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research in infertility

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https://www.readbyqxmd.com/read/28441838/-evaluation-of-endometriosis-fertility-index-in-follow-up-treatment-of-endometriosis-combined-with-infertility-patients-after-laparoscopic-surgery
#1
R Y Qian, X Wu, J Sheng, P Zheng, Q Zhou, A H Duan, J P Zhang, Y L Zhang, D Lu
Objective: To explore the application of endometriosis fertility index (EFI) in guidance after laparoscopic surgery of endometriosis patients combined with infertility and to explore methods to improve pregnancy rate in different EFI groups. Methods: A prospective research was done in endometriosis patients combined with infertility in Beijing Obstetrics and Gynecology Hospital from January 2010 to June 2011, after laparoscopic surgery, these 146 patients were divided into 3 groups by EFI score. Using different pregnancy guidance, these patients had 5 years follow-up...
April 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28440264/use-of-testicular-sperm-for-intracytoplasmic-sperm-injection-in-men-with-high-sperm-dna-fragmentation-a-swot-analysis
#2
Sandro C Esteves, Matheus Roque, Nicolás Garrido
Spermatozoa retrieved from the testis of men with high levels of sperm DNA fragmentation (SDF) in the neat semen tend to have better DNA quality. Given the negative impact of SDF on the outcomes of Assisted Reproductive Technology (ART), an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection (Testi-ICSI). In this article, we used a SWOT (strengths, weaknesses, opportunities, and threats) analysis to summarize the advantages and drawbacks of this intervention...
April 18, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28436761/androgen-and-estrogen-shifts-in-men-before-and-after-bariatric-surgery-and-links-to-vitamins-and-trace-elements
#3
Alberto Rosenblatt, Joel Faintuch, Ivan Cecconello
Androgens and estrogens play a key role regarding sexual life and reproduction. Along with hypotestosteronemia, obese men exhibit a 2-fold increase in estradiol concentration, adversely infl uencing these parameters. Estrogens and adipokines also infl uence bone metabolism, exerting a direct effect on vitamin D, calcium homeostasis and bone health. Bariatric procedures normalize some sex hormones, and may reverse several obesity-related conditions. Estrogens levels may remain elevated postoperatively, and despite its protective effect on the skeleton, bariatric patients are more prone to fractures when compared to the general population...
April 24, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28435819/psychological-disorders-among-iranian-infertile-couples-undergoing-assisted-reproductive-technology-art
#4
Mansoureh Karimzadeh, Nasser Salsabili, Firouzeh Akbari Asbagh, Robab Teymouri, Golamreza Pourmand, Tahereh Soleimanieh Naeini
BACKGROUND: Worldwide, infertility affects 10%-15% of couples and most of them seek medical help including Assisted Reproductive Technology (ART) treatments. Undergoing ART treatments create many physical and emotional burdens. This study examined the psychological consequences of infertility in Iranian infertile males and females as well as their spouses, unlike previous studies that examined mainly females with infertility. METHODS: Subjects in this descriptive analytical design were recruited from the IVF Department of Mirza Koochak Khan Hospital and the Rouyesh Infertility Treatment Center of Tehran, Iran between Aug 2014 and Sep 2015...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28433374/peritoneal-fluid-cytokines-related-to-endometriosis-in-patients-evaluated-for-infertility
#5
Hilde Jørgensen, Abby S Hill, Michael T Beste, Manu P Kumar, Evan Chiswick, Peter Fedorcsak, Keith B Isaacson, Douglas A Lauffenburger, Linda G Griffith, Erik Qvigstad
OBJECTIVE: Our aim was to characterize peritoneal cytokine profiles in patients with infertility, with and without endometriosis, to illuminate potential differences in immune profiles that may reflect mechanistic differences between these two patient populations. DESIGN: Cross-sectional study. SETTING: University hospital and research center. PATIENT(S): Women undergoing laparoscopy for infertility investigation (n = 107)...
April 19, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28432722/efforts-to-redefine-endometriosis-prevalence-in-low-risk-patients
#6
Linnea R Goodman, Jason M Franasiak
Endometriosis has significant implications on patient health and well-being, particularly when it comes to pelvic pain and infertility. However, the true epidemiologic state of the disease has remained elusive. Many of the foundational studies characterize surgically confirmed endometriosis in highly selected patient populations. It has been hypothesized that the prevalence of endometriosis is approximately 10% (Vigano et al, Best Practices and Research in Clinical OB/GYN, 2004, 18(2):177-200) of reproductive aged women and may reach rates of 30-50% in symptomatic women...
