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segmental sensitization

Florian S M Edlinger, Laura M Schrems-Hoesl, Christian Y Mardin, Robert Laemmer, Friedrich E Kruse, Wolfgang A Schrems
PURPOSE: Assessment of the diagnostic ability of segmented macular inner retinal layer thickness and peripapillary retinal nerve fiber layer (pRNFL) measured by spectral-domain optical coherence tomography (SD-OCT) in patients with normal-tension (NT) and high-tension (HT) perimetric and preperimetric glaucoma. METHODS: The 212 participants included 45 healthy subjects, 55 patients with ocular hypertension, 56 patients with preperimetric glaucoma, and 56 patients with perimetric glaucoma...
March 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Qiumei Feng, Xiaolei Zhao, Yuehua Guo, Mingkai Liu, Po Wang
A target-driven stochastic DNA walking electrochemical biosensor sensitized with gold nanocages@graphene nanoribbons (Au NCs@GNRs) was explored for sensitive detection of target DNA. Benefited from the large surface area and excellent conductivity of Au NCs and GNRs, the proposed sensing platform not only improved the electron transfer kinetics involved in electrochemical reactions, but also enhanced the loading capability for stem-loop structural DNA segment (H). Upon the addition of target DNA, the hairpin structure of H was opened and H:target DNA duplex was formed based on toehold-mediated DNA strand displacement...
February 23, 2018: Biosensors & Bioelectronics
Christoph Braig, Ivo Zizak
We investigate the potential of large-scale diffractive-refractive normal-incidence transmission lenses for the development of space-based hard x-ray telescopes with an angular resolution in the range of (10-6 -10-3 )  arcsec over a field of view that is restricted by the available detector size. Coherently stepped achromatic lenses with diameters up to 5 m for compact apertures and 13 m in the case of segmentation provide an access to spectrally resolved imaging within keV-wide bands around the design energy between 10 and 30 keV...
March 10, 2018: Applied Optics
Søren Brandt Poulsen, Kavee Limbutara, Robert Andrew Fenton, Trairak Pisitkun, Birgitte M Christensen
The renal aldosterone-sensitive distal tubule (ASDT) is crucial for sodium reabsorption and blood pressure regulation. The ASDT consists of the late distal convoluted tubule (DCT2), connecting tubule (CNT) and collecting duct. Due to difficulties in isolating epithelial cells from the ASDT in large quantities, few transcriptome studies have been performed on this segment. Moreover, no studies exist on isolated DCT2 and CNT cells (excluding intercalated cells), and the role of aldosterone for regulating the transcriptome of these specific cell types is largely unknown...
March 9, 2018: Physiological Genomics
Jonathan R Young, Heidi Coy, Hyun J Kim, Michael Douek, Anthony Sisk, Arie Belldegrun, Allan J Pantuck, Steven S Raman
PURPOSE: To investigate if multiphasic multidetector computed tomography (MDCT) enhancement profiles can distinguish clear cell renal cell carcinomas (ccRCCs) with high carbonic anhydrase-IX (CA-IX) expression from ccRCCs with low CA-IX expression. METHODS: With IRB approval for this retrospective study, we derived a cohort of 105 histologically proven ccRCCs with preoperative 4-phase renal mass MDCT from 2001 to 2013. Following manual segmentation, the computer-assisted detection algorithm selected a 0...
March 8, 2018: Abdominal Radiology
Jing Gong, Ji-Yu Liu, Li-Jia Wang, Xi-Wen Sun, Bin Zheng, Sheng-Dong Nie
Computer-aided detection (CAD) technology has been developed and demonstrated its potential to assist radiologists in detecting pulmonary nodules especially at an early stage. In this paper, we present a novel scheme for automatic detection of pulmonary nodules in CT images based on a 3D tensor filtering algorithm and local image feature analysis. We first apply a series of preprocessing steps to segment the lung volume and generate the isotropic volumetric CT data. Next, a unique 3D tensor filtering approach and local image feature analysis are used to detect nodule candidates...
February 2018: Physica Medica: PM
Deepthi P Varikuti, Sarah Genon, Aristeidis Sotiras, Holger Schwender, Felix Hoffstaedter, Kaustubh R Patil, Christiane Jockwitz, Svenja Caspers, Susanne Moebus, Katrin Amunts, Christos Davatzikos, Simon B Eickhoff
The relationship between grey matter volume (GMV) patterns and age can be captured by multivariate pattern analysis, allowing prediction of individuals' age based on structural imaging. Raw data, voxel-wise GMV and non-sparse factorization (with Principal Component Analysis, PCA) show good performance but do not promote relatively localized brain components for post-hoc examinations. Here we evaluated a non-negative matrix factorization (NNMF) approach to provide a reduced, but also interpretable representation of GMV data in age prediction frameworks in healthy and clinical populations...
