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Onychomycosis

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https://www.readbyqxmd.com/read/28225975/descriptive-analysis-of-mycological-examination-of-patients-with-onychomycosis-treated-in-private-practice
#1
John Verrinder Veasey, Flávio Nappi, Clarisse Zaitz, Laura Hitomi Muramatu
This is a retrospective study of 160 patients treated in private practice in São Paulo from March 2003 to March 2015. We analyzed 171 results of direct mycological examinations and fungal cultures from nail scrapings. The agreement between direct mycological examination results and fungal culture was satisfactory, consistent with the literature (kappa 0.603). The main agent identified was Trichophyton rubrum (51%). We observed an isolation rate of non-dermatophyte filamentous fungi superior to the literature (34%)...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28222676/meta-analysis-of-the-utility-of-culture-biopsy-and-direct-koh-examination-for-the-diagnosis-of-onychomycosis
#2
Verónica Velasquez-Agudelo, Jaiberth Antonio Cardona-Arias
BACKGROUND: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. METHODS: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies...
February 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28217436/the-first-report-of-onychomycosis-caused-by-cryptococcus-friedmannii-naganishia-friedmannii-a-basidiomycetous-yeast
#3
Masoome Ekhtiari, Shirin Farahyar, Mehraban Falahati, Elham Razmjou, Mahtab Ashrafi-Khozani, Zeinab Ghasemi, Ziba Abbasi-Nejat
Yeasts are common etiologic agents of onychomycosis. This study reported a case of onychomycosis due to Cryptococcus friedmannii (Naganishia friedmannii). This yeast was isolated of the right great toenail of 57-year-old man. Microscopic examination of nail scrapings showed budding cells with thin capsule. Sequence analyzes of the internal transcribed spacer regions was closely related to Cryptococcus friedmannii. The results of susceptibility testing showed the Cryptococcus friedmannii to be sensitive to fluconazole, itraconazole and amphotericin B...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28210388/topical-treatment-for-onychomycosis-is-it-more-effective-than-the-clinical-data-suggests
#4
REVIEW
Boni E Elewski, Tracey C Vlahovic, Andrew Korotzer
Background: The current definition of complete cure is considered too stringent to reflect the true benefit of onychomycosis treatment seen in general practice and may limit the use of newer topical agents in mild-to-moderate disease. In addition, outcomes reported in clinical trials do not consistently report secondary endpoints, making data comparison difficult. Methods: The authors review the clinical data reported on two new topical antifungals, efinaconazole and tavaborole, in light of the latest thinking of more practical approaches to assess improvement and treatment success...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28188648/pilot-study-to-evaluate-a-plasma-device-for-the-treatment-of-onychomycosis
#5
S R Lipner, G Friedman, R K Scher
Onychomycosis is a fungal infection of the nail unit, and is the most common of the nail disorders. Current therapies for onychomycosis have less than ideal efficacy and have the potential for adverse effects. As previous studies have shown that nonthermal plasma inhibits the in vitro growth of Trichophyton rubrum, we conducted a pilot study on 19 participants with toenail onychomycosis. The primary endpoint was safety of the device, and secondary outcome measures were clinical efficacy and mycological cure...
February 11, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28188051/incidence-and-biodiversity-of-yeasts-dermatophytes-and-non-dermatophytes-in-superficial-skin-infections-in-assiut-egypt
#6
A H Moubasher, M A Abdel-Sater, Z Soliman
OBJECTIVE: The aim was to identify the incidence of the causal agents from dermatophytes, non-dermatophytes and yeasts in Assiut Governorate employing, beside the morphological and physiological techniques, the genotypic ones. PATIENTS: Samples from infected nails, skin and hair were taken from 125 patients. MATERIALS AND METHODS: Patients who presented with onychomycosis, tinea capitis, tinea corporis, tinea cruris and tinea pedis during the period from February 2012 to October 2015 were clinically examined and diagnosed by dermatologists and were guided to Assiut University Mycological Centre for direct microscopic examination, culturing and identification...
