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https://www.readbyqxmd.com/read/29652082/association-between-hospital-volume-and-quality-of-gastric-cancer-surgery-in-the-critics-trial
#1
Y H M Claassen, J W van Sandick, H H Hartgrink, J L Dikken, W O De Steur, N C T van Grieken, H Boot, A Cats, A K Trip, E P M Jansen, W M Meershoek-Klein Kranenbarg, J P B M Braak, H Putter, M I van Berge Henegouwen, M Verheij, C J H van de Velde
BACKGROUND: Studies investigating the association between hospital volume and quality of gastric cancer surgery are lacking. In the present study, the effect of hospital volume on quality of gastric cancer surgery was evaluated by analysing data from the CRITICS (ChemoRadiotherapy after Induction chemotherapy In Cancer of the Stomach) trial. METHODS: Patients who underwent gastrectomy with curative intent in the Netherlands were selected from the CRITICS trial database...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29618055/malignancy-index-using-intraoperative-flow-cytometry-is-a-valuable-prognostic-factor-for-glioblastoma-treated-with-radiotherapy-and-concomitant-temozolomide
#2
Taiichi Saito, Yoshihiro Muragaki, Takahiro Shioyama, Takashi Komori, Takashi Maruyama, Masayuki Nitta, Takayuki Yasuda, Junji Hosono, Saori Okamoto, Takakazu Kawamata
BACKGROUND: Intraoperative prediction of radiochemosensitivity is desirable for improving the clinical management of glioblastoma (GBM) patients. We have previously developed an original technique for intraoperative flow cytometry (iFC) and defined a malignancy index (MI). OBJECTIVE: To determine whether MI correlates with prognosis in GBM patients who underwent the standard treatment protocol of radiotherapy and temozolomide administration. METHODS: The current study included 102 patients with GBM that had been newly diagnosed from 2010 to 2015 who underwent our iFC analysis and received the standard treatment protocol...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29572766/cd3-cd56-eber1-atypical-extraosseous-plasmacytoma-of-the-nasal-cavity
#3
Yayoi Ando, Akiko Miyagi Maeshima, Suguru Fukuhara, Shinichi Makita, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Hirokazu Taniguchi, Koji Izutsu
We present a case of atypical extraosseous plasmacytoma (EP) with a plasmablastic morphology and CD3+ CD56+ Epstein-Barr virus-encoded RNA-1 (EBER1)+ phenotypes of the nasal cavity. A 51-year-old male attended a local hospital with a tumor located in his left nasal cavity that was histologically diagnosed as extranodal NK/T cell lymphoma, nasal type. We reviewed the specimens and re-biopsied the tumor, and confirmed that the tumor was positive for CD3, CD56, and EBER1; however, the tumor showed a plasmablastic morphology without necrosis and angiocentricity, and was positive for CD138, but negative for CD20 and PAX5...
March 23, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29569850/modeling-of-the-weight-status-and-risk-of-non-alcoholic-fatty-liver-disease-in-elderly-individuals-the-potential-impact-of-the-dsba-l-polymorphism-on-the-weight-status
#4
Kentaro Oniki, Takehisa Watanabe, Miku Kudo, Tomoko Izuka, Tatsumasa Ono, Kazuki Matsuda, Yuki Sakamoto, Katsuya Nagaoka, Tadashi Imafuku, Yu Ishima, Hiroshi Watanabe, Toru Maruyama, Koji Otake, Yasuhiro Ogata, Junji Saruwatari
Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity. Disulfide bond-forming oxidoreductase A-Like protein (DsbA-L) is known to be a key molecule in protection against obesity and obesity-induced inflammation. In the present study, we used a modeling and simulation approach in an attempt to develop body mass index (BMI) and BMI-based NAFLD prediction models incorporating the DsbA-L polymorphism to predict the BMI and NAFLD in 341 elderly subjects. A nonlinear mixed-effect model best represented the sigmoidal relationship between the BMI and the logit function of the probability of NAFLD prevalence...
