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Onychomycosis

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https://www.readbyqxmd.com/read/29050446/management-of-mycoses-in-daily-practice
#1
Lorenzo Drago, Giuseppe Micali, Manuela Papini, Bianca M Piraccini, Stefano Veraldi
The guideline recommendations, albeit founded on thorough reviews of clinically relevant literature data, are often not immediately adaptable to everyday life. Considering the marked heterogeneity of superficial mycoses, each of them requires specific management in a real life context; in all cases diagnostic confirmation is required with microscopic and culture examination. In tinea capitis oral therapy is necessary (minimum six weeks) and should be continued until clinical and, above all, mycological healing...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29036255/tavaborole-in-difficult-to-treat-onychomycosis-cases-a-post-hoc-assessment-of-phase-iii-subjects
#2
Raza Aly, Aditya K Gupta, Tate Winter, Lee T Zane, Tracey Vlahovic
Toenail onychomycosis is a chronic fungal infection that often requires prolonged treatment in order to effectively manage pathogenic organisms and obtain a clear nail. Traditionally, certain clinical features of onychomycosis, including the presence of substantial lateral disease, focal fungal masses, yellow/brown streaks, and extensive nail involvement (ie, >50%), indicate a poor treatment prognosis and have proven difficult-to-treat with oral or traditional topical therapies. Owing to the novel features of topical tavaborole, we sought to understand the potential utility of tavaborole in difficult-to-treat onychomycosis...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28979861/treatment-of-dermatophytosis-in-elderly-children-and-pregnant-women
#3
REVIEW
Subuhi Kaul, Savita Yadav, Sunil Dogra
Dermatophytic infection of the skin and its appendages is a common occurrence. Though usually straightforward, treatment of dermatophytosis becomes notably challenging in certain population groups - pregnant women, children, and elderly. Treatment with topical azoles/allylamines alone is effective in limited cutaneous disease in all three groups. Terbinafine is the preferred oral agent in elderly population for treatment of extensive cutaneous disease and onychomycosis due to its lack of cardiac complications and lower propensity for drug interactions...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28979665/1340nm-laser-therapy-for-onychomycosis-negative-results-of-prospective-treatment-of-72-toenails-and-a-literature-review
#4
Graciela Araújo Do Espírito-Santo, Diniz Pereira Leite, Hugo Dias Hoffmann-Santos, Luciana Basili Dias, Rosane Christine Hahn
Onychomycosis is an infection of the nail plate by fungal microorganisms. This infection has an important social impact on women and men and poses a major challenge for its treatment. The traditional treatment of onychomycosis involves the use of topical and oral antifungal agents. However, the presence of adverse effects frequently associated with oral antifungals, their high cost, and their potential interactions with other drugs reflect some of the problems associated with conventional therapy. The current report details the evaluation of a 1340nm laser as monotherapy for toenails affected by onychomycosis...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28978624/oral-antifungals-for-toenail-onychomycosis
#5
(no author information available yet)
No abstract text is available yet for this article.
October 4, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28975806/antibiofilm-activity-of-propolis-extract-on-fusarium-species-from-onychomycosis
#6
Juliana Galletti, Flávia K Tobaldini-Valerio, Sónia Silva, Érika Seki Kioshima, Larissa Trierveiler-Pereira, Marcos Bruschi, Melyssa Negri, Terezinha Inez Estivalet Svidzinski
AIM: The present study evaluated the capacity of three species of Fusarium isolated from onychomycosis to form biofilms and the antibiofilm effect of propolis extract on these biofilms. MATERIALS & METHODS: The biofilms and antibiofilm effects were evaluated by quantifying the colony-forming units, mitochondrial metabolic activity assays, total biomass by crystal violet staining and scanning electron microscopy. RESULTS: Propolis extract demonstrated significant antibiofilm efficiency on Fusarium spp...