February 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28160226/molecular-diagnostic-techniques-for-onychomycosis-validity-and-potential-application
#7
Shinichi Watanabe, Kazuya Ishida
BACKGROUND: Diagnosis of onychomycosis requires positive findings by direct microscopy and fungal culture. Fungal culture is slow and difficult, with low yields. We compared two dermatophyte identification methods, one using a real-time polymerase chain reaction (PCR) method, and the other using fungal culture to validate the molecular method. METHODS: Nail specimens were collected from 149 patients with distal and lateral subungual onychomycosis who were positive for fungal elements by direct microscopy using potassium hydroxide...
February 4, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28134122/pseudo-onychomycosis
#8
Mitsuhito Ota
No abstract text is available yet for this article.
February 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28128500/pdt-for-onychomycosis
#9
L R Braathen
No abstract text is available yet for this article.
February 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28116600/transungual-gel-of-terbinafine-hydrochloride-for-the-management-of-onychomycosis-formulation-optimization-and-evaluation
#10
Purva Thatai, Bharti Sapra
The present study was aimed to optimize, develop, and evaluate microemulsion and microemulsion-based gel as a vehicle for transungual drug delivery of terbinafine hydrochloride for the treatment of onychomycosis. D-optimal mixture experimental design was adopted to optimize the composition of microemulsion having amount of oil (X 1), Smix (mixture of surfactant and cosurfactant; X 2), and water (X 3) as the independent variables. The formulations were assessed for permeation (micrograms per square centimeter per hour; Y 1), particle size (nanometer; Y 2), and solubility of the drug in the formulation (milligrams per milliliter; Y 3)...
January 23, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28101694/relationship-between-phenotypic-and-genotypic-characteristics-of-trichophyton-mentagrophytes-strains-isolated-from-patients-with-dermatophytosis
#11
I Dhib, I Khammari, A Yaacoub, F Hadj Slama, M Ben Saïd, R Zemni, A Fathallah
According to epidemiological, clinical and mycological criteria, it has long been admitted that the Trichophyton mentagrophytes species includes two varieties: a zoophilic variety (var. mentagrophytes) and an anthropophilic variety (var. interdigitale) that involve the upper and the lower part of the body, respectively. The further application of molecular techniques to the characterization of dermatophyte strains showed that this classification is unreliable. The aim of our study was to assess the usefulness of PCR-RFLP (restriction fragment length polymorphism) and sequencing in the characterization of T...
January 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28099608/subungual-squamous-cell-carcinoma
#12
Carolina Barbosa de Sousa Padilha, Laila Klotz de Almeida Balassiano, Julyana Calegari Pinto, Flávia Crespo Schueler de Souza, Bernard Kawa Kac, Curt Mafra Treu
Although subungual squamous cell carcinoma is rare, it is the most common primary malignant neoplasms in this location. The higher incidence occurs in the fingernails, but involvement of the toenails is also possible. Subungual squamous cell carcinoma often looks like other more common benign lesions, such as fungal infection, onychomycosis, or viral wart. These factors, together with a general lack of awareness of this disease among physicians, often result in delayed diagnosis. Therefore, it is underdiagnosed, with few reports in the literature...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28097731/efficacy-and-tolerability-of-amorolfine-5-nail-lacquer-in-combination-with-systemic-antifungal-agents-for-onychomycosis-a-meta-analysis-and-systematic-review
#13
REVIEW
Xiaowei Feng, Xincai Xiong, Yuping Ran
The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. It showed that the experimental combination group was more effective than monotherapy of the systemic antifungals [OR (odds ratio) = 1.97, 95%CI (95% confidence interval) = 1...
January 18, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28063967/an-innovative-polysaccharide-nanobased-nail-formulation-for-improvement-of-onychomycosis-treatment
#14
Fernanda C Flores, Roberta S Rosso, Letícia Cruz, Ruy C R Beck, Cristiane B Silva
Tioconazole-loaded nanocapsule suspensions and its coating with a cationic polymer were developed for nail drug delivery. The colloidal systems presented a nanometric size around 155nm for uncoated nanoparticles and 162nm for those with the cationic coating, with negative and positive zeta potential values, respectively. Both nanosuspensions showed drug content close to theoretical values (1mgmL(-1)), association efficiency close to 100% (HPLC) and were able to control tioconazol release. The developed formulations showed in vitro antifungal activity (agar diffusion method) against C...
