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https://www.readbyqxmd.com/read/29423535/the-population-impact-of-rheumatic-and-musculoskeletal-diseases-in-relation-to-other-non-communicable-disorders-comparing-two-estimation-approaches
#1
Daniela Simões, Fábio Azevedo Araújo, Teresa Monjardino, Milton Severo, Ivo Cruz, Loreto Carmona, Raquel Lucas
The aim of this study was to quantify the population impact of rheumatic and musculoskeletal diseases (RMDs) with other non-communicable diseases (NCDs), using two complementary strategies: standard multivariate models based on global burden of disease (GBD)-defined groups vs. empirical mutually exclusive patterns of NCDs. We used cross-sectional data from the Portuguese Fourth National Health Survey (n = 23,752). Six GBD-defined groups were included: RMDs, chronic obstructive pulmonary disease or asthma, cancer, depression, diabetes or renal failure, and stroke or myocardial infarction...
February 8, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29413512/the-revised-gold-2017-copd-categorization-in-relation-to-comorbidities
#2
Kathrin Kahnert, Peter Alter, David Young, Tanja Lucke, Joachim Heinrich, Rudolf M Huber, Jürgen Behr, Margarethe Wacker, Frank Biertz, Henrik Watz, Robert Bals, Tobias Welte, Hubert Wirtz, Felix Herth, Jørgen Vestbo, Emiel F Wouters, Claus F Vogelmeier, Rudolf A Jörres
INTRODUCTION: The COPD classification proposed by the Global Initiative for Obstructive Lung Disease was recently revised, and the A to D grouping is now based on symptoms and exacerbations only. Potential associations with comorbidities have not been assessed so far. Thus the aim of the present study was to determine the relationship between the revised (2017) GOLD groups A-D and major comorbidities. METHODS: We used baseline data from the COPD cohort COSYCONET...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29413497/a-retrospective-cohort-study-in-severe-asthma-describing-commonly-measured-biomarkers-eosinophil-count-and-ige-levels
#3
John Haughney, Alyn Morice, Kevin G Blyth, Amanda J Lee, Alasdair Coutts, Eddie McKnight, Ian Pavord
BACKGROUND: Identifying asthma patients suitable for biologic therapy includes the assessment of blood biomarkers (IgE and eosinophils (EOS)). How they relate to each other is unclear. METHODS: This retrospective, database study used routinely collected clinical data to identify and evaluate an asthma cohort (classification code for asthma; ≥ 18 years; ≥1 prescription for asthma; ≥1 estimation of serum IgE, in 2 years prior to index date). Distribution into high and low IgE and EOS groups (IgE cut-point: > or ≤75 kU/L; EOS cut point: >or ≤400 μ/L), and characteristics by group are described...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29411238/hospital-level-care-at-home-for-acutely-ill-adults-a-pilot-randomized-controlled-trial
#4
David M Levine, Kei Ouchi, Bonnie Blanchfield, Keren Diamond, Adam Licurse, Charles T Pu, Jeffrey L Schnipper
BACKGROUND: Hospitals are standard of care for acute illness, but hospitals can be unsafe, uncomfortable, and expensive. Providing substitutive hospital-level care in a patient's home potentially reduces cost while maintaining or improving quality, safety, and patient experience, although evidence from randomized controlled trials in the US is lacking. OBJECTIVE: Determine if home hospital care reduces cost while maintaining quality, safety, and patient experience...
