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asthma vs copd

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https://www.readbyqxmd.com/read/29108938/fractional-exhaled-nitric-oxide-as-a-predictor-of-response-to-inhaled-corticosteroids-in-patients-with-non-specific-respiratory-symptoms-and-insignificant-bronchodilator-reversibility-a-randomised-controlled-trial
#1
David B Price, Roland Buhl, Adrian Chan, Daryl Freeman, Elizabeth Gardener, Clifford Godley, Kevin Gruffydd-Jones, Lorcan McGarvey, Ken Ohta, Dermot Ryan, Jörgen Syk, Ngiap Chuan Tan, TzeLee Tan, Mike Thomas, Sen Yang, Priyanka Raju Konduru, Marcus Ngantcha, Martina Stagno d'Alcontres, Therese S Lapperre
BACKGROUND: Chronic non-specific respiratory symptoms are difficult to manage. This trial aimed to evaluate the association between baseline fractional exhaled nitric oxide (FeNO) and the response to inhaled corticosteroids in patients with non-specific respiratory symptoms. METHODS: In this double-blind randomised placebo-controlled trial, we enrolled undiagnosed patients, aged 18-80 years, with cough, wheeze, or dyspnoea and less than 20% bronchodilator reversibility across 26 primary care centres and hospitals in the UK and Singapore...
November 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29060142/classification-of-voluntary-coughs-applied-to-the-screening-of-respiratory-disease
#2
Christian Infante, Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher
Pulmonary and respiratory diseases (e.g. asthma, COPD, allergies, pneumonia, tuberculosis, etc.) represent a large proportion of the global disease burden, mortality, and disability. In this context of creating automated diagnostic tools, we explore how the analysis of voluntary cough sounds may be used to screen for pulmonary disease. As a clinical study, voluntary coughs were recorded using a custom mobile phone stethoscope from 54 patients, of which 7 had COPD, 15 had asthma, 11 had allergic rhinitis, 17 had both asthma and allergic rhinitis, and four had both COPD and allergic rhinitis...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29016794/epidemiology-of-chronic-respiratory-diseases-and-associated-factors-in-the-adult-italian-population
#3
Gianluigi Ferrante, Sandro Baldissera, Stefano Campostrini
Background: Detailed epidemiology of Chronic Respiratory Diseases (CRDs) and of their risk and protective factors is needed to plan preventive interventions to reduce the burden of CRDs on population health. This study determines the prevalence of doctor-diagnosed CRDs and its associated factors in the adult Italian population. Methods: Data was collected from adults participating in the ongoing cross-sectional Italian Behavioural Risk Factor Surveillance System (PASSI) between 2013 and 2015...
July 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28994143/correlates-of-physical-activity-among-depressed-older-people-in-six-low-income-and-middle-income-countries-a-community-based-cross-sectional-study
#4
Davy Vancampfort, Brendon Stubbs, Nicola Veronese, James Mugisha, Nathalie Swinnen, Ai Koyanagi
OBJECTIVE: Despite the benefits of physical activity (PA) in older people with depression, many do not comply with the International PA guidelines. Thus, we investigated what factors influence PA participation among 915 community-dwelling older adults (aged ≥65 years) with depression in 6 low-income and middle-income countries (LMICs). METHODS: Cross-sectional data were analyzed from the World Health Organization's Study on Global Ageing and Adult Health. The sample was restricted to those with DSM-IV depression or receiving depression treatment in the last 12 months...
