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https://www.readbyqxmd.com/read/29657313/curcumin-attenuates-inflammation-in-a-severe-acute-pancreatitis-animal-model-by-regulating-traf1-ask1-signaling
#1
Shuo Yu, Min Wang, Xingjun Guo, Renyi Qin
BACKGROUND Inflammation plays an important role in initiation and development of severe acute pancreatitis (SAP). Curcumin exerts potent anti-inflammatory effects in many diseases, including acute pancreatitis. However, the specific molecular mechanisms are not clear. MATERIAL AND METHODS Intra-biliopancreatic duct injection of taurocholate was used to establish an animal model of SAP. Curcumin was administrated to animals as pre-treatments. Concentrations of cytokines in serum and ascites were measured by enzyme-linked immunosorbent assay (ELISA)...
April 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29611212/design-of-bioartificial-pancreases-from-the-standpoint-of-oxygen-supply
#2
Hiroo Iwata, Yusuke Arima, Yusuke Tsutsui
A bioartificial pancreas (BAP), in which islets of Langerhans (islets) are enclosed in a semipermeable membrane, has been developed to realize islet transplantation without the use of immunosuppressive drugs. Although recent progress in induced pluripotent stem (iPS) and embryonic stem (ES) cells has attracted attention owing to the potential applications of these cells as insulin-releasing cells, concerns about the safety of implantation of these cells remain. The use of the BAP has the advantage of easy removal if insulin-releasing cells derived from iPS/ES cells undesirably proliferate and form tumors in the BAP...
April 2, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29603452/pancreas-preservation-fluid-microbial-contamination-is-associated-with-poor-islet-isolation-outcomes-a-multi-centre-cohort-study
#3
Raphael P H Meier, Diego O Andrey, Pamela Sun, Nadja Niclauss, Benoît Bédat, Sandrine Demuylder-Mischler, Sophie Borot, Pierre-Yves Benhamou, Anne Wojtusciszyn, Fanny Buron, Nadine Pernin, Yannick D Muller, Domenico Bosco, Christian van Delden, Thierry Berney
BACKGROUND: The microbiological safety of islet preparations is paramount. Preservation medium contamination is frequent and its impact on islet yield and function remains unclear. METHODS: Microbiological samples collected during islet isolations from 2006 to 2016 were analyzed and correlated to isolation and allo- and auto-transplantation outcomes. RESULTS: Microbial contamination of preservation medium was found in 64.4% of processed donor pancreases (291/452)...
March 30, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29493470/-transplantation-of-islets-of-langerhans-procedure-indications-and-challenges
#4
M F Nijhoff, V A L Huurman, J Dubbeld, A R van Erkel, T A Rabelink, M A Engelse, E J P de Koning
Pancreatic islet isolation and transplantation are complicated procedures, indicated for a carefully selected group of patients. After isolation from the pancreas, the islets are infused into the portal vein. Allogeneic islet transplantation is performed in patients with diabetes mellitus, who suffer from severe hypoglycaemic events and/or progressive complications. One or more donor pancreases are used, which necessitates immunosuppressive treatment. In autologous islet transplantation, which is performed in patients in whom the pancreas has to be removed due to a non-malignant disease, the patients' own islets are isolated and reinfused...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29475006/glutamine-up-regulates-pancreatic-sodium-dependent-neutral-aminoacid-transporter-2-and-mitigates-islets-apoptosis-in-diabetic-rats
#5
Zekrayat J H Medras, Norhan M El-Sayed, Sawsan A Zaitone, Eman A Toraih, Manal M Sami, Yasser M Moustafa
BACKGROUND: Glutamine aminoacid regulates insulin exocytosis from pancreatic β-cells. Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue that has fascinated function in inhibiting β-cell apoptosis and preserving pancreatic β-cell mass. The present study investigated the benefit of adding glutamine to a regimen of liraglutide in diabetic rats focusing on their role in increasing insulin production and upregulation of the expression of sodium-dependent neutral aminoacid transporter-2 (SNAT2)...
