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https://www.readbyqxmd.com/read/27895320/clinical-experience-with-pancreas-graft-rescue-from-severe-thrombus-after-simultaneous-pancreas-kidney-transplantation-by-early-detection-with-doppler-ultrasound-a-case-report
#1
Mitsunobu Takeda, Daisaku Yamada, Hidetoshi Eguchi, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Goto, Koichi Kawamoto, Yutaka Takeda, Masahiro Tanemura, Toshinori Ito, Masaki Mori, Yuichiro Doki
BACKGROUND Graft thrombosis is the main cause of early graft loss after transplantation. In Japan, pancreases available for transplantation are frequently from marginal donors due to diverse backgrounds in the population. However, marginal tissues increase the risk of early thrombosis in the graft. CASE REPORT Here, we describe a 41-year-old woman with type 1 diabetes mellitus who underwent a simultaneous pancreas-kidney transplantation. The pancreas was retrieved from a 34-year-old man who had experienced severe hemodynamic instability...
November 29, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27892930/an-optimized-protocol-for-purification-of-functional-islets-of-langerhans
#2
Youakim Saliba, Jules-Joel Bakhos, Tarek Itani, Nassim Farès
Islets of Langerhans and β-cell isolation constitute routinely used cell models for diabetic research, and refining islet isolation protocols and cell quality assessment is a high priority. Numerous protocols have been published describing isolate of islets, but often rigorous and systematic assessment of their integrity is lacking. Herein, we propose a new protocol for optimal generation of islets. Pancreases from mice and rats were excised and digested using a low-activity collagenase solution and islets were then purified by a series of sedimentations and a Percoll gradient...
November 28, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27882092/the-influence-of-exendin-4-intervention-on-obese-diabetic-mouse-blood-and-the-pancreatic-tissue-immune-microenvironment
#3
Jinshui He, Chaowei Lian, Yanling Fang, Jinzhi Wu, Huowang Zhou, Xiaoling Ye
The aim of the study was to determine the influence of exendin-4 intervention on non-obese diabetic (NOD) mouse blood and the pancreatic tissue immune microenvironment. A total of 40 clean NOD mice were used in the study and randomly divided into 4 groups (n=10/group). The first group was blank control group D with normal saline intervention, and with different doses of exendin, i.e.,-4 2, 4 and 8 µg/kg/day. The three remaining groups were: i) Low-dose group A; ii) medium-dose group B; and iii) high-dose group C...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27874968/professionalization-of-surgical-abdominal-organ-recovery-leading-to-an-increase-in-pancreatic-allografts-accepted-for-transplantation-in-the-netherlands-a-serial-analysis
#4
H D Lam, A F Schaapherder, W H Kopp, H Putter, A E Braat, A Baranski
Professional abdominal organ recovery with certification has been mandatory in the Netherlands since 2010. This study analyses the effects of certification (January 2010 - September 2015) on pancreas transplantation and compares it to an era before certification (February 2002 - May 2008) for surgical injuries and the number of pancreases transplanted. A total of 264 cases were analysed. Eighty-four recovered pancreases (31.8%) with surgically injuries were encountered. Forty six of those were surgically salvaged for transplantation, resulting in a total of 226 (85...
November 22, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27873446/the-first-two-years-of-activity-of-a-specialized-organ-procurement-centre-report-of-an-innovative-approach-to-improve-organ-donation
#5
Pierre Marsolais, Philippe Durand, Emmanuel Charbonney, Karim Serri, Anne-Marie Lagacé, Francis Bernard, Martin Albert
The number of patients requiring organ transplants continues to outgrow the number of organs donated each year. In an attempt to improve the organ donation process and increase the number of organs available, we created a specialized multidisciplinary team within a specialized Organ Procurement Centre (OPC) with dedicated intensive care unit beds and operating rooms. The OPC was staffed with ICU nurses, operating room nurses, organ donor management ICU physicians and multidisciplinary staff. All organ donors within a designated geographic area were transferred and managed within the OPC...
