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Onychomycosis

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https://www.readbyqxmd.com/read/28639462/onychomycosis-in-the-21st-century-an-update-on-diagnosis-epidemiology-and-treatment
#1
Aditya K Gupta, Sarah G Versteeg, Neil H Shear
Onychomycosis accounts for 50% of all nail disease cases and is commonly caused by dermatophytes. Diabetes, human immunodeficiency virus, immunosuppression, obesity, smoking, and advancing age are predisposing factors of this fungal infection. Potassium hydroxide and culture are considered the current standard for diagnosing onychomycosis, revealing both fungal viability and species identification. Other diagnostic tests currently available include periodic acid-Schiff staining, polymerase chain reaction techniques, and fluorescent staining...
June 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28622558/photodynamic-therapy-treatment-of-onychomycosis-with-aluminium-phthalocyanine-chloride-nanoemulsions-a-proof-of-concept-clinical-trial
#2
Luciano Ferreira Morgado, Ana Regina Franchi Trávolo, Luís Alexandre Muehlmann, Paulo Souza Narcizo, Rodrigo Barbosa Nunes, Pedro Alencar Gomes Pereira, Karen Rapp Py-Daniel, Cheng-Shi Jiang, Jinsong Gu, Ricardo Bentes Azevedo, João Paulo Figueiró Longo
The conventional treatment of onychomycosis, a common fungal infection, consists in the use of local and systemic drugs for 4-6 months. This long protocol is often ineffective due to patient compliance, and usually promotes important collateral effects such as liver and kidney failure. As the alternative, Photodynamic Therapy (PDT) has been used as a noninvasive alternative local treatment for onychomycosis due to the reduction of systemic side effects, fact indicates their use for patients undergoing other systemic treatments...
June 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28611995/an-update-on-the-disappearing-nail-bed
#3
Ralph Daniel, Babaev Meir, Shemer Avner
BACKGROUND: The nail bed may epithelialize and develop dermatoglyphics after long-standing onycholysis. We have called this phenomenon the disappearing nail bed (DNB). DNB may present as a shortened or narrow nail bed. METHODS: Examination of all 20 nails was performed in each patient enrolled to the study. DNB was defined as the presence of a nail which is at least 20% shorter and/or narrower than the identical nail on the opposite hand or foot. Age, sex, and nail history were recorded...
March 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28609764/hemodialysis-and-kidney-transplantation-as-predisposing-conditions-to-onychomycosis
#4
Antonio M S Filho, Carlucci G Ventura, Paulo R Criado, Gilda B Del Negro, Roseli S Freitas, Olinda C Luiz, Mauro C Giudice, Elias D Neto, Gil Benard
BACKGROUND/AIM: Onychomycosis (OM) is one of the commonest superficial fungal infections. Patients undergoing hemodialysis (HD) treatment and kidney transplant recipients (KTR) are considered at risk of contracting fungal infections, but the few published data do not reach the conclusion of whether they are predisposed to OM. This study aimed to determine the prevalence and etiology of OM in these patients and to determine the antifungal susceptibility profile of the isolated fungal species...
June 14, 2017: Nephron
https://www.readbyqxmd.com/read/28594608/etiology-of-onychomycosis-in-patients-turkey
#5
Fatma Pelin Cengiz, Bengu Cevirgen Cemil, Nazan Emiroglu, Anılgülsel Bahalı, Dilek Biyik Ozkaya, Ozlem Su, Nahide Onsun
BACKGROUND: Onychomycosis is the chronic infection of the nails, and it is caused by dermatophytes, Candida, non- dermatophyte molds, Trichosporon genus. METHODS: A retrospective analysis of 225 cases with onychomycosis, diagnosed in a 27-month period at the Department of Dermatoveneorology, Bezmialem Vakif University in Istanbul, and confirmed with culture. RESULTS: The age of patients ranged from 2 to 87 years (41.59 ± 17.61) and females were more commonly affected (120 cases, 53...
June 8, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28558997/onychomatricoma-a-rare-and-potentially-underreported-tumor-of%C3%A2-the%C3%A2-nail-matrix
#6
Calvin J Rushing, Roman Ivankiv, Neal M Bullock, Diana E Rogers, Steven M Spinner
Onychomatricoma is a rare benign neoplasm of the nail matrix first described by Baran and Kint in 1992. Fewer than 80 cases of onychomatricoma have been described in the literature, 15 of which were initially misdiagnosed and treated as onychomycosis. We present the case of a 66-year-old male with thickening and linear xanthonychia of the hallux nail plate secondary to an onychomatricoma misdiagnosed as onychomycosis. Following biopsy for histopathologic analysis, the lesion and proximal nail matrix were surgically excised...
