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https://www.readbyqxmd.com/read/29150252/resolution-of-extensive-vulvovaginal-condylomatosis-following-immunoglobulin-replacement-in-primary-immunodeficiency-disorders
#1
Rohan V Ameratunga
No abstract text is available yet for this article.
November 14, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29136186/clonal-spread-and-azole-resistant-mechanisms-of-non-susceptible-candida-albicans-isolates-from-vulvovaginal-candidiasis-patients-in-three-shanghai-maternity-hospitals
#2
YongQin Wu, Cui Li, ZhiHeng Wang, Jing Gao, ZhenHua Tang, HuiFen Chen, ChunMei Ying
In our multicenter study, 43 fluconazole non-susceptible and 45 fluconazole-susceptible isolates were collected from vulvovaginal candidiasis (VVC) patients from three Shanghai maternity hospitals to analyze their molecular epidemiological features and fluconazole resistant mechanisms. Cross-resistance to fluconazole, itraconazole and voriconazole was observed in 53.5% of the nonsusceptible isolates. Though we acquired 12 clonal complexes (CCs) of diploid sequence types (DSTs) in clinical isolates by a multilocus sequence typing method, fluconazole nonsusceptible isolates all belonged to CC69 with a predominant genotype of DST 79...
November 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29135629/the-use-of-pulsed-co2-lasers-for-the-treatment-of-vulvovaginal-atrophy-erratum
#3
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29129498/a-novel-double-layer-mucoadhesive-tablet-containing-probiotic-strain-for-vaginal-administration-design-development-and-technological-evaluation
#4
María Teresa Sánchez, María Adolfina Ruiz, Herminia Castán, María Encarnación Morales
Vulvovaginal candidosis caused by Candida spp. is the most prevalent vaginal infection in Europe and the second one in EE.UU, so it has become a major female concern. Probiotics bacteria have been proposed as an alternative treatment with the aim of avoiding the adverse effects associated with conventional therapies including antibiotics and other aggressive drugs for the vaginal mucosa and microbiota. The purpose of this work was to design and develop a novel vaginal tablet that contained Lactobacillus spp...
November 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29113672/vulvo-vaginal-reconstruction-after-radical-excision-for-treatment-of-vulvar-cancer-evaluation-of-feasibility-and-morbidity-of-different-surgical-techniques
#5
REVIEW
Violante Di Donato, Carlotta Bracchi, Emanuele Cigna, Lavinia Domenici, Angela Musella, Andrea Giannini, Francesca Lecce, Claudia Marchetti, Pierluigi Benedetti Panici
BACKGROUND: Vulvar cancer is a rare disease accounting for approximately 5% of female genital tract tumors worldwide. Currently surgery represents the mainstay alone or sometimes, in combination with chemo-radiotherapy, for locally advanced tumors and recurrent disease. However, significant physical and sexual impairment mostly due to anatomical distortion of external genitalia are a consequence of radical surgical treatment. Postoperative reconstruction after demolitive surgeries improves aesthetic and functional results, guarantees an adequate coverage of large tumors and assures safe surgical margin...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29110332/is-mbl-serum-concentration-a-reliable-predictor-for-recurrent-vulvovaginal-candidiasis
#6
Mona Ghazanfari, Mehraban Falahati, Azam Fattahi, Fatemeh Bazrafshan, Sanam Nami, Morteza Hosseinzadeh, Fariba Heydarikohan, Mohsen Ghelman, Majid Khoshmirsafa, Ali Farzanegan
BACKGROUND: Recurrent vulvovaginal candidiasis (RVVC) is acommon opportunistic, mucosal fungal infection, predominantly caused by the fungus Candida albicans.Mannose-binding lectin (MBL) is an acute-phase protein that plays a key role in the innate immunity defense against infectious disease. OBJECTIVES: The present study was conducted to evaluate the relationship between the MBL serum level and the relative expression of MBL mRNA in RVVC using real-time PCR for the first time...
November 6, 2017: Mycoses
https://www.readbyqxmd.com/read/29109176/candidalysin-drives-epithelial-signaling-neutrophil-recruitment-and-immunopathology-at-the-vaginal-mucosa
#7
Jonathan P Richardson, Hubertine M E Willems, David L Moyes, Saeed Shoaie, Katherine S Barker, Shir Lynn Tan, Glen E Palmer, Bernhard Hube, Julian R Naglik, Brian M Peters
Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans, is a disease of immunocompetent and otherwise healthy women. Despite its prevalence, the fungal factors responsible for initiating symptomatic infection remain poorly understood. One of the hallmarks of vaginal candidiasis is the robust recruitment of neutrophils to the site of infection, which seemingly do not clear the fungus, but rather exacerbate disease symptomatology. Candidalysin, a newly discovered peptide toxin secreted by C...
