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Herpes keratitis

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https://www.readbyqxmd.com/read/27911430/-clinical-presentations-of-herpes-zoster-ophthalmicus-diagnosis-and-therapy
#1
G M Chernakova, E A Kleshcheva, T B Semenova
: Approximately a quarter of the world's population at some point in life is at risk of developing shingles (Herpes Zoster). In 10-20% of cases the first branch of the trigeminal nerve gets involved (Herpes Zoster Ophthalmicus, HZO). Ophthalmic complications of HZO are able to cause a significant reduction in visual function. AIM: To study and summarize clinical features of HZO (including the rate of complications and their nature) and to determine the relationship between clinical and laboratory data from these patients...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27902849/oral-antivirals-for-preventing-recurrent-herpes-simplex-keratitis-in-people-with-corneal-grafts
#2
REVIEW
Uday K Bhatt, M N Abdul Karim, Jeremy I Prydal, Senthil V Maharajan, Usama Fares
BACKGROUND: Ocular herpes is a viral infection of the eye caused by the herpes simplex virus (HSV), a double-stranded DNA virus. Corneal scarring caused by herpes simplex keratitis (HSK) is the leading infectious cause of penetrating corneal graft in high-income countries. Acyclovir is an antiviral drug known to have a protective effect against recurrences in herpetic eye disease. While there are some studies which have evaluated the effects of intervention with oral antiviral in preventing such recurrences in people with corneal grafts, a systematic review of all comparative clinical trials has not been previously undertaken...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27867111/anti-inflammatory-activity-of-punica-granatum-l-pomegranate-rind-extracts-applied-topically-to-ex-vivo-skin
#3
David M J Houston, Joachim Bugert, Stephen P Denyer, Charles M Heard
Coadministered pomegranate rind extract (PRE) and zinc (II) produces a potent virucidal activity against Herpes simplex virus (HSV); however, HSV infections are also associated with localised inflammation and pain. Here, the objective was to determine the anti-inflammatory activity and relative depth penetration of PRE, total pomegranate tannins (TPT) and zinc (II) in skin, ex vivo. PRE, TPT and ZnSO4 were dosed onto freshly excised ex vivo porcine skin mounted in Franz diffusion cells and analysed for COX-2, as a marker for modulation of the arachidonic acid inflammation pathway, by Western blotting and immunohistochemistry...
November 17, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27863844/persistent-impairment-of-quality-of-life-in-patients-with-herpes-simplex-keratitis
#4
Clotilde Reynaud, Antoine Rousseau, Godefroy Kaswin, Mohamed M'garrech, Emmanuel Barreau, Marc Labetoulle
PURPOSE: To evaluate the quality of life (QoL) in patients with quiescent herpes simplex keratitis compared with control patients without ocular herpes. DESIGN: Prospective, case-control study. PARTICIPANTS: Thirty-three patients with a unilateral and relapsing herpes simplex keratitis (HSK group) that was quiescent during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (control group). Both groups were age and gender matched...
November 15, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27849421/management-of-neonatal-herpes-simplex-infection-a-rare-case-of-blepharoconjunctivitis-and-concurrent-epithelial-and-stromal-keratitis
#5
Rita J C Matos, Joana M S Pires, Dionísio Cortesão
No abstract text is available yet for this article.
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27832414/herpetiform-keratitis-and-palmoplantar-hyperkeratosis-warning-signs-for-richner-hanhart-syndrome
#6
Diogo C Soares, Mariana N Stroparo, Yu C Lian, Cristina Y Takakura, Sabrina Wolf, Regina Betz, Chong A Kim
Richner-Hanhart syndrome (RHS, tyrosinemia type II) is a rare, autosomal recessive inborn error of tyrosine metabolism caused by tyrosine aminotransferase deficiency. It is characterized by photophobia due to keratitis, painful palmoplantar hyperkeratosis, variable mental retardation, and elevated serum tyrosine levels. Patients are often misdiagnosed with herpes simplex keratitis. We report on a a boy from Brazil who presented with bilateral keratitis secondary to RHS, which had earlier been misdiagnosed as herpes simplex keratitis...
November 10, 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27830086/active-pedicle-epithelial-flap-transposition-combined-with-amniotic-membrane-transplantation-for-treatment-of-nonhealing-corneal-ulcers
#7
Ting Zhang, Yuexin Wang, Yanni Jia, Dongle Liu, Suxia Li, Weiyun Shi, Hua Gao
Introduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers. Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combined surgery were included. Postoperatively, ulcer healing time was detected by corneal fluorescein staining. Visual acuity, intraocular pressure, surgical complications, and recurrence were recorded. Corneal status was inspected by the laser scanning confocal microscopy and anterior segment optical coherence tomography (AS-OCT)...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27798158/loss-of-neurokinin-1-receptor-alters-ocular-surface-homeostasis-and-promotes-an-early-development-of-herpes-stromal-keratitis
#8
Subhash Gaddipati, Pushpa Rao, Andrew David Jerome, Bala Bharathi Burugula, Norma P Gerard, Susmit Suvas
Substance P neuropeptide and its receptor, neurokinin-1 receptor (NK1R), are reported to present on the ocular surface. In this study, mice lacking functional NK1R exhibited an excessive desquamation of apical corneal epithelial cells in association with an increased epithelial cell proliferation and increased epithelial cell density, but decreased epithelial cell size. The lack of NK1R also resulted in decreased density of corneal nerves, corneal epithelial dendritic cells (DCs), and a reduced volume of basal tears...
