Read by QxMD icon Read


Aditya K Gupta, Andrew Korotzer
BACKGROUND: Although a completely normal nail would be the ideal outcome when treating onychomycosis, this is not always achievable and long treatment courses or patient expectations can impact patient adherence. METHODS: We analyzed cure rates from a number of subpopulations derived from the two pivotal phase III studies with efinaconazole topical solution (10%) to provide some insights into clinically meaningful treatment outcomes and support for effective long-term management programs...
October 1, 2016: Journal of Drugs in Dermatology: JDD
Tamara Angelo, Lívia Neves Borgheti-Cardoso, Guilherme Martins Gelfuso, Stephânia Fleury Taveira, Tais Gratieri
Onychomycosis is a fungal infection of the fingernails or toenails caused by dermatophytes, nondermatophytes, moulds, and yeasts. This condition affects around 10-30% people worldwide, negatively influencing patients' quality of life, with severe outcomes in some cases. Since the nail unit acts as a barrier to exogenous substances, its physiological features hampers drug penetration, turning the onychomycosis treatment a challenge. Currently, there are several oral and topical therapies available; nevertheless, cure rates are still low and relapse rates achieves 10-53%...
October 4, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Christine R Totri, Stephanie Feldstein, Shehla Admani, Sheila F Friedlander, Lawrence F Eichenfield
BACKGROUND: Onychomycosis (OM) is thought to be a rare disease in children, although there are few epidemiologic studies. METHODS: This 3-year retrospective case series of nearly 400 children seen at Rady Children's Hospital-San Diego (RCHSD) describes the characteristics of OM found in this pediatric population. RESULTS: From 2011 to 2013, the Pediatric and Adolescent Dermatology Clinic at RCHSD saw a total of 36,634 unique patients, of whom 433 were unique patients with OM...
October 4, 2016: Pediatric Dermatology
Dongmei Shi, Guixia Lu, Huan Mei, G Sybren de Hoog, Hailin Zheng, Guanzhao Liang, Yongnian Shen, Tianhang Li, Weida Liu
Onychomycosis is usually caused by dermatophytes, although also other filamentous and yeast-like fungi are associated with nail invasion. Chaetomium is an environmental genus of ascomycetes exhibiting a certain degree of extremotolerance. We report the first case of onychomycosis in a 46-year-old woman in China caused by Chaetomium globosum. The patient showed yellowish black discoloration with periungual inflammation on the left first toenail. We confirmed the causative agent, C. globosum, by KOH mount, culture, micromorphology and DNA sequence analysis...
September 2016: Medical Mycology Case Reports
Alina Tanase, Anca Colita, Gabriel Ianosi, Daniela Neagoe, Daciana Elena Branisteanu, Daniela Calina, Anca Oana Docea, Aristidis Tsatsakis, Simona Laura Ianosi
Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft-vs.-host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease...
October 2016: Experimental and Therapeutic Medicine
Aditya K Gupta, Kelly A Foley, Deanne Daigle
BACKGROUND: Despite the fact that lasers are presently indicated for the cosmetic outcome "temporary increase in clear nail", these devices are increasingly used to treat onychomycosis and particularly in patients who are unwilling or unable to take oral antifungal medication. The US Food and Drug Administration (FDA) recently issued draft guidance for medical device trials for onychomycosis. OBJECTIVE: This review evaluates the quality of laser trials for onychomycosis and compares the design guidelines for medical devices and antifungal drugs...
August 10, 2016: Journal of Dermatological Treatment
James Q Del Rosso
Topical antifungal management of toenail onychomycosis has been fraught with several therapeutic challenges including difficulty gaining access to the site of infection and the need for prolonged durations of therapy. In addition, there has been a marked lack of information on the impact of toenail polish application on drug penetration after application. This article reviews available data from studies evaluating the effect of nail polish on antifungal drag penetration using ex vivo laboratory models with cadaver fingernail plates with both tavaborole 5% solution and efinaconazole 10% solution...
August 2016: Journal of Clinical and Aesthetic Dermatology
Andrea G Varon, Simone A Nouér, Gloria Barreiros, Beatriz Moritz Trope, Tiyomi Akiti, Marcio Nucci
Hematologic patients with superficial skin lesions on admission growing Fusarium spp. are at high risk to develop invasive fusariosis during neutropenia. We evaluated the impact of primary prophylaxis with a mold-active azole in preventing the occurrence of invasive fusariosis in these patients. From August 2008 to December 2014, patients with acute leukemia, aplastic anemia, or recipients of hematopoietic cell transplantation were screened on admission with dermatologic examination and direct exam and fungal culture of superficial skin lesions...
