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research in infertility

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https://www.readbyqxmd.com/read/29471449/obesity-associated-advanced-glycation-end-products-within-the-human-uterine-cavity-adversely-impact-endometrial-function-and-embryo-implantation-competence
#1
Gabriella S Antoniotti, Melinda Coughlan, Lois A Salamonsen, Jemma Evans
STUDY QUESTION: Do obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development? SUMMARY ANSWER: Obese levels of AGEs activate inflammatory signaling (p65 NFκB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29470702/the-mutual-benefits-of-research-in-wild-animal-species-and-human-assisted-reproduction
#2
REVIEW
P Comizzoli, E E Paulson, L K McGinnis
Studying the reproductive biology of wild animal species produces knowledge beneficial to their management and conservation. However, wild species also share intriguing similarities in reproductive biology with humans, thereby offering alternative models for better understanding the etiology of infertility and developing innovative treatments. The purpose of this review is to raise awareness in different scientific communities about intriguing connections between wild animals and humans regarding infertility syndromes or improvement of fertility preservation...
February 22, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29469992/reproductive-outcome-of-patients-undergoing-in-vitro-fertilization-treatment-and-diagnosed-with-bacterial-vaginosis-or-abnormal-vaginal-microbiota-a-systematic-prisma-review-and-meta-analysis
#3
Thor Haahr, Jane Zacho, Merethe Bräuner, K Shathmigha, Jørgen Skov Jensen, Peter Humaidan
BACKGROUND: Despite recent efforts, the risks associated with bacterial vaginosis (BV) or abnormal vaginal microbiota in IVF patients are not well-established. OBJECTIVES: We aimed to evaluate the risks associated with BV in IVF patients using meta-analysis. SEARCH STRATEGY: Following preliminary searches in order to find relevant key words and MeSH terms, a systematic search was performed in Pubmed (Medline) September 2017. SELECTION CRITERIA: The population was infertile women attending IVF treatment...
February 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29463301/molecular-detection-of-colistin-resistance-genes-mcr-1-to-mcr-5-in-human-vaginal-swabs
#4
Jilei Zhang, Li Chen, Jiawei Wang, Patrick Butaye, Ke Huang, Haixiang Qiu, Xiaomei Zhang, Weijuan Gong, Chengming Wang
OBJECTIVE: Colistin resistance has emerged worldwide and has been threatening the efficacy of one of the last-resort antimicrobials used for treatment of multidrug resistant Gram-negative bacteria. While five colistin resistance genes (mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5) have been described, few data are available on the prevalence of mcr-genes other than mcr-1 in human samples. RESULTS: In this study, the presence of five currently described colistin resistance genes (mcr 1-5) in vaginal swabs of women undergoing infertility evaluation was reported...
February 20, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29462326/secreted-frizzled-related-protein-2-sfrp2-expression-promotes-lesion-proliferation-via-canonical-wnt-signaling-and-indicates-lesion-borders-in-extraovarian-endometriosis
#5
T Heinosalo, M Gabriel, L Kallio, P Adhikari, K Huhtinen, T D Laajala, E Kaikkonen, A Mehmood, P Suvitie, H Kujari, T Aittokallio, A Perheentupa, M Poutanen
STUDY QUESTION: What is the role of SFRP2 in endometriosis? SUMMARY ANSWER: SFRP2 acts as a canonical WNT/CTNNB1 signaling agonist in endometriosis, regulating endometriosis lesion growth and indicating endometriosis lesion borders together with CTNNB1 (also known as beta catenin). WHAT IS KNOWN ALREADY: Endometriosis is a common, chronic disease that affects women of reproductive age, causing pain and infertility, and has significant economic impact on national health systems...
February 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29462236/sperm-egg-interaction-and-fertilization-past-present-and-future
#6
Masaru Okabe
Fifty years have passed since the findings of capacitation and acrosome reaction. These discoveries and the extensive effort of researchers led to the success of in vitro fertilization (IVF), which has become a top choice for patients at infertility clinics today. The effort to understand the mechanism of fertilization is ongoing, but the small number of eggs and similarly small quantity of spermatozoa continue to hinder biochemical experiments. The emergence of transgenic animals and gene disruption techniques have had a significant effect on fertilization research...
February 15, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29460468/review-of-the-role-of-leptin-in-the-regulation-of-male-reproductive-function
#7
REVIEW
J Zhang, M Gong
Since discovered in 1994, leptin has been thought to be a pleiotropic hormone that regulates food intake, controls energy balance in the body and influences multiple tissues in the body. Leptin plays an important mediating role in the regulation of neuroendocrine and can transmit the nutritional status signals to the reproductive-related central nervous system. Many studies have shown that leptin may play an important role in the control of reproductive function. Leptin can act on all levels of the hypothalamus-pituitary-gonadal (HPG) axis and may have local effects on the function of testis and spermatogenesis...