March 23, 2018: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29534839/promoter-hypomethylation-of-ski-in-autoimmune-pancreatitis
#5
Yasuhiro Kinugawa, Takeshi Uehara, Kazuyuki Matsuda, Yukihiro Kobayashi, Tomoyuki Nakajima, Hideaki Hamano, Shigeyuki Kawa, Kayoko Higuchi, Noriko Hosaka, Satoshi Shiozawa, Hiroki Ishigame, Toshitsugu Nakamura, Yasuhiro Maruyama, Koh Nakazawa, Masato Nakaguro, Kenji Sano, Hiroyoshi Ota
The relationship between methylation abnormality and autoimmune pancreatitis (AIP)-a representative IgG4-related disease-has not yet been elucidated. We identified SKI might have a significant methylation abnormality in AIP through methylation array analysis using the Illumina Infinium Human Methylation 450K BeadChip array, and investigated the relationship of SKI with AIP clinicopathological features. The methylation rate of SKI was assessed by quantitative SYBR green methylation-specific PCR, and the degree of SKI expression in tissue specimens was assessed by immunohistochemistry in 10 AIP cases, 14 cases of obstructive pancreatitis area in pancreatic ductal adenocarcinoma (PDA) without a history of AIP, and 9 normal pancreas (NP) cases...
March 6, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29522936/evaluation-of-dna-ploidy-with-intraoperative-flow-cytometry-may-predict-long-term-survival-of-patients-with-supratentorial-low-grade-gliomas-analysis-of-102-cases
#6
Akane Suzuki, Takashi Maruyama, Masayuki Nitta, Takashi Komori, Soko Ikuta, Mikhail Chernov, Manabu Tamura, Takakazu Kawamata, Yoshihiro Muragaki
OBJECTIVE: The objective of the present study was evaluation of the prognostic significance of DNA ploidy assessed with intraoperative flow cytometry (iFC) during resection of low-grade gliomas (LGG). PATIENTS AND METHODS: Retrospective analysis of 102 consecutive cases of newly diagnosed WHO grade II supratentorial gliomas, surgical removal of which was accompanied by iFC, was done. There were 46 diffuse astrocytomas (DA) and 56 oligodendrogliomas (OD). According to iFC, 68 tumors (67%) were considered non-aneuploid and 34 (33%) aneuploid...
February 21, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29511130/desirable-low-density-lipoprotein-cholesterol-levels-for-preventing-stroke-recurrence-a-post-hoc-analysis-of-the-j-stars-study-japan-statin-treatment-against-recurrent-stroke
#7
Naohisa Hosomi, Kazuo Kitagawa, Yoji Nagai, Yoko Nakagawa, Shiro Aoki, Tomohisa Nezu, Tatsuo Kagimura, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masayasu Matsumoto
BACKGROUND AND PURPOSE: To define desirable target low-density lipoprotein (LDL) cholesterol levels for the prevention of stroke recurrence, a post hoc analysis was performed in the J-STARS study (Japan Statin Treatment Against Recurrent Stroke). METHODS: Subjects (n=1578) were divided into groups based on mean value of postrandomized LDL cholesterol levels until the last observation in 20 mg/dL increments. Adjusted hazard ratios (HRs) and 95% confidence intervals were analyzed for each group, with adjustments for baseline LDL cholesterol, baseline body mass index, hypertension, diabetes mellitus, and statin usage...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29503373/-dietary-approach-to-improving-the-nutritional-status-in-institutionalized-elderly-hemodialysis-patients-with-a-poor-dietary-intake-a-single-arm-pilot-study
#8
Makiko Yamashita, Rieko Komatsu, Yuko Maruyama, Tomoyuki Takaki, Hiroshi Ichinose, Osamu Sasaki, Kenji Sawase, Takashi Harada, Satoshi Funakoshi
OBJECTIVE: The hemodialysis (HD) diet, which is a high-calorie and high-fat regimen, may inadvertently lead to an inadequate dietary intake, resulting in undernutrition among elderly HD patients. Therefore, an attempt was made to improve the dietary intake by implementing a modified diet regimen in eligible elderly HD patients. SUBJECTS: Elderly HD patients who had ingested < 50% of the meals provided and were diagnosed with undernutrition among all elderly patients institutionalized at the special elderly nursing home annexed to Nagasaki Kidney Hospital between June and November 2012...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29472086/image-quality-of-four-dimensional-cone-beam-computed-tomography-obtained-at-various-gantry-rotation-speeds-for-liver-stereotactic-body-radiation-therapy-with-fiducial-markers