October 4, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28963202/draft-genome-sequences-of-trichophyton-rubrum-cmcc-f-t1i-and-trichophyton-violaceum-cmcc-f-t3l-by-illumina-2000-and-pacific-biosciences
#7
Ping Zhan, Sybren de Hoog, Weida Liu
One strain of Trichophyton rubrum CMCC(F)T1i (=CBS 139224) isolated from onychomycosis and one strain of Trichophyton violaceum CMCC(F)T3l (=CBS 141829) isolated from tinea capitis in China were whole-genome sequenced by Illumina/Solexa, while the former was also sequenced by Pacific Biosciences sequencing in parallel.
September 28, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28954534/confirmatory-testing-prior-to-initiating-onychomycosis-therapy-is-cost-effective
#8
Aditya K Gupta, Sarah G Versteeg, Neil H Shear
BACKGROUND: Onychomycosis can be investigated by sampling. Information gleaned includes nail bed involvement, nail plate penetration, fungal viability, and species identification. Testing samples can confirm a diagnosis. While diagnostic testing is considered useful in directing therapy, a substantial number of clinicians do not confirm diagnosis prior to treatment. OBJECTIVES: The aim of this study is to quantify the benefit of confirmatory testing prior to treating toenail onychomycosis...
September 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28947288/vinegar-sock-soak-for-tinea-pedis-or-onychomycosis
#9
Steven Kelly, Deede Liu, Tang Wang, Anand Rajpara, Catherine Franano, Daniel Aires
No abstract text is available yet for this article.
September 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28947281/weight-change-and-risk-of-onychomycosis-a-nationwide-cohort-study-from-korea
#10
Seong Jun Ha, Kyung Do Han, Yumee Song, Ji Hyun Lee
No abstract text is available yet for this article.
September 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28940733/in-vitro-biofilms-and-antifungal-susceptibility-of-dermatophyte-and-non-dermatophyte-molds-involved-in-foot-mycosis
#11
Nourchéne Toukabri, Serena Corpologno, Marie-Elisabeth Bougnoux, Dalenda El Euch, Najla Sadfi-Zouaoui, Giovanna Simonetti
BACKGROUND: Tinea pedis and onychomycosis are among the commonest fungal diseases in the world. Dermatophytes and, less frequently, non-dermatophyte molds are etiological agents of foot mycosis and could be able to form biofilms. Fungal biofilm has demonstrated increasing drug resistance OBJECTIVES: This work aims to evaluate in vitro the ability to form biofilm and the susceptibility to antifungal drugs of sessile dermatophytes and non-dermatophyte molds involved in foot mycosis. Methods Thirty-six dermatophytes and non-dermatophyte molds isolated from Tunisian patients with foot mycoses, and identified with MALDI-TOF have been tested...
September 22, 2017: Mycoses
https://www.readbyqxmd.com/read/28925059/patient-reported-outcomes-from-two-randomised-studies-comparing-once-weekly-application-of-amorolfine-5-nail-lacquer-to-other-methods-of-topical-treatment-in-distal-and-lateral-subungual-onychomycosis
#12
Martin Schaller, Bardur Sigurgeirsson, Marlis Sarkany
Patient adherence is a key consideration in the choice of a topical regimen for the treatment of onychomycosis. The objective of this study was to investigate patient-reported outcomes (treatment utilisation, adherence and satisfaction) in onychomycosis treated with once-weekly amorolfine 5% nail lacquer versus once-daily ciclopirox 8% nail lacquer (Study A) or once-daily urea 40% ointment/bifonazole 1% cream combination regimen (Study B). Study A: Subjects received amorolfine and ciclopirox on opposite feet for 12 weeks...
September 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28923039/a-pilot-single-centre-double-blind-placebo-controlled-randomized-parallel-study-of-calmagen%C3%A2-dermaceutical-cream-and-lotion-for-the-topical-treatment-of-tinea-and-onychomycosis
#13
RANDOMIZED CONTROLLED TRIAL
Manoj Parekh, Girisha Ramaiah, Prachi Pashilkar, Ranjani Ramanujam, Peter Johnston, Leodevico L Ilag
BACKGROUND: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis)...