November 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29095746/development-of-the-adult-vulvar-lichen-sclerosus-severity-scale-a-delphi-consensus-exercise-for-item-generation
#8
Michal Sheinis, Amanda Selk
OBJECTIVE: To generate a list of items through international expert consensus consisting of both symptoms and clinical signs for inclusion in an adult vulvar lichen sclerosus severity scale. METHODS: This study was carried out as a three-stage Delphi consensus exercise. After an extensive literature review, any items used to determine disease severity in previous clinical trials were compiled into a survey. The Delphi participants were recruited from the International Society for the Study of Vulvovaginal Disease most of whom were gynecologists and in practice for more than 20 years...
November 1, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29081774/immunobiological-activity-of-synthetically-prepared-immunodominant-galactomannosides-structurally-mimicking-aspergillus-galactomannan
#9
Ema Paulovičová, Lucia Paulovičová, Martin Hrubiško, Vadim B Krylov, Dmitry A Argunov, Nikolay E Nifantiev
The study is oriented at the in vitro evaluation of the immunobiological activity and efficacy of synthetically prepared isomeric pentasaccharides representing fragments of Aspergillus fumigatus cell-wall galactomannan and containing β-(1→5)-linked tetragalactofuranoside chain attached to O-6 (GM-1) or O-3 (GM-2) of a spacer-armed mannopyranoside residue. These compounds were studied as biotinylated conjugates which both demonstrated immunomodulatory activities on the RAW 264.7 cell line murine macrophages as in vitro innate immunity cell model...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29064335/overall-safety-of-ospemifene-in-postmenopausal-women-from-placebo-controlled-phase-2-and-3-trials
#10
James A Simon, Corrado Altomare, Susannah Cort, Wei Jiang, JoAnn V Pinkerton
OBJECTIVE: To evaluate the safety of daily oral ospemifene 60 mg, estrogen agonist/antagonist, used to treat moderate-to-severe dyspareunia due to postmenopausal vulvovaginal atrophy, which is part of genitourinary syndrome of menopause. METHODS: Post hoc analysis of safety data (treatment-emergent adverse events [TEAEs]) pooled from six phase 2 and 3 randomized, double-blind, multicenter placebo-controlled studies, evaluating the effects of ospemifene 60 mg on the breast, cardiovascular system, and bone in postmenopausal women...
October 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29062309/ph-dependant-antifungal-activity-of-valproic-acid-against-the-human-fungal-pathogen-candida-albicans
#11
Julien Chaillot, Faiza Tebbji, Carlos García, Hugo Wurtele, René Pelletier, Adnane Sellam
Current antifungal drugs suffer from limitations including toxicity, the emergence of resistance and decreased efficacy at low pH that are typical of human vaginal surfaces. Here, we have shown that the antipsychotic drug valproic acid (VPA) exhibited a strong antifungal activity against both sensitive and resistant Candida albicans in pH condition similar to that encountered in vagina. VPA exerted a strong anti-biofilm activity and attenuated damage of vaginal epithelial cells caused by C. albicans. We also showed that VPA synergizes with the allylamine antifungal, Terbinafine...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29057583/a-medical-device-containing-purified-bovine-colostrum-monurelle-biogel-in-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-retrospective-analysis-of-urinary-symptoms-sexual-function-and-quality-of-life
#12
M C Schiavi, C Di Tucci, V Colagiovanni, P Faiano, A Giannini, O D'Oria, G Prata, G Perniola, M Monti, M A Zullo, L Muzii, P Benedetti Panici
OBJECTIVE: This study assessed the effectiveness and safety of a medical device containing purified bovine colostrum (Monurelle Biogel; Zambon, Bresso, Italy) in improving vulvovaginal atrophy (VVA), sexual function, urinary symptoms, and quality of life (QoL) in postmenopausal women. METHODS: In all, 172 postmenopausal women with VVA were included in the study. All women were treated with vaginal Monurelle Biogel daily for 12 weeks. Patients underwent clinical examinations, completed a 3-day voiding diary, and had VVA graded using the Vaginal Health Index (VHI) at baseline and 12 weeks...
October 23, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29050446/management-of-mycoses-in-daily-practice
#13
Lorenzo Drago, Giuseppe Micali, Manuela Papini, Bianca M Piraccini, Stefano Veraldi
The guideline recommendations, albeit founded on thorough reviews of clinically relevant literature data, are often not immediately adaptable to everyday life. Considering the marked heterogeneity of superficial mycoses, each of them requires specific management in a real life context; in all cases diagnostic confirmation is required with microscopic and culture examination. In tinea capitis oral therapy is necessary (minimum six weeks) and should be continued until clinical and, above all, mycological healing...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29044352/-sulphurous-vaginal-douching-and-vulvovaginal-atrophy
#14
M Costantino, V Conti, M B Marongiu, G Napolano, A Filippelli
OBJECTIVE: During climacteric the reduction or interruption of estrogenic stimulus determines a gradual atrophy of the tissues of the urogenital tract.Vulvovaginal atrophy can be cause of dryness, itch, burning, and dyspareunia. Vulvovaginal atrophy is associated also with depression. Hence the importance of an appropriate treatment of the vulvovaginal atrophy. Between therapeutic options we can add, particularly for women who suffer only from vaginal symptoms, the spa therapy that uses mineral waters with benefic effects on vaginal tissue wellness and health...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29040373/nonsurgical-vulvovaginal-rejuvenation-with-radiofrequency-and-laser-devices-a-literature-review-and-comprehensive-update-for-aesthetic-surgeons
#15
Ali A Qureshi, Marissa M Tenenbaum, Terence M Myckatyn
Nonsurgical vulvovaginal rejuvenation (NVR) is growing in popularity as a treatment for restoration of youthful female genitalia. Numerous radiofrequency (RF) and laser devices have entered the market claiming improvement in vaginal laxity and genitourinary syndrome of menopause. There is a paucity of evidence existing concerning the effectiveness of these devices for both pre- and postmenopausal women with laxity and/or atrophy at the histologic and clinical level. Therefore, the goal of this review is to scrutinize the peer-reviewed data on NVR with RF and laser devices, identify gaps in existing literature, and propose opportunities for further investigation...
