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https://www.readbyqxmd.com/read/28571827/effect-on-overall-survival-of-locoregional-treatment-in-a-cohort-of-de-novo-metastatic-prostate-cancer-patients-a-single-institution-retrospective-analysis-from-the-royal-marsden-hospital
#1
Diletta Bianchini, David Lorente, Pasquale Rescigno, Zafeiris Zafeiriou, Elena Psychopaida, Hazel O'Sullivan, Mervyn Alaras, Michael Kolinsky, Semini Sumanasuriya, Mariane Sousa Fontes, Joaquin Mateo, Raquel Perez Lopez, Nina Tunariu, Nikolaos Fotiadis, Pardeep Kumar, Alison Tree, Nicholas Van As, Vincent Khoo, Chris Parker, Rosalind Eeles, Alan Thompson, David Dearnaley, Johann S de Bono
BACKGROUND: The optimal management of the primary tumor in metastatic at diagnosis (M1) prostate cancer (PCa) patients is not yet established. We retrospectively evaluated the effect of locoregional treatment (LRT) on overall survival (OS) hypothesizing that this could improve outcome through better local disease control and the induction of an antitumor immune response (abscopal effect). PATIENTS AND METHODS: M1 at diagnosis PCa patients referred to the Prostate Targeted Therapy Group at the Royal Marsden between June 2003 and December 2013 were identified...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28567503/planning-benchmark-study-for-sbrt-of-early-stage-nsclc-results-of-the-degro-working-group-stereotactic-radiotherapy
#2
Christos Moustakis, Oliver Blanck, Fatemeh Ebrahimi Tazehmahalleh, Mark Ka Heng Chan, Iris Ernst, Thomas Krieger, Marciana-Nona Duma, Markus Oechsner, Ute Ganswindt, Christian Heinz, Horst Alheit, Hilbert Blank, Ursula Nestle, Rolf Wiehle, Christine Kornhuber, Christian Ostheimer, Cordula Petersen, Gerhard Pollul, Wolfgang Baus, Georg Altenstein, Eric Beckers, Katrin Jurianz, Florian Sterzing, Matthias Kretschmer, Heinrich Seegenschmiedt, Torsten Maass, Stefan Droege, Ulrich Wolf, Juergen Schoeffler, Uwe Haverkamp, Hans Theodor Eich, Matthias Guckenberger
PURPOSE: The aim was to evaluate stereotactic body radiation therapy (SBRT) treatment planning variability for early stage nonsmall cell lung cancer (NSCLC) with respect to the published guidelines of the Stereotactic Radiotherapy Working Group of the German Society for Radiation Oncology (DEGRO). MATERIALS AND METHODS: Planning computed tomography (CT) scan and the structure sets (planning target volume, PTV; organs at risk, OARs) of 3 patients with early stage NSCLC were sent to 22 radiotherapy departments with SBRT experience: each department was asked to prepare a treatment plan according to the DEGRO guidelines...
May 31, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28506649/dose-optimization-in-cardiac-ct
#3
REVIEW
Sandeep Hedgire, Brian Ghoshhajra, Mannudeep Kalra
Rapid progress in the field of Cardiac CT is fostered by the advances in CT scanner technology as well as multiple clinical trials demonstrating its role in coronary artery disease and other indications like congenital heart disease, pulmonary vein assessment and pre transcatheter aortic valve replacement. The cardiovascular imager today is responsible for delivering diagnostic image quality while striking a balance with optimized radiation dose. Radiation dose is the result of multiple scanner and patient related factors...
