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Celiac disease in children

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https://www.readbyqxmd.com/read/28530848/splanchnic-thoracoabdominal-and-cerebral-blood-flow-volumes-in-healthy-children-and-young-adults-in-fasting-and-postprandial-states-determining-reference-ranges-by-using-phase-contrast-mr-imaging
#1
Prakash Muthusami, Shi-Joon Yoo, Rajiv Chaturvedi, Navjot Gill, Jonathan Windram, Daryl Schantz, Milan Prsa, Pablo Caro-Dominguez, Mike Seed, Lars Grosse-Wortmann, Simon C Ling, Govind B Chavhan
Purpose To estimate reference ranges for blood flow volume (BFV) in major splanchnic, thoracoabdominal, and neck vessels by using phase-contrast magnetic resonance (MR) imaging in children and young adults in fasting and postprandial states. Materials and Methods In this institutional research ethics board-approved prospective study, healthy volunteers underwent phase-contrast MR imaging in a fasting state and again after a standardized meal. BFV values were reported as medians and ranges, and postmeal to premeal BFV ratios were calculated...
May 22, 2017: Radiology
https://www.readbyqxmd.com/read/28514313/clinical-and-biological-correlations-in-celiac-disease-in-children-the-prospective-single-experience-of-a-romanian-tertiary-center-a-case-control-study-strobe-compliant-study
#2
Cristina Oana Marginean, Lorena Elena Meliţ, Roxana-Cristina Mareş, Maria Oana Mărginean, Septimiu Voidăzan, Minodora Dobreanu
Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also to evaluate the clinical and laboratory characteristics of patients admitted with the suspicion of celiac disease (CD)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28514243/celiac-disease-symptom-resolution-effectiveness-of-the-gluten-free-diet
#3
Naire Sansotta, Stefano Guandalini, Karine Amirikian, Hilary Jericho
OBJECTIVE: To evaluate the efficacy of the gluten free diet (GFD) on gastrointestinal and extra-intestinal symptom resolution and identify predictors for persistence of symptoms in all celiac patients at the University of Chicago. METHODS: We conducted a retrospective chart review from 2002 to 2015. Gastrointestinal (GI) symptoms included: abdominal pain, bloating, constipation, diarrhea, failure to thrive/weight loss, nausea, reflux and vomiting. Extra-intestinal (EI) symptoms included: abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis, alopecia, fatigue, headache, anemia, stomatitis, myalgia, psychiatric disorders, rashes, seizures, neuropathy, short stature, delayed puberty, osteoporosis, and infertility...
May 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28507424/migraine-celiac-disease-and-intestinal-microbiota
#4
COMMENT
Hakim Rahmoune, Nada Boutrid
Investigators from four European tertiary care hospitals (in Paris, France; Milan, Udine and Perugia, Italy) performed a case-control study of children and adolescents aged 6 to 17 years diagnosed with primary headaches in the emergency department by a pediatric neurologist using the validated ICHD-3 criteria.
February 2017: Pediatric neurology briefs
https://www.readbyqxmd.com/read/28499697/assessment-of-dietary-compliance-in-celiac-children-using-a-standardized-dietary-interview
#5
Margaretha M S Wessels, Marije Te Lintelo, Sabine L Vriezinga, Hein Putter, Erica G Hopman, M Luisa Mearin
BACKGROUND & AIMS: Compliance to a gluten free diet (GFD) in celiac disease (CD) is ideally assessed by dietary interviews, albeit time-consuming. Short dietary questionnaires have been developed for adults but not for children. Primary aim was to compare GFD compliance in celiac children, measured by a short dietary questionnaire against a dietary interview. Secondary aims were correlation between both questionnaires and celiac antibodies and identifying variables predicting noncompliance...