September 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29033921/influence-of-oral-and-gut-microbiota-in-the-health-of-menopausal-women
#16
REVIEW
Angélica T Vieira, Paula M Castelo, Daniel A Ribeiro, Caroline M Ferreira
Sex differences in gut microbiota are acknowledged, and evidence suggests that gut microbiota may have a role in higher incidence and/or severity of autoimmune diseases in females. Additionally, it has been suggested that oral, vaginal, and gut microbiota composition can be regulated by estrogen levels. The association of vaginal microbiota with vulvovaginal atrophy at menopause is well described in the literature. However, the relevance of oral and gut microbiota modulation in the immune system during estrogen deficiency and its effect on inflammatory diseases is not well explored...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28987021/computer-aided-diagnosis-software-for-vulvovaginal-candidiasis-detection-from-pap-smear-images
#17
Mohammadreza Momenzadeh, Alireza Vard, Ardeshir Talebi, Alireza Mehri Dehnavi, Hossein Rabbani
Vulvovaginal candidiasis (VVC) is a common gynecologic infection and it occurs when there is overgrowth of the yeast called Candida. VVC diagnosis is usually done by observing a Pap smear sample under a microscope and searching for the conidium and mycelium components of Candida. This manual method is time consuming, subjective and tedious. Any diagnosis tools that detect VVC, semi- or full-automatically, can be very helpful to pathologists. This article presents a computer aided diagnosis (CAD) software to improve human diagnosis of VVC from Pap smear samples...
October 7, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28986195/surface-modified-mucoadhesive-microgels-as-a-controlled-release-system-for-miconazole-nitrate-to-improve-localized-treatment-of-vulvovaginal-candidiasis
#18
Franklin C Kenechukwu, Anthony A Attama, Emmanuel C Ibezim, Petra O Nnamani, Chukwuebuka E Umeyor, Emmanuel M Uronnachi, Thaddeus H Gugu, Mumuni A Momoh, Kenneth C Ofokansi, Paul A Akpa
The use of conventional vaginal formulations of miconazole nitrate (MN) in the treatment of deep-seated VVC (vulvovaginal candidiasis) is limited by poor penetration capacity and low solubility of MN, short residence time and irritation at the application site. Surface-modified mucoadhesive microgels were developed to minimize local irritation, enhance penetration capacity and solubility and prolong localized vaginal delivery of MN for effective treatment of deep-seated VVC. Solid lipid microparticles (SLMs) were prepared from matrices consisting of hydrogenated palm oil (Softisan® 154, SF) and super-refined sunseed oil (SO) with or without polyethylene glycol (PEG)-4000, characterized for physicochemical performance and used to prepare mucoadhesive microgels (MMs) encapsulating MN, employing Polycarbophil as bioadhesive polymer...
October 4, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28959792/overexpression-of-mdr-1-and-cdr-2-genes-in-fluconazole-resistance-of-candida-albicans-isolated-from-patients-with-vulvovaginal-candidiasis
#19
K Khosravi Rad, M Falahati, M Roudbary, S Farahyar, S Nami
BACKGROUND AND PURPOSE: Candida albicans (C. albicans) is an opportunistic fungus that can colonize women's mucosal epithelial cell surfaces, causing vulvovaginitis in specific circumstances. The major genes contributing to drug resistance in C. albicans are the candida drug resistance (CDR) and multi drug resistance (MDR) genes. The purpose of this study was to evaluate the CDR-2 and MDR-1 gene expression patterns in C. albicans strains isolated from patients with recurrent vulvovaginal candidiasis...
December 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28956066/erratum-to-long-term-reliability-of-fractioned-co2-laser-as-a-treatment-for-vulvovaginal-atrophy-vva-symptoms
#20
Annalisa Pieralli, Claudia Bianchi, Manuela Longinotti, Serena Corioni, Noemi Auzzi, Angelamaria Becorpi, Maria Grazia Fallani, Giuseppe Cariti, Felice Petraglia
In original publication, the Fig. 1 was incorrect. The correct figure has been given below.
September 27, 2017: Archives of Gynecology and Obstetrics
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