September 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28919705/new-insight-into-the-pathogenesis-of-nail-psoriasis-and-overview-of-treatment-strategies
#14
REVIEW
Alessandra Ventura, Mauro Mazzeo, Roberta Gaziano, Marco Galluzzo, Luca Bianchi, Elena Campione
Psoriasis is a chronic inflammatory disease affecting up to 3% of the general population. The prevalence of nail involvement in psoriasis patients varies between 15% and 79%. While the nails represent a small portion of the body surface area, psoriasis in these areas can have a disproportionate influence on a patient's physical and psychosocial activities. Differential diagnosis between an onychomycosis and a psoriatic nail could be challenging; nevertheless, coexistence of onychomycosis and nail psoriasis also occurs and both are common disorders in the general population...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28906086/new-formulation-for-topical-treatment-of-onychomycoses
#15
Elisa M Difonzo, Federica Scarfì, Massimiliano Galeone
BACKGROUND: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28902946/the-association-between-low-grade-systemic-inflammation-and-skin-diseases-a-cross-sectional-survey-in-the-northern-finland-birth-cohort-1966
#16
Suvi-Päivikki Sinikumpu, Laura Huilaja, Juha Auvinen, Jari Jokelainen, Katri Puukka, Aimo Ruokonen, Markku Timonen, Kaisa Tasanen
Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population...
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28894295/reversible-naftifine-induced-carotenoid-depigmentation-in-rhodotorula-mucilaginosa-a-j%C3%A3-rg-f-c-harrison-causing-onychomycosis
#17
Augustin C Moț, Marcel Pârvu, Alina E Pârvu, Oana Roşca-Casian, Nicoleta E Dina, Nicolae Leopold, Radu Silaghi-Dumitrescu, Cristina Mircea
Rhodotorula mucilaginosa was isolated from a patient with onychomycosis, and identification was confirmed by morphological and cultural characteristics as well as by DNA molecular analysis. Antifungal agents naftifine (10 mg/mL, active substance in Exoderil) and bifonazole (10 mg/mL, active substance in Canespor) were tested in different concentrations to assess in vitro effects on fungal growth and carotenoid synthesis. The antifungal mechanisms of action of naftifine and bifonazole against R. mucilaginosa isolates were similar and affected the biosynthetic pathway of ergosterol...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887004/-mycological-profile-of-hand-onychomycosis-amongs-garba-sellers-in-abidjan-c%C3%A3-te-d-ivoire
#18
P C M Kiki-Barro, A Konaté, F K Kassi, E K Angora, H Bosson-Vanga, A V Bedia-Tanoh, V Djohan, W Yavo, E I H Menan
OBJECTIVE: The aim of this study is to determine the prevalence and the fungi involved in onychomycosis located on fingers in Abidjan. MATERIAL AND METHODS: This study includes the sellers of cooked cassava semolina served with fried tuna fish called "garba". Fines squames specimen was processed with 30% KOH for a direct microscope examination. Serous collection were done in physiological serum. Part of the original sample was cultured on Sabouraud medium with antibiotics (chloramphénicol, actidione)...
September 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28880601/onychomycosis-infectionsdo-polymerase-chain-reaction-and-culture-reports-agree
#19
Aditya K Gupta, Kerry-Ann Nakrieko
BACKGROUND: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections. METHODS: To measure agreement between culture and PCR methods for identification of infecting species of suspected onychomycosis, single toenail samples from 167 patients and repeated serial samples from 43 patients with suspected onychomycosis were processed by culture and PCR for identification of 16 dermatophytes and five NDMs...
July 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28879191/patient-reported-outcomes-in-onychomycosis-a-review-of-psychometrically-evaluated-instruments-in-assessing-treatment-effectiveness
#20
REVIEW
Jenny Wang, Lauren E Wiznia, Evan A Rieder
PURPOSE: Onychomycosis is the most common nail disorder and causes morbidity and impaired quality of life (QOL). Patient-reported outcomes (PRO) are patients' assessment of their health status or treatment response. PROs help assess what is most bothersome to patients to identify targets for intervention. We sought to review the PRO instruments currently used to assess QOL and treatment response in onychomycosis patients. PROCEDURES: A systematic review was performed by searching PubMed, Embase, CINAHL, and PsycINFO databases through December 31, 2016, to identify all English language literature on onychomycosis, PRO, and QOL...
August 2017: Skin Appendage Disorders
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