April 17, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28496327/anorexia-nervosa-of-the-restrictive-type-and-celiac-disease-in-adolescence
#6
Renata Nacinovich, Lucio Tremolizzo, Fabiola Corbetta, Elisa Conti, Francesca Neri, Monica Bomba
BACKGROUND: Anorexia nervosa (AN) is usually present in adolescence with symptoms partially overlapping celiac disease (CD), but the relationship between these two conditions has received little attention in the literature. The aim of this work was to explore this relationship, considering if CD could be associated with specific baseline AN-related clinical features. METHODS: In this retrospective study, 82 adolescent female out- and inpatients with AN of the restrictive type (ANr), according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria, were recruited...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28489675/no-need-for-routine-endoscopy-in-children-with-celiac-disease-on-a-gluten-free-diet
#7
Sibylle Koletzko, Renata Auricchio, Jernej Dolinsek, Peter Gillett, Ilma Korponay-Szabo, Kalle Kurppa, Luisa Mearin, Markkku Mäki, Alina Popp, Carmen Ribes, Raanan Shamir, Ketil Stordal, Riccardo Troncone, Katharina Werkstetter, Margreet Wessels, Klaus-Peter Zimmer, Steffen Husby
No abstract text is available yet for this article.
May 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28462126/reactive-oxygen-species-and-antioxidant-defense-in-human-gastrointestinal-diseases
#8
REVIEW
Peter Patlevič, Janka Vašková, Pavol Švorc, Ladislav Vaško, Pavol Švorc
Crohn's disease and ulcerative colitis, known together as inflammatory bowel diseases (IBDs), and celiac disease are the most common disorders affecting not only adults but also children. Both IBDs and celiac disease are associated with oxidative stress, which may play a significant role in their etiologies. Reactive oxygen species (ROS) such as superoxide radicals (O2•(-)), hydroxyl radicals (•OH), hydrogen peroxide (H2O2), and singlet oxygen ((1)O2) are responsible for cell death via oxidation of DNA, proteins, lipids, and almost any other cellular constituent...
December 2016: Integr Med Res
https://www.readbyqxmd.com/read/28461829/celiac-disease-phenotype-in-clinically-diagnosed-romanian-adults-and-children
#9
Balaban Vasile, Balaban Vasile, Popp Alina, Vasilescu Florina, Ene Adina, Jinga Mariana
BACKGROUND: Once considered a disease of childhood, celiac disease (CD) is now seen quite frequently in adults also, but with different and various clinical presentation. Little data is currently available about pediatric and adult CD features in Romanian patients. METHODS: 38 newly-diagnosed CD patients (17 adults and 21 children) were recruited for this study. The two groups (adult and pediatric) were compared regarding demographic, clinical, serologic and histological data...
June 2016: Mædica
https://www.readbyqxmd.com/read/28461188/validation-of-antibody-based-strategies-for-diagnosis-of-pediatric-celiac-disease-without-biopsy
#10
Johannes Wolf, David Petroff, Thomas Richter, Marcus Kh Auth, Holm H Uhlig, Martin W Laass, Peter Lauenstein, Andreas Krahl, Norman Händel, Jan de Laffolie, Almuthe C Hauer, Thomas Kehler, Gunter Flemming, Frank Schmidt, Astor Rodriques, Dirk Hasenclever, Thomas Mothes
BACKGROUND AND AIMS: A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, based largely on retrospective data, propose omitting biopsy analysis for patients with concentrations of immunoglobulin A against tissue transglutaminase (IgA-TTG) more than 10-fold the upper limit of normal (ULN) and if further criteria are met. A retrospective study concluded that measurements of IgA-TTG and total IgA, or IgA-TTG and IgG against deamidated gliadin (IgG-DGL) could identify patients with and without celiac disease...
April 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28456719/abnormalities-in-cd57-cytotoxic-t-cells-and-v%C3%AE-1-%C3%AE-%C3%AE-t-cells-in-subclinical-celiac-disease-in-childhood-are-affected-by-cytomegalovirus-the-generation-r-study
#11
M A E Jansen, D van den Heuvel, V W V Jaddoe, M C van Zelm, H A Moll
Celiac disease (CD) is a digestive and autoimmune disorder driven by an immune response to modified gluten peptides. Affected intestines show infiltrates of various T-cell and NK-cell subsets. It is currently unclear if individuals with subclinical CD have systemic abnormalities in immune cells. We here studied whether subclinical CD is associated with changes in blood CD57-expressing and Vδ1-expressing lymphocytes in children, and whether cytomegalovirus (CMV) infection modifies this association. Included were 1068 children from the Generation R Study...
