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Herpes keratitis

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https://www.readbyqxmd.com/read/29749113/clinical-translation-of-recommendations-from-randomised-trials-for-management-of-herpes-simplex-virus-keratitis
#1
Maria Cabrera-Aguas, Dana Robaei, Peter McCluskey, Stephanie Watson
IMPORTANCE: Standardise initial anti-viral therapy for herpes simplex keratitis (HSK) BACKGROUND: To determine prescribing trends for the management of HSK and compare the trends to available clinical trial evidence. DESIGN: Retrospective review of patients at the Sydney Eye Hospital, Australia. PARTICIPANTS: Three hundred and one eyes of 296 patients prescribed anti-virals for HSK aged 18 years and above, from January 1, 2012 to December 31, 2013...
May 10, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29708930/management-of-chronic-complications-associated-with-herpes-zoster-ophthalmicus
#2
Saujanya Vadoothker, Bennie H Jeng
PURPOSE OF REVIEW: Herpes zoster ophthalmicus (HZO) has the potential to cause significant visual morbidity and functional disability in patients with recalcitrant disease, keratitis, and postherpetic neuralgia. This article will review the current methods of prevention and treatment of anterior segment-related chronic complications of HZO. RECENT FINDINGS: HZO-related anterior segment ocular complications can range to include conjunctivitis, keratitis, and uveitis that can all be difficult to manage...
April 27, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29708929/surgical-management-of-herpetic-keratitis
#3
Sonal Tuli, Matthew Gray, Ankit Shah
PURPOSE OF REVIEW: The purpose of this review is to discuss the options for, and recent developments in, the surgical treatment of herpes keratitis. Although the mainstay of treatment of herpetic keratitis is topical or oral antiviral agents, surgical intervention may be necessary for corneal melting or long-term complications such as scarring, lipid keratopathy, necrotizing keratitis, and neurotrophic keratitis. RECENT FINDINGS: There are a number of surgical therapies available for herpes keratitis...
April 27, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29697435/management-of-herpes-simplex-virus-epithelial-keratitis
#4
Mehdi Roozbahani, Kristin M Hammersmith
PURPOSE: To review recent advancements in the management of herpes simplex virus (HSV) epithelial keratitis. RECENT FINDINGS: Trifluridine eye drop, acyclovir (ACV) ointment, ganciclovir gel, and oral ACV are still the main therapeutic agents. Cryopreserved amniotic membrane has been recently used as an adjuvant treatment. Resistance to ACV has become a concerning issue. The animal models of HSV vaccine are able to reduce HSV keratitis. New antivirals are under development...
April 24, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29676321/bilateral-herpes-simplex-keratitis-reactivation-after-lacrimal-gland-botulinum-toxin-injection
#5
Purvasha Narang, Swati Singh, Vikas Mittal
Botulinum toxin A (BTA) injections into lacrimal gland are being used for refractory epiphora due to intractable lacrimal disorders with success rates reported from 18% to 86%. Most common side effects are transient ptosis and diplopia. We report a case of a 59-year-old female injected with 2.5 units of BTA injection in each lacrimal gland for functional epiphora. The patient had a history of herpes simplex viral keratitis that was quiescent for more than 2 years. After 3 weeks, she developed reactivation of viral keratitis bilaterally, which was successfully managed with antivirals and topical steroids...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29656541/a-novel-herpesvirus-associated-with-chronic-superficial-keratitis-and-proliferative-conjunctivitis-in-a-great-horned-owl-bubo-virginianus
#6
Molly D Gleeson, Bret A Moore, Sydney G Edwards, Sarah Stevens, April L Childress, James F X Wellehan, Jessica Robertson, Christopher J Murphy, Michelle G Hawkins, Joanne Paul-Murphy
An adult great-horned owl (Bubo virginianus; GHOW) presented with a history of recurrent corneal ulceration of the right eye (OD). Findings included ulcerative superficial keratitis, proliferative conjunctivitis, and iris pigmentary changes. The ulcer was initially nonresponsive to medical therapy, but showed rapid and appropriate healing following diamond burr debridement. Proliferative conjunctivitis markedly improved following topical antiviral therapy with cidofovir 1%, interferon alpha 2B ophthalmic solutions, and oral l-lysine...
April 14, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29595763/epithelial-keratitis-after-cataract-surgery
#7
Yang K Cho, Jin W Kwon, Sneha Konda, Balamurali K Ambati
PURPOSE: To evaluate the incidence, related perioperative factors, clinical characteristics, and possible etiologies of epithelial keratitis after cataract surgery. METHODS: A retrospective chart review of 666 eyes in 666 patients who underwent cataract surgery was performed to evaluate the incidence of epithelial keratitis and related factors in the postoperative period. RESULTS: Postoperative epithelial keratitis developed in 15 eyes. Eleven of the 15 eyes were diagnosed with herpes simplex keratitis (HSK); 10 of the 11 eyes were diagnosed by polymerase chain reaction, and the remaining 1 eye by clinical diagnosis...