November 22, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27871680/clinical-significance-of-circumportal-pancreas-a-rare-congenital-anomaly-in-pancreatectomy
#6
Takao Ohtsuka, Yasuhisa Mori, Kousei Ishigami, Takaaki Fujimoto, Yoshihiro Miyasaka, Kohei Nakata, Kenoki Ohuchida, Eishi Nagai, Yoshinao Oda, Shuji Shimizu, Masafumi Nakamura
BACKGROUND: Circumportal pancreas is a rare congenital pancreatic anomaly. The aim of this study was to clarify the clinical characteristics of patients with circumportal pancreases undergoing pancreatectomy. METHODS: The medical records of 508 patients who underwent pancreatectomy were retrospectively reviewed. The prevalence of circumportal pancreas and related anatomical variations were assessed. Surgical procedures and postoperative outcomes were compared in patients with and without circumportal pancreas...
November 15, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27803935/combining-donor-characteristics-with-immunohistological-data-improves-the-prediction-of-islet-isolation-success
#7
Zuzana Berkova, Frantisek Saudek, Peter Girman, Klara Zacharovova, Jan Kriz, Eva Fabryova, Ivan Leontovyc, Tomas Koblas, Lucie Kosinova, Tomas Neskudla, Ema Vavrova, David Habart, Sarka Loukotova, Martina Zahradnicka, Kvetoslav Lipar, Ludek Voska, Jelena Skibova
Variability of pancreatic donors may significantly impact the success of islet isolation. The aim of this study was to evaluate donor factors associated with isolation failure and to investigate whether immunohistology could contribute to organ selection. Donor characteristics were evaluated for both successful (n = 61) and failed (n = 98) islet isolations. Samples of donor pancreatic tissue (n = 78) were taken for immunohistochemical examination. Islet isolations with 250000 islet equivalents were considered successful...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27796420/insulitis-in-human-diabetes-a-histological-evaluation-of-donor-pancreases
#8
Marcus Lundberg, Peter Seiron, Sofie Ingvast, Olle Korsgren, Oskar Skog
AIMS/HYPOTHESIS: According to the consensus criteria developed for type 1 diabetes, an individual can be diagnosed with insulitis when ≥ 15 CD45(+) cells are found within the parenchyma or in the islet-exocrine interface in ≥ 3 islets. The aim of this study was to determine the frequency of individuals with type 2 diabetes fulfilling these criteria with reference to non-diabetic and type 1 diabetic individuals. METHODS: Insulitis was determined by examining CD45(+) cells in the pancreases of 50, 13 and 44 organ donors with type 2 diabetes, type 1 diabetes and no diabetes, respectively...
October 28, 2016: Diabetologia
https://www.readbyqxmd.com/read/27795463/histopathological-changes-in-the-pancreas-of-cattle-with-abdominal-fat-necrosis
#9
Chikako Tani, Watanyoo Pratakpiriya, Mineto Tani, Takenori Yamauchi, Takuya Hirai, Ryoji Yamaguchi, Hitoshi Ano, Hiromu Katamoto
The association between pancreatic disorder and abdominal fat necrosis in cattle remains unclear. The pancreases of 29 slaughtered cattle with or without fat necrosis were collected to investigate pathological changes. Japanese Black (JB) cattle were classified into the FN group (with abdominal fat necrosis; n=9) and N group (without fat necrosis; n=5). The pancreases were also collected from 15 Holstein Friesian (HF) cows. All JB cattle showed high body condition scores. Regarding the pathological findings, fatty pancreas which involves adipocyte infiltration into the pancreas and fat necrosis (saponification) were observed in 25 and 27 cases, respectively...
October 30, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27783386/characterization-of-resident-lymphocytes-in-human-pancreatic-islets
#10
Miljana Radenkovic, Kristina Uvebrant, Oskar Skog, Luis Sarmiento, Jeanette Avartsson, Peter Storm, Petter Vickman, Per-Anders Bertilsson, Malin Fex, Olle Korsgren, Corrado M Cilio
The current view of type 1 diabetes (T1D) is that it is an immune-mediated disease where lymphocytes infiltrate the pancreatic islets, promote killing of beta cells and cause overt diabetes. Although tissue resident immune cells have been demonstrated in several organs, the composition of lymphocytes in human healthy pancreatic islets have been scarcely studied. Here we aimed to investigate the phenotype of immune cells associated to human islets of non-diabetic organ donors. A flow cytometry analysis of isolated islets from perfused pancreases (n=38) was employed to identify alpha, beta, T, NK and B cells...