May 27, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28557542/the-efficacy-of-fractional-carbon-dioxide-co2-laser-combined-with-terbinafine-hydrochloride-1-cream-for-the-treatment-of-onychomycosis
#7
Jian Shi, Jin Li, He Huang, Felicia Permatasari, Juan Liu, Yang Xu, Di Wu, Bing-Rong Zhou, Dan Luo
BACKGROUND: Although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects and the efficacy of topical agents is not satisfying. Currently, laser treatment has been studied for its efficacy in the treatment of onychomycosis. Our study was aimed to evaluate the efficacy of fractional carbon dioxide (CO2) laser treatment combined with terbinafine cream for 6 months in the treatment of onychomycosis and to analyze the influencing factors...
May 30, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28525623/the-survey-of-tinea-capitis-and-scalp-dermatophyte-carriage-in-nursing-home-residents
#8
Chien-Yio Lin, Hsiu-Jung Lo, Ming-Gene Tu, Yu-Ming Ju, Yun-Chen Fan, Chih-Chao Lin, Ya-Ting Chiang, Yun-Liang Yang, Kai-Ting Chen, Pei-Lun Sun
Tinea capitis is a contagious dermatophyte infection of scalp and associated hairs. On the other hand, asymptomatic carriage is a status of positive dermatophyte scalp culture, but without signs or symptoms of tinea capitis, and no evidence of hair shaft invasion confirmed by direct microscopy. Tinea capitis and asymptomatic carriage mostly occur in children, but adult females are becoming another population in recent decades. In this study, we focused on the prevalence and related fungi of tinea capitis and asymptomatic carriage in elderly by the shampoo brush method, as well as the source of transmission, in 10 nursing home residents...
May 18, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28521541/evaluation-of-the-efficacy-and-safety-of-tavaborole-topical-solution-5-in-the-treatment-of-onychomycosis-of-the-toenail-in-adults-a-pooled-analysis-of-an-8-week-post-study-follow-up-from-two-randomized-phase-3-studies
#9
Aditya K Gupta, Steve Hall, Lee T Zane, Shari R Lipner, Phoebe Rich
PURPOSE: The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis. METHODS: We conducted a pooled analysis of 8-week, post-study follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail (CN) at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compared with placebo in adults with distal subungual onychomycosis was evaluated at week 60...
May 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28508389/usefulness-of-techniques-based-on-real-time-pcr-for-the-identification-of-onychomycosis-causing-species
#10
Anissa Z Hafirassou, Clara Valero, Nadia Gassem, Ilhem Mihoubi, Maria J Buitrago
Onychomycosis (OM) is a nail infection caused mainly by dermatophyte species but other species of yeast and moulds are frequently involved as well. Classical diagnosis has limitations thus empirical treatment is common. The usefulness of different real time PCR (RT-PCR) assays for identifying species causing OM was assessed in samples from seventy patients and fifteen controls. Conventional methods and four different RT-PCR assays were used: a panfungal, a pandermatophyte and two specific assays for detecting Candida spp...
May 16, 2017: Mycoses
https://www.readbyqxmd.com/read/28504456/performance-of-mycology-and-histopathology-tests-for-the-diagnosis-of-toenail-onychomycosis-due-to-filamentous-fungi-dermatophyte-and-non-dermatophyte-moulds
#11
Fernanda G Lavorato, Dávson A Guimarães, Mario G Premazzi, Juan M Piñeiro-Maceira, Andréa R Bernardes-Engemann, Rosane Orofino-Costa
Improvement of laboratory diagnosis of onychomychosis is important so that adequate treatment can be safely implemented. To evaluate and compare the performance of mycological and histopathological examinations in onychomycoses caused by dermatophyte and non-dermatophyte moulds. Patients with lateral/distal subungual onychomycosis in at least one hallux were enrolled in the protocol and assessed via mycological and histopathological tests. The isolation of filamentous fungi was considered the gold standard...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28492600/efinaconazole-solution-10-for-treatment-of-toenail-onychomycosis-in-latino-patients
#12
Fran E Cook-Bolden, Tina Lin
Onychomycosis is a common progressive fungal infection of the nail bed, matrix, or plate leading to destruction and deformity of the toenails and fingernails. The prevalence of onychomycosis is increasing in the United States, particularly in the growing population of Latino patients. In this study, we evaluated the efficacy and safety of efinaconazole solution 10% in Latino patients with onychomycosis. Once-daily application of efinaconazole solution 10% may be an effective topical option for treatment of onychomycosis in this patient population...