October 25, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29460047/point-shear-wave-elastography-of-the-pancreas-in-patients-with-cystic-fibrosis-a-comparison-with-healthy-controls
#6
Matthias Hermann Christian Pfahler, Wolfgang Kratzer, Michael Leichsenring, Tilmann Graeter, Stefan Andreas Schmidt, Inka Wendlik, Elisabeth Lormes, Julian Schmidberger, Dorit Fabricius
PURPOSE: Manifestations of cystic fibrosis in the pancreas are gaining in clinical importance as patients live longer. Conventional ultrasonography and point shear wave elastography (pSWE) imaging are non-invasive and readily available diagnostic methods that are easy to perform. The aim of this study was to perform conventional ultrasonography and obtain pSWE values in the pancreases of patients with cystic fibrosis and to compare the findings with those of healthy controls. METHODS: 27 patients with cystic fibrosis (13 women/14 men; mean age 27...
February 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29427469/analysis-of-pancreatic-volume-in-acute-onset-slowly-progressive-and-fulminant-type-1-diabetes-in-a-japanese-population
#7
Hiroto Sasamori, Tomoyasu Fukui, Toshiyuki Hayashi, Takeshi Yamamoto, Makoto Ohara, Saki Yamamoto, Tetsuro Kobayashi, Tsutomu Hirano
BACKGROUND: A decrease in the size of the pancreas is observed in islet autoantibody-positive non-diabetic donors and acute-onset type 1 diabetes (AT1D) irrespective of the diabetes duration. Little is known, however, about the relationship between the size of the pancreas and T1D subtypes, including fulminant T1D (FT1D). METHODS: We examined the pancreatic volume (PV) in 44 adult patients with T1D (16 AT1D, 18 slowly progressive [SPT1D], and 10 FT1D) and 39 age- and BMI- matched non-diabetic controls...
February 10, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29415062/loss-of-intra-islet-heparan-sulfate-is-a-highly-sensitive-marker-of-type-1-diabetes-progression-in-humans
#8
Charmaine J Simeonovic, Sarah K Popp, Lora M Starrs, Debra J Brown, Andrew F Ziolkowski, Barbara Ludwig, Stefan R Bornstein, J Dennis Wilson, Alberto Pugliese, Thomas W H Kay, Helen E Thomas, Thomas Loudovaris, Fui Jiun Choong, Craig Freeman, Christopher R Parish
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently diagnosed T1D patients have only transiently and partially impacted the disease course, suggesting that other approaches are required. Our previous studies have demonstrated that heparan sulfate (HS), a glycosaminoglycan conventionally expressed in extracellular matrix, is present at high levels inside normal mouse beta cells. Intracellular HS was shown to be critical for beta cell survival and protection from oxidative damage...
2018: PloS One
https://www.readbyqxmd.com/read/29368270/vascularization-of-pancreatic-decellularized-scaffold-with-endothelial-progenitor-cells
#9
Yibing Guo, Cen Wu, Liancheng Xu, Yang Xu, Li Xiaohong, Zhu Hui, Lu Jingjing, Yuhua Lu, Zhiwei Wang
Vascularization remains a large obstacle for creating a functional pancreas-tissue equivalent for transplantation. In this study, a pre-vascularized pancreatic decellularized scaffold was prepared through endothelializing with endothelial progenitor cells (EPCs) in a bioreactor, and the ability to regenerate new blood vessels was detected in vivo. Initially, pancreases of Sprague-Dawley (SD) rats were perfused with 1% Triton X-100 and 0.1% ammonium hydroxide to remove the cellular components while the intact vascular network was preserved...
January 24, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29354869/organ-donor-pancreases-for-the-study-of-human-islet-cell-histology-and-pathophysiology-a-precious-and-valuable-resource
#10
EDITORIAL
Piero Marchetti, Mara Suleiman, Lorella Marselli
Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological hurdles. To date, most of the information that has been generated is derived from histological studies performed on pancreatic tissue from autopsy, surgery, in vivo biopsy or organ donation. Each approach has its advantages and disadvantages (as summarised in this commentary); however, in this edition of Diabetologia, Kusmartseva et al ( https://doi.org/10...
April 2018: Diabetologia
https://www.readbyqxmd.com/read/29338697/additional-dexamethasone-in-chemotherapies-with-carboplatin-and-paclitaxel-could-reduce-the-impaired-glycometabolism-in-rat-models
#11
Yanxiu Guo, Haoxia Zeng, Xiaohong Chang, Chaohua Wang, Heng Cui
BACKGROUND: Side-effects have been considered as the limitation of the chemotherapy agents' administration and life quality in patients with ovarian cancers. In order to explore the influence of the chemotherapy agents commonly used in ovarian cancer patients on the blood glucose metabolism in rat models, we conducted this study which simulated the conditions of clinical protocols. METHODS: Eighty clean-grade female Wistar rats were randomized into 8 groups: Group 1 (Negative control), Group 1' (Dexamethasone), Group 2 (Carboplatin), Group 2' (Carboplatin-plus-dexamethasone), Group 3 (Paclitaxel), Group 3' (Paclitaxel-plus-dexamethasone), Group 4 (Combined therapy), Group 4' (Combined-therapy-plus-dexamethasone)...