November 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27746299/long-term-outcomes-of-pediatric-penetrating-keratoplasty-for-herpes-simplex-virus-keratitis
#9
Juan Carlos Serna-Ojeda, Denise Loya-Garcia, Alejandro Navas, Alejandro Lichtinger, Arturo Ramirez-Miranda, Enrique O Graue-Hernandez
PURPOSE: To analyze the characteristics and long-term outcomes of patients that underwent pediatric penetrating keratoplasty (PPK) for herpes simplex virus (HSV) keratitis. DESIGN: Retrospective, interventional, consecutive case series. METHODS: Observational report of outcomes and findings for 9 patients with history of HSV keratitis that underwent PPK and were followed in a single institution. Difference between the median preoperative and final best-corrected visual acuity (BCVA) was assessed and the outcomes are reported...
October 14, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27741018/prevalence-of-ocular-manifestations-and-visual-outcomes-in-patients-with-herpes-zoster-ophthalmicus
#10
Simon K H Szeto, Tommy C Y Chan, Raymond L M Wong, Alex L K Ng, Emmy Y M Li, Vishal Jhanji
PURPOSE: To investigate the prevalence of ocular manifestations and visual outcomes in patients with herpes zoster ophthalmicus (HZO). METHODS: Consecutive cases diagnosed with HZO who attended 2 hospitals between July 1, 2011, and June 30, 2015, were retrospectively reviewed. Patient demographics, clinical presentations, and management were reviewed. The logistic regression model was used to estimate the odds ratio of visual loss with ocular manifestations. RESULTS: A total of 259 patients were included...
October 12, 2016: Cornea
https://www.readbyqxmd.com/read/27688274/clinical-spectrum-diagnostic-criteria-and-polymerase-chain-reaction-of-aqueous-humor-in-viral-and-toxoplasma-detection-in-fuchs-uveitis-syndrome
#11
Swapnali Sabhapandit, Somasheila I Murthy, Praveen K Balne, Virender Singh Sangwan, V Sumanth, Ashok K Reddy
AIM: The aim of this study is to describe the clinical features and diagnostic criteria of Fuchs' uveitis (FU) and to determine whether it has an association with virus and toxoplasma in the aqueous humor during cataract surgery. SETTING AND DESIGN: This is a prospective, case-control study. MATERIALS AND METHODS: Patients with FU (n = 25), anterior uveitis (n = 15), and no uveitis (normal) (n = 50) were included based on predefined inclusion and exclusion criteria for all three groups...
August 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27684823/clinical-evaluation-of-deep-anterior-lamellar-keratoplasty-using-glycerol-cryopreserved-corneal-tissues-for-refractory-herpetic-stromal-keratitis-an-observational-study
#12
Xin Liu, Qi Zhou, Xinyu Huang, Zhenxing Liu, Yanlong Bi
The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK using GCCTs at Shanghai Tongji Hospital from 2012 to 2015. The best spectacle corrected visual acuity, recurrent inflammation, graft status, postoperative central graft thickness, and pre/postoperative complications were detected...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27681121/immune-and-nonimmune-compartment-specific-interferon-responses-are-critical-determinants-of-herpes-simplex-virus-induced-generalized-infections-and-acute-liver-failure
#13
Zachary M Parker, Tracy Jo Pasieka, George A Parker, David A Leib
: The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes simplex encephalitis has been extensively studied, HSV-1 generalized infections and subsequent acute liver failure are less well understood. We previously demonstrated that IFN-αβγR(-/-) mice are exquisitely susceptible to liver infection following corneal infection with HSV-1...
December 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27668636/descemet-s-membrane-detachment-with-schisis-induced-by-phacoemulsification
#14
Wenjia Xie, Yesheng Xu, Yu-Feng Yao
PURPOSE: To describe a case of Descemet's membrane detachment and schisis (Descemet's membrane separated into multiple layers) with confirmation by high-definition anterior segment optical coherence tomography (AS-OCT) after phacoemulsification and intraocular lens implantation. CASE REPORT: A 72-year-old woman presented with persistent corneal edema after phacoemulsification. She was diagnosed with herpes simplex keratitis and had been unsuccessfully treated for 60 days in her local hospital...