May 12, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28490467/dose-optimization-to-minimize-radiation-risk-for-children-undergoing-ct-and-nuclear-medicine-imaging-is-misguided-and-detrimental
#4
Jeffry A Siegel, Bill Sacks, Charles W Pennington, James S Welsh
A debate exists within the medical community on whether the linear no-threshold model of ionizing radiation exposure accurately predicts the subsequent incidence of radiogenic cancer. In this article, we evaluate evidence refuting the linear no-threshold model and corollary efforts to reduce radiation exposure from CT and nuclear medicine imaging in accord with the as-low-as-reasonably-achievable principle, particularly for children. Further, we review studies demonstrating that children are not, in fact, more radiosensitive than adults in the radiologic imaging dose range, rendering dose reduction for children unjustifiable and counterproductive...
June 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28483219/laryngotracheal-anomalies-and-airway-fluoroscopy-in-infants
#5
Amal Isaiah, Kevin D Pereira
OBJECTIVES: The role of airway fluoroscopy in the diagnosis of laryngotracheal anomalies in infants is controversial. We aimed to (i) compare airway fluoroscopic characteristics with endoscopic findings in infants presenting for evaluation of upper airway obstruction and (ii) assess the as low as is reasonably achievable (ALARA) status for airway fluoroscopy as an initial diagnostic test in suspected laryngotracheal anomalies. MATERIALS AND METHODS: We performed a retrospective review of children who underwent fluoroscopy and endoscopic evaluation of the airway in the operating room for suspected laryngotracheal anatomic abnormalities...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28479456/contrast-induced-nephropathy-fact-or-fiction-in-lower-limb-revascularisation
#6
Carlos Martínez-Rico, Xavier Martí-Mestre, Antonio Romera-Villegas, Emma Espinar-Garcia, Elena Iborra-Ortega, Ramón Vila-Coll
INTRODUCTION: Contrast-induced nephropathy (CIN) is defined as a increase >25% of serum creatinine from baseline, occurring in 24-48 hours after exposure to contrast, while alternative explanations for renal impairment have been excluded. The volume administered directly relates to risk, increasing by 12% per 100ml of contrast. According to the series, its incidence varies between 3.3-8% in patients without renal damage and 12-50% in patients with chronic kidney disease (CKD) and/or diabetes mellitus (DM)...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28449852/radiation-exposure-during-intramedullary-nailing
#7
David J Hak
Surgeons should aim to keep radiation exposure "As Low As Reasonably Achievable (ALARA)" during intramedullary nailing and other minimally invasive surgical procedures. This requires understanding the principles of ionizing radiation and methods for minimizing exposure risk. The main source of radiation exposure to surgical personnel during fluoroscopy is from scattered radiation. Since radiation scatter is mainly directed towards the fluoroscopy source, the best configuration during surgery to reduce radiation dose to the surgeon is to position the fluoroscopic source below the operating room table and the image collector above the table...
April 24, 2017: Injury
https://www.readbyqxmd.com/read/28429301/ethical-issues-related-to-the-promotion-of-a-100-msv-threshold-assumption-in-japan-after-the-fukushima-nuclear-accident-in-2011-background-and-consequences
#8
REVIEW
Toshihide Tsuda, Lena Lindahl, Akiko Tokinobu
PURPOSE OF REVIEW: This article describes the debates in Japan regarding the 100 mSv threshold assumption and ethical issues related to it, and explores the background to distorted risk information and absence of risk communication in Japan. Then we seek proper risk communication based on scientific evidence. RECENT FINDINGS: On March 11, 2011 an accident occurred at the Fukushima Daiichi Nuclear Power Plant due to the Great East Japan Earthquake. Since then a number of misunderstandings have become common in Japan as a result of public statements by the Japanese and local governments that have no basis in medical science or are contradictory to medical science...