February 20, 2018: Andrologia
https://www.readbyqxmd.com/read/29460046/multiparametric-us-for-scrotal-diseases
#8
Michele Bertolotto, Matilda Muça, Francesca Currò, Stefano Bucci, Laurence Rocher, Maria Assunta Cova
Multiparametric US is increasingly recognized as a valuable problem-solving technique in scrotal pathologies. Compared to conventional Doppler modes, contrast-enhanced ultrasonography (CEUS) has higher sensitivity in assessing the presence or absence of flows, and to improve differentiation between poorly vascularized tumors and non-neoplastic, avascular lesions. Characterization of benign and malignant complex cysts is improved. In trauma patients, CEUS can help evaluating the viability of testicular parenchyma...
February 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29452361/iui-review-and-systematic-assessment-of-the-evidence-that-supports-global-recommendations
#9
Ben Cohlen, Aartjan Bijkerk, Sheryl Van der Poel, Willem Ombelet
BACKGROUND: IUI with or without ovarian stimulation (OS) has become a first-line treatment option for many infertile couples, worldwide. The appropriate treatment modality for couples and their clinical management through IUI or IUI/OS cycles must consider maternal and perinatal outcomes, most notably the clinical complication of higher-order multiple pregnancies associated with IUI-OS. With a current global emphasis to continue to decrease maternal and perinatal mortality and morbidity, the World Health Organization (WHO) had established a multi-year project to review the evidence for the establishment of normative guidance for the implementation of IUI as a treatment to address fertility problems, and to consider its cost-effectiveness for lower resource settings...
February 14, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29448896/circulating-neutrophil-extracellular-traps-are-elevated-in-patients-with-deep-infiltrating-endometriosis
#10
Jordina Munrós, Dolors Tàssies, Joan Carles Reverter, Lidia Martin, Amelia Pérez, Francisco Carmona, María Ángeles Martínez-Zamora
Neutrophil extracellular traps (NETs) have been described to be related to the pathogenesis of inflammatory and autoimmune conditions. Endometriosis is currently considered a chronic inflammatory condition. Therefore, we performed a preliminary case-control study to compare the circulating plasma NET levels in patients with surgically confirmed endometriosis (E group, n = 82) and those of patients without surgical findings of endometriosis (C group, n = 35). Venous blood samples were obtained at the time of surgery...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29447380/sirtuins-in-gamete-biology-and-reproductive-physiology-emerging-roles-and-therapeutic-potential-in-female-and-male-infertility
#11
Carla Tatone, Giovanna Di Emidio, Arcangelo Barbonetti, Gaspare Carta, Alberto M Luciano, Stefano Falone, Fernanda Amicarelli
BACKGROUND: Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of fertility emerged in 2003 when a defective reproductive phenotype was observed in SIRT1-null mice. Although studies on Sirtuins in reproductive biology have been increasing in the last years, a recent comprehensive update on this issue is still lacking...
February 13, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29444788/assessment-of-the-societal-and-individual-preferences-for-fertility-treatment-in-australia-study-protocol-for-stated-preference-discrete-choice-experiments
#12
Willings Botha, Natasha Donnolley, Marian Shanahan, Georgina M Chambers
INTRODUCTION: In Australia, societal and individual preferences for funding fertility treatment remain largely unknown. This has resulted in a lack of evidence about willingness to pay (WTP) for fertility treatment by either the general population (the funders) or infertile individuals (who directly benefit). Using a stated preference discrete choice experiment (SPDCE) approach has been suggested as a more appropriate method to inform economic evaluations of fertility treatment. We outline the protocol for an ongoing study which aims to assess fertility treatment preferences of both the general population and infertile individuals, and indirectly estimate their WTP for fertility treatment...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438472/klinefelter-syndrome-integrating-genetics-neuropsychology-and-endocrinology
#13
Claus H Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore, Anne Skakkebæk
Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also thought to play a role...
February 9, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29432754/optimizing-research-in-symptomatic-uterine-fibroids-with-development-of-a-computable-phenotype-for-use-with-electronic-health-records
#14
Sarah R Hoffman, Anissa I Vines, Jacqueline R Halladay, Emily Pfaff, Lauren Schiff, Daniel Westreich, Aditi Sundaresan, La-Shell Johnson, Wanda K Nicholson
BACKGROUND: Symptomatic uterine fibroids, due to menorrhagia, pelvic pain, bulk symptoms or infertility, are a source of substantial morbidity for reproductive-age women. Comparing Treatment Options for Uterine Fibroids (COMPARE-UF) is a multi-site registry study to compare the effectiveness of hormonal or surgical fibroid treatments on women's perceptions of their quality of life. Electronic health record (EHR)-based algorithms are able to identify large numbers of women with fibroids, but additional work is needed to develop EHR algorithms that can identify women with symptomatic fibroids to optimize fibroid research...