December 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27598973/treatment-of-refractory-acute-retinal-necrosis-with-intravenous-foscarnet-or-cidofovir
#15
Tomasz P Stryjewski, Nathan L Scott, Miriam B Barshak, Ellis H Tobin, Joshua J Mali, Lucy H Young, C Stephen Foster, Ivana K Kim, Marlene L Durand
PURPOSE: To report use of intravenous foscarnet or cidofovir for the treatment of refractory acute retinal necrosis (ARN). METHODS: Retrospective chart review. RESULTS: Four immunocompetent men aged 45-90 years presented with ARN from 2008-2014. One patient with two prior episodes of herpes simplex virus (HSV) ARN developed ARN after 6 years of antiviral prophylaxis. His condition worsened on acyclovir followed by intravenous foscarnet but responded to intravenous cidofovir (final VA in involved eye 20/20)...
September 6, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27537375/volatile-organic-compound-gamma-butyrolactone-released-upon-herpes-simplex-virus-type-1-acute-infection-modulated-membrane-potential-and-repressed-viral-infection-in-human-neuron-like-cells
#16
Kevin Rochford, Feng Chen, Yan Waguespack, Robert W Figliozzi, Madan K Kharel, Qiaojuan Zhang, Miguel Martin-Caraballo, S Victor Hsia
Herpes Simplex Virus Type -1 (HSV-1) infections can cause serious complications such as keratitis and encephalitis. The goal of this study was to identify any changes in the concentrations of volatile organic compounds (VOCs) produced during HSV-1 infection of epithelial cells that could potentially be used as an indicator of a response to stress. An additional objective was to study if any VOCs released from acute epithelial infection may influence subsequent neuronal infection to facilitate latency. To investigate these hypotheses, Vero cells were infected with HSV-1 and the emission of VOCs was analyzed using two-dimensional gas chromatograph/mass spectrometry (2D GC/MS)...
2016: PloS One
https://www.readbyqxmd.com/read/27528053/microsporidial-stromal-keratitis-and-endophthalmitis-in-an-immunocompetent-patient
#17
Arjun B Sood, Matthew R Debiec, Steven Yeh, Hans E Grossniklaus, J Bradley Randleman
PURPOSE: The purpose of this study is to report a case of microsporidial endophthalmitis after penetrating keratoplasty in a healthy patient and discuss the management. METHODS: This is a case report. RESULTS: A 69-year-old healthy male underwent penetrating keratoplasty for corneal scar secondary to herpes stromal keratitis. He presented with features of acute graft rejection 3 years later. After failure of medical management, a repeat full thickness keratoplasty was performed...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27508424/quiescent-herpes-simplex-keratitis-reactivation-after-intravitreal-injection-of-dexamethasone-implant
#18
Denis Jusufbegovic, Shlomit Schaal
PURPOSE: To report reactivation of herpes simplex virus keratitis after the injection of dexamethasone implant (Ozurdex) and to raise the awareness of this potentially vision threatening side effect. METHODS: A 90-year-old man presented with ocular pain and tearing in the left eye 3 weeks after receiving a dexamethasone implant (Ozurdex) for the treatment of macular edema associated with branch retinal vein occlusion. The patient had a history of herpes simplex virus keratitis that was quiescent for more than 30 years...
August 9, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27497323/il-6-contributes-to-corneal-nerve-degeneration-after-herpes-simplex-virus-type-i-infection
#19
Ana J Chucair-Elliott, Jeremy Jinkins, Meghan M Carr, Daniel J J Carr
Herpes simplex virus type 1 (HSV-1) is a leading cause of neurotrophic keratitis characterized by decreased corneal sensation because of damage to the corneal sensory fibers. We and others have reported regression of corneal nerves during acute HSV-1 infection. To determine whether denervation is caused directly by the virus or indirectly by the elicited immune response, mice were infected with HSV-1 and topically treated with dexamethasone (DEX) or control eye drops. Corneal sensitivity was measured using a Cochet-Bonnet esthesiometer and nerve network structure via immunohistochemistry...
October 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27468096/-keratitis-infectious-or-autoimmune
#20
E M Messmer
Histopathological evaluation of ocular tissues is important in differentiating between infectious and autoimmune disease. Inflammation, necrosis and keratolysis are common to most forms of keratitis. Histopathology can be of great help in identifying the causative organism, establishing a final diagnosis and/or managing the patient with herpes simplex virus keratitis, mycotic keratitis, acanthamoeba keratitis or microsporidia keratoconjunctivitis. Important pathogenetic knowledge with therapeutic relevance has been gained from histopathological studies in nummular keratitis after epidemic keratoconjunctivitis and atopic keratoconjunctivitis...
July 2016: Klinische Monatsblätter Für Augenheilkunde
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