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https://www.readbyqxmd.com/read/28527383/tributyltin-and-triphenyltin-exposure-promotes-in-vitro-adipogenic-differentiation-but-alters-the-adipocyte-phenotype-in-rainbow-trout
#1
Esmail Lutfi, Natàlia Riera-Heredia, Marlon Córdoba, Cinta Porte, Joaquim Gutiérrez, Encarnación Capilla, Isabel Navarro
Numerous environmental pollutants have been identified as potential obesogenic compounds affecting endocrine signaling and lipid homeostasis. Among them, well-known organotins such as tributyltin (TBT) and triphenyltin (TPT), can be found in significant concentrations in aquatic environments. The aim of the present study was to investigate in vitro the effects of TBT and TPT on the development and lipid metabolism of rainbow trout (Onchorynchus mykiss) primary cultured adipocytes. Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα) protein expression when compared to a control, both in the presence or absence of lipid mixture...
May 8, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28527321/short-term-exposure-to-gold-nanoparticle-suspension-impairs-swimming-behavior-in-a-widespread-calanoid-copepod
#2
François-Gaël Michalec, Markus Holzner, Alexandre Barras, Anne-Sophie Lacoste, Loïc Brunet, Jae-Seong Lee, Christian Slomianny, Rabah Boukherroub, Sami Souissi
Calanoid copepods play an important role in the functioning of marine and brackish ecosystems. Information is scarce on the behavioral toxicity of engineered nanoparticles to these abundant planktonic organisms. We assessed the effects of short-term exposure to nonfunctionalized gold nanoparticles on the swimming behavior of the widespread estuarine copepod Eurytemora affinis. By means of three-dimensional particle tracking velocimetry, we reconstructed the trajectories of males, ovigerous and non-ovigerous females...
May 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28527212/apolipoprotein-e4-gender-body-mass-index-inflammation-insulin-resistance-and-air-pollution-interactions-recipe-for-alzheimer-s-disease-development-in-mexico-city-young-females
#3
Lilian Calderón-Garcidueñas, Suzanne M de la Monte
Given the epidemiological trends of increasing Alzheimer's disease (AD) and growing evidence that exposure and lifestyle factors contribute to AD risk and pathogenesis, attention should be paid to variables such as air pollution, in order to reduce rates of cognitive decline and dementia. Exposure to fine particulate matter (PM2.5) and ozone (O3) above the US EPA standards is associated with AD risk. Mexico City children experienced pre- and postnatal high exposures to PM2.5, O3, combustion-derived iron-rich nanoparticles, metals, polycyclic aromatic hydrocarbons, and endotoxins...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527102/studies-of-environmental-risk-factors-in-amyotrophic-lateral-sclerosis-als-and-a-phase-i-clinical-trial-of-l-serine
#4
Walter G Bradley, R X Miller, T D Levine, E W Stommel, P A Cox
β-N-Methylamino-L-alanine (BMAA) has been linked to Guam ALS/PDC and shown to produce neurodegeneration in vitro and in vivo (Drosophila, mice, rats, primates). BMAA misincorporation into neuroproteins produces protein misfolding and is inhibited by L-serine. Case-control studies in Northern New England indicate that living near to water-bodies with cyanobacterial blooms increases the risk of developing amyotrophic lateral sclerosis (ALS). The distribution of addresses of ALS cases in New Hampshire, Vermont, and Florida was compared to that of controls...
May 19, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28526659/framework-for-assessing-causality-of-air-pollution-related-health-effects-for-reviews-of-the-national-ambient-air-quality-standards
#5
Elizabeth Oesterling Owens, Molini M Patel, Ellen Kirrane, Thomas C Long, James Brown, Ila Cote, Mary A Ross, Steven J Dutton
To inform regulatory decisions on the risk due to exposure to ambient air pollution, consistent and transparent communication of the scientific evidence is essential. The United States Environmental Protection Agency (U.S. EPA) develops the Integrated Science Assessment (ISA), which contains evaluations of the policy-relevant science on the effects of criteria air pollutants and conveys critical science judgments to inform decisions on the National Ambient Air Quality Standards. This article discusses the approach and causal framework used in the ISAs to evaluate and integrate various lines of scientific evidence and draw conclusions about the causal nature of air pollution-induced health effects...