January 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29325720/development-of-pancreatic-machine-perfusion-translational-steps-from-porcine-to-human-models
#12
Karim Hamaoui, Sally Gowers, Bynvant Sandhu, Natalie Vallant, Terry Cook, Martyn Boutelle, Daniel Casanova, Vassilios Papalois
BACKGROUND: Hypothermic machine perfusion (HMP) is increasingly being used for extended criteria kidney grafts. Pancreatic HMP is challenging because physiologically the pancreas is a low-flow organ susceptible to edema. We report the successful development of preclinical HMP models using porcine pancreases, as well as human pancreases unsuitable for clinical transplantation. METHODS: Ten porcine pancreases were used in the development of these perfusion models...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29259102/altered-homeostasis-and-development-of-regulatory-t-cell-subsets-represent-an-il-2r-dependent-risk-for-diabetes-in-nod-mice
#13
Connor J Dwyer, Allison L Bayer, Carmen Fotino, Liping Yu, Cecilia Cabello-Kindelan, Natasha C Ward, Kevin H Toomer, Zhibin Chen, Thomas R Malek
The cytokine interleukin-2 (IL-2) is critical for the functions of regulatory T cells (Tregs ). The contribution of polymorphisms in the gene encoding the IL-2 receptor α subunit ( IL2RA ), which are associated with type 1 diabetes, is difficult to determine because autoimmunity depends on variations in multiple genes, where the contribution of any one gene product is small. We investigated the mechanisms whereby a modest reduction in IL-2R signaling selectively in T lymphocytes influenced the development of diabetes in the NOD mouse model...
December 19, 2017: Science Signaling
https://www.readbyqxmd.com/read/29251107/multicenter-assessment-of-animal-free-collagenase-af-1-for-human-islet-isolation
#14
Daniel Brandhorst, Géraldine Parnaud, Andrew Friberg, Vanessa Lavallard, Sandrine Demuylder-Mischler, Stephen Hughes, Julia Saphörster, Manfred Kurfürst, Olle Korsgren, Thierry Berney, Paul R V Johnson
Animal-free (AF) SERVA Collagenase AF-1 and Neutral Protease (NP) AF GMP Grade have recently become available for human islet isolation. This report describes the initial experiences of 3 different islet transplant centers. Thirty-four human pancreases were digested using 1 vial of the 6 different lots of Collagenase AF-1 (2,000-2,583 PZ-U/vial) supplemented with 4 different lots of NP AF in a range of 50 to 160 DMC-U per pancreas. Isolation, culture, and quality assessment were performed using standard techniques as previously described...
October 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29128936/hospital-time-prior-to-death-and-pancreas-histopathology-implications-for-future-studies
#15
Irina Kusmartseva, Maria Beery, Tiffany Philips, Stephen Selman, Priyanka Jadhav, Clive Wasserfall, Axel Muller, Alberto Pugliese, Jeffrey A Longmate, Desmond A Schatz, Mark A Atkinson, John S Kaddis
AIMS/HYPOTHESIS: Diabetes research studies routinely rely upon the use of tissue samples from human organ donors. It remains unclear whether the length of hospital stay prior to organ donation affects the presence of cells infiltrating the pancreas or the frequency of replicating beta cells. METHODS: To address this, 39 organ donors without diabetes were matched for age, sex, BMI and ethnicity in groups of three. Within each group, donors varied by length of hospital stay immediately prior to organ donation (<3 days, 3 to <6 days, or ≥6 days)...
