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Onychomycosis

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https://www.readbyqxmd.com/read/29227574/light-treatments-of-nail-fungal-infections
#1
REVIEW
Jessica Houang, Gabriel Perrone, Damia Mawad, Philip C Boughton, Andrew J Ruys, Antonio Lauto
Nail fungal infections are notoriously persistent and difficult to treat which can lead to severe health impacts, particularly in the immunocompromised. Current antifungal treatments, including systemic and topical drugs, are prolonged and do not effectively provide a complete cure. Severe side effects are also associated with systemic antifungals, such as hepatoxicity. Light treatments of onychomycosis are an emerging therapy that has localised photodynamic, photothermal or photoablative action. These treatments have shown to be an effective alternative to traditional antifungal remedy with comparable or better cure rates achieved in shorter times and without systemic side effects...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29200757/randomized-clinical-trial-to-evaluate-the-efficacy-and-safety-of-combination-therapy-with-short-pulsed-1-064-nm-neodymium-doped-yttrium-aluminium-garnet-laser-and-amorolfine-nail-lacquer-for-onychomycosis
#2
Kui Young Park, Joon Hyuk Suh, Beom Joon Kim, Myeung Nam Kim, Chang Kwun Hong
Background: Onychomycosis is one of the most prevalent fungal diseases in the general population. However, treatment is of limited effectiveness and must be administered for long periods of time. Systemic antifungal agents are associated with adverse effects. Objective: We evaluated the clinical efficacy and safety of a 1,064-nm neodymium-doped yttrium aluminium garnet (Nd:YAG) laser with amorolfine nail lacquer to treat onychomycosis. Methods: The 128 patients were randomly divided to 2 groups: 64 in the experimental group were treated with 1,064-nm Nd:YAG laser therapy and amorolfine nail lacquer; the other 64 were in a control group treated with topical amorolfine lacquer monotherapy...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29198426/luliconazole-a-new-antifungal-against-candida-species-isolated-from-different-sources
#3
S Taghipour, N Kiasat, S Shafiei, M Halvaeezadeh, A Rezaei-Matehkolaei, A Zarei Mahmoudabadi
OBJECTIVE: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials...
November 29, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29193594/complete-cure-of-fusarium-solani-sp-complex-onychomycosis-with-qs-ndyag-treatment
#4
Ananta Khurana, Anuradha Chowdhary, Kabir Sardana, R K Gautam, P K Sharma
The incidence of non dermatophytic mould (NDM) onychomycosis (OM) has been steadily increasing Fusarium spp is the most common cause of NDM OM in most geographical locations. Fusarium spp and other NDMs are largely resistant to commonly used anti-fungals. The successful use of laser and light based devices has been demonstrated in dermatophytic OM, but there is no previous report of their successful use in any NDM OM. We describe a patient with OM caused by Fusarium solani spp, who was clinically (with a normal appearing nail) and mycologically (with negative microscopy and culture on repeated samples) cured of her infection following treatment with 2 sessions of Qs NdYAG (532nm and 1064nm) given 1 month apart...
November 28, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29193377/evaluation-of-a-new-fluorescent-reagent-fluorescent-brightener-85-for-the-diagnosis-of-suspected-onychomycosis-compared-with-potassium-hydroxide
#5
Xueping Yue, Aiping Wang, Hongwei Wang, Qing Li, Xiuling Yue
BACKGROUND: Onychomycosis is a common fungal infection in dermatology clinics. The commonly used diagnostic method, potassium hydroxide (KOH) direct microscopy, does not have a high positive detection rate. Therefore, a new diagnostic method is needed to confirm onychomycosis. OBJECTIVES: The objective of this research was to use fluorescent brightener 85 (FB 85), a new fluorescent reagent for fungi detection, and to evaluate this new method based on the diagnostic positive rate, accuracy and efficiency in suspected onychomycosis compared with the KOH method...
November 29, 2017: Mycoses
https://www.readbyqxmd.com/read/29191054/onychomycosis-and-chronic-fungal-disease-exploiting-a-commensal-disguise-to-stage-a-covert-invasion
#6
Aditya K Gupta, Jessie Carviel, Neil H Shear
Onychomycosis is a chronic fungal infection that is recalcitrant to treatment and often results in relapse. New evidence suggests that disease prognosis may be linked to pathogens manipulating host immune responses. Therefore, individuals with specific mutations, including those affecting pattern recognition receptors or the interleukin (IL)-17 and IL-22 pathways, may be more susceptible to infection. Moreover, it is recommended that those with a family history of immune mutations or predisposition to fungal disease be treated aggressively for onychomycosis prior to symptom progression...
November 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29188282/laboratory-monitoring-during-systemic-terbinafine-therapy-for-pediatric-onychomycosis
#7
Deepa Patel, Leslie A Castelo-Soccio, Adam I Rubin, Jenna L Streicher
No abstract text is available yet for this article.