#9
Yoshinobu Shimohigashi, Fujio Araki, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Ryo Toya
In this study, qualities of 4D cone-beam CT (CBCT) images obtained using various gantry rotation speeds (GRSs) for liver stereotactic body radiation therapy (SBRT) with fiducial markers were quantitatively evaluated. Abdominal phantom containing a fiducial marker was moved along a sinusoidal waveform, and 4D-CBCT images were acquired with GRSs of 50-200° min-1 . We obtained the 4D-CBCT projection data from six patients who underwent liver SBRT and generated 4D-CBCT images at GRSs of 67-200° min-1 , by varying the number of projection data points...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29462515/risk-factor-for-diabetes-mellitus-and-high-blood-glucose-with-hmg-coa-reductase-inhibitors-using-a-postmarketing-surveillance-database-in-japan
#10
Masayuki Hashiguchi, Junya Maruyama, Mikiko Shimizu, Daichi Takahashi, Tsuyoshi Shiga
To investigate whether 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statin) use is associated with an increased risk of diabetes mellitus and hyperglycemia, we performed a nested case-control study using a postmarketing surveillance database in Japan. The database cohort included 26,849 cases of statin use and 5308 cases of other lipid-lowering drug use in patients with hyperlipidemia. Participants received at least 1 type of statin, had a clear medication history of statin use, and had no complications of diabetes mellitus...
February 20, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29446092/association-of-salivary-lactate-dehydrogenase-level-with-systemic-inflammation-in-a-japanese-population
#11
N Miyoshi, T Tanigawa, S Nishioka, K Maruyama, E Eguchi, K Tanaka, I Saito, K Yamazaki, Y Miyake
BACKGROUND AND OBJECTIVE: Salivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross-sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C-reactive protein (hs-CRP) levels in a community-based middle-aged and elderly population in Japan...
February 15, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29442800/characterization-of-articaine-loaded-poly-%C3%AE%C2%B5-caprolactone-nanocapsules-and-solid-lipid-nanoparticles-in-hydrogels-for-topical-formulations
#12
Nathalie Ferreira Silva de Melo, Estefânia Vangelie Ramos Campos, Michelle Franz-Montan, Eneida de Paula, Camila Morais Gonçalves da Silva, Cíntia Rodrigues Maruyama, Tatiane Pasquoto Stigliani, Renata de Lima, Daniele Ribeiro de Araújo, Leonardo Fernandes Fraceto
This work describes the development of poly-ε-caprolactone nanocapsules (PCL-NC) and solid lipid nanoparticles (SLN) aiming delivery for articaine (ATC), in order to improve its chemical stability in semi-solid preparations looking forward their use for skin delivery. The nanoparticles were characterized by size, polydispersity index, and pH. Cellular viability was evaluated using the MTT test and the in vitro release kinetics was determined using a two-compartment model. The hydrogels with nanoparticle suspensions were characterized considering their rheological aspects and in vitro permeation across artificial membranes...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29435809/body-mass-index-predicts-insulin-sensitivity-during-cardiac-surgery-a-prospective-observational-study
#13
Yosuke Nakadate, Hiroaki Sato, Tamaki Sato, Takumi Codere-Maruyama, Takashi Matsukawa, Thomas Schricker
PURPOSE: Taking into account the previously described link between body weight and diabetes mellitus (DM) in non-surgical patients, and the understanding that the degree of intraoperative insulin resistance is a predictor of adverse clinical outcomes, we investigated the relationship between body mass index (BMI) and insulin sensitivity during cardiac surgery. METHODS: We prospectively enrolled 400 patients scheduled for elective cardiac surgery and divided them into groups based on the presence or absence of type-2 DM...