April 2018: Diabetologia
https://www.readbyqxmd.com/read/29082247/interactive-segmentation-of-pancreases-in-abdominal-computed-tomography-images-and-its-evaluation-based-on-segmentation-accuracy-and-interaction-costs
#16
Hotaka Takizawa, Takenobu Suzuki, Hiroyuki Kudo, Toshiyuki Okada
The present paper proposed an interactive segmentation method of pancreases in abdominal computed tomography (CT) images based on the anatomical knowledge of medical doctors and the statistical information of pancreas shapes. This segmentation method consisted of two phases: training and testing. In the training phase, pancreas regions were manually extracted from sample CT images for training, and then a probabilistic atlas (PA) was constructed from the extracted regions. In the testing phase, a medical doctor selected seed voxels for a pancreas and background in a CT image for testing by use of our graphical user interface system...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29044985/beneficial-effect-of-recombinant-rc1rc2-collagenases-on-human-islet-function-efficacy-of-low-dose-enzymes-on-pancreas-digestion-and-yield
#17
Gopalakrishnan Loganathan, Venugopal Subhashree, Andrew G Breite, William W Tucker, Siddharth Narayanan, Maheswaran Dhanasekaran, SriPrakash Mokshagundam, Michael L Green, Michael G Hughes, Stuart K Williams, Francis E Dwulet, Robert C McCarthy, Appakalai N Balamurugan
A high number of human islets can be isolated by using modern purified tissue dissociation enzymes; however, this requires the use of >20 Wunsch units (WU)/g of pancreas for digestion. Attempts to reduce this dose have resulted in pancreas underdigestion and poor islet recovery but improved islet function. In this study, we achieved a high number of functional islets using a low dose of recombinant collagenase enzyme mixture (RCEM-1200 WU rC2 and 10 million collagen-degrading activity [CDA] U of rC1 containing about 209 mg of collagenase to digest a 100-g pancreas)...
February 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/28938416/pancreatic-histopathology-of-human-monogenic-diabetes-due-to-causal-variants-in-kcnj11-hnf1a-gata6-and-lmna
#18
May Sanyoura, Laura Jacobsen, David Carmody, Daniela Del Gaudio, Gorka Alkorta-Aranburu, Kelly Arndt, Ying Hu, Frances Kobiernicki, Irina Kusmartseva, Mark A Atkinson, Louis H Philipson, Desmond Schatz, Martha Campbell-Thompson, Siri Atma W Greeley
Context: Monogenic diabetes is thought to account for 2% of all diabetes cases, but most patients receive misdiagnoses of type 1 or type 2 diabetes. To date, little is known about the histopathological features of pancreata from patients with monogenic diabetes. Objective: Retrospective study of the JDRF Network for Pancreatic Organ Donors with Diabetes biorepository to identify possible cases of monogenic diabetes and to compare effects of genetic variants on pancreas histology...
January 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28926842/pharmacotherapy-with-thymoquinone-improved-pancreatic-%C3%AE-cell-integrity-and-functional-activity-enhanced-islets-revascularization-and-alleviated-metabolic-and-hepato-renal-disturbances-in-streptozotocin-induced-diabetes-in-rats
#19
Adel Galal El-Shemi, Osama Adnan Kensara, Aiman Alsaegh, Mohammed Hasan Mukhtar
AIMS: This study is aimed at evaluating the antidiabetic effects of thymoquinone (TQ) on streptozotocin (STZ)-induced diabetes in rats, and exploring the possible underlying mechanisms. METHODS: Diabetes was induced in adult male Wistar rats by intraperitoneal injection of freshly prepared STZ (65 mg/kg). After disease induction, 42 rats were equally assigned to: controls, STZ-diabetic group, and STZ-diabetic group treated with oral TQ (35 mg/kg/day) for 5 weeks...
2018: Pharmacology
https://www.readbyqxmd.com/read/28912479/late-stage-differentiation-of-embryonic-pancreatic-%C3%AE-cells-requires-jarid2
#20
Sara Cervantes, Marta Fontcuberta-PiSunyer, Joan-Marc Servitja, Rebeca Fernandez-Ruiz, Ainhoa García, Lidia Sanchez, Young-Sook Lee, Ramon Gomis, Rosa Gasa
Jarid2 is a component of the Polycomb Repressor complex 2 (PRC2), which is responsible for genome-wide H3K27me3 deposition, in embryonic stem cells. However, Jarid2 has also been shown to exert pleiotropic PRC2-independent actions during embryogenesis. Here, we have investigated the role of Jarid2 during pancreas development. Conditional ablation of Jarid2 in pancreatic progenitors results in reduced endocrine cell area at birth due to impaired endocrine cell differentiation and reduced prenatal proliferation...
September 14, 2017: Scientific Reports
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