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Onychomycosis

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https://www.readbyqxmd.com/read/28332720/efficacy-and-safety-of-luliconazole-5-nail-solution-for-the-treatment-of-onychomycosis-a-multicenter-double-blind-randomized-phase-iii-study
#1
Shinichi Watanabe, Hiroshi Kishida, Akihiro Okubo
Onychomycosis is a highly prevalent and intractable disease. The first-line treatment agents are oral preparations, but an effective topical medication has long been desired. The objective was to investigate the efficacy and safety of luliconazole 5% nail solution, an imidazole antifungal agent, for the treatment of patients with onychomycosis. A multicenter, double-blind, randomized phase III study was conducted in Japanese patients with distal lateral subungual onychomycosis affecting the great toenails, with 20-50% clinical involvement...
March 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28329600/delay-in-diagnosis-of-acral-melanoma
#2
Roberto Rheingantz da Cunha Filho, Leandra Matte, Ricardo Hohmann Camina
We report a 41-year-old woman presented with a 4-year history of an exuberant, erythematous tumor, with necrotic appearance of the right distal toe. The histopathology examination showed a nodular-ulcerative melanoma, with bone infiltration. Widespread metastases including the right ovary, peritoneum, and right breast were present. The patient was misdiagnosed for almost 4 years as having onychomycosis, ingrown nail and pyogenic granuloma.
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328287/photobiomodulation-with-non-thermal-lasers-mechanisms-of-action-and-therapeutic-uses-in-dermatology-and-aesthetic-medicine
#3
Mark Nestor, Anneke Andriessen, Brian Berman, Bruce E Katz, Dore Gilbert, David J Goldberg, Michael H Gold, Robert S Kirsner, Paul Z Lorenc
BACKGROUND: Non-thermal laser therapy in dermatology, is a growing field in medical technology by which therapeutic effects are achieved by exposing tissues to specific wavelengths of light. OBJECTIVES: The purpose of this review was to gain a better understanding of the science behind non-thermal laser and the evidence supporting its use in dermatology. METHODS: A group of dermatologists and surgeons recently convened to review the evidence supporting the use of non-thermal laser for body sculpting, improving the appearance of cellulite, and treating onychomycosis...
February 17, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28294418/a-critical-review-of-improvement-rates-for-laser-therapy-used-to-treat-toenail-onychomycosis
#4
REVIEW
A K Gupta, S G Versteeg
BACKGROUND: Onychomycosis is a nail infection that is primary caused by dermatophytes. Alternative treatments are needed as current therapies (oral and topical antifungals) have limited effectiveness. Lasers are currently approved by the FDA to temporarily increase the amount of clear nail in onychomycosis patients. Lasers can theoretically elicit fungicidal effects but in practice produce mixed results. OBJECTIVE: This review compares laser-induced improvement rates to FDA approved indications and traditional onychomycosis treatments...
March 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28289970/trans-ungual-delivery-of-ar-12-a-novel-antifungal-drug
#5
Avadhesh Singh Kushwaha, P Sharma, H N Shivakumar, C Rappleye, A Zukiwski, S Proniuk, S Narasimha Murthy
AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into and across the human nail plate followed by improving its trans-ungual permeation using different penetration enhancers. TranScreen-N™, a high throughput screening method was utilized to explore the potential nail penetration enhancers to facilitate the drug delivery through the nail...
March 13, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28271946/the-effect-of-long-pulsed-nd-yag-laser-for-the-treatment-of-onychomycosis
#6
Gökhan Okan, Nagehan Tarikci, Gonca Gokdemir
BACKGROUND: Topical onychomycosis therapies are usually inadequate, and patient compliance to systemic therapies is poor. Recently, interest in laser therapy for the treatment of onychomycosis has increased. We sought to investigate the efficacy of long-pulsed Nd:YAG laser therapy for onychomycosis. METHODS: Thirty patients with mycologically confirmed onychomycosis received long-pulsed 1064-nm Nd:YAG laser therapy, moving the beam in a spiral pattern over the whole nail plate two times, with a 1-minute pause between passes...