February 9, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29427904/lack-of-association-between-aryl-hydrocarbon-receptor-gene-arg554lys-polymorphism-and-male-infertility-risk-a-systematic-review-and-meta-analysis
#15
Yong Wei, Zheng Zhang, Guotao Chen, Leilei Zhu, Hesong Jiang, Baibing Yang, Yun Chen, Yutian Dai, Quanbing Chen
OBJECTIVES: The association between aryl hydrocarbon receptor gene (AhR) polymorphism and male infertility risk remains conflicting. We conducted a meta-analysis to examine the AhR Arg554Lys polymorphism in relation to the susceptibility to male infertility. STUDY DESIGN: Studies concerning the association between AHR polymorphism and male infertility were searched and related information were extracted from the included studies. The STATA 12.0 software was used to perform a meta-analysis...
January 31, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29425298/-man-up-the-importance-and-strategy-for-placing-male-reproductive-health-centre-stage-in-the-political-and-research-agenda
#16
Christopher L R Barratt, Christopher J De Jonge, Richard M Sharpe
Approximately 1 in 20 young men today have sperm counts low enough to impair fertility, whereas this may not have been the case historically. The cause(s) of such a decline in male reproductive health is unknown, despite it being a global health issue. Concomitantly, little progress has been made in answering fundamental questions in andrology or in developing new diagnostic tools or alternative management strategies to ICSI in infertile men. We advocate formulation of a detailed roadmap for male reproductive health to facilitate development of a research agenda that highlights the present unmet needs and key unanswered questions, and seeks to deliver effective funding and investment to address them...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29422703/responding-to-infertility-lessons-from-a-growing-body-of-research-and-suggested-guidelines-for-practice
#17
Karina M Shreffler, Arthur L Greil, Julia McQuillan
Infertility is a common, yet often misunderstood, experience. Infertility is an important topic for family scientists because of its effects on families; its relevance to research in related areas, such as fertility trends and reproductive health; and its implications for practitioners who work with individuals and couples experiencing infertility. In this review, we focus on common misperceptions in knowledge and treatment of infertility and highlight insights from recent research that includes men, couples, and people with infertility who are not in treatment...
October 2017: Family Relations
https://www.readbyqxmd.com/read/29422451/influence-of-radiofrequency-electromagnetic-fields-on-the-fertility-system-protocol-for-a-systematic-review-and-meta-analysis
#18
Nasibeh Roozbeh, Fatemeh Abdi, Azadeh Amraee, Zahra Atarodi Kashani, Leili Darvish
BACKGROUND: Due to the increased number of users of mobile phones, tablets, and other devices over the past few years, concerns about the potential impact of mobile phones on health are growing. The influence of mobile phone exposure on male fertility has been studied in recent years. Other research has shown that electromagnetic fields (EMFs) increase macrophages in the corpus luteum and growing follicles. Due to conflicting results among studies and since no systematic review has been performed to analyze the effects of radiofrequency EMF exposure from electronic devices on the fertility system in recent years, this evidence-based study is necessary...
February 8, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29422163/the-impact-of-complementary-therapies-on-psychosocial-factors-in-women-undergoing-in-vitro-fertilization-ivf-a-systematic-literature-review
#19
Jenna A LoGiudice, Jenna Massaro
AIM: This review evaluates the impact of complementary therapies on psychosocial factors in women undergoing IVF. BACKGROUND: According to the CDC, nearly 7% of married women in the United States face infertility. Approximately 1.5% of all infants born in the U.S. annually are conceived through assisted reproductive technologies (ART), such as IVF. Women undergoing ART report distress, anxiety, and depression related to their treatment. Stress has been cited as the top reason why women terminate treatment...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29421766/a-common-surfactant-used-in-food-packaging-found-to-be-toxic-for-reproduction-in-mammals
#20
Cristina Nerin, Elena Canellas, Paula Vera, Estefanía Garcia-Calvo, José Luis Luque-Garcia, Carmen Cámara, Raquel Ausejo, Joaquín Miguel, Noelia Mendoza
Migration from a multilayer plastic material intended for food contact showed that 2,4,7,9-tetramethyl-5-decyne-4,7-diol mixture (surfynol), used as a surfactant in the adhesive employed to build the multilayer, was transferred to water and other food simulants in contact with the plastic. When these multilayer plastics were used for containing seminal doses for artificial insemination, it was found that fertility was seriously damaged in terms of motility, acrosome integrity, mitochondrial activity and penetration capacity in the cells, thus affecting male fertility...
January 30, 2018: Food and Chemical Toxicology
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