November 29, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29188057/subungual-onychomycosis-due-to-aspergillus-niger-mimicking-a-glomus-tumor-a-case-report
#8
Yumi Matsuyama, Tomoki Nakamura, Tomohito Hagi, Kunihiro Asanuma, Akihiro Sudo
Onychomycosis is a common nail infection caused by dermatophytes, while non-dermatophytes including Aspergillus spp. are causes of nail onychomycosis. Aspergillus niger is not common as a cause of nail onychomycosis. In the current study we present a 60-year-old woman with subungual onychomycosis due to Aspergillus niger mimicking a glomus tumor. Physical examination revealed right thumb had a black color of nail bed. Localized tenderness and severe pain were observed. However, the cold sensitivity test, Loves pin test and Hildreths test were negative...
December 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29187718/-affinity-of-luliconazole-for-human-nail-derived-keratin
#9
Masayuki Hasuko, Ryo Shiomi, Yoshinori Takahashi, Kazuhiko Motoba, Hirofumi Hirano, Ryoji Tsuboi, Katsuhiro Inagaki
 Affinity of Luliconazole (LLCZ), an antifungal drug used for topical treatment of onychomycosis in Japan, to nail keratin was demonstrated. Efinaconazole (EFCZ) was used as a reference drug. Drugs at fixed concentrations were added to 4 ml of buffer solution containing 40 mg of nail keratin powder prepared from healthy volunteers or from tinea unguium patients. The mixtures were shaken at 37℃, and adsorption and desorption rates of the drug in nail keratin were measured. Theoretical analysis using the Freundlich adsorption isotherm was applied to eliminate effects of testing conditions on the results...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/29177757/the-role-of-dermoscopy-in-the-diagnosis-of-distal-lateral-subungual-onychomycosis
#10
Emre Kaynak, Fatih Göktay, Pembegül Güneş, Elif Sayman, Deniz Turan, Arzu Baygül, Sema Aytekin
Recently dermoscopic patterns, that can be useful in the diagnosis of distal and lateral subungual onychomycosis, were identified. In this study, we aimed to determine the frequency of the defined patterns so far and additionally to identify other patterns that were observed and to investigate the place of these patterns in the diagnosis of Distal Lateral Subungual Onychomycosis (DLSO) in the dermoscopic examination of the patients with pre-diagnosis of DLSO. Patients admitted dermatology outpatient clinic of Haydarpasa Numune Training and Research Hospital with the complaint of nail disturbance suspicious for DLSO (97 patients) between the August 2015 and February 2016...
November 24, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29164433/distal-lateral-subungual-onychomycosis-owing-to-tritirachium-oryzae-a-bystander-or-invader
#11
Hari Pankaj Vanam, P Narsimha Rao, Kalyani Mohanram, Prakash Peralam Yegneswaran, Shiva Prakash Mandya Rudramurthy
The genus Tritirachium is a mitosporic fungus which inhabits in soil and decaying plant material and also a notable insect pathogen. Human infections with Tritirachium species though rare were previously reported to cause corneal ulcers, otomycosis, onychomycosis, and dermatomycosis of the scalp and hence may be considered as a potential pathogen. Here we report a case of distal lateral subungual onychomycosis involving right great toenail in a 22-year-old female, wherein direct potassium hydroxide preparations, fungal cultures, and molecular sequencing of the isolate established Tritirachium oryzae as the etiological agent...
November 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29147866/a-review-of-onychomycosis-due-to-aspergillus-species
#12
REVIEW
Felix Bongomin, C R Batac, Malcolm D Richardson, David W Denning
Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. have recently been described to cause nail infections. The following criteria are required to diagnose onychomycosis due to Aspergillus spp.: (1) positive direct microscopy and (2) repeated culture or molecular detection of Aspergillus spp., provided no dermatophyte was isolated. A review of 42 epidemiological studies showed that onychomycosis due to Aspergillus spp. varies between < 1 and 35% of all cases of onychomycosis in the general population and higher among diabetic populations accounting for up to 71% and the elderly; it is very uncommon among children and adolescence...