February 6, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29379281/2017-global-initiative-for-chronic-obstructive-lung-disease-reclassifies-half-of-copd-subjects-to-lower-risk-group
#5
Marieann Högman, Johanna Sulku, Björn Ställberg, Christer Janson, Kristina Bröms, Hans Hedenström, Karin Lisspers, Andrei Malinovschi
Background: Unlike the 2014 guidelines, the 2017 Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines have removed lung function from the risk assessment algorithm of patients with COPD. The aim of this investigation was to analyze the proportion of subjects who would change to a lower risk group when applying GOLD2017 and determine if they exhibit different characteristics in terms of inflammation, symptoms and comorbidity compared to the subjects who would remain in a high-risk group...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29368608/burden-of-asthma-and-copd-overlap-aco-in-taiwan-a-nationwide-population-based-study
#6
Sumitra Shantakumar, Raoh-Fang Pwu, Liesel D'Silva, Keele Wurst, Yao-Wen Kuo, Yen-Yun Yang, Yi-Chen Juan, K Arnold Chan
BACKGROUND: Patients with symptoms of both asthma and chronic obstructive pulmonary disease (COPD) may be classified with the term asthma-COPD overlap (ACO). ACO is of considerable interest as it is currently poorly characterised and has been associated with worse health outcomes and higher healthcare costs compared with COPD or asthma alone. Patients with ACO in Asia remain poorly described, and there is limited information regarding their resource utilisation compared with patients with asthma or COPD only...
January 25, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29319364/comparative-study-of-il-33-and-il-6-levels-in-different-respiratory-samples-in-mild-to-moderate-asthma-and-copd
#7
Katarzyna Gorska, Patrycja Nejman-Gryz, Magdalena Paplinska-Goryca, Piotr Korczynski, Monika Prochorec-Sobieszek, Rafal Krenke
IL-6 and IL-33 are involved in the inflammatory process in obstructive lung diseases. In contrast to IL-6, few data on the expression of IL-33 in different biological samples from asthma and COPD patients are available. The aim was to evaluate the expressions of IL-33 and IL-6 in bronchial mucosa and to compare these expressions with the concentrations of both cytokines in various respiratory samples from patients with mild-to-moderate asthma and COPD. Serum, induced sputum and exhaled breath condensate IL-6 and IL-33 levels, as well as their expression in bronchial mucosa were evaluated in 22 asthma and 33 COPD patients...
January 10, 2018: COPD
https://www.readbyqxmd.com/read/29279363/lack-of-benefit-of-heliox-during-mechanical-ventilation-of-subjects-with-severe-air-flow-obstruction
#8
James W Leatherman, Ramiro Saavedra Romero, Robert S Shapiro
BACKGROUND: The value of heliox (helium-oxygen mixture) for patients with severe air-flow obstruction is uncertain. The purpose of this study was to determine whether heliox could reduce the degree of hyperinflation and hypercapnia in mechanically ventilated patients with severe air-flow obstruction. METHODS: This was a single-center, prospective observational study conducted in a medical ICU of an academic medical center. We assessed the impact of heliox (65-70% helium, 30-35% oxygen) on airway pressures and arterial blood gases of 13 subjects undergoing mechanical ventilation for severe asthma (n = 8) or exacerbation of COPD (n = 5)...
December 26, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29246162/use-of-a-baseline-risk-score-to-identify-the-risk-of-serious-infectious-events-in-patients-with-rheumatoid-arthritis-during-certolizumab-pegol-treatment
#9
Jeffrey R Curtis, Kevin Winthrop, Cathy O'Brien, Matladi N Ndlovu, Marc de Longueville, Boulos Haraoui
BACKGROUND: The risk of serious infectious events (SIEs) is increased in patients with rheumatoid arthritis (RA). The aim of this study was to develop an age-adjusted comorbidity index (AACI) to predict, using baseline characteristics, the SIE risk in patients with RA treated with certolizumab pegol (CZP). METHODS: Data of CZP-treated patients with RA were pooled from the RAPID1/RAPID2 randomized controlled trials (RCT CZP) and their open-label extensions (All CZP)...
December 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29229474/accuracy-of-a-new-algorithm-to-identify-asthma-copd-overlap-aco-patients-in-a-cohort-of-patients-with-chronic-obstructive-airway-disease
#10
Luis Pérez de Llano, Borja G Cosío, Marc Miravitlles, Vicente Plaza
OBJECTIVES: We aimed to characterize the clinical, functional and inflammatory features of patients diagnosed diagnosed with ACO according to a new algorithm and to compare them with those of other chronic obstructive airway disease (COAD) categories (asthma and COPD). METHODS: ACO was diagnosed in a cohort of COAD patients in those patients with COPD who were either diagnosed with current asthma or showed significant blood eosinophilia (≥300cells/μl) and/or a very positive bronchodilator response (>400ml and >15% in FEV1)...