March 5, 2018: NeuroImage
Hong Luo, Jin Quan, He Xiao, Jia Luo, Qin Zhang, Guocheng Pi, Yunfei Ye, Rong He, Yun Liu, Xiaona Su, Lianhua Zhao, Ge Wang
Activation of fibroblast growth factor receptor (FGFR) signaling occurs in various cancers, including esophageal squamous cell carcinoma (ESCC), however, the effect of targeting FGFR in ESCC is not clear. Herein, we examined the phosphorylation level of FGFR1Y654 (p‑FGFR1) in ESCC cell lines and tumor tissues, as well as the cancer cell killing effects of gefitinib and FGFR inhibitor AZD4547 in combination form or alone in ESCC cells. Immunohistochemistry staining was used to detect the expression level of p‑FGFR1 in 87 ESCC specimens...
March 8, 2018: Oncology Reports
Li Wang, Min-Jie Lu, Lei Feng, Juan Wang, Wei Fang, Zuo-Xiang He, Ke-Fei Dou, Shi-Hua Zhao, Min-Fu Yang
BACKGROUND: The relationship between myocardial viability and angiographic collateral flow is not fully elucidated in ischemic cardiomyopathy (ICM) with coronary artery chronic total occlusion (CTO). We aimed to clarify the relationship between myocardial hibernation, myocardial scar, and angiographic collateral flow in these patients. METHODS AND RESULTS: Seventy-one consecutive ICM patients with 122 CTOs and 652 dysfunctional segments within CTO territories were retrospectively analyzed...
March 7, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Rashmi Panda, N B Puhan, Ganapati Panda
Accurate optic disc (OD) segmentation is an important step in obtaining cup-to-disc ratio-based glaucoma screening using fundus imaging. It is a challenging task because of the subtle OD boundary, blood vessel occlusion and intensity inhomogeneity. In this Letter, the authors propose an improved version of the random walk algorithm for OD segmentation to tackle such challenges. The algorithm incorporates the mean curvature and Gabor texture energy features to define the new composite weight function to compute the edge weights...
February 2018: Healthcare Technology Letters
Fumi Yanagisawa, Yasuo Amano, Masaki Tachi, Keisuke Inui, Kuniya Asai, Shinichiro Kumita
PURPOSE: We sought to use non-contrast-enhanced T1 mapping to determine the native T1 values required to identify myocardial fibrosis in patients with dilated cardiomyopathy (DCM). METHODS: A total of 25 patients with DCM and 15 healthy controls were enrolled. All subjects underwent T1 mapping using modified look-locker inversion recovery, and the patients underwent late gadolinium-enhancement (LGE) imaging. Basal and mid-ventricular levels were divided into eight segments and the T1 value was measured in each segment...
March 7, 2018: Magnetic Resonance in Medical Sciences: MRMS
John P Lichtenberger, Andrew M Kim, Dane Fisher, Peter S Tatum, Brian Neubauer, P Gabriel Peterson, Brett W Carter
Introduction: Combat-related thoracic trauma (CRTT) is a significant contributor to morbidity and mortality of the casualties from Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF). Penetrating, blunt, and blast injuries are the most common mechanisms of trauma to the chest. Imaging plays a key role in the battlefield management of CRTT casualties. This work discusses the imaging manifestations of thoracic injuries from blunt trauma and blast injury, emphasizing epidemiology and diagnostic clues seen during OEF and OIF...
March 1, 2018: Military Medicine
Natally Horvat, Harini Veeraraghavan, Monika Khan, Ivana Blazic, Junting Zheng, Marinela Capanu, Evis Sala, Julio Garcia-Aguilar, Marc J Gollub, Iva Petkovska
Purpose To investigate the value of T2-weighted-based radiomics compared with qualitative assessment at T2-weighted imaging and diffusion-weighted (DW) imaging for diagnosis of clinical complete response in patients with rectal cancer after neoadjuvant chemotherapy-radiation therapy (CRT). Materials and Methods This retrospective study included 114 patients with rectal cancer who underwent magnetic resonance (MR) imaging after CRT between March 2012 and February 2016. Median age among women (47 of 114, 41%) was 55...
