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https://www.readbyqxmd.com/read/28920516/high-glucose-mediated-overexpression-of-icam-1-in-human-vaginal-epithelial-cells-increases-adhesion-of-candida-albicans
#1
Hiroshige Mikamo, Yuka Yamagishi, Hiroyuki Sugiyama, Hisato Sadakata, Shun Miyazaki, Takako Sano, Tsutomu Tomita
To investigate the involvement of ICAM-1 in the adhesion of Candida to the genitourinary epithelial cells in high glucose, we examined the adhesion of Candida albicans or Candida glabrata to human vaginal epithelial cells (VK2/E6E7) or human vulvovaginal epidermal cells (A431). These cells were cultured in 100, 500 or 3000 mg/dL glucose for three days and inoculated with Candida for 60 minutes. Followed by, adhering of Candida to the cells, which were counted. While the adhesion of Candida albicans to VK2/E6E7 significantly increased in the high glucose, A431 did not...
September 18, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28919147/pediatric-resident-training-in-prepubertal-vulvar-conditions
#2
Monica Rosen, Veronica I Alaniz, Emily K Kobernik, Stephanie Booms, Yolanda R Smith, Elisabeth H Quint
STUDY OBJECTIVE: To assess pediatric resident training in diagnosing and managing prepubertal gynecologic conditions. DESIGN: Voluntary 32-question survey emailed to participants. SETTING: Email contact through the American Academy of Pediatrics listserve. PARTICIPANTS: 7075 U.S. pediatrics and combined internal medicine-pediatric residents. INTERVENTIONS: Descriptive analysis including Chi-square tests was performed on survey results...
September 14, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28911197/contribution-of-tlr2-pathway-in-the-pathogenesis-of-vulvovaginal-candidiasis
#3
María Soledad Miró, Emilse Rodríguez, Cecilia Vigezzi, Paula Alejandra Icely, Luciana N García, Nahuel Painetti, Cristina A Maldonado, Fernando Oscar Riera, Juan Pablo Caeiro, Claudia Elena Sotomayor
Candida albicans is the prevalent etiological agent in acute vulvovaginal infection and the most severe chronic condition known as recurrent vulvovaginal candidiasis (VVC). A critical role of local innate immunity in defense and pathogenesis of vaginal infection by Candida is proposed. The fungal recognition by the innate immune receptor is an essential step for the induction of local responses including cytokines and antimicrobial peptides (AMPs) production for host protection. Using TLR2-deficient mice, we characterized the early innate immune response during VVC...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28904795/cervical-superficial-myofibroblastoma-case-report-and-review-of-the-literature
#4
Mohamed Abdelaziz, Noura Eziba, Suash Sharma, Daniel Kleven, Ayman Al-Hendy
Superficial myofibroblastoma of the lower female genital tract is a rare benign, recently recognized neoplasm that mostly affects the vulvovaginal area. Our report discusses a case of cervical superficial myofibroblastoma of the lower female genital tract in a 45-year-old patient who is presented with menometrorrhagia. On examination, she had multiple uterine fibroids and a circumscribed submucosal mass lesion involving the anterior lip of cervix. At hysterectomy, histopathological examination of the cervical mass revealed a relatively hypocellular tumor consisted of bland spindled and stellate cells...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28894392/fractional-co2-laser-treatment-for-vulvovaginal-atrophy-symptoms-and-vaginal-rejuvenation-in-perimenopausal-women
#5
César Arroyo
BACKGROUND: This study investigated a novel fractional carbon dioxide (CO2) laser for treatment of symptoms associated with vulvovaginal atrophy (VVA) in perimenopausal women. METHODS: The study included 21 perimenopausal women (mean age 45±7 years) treated three times by CO2 laser resurfacing and coagulation of the vaginal canal tissue and mucosal tissue of the introitus. Vaginal health index (VHI) scores were computed by the investigator at baseline and follow-ups...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28885410/distressing-sexual-function-at-midlife-unmet-needs-practical-diagnoses-and-available-treatments
#6
James A Simon, Vanessa A Lukas
