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https://www.readbyqxmd.com/read/28821966/application-of-transcutaneous-ultrasonography-for-the-diagnosis-of-muscle-mass-loss-in-patients-with-liver-cirrhosis
#1
Kazufumi Kobayashi, Hitoshi Maruyama, Soichiro Kiyono, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Tetsuhiro Chiba, Naoya Kato, Tadashi Yamaguchi
BACKGROUND: To propose an ultrasound-based parameter for the diagnosis of muscle mass loss (MML) in cirrhosis. METHODS: This is an IRB-approved cross-sectional study (October 2013 to January 2017) with written informed consent including 357 subjects-234 cirrhosis and 123 controls. MML was diagnosed using the skeletal muscle index at the L3 level (L3-SMI) on computed tomography (CT). Transcutaneous ultrasound was used to demonstrate a cross section of the right iliopsoas muscle, and the iliopsoas muscle index (IP index) was defined by the iliopsoas muscle area/height(2) (mm(2)/m(2))...
August 18, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28817437/surgicopathological-quality-control-and-protocol-adherence-to-lymphadenectomy-in-the-critics-gastric-cancer-trial
#2
Yvette H M Claassen, Wobbe O de Steur, Henk H Hartgrink, Johan L Dikken, Johanna W van Sandick, Nicole C T van Grieken, Annemiek Cats, Anouk K Trip, Edwin P M Jansen, Willemina M Meershoek-Klein Kranenbarg, Jeffrey P B M Braak, Hein Putter, Mark I van Berge Henegouwen, Marcel Verheij, Cornelis J H van de Velde
OBJECTIVE: The purpose of this study was to evaluate surgicopathological quality and protocol adherence for lymphadenectomy in the CRITICS trial. SUMMARY OF BACKGROUND DATA: Surgical quality assurance is a key element in multimodal studies for gastric cancer. In the multicenter CRITICS trial (ChemoRadiotherapy after Induction chemotherapy In Cancer of the Stomach), patients with resectable gastric cancer were randomized for preoperative chemotherapy, followed by gastrectomy with a D1+ lymphadenectomy (removal of stations 1 to 9 and 11), followed by either chemotherapy or chemoradiotherapy...
August 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28755791/histology-based-assessment-of-sonazoid-enhanced-ultrasonography-for-the-diagnosis-of-liver-metastasis
#3
Kazufumi Kobayashi, Hitoshi Maruyama, Soichiro Kiyono, Osamu Yokosuka, Masayuki Ohtsuka, Masaru Miyazaki, Jun Matsushima, Takashi Kishimoto, Yukio Nakatani
This retrospective study aimed to assess the diagnostic performance of contrast-enhanced ultrasound with Sonazoid (S-CEUS) for liver metastasis. We enrolled in this study 98 patients with 148 histologically proven liver lesions, with 121 metastases and 27 non-metastases. The S-CEUS technique showed sensitivity in 95.0% (115 of 121), specificity in 44.4% (12 of 27) and accuracy in 85.8% (127 of 148) for the diagnosis of metastasis. Higher body mass index had a negative influence on the positive predictive value and accuracy, and a greater depth of the lesion had a negative influence on the accuracy...
October 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28755441/plan-quality-and-delivery-time-comparisons-between-volumetric-modulated-arc-therapy-and-intensity-modulated-radiation-therapy-for-scalp-angiosarcoma-a-planning-study
#4
Yudai Kai, Ryo Toya, Tetsuo Saito, Akiko Kuraoka, Yoshinobu Shimohigashi, Yuji Nakaguchi, Masato Maruyama, Ryuji Murakami, Yasuyuki Yamashita, Natsuo Oya
INTRODUCTION: Due to its spherical surface, scalp angiosarcoma requires careful consideration for radiation therapy planning and dose delivery. Herein, we investigated whether volumetric modulated arc therapy (VMAT) is superior to intensity modulated radiation therapy (IMRT) in terms of the plan quality and delivery time. METHODS: Three different coplanar treatment plans were created for four patients, comprising a two-arc VMAT plan as well as 5-field and 9-field IMRT plans with 6 MV beams...