April 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28477005/biosynthesis-of-zinc-oxide-nanoparticles-by-petals-extract-of-rosa-indica-l-its-formulation-as-nail-paint-and-evaluation-of-antifungal-activity-against-fungi-causing-onychomycosis
#13
Nikita Tiwari, Raksha Pandit, Swapnil Gaikwad, Aniket Gade, Mahendra Rai
Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of Rosa indica L. (rose). Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with ZnO-NPs. Methods and results: The synthesised ZnO-NPs were preliminary detected by using ultraviolet UV visible spectroscopy, which showed specific absorbance...
March 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28472375/laser-treatment-of-onychomycosis-due-to-neoscytalidium-dimidiatum-an-open-prospective-study
#14
Andreia Pizarro Leverone, Dávson Aguilar Guimarães, Andréa Reis Bernardes-Engemann, Rosane Orofino-Costa
Conventional systemic and topical treatments have proven ineffective for the treatment of onychomycosis caused by Neoscytalidium dimidiatum. Our aim was to evaluate the effectiveness and safety of laser monotherapy for the treatment of onychomycosis caused by this pathogen. Patients with clinical onychomycosis of the toenails and positive results both on direct mycological examination and N. dimidiatum culture underwent four 1064 nm Nd:YAG laser sessions with 6-week intervals between sessions. Participants were monitored by clinical examination supported by dermoscopy, measurement of diseased nail and the onychomycosis severity index (OSI), and by mycological examination for 12 months after completion of treatment...
May 2, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28451560/caspofungin-non-susceptible-candida-orthopsilosis-isolated-from-onychomycosis-in-iran
#15
Rasoul Mohammadi, Hossein Mirhendi, Mohammad Taghi Hedayati, Hamid Badali
BACKGROUND: Although Candida albicans remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans Candida species. Despite worrying clinical pictures associated with latter species, there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains having been studied. METHODS: We evaluated the in vitro antifungal susceptibilities of clinical isolates of C...
February 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28438926/evaluation-of-the-ability-of-a-novel-miconazole-formulation-to-penetrate-nail-using-three-nail-in-vitro-models
#16
Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, Marc Brown
In an effort to increase the efficacy of topical medications to treat onychomycosis, several new nail penetration enhancers have recently been developed. In this study, the ability of 10% w/w miconazole nitrate, combined with a penetration enhancer formulation to permeate the nail, is demonstrated by the use of a selection of in vitro nail penetration assays. These assays include bovine hoof, TurChub® zone of inhibition, and infected nail models.
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28436564/high-prevalence-of-superficial-white-onychomycosis-by-trichophyton-interdigitale-in-a-japanese-nursing-home-with-a%C3%A2-geriatric-hospital
#17
Seiji Watanabe, Kazushi Anzawa, Takashi Mochizuki
A mycological survey on feet was performed in a nursing home with a geriatric hospital to ascertain the prevalence of tinea lesions. Of 100 subjects, comprising 62 in the nursing home and 38 in the geriatric wing, 70 were diagnosed with tinea pedis, tinea unguium (onychomycosis) or both of which 54 had onychomycosis alone, nine tinea pedis alone and seven had co-existing onychomycosis and tinea pedis. The most common clinical type of onychomycosis was distal lateral subungual onychomycosis (DLSO) at 30 cases, followed by superficial white onychomycosis (SWO) at 23 cases...
April 24, 2017: Mycoses
https://www.readbyqxmd.com/read/28432163/an-unusually-large-onychomatricoma
#18
Pedro Beirão, Patrícia Pereira, Andreia Nunes, Hugo Barreiros
Onychomatricoma is a rare benign tumour of the nail matrix first described in 1992, and since then, no more than 80 cases have been reported. Despite distinct clinical characteristics, it is frequently misdiagnosed as onychomycosis partly due to remaining an unknown entity. The authors present the case of a patient with a 30-year history of nail abnormalities with more recent growth to alarming dimensions.
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28417140/onychomycosis-due-to-arthrinium-arundinis-a-case-report
#19
Mariusz Dyląg, Anita Hryncewicz-Gwóźdź, Tomasz Jagielski
No abstract text is available yet for this article.
April 18, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28405739/dermatological-comorbidity-in-psoriasis-results-from-a-large-scale-cohort-of-employees
#20
N Zander, I Schäfer, M Radtke, A Jacobi, H Heigel, M Augustin
The field of dermatological comorbidity in psoriasis is only passively explored with contradictory results. Objective of this study was to further investigate the complex field of psoriasis and associated skin diseases by identifying skin comorbidity patterns in an extensive cohort of employees in Germany. Retrospective analysis of data deriving from occupational skin cancer screenings was conducted. From 2001 to 2014 German employees between 16 and 70 years from different branches underwent single whole-body screenings by trained dermatologists in their companies...
April 12, 2017: Archives of Dermatological Research
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