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Celiac disease and diabetes mellitus

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https://www.readbyqxmd.com/read/27906802/anti-tissue-transglutaminase-normalization-post-diagnosis-in-children-with-celiac-disease
#1
Daniela Migliarese Isaac, Seema Rajani, Maryna Yaskina, Hien Q Huynh, Justine M Turner
OBJECTIVES: Limited pediatric data exist examining the trend and predictors of anti-tissue transglutaminase (atTG) normalization over time in children with celiac disease (CD). We aimed to evaluate time to normalization of atTG in children after CD diagnosis, and to assess for independent predictors impacting this duration. METHODS: A retrospective chart review was completed in pediatric CD patients diagnosed from 2007 to 2014 at the Stollery Children's Hospital Celiac Clinic (Edmonton, Alberta)...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27906796/cardiovascular-risk-factors-in-adolescents-with-celiac-disease-a-cross-sectional-population-based-study
#2
Amit Assa, Yael Frenkel-Nir, Dorit Tzur, Lior H Katz, Raanan Shamir
BACKGROUND: Recent data have shown that adults with celiac disease (CD) may have a higher prevalence of risk factors for cardiovascular disease (CVD) compared with the general population. Thus, we aimed to investigate the association of CD with CVD risk factors at late adolescence in a cross-sectional population based study. METHODS: A total of 2,001,353 Jewish Israeli adolescents who underwent a general health examination at median age of 17.1y from 1988 to 2015 were included...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27894748/ccr5-%C3%AE-32-gene-polymorphism-is-related-to-celiac-disease-and-autoimmune-thyroiditis-coincidence-in-patients-with-type-1-diabetes
#3
Bartosz Słomiński, Urszula Ławrynowicz, Jolanta Myśliwska, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Małgorzata Myśliwiec, Agnieszka Brandt
AIM: The aim of the study was to assess the relationship between CCR5-Δ32 polymorphism and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (T1D) in children. METHODS: 420 children with T1D aged 15.5±3.0years and 350 healthy controls were studied. Characterization of CCR5-Δ32 genotypes (rs333) was analyzed by polymerase chain reaction (PCR). RESULTS: The allele frequency was significantly different in diabetic children as compared to the healthy controls (p<0...
November 3, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27727675/prevalence-and-clinical-profile-of-celiac-disease-in-patients-with-type-1-diabetes-mellitus
#4
Ranjit Singh, Manish Gutch, Madukar Mittal, Sukriti Kumar, Syed Mohd Razi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27665287/palivizumab-exposure-and-the-risk-of-autoimmune-disease-a-cross-national-cohort-study
#5
Ann Haerskjold, Marie Linder, Lonny Henriksen, Simon Francis Thomsen, Helle Kieler, Henrik Ravn, Lone Graff Stensballe
BACKGROUND: Treatment with biologic pharmaceuticals may be associated with an increased risk of immune-mediated disease. Palivizumab is a humanized monoclonal antibody designed to provide passive immunity against respiratory syncytial virus infection. Palivizumab is primarily used in preterm children known to be immunologically immature. The long-term effect of palivizumab in terms of autoimmune diseases has not yet been investigated. AIM: Our objective was to investigate whether exposure to palivizumab was associated with the development of autoimmune diseases in children...