April 22, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28431025/1h-magnetic-resonance-spectroscopy-of-live-human-sperm
#7
S Reynolds, S J Calvert, M N Paley, A A Pacey
STUDY QUESTION: Can 1H Magnetic Resonance Spectroscopy (MRS) be used to obtain information about the molecules and metabolites in live human spermatozoa? SUMMARY ANSWER: Percoll-based density gradient centrifugation (DGC) followed by a further two washing steps, yielded enough sperm with minimal contamination (<0.01%) from seminal fluid to permit effective MRS which detected significant differences (p < 0.05) in the choline/glycerophosphocholine, lipid and lactate regions of the 1H MRS spectrum between sperm in the pellet and those from the 40/80% interface...
April 18, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28417349/a-higher-prevalence-of-endometriosis-among-asian-women-does-not-contribute-to-poorer-ivf-outcomes
#8
Ayae Yamamoto, Erica B Johnstone, Michael S Bloom, Heather G Huddleston, Victor Y Fujimoto
PURPOSE: The purpose of the study was to determine whether diagnosis of endometriosis or endometriosis with endometrioma influences in vitro fertilization (IVF) outcomes in an ethnically diverse population. METHODS: Women undergoing a first IVF cycle (n = 717) between January 1, 2008 and December 31, 2009, at a university-affiliated infertility clinic, were retrospectively assessed for an endometriosis diagnosis. Differences in prevalence of endometriosis by ethnicity were determined, as well as differences in IVF success by ethnicity, with a focus on country of origin for Asian women...
April 17, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28411496/exposure-to-environmental-noise-and-risk-for-male-infertility-a%C3%A2-2population-based-cohort-study
#9
Kyoung-Bok Min, Jin-Young Min
BACKGROUND: Noise is associated with poor reproductive health. A number of animal studies have suggested the possible effects of exposure to high noise levels on fertility; to date, a little such research has been performed on humans. OBJECTIVES: We examined an association between daytime and nocturnal noise exposures over four years (2002-2005) and subsequent male infertility. METHODS: We used the National Health Insurance Service-National Sample Cohort (2002-2013), a population-wide health insurance claims dataset...
April 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28410129/epigenetics-of-reproductive-infertility
#10
Laxmidhar Das, Sabnam Parbin, Nibedita Pradhan, Chahat Kausar, Samir K Patra
Infertility is a complex pathophysiological condition. It may caused by specific or multiple physical and physiological factors, including abnormalities in homeostasis, hormonal imbalances and genetic alterations. In recent times various studies implicated that, aberrant epigenetic mechanisms are associated with reproductive infertility. There might be transgenerational effects associated with epigenetic modifications of gametes and studies suggest the importance of alterations in epigenetic modification at early and late stages of gametogenesis...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28402544/angiotensin-1-7-in-human-follicular-fluid-correlates-with-oocyte-maturation
#11
Ines K Cavallo, Cynthia Dela Cruz, Marilene L Oliveira, Helen L Del Puerto, Júlia A Dias, Veronica N Lobach, Maíra Casalechi, Maria G Camargos, Adelina M Reis, Robson A Santos, Fernando M Reis
STUDY QUESTION: Do angiotensin (Ang)-(1-7) levels in human ovarian follicular fluid (FF) correlate with the number and proportion of mature oocytes obtained for IVF? SUMMARY ANSWER: The present study shows for the first time that Ang-(1-7) levels in human FF correlate with the proportion of mature oocytes collected upon ovarian stimulation for IVF. WHAT IS KNOWN ALREADY: Ang-(1-7) is an active peptide of the renin-angiotensin system that stimulates oocyte maturation in isolated rabbit and rat ovaries...
April 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28401811/hooked-on-a-feeling-exploring-desires-and-solutions-in-infertility-accounts-given-by-women-with-atypical-sex-development
#12
Lisa Guntram
Sociocultural meanings accorded to infertility, and rapid developments in assisted reproductive technologies, have long been central concerns in feminist and social scientific research. However, knowledge is scarce concerning how individuals make sense of infertility when it is disclosed in adolescence, for example as the result of an 'atypical' sex development, rather than as a result of failed conception. This article examines how understandings of desires, kinship and 'solutions' take shape and are negotiated in the accounts women give of infertility resulting from 'atypical' sex development...
January 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28398666/association-between-a-maternal-history-of-miscarriages-and-birth-defects
#13
Hebe Campaña, Monica Rittler, Juan A Gili, Fernando A Poletta, Mariela S Pawluk, Lucas G Gimenez, Viviana R Cosentino, Eduardo E Castilla, Jorge S López Camelo
BACKGROUND: Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular, it examined whether the risk depended on the number of losses, and to suggest the existence of specific factors for each BD/miscarriage association observed...