July 29, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28736559/levocarnitine-injections-decrease-the-need-for-erythropoiesis-stimulating-agents-in-hemodialysis-patients-with-renal-anemia
#5
Takashi Maruyama, Terumi Higuchi, Toshio Yamazaki, Erina Okawa, Hideyuki Ando, Osamu Oikawa, Atsushi Inoshita, Kazuyoshi Okada, Masanori Abe
AIMS: The aim of this study was to evaluate the efficacy of levocarnitine injection for renal anemia in hemodialysis patients. METHODS: In this randomized controlled clinical trial, we randomly assigned patients on maintenance hemodialysis at our hospital to receive levocarnitine injections (n = 30) or no injection (n = 30) and monitored the patients during 12 months of treatment. In the treatment group, patients received an injection of levocarnitine 1,000 mg 3 times weekly after hemodialysis sessions...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28667795/dietary-intake-habits-and-prevalence-of-nocturia-in-japanese-patients-with-type-2-diabetes-mellitus
#6
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
AIMS/INTRODUCTION: No reports have been published on the association between dietary intake habits and nocturia in the diabetes population. We therefore estimate this issue among Japanese patients with diabetes mellitus. MATERIALS AND METHODS: Study subjects in the present study were 785 Japanese patients with type 2 diabetes mellitus. Self-administrated questionnaires were used to assess each type of dietary intake habits. Vegetable intake habit was assessed by the following question: Do you have vegetables or seaweed every day?" We used the following two outcomes: 1) nocturia: ≥ 2 voids per night and 2) severe nocturia: ≥ 3 voids per night...
July 1, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28660446/rationale-and-design-of-observational-clinical-research-in-chronic-kidney-disease-patients-with-renal-anemia-renal-prognosis-in-patients-with-hyporesponsive-anemia-to-erythropoiesis-stimulating-agents-darbepoetin-alfa-brighten-trial
#7
Hideki Kato, Masaomi Nangaku, Hideki Hirakata, Takashi Wada, Terumasa Hayashi, Hiroshi Sato, Yasushi Yamazaki, Takao Masaki, Tatsuo Kagimura, Hiroyasu Yamamoto, Hiroki Hase, Masahiro Kamouchi, Enyu Imai, Kyoichi Mizuno, Manabu Iwasaki, Tadao Akizawa, Yoshiharu Tsubakihara, Shoichi Maruyama, Ichiei Narita
BACKGROUND: Renal anemia is an important complication in non-dialysis chronic kidney disease (CKD) patients as well as in dialysis patients. Although recombinant human erythropoietin has dramatically improved prognosis and quality of life in these patients, there have been issues among non-dialysis CKD patients who exhibit hyporesponsiveness to erythropoiesis-stimulating agent (ESA). The causes and definition of ESA hyporesponsiveness, as well as the incidence of renal and cardiovascular disease (CVD) events in such patients, are yet to be clarified...
June 28, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28656733/obesity-and-the-prevalence-of-nocturia-in-japanese-elderly-patients-with-type%C3%A2-2-diabetes-mellitus-the-dogo-study
#8
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
AIM: Nocturia is common among patients with type 2 diabetes mellitus, but limited evidence regarding the association between body mass index (BMI) and nocturia exists among such patients. The aim of the present study, therefore, was to evaluate the association between BMI and nocturia among Japanese patients with type 2 diabetes mellitus. METHODS: Study participants were 809 Japanese patients with type 2 diabetes mellitus. Study participants were considered to have nocturia if they answered "two or more" to the question: "How many times do you typically wake up to urinate from sleeping at night until waking in the morning?" We used the following two outcomes: (i) moderate nocturia was defined as ≥2 voids per night; and (ii) severe nocturia was defined as ≥3 voids per night...
