el contenido mineral óseo (CMO) y la DMO al final del periodo de lactancia...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Zulfa Abrahams, Naomi Levitt, Maia Lesosky, Gary Maartens, Joel Dave
Long-term use of antiretroviral therapy (ART) increases the risk of developing lipodystrophy. Few studies from Africa have used longitudinal data to assess the development of lipoatrophy and lipohypertrophy. We use clinical anthropometry and dual-energy X-ray absorptiometry (DEXA) to describe changes in body fat distribution over a 24-month period in individuals initiated on ART. A convenience sample of black South Africans (55 men and 132 women) were recruited and followed for 24 months after commencing ART...
October 2016: AIDS Patient Care and STDs
Francesca De Blasio, Erica P A Rutten, Emiel F M Wouters, Luca Scalfi, Francesco De Blasio, Marco A Akkermans, Martijn A Spruit, Frits M E Franssen
BACKGROUND: Visceral adipose tissue (VAT) was shown to be increased in patients with chronic obstructive pulmonary disease (COPD) compared to control subjects with comparable body mass index (BMI). Our aim was to determine the relation of VAT by dual-energy x-ray absorptiometry (DEXA) in patients with COPD by disease severity, BMI, other indices of body composition and static lung volumes. METHODS: 294 COPD patients admitted for rehabilitation were studied. Lung function, static lung volumes and body composition (i...
2016: Multidisciplinary Respiratory Medicine
Cristina Emilia Chițu-Tișu, Ecaterina Constanța Barbu, Mihai Lazăr, Mihai Bojincă, Ana-Maria Tudor, Adriana Hristea, Adrian Octavian Abagiu, Daniela Adriana Ion, Anca Ioana Bădărău
BACKGROUND: The development of combination antiretroviral therapies (cART) represents a significant advance in the treatment of (human immunodeficiency virus) HIV infection. However, several studies report that a large percentage of individuals with HIV, particularly those receiving cART, present body composition differences compared with the general population. The aim of this study was to explore body composition differences by dual-energy X-ray absorptiometry (DEXA), among HIV-positive patients receiving cART, in comparison to healthy controls...
October 11, 2016: Acta Clinica Belgica
Tarek Abdel Shafy, Adel Sayed, Ahmed H Abdelazeem
PURPOSE: Study the bone mineral density (BMD) changes and the remodelling process after implantation of a neck preserving short stem implant over a period of two years. METHODS: Using specific patients' selection criterion, a prospective study was done including 26 patients. All were operated upon by a single surgeon using the MiniHipTM, (Corin, Cirencester, UK). Mean age was 42.5 years. Clinical and radiological evaluation was done. Periprosthetic bone density was measured by DEXA...
2016: SICOT-J
William P Hedges, Marwan Bukhari
OBJECTIVE: Low body mass index (BMI) is a known risk factor for osteoporosis and is part of the FRAX™ 10-year fracture risk stratification tool for predicting fragility fractures. Little is known regarding the effects of changing body composition on bone mineral density (BMD). However, increasing fat mass (FM) improves BMD in young women with anorexia nervosa. This study aimed to assess whether changes in FM over time affected BMD in the general population. MATERIAL AND METHODS: Data was collected from patients who underwent dual-energy X-ray absorptiometry (DEXA) assessment between 2004 and 2011...
March 2016: Eur J Rheumatol
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Tae-Woo Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
Background. Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here we describe a standardized blend composed of extracts from three medicinal plants: Morus alba, Yerba mate, and Magnolia officinalis for appetite suppression and metabolic disorders management. Method. Extracts were standardized to yield a composition designated as UP601...
2016: Journal of Obesity
Wagner Luis Ripka, Jhomyr Dias Modesto, Leandra Ulbricht, Pedro Miguel Gewehr
OBJECTIVE: To analyze bone mineral density (BMD) values in adolescents and to assess obesity impact, measured through body fat #x2013;on this variable through the assessment by DEXA. METHODOLOGY: A total of 318 males adolescents (12-17 years) were evaluated considering weight, height, body mass index (BMI), bone mineral density (BMD), fat and lean mass. BMD was assessed for the arms, legs, hips, and lumbar regions, as well as for total amount. Stratification of the nutritional status was determined by body fat (%BF) percentage; comparison of groups was scrutinized by analysis of variance; and the association of variables was performed using Pearson's test...
2016: PloS One
Maude Dulac, Guy El Hajj Boutros, Charlotte Pion, Sébastien Barbat-Artigas, Gilles Gouspillou, Mylène Aubertin-Leheudre
Objective: To investigate whether handgrip strength normalized to body weight could be a useful clinical tool to identify dynapenia and assess functional capacity in post-menopausal women. Method: A total of 136 postmenopausal women were recruited. Body composition (Dual Energy X-ray Absorptiometry [DEXA], Bio-electrical Impedence Analysis [BIA]), grip strength (dynamometer) and functional capacity (senior fitness tests) were evaluated. Dynapenia was established according to a handgrip strength index (handgrip strength divided by body weight (BW) in Kg/KgBW) obtained from a reference population of young women: Type I dynapenic (<0...