June 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28408700/contamination-a-major-problem-in-nuclear-medicine-imaging-how-to-investigate-handle-and-avoid-it
#9
Narvesh Kumar, Shashwat Verma, Rani Kunti Randhir Singh, Deepanksha Datta, Subhash Chand Kheruka, Sanjay Gambhir
We submitted this study to describe the pattern of contamination of the collimator and motion artifact, and measures needed for its identification and confirmation, to emphasise the importance of detection of potential sources of false positive results associated with the nuclear scans. It is important for the nuclear medicine technologist and physicians to recognize the various patterns of sources of error associated in a specific study in order to avoid the unnecessary radiation exposure to the patients (according to the ALARA)...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28323979/thyroid-cancer-following-childhood-low-dose-radiation-exposure-a-pooled-analysis-of-nine-cohorts
#10
Jay H Lubin, M Jacob Adams, Roy Shore, Erik Holmberg, Arthur B Schneider, Michael M Hawkins, Leslie L Robison, Peter D Inskip, Marie Lundell, Robert Johansson, Ruth A Kleinerman, Florent de Vathaire, Lena Damber, Siegal Sadetzki, Margaret Tucker, Ritsu Sakata, Lene H S Veiga
Context: The increased use of diagnostic and therapeutic procedures that involve radiation raises concerns about radiation effects, particularly in children and to the radio-sensitive thyroid gland. Objectives: Evaluation of relative risk (RR) trends for thyroid radiation doses <0.2 gray; evidence of a threshold dose; and possible modifiers of the dose-response, e.g., sex, age at exposure, time since exposure. Design and setting: Pooled data from nine cohort studies of childhood external radiation exposure and thyroid cancer with individualized dose estimates, ≥1,000 irradiated subjects or ≥10 thyroid cancer cases, with data limited to individuals receiving doses <0...
March 8, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28321175/evidence-that-lifelong-low-dose-rates-of-ionizing-radiation-increase-lifespan-in-long-and-short-lived-dogs
#11
Jerry M Cuttler, Ludwig E Feinendegen, Yehoshua Socol
After the 1956 radiation scare to stop weapons testing, studies focused on cancer induction by low-level radiation. Concern has shifted to protecting "radiation-sensitive individuals." Since longevity is a measure of health impact, this analysis reexamined data to compare the effect of dose rate on the lifespans of short-lived (5% and 10% mortality) dogs and on the lifespans of dogs at 50% mortality. The data came from 2 large-scale studies. One exposed 10 groups to different γ dose rates; the other exposed 8 groups to different lung burdens of plutonium...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28296320/a-comparative-study-based-on-image-quality-and-clinical-task-performance-for-ct-reconstruction-algorithms-in-radiotherapy
#12
Hua Li, Steven Dolly, Hsin-Chen Chen, Mark A Anastasio, Daniel A Low, Harold H Li, Jeff M Michalski, Wade L Thorstad, Hiram Gay, Sasa Mutic
CT image reconstruction is typically evaluated based on the ability to reduce the radiation dose to as-low-as-reasonably-achievable (ALARA) while maintaining acceptable image quality. However, the determination of common image quality metrics, such as noise, contrast, and contrast-to-noise ratio, is often insufficient for describing clinical radiotherapy task performance. In this study we designed and implemented a new comparative analysis method associating image quality, radiation dose, and patient size with radiotherapy task performance, with the purpose of guiding the clinical radiotherapy usage of CT reconstruction algorithms...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28244582/radiological-examinations-in-pediatric-age
#13
R Siciliano
Diagnostic radiology imaging is an essential tool for adequate clinical investigation of pathological processes and the drafting of a personalized therapy plan. However, in recent years, there has been a substantial increase of requests, mainly due to technological advances but also to social and cultural reasons, not always based on the principle of the diagnostic justification. The progress of recent years in the field of diagnostic radiology has made available to the physician a variety of sophisticated radiological examinations, which are not always used rationally and appropriately...
March 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28192209/a-new-alara-keeping-leadless-pacing-thresholds-as-low-as-reasonably-achievable
#14
EDITORIAL
Joseph E Marine
No abstract text is available yet for this article.