September 26, 2016: Antimicrobial Agents and Chemotherapy
Yasemin Oz, Iman Qoraan, Ali Oz, Ilknur Balta
BACKGROUND: Diabetes patients are particularly susceptible to fungal infections because their vascular and immunological systems are compromised. OBJECTIVES: The present study aimed to determine prevalences of tinea pedis and onychomycosis, factors predisposing to their development, and antifungal susceptibilities of causative fungal species against fluconazole, itraconazole, and terbinafine in patients with type 2 diabetes mellitus (DM). METHODS: Study groups were defined according to hemoglobin A1C rates of ≥6...
September 26, 2016: International Journal of Dermatology
W P Silva-Rocha, M F de Azevedo, G M Chaves
OBJECTIVE: Dermatomycoses are superficial fungal infections which affect the skin, hair and nails of humans and animals. Male and female patients of all ages are affected by this condition. The main etiological agents of dermatomycoses are the dermatophytes fungi of the genera Trichophyton, Microsporum and Epidermophyton, while the main yeasts belong to the genera Candida, Malassezia and Trichosporon. The variation in the distribution of dermatomycoses worldwide justify the conduction of epidemiological studies in order to contribute for the better understanding of patterns of mycological cutaneous infections...
September 20, 2016: Journal de Mycologie Médicale
Arwa M El-Sayed, Marc Karpo, Aisha Jasani, Ebony Love, Lesly Robinson
INTRODUCTION AND OBJECTIVES: Onychomycosis is defined as a fungal infection of the nail usually caused by a dermatophyte. This retrospective study will compare the diagnosis of onychomycosis based on clinical exam findings in comparison to laboratory results. METHODS: Clinical diagnosis of onychomycosis of the nail is made through visual inspection of the nail. The characteristics that define a clinical diagnosis of onychomycosis include but is not limited to: thickness of nail, discoloration (yellow, black, and/or brown), crumbly texture, subungual debris, subungual fluid, splitting of the nail, and/or nail dystrophy...
September 2016: Journal of the American Podiatric Medical Association
Gamze Akkus, Mehtap Evran, Dilek Gungor, Mehmet Karakas, Murat Sert, Tamer Tetiker
OBJECTIVE: Impaired cellular immunity and reduced phagocytic function of polymorphonuclear leukocytes facilitate the development of skin fungal and bacterial infections due to uncontrolled hyperglycemia in diabetic patients. In our study, we aimed to assess onychomycosis and/or tinea pedis frequency in diabetic patients, and effects on the development of chronic complications, particularly foot ulcer. METHODS: We included 227 diabetic patients in the study. Forty-three patients had diabetic foot ulcer...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Meirong Li, Zhuanggui Chen, Songchao Yin, Ruzeng Xue, Zhirui Chen, Huaiqiu Huang, Ling Wei, Chun Lu, Gerit Sybren De Hoog, Wei Lai, Peiying Feng
Onychomycosis is a rare nail disorder in early childhood, while onychomadesis is a periodic idiopathic, non-inflammatory disease that affects the nail matrix and is common in children especially in those who suffer from viral infections. In this study, we investigated recent cases of onychomycosis subsequent to periods of onychomadesis in children. Sixteen young children (six males, 10 females) with a mean age of 36.5 months were diagnosed with onychomadesis, and 13 of the patients had a history of viral infection prior to nail changes...
September 12, 2016: Mycoses
P W Crous, M J Wingfield, D M Richardson, J J Le Roux, D Strasberg, J Edwards, F Roets, V Hubka, P W J Taylor, M Heykoop, M P Martín, G Moreno, D A Sutton, N P Wiederhold, C W Barnes, J R Carlavilla, J Gené, A Giraldo, V Guarnaccia, J Guarro, M Hernández-Restrepo, M Kolařík, J L Manjón, I G Pascoe, E S Popov, M Sandoval-Denis, J H C Woudenberg, K Acharya, A V Alexandrova, P Alvarado, R N Barbosa, I G Baseia, R A Blanchette, T Boekhout, T I Burgess, J F Cano-Lira, A Čmoková, R A Dimitrov, M Yu Dyakov, M Dueñas, A K Dutta, F Esteve-Raventós, A G Fedosova, J Fournier, P Gamboa, D E Gouliamova, T Grebenc, M Groenewald, B Hanse, G E St J Hardy, B W Held, Ž Jurjević, T Kaewgrajang, K P D Latha, L Lombard, J J Luangsa-Ard, P Lysková, N Mallátová, P Manimohan, A N Miller, M Mirabolfathy, O V Morozova, M Obodai, N T Oliveira, M E Ordóñez, E C Otto, S Paloi, S W Peterson, C Phosri, J Roux, W A Salazar, A Sánchez, G A Sarria, H-D Shin, B D B Silva, G A Silva, M Th Smith, C M Souza-Motta, A M Stchigel, M M Stoilova-Disheva, M A Sulzbacher, M T Telleria, C Toapanta, J M Traba, N Valenzuela-Lopez, R Watling, J Z Groenewald
Novel species of fungi described in the present study include the following from Australia: Vermiculariopsiella eucalypti, Mulderomyces natalis (incl. Mulderomyces gen. nov.), Fusicladium paraamoenum, Neotrimmatostroma paraexcentricum, and Pseudophloeospora eucalyptorum on leaves of Eucalyptus spp., Anungitea grevilleae (on leaves of Grevillea sp.), Pyrenochaeta acaciae (on leaves of Acacia sp.), and Brunneocarpos banksiae (incl. Brunneocarpos gen. nov.) on cones of Banksia attenuata. Novel foliicolous taxa from South Africa include Neosulcatispora strelitziae (on Strelitzia nicolai), Colletotrichum ledebouriae (on Ledebouria floridunda), Cylindrosympodioides brabejum (incl...
