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Pregnancy and psychotropics

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https://www.readbyqxmd.com/read/27883308/response-to-ethical-and-clinical-dilemmas-in-using-psychotropic-medications-during-pregnancy
#1
Jennifer Piel, Suzanne B Murray, Carmen Antonela Croicu
No abstract text is available yet for this article.
November 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27738382/maternal-and-fetal-outcomes-after-lamotrigine-use-in-pregnancy-a-retrospective-analysis-from-an-urban-maternal-mental-health-centre-in-new-zealand
#2
Chandni Prakash, Susan Hatters-Friedman, Charmian Moller-Olsen, Abigail North
INTRODUCTION: Pregnancy is a vulnerable period for recurrence of bipolar disorder. Discontinuation of mood stabilisers during pregnancy and the postpartum period can significantly increase the risk of recurrence of bipolar disorder. Lamotrigine is an anti-epileptic drug that has been approved for the maintenance treatment of bipolar disorder. Epilepsy literature has indicated that lamotrigine has a reassuring safety profile in pregnancy but there is little information on its effectiveness and safety in pregnant women with mental disorders...
August 15, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/27704220/a-review-of-the-safety-of-clozapine-during-pregnancy-and-lactation
#3
Taylor M Mehta, Ryan J Van Lieshout
Clozapine is an antipsychotic used in the management of treatment-resistant schizophrenia. However, little is known about clozapine use during pregnancy and lactation, or its impact on the mother, foetus, and infant. This review aims to summarize the available literature on the safety of clozapine use during the perinatal period. EMBASE, PsycINFO, and MEDLINE were searched from their inceptions through June 2016. The review encompasses 21 studies that have examined clozapine use during pregnancy and lactation...
October 4, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27624748/women-s-questions-about-medicines-in-pregnancy-an-analysis-of-calls-to-an-australian-national-medicines-call-centre
#4
Eva L Pijpers, Sanne Kreijkamp-Kaspers, Treasure M McGuire, Laura Deckx, Wendy Brodribb, Mieke L van Driel
BACKGROUND: For many medicines, safe use during pregnancy is not established and adherence is often poor due to safety concerns. Therefore, it is important to identify consumers' medicines information needs during pregnancy. MATERIALS AND METHODS: A retrospective, mixed methods analysis was conducted on eight years of pregnancy-related calls to an Australian national medicines call centre. The call profile of pregnancy and non-pregnancy-related questions were compared...
September 14, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27573673/-psychopharmacotherapy-during-pregnancy-which-antipsychotics-tranquilizers-and-hypnotics-are-suitable
#5
N Bergemann, W E Paulus
BACKGROUND: When administering psychotropic drugs during pregnancy not only the potential teratogenic effects on the child must be addressed but also the fetotoxic implications for pregnancy and/or the peripartum phase as well as possible neurocognitive developmental disorders must be considered. OBJECTIVE: Evaluation of the risks and benefits of administering psychotropic drugs during pregnancy or for women who wish to become pregnant. METHODS: The literature has been reviewed with the purpose of providing information on psychotropic drugs which can safely be administered during pregnancy...
September 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27573672/-affective-disorders-during-pregnancy-therapy-with-antidepressants-and-mood-stabilizers
#6
N Bergemann, W E Paulus
BACKGROUND: It is not rare that the first manifestation or relapse of an affective disorder occurs during pregnancy. Should a pharmacological treatment be indicated, the selection of a suitable substance should be made on a basis which is as safe as possible. Even when treating women of childbearing age it should be assured that the psychotropic drug selected is safe to use during pregnancy as a high percentage of pregnancies are unplanned. OBJECTIVE: When assessing the risks and benefits of psychopharmacotherapy in women who are or wish to get pregnant, not only the exposure of the child to potentially teratogenic drug effects but also potential complications during or after pregnancy and long-term neuropsychological issues need to be addressed...
September 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27467032/-pharmacokinetic-and-pharmacodynamic-effects-of-psychotropic-medications-differences-between-sexes
#7
J D Bergiannaki, P Kostaras
The gender based or gender sensitive pharmacology is a new research area. Differences among sexes are observed in several parameters of their pharmacokinetic which may relate to alteration of their pharmacodynamic as well. Most psychotropics are given per os, and the greater part of their absorption takes place in the small intestine. Premenopausal women have slower gastric emptying times and lower gastrointestinal blood flow which probably reduces the extent of drug absorption. The distribution of drugs is influenced by the relative lower body mass index, the lower blood volume and flow and the greater percentage of body fat of women...
April 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27444984/drug-interactions-between-hormonal-contraceptives-and-psychotropic-drugs-a-systematic-review
#8
Erin N Berry-Bibee, Myong-Jin Kim, Katharine B Simmons, Naomi K Tepper, Halley E M Riley, H Pamela Pagano, Kathryn M Curtis
OBJECTIVE: To examine whether the co-administration of hormonal contraceptives (HC) and psychotropic drugs commonly used to treat anxiety and/or depression results in safety or efficacy concerns for either drug. METHODS: We searched PubMed and Cochrane libraries for clinical or pharmacokinetic (PK) studies that examined co-administration of any HC with psychotropic drugs [selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), oral benzodiazepines, bupropion, mirtazapine, trazadone, buspirone, hydroxyzine, monoamine oxidase inhibitors (MAOIs), or atypical antipsychotics] in reproductive aged women...