April 26, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28452100/pediatric-psoriasis-should-we-be-concerned-with-comorbidities-a-cross-sectional-study
#12
A Kelati, H Baybay, A Najdi, S Zinoune, F Z Mernissi
BACKGROUND: Similarly to psoriasis in adult, Recent research has linked psoriasis to several comorbidities in children. Our objective was to describe comorbidities associated with pediatric psoriasis, to investigate their relationship with psoriasis characteristics and severity, and to perform a review of the literature. METHODS: A cross-sectional study was performed on a sample of Moroccan psoriatic children, during two years 2014 -2016. RESULTS: 64 psoriatic children had metabolic comorbidities in association with psoriasis, 20 children had non-metabolic comorbidities and 76 children didn't have any comorbidities...
April 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28448550/priority-target-conditions-for-algorithms-for-monitoring-children-s-growth-interdisciplinary-consensus
#13
Pauline Scherdel, Rachel Reynaud, Christine Pietrement, Jean-François Salaün, Marc Bellaïche, Michel Arnould, Bertrand Chevallier, Hugues Piloquet, Emmanuel Jobez, Jacques Cheymol, Emmanuelle Bichara, Barbara Heude, Martin Chalumeau
BACKGROUND: Growth monitoring of apparently healthy children aims at early detection of serious conditions through the use of both clinical expertise and algorithms that define abnormal growth. Optimization of growth monitoring requires standardization of the definition of abnormal growth, and the selection of the priority target conditions is a prerequisite of such standardization. OBJECTIVE: To obtain a consensus about the priority target conditions for algorithms monitoring children's growth...
2017: PloS One
https://www.readbyqxmd.com/read/28440012/image-defined-risk-factors-in-unresectable-neuroblastoma-siopen-study-on-incidence-chemotherapy-induced-variation-and-impact-on-surgical-outcomes
#14
Stefano Avanzini, Luca Pio, Giovanni Erminio, Claudio Granata, Keith Holmes, Marion Gambart, Piero Buffa, Victoria Castel, Dominique Valteau Couanet, Alberto Garaventa, Angela Pistorio, Giovanni Cecchetto, Giuseppe Martucciello, Girolamo Mattioli, Sabine Sarnacki
PURPOSE: To evaluate the impact of image-defined risk factor (IDRF) modification after chemotherapy on surgical outcomes, event-free survival (EFS), and overall survival (OS) among patients enrolled in the European Unresectable Neuroblastoma (EUNB) study. METHODS: IDRFs were assigned according to the corresponding surgical risk factors list reported in the database. Surgical outcomes, EFS, and OS were related to IDRF modification with chemotherapy. The predictive value of preoperative IDRF for surgical outcomes was analyzed...
April 25, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28431885/safety-of-adding-oats-to-a-gluten-free-diet-for-patients-with-celiac-disease-systematic-review-and-meta-analysis-of-clinical-and-observational-studies
#15
María Inés Pinto-Sánchez, Natalia Causada-Calo, Premysl Bercik, Alexander C Ford, Joseph A Murray, David Armstrong, Carol Semrad, Sonia S Kupfer, Armin Alaedini, Paul Moayyedi, Daniel A Leffler, Elena F Verdú, Peter Green
BACKGROUND & AIMS: Patients with celiac disease should maintain a gluten-free diet (GFD), excluding wheat, rye, and barley. Oats might increase the nutritional value of a GFD, but their including is controversial. We performed a systematic review and meta-analysis to evaluate the safety of oats as part of a GFD in patients with celiac disease. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE databases for clinical trials and observational studies of the effects of including oats in GFD of patients with celiac disease...