December 9, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29108938/fractional-exhaled-nitric-oxide-as-a-predictor-of-response-to-inhaled-corticosteroids-in-patients-with-non-specific-respiratory-symptoms-and-insignificant-bronchodilator-reversibility-a-randomised-controlled-trial
#11
David B Price, Roland Buhl, Adrian Chan, Daryl Freeman, Elizabeth Gardener, Clifford Godley, Kevin Gruffydd-Jones, Lorcan McGarvey, Ken Ohta, Dermot Ryan, Jörgen Syk, Ngiap Chuan Tan, TzeLee Tan, Mike Thomas, Sen Yang, Priyanka Raju Konduru, Marcus Ngantcha, Martina Stagno d'Alcontres, Therese S Lapperre
BACKGROUND: Chronic non-specific respiratory symptoms are difficult to manage. This trial aimed to evaluate the association between baseline fractional exhaled nitric oxide (FeNO) and the response to inhaled corticosteroids in patients with non-specific respiratory symptoms. METHODS: In this double-blind randomised placebo-controlled trial, we enrolled undiagnosed patients, aged 18-80 years, with cough, wheeze, or dyspnoea and less than 20% bronchodilator reversibility across 26 primary care centres and hospitals in the UK and Singapore...
November 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29060142/classification-of-voluntary-coughs-applied-to-the-screening-of-respiratory-disease
#12
Christian Infante, Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher
Pulmonary and respiratory diseases (e.g. asthma, COPD, allergies, pneumonia, tuberculosis, etc.) represent a large proportion of the global disease burden, mortality, and disability. In this context of creating automated diagnostic tools, we explore how the analysis of voluntary cough sounds may be used to screen for pulmonary disease. As a clinical study, voluntary coughs were recorded using a custom mobile phone stethoscope from 54 patients, of which 7 had COPD, 15 had asthma, 11 had allergic rhinitis, 17 had both asthma and allergic rhinitis, and four had both COPD and allergic rhinitis...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29016794/epidemiology-of-chronic-respiratory-diseases-and-associated-factors-in-the-adult-italian-population
#13
Gianluigi Ferrante, Sandro Baldissera, Stefano Campostrini
Background: Detailed epidemiology of Chronic Respiratory Diseases (CRDs) and of their risk and protective factors is needed to plan preventive interventions to reduce the burden of CRDs on population health. This study determines the prevalence of doctor-diagnosed CRDs and its associated factors in the adult Italian population. Methods: Data was collected from adults participating in the ongoing cross-sectional Italian Behavioural Risk Factor Surveillance System (PASSI) between 2013 and 2015...
July 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28994143/correlates-of-physical-activity-among-depressed-older-people-in-six-low-income-and-middle-income-countries-a-community-based-cross-sectional-study
#14
Davy Vancampfort, Brendon Stubbs, Nicola Veronese, James Mugisha, Nathalie Swinnen, Ai Koyanagi
OBJECTIVE: Despite the benefits of physical activity (PA) in older people with depression, many do not comply with the International PA guidelines. Thus, we investigated what factors influence PA participation among 915 community-dwelling older adults (aged ≥65 years) with depression in 6 low-income and middle-income countries (LMICs). METHODS: Cross-sectional data were analyzed from the World Health Organization's Study on Global Ageing and Adult Health. The sample was restricted to those with DSM-IV depression or receiving depression treatment in the last 12 months...