June 28, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28621046/impact-of-borderline-subclinical-hypothyroidism-on-subsequent-pregnancy-outcome-in-women-with-unexplained-recurrent-pregnancy-loss
#9
Sayaka Uchida, Tetsuo Maruyama, Maki Kagami, Fumie Miki, Hanako Hihara, Satomi Katakura, Yushi Yoshimasa, Hirotaka Masuda, Hiroshi Uchida, Mamoru Tanaka
AIM: Because subclinical hypothyroidism (thyroid-stimulating hormone [TSH] > 4.5 IU/mL) is associated with adverse pregnancy outcome, including early pregnancy loss, TSH is recommended to be titrated to ≤2.5 mIU/L in levothyroxine-treated women before pregnancy. The purpose of this study was to determine whether borderline-subclinical hypothyroidism (borderline-SCH; 2.5 < TSH ≤ 4.5 IU/mL) affects the outcome of subsequent pregnancies in women with unexplained recurrent pregnancy loss (uRPL)...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28575005/various-meteorological-conditions-exhibit-both-immediate-and-delayed-influences-on-the-risk-of-stroke-events-the-hews-stroke-study
#10
Tomoya Mukai, Naohisa Hosomi, Miwako Tsunematsu, Yoshimasa Sueda, Yutaka Shimoe, Tomohiko Ohshita, Tsuyoshi Torii, Shiro Aoki, Tomohisa Nezu, Hirofumi Maruyama, Masayuki Kakehashi, Masayasu Matsumoto
We hypothesized that meteorological conditions on the onset day and conditions on the former days may play important roles in the modulation of physical conditions. Associations of meteorological factors and their changes in former days with stroke onset are of interest. We conducted a multicenter retrospective study to evaluate the frequency of stroke events and their interaction with meteorological conditions and their daily changes. Acute stroke patients (n = 3935, 73.5±12.4 years, 1610 females) who were admitted to 7 stroke hospitals in three restricted areas were enrolled in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28566656/low-heart-rate-variability-and-sympathetic-dominance-modifies-the-association-between-insulin-resistance-and-metabolic-syndrome%C3%A3-the-toon-health-study
#11
Isao Saito, Koutatsu Maruyama, Eri Eguchi, Tadahiro Kato, Ryoichi Kawamura, Yasunori Takata, Hiroshi Onuma, Haruhiko Osawa, Takeshi Tanigawa
BACKGROUND: Insulin resistance is strongly associated with metabolic syndrome (MetS), but it is not known how this association is influenced by the autonomic nervous system, which controls insulin secretion.Methods and Results:The subjects were 2,016 individuals aged 30-79 years enrolled between 2009 and 2012. MetS was determined using the harmonized MetS definition, which includes waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting glucose...
May 30, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28565790/level-of-serum-undercarboxylated-osteocalcin-correlates-with-bone-quality-assessed-by-calcaneal-quantitative-ultrasound-sonometry-in-young-japanese-females
#12
Yoshio Suzuki, Asako Maruyama-Nagao, Keishoku Sakuraba, Sachio Kawai
The diagnostic criteria of osteoporosis were established based on bone mineral density (BMD). Therefore, BMD measured by dual energy X-ray absorptiometry has been recognized as the gold standard to diagnose osteoporosis. However, discrepancies between fracture risk and BMD have been recognized. Bone is composed of collagen scaffold reinforced by hydroxyapatite. Both protein scaffold and hydroxyapatite are involved in bone quality. BMD may indicate bone mineralization but potentially fail to assess the protein scaffold...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28548303/scalloped-tongue-is-associated-with-nocturnal-intermittent-hypoxia-among-community-dwelling-japanese-the-toon-health-study
#13
K Tomooka, T Tanigawa, S Sakurai, K Maruyama, E Eguchi, S Nishioka, N Miyoshi, H Kakuto, G Shimizu, D Yamaoka, I Saito
Scalloped tongue is considered as a possible clinical finding of obstructive sleep apnoea (OSA). There are few evidence of the association between scalloped tongue and OSA. To examine the association between scalloped tongue and nocturnal intermittent hypoxia (NIH), a surrogate marker of OSA, among a general Japanese population. Study participants were 398 men and 732 women aged 30-79 years who participated in the Toon Health Study from 2011 to 2014. Scalloped tongue was classified into three categories: none, mild and moderate-to-severe...