October 10, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28971615/efficacy-safety-and-tolerability-of-once-daily-abediterol-in-patients-with-stable-persistent-asthma-a-phase-ii-randomized-7-day-crossover-study
#5
Jutta Beier, Rainard Fuhr, Beatriz Seoane, Eric Massana, Gonzalo de Miquel, Helena Pujol, Sandrine Ruiz
Abediterol is a once-daily, long-acting β2 -adrenergic agonist in development for the treatment of asthma and chronic obstructive pulmonary disease. We assessed the efficacy, safety, and tolerability of three dose levels of abediterol, given once daily for 7 days in patients with stable, persistent asthma. This was an ascending-dose, three-period incomplete crossover study design investigating three dose levels of abediterol versus placebo (EudraCT No. 2008-003732-38). Twenty-eight male patients (25-59 years) were randomized to one of four treatment sequences (1:1:1:1)...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28947230/indications-risk-factors-and-outcomes-of-30-day-readmission-after-infrarenal-abdominal-aneurysm-repair
#6
Hanaa N Dakour Aridi, Satinderjit Locham, Besma Nejim, Nasr S Ghajar, Husain Alshaikh, Mahmoud B Malas
OBJECTIVE: Reducing readmissions is an important target for improving patient care and enhancing health care quality and cost-effectiveness. The aim of this study was to assess rates, risk factors, and indications of 30-day readmission after open aortic repair (OAR) and endovascular aneurysm repair (EVAR) of infrarenal abdominal aortic aneurysms (AAAs). METHODS: A retrospective analysis of the Premier Healthcare Database from 2009 to 2015 was performed. Indications for readmission after the index procedure, risk factors, and outcomes of the index admission and rehospitalization were evaluated...
September 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28947022/the-effect-of-umeclidinium-on-lung-function-and-symptoms-in-patients-with-fixed-airflow-obstruction-and-reversibility-to-salbutamol-a-randomised-3-phase-study
#7
Laurie Lee, Edward Kerwin, Kathryn Collison, Linda Nelsen, Wei Wu, Shuying Yang, Steven Pascoe
INTRODUCTION: The long-acting muscarinic antagonist, umeclidinium (UMEC), combined with the inhaled corticosteroid, fluticasone furoate (FF), improves lung function in symptomatic patients with asthma. We assessed FF/UMEC in patients with a primary diagnosis of asthma or chronic obstructive pulmonary disease (COPD), but physiological characteristics of both (fixed airflow obstruction and reversibility to salbutamol). METHODS: This double-blind, parallel-arm, 3-phase study randomised 338 patients (1:1:1:1:2:2) to FF 100 mcg alone or combined with UMEC (15...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28942872/association-of-sst2-and-hs-crp-levels-with-new-onset-atrial-fibrillation-in-coronary-artery-disease
#8
Santeri Nortamo, Olavi Ukkola, Samuli Lepojärvi, Tuomas Kenttä, Antti Kiviniemi, Juhani Junttila, Heikki Huikuri, Juha Perkiömäki
BACKGROUND: The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited. METHODS: A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28929036/factors-affecting-length-of-stay-following-elective-anterior-and-posterior-cervical-spine-surgery
#9
Frank J Yuk, Akbar Y Maniya, Jonathan J Rasouli, Alexa M Dessy, Patrick J McCormick, Tanvir F Choudhri
Background Disease of the cervical spine is widely prevalent, most commonly secondary to degenerative disc changes and spondylosis. Objective The goal of the paper was to identify a possible discrepancy regarding the length of stay (LOS) between the anterior and posterior approaches to elective cervical spine surgery and identify contributing factors. Methods A retrospective study was performed on 587 patients (341 anterior, 246 posterior) that underwent elective cervical spinal surgery between October 2001 and March 2014...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28917949/linear-association-between-number-of-modifiable-risk-factors-and-multiple-chronic-conditions-results-from-the-behavioral-risk-factor-surveillance-system
#10
Mary L Adams, Joseph Grandpre, David L Katz, Douglas Shenson
Multiple (≥2) chronic conditions (MCCs) are responsible for a large fraction of healthcare costs. Our aim was to examine possible associations between MCCs and composite measures of behavioral risk factors (RFs). Data were publicly available 2013 Behavioral Risk Factor Surveillance System and included 483,865 non-institutionalized US adults ages ≥18years. Chronic conditions included asthma, arthritis, chronic obstructive pulmonary disease, cognitive impairment, heart disease, stroke, cancer, and kidney disease...