December 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27543737/frequency-of-hla-dqb1-0201-02-and-dqb1-0302-alleles-and-tissue-transglutaminase-antibody-seropositivity-in-children-with-type-1-diabetes-mellitus
#6
Thanita Thammarakcharoen, Nattiya Hirankarn, Taninee Sahakitrungruang, Thanunrat Thongmee, Pavinee Kuptawintu, Sriprapai Kanoonthong, Voranush Chongsrisawat
BACKGROUND: Patients with type 1 diabetes mellitus (T1DM) have an increased risk for celiac disease (CD). Both diseases have a common genetic susceptibility locus in the human leukocyte antigen (HLA) class II alleles. Testing for tissue transglutaminase antibodies (anti-tTG) is highly accurate for CD diagnosis. OBJECTIVE: To determine the frequency of HLA-DQB1*0201/02and DQB1*0302 alleles and anti-tTG seropositivity in children with T1DM. METHODS: Forty-six children with T1DM (male:female=24:22; mean age 12±3...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27530409/gastrointestinal-comorbidities-in-patients-with-psoriatic-arthritis
#7
Ariel Zohar, Arnon Dov Cohen, Haim Bitterman, Ilan Feldhamer, Sari Greenberg-Dotan, Idit Lavi, Doron Comanesther, Erez Batat, Devy Zisman
Comorbidities associated with psoriatic arthritis (PsA) include cardiovascular diseases, diabetes mellitus, and obesity. This study evaluated the association between PsA and common gastrointestinal (GI) diseases. A retrospective study was performed in Israel's largest health care provider database between 2002 and 2013. 3161 PsA patients were matched for age and sex with 31610 randomly selected patients. We searched these patients' records for the presence of peptic ulcer disease (PUD), reflux esophagitis, Crohn's disease, ulcerative colitis, irritable bowel syndrome (IBS) and celiac disease...
November 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27525273/effect-of-associated-autoimmune-diseases-on-type-1-diabetes-mellitus-incidence-and-metabolic-control-in-children-and-adolescents
#8
REVIEW
Aleksandra Krzewska, Iwona Ben-Skowronek
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases developing in childhood. The incidence of the disease in children increases for unknown reasons at a rate from 3 to 5% every year worldwide. The background of T1DM is associated with the autoimmune process of pancreatic beta cell destruction, which leads to absolute insulin deficiency and organ damage. Complex interactions between environmental and genetic factors contribute to the development of T1DM in genetically predisposed patients...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27492679/celiac-disease-presenting-as-profound-diarrhea-and-weight-loss-a-celiac-crisis
#9
Vadim Bul, Brett Sleesman, Brian Boulay
BACKGROUND Celiac disease is a hypersensitivity enteropathy that can have various presentations in adults. Rarely, patients can present with severe lab abnormalities, dehydration and weight loss caused by celiac disease - a celiac crisis. CASE REPORT A 46-year-old male with a past medical history significant for diabetes mellitus, type 2 (DM2) and recently treated Bell's Palsy presented to the emergency room complaining of weakness, diarrhea and lightheadedness. On presentation, the patient had a systolic blood pressure (SBP) of 60 mm Hg and a lactic acidosis with pH of 7...
August 5, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27487045/anti-zinc-transporter-protein-8-antibody-testing-is-not-informative-in-routine-prediabetes-screening-in-young-patients-with-autoimmune-thyroiditis-and-celiac-disease
#10
Daniela Larizza, Mara De Amici, Catherine Klersy, Michela Albanesi, Riccardo Albertini, Carla Badulli, Cristina Torre, Valeria Calcaterra
BACKGROUND/AIMS: Patients with type 1 diabetes mellitus (T1DM), autoimmune thyroiditis (ATD), and celiac disease (CD) are at increased risk for developing other autoimmune diseases. We evaluated zinc transporter 8 (ZnT8) prevalence in patients with ATD and/or CD in order to define the usefulness of ZnT8 autoantibodies for prediabetes screening. METHODS: Eighty-one young patients with ATD and/or CD were included in the study; 32 subjects with clinical onset of T1DM were enrolled as a control group...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27442363/in-children-with-autoimmune-thyroid-diseases-the-association-with-down-syndrome-can-modify-the-clustering-of-extra-thyroidal-autoimmune-disorders
#11
Tommaso Aversa, Mariella Valenzise, Andrea Corrias, Mariacarolina Salerno, Lorenzo Iughetti, Daniele Tessaris, Donatella Capalbo, Barbara Predieri, Filippo De Luca, Malgorzata Wasniewska
BACKGROUND: It is known that the association with Down syndrome (DS) can affect the phenotypic expression of autoimmune thyroid diseases (AITDs), whilst is unknown whether the clustering of extra-thyroidal autoimmune diseases (ETADs) may also be atypical in DS children. METHODS: The aim of this study was to investigate the clustering of ETADs in 832 children with AITDs divided in two groups with or without DS (A and B, respectively) and in four subgroups of patients aged either <6 or ≥6 years...