May 26, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28516131/the-cardiac-sympathetic-nerve-activity-in-the-elderly-is-attenuated-in-the-right-lateral-decubitus-position
#14
Konosuke Sasaki, Mayu Haga, Sarina Bao, Haruka Sato, Yoshikatsu Saiki, Ryoko Maruyama
Objectives: The aim of this study was to evaluate the effect of the supine, left lateral decubitus, and right lateral decubitus positions on autonomic nervous activity in elderly adults by using spectral analysis of heart rate variability (HRV). Method: Forty-five adults aged 73.6 ± 5.7 years were enrolled. After lying in the supine position, all participants moved to the lateral decubitus positions in a random order and maintained the positions for 10 min, while electrocardiographic data were recorded to measure HRV...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/28515927/body-mass-index-as-a-classifier-to-predict-biochemical-recurrence-after-radical-prostatectomy-in-patients-with-lower-prostate-specific-antigen-levels
#15
Keisuke Goto, Hirotaka Nagamatsu, Jun Teishima, Yuki Kohada, Shinsuke Fujii, Yoshimasa Kurimura, Koji Mita, Masanobu Shigeta, Satoshi Maruyama, Yoji Inoue, Mitsuru Nakahara, Akio Matsubara
Prostate cancer, one of the most common malignant tumors among men, is closely associated with obesity and, thus far, several studies have suggested the association between obesity and aggressive pathological characteristics in the United States. However, the effect of obesity on prostate cancer mortality is controversial, and it remains unclear whether obesity contributes to the aggressiveness of prostate cancer in Asian patients. The aim of the present study was to investigate the association between body mass index (BMI) and the clinicopathological characteristics of prostate cancer in 2,003 Japanese patients who underwent radical prostatectomy...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28515921/association-between-periodontitis-and-prognosis-of-pancreatobiliary-tract-cancer-a-pilot-study
#16
Takayuki Maruyama, Takaaki Tomofuji, Tatsuya Machida, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Toshiki Yoneda, Hisataka Miyai, Hirofumi Mizuno, Daisuke Ekuni, Hiroyuki Okada, Manabu Morita
Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28507513/appetitive-olfactory-learning-and-long-term-associative-memory-in-caenorhabditis-elegans
#17
Saori Nishijima, Ichiro N Maruyama
Because of the relative simplicity of its nervous system, Caenorhabditis elegans is a useful model organism to study learning and memory at cellular and molecular levels. For appetitive conditioning in C. elegans, food has exclusively been used as an unconditioned stimulus (US). It may be difficult to analyze neuronal circuits for associative memory since food is a multimodal combination of olfactory, gustatory, and mechanical stimuli. Here, we report classical appetitive conditioning and associative memory in C...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28502918/ability-of-the-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-to-predict-the-3-month-outcome-in-patients-with-non-cardioembolic-stroke
#18
Hayato Matsushima, Naohisa Hosomi, Naoyuki Hara, Takeshi Yoshimoto, Shuichiro Neshige, Ryuhei Kono, Takahiro Himeno, Shinichi Takeshima, Kazuhiro Takamatsu, Yutaka Shimoe, Taisei Ota, Hirofumi Maruyama, Toshiho Ohtsuki, Masaru Kuriyama, Masayasu Matsumoto
AIM: Both the ankle brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are surrogates for atherosclerosis. In this study, we aimed to evaluate the ability of ABI and baPWV to predict stroke outcome in patients with first-ever non-cardioembolic stroke. METHODS: This study included consecutive patients with first-ever non-cardioembolic stroke admitted within 1 week after onset to Ota Memorial Hospital between January 2011 and December 2013. Baseline characteristics and National Institutes of Health stroke scale scores at admission were noted...
May 15, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28420835/macrovascular-complications-and-prevalence-of-urgency-incontinence-in-japanese-patients-with-type-2-diabetes-mellitus-the-dogo-study
#19
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Sayaka Kanzaki, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Morikazu Onji, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
Objective Macrovascular diseases and urgency incontinence are common among Japanese patients with type 2 diabetes mellitus. However, little evidence exists regarding the association between stroke and urgency incontinence among patients with type 2 diabetes mellitus. We examined the associations between macrovascular complications and urgency incontinence among Japanese patients with type 2 diabetes mellitus. Methods The study subjects were 818 Japanese patients with type 2 diabetes mellitus. Urgency incontinence was defined as present when a subject answered "once a week or more" to the question: "Within one week, how often do you leak urine because you cannot defer the sudden desire to urinate?" We adjusted our analyses for sex, age, body mass index, duration of type 2 diabetes, current smoking, current drinking, hypertension, dyslipidemia, glycated hemoglobin, diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28367084/interrelationship-between-insulin-resistance-and-portal-haemodynamic-abnormality-in-cirrhosis
#20
Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Osamu Yokosuka
Background: There are only limited data regarding the effect of impaired portal circulation on the glucose metabolism. The study prospectively examined the interrelationship between insulin resistance (IR) and portal haemodynamic abnormality in cirrhosis. Methods: There were 53 cirrhosis patients (61.6 ± 13.0 years) all presenting gastroesophageal varices. Portal haemodynamics by both hepatic venous catheterisation and Doppler ultrasound were examined with respect to the homeostasis model assessment (HOMA)-IR and HOMA2-IR...
2017: International Journal of Medical Sciences
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