January 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28263845/new-polyurethane-nail-lacquers-for-the-delivery-of-terbinafine-formulation-and-antifungal-activity-evaluation
#7
Barbara S Gregorí Valdes, Ana Paula Serro, Paulo M Gordo, Alexandra Silva, Lídia Gonçalves, Ana Salgado, Joana Marto, Diogo Baltazar, Rui Galhano Dos Santos, João Moura Bordado, Helena Margarida Ribeiro
Onychomycosis is a fungal nail infection. The development of new topical antifungal agents for the treatment of onychomycosis has focused on formulation enhancements that optimize the pharmacological characteristics required for its effective treatment. Polyurethanes (PUs) have never been used in therapeutic nail lacquers. The aim of this work has been the development of new PU based nail lacquers with antifungal activity containing 1.0% (w/w) of terbinafine hydrochloride. The biocompatibility, wettability and the prediction of the free volume in the polymeric matrix were assessed using a human keratinocytes cell line, contact angle and Positron Annihilation Lifetime Spectroscopy (PALS) determinations, respectively...
March 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28256766/nail-neoplasms
#8
REVIEW
Ji-Hye Park, Dong-Youn Lee, Noori Kim
Nail neoplasms include all tumors occurring in the nail or periungual apparatus tissue. While some nail tumors can be similar to tumors located on the skin, others are unique. Both benign and malignant lesions can affect the nail apparatus. In particular, early malignant tumors like melanoma and squamous cell carcinoma can present similarly to onychomycosis or benign melanonychia and frequently missed by clinicians. Therefore, physicians should be aware of nail structures and the characteristics of nail tumors...
March 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28237676/in-vitro-antifungal-activity-of-organic-compounds-derived-from-amino-alcohols-against-onychomycosis
#9
César Augusto Caneschi, Angelina Maria de Almeida, Francislene Juliana Martins, Mireille Le Hyaric, Manoel Marques Evangelista Oliveira, Gilson Costa Macedo, Mauro Vieira de Almeida, Nádia Rezende Barbosa Raposo
Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a-4f) and p-hydroxybenzoic acid (9a-9f)...
February 9, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28233292/accelerated-nail-growth-rate-in-hiv-patients
#10
Elisa C Sánchez-Moreno, Selina Marioni-Manriquez, Ramón F Fernández-Martínez, Gabriela Moreno-Coutiño
BACKGROUND: Many factors have been noted to alter the growth rate of both finger and toe nails, some with harder evidence than others. Infectious diseases are among the ones reported as slowing the growth rate. However, on previous studies we noticed that patients living with HIV and onychomycosis could be cured without the use of antifungal therapy, only with the immunological improvement provided by the combined antiretroviral therapy, and we wanted to prove that the growth rate is also increased in this group and thus probably contributes to the cure of onychomycosis...
February 23, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28225975/descriptive-analysis-of-mycological-examination-of-patients-with-onychomycosis-treated-in-private-practice
#11
John Verrinder Veasey, Flávio Nappi, Clarisse Zaitz, Laura Hitomi Muramatu
This is a retrospective study of 160 patients treated in private practice in São Paulo from March 2003 to March 2015. We analyzed 171 results of direct mycological examinations and fungal cultures from nail scrapings. The agreement between direct mycological examination results and fungal culture was satisfactory, consistent with the literature (kappa 0.603). The main agent identified was Trichophyton rubrum (51%). We observed an isolation rate of non-dermatophyte filamentous fungi superior to the literature (34%)...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28222676/meta-analysis-of-the-utility-of-culture-biopsy-and-direct-koh-examination-for-the-diagnosis-of-onychomycosis
#12
Verónica Velasquez-Agudelo, Jaiberth Antonio Cardona-Arias
BACKGROUND: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. METHODS: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies...