October 26, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27729841/in-silico-study-of-mirna-based-gene-regulation-involved-in-solid-cancer-by-the-assistance-of-argonaute-protein
#11
Surya Narayan Rath, Debasrita Das, V Badireenath Konkimalla, Sukanta Kumar Pradhan
Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer...
September 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/27709855/using-forceps-biopsy-after-small-submucosal-dissection-in-the-diagnosis-of-gastric-subepithelial-tumors
#12
Yoon Suk Jung, Hyuk Lee, Kyungeun Kim, Jin Hee Sohn, Hong Joo Kim, Jung Ho Park
The current tissue sampling techniques for subepithelial tumors (SETs) of the gastrointestinal (GI) tract have limited diagnostic efficacy. We evaluated the diagnostic yield and safety of forceps biopsies after small endoscopic submucosal dissection (SESD biopsies) in the diagnosis of gastric SETs. A total of 42 patients with gastric SETs > 10 mm were prospectively enrolled between May 2013 and October 2014. A dual knife was used to incise the mucosa and submucosa and forceps biopsies were then introduced deep into the lesion...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27659228/soluble-cd93-is-involved-in-metabolic-dysregulation-but-does-not-influence-carotid-intima-media-thickness
#13
Rona J Strawbridge, Agneta Hilding, Angela Silveira, Cecilia Österholm, Bengt Sennblad, Olga McLeod, Panagiota Tsikrika, Fariba Foroogh, Elena Tremoli, Damiano Baldassarre, Fabrizio Veglia, Rainer Rauramaa, Andries J Smit, Phillipe Giral, Sudhir Kurl, Elmo Mannarino, Enzo Grossi, Ann-Christine Syvänen, Steve E Humphries, Ulf de Faire, Claes-Göran Östenson, Lars Maegdefessel, Anders Hamsten, Alexandra Bäcklund
Type 2 diabetes and cardiovascular disease are complex disorders involving metabolic and inflammatory mechanisms. Here we investigated whether sCD93, a group XIV c-type lectin of the endosialin family, plays a role in metabolic dysregulation or carotid intima-media thickness (IMT). Although no association was observed between sCD93 and IMT, sCD93 levels were significantly lower in subjects with type 2 diabetes (n = 901, mean ± SD 156.6 ± 40.0 ng/mL) compared with subjects without diabetes (n = 2,470, 164...
October 2016: Diabetes
https://www.readbyqxmd.com/read/27617438/angiopoetin-2-signals-do-not-mediate-the-hypervascularization-of-islets-in-type-2-diabetes
#14
Payal Shah, Navina Lueschen, Amin Ardestani, Jose Oberholzer, Johan Olerud, Per-Ola Carlsson, Kathrin Maedler
AIMS: Changes in the islet vasculature have been implicated in the regulation of β-cell survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to compensate for the increased insulin demand in obesity eventually leads to diabetes; as a result of the complex interplay of genetic and environmental factors (e.g. ongoing inflammation within the islets) and impaired vascular function. The Angiopoietin/Tie (Ang/Tie) angiogenic system maintains vasculature and is closely related to organ inflammation and angiogenesis...
2016: PloS One
https://www.readbyqxmd.com/read/27617172/the-role-of-adipose-derived-inflammatory-cytokines-in-type-1-diabetes
#15
REVIEW
Lan Shao, Boya Feng, Yuying Zhang, Huanjiao Zhou, Weidong Ji, Wang Min
Adipose tissue dysfunction correlates with the development of diabetes. Mice with an adipocyte-specific deletion of the SUMO-specific protease SENP1 develop symptoms of type-1 diabetes mellitus (T1DM). Peri-pancreatic adipocytes (PATs) exert both systemic and paracrine effects on pancreases function. Our recent studies report that PATs of SENP1-deficient mice have increased proinflammatory cytokine production compared with other adipose depots. Proinflammatory cytokines produced from PATs not only have direct cytotoxic effects on pancreatic islets, but also increase CCL5 expression in adjacent pancreatic islets, which induces persistent inflammation in pancreases by acquisition of Th1 and Th17 effector T cell subsets...