March 1, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28397238/-progress-in-research-on-meiotic-genes-underlying-primary-ovarian-insuffiency
#14
Yufei Xu, Jian Wang
Primary ovarian insuffiency (POI), which accounts for female infertility, is characterized by amenorrhea before the age of 40 and high serum level of follicular stimulating hormone (>40 U/L) at two measurements taken at least one month apart. The disorder is believed to have a strong genetic component. A large number of candidate genes have been proposed, though few of them were extensively studied. With the rapid evolvement of genome sequencing technology, recent research raised the possibility that the genes involved in essential steps of meiosis such as chromosome synapsis and recombination play an important role in the pathogenesis of POI...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28395323/defining-the-human-sperm-microtubulome-an-integrated-genomics-approach%C3%A2
#15
Fanny Jumeau, Frédéric Chalmel, Francisco-Jose Fernandez-Gomez, Céline Carpentier, Hélène Obriot, Meryem Tardivel, Marie-Laure Caillet-Boudin, Jean-Marc Rigot, Nathalie Rives, Luc Buée, Nicolas Sergeant, Valérie Mitchell
Sperm motility notably depends on the structural integrity of the flagellum and the regulation of microtubule dynamics. Although researchers have started to use "omics" techniques to characterize the human sperm's molecular landscape, the constituents responsible for the assembly, organization, and dynamics of the flagellum microtubule have yet to be fully defined. In this study, we defined a core set of 116 gene products associated with the human sperm microtubulome (including products potentially involved in abnormal ciliary phenotypes and male infertility disorders)...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28395322/de-and-recellularization-of-the-pig-uterus-a-bioengineering-pilot-study%C3%A2
#16
Hannes Campo, Pedro M Baptista, Nuria López-Pérez, Amparo Faus, Irene Cervelló, Carlos Simón
Absolute uterine factor infertility, or the absence of a functional uterus, has a prevalence of 3%-5% in the general population. Despite the great strides being made in reproductive medicine, patients diagnosed with absolute uterine factor infertility remain untreatable. The only available solution has been gestational surrogacy, but recently the Brannström group presented a viable alternative by reporting the first successful live birth after uterus transplantation. Similar to other transplantations, this approach has inherent limitations such as the paucity of donor organs and the need for long-term immunosuppression...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28394547/influence-of-male-obesity-on-fertility
#17
Miro Kasum, Sonja Anić-Jurica, Ermin Čehić, Tajana Klepac-Pulanić, Josip Juras, Kristina Žužul
The aim of this review is to analyze current diagnostic approaches to obesity in adult men, the potential mechanisms linking obesity to infertility, and treatment options aimed at improving reproductive health. Obesity has become a worldwide epidemic with the estimated prevalence increasing from 28.8% to 36.9% between 1980 and 2013. In terms of diagnosis, numerous simple techniques have been developed including body mass index, waist to hip ratio, waist circumference, bioelectrical impedance analysis, ultrasound and skinfold measurements...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28394112/effect-of-familial-mediterranean-fever-on-ivf-outcome-a-retrospective-case-series
#18
Nafiye Karakas Yilmaz, Mustafa Kara, Metin Kaba, Bugra Coskun, Selcuk Erkilinc, Salim Erkaya
Although the in vitro fertilization-intra-cytoplasmic sperm injection (IVF-ICSI) has been utilized widely, the management in patients with an autoimmune disease is still a challenge. The aim of this study was to demonstrate IVF-ICSI outcomes in infertile women with familial Mediterranean fever (FMF). Patient data were collected from the cases registered from January 2006 until January 2014. A total of 6152 assisted reproductive technology (ART) cycles were analyzed retrospectively in the Ankara Zekai Tahir Burak Women’s Health Education and Research Hospital...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28391738/acupuncture-in-reproductive-medicine-the-motivations-of-infertile-women-to-participate-in-a-randomised-controlled-trial
#19
Sheryl L de Lacey, Elizabeth Sanderman, Caroline A Smith
INTRODUCTION: Randomised controlled trials are the gold standard in medical research and are challenging to conduct successfully since high numbers of participants are needed to produce robust results. Therefore, it is important to understand what motivates patients to participate in one, particularly in Reproductive Medicine where the conduct of RCTs is rare. Just as it is important to evaluate medical interventions, it is equally important that adjuvant therapies are properly assessed...
April 10, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28390288/automatic-classification-of-human-sperm-head-morphology
#20
Violeta Chang, Laurent Heutte, Caroline Petitjean, Steffen Härtel, Nancy Hitschfeld
BACKGROUND AND OBJECTIVE: Infertility is a problem that affects up to 15% of couples worldwide with emotional and physiological implications and semen analysis is the first step in the evaluation of an infertile couple. Indeed the morphology of human sperm cells is considered to be a clinical tool dedicated to the fertility prognosis and serves, mainly, for making decisions regarding the options of assisted reproduction technologies. Therefore, a complete analysis of not only normal sperm but also abnormal sperm turns out to be critical in this context...
April 2, 2017: Computers in Biology and Medicine
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