September 15, 2016: Brazilian Journal of Physical Therapy
Sotirios Christodoulou, Georgios I Drosos, Athanasios Ververidis, Antonios Galanos, George Anastassopoulos, Konstantinos Kazakos
AIM: To evaluate the power of six osteoporosis-screening instruments in women in a Mediterranean country. METHODS: Data concerning several osteoporosis risk factors were prospectively collected from 1000 postmenopausal women aged 42-87 years who underwent dual-energy X-ray absorptiometry (DEXA) screening. Six osteoporosis risk factor screening tools were applied to this sample to evaluate their performance and choose the most appropriate tool for the study population...
September 18, 2016: World Journal of Orthopedics
Paik Seong Lim, Chang Hsu Chen, Fansan Zhu, Peter Kotanko, Yachung Jeng, Chun Yu Hu, Li Shu Chiu, Hui-Chen Chang
OBJECTIVE: Obesity is becoming increasingly common in hemodialysis (HD) patients and is associated with inflammation and increased mortality. The primary aim of the present study was to evaluate the accuracy and variability of the bioimpedance device in measuring body fat in Taiwanese dialysis patients. DESIGN: Cross-sectional study. SUBJECTS: One hundred twenty-two adult patients receiving HD in a single hospital in Taiwan. SETTING: We compared the results of fat mass (FM) measured by dual-energy x-ray absorptiometry (DEXA) and bioelectrical impedance spectroscopy device (Body composition monitor, BCM)...
September 22, 2016: Journal of Renal Nutrition
Süheyla Doğan Bulut, Serdar Bulut, Dicle Görkem Atalan, Rıza Gökçer Tulaci, Türker Türker, Eda Gürçay, Çiğdem Aydemir
BACKGROUND: The aim of this study was to compare the bone mineral density (BMD) of male schizophrenia patients with those of healthy controls in order to determine the relationship between BMD and hormonal changes. SUBJECTS AND METHODS: The study sample included male outpatients between 18 and 55 years old, diagnosed with schizophrenia who had used prolactin-raising antipsychotics (n=23) and prolactin-sparing antipsychotics (n=19) for at least twelve months, along with an age - matched healthy control group...
September 2016: Psychiatria Danubina
Nikos Seferos, Loukas Petrokokkinos, Antonia Kotsiou, George Rallis, Christine Tesseromatis
: Stress, via corticosteroids release, influences bone mass density. Hypericum perforatum (Hp) a traditional remedy possess antidepressive activity (serotonin reuptake inhibitor) and wound healing properties. Hp preparation contains mainly hypericin, hyperforin, hyperoside and flavonoids exerting oestrogen-mimetic effect. Cold swimming represents an experimental model of stress associating mental strain and corporal exhaustion. OBJECTIVES: This study investigates the Hp effect on femur and mandible bone mass changes in rats under cold forced swimming procedure...
2016: Stomatologija
Laura G Goetz, Ramanaiah Mamillapalli, Hugh S Taylor
The gynecological disease endometriosis is characterized by the deposition and proliferation of the endometrial cells outside the uterus and is linked to low body mass index (BMI) clinically. Gene expression in the liver of these women has not been reported. We hypothesized that endometriosis may impact hepatic gene expression to promote a low BMI. To determine the effect of endometriosis on liver gene expression, we induced endometriosis in female mice by suturing donor mouse endometrium into the peritoneal cavity and measuring the weights of these mice...
September 14, 2016: Biology of Reproduction
Basilio Moreno, Ana B Crujeiras, Diego Bellido, Ignacio Sajoux, Felipe F Casanueva
The long-term effect of therapeutic diets in obesity treatment is a challenge at present. The current study aimed to evaluate the long-term effect of a very low-calorie-ketogenic (VLCK) diet on excess adiposity. Especial focus was set on visceral fat mass, and the impact on the individual burden of disease. A group of obese patients (n = 45) were randomly allocated in two groups: either the very low-calorie-ketogenic diet group (n = 22), or a standard low-calorie diet group; (n = 23). Both groups received external support...
September 13, 2016: Endocrine
C Greenwood, J Clement, A Dicken, J P O Evans, I Lyburn, R M Martin, K Rogers, N Stone, P Zioupos
Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) using dual energy X-ray absorption (DEXA). However, the risk of osteoporotic fracture is determined collectively by bone mass, architecture and physicochemistry of the mineral composite building blocks. Thus DEXA scans alone inevitably fail to fully discriminate individuals who will suffer a fragility fracture...
September 10, 2016: Bone
James Furness, Wayne Hing, Jeremy M Sheppard, Sean Newcomer, Ben Schram, Mike Climstein
Surfing consists of both high and low intensity paddling of varying durations, utilizing both the aerobic and anaerobic systems. Surf specific physiological studies lack adequate group sample sizes and VO2peak values are yet to determine differences between competitive and recreational surfers. The purpose of this study was therefore to provide a comprehensive physiological profile of both recreational and competitive surfers. This multi-site study involved 62 male surfers, recreational (n = 47) and competitive (n = 15)...
August 31, 2016: Journal of Strength and Conditioning Research
O A Adewole, S O Giwa, O A Komolafe, M O Kayode, M O Shoga, A Adedokun
Objective: No normative database for bone mineral density (BMD) exists in Nigeria. This study aims to provide the basis for the creation of a normative reference BMD database for women in Nigeria while assessing the appropriateness of applying normative data for African American women to Nigerian females. Methods: Bone mineral density measurements of 70 women aged 50 years and above as well as 58 women aged between 23 and 30 years were taken using an accuDexa Dual X-ray Absorptiometry (DEXA) machine...
February 15, 2016: West Indian Medical Journal
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