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https://www.readbyqxmd.com/read/28446578/brain-negativity-as-an-indicator-of-predictive-error-processing-the-contribution-of-visual-action-effect-monitoring
#1
Michael Joch, Mathias Hegele, Heiko Maurer, Hermann Müller, Lisa Katharina Maurer
The error-(related)-negativity (Ne/ERN) is an event-related potential in the electroencephalogram (EEG) correlating with error processing. Its conditions of appearance prior to terminal external error information suggest that the Ne/ERN is indicative of predictive processes in the evaluation of errors. The aim of the present study was to specifically examine the Ne/ERN in a complex motor task and to particularly rule out other explaining sources of the Ne/ERN aside from error prediction processes. To this end, we focused on the dependency of the Ne/ERN on visual monitoring about the action outcome after movement termination but prior to result feedback (action effect monitoring)...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28445079/multiple-antimicrobial-resistance-and-novel-point-mutation-in-fluoroquinolone-resistant-escherichia-coli-isolates-from-mangalore-india
#2
Santhosh Kogaluru Shivakumaraswamy, Deekshit Vijaya Kumar, Venugopal Moleyuru Nagarajappa, Iddya Karunasagar, Indrani Karunasagar
Fluoroquinolone resistance in bacteria is usually associated with mutations in the topoisomerase regions. We report a novel point mutation in fluoroquinolone-resistant Escherichia coli strains. E. coli isolated from the environment in and around Mangalore, India, were examined for their antimicrobial resistance profile to 12 antibiotics and for the antibiotic resistance genes by polymerase chain reaction. Of the 67 E. coli isolated, 24 (35.8%) were sensitive to all antibiotics and 43 (64.2%) showed resistance to at least one of the 12 antibiotics used in the study...
April 26, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28435335/what-is-the-effect-of-a-shoulder-strengthening-program-to-prevent-shoulder-pain-among-junior-female-team-handball-players
#3
Maria Sommervold, Håvard Østerås
BACKGROUND: Excessively high stresses are applied to the shoulder joint of handball players, mainly caused by overhead throwing. Shoulder pain is a significant problem among junior female team handball players and both male and female top-level team handball players in Norway. METHOD: A randomized selection was performed among the best female junior teams (J 16) in the Trøndelag region of Norway in the 2014-2015 season. Three teams were randomized to the intervention group and three teams to the control group...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/28429751/preclinical-study-of-raav2-strail-pharmaceutical-efficacy-biodistribution-and-safety-in-animals
#4
Q Ru, W Li, X Wang, S Zhang, L Chen, Y Zhang, Y Ge, Y Zu, Y Liu, D Zheng
The recombinant sTRAIL has been in clinical trial for various human malignancies. However, the half-life time of sTRAIL is very short, which might be an important factor influencing its clinical efficacy for cancer therapy. We previously reported the recombinant adeno-associated virus (AAV)-encoding sTRAIL95-281-mediated sTRAIL expression in vivo up to 8 months and suppressed tumor growth markedly in mouse xenografts. In the present study, we further evaluated the clinical potency for cancer gene therapy and the safety in mouse and non-human primates...
April 21, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28427795/reappraisal-to-the-study-of-4e-bp1-as-an-mtor-substrate-a-normative-critique
#5
REVIEW
Asiya Batool, Sabreena Aashaq, Khurshid Iqbal Andrabi
mTOR-4E-BP1 axis is regarded as the best oncogenic circuitry impinging on translational control whereby mTORC1 dictates post-translational regulation of 4E-BP1. This review provides new insights into the molecular network of signalling pathways highlighting the recent explosion of studies in respect to the deviant behaviour of 4E-BP1 towards mTORC1. Despite the striking conservation of mTOR nexus, the eccentric phosphorylation dynamics of 4E-BP1 negate the apparent linear architecture of mTORC1 attesting the importance of other kinases that may evoke cross-talks with the conventional frame, most of which are enlisted in the manuscript...
April 8, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28426949/agarra-agarran-evidence-of-early-comprehension-of-subject-verb-agreement-in-spanish
#6
Nayeli Gonzalez-Gomez, Lisa Hsin, Isabelle Barrière, Thierry Nazzi, Géraldine Legendre
Studies across many languages (e.g., Dutch, English, Farsi, Spanish, Xhosa) have failed to show early acquisition of subject-verb (SV) agreement, whereas recent studies on French reveal acquisition by 30months of age. Using a similar procedure as in previous French studies, the current study evaluated whether earlier comprehension of SV agreement in (Mexican) Spanish can be revealed when task demands are lowered. Two experiments using a touch-screen pointing task tested comprehension of SV agreement by monolingual Spanish-speaking children growing up in Mexico City between about 3 and 5years of age...
