Marat Slessarev, Katie L Bain, John Basmaji, Tom D Blydt-Hansen, Jessie Cooper, Frédérick D'Aragon, Lorenzo Del Sorbo, Amy Evans, Anthony C Gordon, Gail Klein, Maureen O Meade, Nicholas Murphy, Helen L Thomas, Matthew J Weiss, Charles Weijer, Dan Harvey
BACKGROUND: Donor interventions, including medications, protocols, and medical devices administered to donors, can enhance transplantable organ quality and quantity and maximize transplantation success. However, there is paucity of high-quality evidence about their effectiveness, in part because of ethical, practical, and regulatory challenges, and lack of guidance about conduct of donor intervention randomized controlled trials (RCTs). METHODS: With the vision to develop authoritative guidance for conduct of donor intervention RCTs, we convened a workshop of Canadian-United Kingdom experts in organ donation and transplantation ethics, research, and policy to identify stakeholders, explore unique challenges, and develop research agenda to inform future work in this promising field...
March 19, 2024: Transplantation