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REVIEW
Octavian C Ioachimescu
In the general population, Bronchial Asthma (BA) and Obstructive Sleep Apnea (OSA) are amongst the most prevalent chronic respiratory disorders. Significant epidemiologic connections and complex pathogenetic pathways link these disorders via complex interactions at genetic, epigenetic and environmental levels. The coexistence of BA and OSA in an individual likely represents a distinct syndrome, i.e., a collection of clinical manifestations attributable to several mechanisms and pathobiological signatures. To avoid terminological confusion, this association has been named alternative overlap syndrome (vs overlap syndrome represented by the chronic obstructive pulmonary disease - OSA association)...
May 7, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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JOURNAL ARTICLE
Hassan Ashktorab, Antonio Pizuorno, Lakshmi Gayathri Chirumamilla, Folake Adeleye, Maryam Mehdipour Dalivand, Zaki A Sherif, Gholamreza Oskrochi, Suryanarayana Reddy Challa, Boubini Jones-Wonni, Sheldon Rankine, Chiamaka Ekwunazu, Abigail Banson, Rachel Kim, Chandler Gilliard, Elizabeth Ekpe, Nader Shayegh, Constance Nyaunu, Chidi Martins, Ashley Slack, Princess Okwesili, Malachi Abebe, Yashvardhan Batta, Do Ly, Ogwo Valarie, Tori Smith, Kyra Watson, Oluwapelumi Kolawole, Sarine Tahmazian, Sofiat Atoba, Myra Khushbakht, Gregory Riley, Warren Gavin, Areeba Kara, Manuel Hache-Marliere, Leonidas Palaiodimos, Vishnu R Mani, Aleksandr Kalabin, Vijay Reddy Gayam, Pavani Reddy Garlapati, Joseph Miller, Fatimah Jackson, John M Carethers, Vinod Rustgi, Hassan Brim
BACKGROUND AND AIM: Identifying clinical characteristics and outcomes of different ethnicities in the US may inform treatment for hospitalized COVID-19 patients. Aim of this study is to identify predictors of mortality among US races/ethnicities. DESIGN SETTING AND PARTICIPANTS: We retrospectively analyzed de-identified data from 9,873 COVID-19 patients who were hospitalized at 15 US hospital centers in 11 states (March 2020-November 2020). Main Outcomes and Measures: The primary outcome was to identify predictors of mortality in hospitalized COVID-19 patients...
2024: Arch Intern Med Res
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MULTICENTER STUDY
Gülfem Elif Çelik, Ömür Aydin, Elif Şen, Tunçalp Demir, Bilun Gemicioğlu, Esen Kiyan, Dilşad Mungan, İpek Kivilcim Oğuzülgen, Mehmet Polatli, Özlem Göksel, Abdullah Sayiner, Nurhayat Yildirim, Füsun Yildiz, Arzu Yorgancioğlu, Atilla Halil Elhan, Öznur Yildiz, İlknur Başyiğit, Şermin Börekçi, Yavuz Havlucu, Gülfer Okumuş, Murat Türk, Sevgi Saryal
INTRODUCTION: Patients with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) have a greater disease burden than those with COPD or asthma alone. In this study, it was aimed to determine the prevalence, risk factors, and clinical features of ACO because there are limited national data in Türkiye. MATERIALS AND METHODS: The study was conducted in a cross-sectional design in nine tertiary-care hospitals. The patients followed with a diagnosis of asthma or COPD for at least one year were enrolled in the study...