October 10, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28971615/efficacy-safety-and-tolerability-of-once-daily-abediterol-in-patients-with-stable-persistent-asthma-a-phase-ii-randomized-7-day-crossover-study
#15
Jutta Beier, Rainard Fuhr, Beatriz Seoane, Eric Massana, Gonzalo de Miquel, Helena Pujol, Sandrine Ruiz
Abediterol is a once-daily, long-acting β2 -adrenergic agonist in development for the treatment of asthma and chronic obstructive pulmonary disease. We assessed the efficacy, safety, and tolerability of three dose levels of abediterol, given once daily for 7 days in patients with stable, persistent asthma. This was an ascending-dose, three-period incomplete crossover study design investigating three dose levels of abediterol versus placebo (EudraCT No. 2008-003732-38). Twenty-eight male patients (25-59 years) were randomized to one of four treatment sequences (1:1:1:1)...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28947230/indications-risk-factors-and-outcomes-of-30-day-readmission-after-infrarenal-abdominal-aneurysm-repair
#16
Hanaa N Dakour Aridi, Satinderjit Locham, Besma Nejim, Nasr S Ghajar, Husain Alshaikh, Mahmoud B Malas
OBJECTIVE: Reducing readmissions is an important target for improving patient care and enhancing health care quality and cost-effectiveness. The aim of this study was to assess rates, risk factors, and indications of 30-day readmission after open aortic repair (OAR) and endovascular aneurysm repair (EVAR) of infrarenal abdominal aortic aneurysms (AAAs). METHODS: A retrospective analysis of the Premier Healthcare Database from 2009 to 2015 was performed. Indications for readmission after the index procedure, risk factors, and outcomes of the index admission and rehospitalization were evaluated...
September 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28947022/the-effect-of-umeclidinium-on-lung-function-and-symptoms-in-patients-with-fixed-airflow-obstruction-and-reversibility-to-salbutamol-a-randomised-3-phase-study
#17
Laurie Lee, Edward Kerwin, Kathryn Collison, Linda Nelsen, Wei Wu, Shuying Yang, Steven Pascoe
INTRODUCTION: The long-acting muscarinic antagonist, umeclidinium (UMEC), combined with the inhaled corticosteroid, fluticasone furoate (FF), improves lung function in symptomatic patients with asthma. We assessed FF/UMEC in patients with a primary diagnosis of asthma or chronic obstructive pulmonary disease (COPD), but physiological characteristics of both (fixed airflow obstruction and reversibility to salbutamol). METHODS: This double-blind, parallel-arm, 3-phase study randomised 338 patients (1:1:1:1:2:2) to FF 100 mcg alone or combined with UMEC (15...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28942872/association-of-sst2-and-hs-crp-levels-with-new-onset-atrial-fibrillation-in-coronary-artery-disease
#18
Santeri Nortamo, Olavi Ukkola, Samuli Lepojärvi, Tuomas Kenttä, Antti Kiviniemi, Juhani Junttila, Heikki Huikuri, Juha Perkiömäki
BACKGROUND: The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited. METHODS: A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28929036/factors-affecting-length-of-stay-following-elective-anterior-and-posterior-cervical-spine-surgery
#19
Frank J Yuk, Akbar Y Maniya, Jonathan J Rasouli, Alexa M Dessy, Patrick J McCormick, Tanvir F Choudhri
Background Disease of the cervical spine is widely prevalent, most commonly secondary to degenerative disc changes and spondylosis. Objective The goal of the paper was to identify a possible discrepancy regarding the length of stay (LOS) between the anterior and posterior approaches to elective cervical spine surgery and identify contributing factors. Methods A retrospective study was performed on 587 patients (341 anterior, 246 posterior) that underwent elective cervical spinal surgery between October 2001 and March 2014...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28917949/linear-association-between-number-of-modifiable-risk-factors-and-multiple-chronic-conditions-results-from-the-behavioral-risk-factor-surveillance-system
#20
Mary L Adams, Joseph Grandpre, David L Katz, Douglas Shenson
Multiple (≥2) chronic conditions (MCCs) are responsible for a large fraction of healthcare costs. Our aim was to examine possible associations between MCCs and composite measures of behavioral risk factors (RFs). Data were publicly available 2013 Behavioral Risk Factor Surveillance System and included 483,865 non-institutionalized US adults ages ≥18years. Chronic conditions included asthma, arthritis, chronic obstructive pulmonary disease, cognitive impairment, heart disease, stroke, cancer, and kidney disease...
December 2017: Preventive Medicine
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