Pascale M Abena, Eric H Decloedt, Emmanuel Bottieau, Fatima Suleman, Prisca Adejumo, Nadia A Sam-Agudu, Jean-Jacques Muyembe TamFum, Moussa Seydi, Serge P Eholie, Edward J Mills, Oscar Kallay, Alimuddin Zumla, Jean B Nachega
The novel severe acute respiratory syndrome-coronavirus-2 pandemic has spread to Africa, where nearly all countries have reported laboratory-confirmed cases of novel coronavirus disease (COVID-19). Although there are ongoing clinical trials of repurposed and investigational antiviral and immune-based therapies, there are as yet no scientifically proven, clinically effective pharmacological treatments for COVID-19. Among the repurposed drugs, the commonly used antimalarials chloroquine (CQ) and hydroxychloroquine (HCQ) have become the focus of global scientific, media, and political attention despite a lack of randomized clinical trials supporting their efficacy...
June 2020: American Journal of Tropical Medicine and Hygiene