April 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28426378/ostracism-and-physiological-arousal-following-traumatic-brain-injury
#7
Michelle Kelly, Skye McDonald, Jacqueline Rushby
PRIMARY OBJECTIVE: This study aimed to examine the psychological and physiological effects of ostracism in adults with traumatic brain injury (TBI). RESEARCH DESIGN: A within-subject, counterbalanced design was used. The two conditions, inclusion and ostracism, were examined across two groups (between subjects). METHODS AND PROCEDURES: A group of 21 adults with TBI and 17 matched controls participated in the Cyberball paradigm. This task is a computerised task that exposes participants to a game of catch and throw...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28424849/ultrasound-evaluation-of-the-ulnar-collateral-ligament-of-the-elbow-which-method-is-most-reproducible
#8
Mehool Shukla, Robert Keller, Nathan Marshall, Hafeez Ahmed, Courtney Scher, Vasilios Bill Moutzouros, Marnix van Holsbeeck
INTRODUCTION: The ulnar collateral ligament (UCL) is an important medial stabilizer of the elbow, particularly in overhead-throwing athletes. However, there is no universally accepted method for evaluating UCL thickness with ultrasound (US). OBJECTIVE: To assess reproducibility of previously published methods, as well as a modified technique, for evaluating the UCL via US. We hypothesize that a modified technique would show greater reproducibility. MATERIAL AND METHODS: Using US, the thickness of the UCL in 50 volunteers was measured by two musculoskeletal trained radiologists using two different measurement techniques...
April 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28416852/-first-aid-system-for-trauma-development-and-status
#9
D K Chen, W C Lin, P Zhang, S J Kuang, W Huang, T B Wang
With the great progress of the economy, the level of industrialization has been increasing year by year, which leads to an increase in accidental trauma accidents. Chinese annual death of trauma is already more than 400 000, which makes trauma the fifth most common cause of death, following malignant tumor, heart, brain and respiratory diseases. Trauma is the leading cause of the death of young adults. At the same time, trauma has become a serious social problem in peace time. Trauma throws great treats on human health and life...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28413242/agriculture-in-africa-telling-myths-from-facts-a-synthesis
#10
EDITORIAL
Luc Christiaensen
Stylized facts drive research agendas and policy debates. Yet robust stylized facts are hard to come by, and when available, often outdated. The 12 papers in this Special Issue revisit conventional wisdom on African agriculture and its farmers' livelihoods using nationally representative surveys from the Living Standards Measurement Study-Integrated Surveys on Agriculture Initiative in six African countries. At times they simply confirm our common understanding of the topic. But they also throw up a number of surprises, redirecting policy debates while fine-tuning others...
February 2017: Food Policy
https://www.readbyqxmd.com/read/28412692/review-research-on-the-physical-training-model-of-human-body-based-on-hq
#11
Liu Junjie
Health quotient (HQ) is the newest health culture and concept in the 21st century, and the analysis of the human body sports model is not enough mature at present, what's more, the purpose of this paper is to study the integration of the two subjects the health quotient and the sport model. This paper draws the conclusion that physical training and education in colleges and universities can improve the health quotient, and it will make students possess a more healthy body and mind. Then through a new rigid body model of sports to simulate the human physical exercise...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28412351/effect-of-apoa4-on-serpina3-mediated-by-nuclear-receptors-nr4a1-and-nr1d1-in-hepatocytes
#12
Yupeng Zhang, Jing He, Jing Zhao, Min Xu, Danwen Lou, Patrick Tso, Zongfang Li, Xiaoming Li
ApoA4 exerts anti-inflammatory effects, but the mechanism remains unclear. SERPINA3 is a member of the serine proteinase inhibitor gene family, and has been shown to be involved in anti-inflammation and associated with a number of human diseases. In this study, we revealed that ApoA4 stimulates the gene expression of SERPINA3 in mouse hepatocytes both in vivo and in vitro, in a dose- and time-dependent manner. The transcriptional response of SERPINA3 to ApoA4 is regulated through the binding of ApoA4 with nuclear receptors NR4A1 and NR1D1 on the SERPINA3 promoter, which was verified with ChIP, Luciferase activity assay and RNA interference-mediated NR4A1 or NR1D1 gene knockdown...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28410998/a-retrospective-longitudinal-analysis-of-anthropometric-and-physical-qualities-that-associate-with-adult-career-attainment-in-junior-rugby-league-players
#13
Kevin Till, David Morley, John O'Hara, Ben L Jones, Chris Chapman, Clive B Beggs, Carlton Cooke, Stephen Cobley
OBJECTIVES: To retrospectively compare the longitudinal physical development of junior rugby league players between the Under 13 and 15 age categories in relation to their adult career attainment outcome. DESIGN: Retrospective longitudinal design. METHODS: Fifty-one former junior rugby league players were retrospectively grouped according to their career attainment outcome as adults (i.e., amateur, academy or professional). As juniors, players undertook a physical testing battery on three consecutive annual occasions (Under 13s, 14s, 15s) including height, body mass, sum of four skinfolds, maturation, vertical jump, medicine ball chest throw, 10-60m sprint, agility 505 and estimated V˙O2max ...