April 18, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28420279/responses-of-blood-mononucleated-cells-and-clinical-outcome-of-non-celiac-gluten-sensitive-pediatric-patients-to-various-cereal-sources-a-pilot-study
#16
Patrizia Alvisi, Luigia De Fazio, Maria Chiara Valerii, Elena Cavazza, Angela Salerno, Doriana Lacorte, Giovanni Dinelli, Enzo Spisni
Non-celiac gluten sensitivity (NCGS) is a clinical entity recently documented by the scientific community in pediatric patients. Nevertheless, its triggering mechanisms remain largely unsettled. We studied 11 children with NCGS who were diagnosed based on a clear-cut relationship between wheat consumption and development of symptoms, after excluding celiac disease (CD) and wheat allergy, matched with 18 children with active CD. Sixteen pediatric patients were also enrolled as controls. Cultured peripheral blood mononucleated cells (PBMCs) obtained from NCGS, CD and control patients were cultured in the presence of wheat proteins extracted from ancient and modern cultivars...
April 19, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28399059/rotavirus-vaccination-and-the-risk-of-celiac-disease-or-type-1-diabetes-in-finnish-children-at-early-life
#17
Vaarala Outi, Jokinen Jukka, Lahdenkari Mika, Leino Tuija
Rotavirus infection has been suggested as a trigger of type 1 diabetes (T1D) and celiac disease (CD) related autoimmunity. We carried out a nationwide population-based cohort study evaluating whether prevention of rotavirus infection with vaccination affects the risk of CD and T1D diagnosed during 2009-2014 in Finnish children by comparing vaccinated and unvaccinated children in a cohort born in 2009-2010. Nationwide rotavirus vaccination records were collected from health-care databases during 2009-2011 and validated for a sample of 495 children born 7/2009-12/2009...
April 10, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28378737/-all-russian-consensus-on-diagnosis-and-treatment-of-celiac-disease-in-children-and-adults
#18
A I Parfenov, S V Bykova, E A Sabel'nikova, I V Maev, A A Baranov, I G Bakulin, L M Krums, S V Bel'mer, T E Borovik, I N Zakharova, Yu A Dmitrieva, E A Roslavtseva, E A Kornienko, A I Khavkin, A S Potapov, M O Revnova, Yu G Mukhina, P L Shcherbakov, E D Fedorov, E A Belousova, I L Khalif, S G Khomeriki, D L Rotin, N G Vorob'eva, A V Pivnik, R B Gudkova, V V Chernin, N V Vokhmyanina, T V Pukhlikova, D A Degtyarev, I V Damulin, A M Mkrtumyan, G S Dzhulai, N K Tetruashvili, A Yu Baranovsky, L I Nazarenko, A G Kharitonov, I D Loranskaya, R G Saifutdinov, M A Livzan, D A Abramov, M F Osipenko, L V Oreshko, E I Tkachenko, S I Sitkin, L I Efremov
The paper presents the All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults, which has been elaborated by leading experts, such as gastroenterologists and pediatricians of Russia on the basis of the existing Russian and international guidelines. The consensus approved at the 42nd Annual Scientific Session of the Central Research Institute of Gastroenterology on Principles of Evidence-Based Medicine into Clinical Practice (March 2-3, 2016). The consensus is intended for practitioners engaged in the management and treatment of patients with celiac disease...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28359357/hmgb1-as-a-new-biomarker-of-celiac-disease-in-children-a%C3%A2-multicenter-study
#19
Sara Manti, Caterina Cuppari, Lucia Tardino, Giuseppe Parisi, Massimo Spina, Carmelo Salpietro, Salvatore Leonardi
OBJECTIVE: Despite the availability of specific sierology and point-of-care tests, the phenotypic heterogeneity and the symptoms fluctuation as well as the "open-window" existing among the late and silent forms cause often a delayed celiac disease (CD) diagnosis. Recently, it has been reported that high mobility group box 1 (HMGB1) mediates inflammation and gastrointestinal barrier failure. The aim of this study was to detect serum HMGB1 levels at CD diagnosis and to evaluate the relationship between serum HMGB1 levels and clinical and histologic phenotypes...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28350936/screening-for-celiac-disease-us-preventive-services-task-force-recommendation-statement
#20
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, Mark Ebell, John W Epling, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye, and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. Evidence Review: The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease...
March 28, 2017: JAMA: the Journal of the American Medical Association
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