May 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28159651/a-multicenter-survey-of-endovascular-theatre-equipment-and-radiation-exposure-in-france-during-iliac-procedures
#15
Blandine Maurel, Adrien Hertault, Lucie Salomon du Mont, Sébastien Cazaban, Simon Rinckenbach
BACKGROUND: The aim of this study is to evaluate radiation exposure, endovascular theatre equipment, and practices in France during iliac angioplasty. METHODS: A prospective observational study was performed among vascular surgeons who attended a half day of radiation safety training in 2012 and 2015 and had to collect data on 3 patients undergoing iliac procedure. In 2012, 330 surgeons performed 899 procedures, compared with 114 surgeons and 338 procedures in 2015...
February 1, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28154358/systemization-of-the-establishment-of-standards-and-future-prospects-toward-the-establishment-of-standards-in-nonstationary-states
#16
REVIEW
Michio Murakami
Although public interest on safety standards is increasing, the evidence and protocols associated with the standards are not known well to the public and even experts. Discussing the evidence of standards is essential for risk communication, and interdisciplinary and systematical understanding on how to establish standards are also beneficial for considering the set-up of new standards. In this article, on the basis of examples in environmental science, industrial health and safety, and radiological protection, I overview and systemize the establishment of the standards from the perspectives of three principles of risk management: 1) "zero-risk-like" standards, 2) "acceptable-risk-based" standards, and 3) "cost-balanced" standards...
2017: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/28048491/su-f-sps-03-direct-measurement-of-organ-doses-resulting-from-head-and-cervical-spine-trauma-ct-protocols
#17
C Carranza, I Lipnharski, N Quails, N Correa, L Rill, M Arreola
PURPOSE: This retrospective study analyzes the exposure history of emergency department (ED) patients undergoing head and cervical spine trauma computed tomography (CT) studies. This study investigated dose levels received by trauma patients and addressed any potential concerns regarding radiation dose issues. METHODS: Under proper IRB approval, a cohort of 300 trauma cases of head and cervical spine trauma CT scans received in the ED was studied. The radiological image viewing software of the hospital was used to view patient images and image data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048267/su-f-i-30-minimization-of-resolution-loss-for-ct-scans-of-the-elbow-at-lateral-position
#18
Y Zhou, A Scott
PURPOSE: Resolution is vital in elbow CT in order to examine the details of fractures. However, it is significantly compromised when the elbow is at the lateral position due to the body attenuation and off-center position. We attempted to find the parameters to minimize the resolution loss while keeping the dose ALARA. METHODS: To simulate the medium and large patient respectively, an abdomen phantom (CIRS TE07) was used and then a fat-ring was added. A small tissue-equivalent phantom (CIRS TE02) simulating the elbow was connected to another smaller phantom (CIRS TE01)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048073/su-f-j-16-planar-kv-imaging-dose-reduction-study
#19
E Gershkevitsh, D Zolotuhhin
PURPOSE: IGRT has become an indispensable tool in modern radiotherapy with kV imaging used in many departments due to superior image quality and lower dose when compared to MV imaging. Many departments use manufacturer supplied protocols for imaging which are not always optimised between image quality and radiation dose (ALARA). METHODS: Whole body phantom PBU-50 (Kyoto Kagaku ltd., Japan) for imaging in radiology has been imaged on Varian iX accelerator (Varian Medical Systems, USA) with OBI 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046590/su-f-t-403-impact-of-dose-reduction-for-simulation-ct-on-radiation-therapy-treatment-planning
#20
Q Liang, P Shah, S Li, C Miyamoto
PURPOSE: To investigate the feasibility of applying ALARA principles to current treatment planning CT scans. The study aims to quantitatively verify lower dose scans does not alter treatment planning. METHOD: Gammex 467 tissue characterization phantom with inserts of 14 different materials was scanned at seven different mA levels (30∼300 mA). CT numbers of different inserts were measured. Auto contouring for bone and lung in treatment planning system (Pinnacle) was used to evaluate the effect of CT number accuracy from treatment planning aspect, on the 30 and 300 mA-scanned images...
June 2016: Medical Physics
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