March 2024: Tüberküloz Ve Toraks
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JOURNAL ARTICLE
Qi Wei, Philip J Mease, Michael Chiorean, Lulu Iles-Shih, Wanessa F Matos, Andrew Baumgartner, Sevda Molani, Yeon Mi Hwang, Basazin Belhu, Alexandra Ralevski, Jennifer Hadlock
BACKGROUND: In the context of immune-mediated inflammatory diseases (IMIDs), COVID-19 outcomes are incompletely understood and vary considerably depending on the patient population studied. We aimed to analyse severe COVID-19 outcomes and to investigate the effects of the pandemic time period and the risks associated with individual IMIDs, classes of immunomodulatory medications (IMMs), chronic comorbidities, and COVID-19 vaccination status. METHODS: In this retrospective cohort study, clinical data were derived from the electronic health records of an integrated health-care system serving patients in 51 hospitals and 1085 clinics across seven US states (Providence St Joseph Health)...
May 2024: The Lancet. Digital health
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JOURNAL ARTICLE
François Rony, Mauro Cortellini, Alessandro Guasconi, Kusum S Mathews, Annalisa Piccinno, Gianluigi Poli, Frédéric Vanhoutte, Jelle Klein
INTRODUCTION: Use of propellants with high global warming potential (such as HFA-134a) for pressurised metered-dose inhalers (pMDIs) is being phased down. Switching to dry-powder inhalers may not be clinically feasible for all patients; an alternative is reformulation using propellants with low global warming potential. The combination of beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide (BDP/FF/GB) is available for asthma or chronic obstructive pulmonary disease via pMDI using HFA-134a as propellant...
April 23, 2024: Pulmonary Pharmacology & Therapeutics
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JOURNAL ARTICLE
Weiwei Meng, Ruoyan Xiong, Zhiqi Zhao, Huihui Zeng, Yan Chen
BACKGROUND: Inhaler concordance and the peak inspiratory flow rate (PIFR) are important determinants of treatment effects in patients with chronic airway diseases. Adequate PIFR is required for driving aerosol medication into the lower respiratory tract. However, the relationship between them has not been discussed previously. This study aimed to describe the characteristics of inhaler concordance and PIFR in Chinese patients with chronic airway diseases and discuss the associated variables and the relationship between them...
April 19, 2024: BMJ Open Respiratory Research
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JOURNAL ARTICLE
Parris Jade Williams, Leena Bachir, Keir Elmslie James Philip, Andrew Cumella, Mike Polkey, Anthony A Laverty, Nicholas S Hopkinson
BACKGROUND: Regular clinical reviews of people with COPD provide an opportunity to optimise management and are recommended in national and international guidelines. However, there are limited data about the relationship between having an annual review and other aspects of care quality, which might influence decision-making by healthcare professionals and commissioners. METHOD: Using data from 74 827 people with COPD completing the Asthma+Lung UK COPD Patient Passport, between 2014 and 2022, we conducted adjusted logistic regression (adjusting for year) and compared receipt of key items of care between those reporting that they had had an annual review (65...
April 10, 2024: BMJ Open
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REVIEW
Stefano Taddei, Nqoba Tsabedze, Ru-San Tan
β-blockers are a heterogeneous class, with individual agents distinguished by selectivity for β1 - vs. β2 - and α-adrenoceptors, presence or absence of partial agonist activity at one of more β-receptor subtype, presence or absence of additional vasodilatory properties, and lipophilicity, which determines the ease of entry the drug into the central nervous system. Cardioselectivity (β1 -adrenoceptor selectivity) helps to reduce the potential for adverse effects mediated by blockade of β2 -adrenoceptors outside the myocardium, such as cold extremities, erectile dysfunction, or exacerbation of asthma or chronic obstructive pulmonary disease...
2024: Current Medical Research and Opinion
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REVIEW
Hans-Peter Marti, Abel Alberto Pavía López, Pedro Schwartzmann
Cardioselective β-blockade is generally well tolerated in practice and contraindications to this therapy are uncommon. β-blockers are a diverse therapeutic class, and their individual tolerability profiles are influenced strongly by their pharmacodynamic effects across different adrenergic receptors. Bisoprolol, probably the β-blocker with the highest selectivity for blockade of β1 - vs. β2 -adrenoceptors, does not block β2 -adrenoceptors to an appreciable extent at doses in therapeutic use...