Female sexual dysfunction (FSD) is characterized as chronic sexual symptoms that manifest with personal distress in the domains of desire, arousal, orgasm, and pain. Extensive epidemiologic evidence estimates that almost 50% of perimenopausal and postmenopausal women experience FSD. Screening for FSD is not readily conducted and patient-physician discussion of sexuality is limited by the lack of physician training on the topic and by the patient-held belief that sexual issues are not medical in nature. The purpose of this commentary is to provide clinicians with a framework to approach the discussion of FSD, to clinically identify FSD through patient symptoms and physical signs, and to manage FSD in perimenopausal and postmenopausal patients with the available U...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28876387/assessment-of-cow-and-farm-level-risk-factors-associated-with-ureaplasma-diversum-in-pasture-based-dairy-systems-a-field-study
#7
Josefa M Nascimento-Rocha, Benedito D DE Oliveira, Emannuel Arnhold, Regiani N G Pôrto, Svetlana F Lima, Maria Lucia Gambarini
Potential risk factors for Ureaplasma diversum in the vaginal mucus of 1,238 dairy cows were included in a multivariate logistic regression model, based on the cow level (i.e., granular vulvovaginitis [+GVV], yearly milk production [4500 kg or more], pregnancy, predominance of Bos taurus [+Bos Taurus], score of corporal condition [at least 2.5], concomitant positivity for Escherichia coli [+E.coli]), and farm level i.e., milking room hygiene (-Milking room), dunghill location, and replacement female). Ureaplasma diversum was present in 41...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28868834/recurrent-vulvovaginal-candidiasis-could-it-be-related-to-cell-mediated-immunity-defect-in-response-to-candida-antigen
#8
Zahra Talaei, Saba Sheikhbahaei, Vajihe Ostadi, Mazdak Ganjalikhani Hakemi, Mohsen Meidani, Elham Naghshineh, Majid Yaran, Alireza Emami Naeini, Roya Sherkat
Background: Recurrent vulvovaginal candidiasis (RVVC) is a common cause of morbidity affecting millions of women worldwide. Patients with RVVC are thought to have an underlying immunologic defect. This study has been established to evaluate cell-mediated immunity defect in response to candida antigen in RVVC cases. MATERIALS AND METHODS: Our cross-sectional study was performed in 3 groups of RVVC patients (cases), healthy individuals (control I) and known cases of chronic mucocutaneous candidiasis (CMC) (control II)...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28867602/a-phase-3-double-blind-placebo-controlled-study-of-the-effectiveness-and-safety-of-single-oral-doses-of-secnidazole-2-g-for-the-treatment-of-women-with-bacterial-vaginosis
#9
Jane R Schwebke, Franklin G Morgan, William Koltun, Paul Nyirjesy
BACKGROUND: A novel single oral dose granule formulation of secnidazole 2 g, a 5-nitroimidazole with a longer half-life (∼17 hours) than metronidazole (∼8 hours), is being developed to treat bacterial vaginosis (BV). OBJECTIVE: To evaluate the effectiveness and safety of single-dose secnidazole 2 g compared to placebo for the treatment of women with BV. STUDY DESIGN: 189 women with BV were randomized 2:1 to receive a single oral dose of secnidazole 2 g (N=125) or matched placebo (N=64) at 21 centers in the US...
August 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28866964/effects-of-soy-isoflavones-on-the-concentration-of-hyaluronic-acid-in-the-vagina-of-type-1-diabetic-rats
#10
A A F Carbonel, P D Azevedo Lima, J J Lim, F Teixeira Borges, G Rodrigues da Silva Sasso, L F Portugal Fuchs, R S Simões, E Chada Baracat, J M Soares, M J Simões
OBJECTIVE: To assess the effects of isoflavones and 17β-estradiol on the vaginal epithelium extracellular matrix and hyaluronic acid (HA) in the diabetic rat model. METHODS: Sixty adult, virgin, female rats underwent ovariectomy, then randomization into six groups of ten animals each: GI, sham ovariectomized control animals; GII, sham ovariectomized control diabetic animals; GIII, control ovariectomized rats receiving propylene glycol vehicle; GIV, control ovariectomized diabetic animals receiving propylene glycol vehicle; GV, diabetic ovariectomized animals treated with soy isoflavones (150 mg/kg by gavage); GVI, ovariectomized diabetic rats treated with estrogen (17β-estradiol, 10 mg/kg, subcutaneously)...