July 18, 2016: Contraception
https://www.readbyqxmd.com/read/27324073/psychomotor-developmental-effects-of-prenatal-exposure-to-psychotropic-drugs-a-study-in-efemeris-database
#9
Caroline Hurault-Delarue, Christine Damase-Michel, Laurent Finotto, Claudine Guitard, Christophe Vayssière, Jean-Louis Montastruc, François Montastruc, Isabelle Lacroix
Little is known about neurodevelopment of children exposed to psychotropic drugs during pregnancy. The purpose of this study was to evaluate the effects of prenatal exposure to psychotropic drugs on psychomotor development in children. This observational study used the EFEMERIS database. The database records the drugs prescribed and delivered during pregnancy and the resulting outcomes. Neurodevelopment at nine and 24 months of children born to women exposed to psychotropic drugs (anxiolytics, antidepressants, neuroleptics and anti-epileptics) during the second and/or third trimesters of pregnancy was compared to children who were not exposed to these drugs...
October 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27322995/ethical-and-clinical-dilemmas-in-using-psychotropic-medications-during-pregnancy
#10
Andrea L Kalfoglou
Approximately 15 percent of women experience depression while pregnant or in the year following pregnancy. While antidepressants are usually effective and considered standard treatment for depression, concerns arise that what might be good for mom could be harmful for the baby. Medical evidence demonstrates that, on balance, treating mental illness with psychotropic medication along with talk therapy is in the best interest of both mother and baby; however, women may resist treatment because they overestimate the risks of medication and underestimate the risks of untreated mental illness...
2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27289228/neonatal-adaptation-issues-after-maternal-exposure-to-prescription-drugs-withdrawal-syndromes-and-residual-pharmacological-effects
#11
REVIEW
Irma Convertino, Alice Capogrosso Sansone, Alessandra Marino, Maria T Galiulo, Stefania Mantarro, Luca Antonioli, Matteo Fornai, Corrado Blandizzi, Marco Tuccori
Exposure to drugs during pregnancy has the potential to harm offspring. Teratogenic effects are the most feared adverse outcomes in newborns; however, a wide spectrum of less known, usually reversible and often acute, neonatal adverse events can also occur due to drug intake by mothers during pregnancy, particularly in close proximity to delivery. This narrative review is aimed at the description of drugs and drug classes for which licit maternal use in the predelivery period has been associated with neonatal non-teratogenic disorders...
October 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27143891/patterns-of-psychotropic-medication-use-in-inpatient-and-outpatient-psychiatric-settings-in-saudi-arabia
#12
Fahad D Alosaimi, Abdulhadi Alhabbad, Mohammed F Abalhassan, Ebtihaj O Fallata, Nasser M Alzain, Mohammad Zayed Alassiry, Bander Abdullah Haddad
OBJECTIVE: To study the pattern of psychotropic medication use and compare this pattern between inpatient and outpatient psychiatric settings in Saudi Arabia. METHOD: This cross-sectional observational study was conducted between July 2012 and June 2014 on patients seeking psychiatric advice at major hospitals in five main regions of Saudi Arabia. Male (n=651) and female (n=594) patients who signed the informed consent form and were currently or had been previously using psychotropic medications, irrespective of the patient's type of psychiatric diagnosis and duration of the disease, were included...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27137419/wishful-thinking-is-not-effective-contraception-family-planning-contraception-and-safe-prescribing
#13
Marlene P Freeman
Unplanned pregnancies account for approximately 50% of pregnancies in the United States and 40% globally. Therefore, it is good clinical practice to treat women of reproductive potential with the idea in mind that they may become pregnant during the course of treatment, regardless of their stated intentions. In psychiatry, most of the disorders we treat are chronic or recurrent; women are often on psychotropic medications during the reproductive years, and many will require pharmacologic treatment for psychiatric illnesses during pregnancy...
April 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27131586/depression-anxiety-and-psychotropic-medication-use-and-fecundability
#14
Yael I Nillni, Amelia K Wesselink, Jaimie L Gradus, Elizabeth E Hatch, Kenneth J Rothman, Ellen M Mikkelsen, Lauren A Wise
BACKGROUND: The literature regarding the associations between depression, anxiety, and fecundity is inconsistent. While cross-sectional studies suggest that depression and/or anxiety may adversely affect fecundity, the sole cohort study showed only a small association. OBJECTIVE: We sought to evaluate the association of self-reported depressive symptoms, self-reported diagnoses of depression and anxiety, and psychotropic medication use with fecundability in a prospective cohort study...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27085086/atropinic-burden-of-drugs-during-pregnancy-and-psychological-development-of-children-a-cohort-study-in-the-efemeris-database
#15
Anna-Belle Beau, Jean-Louis Montastruc, Isabelle Lacroix, François Montastruc, Caroline Hurault-Delarue, Christine Damase-Michel
AIM: The aim of this study was to evaluate the potential effect of in utero exposure to drugs with atropinic properties on infant psychological development using atropinic burden (AB) scales. METHODS: Women from the EFEMERIS cohort, a French database including prescribed and dispensed reimbursed drugs during pregnancy and pregnancy outcomes, delivering between 2004 and 2010 were included (n = 43 740). Each drug was classified as having no (score = 0), few (score = 1) or strong (score = 3) atropinic properties...