February 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28217436/the-first-report-of-onychomycosis-caused-by-cryptococcus-friedmannii-naganishia-friedmannii-a-basidiomycetous-yeast
#13
Masoome Ekhtiari, Shirin Farahyar, Mehraban Falahati, Elham Razmjou, Mahtab Ashrafi-Khozani, Zeinab Ghasemi, Ziba Abbasi-Nejat
Yeasts are common etiologic agents of onychomycosis. This study reported a case of onychomycosis due to Cryptococcus friedmannii (Naganishia friedmannii). This yeast was isolated of the right great toenail of 57-year-old man. Microscopic examination of nail scrapings showed budding cells with thin capsule. Sequence analyzes of the internal transcribed spacer regions was closely related to Cryptococcus friedmannii. The results of susceptibility testing showed the Cryptococcus friedmannii to be sensitive to fluconazole, itraconazole and amphotericin B...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28210388/topical-treatment-for-onychomycosis-is-it-more-effective-than-the-clinical-data-suggests
#14
REVIEW
Boni E Elewski, Tracey C Vlahovic, Andrew Korotzer
Background: The current definition of complete cure is considered too stringent to reflect the true benefit of onychomycosis treatment seen in general practice and may limit the use of newer topical agents in mild-to-moderate disease. In addition, outcomes reported in clinical trials do not consistently report secondary endpoints, making data comparison difficult. Methods: The authors review the clinical data reported on two new topical antifungals, efinaconazole and tavaborole, in light of the latest thinking of more practical approaches to assess improvement and treatment success...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28188648/pilot-study-to-evaluate-a-plasma-device-for-the-treatment-of-onychomycosis
#15
S R Lipner, G Friedman, R K Scher
Onychomycosis is a fungal infection of the nail unit, and is the most common of the nail disorders. Current therapies for onychomycosis have less than ideal efficacy and have the potential for adverse effects. As previous studies have shown that nonthermal plasma inhibits the in vitro growth of Trichophyton rubrum, we conducted a pilot study on 19 participants with toenail onychomycosis. The primary endpoint was safety of the device, and secondary outcome measures were clinical efficacy and mycological cure...
February 11, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28188051/incidence-and-biodiversity-of-yeasts-dermatophytes-and-non-dermatophytes-in-superficial-skin-infections-in-assiut-egypt
#16
A H Moubasher, M A Abdel-Sater, Z Soliman
OBJECTIVE: The aim was to identify the incidence of the causal agents from dermatophytes, non-dermatophytes and yeasts in Assiut Governorate employing, beside the morphological and physiological techniques, the genotypic ones. PATIENTS: Samples from infected nails, skin and hair were taken from 125 patients. MATERIALS AND METHODS: Patients who presented with onychomycosis, tinea capitis, tinea corporis, tinea cruris and tinea pedis during the period from February 2012 to October 2015 were clinically examined and diagnosed by dermatologists and were guided to Assiut University Mycological Centre for direct microscopic examination, culturing and identification...
February 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28160226/molecular-diagnostic-techniques-for-onychomycosis-validity-and-potential-application
#17
Shinichi Watanabe, Kazuya Ishida
BACKGROUND: Diagnosis of onychomycosis requires positive findings by direct microscopy and fungal culture. Fungal culture is slow and difficult, with low yields. We compared two dermatophyte identification methods, one using a real-time polymerase chain reaction (PCR) method, and the other using fungal culture to validate the molecular method. METHODS: Nail specimens were collected from 149 patients with distal and lateral subungual onychomycosis who were positive for fungal elements by direct microscopy using potassium hydroxide...
April 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28134122/pseudo-onychomycosis
#18
Mitsuhito Ota
No abstract text is available yet for this article.
February 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28128500/pdt-for-onychomycosis
#19
L R Braathen
No abstract text is available yet for this article.
February 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28116600/transungual-gel-of-terbinafine-hydrochloride-for-the-management-of-onychomycosis-formulation-optimization-and-evaluation
#20
Purva Thatai, Bharti Sapra
The present study was aimed to optimize, develop, and evaluate microemulsion and microemulsion-based gel as a vehicle for transungual drug delivery of terbinafine hydrochloride for the treatment of onychomycosis. D-optimal mixture experimental design was adopted to optimize the composition of microemulsion having amount of oil (X 1), Smix (mixture of surfactant and cosurfactant; X 2), and water (X 3) as the independent variables. The formulations were assessed for permeation (micrograms per square centimeter per hour; Y 1), particle size (nanometer; Y 2), and solubility of the drug in the formulation (milligrams per milliliter; Y 3)...
January 23, 2017: AAPS PharmSciTech
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