September 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27429649/overweight-among-children-and-adolescent-with-type-i-diabetes-mellitus-prevalence-and-associated-factors
#12
Verônica Medeiros da Costa, Patricia de Carvalho Padilha, Géssica Castor Fontes de Lima, Aline Alves Ferreira, Jorge Luiz Luescher, Luciana Porto, Wilza Arantes Ferreira Peres
OBJECTIVES: Describe the overweight frequency (overweight and obesity) and identify the factors associated with this in children and adolescents with type 1 diabetes mellitus (T1DM) treated at a University Children's Hospital in Rio de Janeiro. METHODS: This is an analytical cross-sectional study, which included patients diagnosed with T1DM who had complete anthropometric data (weight and height) and excluded those using drugs with effect on weight gain, genetic syndromes, celiac disease, hypothyroidism, renal failure and other chronic diseases, and pregnant women...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27423071/evaluation-of-therapeutics-management-patterns-and-glycemic-control-of-pediatric-type-1-diabetes-mellitus-patients-in-turkey-a-nationwide-cross-sectional-study
#13
Şükrü Hatun, Hüseyin Demirbilek, Şükran Darcan, Ayşegül Yüksel, Cigdem Binay, Damla Gökşen Şimşek, Cengiz Kara, Ergun Çetinkaya, Tolga Ünüvar, Ahmet Uçaktürk, Filiz Tütüncüler, Yaşar Cesur, Ruveyde Bundak, Halil Sağlam, Enver Şimşek, Abdullah Bereket
AIMS: To evaluate the management strategies, glycemic control and complications of pediatric type 1 diabetes mellitus (T1DM) patients in Turkey. METHODS: Study included 498 patients with T1DM between the ages 1-18. Data provided from patients' hospital files were recorded on standard case report forms by applicant clinicians within the 3months of data collection period between October 2012 and July 2013. RESULTS: Mean age of patients was 11...
September 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27312169/celiac-disease-with-evans-syndrome-and-isolated-immune-thrombocytopenia-in-monozygotic-twins-a-rare-association
#14
Jelena Roganovic
Celiac disease is a multisystem immune-mediated disorder caused by exposure to dietary gluten in genetically predisposed individuals. The clinical presentation is characterized by a multitude and diversity of symptoms and complications. The coexistence of celiac disease with other autoimmune disorders has been established, most frequently with type 1 diabetes mellitus and autoimmune thyroiditis. The association of celiac disease with immune-mediated hematologic conditions has been rarely reported. This case study describes a pair of identical twin sisters with celiac disease associated with Evans syndrome in one sibling, and with isolated immune thrombocytopenia in the other...
April 2016: Seminars in Hematology
https://www.readbyqxmd.com/read/27241973/update-on-bone-health-in-pediatric-chronic-disease
#15
REVIEW
Kristen M Williams
Children and adolescents with chronic disease are predisposed to impaired bone health. Pediatric illness, including type 1 diabetes mellitus, celiac disease, and cystic fibrosis, have significant risk of low bone mineralization and fracture due to underlying inflammation, malabsorption, lack of physical activity, and delayed puberty. Dual-energy x-ray absorptiometry is the primary imaging method to assess bone health in this population. The purpose of this review is to update readers about the assessment and management of bone health in children with common pediatric chronic illnesses and review recent advances in the prevention and treatment of impaired bone health...