2024: Current Medical Research and Opinion
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JOURNAL ARTICLE
C Barrett Bowling, Richard A Faldowski, Richard Sloane, Carl Pieper, Tyson H Brown, Erin E Dooley, Brett T Burrows, Norrina B Allen, Kelley Pettee Gabriel, Cora E Lewis
BACKGROUND: Multimorbidity research has focused on the prevalence and consequences of multimorbidity in older populations. Less is known about the accumulation of chronic conditions earlier in the life course. METHODS: We identified patterns of longitudinal multimorbidity accumulation using 30 years of data from in-person exams, annual follow-ups, and adjudicated end-points among 4,945 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study...
2024: J Multimorb Comorb
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JOURNAL ARTICLE
Anna Eligulashvili, Megan Darrell, Moshe Gordon, William Jerome, Kevin P Fiori, Seth Congdon, Tim Q Duong
This study investigated long COVID of patients in the Montefiore Health System COVID-19 (CORE) Clinics in the Bronx with an emphasis on identifying health related social needs (HRSNs). We analyzed a cohort of 643 CORE patients (6/26/2020-2/24/2023) and 52,089 non-CORE COVID-19 patients. Outcomes included symptoms, physical, emotional, and cognitive function test scores obtained at least three months post-infection. Socioeconomic variables included median incomes, insurance status, and HRSNs. The CORE cohort was older age (53...
April 2, 2024: Scientific Reports
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JOURNAL ARTICLE
Zsófia Lázár, Alpár Horváth, Szilvia Kiss-Dala, Zsolt Abonyi-Tóth, Balázs Csoma, Katalin Kontz, Lilla Tamási, Veronika Müller
BACKGROUND: The criteria for significant bronchodilator responsiveness (BDR) were published in 2005 by the European Respiratory Society/American Thoracic Society, which were revised in 2021, however, data on the agreement between these two recommendations in untreated patients with airflow limitation are missing. AIMS: We aimed to study BDR to salbutamol (SABA) or ipratropium bromide (SAMA) in patients with suspected bronchial asthma or COPD at initial clinical presentation using the 2005 and 2021 criteria and explore clinical factors associated with BDR+...
2024: European Clinical Respiratory Journal
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JOURNAL ARTICLE
Maéva Zysman, Anaëlle Coquelin, Nelly Le Guen, Agnès Solomiac, Marina Guecamburu, Marie Erbault, Elodie Blanchard, Nicolas Roche, Sandrine Morin
INTRODUCTION: Despite concordant international recommendations, many surveys found disappointing rates of influenza vaccination in at-risk populations, ranging from 23% in overall COPD population to more than 70% in more severe COPD subjects. Therefore, we assessed the proportion of French COPD patients non-vaccinated for influenza and their clinical and socio-demographic factors. MATERIEL AND METHODS: This was a national retrospective study based on the French health insurance database...
March 22, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Serena Correnti, Mariaimmacolata Preianò, Fabia Gamboni, Daniel Stephenson, Corrado Pelaia, Girolamo Pelaia, Rocco Savino, Angelo D'Alessandro, Rosa Terracciano
BACKGROUND: Due to their complexity and to the presence of common clinical features, differentiation between asthma and chronic obstructive pulmonary disease (COPD) can be a challenging task, complicated in such cases also by asthma-COPD overlap syndrome. The distinct immune/inflammatory and structural substrates of COPD and asthma are responsible for significant differences in the responses to standard pharmacologic treatments. Therefore, an accurate diagnosis is of central relevance to assure the appropriate therapeutic intervention in order to achieve safe and effective patient care...