March 7, 2018: Radiology
Taiki Kokubun, Satoru Tsuda, Hiroshi Kunikata, Noriko Himori, Yu Yokoyama, Shiho Kunimatsu-Sanuki, Toru Nakazawa
PURPOSE: To determine whether anterior-segment optical coherence tomography (AS-OCT) can be used to predict post-trabeculectomy bleb outcomes. MATERIALS AND METHODS: We divided 58 eyes of 47 trabeculectomy patients into success or failure groups based on their status at 12 months after surgery. We then compared various AS-OCT measurement parameters between the two groups at 1 and 2 weeks and 1, 3, 6, and 12 months. We also analyzed the early post-trabeculectomy bleb parameters with multiple logistic regression, stepwise multiple regression, and the receiver operating characteristic (ROC) curve, to evaluate the power of these parameters to predict long-term outcomes...
March 7, 2018: Current Eye Research
Salih Kilic, Umut Kocabas, Levent Hurkan Can, Oğuz Yavuzgil, Mustafa Çetin, Mehdi Zoghi
BACKGROUND: Thrombolytic therapy is recommended for patients with acute ST-segment elevation myocardial infarction (STEMI) who cannot undergo primary percutaneous coronary intervention within the first 120 min. The aim of this study wasz to demonstrate the value of CHA₂DS₂-VASc and CHA₂DS₂-VASc-HS scores in predicting failed reperfusion in STEMI patients treated with thrombolytic therapy. METHODS: A total of 537 consecutive patients were enrolled in the study; 139 had failed thrombolysis while the remaining 398 fulfilled the criteria for successful thrombolysis...
March 7, 2018: Cardiology Journal
Heba Mostafa Ahmed, Dina Ahmed Ezzat, Noha A Doudar, Mai Adel
INTRODUCTION: Early diagnosis of minimal change disease (MCD) is challenging in nephrotic children. CD80 is a protein expressed on the surface of podocytes associated with nephrotic syndrome and it is implicated in the induction of proteinuria. This study aimed to investigate the use of urinary CD80 for the diagnosis of MCD. MATERIALS AND METHODS: Urinary CD80 levels were evaluated in 36 children with nephrotic syndrome and normal glomerular filtration rate. They were divided into three groups of MCD (n = 21), focal segmental glomerulosclerosis (n = 9), and other glomerulopathies (n = 6)...
March 2018: Iranian Journal of Kidney Diseases
Daniele Andreini, Saima Mushtaq, Gianluca Pontone, Edoardo Conte, Marco Guglielmo, Andrea Annoni, Andrea Baggiano, Alberto Formenti, Valentina Ditali, Maria Elisabetta Mancini, Simone Zanchi, Eleonora Melotti, Daniela Trabattoni, Piero Montorsi, Paolo Mario Ravagnani, Cesare Fiorentini, Antonio L Bartorelli, Mauro Pepi
BACKGROUND: Aim of the study was to evaluate image quality, radiation exposure and diagnostic accuracy of coronary CT angiography (CCTA) performed with a novel cardiac CT scanner in patients with very high heart rate (HR). METHODS: We prospectively enrolled 202 patients (111 men, mean age 66±8years) with suspected coronary artery disease who underwent CCTA with a whole-organ volumetric CT scanner. The HR during the scan was ≥80bpm in 100 patients (Group 1), while it was ≤65bpm in the remaining 102 patients (Group 2)...
April 15, 2018: International Journal of Cardiology
Alberto Cappelletti, Domenico Astore, Cosmo Godino, Barbara Bellini, Valeria Magni, Monica Mazzavillani, Matteo Pagnesi, Eustachio Agricola, Roberto Chiesa, Antonio Colombo, Alberto Margonato
BACKGROUND: Data concerning the relationship between cardiovascular risk factors, plasmatic markers, carotid disease and extent of coronary lesions are lacking. OBJECTIVES: To evaluate the role of cardiovascular risk factors, plasmatic levels of high sensitivity C-reactive protein (hs-CRP), fibrinogen, lipoprotein(a), and carotid plaque extension in predicting the severity of coronary artery disease (CAD). METHODS: We analyzed 574 subjects undergoing first coronary angiography...
April 15, 2018: International Journal of Cardiology
Berthold Pemp, Stefan Palkovits, Kinga Howorka, Jiri Pumprla, Stefan Sacu, Gerhard Garhöfer, Michaela Bayerle-Eder, Leopold Schmetterer, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR). METHODS: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation...
March 5, 2018: Acta Ophthalmologica
Michelle M Mello, Julia Adler-Milstein, Karen L Ding, Lucia Savage
Policy Points: Historically, in addition to economic and technical hurdles, state and federal health information privacy laws have been cited as a significant obstacle to expanding electronic health information exchange (HIE) in the United States. Our review finds that over the past decade, several helpful developments have ameliorated the legal barriers to HIE, although variation in states' patient consent requirements remains a challenge. Today, health care providers' complaints about legal obstacles to HIE may be better understood as reflecting concerns about the economic and competitive risks of information sharing...
March 2018: Milbank Quarterly
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