March 30, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28410775/don-t-throw-smokeless-tobacco-users-under-the-bus
#14
Jesse Elias, Yogi Hendlin, Benjamin W Chaffee, Pamela M Ling
No abstract text is available yet for this article.
April 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28410542/estimation-of-critical-supersaturation-solubility-ratio-for-predicting-diameters-of-dry-particles-prepared-by-air-jet-atomization-of-solutions
#15
Mahak Sapra, Suraj Ugrani, Y S Mayya, Chandra Venkataraman
Air-jet atomization of solution into droplets followed by controlled drying is increasingly being used for producing nanoparticles for drug delivery applications. Nanoparticle size is an important parameter that influences the stability, bioavailability and efficacy of the drug. In air-jet atomization technique, dry particle diameters are generally predicted by using solute diffusion models involving the key concept of critical supersaturation solubility ratio (Sc) that dictates the point of crust formation within the droplet...
April 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28410050/the-deterministic-information-bottleneck
#16
D J Strouse, David J Schwab
Lossy compression and clustering fundamentally involve a decision about which features are relevant and which are not. The information bottleneck method (IB) by Tishby, Pereira, and Bialek (1999) formalized this notion as an information-theoretic optimization problem and proposed an optimal trade-off between throwing away as many bits as possible and selectively keeping those that are most important. In the IB, compression is measured by mutual information. Here, we introduce an alternative formulation that replaces mutual information with entropy which, we call the deterministic information bottleneck (DIB) and we argue, better captures this notion of compression...
April 14, 2017: Neural Computation
https://www.readbyqxmd.com/read/28409511/multimodal-assessment-of-sensorimotor-shoulder-function-in-patients-with-untreated-anterior-shoulder-instability-and-asymptomatic-handball-players
#17
Guillaume Mornieux, Anja Hirschmüller, Albert Gollhofer, Norbert P Südkamp, Dirk Maier
BACKGROUND: Functional evaluation of sensorimotor function of the shoulder joint is important for guidance of sports-specific training, prevention and rehabilitation of shoulder instability. Such assessment should be multimodal and comprise all qualities of sensorimotor shoulder function. This study evaluates feasibility of such multimodal assessment of glenohumeral sensorimotor function in patients with shoulder instability and handball players. METHODS: Nine patients with untreated anterior instability of their dominant shoulder and 15 asymptomatic recreational handball players performed proprioceptive joint position sense and dynamic stabilisation evaluations on an isokinetic device, as well as a functional throwing performance task...
April 13, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28401776/molecular-characteristics-of-the-envelope-of-vertically-transmitted-hiv-1-strains-from-infants-with-hiv-infection
#18
Manickam Ashokkumar, Manohar Nesakumar, Cheedarla Narayanaiah, Vidya Vijayan Kk, Babu Hemalatha, Srikanth P Tripathy, Luke Elizabeth Hanna
Mother-to-child transmission of HIV offers a good opportunity to study the dynamics of early viral evolution in the host environment to which the virus has partially adapted. Such studies would throw light on the unique features of the infecting viruses, which will subsequently help to design preventive or therapeutic measures against the newly infecting and evolving strains of HIV. Therefore, we undertook a study to determine the genetic divergence of proviral envelope sequences from the HIV infected infants (< 2 years)...
April 12, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28398820/magnetic-resonance-imaging-predictors-of-failure-in-the-nonoperative-management-of-ulnar-collateral-ligament-injuries-in-professional-baseball-pitchers
#19
Salvatore J Frangiamore, T Sean Lynch, Michael D Vaughn, Lonnie Soloff, Michael Forney, Joseph F Styron, Mark S Schickendantz
BACKGROUND: A medial ulnar collateral ligament (UCL) injury of the elbow is an increasingly common injury in professional baseball pitchers. Predictors of success and failure are not well defined for the nonoperative management of these injuries. PURPOSE: To evaluate the efficacy of objective measures to predict failure of the nonoperative management of UCL injuries. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Thirty-two professional pitchers (82%) met inclusion criteria and underwent an initial trial of nonoperative treatment for UCL tears based on clinical and radiological findings...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28396902/progressive-skeletal-benefits-of-physical-activity-when-young-as-assessed-at-the-midshaft-humerus-in-male-baseball-players
#20
S J Warden, A M Weatherholt, A S Gudeman, D C Mitchell, W R Thompson, R K Fuchs
Physical activity benefits the skeleton, but there is contrasting evidence regarding whether benefits differ at different stages of growth. The current study demonstrates that physical activity should be encouraged at the earliest age possible and be continued into early adulthood to gain most skeletal benefits. INTRODUCTION: The current study explored physical activity-induced bone adaptation at different stages of somatic maturity by comparing side-to-side differences in midshaft humerus properties between male throwing athletes and controls...
April 10, 2017: Osteoporosis International
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