May 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28526320/mercury-exposure-induces-cytoskeleton-disruption-and-loss-of-renal-function-through-epigenetic-modulation-of-mmp9-expression
#6
Hafizurrahman Khan, Radha Dutt Singh, Ratnakar Tiwari, Siddhartha Gangopadhyay, Somendu Kumar Roy, Dhirendra Singh, Vikas Srivastava
Mercury is one of the major heavy metal pollutants occurring in elemental, inorganic and organic forms. Due to ban on most inorganic mercury containing products, human exposure to mercury generally occurs as methylmercury (MeHg) by consumption of contaminated fish and other sea food. Animal and epidemiological studies indicate that MeHg affects neural and renal function. Our study is focused on nephrotoxic potential of MeHg. In this study, we have shown for the first time how MeHg could epigenetically modulate matrix metalloproteinase 9(MMP9) to promote nephrotoxicity using an animal model of sub chronic MeHg exposure...
May 16, 2017: Toxicology
https://www.readbyqxmd.com/read/28526200/nickel-and-ocean-warming-affect-scleractinian-coral-growth
#7
T Biscéré, A Lorrain, R Rodolfo-Metalpa, A Gilbert, A Wright, C Devissi, C Peignon, R Farman, E Duvieilbourg, C Payri, F Houlbrèque
The sensitivity of corals and their Symbiodinium to warming has been extensively documented; however very few studies considered that anthropogenic inputs such as metal pollution have already an impact on many fringing reefs. Thus, today, nickel releases are common in coastal ecosystems. In this study, two major reef-building species Acropora muricata and Pocillopora damicornis were exposed in situ to ambient and moderate nickel concentrations on a short-term period (1h) using benthic chamber experiments. Simultaneously, we tested in laboratory conditions the combined effects of a chronic exposure (8weeks) to moderate nickel concentrations and ocean warming on A...
May 17, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28525860/a-comparison-of-individual-exposure-perception-and-acceptable-levels-of-pm2-5-with-air-pollution-policy-objectives-in-china
#8
Lei Huang, Chao Rao, Tsering Jan van der Kuijp, Jun Bi, Yang Liu
Atmospheric pollution has emerged as a major public health issue in China. Public perception and acceptable risk levels of air pollution can prompt individual behavioral changes and play a major role in the public's response to health risks. Therefore, to explore these responses and evaluate what constitutes publicly acceptable concentrations of fine particulate matter (PM2.5), questionnaire surveys were conducted in three representative cities of China: Beijing, Nanjing, and Guangzhou. Great differences in public risk perception were revealed...
May 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28525859/the-association-between-ambient-inhalable-particulate-matter-and-the-disease-burden-of-respiratory-disease-an-ecological-study-based-on-ten-year-time-series-data-in-tianjin-china
#9
Qiang Zeng, Ziting Wu, Guohong Jiang, Xiaoyin Wu, Pei Li, Yang Ni, Xiuqin Xiong, Xinyan Wang, Parasat, Guoxing Li, Xiaochuan Pan
There is limited evidence available worldwide about the quantitative relationship between particulate matter with an aerodynamic diameter of less than 10µm (PM10) and years of life lost (YLL) caused by respiratory diseases (RD), especially regarding long-term time series data. We investigated the quantitative exposure-response association between PM10 and the disease burden of RD. We obtained the daily concentration of ambient pollutants (PM10, nitrogen dioxide and sulphur dioxide), temperature and relative humidity data, as well as the death monitoring data from 2001 to 2010 in Tianjin...