December 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28845528/nutrient-intake-and-urinary-incontinence-in-korean-women-a-propensity-score-matched-analysis-from-the-korea-national-health-and-nutrition-examination-survey-data
#11
Jun Ho Lee, Hyo Serk Lee
OBJECTIVES: To evaluate the relationship between dietary nutrients and female urinary incontinence using nationally representative data from Korea. METHODS: We included 8090 women aged >20 years who had participated in the Korea National Health and Nutrition Examination Survey IV. We carried out a propensity-matched study by identifying women with urinary incontinence. Women without urinary incontinence, matched for age, body mass index, menopause, delivery history, hypertension, diabetes, hypercholesterolemia, stroke, asthma, chronic obstructive pulmonary disease and amount of total food intake, were included as a control group at a 2:1 ratio (661 women with urinary incontinence; 1322 women without urinary incontinence)...
November 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28822449/-cytokine-profiles-of-cd4-t-memory-cells-in-asthma-and-their-relationship-with-asthma-severity
#12
C L Du, K Xu, Z H Min, D D Li, H L Yuan, C Liu, Z H Chen
Objective: To study the phenotype of memory CD4(+) T cells in peripheral blood of asthmatics and its relationship with asthma severity. Methods: From Dec 2014 to Aug 2015, thirty-three asthmatics, twenty-six chronic obstructive pulmonary disease (COPD) patients and twenty-two healthy volunteers were enrolled in Respiratory Clinics of Zhongshan Hospital, Fudan University. Peripheral blood mononuclear cells (PBMCs) were isolated from peripheral blood. Cell surface markers (CD45RO, CRTH2, CD62L, and CCR7) and intracellular protein[interleukin (IL)-5, IL-17, interferon (IFN)-γ]staining was performed using flow-cytometric techniques...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28791839/a-comparative-study-of-strem-1-il-6-and-il-13-concentration-in-bronchoalveolar-lavage-fluid-in-asthma-and-copd-a-preliminary-study
#13
COMPARATIVE STUDY
Małgorzata Proboszcz, Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Katarzyna Górska, Rafał Krenke
BACKGROUND: Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a cell-surface receptor presented on neutrophils, macrophages and monocytes. Elevated sTREM-1 levels are a marker of acute microbial infections, and have also been reported in chronic lung diseases. IL-6 and IL-13 are effective markers in distinguishing these diseases. IL-6 has been shown to play an important role in chronic obstructive pulmonary disease (COPD), while IL-13 is described as one of the key mediators of allergic asthma...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28774201/patterns-of-use-of-dry-powder-inhalers-versus-pressurized-metered-dose-inhalers-devices-in-adult-patients-with-chronic-obstructive-pulmonary-disease-or-asthma-an-observational-comparative-study
#14
Wijdan H Ramadan, Aline T Sarkis
Numerous patients with chronic obstructive pulmonary disease (COPD) and asthma do not use inhaler devices properly, which can contribute to poor disease control. The objective of this study is to assess the technical and safety use of dry powder inhalers (DPIs) versus pressurized metered-dose inhalers (MDIs) in adult patients with COPD or asthma in Lebanon. A concurrent, prospective comparative observational study was conducted at one hospital and 15 community pharmacies in Lebanon. Over a period of 18 months, 246 questionnaires were filled...