August 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27029490/risks-and-benefits-of-psychotropic-medication-in-pregnancy-cohort-studies-based-on-uk-electronic-primary-care-health-records
#16
Irene Petersen, Rachel L McCrea, Cormac J Sammon, David P J Osborn, Stephen J Evans, Phillip J Cowen, Nick Freemantle, Irwin Nazareth
BACKGROUND: Although many women treated with psychotropic medication become pregnant, no psychotropic medication has been licensed for use in pregnancy. This leaves women and their health-care professionals in a treatment dilemma, as they need to balance the health of the woman with that of the unborn child. The aim of this project was to investigate the risks and benefits of psychotropic medication in women treated for psychosis who become pregnant. OBJECTIVE(S): (1) To provide a descriptive account of psychotropic medication prescribed before pregnancy, during pregnancy and up to 15 months after delivery in UK primary care from 1995 to 2012; (2) to identify risk factors predictive of discontinuation and restarting of lithium (multiple manufacturers), anticonvulsant mood stabilisers and antipsychotic medication; (3) to examine the extent to which pregnancy is a determinant for discontinuation of psychotropic medication; (4) to examine prevalence of records suggestive of adverse mental health, deterioration or relapse 18 months before and during pregnancy, and up to 15 months after delivery; and (5) to estimate absolute and relative risks of adverse maternal and child outcomes of psychotropic treatment in pregnancy...
March 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27027463/a-liquid-chromatography-tandem-mass-spectrometry-method-for-quantifying-amisulpride-in-human-plasma-and-breast-milk-applied-to-measuring-drug-transfer-to-a-fully-breast-fed-neonate
#17
Sean J OʼHalloran, Antonia Wong, David A Joyce
BACKGROUND: Amisulpride is a second generation atypical antipsychotic drug. The management of psychosis exacerbation in late pregnancy or during lactation is often hampered by inadequate knowledge of risk to the baby from placental transfer or breast milk transfer of drugs. There is no specific information on adverse effects from amisulpride. To gather guiding information from one mother-baby pair, we conducted a drug concentration study on the fourth post-natal day and developed a novel liquid chromatography-tandem mass spectrometry method with application to the very small plasma volumes obtainable from a neonate, requiring 15 μL of plasma, and with application to human breast milk...
August 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27021348/bisphenol-a-phthalates-and-lead-and-learning-and-behavioral-problems-in-canadian-children-6-11-years-of-age-chms-2007-2009
#18
Tye E Arbuckle, Karelyn Davis, Khrista Boylan, Mandy Fisher, Jingshan Fu
Childhood developmental disorders and related problems such as learning disabilities and attention deficit hyperactivity disorder (ADHD) account for a growing burden on the family, education and health care systems. Exposure to environmental chemicals such as bisphenol A (BPA) and phthalates may play a role in the development of child behavioral problems. Using cross-sectional data from Cycle 1 of the Canadian Health Measures Survey (CHMS), we examined the potential association between urinary concentrations of BPA and various phthalate metabolites and child learning and behavioral problems, considering important covariates such as gender, blood lead and environmental tobacco smoke (ETS)...
May 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27018245/how-to-take-into-account-exposure-to-drugs-over-time-in-pharmacoepidemiology-studies-of-pregnant-women
#19
Caroline Hurault-Delarue, Cécile Chouquet, Nicolas Savy, Isabelle Lacroix, Anna-Belle Beau, Jean-Louis Montastruc, Christine Damase-Michel
PURPOSE: The aim of this study was to develop a new pharmacoepidemiological method to take into account intensity and evolution of drug exposure, applied to pregnant women. METHODS: Pregnant women were classified according to their drug exposure, in three steps: Conversion of prescription data into exposure variables (using ATC-DDD) Construction of individual trajectories of exposure Clustering of individual trajectories of exposure (using the R package Kml) We applied this method to psychotropic drugs prescribed during pregnancy...
July 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/26930533/preschool-outcomes-following-prenatal-serotonin-reuptake-inhibitor-exposure-differences-in-language-and-behavior-but-not-cognitive-function
#20
Katrina C Johnson, Alicia K Smith, Zachary N Stowe, D Jeffrey Newport, Patricia A Brennan
OBJECTIVE: To test the hypothesis that prenatal exposure to serotonin reuptake inhibitors (SRIs) is associated with language and behavioral outcomes in preschool-aged children, while accounting for confounds such as concomitant exposures and maternal mental illness. METHOD: An observational, prospective, longitudinal study of mental illness in pregnancy was conducted at a university-based women's mental health clinic (April 2010-November 2012). A sample of 178 mother-child dyads participated in a laboratory visit at preschool age (2...
February 2016: Journal of Clinical Psychiatry
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