September 2, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28866727/long-term-reliability-of-fractioned-co2-laser-as-a-treatment-for-vulvovaginal-atrophy-vva-symptoms
#11
Annalisa Pieralli, Claudia Bianchi, Manuela Longinotti, Serena Corioni, Noemi Auzzi, Angelamaria Becorpi, Maria Grazia Fallani, Giuseppe Cariti, Felice Petraglia
PURPOSE: The aim of this study was to evaluate long-term effects of the fractional CO2 laser for the treatment of vulvovaginal atrophy (VVA) symptoms. METHODS: Women presenting with VVA symptoms and meeting inclusion criterion were enrolled to fractioned CO2 laser therapy. Patient's satisfaction was measured on five-point Likert scale at 4 weeks and 6, 12, 18, 24 months after treatment by interview and clinical examination for vaginal livability. RESULTS: 184 patients constituted the final study group: 128 women were spontaneous menopause and 56 were oncological menopause...
September 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28861766/in-vitro-probiotic-properties-of-lactobacillus-salivarius-mg242-isolated-from-human-vagina
#12
Chang-Ho Kang, Seul Hwa Han, YongGyeong Kim, Nam-Soo Paek, Jae-Seong So
Vulvovaginal candidiasis (VVC) is a very common infection worldwide that is mainly caused by Candida albicans. In a previous study, we showed that Lactobacillus salivarius MG242 has anti-Gardnerella vaginalis activity. In this study, we investigated the potential of using L. salivarius MG242 for biocontrol of C. albicans. In line with the results from a spot overlay assay, MG242 inhibited the growth of C. albicans by 99.99 ± 0.01% in co-culture, suggesting that L. salivarius MG242 has the potential to be developed into a probiotic formula to treat or prevent VVC...
August 31, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28858028/prevalence-of-sexual-symptoms-in-relation-to-menopause-in-women-in-asia-a-systematic-review
#13
Rakibul M Islam, Robin J Bell, Susan R Davis
OBJECTIVE: This systematic review of the literature was undertaken to investigate the prevalence of sexual symptoms in women in Asia in relation to their menopause status. METHODS: MEDLINE, EMBASE, PsycINFO, CINAHL, SCOPUS, and Google scholar were searched systematically for relevant population-based prevalence studies published between 1988 and 2016. The included studies were assessed for risk of bias using a risk-of-bias tool developed explicitly for the systematic review of prevalence studies...
August 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28858027/dehydroepiandrosterone-use-in-postmenopausal-women-an-androgenic-option-for-managing-sexual-pain-caused-by-vulvovaginal-atrophy
#14
Gloria Bachmann, Nancy Phillips
No abstract text is available yet for this article.
August 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28853624/prevention-of-recurrent-lower-urinary-tract-infections-in-postmenopausal-women-with-genitourinary-syndrome-outcome-after-6-months-of-treatment-with-ospemifene
#15
Michele Carlo Schiavi, Anna Di Pinto, Valentina Sciuga, Pierangelo Faiano, Chiara Di Tucci, Ottavia D'oria, Angela Martoccia, Giovanni Prata, Carlo Carraro, Rosa Ostuni, Marzio Angelo Zullo, Ludovico Muzii, Pierluigi Benedetti Panici
Aim of this study was to evaluate the efficacy of ospemifene in the prevention of recurrent lower urinary tract infections in postmenopausal women with vulvovaginal atrophy. The study have a retrospective design. Thirty-nine patients were enrolled. Patients underwent clinical examination and urine culture. The urinary symptoms and the quality of life were evaluated with UTISA score, PUF and SF-36 questionnaires before and after treatment. All 39 patients received ospemifene 60 mg one tablet/daily for 6 months...
