Hui Shi, Qian-Ying Li, Hui Li, Hai-Yan Wang, Chuan-Xi Fan, Qiao-Yan Dong, Bo-Chen Pan, Zhi-Liang Ji, Jian-Yuan Li
STUDY QUESTION: What is the mechanism behind cryoinjury in human sperm, particularly concerning the interplay between reactive oxygen species (ROS) and autophagy, and how does it subsequently affect sperm fate? SUMMARY ANSWER: The freeze-thaw operation induces oxidative stress by generating abundant ROS, which impairs sperm motility and activates autophagy, ultimately guiding the sperm toward programmed cell death such as apoptosis and necrosis, as well as triggering premature capacitation...
February 1, 2024: Human Reproduction