May 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28525857/industrial-air-emissions-and-proximity-to-major-industrial-emitters-are-associated-with-anti-citrullinated-protein-antibodies
#10
Sasha Bernatsky, Audrey Smargiassi, Lawrence Joseph, Phillip Awadalla, Ines Colmegna, Marie Hudson, Marvin J Fritzler
OBJECTIVE: To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2). METHODS: The CARTaGENE first-wave cohort includes 20,000 general population subjects from Quebec (Canada). On a sample of unselected 1586 subjects, we determined serum, ACPA and performed multivariable logistic regression, for the outcome of positive ACPA, assessing for independent effects of our air pollution variables, adjusting for age, sex, smoking, and French Canadian origin...
May 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28525815/an-integrated-approach-to-study-the-risk-from-landfill-soil-of-delhi-chemical-analyses-in-vitro-assays-and-human-risk-assessment
#11
Swati, Pooja Ghosh, Indu Shekhar Thakur
In the present study, landfill soil of three municipal solid waste landfill sites of Delhi, India were toxico-chemically analyzed for human risk assessment as inadequate information is available on the possible health effects of the contaminants present in landfill soil. The landfill soil samples were prepared for analyzing heavy metal concentration, organic contaminants and toxicity analysis separately. Composite soil sample collected from three landfill sites were analyzed for heavy metal by ICP-AES. Metal concentration so obtained was below the permissible limit of soil but higher than the set limits for effluent...
May 16, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28525650/detection-of-damage-on-single-or-double-stranded-dna-in-a-population-exposed-to-arsenic-in-drinking-water
#12
J Jiménez-Villarreal, D I Rivas-Armendariz, C P Pineda-Belmontes, N D Betancourt-Martínez, M A Macías-Corral, A J Guerra-Alanis, M S Niño-Castañeda, J Morán-Martínez
Different studies have suggested an association between arsenic (As) exposure and damage to single-stranded DNA by reactive oxygen species derived from the biotransformation of arsenic. The single strand damages are converted to double strand damage upon interaction with ultraviolet radiation. Analysis of genomic integrity is important for assessing the genotoxicity caused by environmental pollutants. In this study, we compared the concentration of As in drinking water, nutritional status, lifestyle variables, and the level of genotoxicity in an exposed population and a control group...
May 18, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28525627/geographic-patterns-of-autism-spectrum-disorder-among-children-of-nurses-health-study-ii-women
#13
Kate Hoffman, Marc G Weisskopf, Andrea L Roberts, Raanan Raz, Jaime E Hart, Kristen Lyall, Elin M Hoffman, Francine Laden, Verónica M Vieira
Data indicate that autism spectrum disorder (ASD) prevalence may be increasing and varies geographically. We investigated associations between residential location and ASD in the children of Nurses' Health Study II women in order to generate hypotheses about social and environmental factors related to etiology or diagnosis. Analyses included 13,507 children born from 1989-1999 (486 with ASD). We explored relationships between ASD and residential location at both birth and age 6 years (i.e. closer to average diagnosis age)...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28525551/who-among-the-elderly-is-most-vulnerable-to-exposure-and-health-risks-of-pm2-5-from-wildfire-smoke
#14
Jia Coco Liu, Ander Wilson, Loretta J Mickley, Keita Ebisu, Melissa P Sulprizio, Yun Wang, Roger D Peng, Xu Yue, Francesca Dominici, Michelle L Bell
Wildfires burn over 7 million US acres annually, according to the US Forest Service. Little is known regarding which subpopulations are more vulnerable to health risks from wildfire smoke, including fine particles. We estimated exposure to fine particles specifically from wildfires and associations between wildfire-specific fine particles and respiratory hospital admissions for subpopulations > 65 years in the Western US (2004-2009). Higher fractions of Blacks and people in urban counties and in California are exposed to > 1 smoke wave (high-pollution episodes from wildfire smoke) compared to other populations...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28524743/nanoparticle-exposures-from-nano-enabled-toner-based-printing-equipment-and-human-health-state-of-science-and-future-research-needs
#15
Sandra Vanessa Pirela, John Martin, Dhimiter Bello, Philip Demokritou
Toner formulations used by laser printers (LP) and photocopiers (PC), collectively called "toner-based printing equipment" (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE...