June 2016: Persoonia
Therdpong Tempark, Ramrada Lekwuttikarn, Susheera Chatproedprai, Siriwan Wananukul
Nail scabies is an interesting clinical presentation of scabies. Although it is usually found concomitant with characteristic dermatologic manifestations, it may present as an isolated finding in the immunocompromised host. This condition is commonly mistaken with other diseases such as nail dystrophy, nail psoriasis and onychomycosis. We report two cases of unusual nail presentations that provide clues to diagnosis. Also, literature on unusual nail and dermatologic presentations was reviewed to recognize dermatologist consideration for appropriate treatment options...
September 9, 2016: Journal of Tropical Pediatrics
Martha Patricia Solís-Arias, Maria Teresa García-Romero
Onychomycosis is considered an age-related infection with increasing prevalence in the older age groups. It is rare in the pediatric population, except in children with Down syndrome and with immunodeficiencies, who are more likely to have fungal nail infections. The number of reports about onychomycosis in children is relatively small, and the epidemiologic data vary, but a rise in prevalence has been demonstrated. In this article, we review the most up-to-date literature and summarize the epidemiology, etiology, clinical presentation, diagnosis, and treatment of onychomycosis in children, as well as the differences with the disease presenting in adults...
September 9, 2016: International Journal of Dermatology
Chris G Adigun, Tracey C Vlahovic, Michael B McClellan, Kailas D Thakker, Ryan R Klein, Tuan A Elstrom, Daniel B Ward
BACKGROUND: Poly-ureaurethane has been previously described for the management of dry, brittle, and in general, dystrophic nails. The polymer yields a waterproof, breathable barrier to protect the nail plate and prevent further damage to the nail, while regulating transonychial water loss (TOWL). Because nail dystrophy and dessication are contributing factors to onychomycosis, a barrier that protects the nail but also allows a topical antifungal to permeate its shield is potentially an advantageous combination...
September 1, 2016: Journal of Drugs in Dermatology: JDD
K Diongue, M A Diallo, M Ndiaye, A S Badiane, M C Seck, A Diop, Y D Ndiaye, D Ndiaye
INTRODUCTION: Superficial fungal infections, particularly of the skin, scalp and nails are very common and have been reported worldwide. The most common causative agents of these mycoses are dermatophytes, yeasts and molds. However, these agents vary with time and depend on many factors including the geography. The objective of this study was to identify the causative agents of superficial mycoses diagnosed at the Le Dantec University Hospital in Dakar (Senegal). MATERIAL AND METHODS: The study concerned 1851 outpatients received in the parasitological and mycological laboratory of Le Dantec hospital during the period from January 2011 to December 2015...
August 31, 2016: Journal de Mycologie Médicale
Ilteris Oguz Topal, Sule Gungor, Ozgur Emek Kocaturk, Hatice Duman, Mustafa Durmuscan
BACKGROUND: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. It has been suggested that nail abnormalities should be apparent in vitiligo patients. OBJECTIVE: We sought to document the frequency and clinical presentation of nail abnormalities in vitiligo patients compared to healthy volunteers. We also examined the correlations between nail abnormalities and various clinical parameters...
July 2016: Anais Brasileiros de Dermatologia
Jorge Ocampo-Garza, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio, Carlos D'Apparecida Machado-Filho
A 58-year-old female patient with an 8-month history of changes in the color and the shape of the nail of her right thumb was seen at our clinic. Physical examination revealed transverse overcurvature of the nail and a distal yellowish onycholytic area. (Figure 1A, B and 2A) X-ray, ultrasound and MRI of the right thumb were performed which showed no alterations. Direct microscopic examination of 10% KOH preparation of the affected nail demonstrated hyaline septate hyphae with a positive culture for Trichophyton rubrum...
August 31, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"