January 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28061322/long-pulsed-1064-nm-nd-yag-laser-for-the-treatment-of-onychomycosis
#15
Domenico Piccolo, Dimitra Kostaki, Ester Del Duca, Giovanni Cannarozzo, Mario Sannino, Steven Nisticò
OBJECTIVE: The aim of this study is to evaluate the efficacy of long-pulsed 1064-nm Nd:YAG laser in penetrating tissue and targeting the fungal overgrowth in the nail plate. BACKGROUND: Onychomycosis is the most frequent nail disorder. Current treatments include oral and topical antifungal agents, photodynamic therapy, and surgical approaches such as mechanical, chemical, or surgical nail avulsion. Moreover, the use of lasers to treat nail diseases has been approved in the United States by the Food and Drug Administration (FDA)...
December 30, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28040821/over-the-counter-and-natural-remedies-for-onychomycosis-do-they-really-work
#16
Pierre Halteh, Richard K Scher, Shari R Lipner
Onychomycosis is a fungal infection of the nail unit that may lead to dystrophy and disfigurement over time. It accounts for up to 50% of all nail conditions, with toenails affected more commonly than fingernails. Onychomycosis may affect quality of life and increase the prevalence and severity of foot ulcers in patients with diabetes. Available oral agents approved by the US Food and Drug Administration (FDA) for the treatment of onychomycosis include terbinafine and itraconazole, which have demonstrated good efficacy but are associated with the risk of systemic side effects and drug-drug interactions...
November 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28040418/-trichophyton-tonsurans-associated-with-non-albicans-candida-species-in-hands-onychomycosis-about-a-moroccan-case
#17
S Kouara, B Ait Hlilou, A Abbadi, H Khalki, I Benbella, K Lahmadi, M Er-Rami
INTRODUCTION: Trichophyton tonsurans is an anthropophilic dermatophyte, frequent in the USA and in Asia where it is responsible for causing tinea capitis. At present, we attend an emergence of this species in certain regions where it was not or little met. Here, we report a case of onychomycosis of the hand due to T. tonsurans associated with non-albicans Candida species at an adult woman. OBSERVATION: The patient is a 62-year-old woman, with hypertension and diabetes...
December 28, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28034734/preparation-and-evaluation-of-a-novel-dosage-form-for-onychomycosis
#18
Flavia Laffleur, Martin Ataii
Onychomycosis is a common infection of the nail caused by dermatophyte affecting mostly toenails in adults being associated with limited treatment options. In this study novel dosage forms were prepared and evaluated for their suitability in treatment of onychomycosis. Films were prepared comprising polymeric excipients such as chitosan, (hydroxypropyl)methyl cellulose, hydroxyethyl-cellulose, carboxymethylcellulose according to solvent evaporation method. Developed formulations were evaluated in terms of physical appearance, stability and adhesiveness...
December 26, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28012546/proximal-subungual-onychomycosis-due-to-aspergillus-niger-a-simulator-of-subungual-malignant-melanoma
#19
M Álvarez-Salafranca, S Hernández-Ostiz, S Salvo Gonzalo, M Ara Martín
No abstract text is available yet for this article.
December 21, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28004227/trichophyton-rubrum-infection-characterized-by-majocchi-s-granuloma-and-deeper-dermatophytosis-case-report-and-review-of-published-literature
#20
Huilin Su, Li Li, Benlin Cheng, Junhao Zhu, Qiangqiang Zhang, Jinhua Xu, Min Zhu
Infections caused by Trichophyton rubrum are very common in dermatological disease. It most often appears as superficial cutaneous mycosis, such as tinea manuum, tinea pedis, and tinea corporis. However, deep infection caused by T. rubrum was rarely reported. We describe a case of mixed type of deep infection caused by T. rubrum in a 45-year-old man with no significant immunodeficiency. This patient had a history of onychomycosis on the toenails without regular treatment for nearly 6 years. And, he had erythema, papule, and nodules on the submandibular area, neck, and chest for almost 1 year...
December 21, 2016: Mycopathologia
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