May 19, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28523621/ecotoxicological-assessment-of-the-impact-of-fluoride-f-and-turbidity-on-the-freshwater-snail-physella-acuta-in-a-polluted-river-receiving-an-industrial-effluent
#16
Julio A Camargo, Álvaro Alonso
We carried out field studies and laboratory experiments to assess the impact of fluoride (F(-)) and turbidity on the freshwater snail Physella acuta in a polluted river receiving an industrial effluent (the middle Duraton River, Central Spain). Fluoride concentrations and turbidity levels significantly increased downstream from the industrial effluent (with the highest values being 0.6 mg F(-)/L and 55.2 nephelometric turbidity unit). In addition, higher deposition of fine inorganic matter was evident at polluted sampling sites...
May 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28522830/inhibition-of-endocytic-lipid-antigen-presentation-by-common-lipophilic-environmental-pollutants
#17
Manju Sharma, Xiang Zhang, Shuangmin Zhang, Liang Niu, Shuk-Mei Ho, Aimin Chen, Shouxiong Huang
Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants. To test this notion, we determined whether the common lipophilic pollutants benzo[a]pyrene and diesel exhaust particles impact on the activation of lipid-specific T cells. Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521815/proportion-of-cancer-in-a-middle-eastern-country-attributable-to-established-risk-factors
#18
Maya A Charafeddine, Sara H Olson, Deborah Mukherji, Sally N Temraz, Ghassan K Abou-Alfa, Ali I Shamseddine
BACKGROUND: Providing an estimate of the percentage of cancer in Lebanon by 2018 that is due to the exposure to risk factors in 2008. Factors include: smoking, body mass index (BMI), physical inactivity, dietary factors, alcohol consumption, infections, and air pollution in adults. METHOD: Population Attributable Fraction (PAF) was calculated using the proportion of the population exposed and relative risks for each risk factor from meta-analyses. The PAF estimates the proportion of cases in which exposure may have played a causal role...
May 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28521238/transcriptomic-approach-for-assessment-of-the-impact-on-microalga-and-macrophyte-of-in-situ-exposure-in-river-sites-contaminated-by-chlor-alkali-plant-effluents
#19
Perrine Dranguet, Claudia Cosio, Séverine Le Faucheur, Rebecca Beauvais-Flück, Aline Freiburghaus, Isabelle A M Worms, Brice Petit, Natacha Civic, Mylène Docquier, Vera I Slaveykova
Water quality degradation is a worldwide problem, but risk evaluation of chronic pollution in-situ is still a challenge. The present study aimed to evaluate the potential of transcriptomic analyses in representative aquatic primary producers to assess the impact of environmental pollution in-situ: the microalga Chlamydomonas reinhardtii and the macrophyte Elodea nuttallii were exposed 2 h in the Babeni Reservoir of the Olt River impacted by chlor-alkali plant effluent release resulting in increased concentrations of Hg and NaCl in receiving water...
May 11, 2017: Water Research
https://www.readbyqxmd.com/read/28521192/long-term-exposure-to-residential-ambient-fine-and-coarse-particulate-matter-and-incident-hypertension-in-post-menopausal-women
#20
Trenton Honda, Melissa N Eliot, Charles B Eaton, Eric Whitsel, James D Stewart, Lina Mu, Helen Suh, Adam Szpiro, Joel D Kaufman, Sverre Vedal, Gregory A Wellenius
BACKGROUND: Long-term exposure to ambient particulate matter (PM) has been previously linked with higher risk of cardiovascular events. This association may be mediated, at least partly, by increasing the risk of incident hypertension, a key determinant of cardiovascular risk. However, whether long-term exposure to PM is associated with incident hypertension remains unclear. METHODS: Using national geostatistical models incorporating geographic covariates and spatial smoothing, we estimated annual average concentrations of residential fine (PM2...
May 15, 2017: Environment International
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