August 30, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28844452/characterization-of-virulence-factors-of-vaginal-and-anal-isolates-of-candida-albicans-sequentially-obtained-from-patients-with-vulvovaginal-candidiasis-in-north-east-brazil
#16
M Araújo Paulo de Medeiros, A P Vieira de Melo, A M Maia de Sousa, W P Silva-Rocha, E Pipolo Milan, G Maranhão Chaves
In order to better understand the pathogenesis of VVC, focusing on the role of C. albicans virulence factors in triggering this infirmity; we evaluated four virulence factors of 62 clinical isolates of C. albicans sequentially obtained from the vagina and anus of patients with sporadic and recurrent VVC. Virulence factors were phenotypically evaluated in vitro, including: adhesion capacity to epithelial cells obtained from healthy individuals, morphogenesis in the presence of fetal bovine serum, biofilm formation in polystyrene microtiter plates and proteinase activity using bovine serum albumin...
August 24, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28843942/sexual-function-in-women-suffering-from-genitourinary-syndrome-of-menopause-treated-with-fractionated-co2-laser
#17
REVIEW
Stefano Salvatore, Eleni Pitsouni, Fabio Del Deo, Marta Parma, Stavros Athanasiou, Massimo Candiani
INTRODUCTION: Genitourinary syndrome of menopause (GSM) has a significant impact on the trophism of the genital and lower urinary tracts and can considerably impair sexual function. Fractional CO2 laser has a regenerative effect on vulvovaginal tissue trophism after menopause. AIM: To review the available literature on the effect of fractional CO2 laser on the sexual function of postmenopausal women affected by GSM. METHODS: A database search was carried out using the terms CO2laser, vaginal atrophy, sexual function, dyspareunia, and genitourinary syndrome of menopause and excluding studies using other types of laser or including breast cancer survivors with vulvovaginal atrophy...
August 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28836889/candida-vulvovaginitis-and-vulvodynia-the-mystery-continues
#18
Barbara D Reed
No abstract text is available yet for this article.
August 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28831255/stratum-corneum-lipid-liposome-encapsulated-panomycocin-preparation-characterization-and-the-determination-of-antimycotic-efficacy-against-candida-spp-isolated-from-patients-with-vulvovaginitis-in-an-in-vitro-human-vaginal-epithelium-tissue-model
#19
Fatih İzgü, Günce Bayram, Kübra Tosun, Demet İzgü
In this study, a liposomal lyophilized powder formulation of panomycocin was developed for therapeutic purposes against vulvovaginal candidiasis which affects 80% of women worldwide. Panomycocin is a potent antimycotic protein secreted by the yeast Wickerhamomyces anomalus NCYC 434. This study involved the preparation of panomycocin-loaded stratum corneum lipid liposomes (SCLLs), characterization of the SCLLs, and determination of antimycotic efficacy of the formulation against Candida albicans and Candida glabrata clinical vaginal isolates in a human vaginal epithelium tissue model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28826987/in-vitro-potency-and-fungicidal-activity-of-cd101-a-novel-echinocandin-against-recent-clinical-isolates-of-candida-spp
#20
Danielle Hall, Robert Bonifas, Lauretta Stapert, Mary Thwaites, Dean L Shinabarger, Chris M Pillar
Candida infections vary in severity and manifestation. Common infections include invasive bloodstream infections among hospitalized/immunocompromised patients and vulvovaginal candidiasis among women. Echinocandins and azoles are commonly utilized to treat Candida infections, although echinocandin use has been restricted to indications amenable to once-daily IV administration. CD101, a novel echinocandin with a long plasma half-life and enhanced stability, is in development for once-weekly IV administration for the treatment of candidemia and invasive candidiasis...
July 21, 2017: Diagnostic Microbiology and Infectious Disease
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