June 2018: Cornea
https://www.readbyqxmd.com/read/29552666/improvement-of-chronic-corneal-opacity-in-ocular-surface-disease-with-prosthetic-replacement-of-the-ocular-surface-ecosystem-prose-treatment
#8
Anna Cressey, Deborah S Jacobs, Crystal Remington, Karen G Carrasquillo
Purpose: To demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease. Observations: We undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December 2014. Patients were referred for ocular surface disease of various etiologies. Primary inclusion criterion was corneal opacity that improved with PROSE treatment...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29510455/a-20-year-experience-of-ocular-herpes-virus-detection-using-immunofluorescence-and-polymerase-chain-reaction
#9
Gita Satpathy, Himansu S Behera, Anjana Sharma, Abhisek K Mishra, Deepanshi Mishra, Namrata Sharma, Radhika Tandon, Tushar Agarwal, Jeewan S Titiyal
BACKGROUND: To detect the presence of herpes virus in corneal scrapings/corneal grafts of suspected herpetic keratitis patients attending the outpatient department/casualty of the Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi for the past 20 years with immunofluorescence assay and to analyse the efficacy of polymerase chain reaction over immunofluorescence for routine laboratory diagnosis in some of the specimens. METHODS: Corneal scrapings and corneal grafts were collected by the ophthalmologists from 1,926 suspected herpetic keratitis patients between 1996 and 2015, among whom 1,863 patients were processed with immunofluorescence assay and 302 patients were processed with polymerase chain reaction assay for the detection of herpes virus...
March 6, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29429293/-deep-anterior-lamellar-keratoplasty-combined-with-antiviral-therapy-in-the-treatment-of-severe-herpes-necrotizing-stromal-keratitis
#10
S X Li, J T Wang, Y Jiang, X Wang, W Y Shi
Objective: To evaluate the efficacy of modified deep lamellar keratoplasty (DLKP) combined with antiviral medications for severe herpes necrotizing stromal keratitis. Methods: Retrospective case series study. Modified DLKP was performed in combination with antiviral medications in fifty patients (50 eyes) with severe necrotizing stromal keratitis, which was unresponsive to systemic and topical antiviral treatment for 1 week, at Shandong Eye Hospital. Before surgery, the operated eyes were examined using slit-lamp microscopy...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29422758/localized-trichiasis-causing-focal-full-thickness-corneal-edema-endothelial-cell-loss-and-corneal-scarring-requiring-penetrating-keratoplasty
#11
Tiffany Sara Liu, Seth Meskin
The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Specular microscopy showed diffuse endothelial cell loss. He was treated with topical steroids and acyclovir with epilation of lashes. Anterior chamber paracentesis was negative for varicella-zoster virus, cytomegalovirus, and herpes simplex virus...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29417444/corneal-perforation-after-noncontact-tonometry-in-patients-with-active-recurrent-herpes-simplex-keratitis-case-report
#12
Napaporn Tananuvat, Atitaya Apivatthakakul, Chulaluck Tangmonkongvoragul
PURPOSE: To report iatrogenic complications and to review the potential complications caused by noncontact tonometry (NCT) in related literature. METHODS: This case report describes two cases of active recurrent herpes simplex keratitis (HSK) on top of a thin corneal scar. The cornea was perforated by the air pulse from the NCT, resulting in an air bubble in the anterior chamber. RESULTS: Both patients were diagnosed with active recurrent necrotizing stromal HSK on top of a thinned corneal scar after previous therapeutic treatment involving tissue adhesive glue with a bandage contact lens (BCL) to treat a perforated cornea...