June 2016: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/27186558/association-of-type-1-diabetes-mellitus-and-autoimmune-disorders-in-brazilian-children-and-adolescents
#16
Crésio Alves, Larissa Siqueira Santos, Maria Betânia P Toralles
CONTEXT: Type 1 diabetes mellitus (T1DM) is caused by an immune-mediated destruction of pancreatic beta cells. Other autoimmune diseases can be observed in association with T1DM. The screening for celiac disease (CD) and Hashimoto's thyroiditis is necessary due to the increased prevalence of these pathologies in T1DM patients. AIMS: This study aimed to investigate the prevalence of autoimmune markers for pancreatitis, thyroiditis, and CD in racially admixtured children and adolescents with T1DM...
May 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27052281/pattern-of-thyroid-celiac-and-anti-cyclic-citrullinated-peptide-autoantibodies-coexistence-with-type-1-diabetes-mellitus-in-patients-from-southwestern-saudi-arabia
#17
Ahmed M Al-Hakami
OBJECTIVES: To investigate the seroprevalence of coexisting autoantibodies among type 1 diabetes mellitus (T1DM) patients, and to look for possible correlations with age at diagnosis, diabetes duration, and glycemic control. METHODS: This is a cross-sectional study conducted at Aseer Central Hospital, Abha, Kingdom of Saudi Arabia from March 2013 to June 2014. A total of 202 T1DM patients were screened for serum anti-thyroglobulin (TG), anti-thyroid peroxidase (TPO), anti-tissue transglutaminase (aTTG), anti-endomysial (EMA), and anti-cyclic citrullinated peptide (anti-CCP) antibodies along with glycated hemoglobin, and biometric data...
April 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27052236/-exocrine-pancreatic-insufficiency-and-diabetes-mellitus
#18
Raimund Weitgasser, Heidemarie Abrahamian, Martin Clodi, Sandra Zlamal-Fortunat, Heinz F Hammer
Exocrine pancreatic insufficiency (EPI) in diabetic patients is frequent. Studies based on fecal elastase-1 measurement give prevalence rates of 10‒30 % of severe and 22‒56 % of moderate EPI in type 1 and rates of 5‒46 % in type 2 diabetic patients. Nevertheless, not all patients report typical symptoms like diarrhea, steatorrhea and weight loss. For noninvasive testing the determination of fecal elastase-1 has the highest sensitivity and specificity. This test should be performed at least in all symptomatic patients...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27021409/celiac-disease-and-risk-of-autoimmune-disorders-a-population-based-matched-birth-cohort-study
#19
Cristina Canova, Gisella Pitter, Jonas F Ludvigsson, Pierantonio Romor, Loris Zanier, Renzo Zanotti, Lorenzo Simonato
OBJECTIVES: To estimate the relative risk of developing type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease in children with celiac disease (CD). STUDY DESIGN: A matched cohort design with linkage of administrative data was adopted. A total of 1215 cases of CD and 6075 references matched by sex and year of birth born in Friuli Venezia Giulia Region (Italy) between 1989 and 2011 were included. Cox regression models were used to estimate hazard ratios (HRs) for autoimmune diseases in patients with CD compared with references, stratified by sex and age at diagnosis...
July 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27008690/organ-specific-autoimmunity-in-relation-to-clinical-characteristics-in-children-with-long-lasting-type-1-diabetes
#20
Barbara Głowińska-Olszewska, Justyna Michalak, Włodzimierz Łuczyński, Maria Del Pilar Larosa, Shu Chen, Jadwiga Furmaniak, Bernard Rees Smith, Artur Bossowski
BACKGROUND: The aim of this study was to assess the prevalence of diabetes and other organ-specific autoantibodies (Ab) associated with various autoimmune conditions, in Polish children with type 1 diabetes mellitus (T1DM). METHODS: In this study 114 patients, aged 13.4 years, with mean diabetes duration 5.2 years were included. Ab to islet cell antigens: glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA-2), zinc transporter 8 (ZnT8), together with thyroid peroxidase Ab (TPO Ab), thyroglobulin Ab (Tg Ab), tissue transglutaminase Ab (tTG Ab) and 21-hydroxylase Ab (21-OH Ab) were measured...
June 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
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