March 23, 2024: Journal of Translational Medicine
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JOURNAL ARTICLE
Bethany R Tellor Pennington, Katherine J Holzer, Bradley A Fritz, Simon Haroutounian, Kevin Y Xu, Amanda Tedder, Alex Kronzer, Michael S Avidan, Eric J Lenze
BACKGROUND: Older surgical patients with depression often experience poor postoperative outcomes. Poor outcomes may stem from brain-hazardous medications and subadequate antidepressant dosing. METHODS: This was a retrospective, observational cohort study covering the period between January 1, 2021 and December 31, 2021. Patients ≥60 years of age who underwent inpatient surgery and had an overnight stay at an integrated academic health care system comprising 14 hospitals were eligible...
March 18, 2024: Anesthesia and Analgesia
#16
JOURNAL ARTICLE
Timothy Howarth, Claire Gibbs, Subash S Heraganahally, Asanga Abeyaratne
BACKGROUND: This study assessed hospitalisation frequency and related clinical outcomes among adult Aboriginal Australians with bronchiectasis over a ten-year study period. METHOD: This retrospective study included patients aged ≥ 18 years diagnosed with bronchiectasis between 2011 and 2020 in the Top End, Northern Territory of Australia. Hospital admissions restricted to respiratory conditions (International Classification of Diseases (ICD) code J) and relevant clinical parameters were assessed and compared between those with and without hospital admissions...
March 6, 2024: BMC Pulmonary Medicine
#17
JOURNAL ARTICLE
Weiwei Meng, Zhiqi Zhao, Ruoyan Xiong, Yanjun Zhong, Huihui Zeng, Yan Chen
OBJECTIVES: Inhaler satisfaction is an important factor affecting inhaler adherence and the efficacy of inhalers in chronic airway diseases. Using a scientific and effective method to assess patients' satisfaction with inhalers is of great significance for improving clinical outcomes. The Feeling of Satisfaction with Inhaler-10 (FSI-10) is specifically designed to assess patients' inhaler satisfaction in chronic airway diseases, but the application research on this scale is not available in China...
December 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
#18
JOURNAL ARTICLE
Hicham Achebak, Grégoire Rey, Simon J Lloyd, Marcos Quijal-Zamorano, Raúl Fernando Méndez-Turrubiates, Joan Ballester
AIMS: We assessed the association of temperature and temperature variability with cause-specific emergency hospitalizations and mortality from cardiovascular and respiratory diseases in Spain, as well as the effect modification of this association by individual and contextual factors. METHODS AND RESULTS: We collected data on health (hospital admissions and mortality), weather (temperature and relative humidity), and relevant contextual indicators for 48 Spanish provinces during 2004-2019...
February 13, 2024: European Journal of Preventive Cardiology
#19
JOURNAL ARTICLE
Chen Liang, Hsin-Fang Chung, Annette Dobson, Sven Sandin, Elisabete Weiderpass, Gita D Mishra
BACKGROUND: Female reproductive factors may influence the development of chronic obstructive pulmonary disease (COPD) through the female hormonal environment, but studies on this topic are limited. This study aimed to assess whether age at menarche, number of children, infertility, miscarriage, stillbirth and age at natural menopause were associated with the risk of COPD. METHODS: Women from three cohorts with data on reproductive factors, COPD and covariates were included...
February 13, 2024: Thorax
#20
JOURNAL ARTICLE
Nadia Al Wachami, Maryem Arraji, Younes Iderdar, Yassmine Mourajid, Karima Boumendil, Fatima Zahra Bouchachi, Samira Jaouhar, Morad Guennouni, Fatimazahra Laamiri, Noureddine Elkhoudri, Lahcen Bandadi, Mohamed Lahbib Louerdi, Abderraouf Hilali, Mohamed Chahboune
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major public health problem. In Morocco, few studies have focused on COPD in primary health care facilities, whose main mission is prevention. The aim of our work is thus to assess the prevalence of COPD and to study the factors associated with this silent disease among users of health care facilities in Morocco. METHODS: This is a cross-sectional observational study of participants aged 40 and over. Data were collected by questionnaire...
2024: International Journal of Chronic Obstructive Pulmonary Disease
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