August 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28694692/health-resource-utilization-for-inpatients-with-copd-treated-with-nebulized-arformoterol-or-nebulized-formoterol
#15
Vaidyanathan Ganapathy, Michael D Stensland
OBJECTIVE: Arformoterol is the (R,R)-enantiomer of formoterol. Preclinical studies suggest that it is a stronger bronchodilator than the racemic (R,R/S,S)-formoterol; however, its potential clinical advantages have not been demonstrated. This study compared the length of stay (LOS), 30-day readmission rates, and doses of rescue medication administered in hospitalized patients with COPD who were treated with nebulized arformoterol or nebulized formoterol. METHODS: This retrospective analysis utilized data from Premier, Inc...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28665552/comorbidities-in-adults-with-asthma-population-based-cross-sectional-analysis-of-1-4-million-adults-in-scotland
#16
C J Weatherburn, B Guthrie, S W Mercer, D R Morales
BACKGROUND: Comorbidity in people with asthma can significantly increase asthma morbidity and lower adherence to asthma guidelines. OBJECTIVE: The objective of this study was to comprehensively measure the prevalence of physical and mental health comorbidities in adults with asthma using a large nationally representative population. METHODS: Cross-sectional analysis of routine primary care electronic medical records for 1 424 378 adults in the UK, examining the prevalence of 39 comorbidities in people with and without asthma, before and after adjustment for age, sex, social deprivation and smoking status using logistic regression...
June 30, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28663549/determinants-of-initial-inhaled-corticosteroid-use-in-patients-with-gold-a-b-copd-a-retrospective-study-of-uk-general-practice
#17
James D Chalmers, Abigail Tebboth, Alicia Gayle, Andrew Ternouth, Nick Ramscar
Initial use of inhaled corticosteroid therapy is common in patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) A or B chronic obstructive pulmonary disease, contrary to GOLD guidelines. We investigated UK prescribing of inhaled corticosteroid therapy in these patients, to identify predictors of inhaled corticosteroid use in newly diagnosed chronic obstructive pulmonary disease patients. A cohort of newly diagnosed GOLD A/B chronic obstructive pulmonary disease patients was identified from the UK Clinical Practice Research Datalink (June 2005-June 2015)...
June 29, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28658726/-prevalence-of-vitamin-d-insufficiency-and-deficiency-in-mexican-adults-with-allergic-asthma
#18
Martín Bedolla-Barajas, Juan Carlos López-Hernández, Lourdes Fabiola García-Padilla, Jaime Morales-Romero, Fernando Antonio Velarde-Rivera, Martín Robles-Figueroa, José Raúl Ortiz-Peregrina
BACKGROUND: Hypovitaminosis D has been associated with various chronic diseases such as infections, autoimmune diseases, chronic obstructive pulmonary disease, cancer and asthma Objective: The objective at hand is to determine the prevalence of vitamin D (VD) insufficiency and deficiency in adults with allergic asthma. OBJECTIVE: Objective: The objective at hand is to determine the prevalence of vitamin D (VD) insufficiency and deficiency in adults with allergic asthma...
April 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28652722/pulmonary-rehabilitation-in-copd-available-resources-and-utilization-in-swedish-primary-and-secondary-care
#19
Josefin Sundh, Helena Lindgren, Mikael Hasselgren, Scott Montgomery, Christer Janson, Björn Ställberg, Karin Lisspers
INTRODUCTION: Pulmonary rehabilitation is effective in all stages of COPD. The availability and utilization of pulmonary rehabilitation resources, and the characteristics of COPD patients receiving rehabilitation, were investigated in primary and secondary care in central Sweden. MATERIALS AND METHODS: Data on available pulmonary rehabilitation resources were collected using questionnaires, to 14 hospitals and 54 primary health care centers, and information on utilization of different rehabilitation professionals was obtained from questionnaires completed by 1,329 COPD patients from the same centers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28585921/detection-of-lung-cancer-in-exhaled-breath-with-electronic-nose-using-support-vector-machine-analysis
#20
Madara Tirzīte, Māris Bukovskis, Gunta Strazda, Normunds Jurka, Immanuels Taivans
Lung cancer is one of the most common malignancies with a low five-year survival rate. There are no cheap, simple and widely available screening methods for early diagnostics of lung cancer. The aim of the study was to determine whether analysis of the exhaled breath with an artificial olfactory sensor using support vector analysis can differentiate lung cancer patients from healthy individuals and patients with other lung diseases regardless of the stage of lung cancer and the most common comorbidities...
June 6, 2017: Journal of Breath Research
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