July 2016: Adipocyte
https://www.readbyqxmd.com/read/27583852/optimal-stapler-cartridge-selection-according-to-the-thickness-of-the-pancreas-in-distal-pancreatectomy
#16
Hongbeom Kim, Jin-Young Jang, Donghee Son, Seungyeoun Lee, Youngmin Han, Yong Chan Shin, Jae Ri Kim, Wooil Kwon, Sun-Whe Kim
Stapling is a popular method for stump closure in distal pancreatectomy (DP). However, research on which cartridges are suitable for different pancreatic thickness is lacking. To identify the optimal stapler cartridge choice in DP according to pancreatic thickness.From November 2011 to April 2015, data were prospectively collected from 217 consecutive patients who underwent DP with 3-layer endoscopic staple closure in Seoul National University Hospital, Korea. Postoperative pancreatic fistula (POPF) was graded according to International Study Group on Pancreatic Fistula definitions...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27559239/a-comparison-of-the-anatomical-structure-of-the-pancreas-in-experimental-animals
#17
REVIEW
Minoru Tsuchitani, Junko Sato, Hiroko Kokoshima
As basic knowledge for evaluation of pancreatic toxicity, anatomical structures were compared among experimental animal species, including rats, dogs, monkeys, and minipigs. In terms of gross anatomy, the pancreases of dogs, monkeys, and minipigs are compact and similar to that of humans. The rat pancreas is relatively compact at the splenic segment, but the duodenal segment is dispersed within the mesentery. In terms of histology, the islet of each animal is characterized by a topographic distribution pattern of α- versus β-cells...
July 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/27520508/dual-actions-of-netrin-1-on-islet-insulin-secretion-and-immune-modulation
#18
Shan Gao, Xiuyuan Zhang, Yibo Qin, Shixin Xu, Ju Zhang, Zhihong Wang, Weiwei Wang, Deling Kong, Chen Li
Netrin-1 is typically known as a neural guidance cue, which has been implicated in pancreas development. Since regenerative, angiogenic and anti-inflammatory properties of Netrin-1 have been reported in multiple tissues, we have investigated the potential role of Netrin-1 in the endocrine islet and its implication in mice with high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Effects of exogenous Netrin-1 on β-cell [Ca(2+)]i, cyclic AMP (cAMP) and insulin production were assessed in vitro The long-term impact of Netrin-1 treatment was then evaluated in HFD/STZ-induced diabetic mice by subcutaneous implantation of osmotic minipumps which release Netrin-1 in a sustained manner for 4 weeks...
November 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27506584/islet-cell-hyperexpression-of-hla-class-i-antigens-a-defining-feature-in-type-1-diabetes
#19
Sarah J Richardson, Teresa Rodriguez-Calvo, Ivan C Gerling, Clayton E Mathews, John S Kaddis, Mark A Russell, Marie Zeissler, Pia Leete, Lars Krogvold, Knut Dahl-Jørgensen, Matthias von Herrath, Alberto Pugliese, Mark A Atkinson, Noel G Morgan
AIMS/HYPOTHESIS: Human pancreatic beta cells may be complicit in their own demise in type 1 diabetes, but how this occurs remains unclear. One potentially contributing factor is hyperexpression of HLA class I antigens. This was first described approximately 30 years ago, but has never been fully characterised and was recently challenged as artefactual. Therefore, we investigated HLA class I expression at the protein and RNA levels in pancreases from three cohorts of patients with type 1 diabetes...
November 2016: Diabetologia
https://www.readbyqxmd.com/read/27470559/bauhinia-variegata-caesalpiniaceae-leaf-extract-an-effective-treatment-option-in-type-i-and-type-ii-diabetes
#20
Yogesh A Kulkarni, Mayuresh S Garud
Among various metabolic disorders, diabetes mellitus is one of the most common disorder. Present study was designed to evaluate the effectiveness of aqueous extract of Bauhinia variegata leaves (AE) in animal models of type I and type II diabetes. Type I diabetes was induced by streptozotocin at the dose of 55mg/kg (i.p.) in male Sprague Dawley rats while type II diabetes was induced by high fat diet and streptozotocin at the dose of 35mg/kg (i.p.). Diabetic animals were treated with AE at the dose of 250, 500 and 1000mg/kg...
June 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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