February 7, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29380788/reactivation-of-herpes-simplex-viral-keratitis-following-the-botulinum-toxin-injection
#13
Muralidhar Ramappa, Peter Y Jiya, Sunita Chaurasia, Milind Naik, Savitri Sharma
We describe a case of 55-year-old male farmer presented with recurrent corneal abrasions with a spastic entropion in the left eye. Superior cornea showed typical nummular opacities suggestive resolved herpetic eye diseases. On further enquiry, he had similar episodes in the past. Contralateral eye was essentially normal. Following the botulinum toxin injection for the management of spastic entropion, subject developed reactivation of herpetic necrotizing stromal keratitis. Diagnostic corneal scrapings were negative for herpes simplex virus-1 antigen by immunofluorescence assay and for DNA by molecular techniques...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29375989/a-comparative-study-of-risk-factors-for-corneal-infection-in-diabetic-and-non-diabetic-patients
#14
Bin Wang, Shuo Yang, Hua-Lei Zhai, Yang-Yang Zhang, Chun-Xia Cui, Jun-Yi Wang, Li-Xin Xie
AIM: To compare the clinical characteristics of infectious keratopathy in type 2 diabetes mellitus (T2DM) and non-diabetes mellitus (NDM) and to investigate risk factors for infectious keratopathy in T2DM patients. METHODS: Totally 230 patients with T2DM and 168 with NDM diagnosed as infectious keratopathy were hospitalized at Qingdao Eye Hospital from 2001 to 2015. Data including sex, age, occupation, season, smoking and alcohol consumption habits, duration between onset and treatments, duration of hospitalization were collected...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29370719/immunization-with-dendritic-cell-based-dna-vaccine-prsc-nldc145-gd-il21-protects-mice-against-herpes-simplex-virus-keratitis
#15
Ru Tang, Yujia Zhai, Lili Dong, Tejsu Malla, Kai Hu
AIM: The aim of this study is to investigate the effects of constructed dendritic cell (DC)-based DNA vaccine (pRSC-NLDC145.gD-IL21) carried by chitosan nanoparticle in preventing primary or recurrent herpes simplex virus keratitis (HSK) in mice. METHODS: The expression of constructed plasmid 'pRSC-NLDC145.gD-IL21' was verified by western blot and immunofluorescence. Plasmids that were embedded in chitosan were inoculated to test its therapeutic effect against primary or recurrent HSK in mice...
March 2018: Immunotherapy
https://www.readbyqxmd.com/read/29345511/clinical-characteristics-of-herpes-simplex-virus-associated-anterior-uveitis
#16
Barbara Wensing, Manabu Mochizuki, Joke H De Boer
PURPOSE: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis. METHODS: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. RESULTS: It was observed that HSV anterior uveitis is mostly an acute unilateral disease mainly occurring in middle-aged people with a predominance in females...
January 18, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29332157/acanthamoeba-keratitis-in-porto-alegre-southern-brazil-28-cases-and-risk-factors
#17
Denise Leal Dos Santos, Sergio Kwitko, Diane Ruschel Marinho, Bruno Schneider de Araújo, Claudete Inês Locatelli, Marilise Brittes Rott
The increasing use of contact lenses worldwide has led to an increase in cases of Acanthamoeba keratitis, which are often associated with inappropriate cleaning of contact lenses and lens cases. This study aimed to retrospectively review 28 cases of Acanthamoeba keratitis in Porto Alegre (southern Brazil) and identify the risk factors and clinical outcomes of affected patients. Most patients had higher education (66.6%), all were users of contact lenses, mostly women (67.9%). Most patients were soft contact lens wearers (66...
March 2018: Parasitology Research
https://www.readbyqxmd.com/read/29329934/application-of-our-understanding-of-pathogenesis-of-herpetic-stromal-keratitis-for-novel-therapy
#18
Naveen K Rajasagi, Barry T Rouse
HSV-1 ocular infection can cause herpes stromal keratitis (SK), an immunopathological lesion. Frequent recurrences can lead to progressive corneal scaring which can result in vision impairment if left untreated. Currently, the acute and epithelial forms of SK are usually controlled using anti-viral drugs. However, chronic forms of SK which are inflammatory in nature, require the addition of a topical corticosteroid to the anti-viral treatment regimen. In this review, we highlight the essential events involved in SK pathogenesis which can be targeted for improved therapy...
January 9, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29305292/corneal-nerve-regeneration-after-herpes-simplex-keratitis-a-longitudinal-in-vivo-confocal-microscopy-study
#19
Hamid-Reza Moein, Ahmad Kheirkhah, Rodrigo T Muller, Andrea C Cruzat, Deborah Pavan-Langston, Pedram Hamrah
PURPOSE: To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). DESIGN: Prospective, longitudinal, cross sectional. METHODS: This study included 16 patients with a history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29298778/-acanthamoeba-keratitis-in-194-patients-risk-factors-for-bad-outcomes-and-severe-inflammatory-complications
#20
Nicole Carnt, Dana Robaei, Darwin C Minassian, John K G Dart
BACKGROUND/AIMS: To determine demographic and clinical features of patients with Acanthamoeba keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC). METHODS: A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined as those having one or more of the following: corneal perforation, keratoplasty, other surgery (except biopsy), duration of antiamoebic therapy (AAT) ≥10...
January 3, 2018: British Journal of Ophthalmology
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