November 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29141535/sln-and-nlc-encapsulating-antifungal-agents-skin-drug-delivery-and-their-unexplored-potential-for-treating-onychomycosis
#13
Tais Gratieri, Anna Paula Krawczyk-Santos, Priscila Bianca Rodrigues da Rocha, Marcilio Cunha-Filho, Guilherme Martins Gelfuso, Ricardo Neves Marreto, Stephania Fleury Taveira
BACKGROUND: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. METHODS: We therefore compare skin and nail physiopathological structure and discuss the potential use of lipid nanoparticles in managing skin and nail mycoses, highlighting their unexplored use in onychomycosis...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29138987/optimized-ciclopirox-based-eudragit-rlpo-nail-lacquer-effect-of-endopeptidase-enzyme-as-permeation-enhancer-on-transungual-drug-delivery-and-efficiency-against-onychomycosis
#14
Abeer Khattab, Samia Shalaby
The aims of our investigation were to develop and optimize ciclopirox (CPX) nail lacquer using nonbiodegradable Eudragit RLPO (E-RLPO) as a film former and to assess its penetration efficiency across the human nail plate. Preliminary trials such as hydration enhancement factor (HEF), a retained drug in the nail plate, and SEM were studied to select the optimized permeation enhancer to be incorporated in the optimized lacquer formulation. A 3(3) full factorial design was built up to study the effect of three different factors, concentration of E-RLPO (10, 20, and 30%), Tween 80 (0...
November 14, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29136060/clinical-trial-designs-for-topical-antifungal-treatments-of-onychomycosis-and-implications-on-clinical-practice
#15
Phoebe Rich, Tracey C Vlahovic, Warren S Joseph, Lee T Zane, Steve B Hall, Nicole Gellings Lowe, Chris G Adigun
There currently are 3 topical agents approved by the US Food and Drug Administration (FDA) to treat onychomycosis: tavaborole, efinaconazole, and ciclopirox. The phase 3 clinical trial designs for these treatments and their notable differences make it difficult for clinicians to interpret the data into clinical practice. For example, the primary end point predominantly used to assess efficacy in all the trials is complete cure, defined as no involvement of the nail plus mycologic cure; also, a notable number of patients fail to achieve a complete cure despite clear improvement in the nail...
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29126627/-clinical-and-mycological-characteristics-of-onychomycosis-due-to-candida-at-institut-pasteur-of-c%C3%A3-te-d-ivoire
#16
K E Angora, A Ira-Bonouman, A H Vanga-Bosson, A Konaté, F K Kassi, K Tuo, K Sylla-Thanon, P C Kiki-Barro, S Miezan, A V Bedia-Tanoh, V Djohan, W Yavo, E H Menan, A T Offianan
OBJECTIVE: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire. PATIENTS AND METHODS: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded. RESULTS: In this study, 1898 patient files were selected...
November 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29110252/risk-of-psoriasis-following-terbinafine-or-itraconazole-treatment-for-onychomycosis-a-population-based-case-control-comparative-study
#17
Hsien-Yi Chiu, Wei-Lun Chang, Tsen-Fang Tsai, Yi-Wen Tsai, Ming-Neng Shiu
INTRODUCTION: Several case studies have reported an association between antifungal drug use and psoriasis risk. OBJECTIVE: The objective of this study was to investigate the association between terbinafine/itraconazole exposure and psoriasis incidence. METHODS: Among patients with onychomycosis in the Taiwan National Health Insurance Research Database, 3831 incident psoriasis cases were identified during 2004-2010 and compared with 3831 age- and sex-matched controls with the same look-back period...
November 6, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29091566/hiv-infection-manifesting-as-proximal-white-onychomycosis
#18
Elisabeth Gómez-Moyano, Vicente Crespo-Erchiga
A 48-year-old-man presented to the dermatology clinic with a whitish discoloration and hyperkeratosis of the first toenail that had extended from the proximal to the distal nail during the past month (Panel A). The patient reported no history of trauma to the nail. He had no fever, weight loss,..
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29078738/clinico-aetiologic-profile-of-onychomycoses-in-a-tertiary-care-centre-in-northeast-india
#19
Amit Banik, Elantamilan Durairaj, W V Lyngdoh, Annie B Khyriem, Debahuti Sabhapandit
Onychomycosis refers to fungal nail infection. Despite a clearly diseased appearance, it is often deemed a merely cosmetic problem of relatively minor importance. However, it may result in much psychological or occupational turmoil, diminished self-esteem and resulting reluctance for public interaction. A wide number of factors determine the treatment outcome and its prevalence varies greatly. Our study was conducted between January 2011 and December 2014 in northeast India. Of 243 patients presenting with nail abnormalities, 158 (65%) were positively diagnosed by either direct microscopy or culture or both...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29077504/point-of-care-diagnosis-of-onychomycosis-by-dermoscopy
#20
Myron A Bodman
BACKGROUND: Onychomycosis is one of the most common diseases of the toenails. The costs of diagnosis and treatment are substantial, and as the population ages, the overall cost burden will continue to escalate. The purpose of this study was to correlate dermoscopic features with pathologic diagnosis to support the accuracy of point-of-care diagnosis by dermoscopic examination. METHODS: Nail unit pathology reports of 52 patients with abnormal great toenails were compared with the dermoscopic features detected by nail unit dermoscopy...
September 2017: Journal of the American Podiatric Medical Association
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