February 12, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29399105/health-related-quality-of-life-on-the-clinical-course-of-patients-with-chronic-hepatitis-c-receiving-daclatasvir-asunaprevir-therapy-a-prospective-observational-study-comparing-younger-70-and-elderly-%C3%A2-70-patients
#14
Kazuki Ohashi, Toru Ishikawa, Mitsuyuki Suzuki, Hiroko Abe, Fujiko Koyama, Tomomi Nakano, Aya Ueki, Hirohito Noguchi, Erina Hasegawa, Shiori Hirosawa, Miki Kobayashi, Hiroshi Hirosawa, Kaede Sato, Takako Fukazawa, Yuka Maruyama, Toshiaki Yoshida
Interferon-free direct acting antiviral agent regimens for chronic hepatitis C (CHC) have been developed. These regimens have shown a high rate of sustained virologic response (SVR), and a reduction in side effects during treatment is also anticipated. However, the impact of the regimens on health-related quality of life (HRQOL) and side effects during treatment is not fully understood. The purpose of the present study was to evaluate HRQOL in the clinical course of patients with CHC receiving daclatasvir/asunaprevir (DCV/ASV) therapy using the Short Form-36 (SF-36) method...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398940/improving-preharvest-sprouting-resistance-in-durum-wheat-with-bread-wheat-genes
#15
Keita Kato, Wakako Maruyama-Funatsuki, Mikiko Yanaka, Yusuke Ban, Kanenori Takata
Preharvest sprouting (PHS) of durum wheat ( Triticum turgidum ssp. durum (Desf.) Husn.) is an important problem in Japan, where the rainy season overlaps with the harvest season. Since there are few PHS-resistant genetic resources in durum wheat, we introduced an R -gene for red seeds, the MFT gene, and the QPhs-5AL QTL, all of which are associated with PHS resistance, into durum wheat from a PHS-resistant bread wheat ( T. aestivum L.) cultivar, 'Zenkoujikomugi' (Zen), by backcross breeding. Developed near isogenic lines (NILs) with red seeds had a lower percentage germination (PG) and germination index (GI) than the recurrent parent, and seed color had the greatest effect...
December 2017: Breeding Science
https://www.readbyqxmd.com/read/29316022/association-between-buccal-mucosa-ridging-and-oral-or-occlusal-status-among-older-people
#16
Koji Morita, Takahiro Mori, Mariko Maruyama, Aya Hiraoka, Chiaki Higa, Azusa Kuroki, Mitsuyoshi Yoshida, Kazuhiro Tsuga
OBJECTIVES: This study aimed to evaluate the association between buccal mucosa ridging and oral or occlusal statuses among older people. SUBJECTS AND METHODS: This cross-sectional study examined 262 independent older people (mean age, 74.2 ± 5.9 years) who participated in the Kyoto Elderly Physical Fitness Measurement Research Project. The predictor variables were oral statuses (number of present teeth and torus palatinus, torus mandibularis, temporomandibular joint noise, clenching, or grinding) and oral functions (occlusal pressure, cheek pressure, oral diadochokinesis, and tongue pressure)...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29311441/yellow-tongue-coating-is-associated-with-diabetes-mellitus-among-japanese-non-smoking-men-and-women-the-toon-health-study
#17
Kiyohide Tomooka, Isao Saito, Shinya Furukawa, Koutatsu Maruyama, Eri Eguchi, Hiroyasu Iso, Takeshi Tanigawa
BACKGROUND: Yellow tongue coating is one of the clinical signs for diabetes mellitus according to traditional East Asian medicine. Few reports have been available on the association between yellow tongue coating and the prevalence of type 2 diabetes in the general population. We examined that association among population samples of non-smoking men and women. METHODS: The study subjects were Japanese non-smoking men (n = 315) and women (n = 654) aged 30-79 years who resided in Toon city and participated in the Toon Health Study from July 2011 through November 2014...
December 28, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29291198/effect-of-helicobacter-pylori-eradication-on-elder-cases-observational-study-in-community-based-medicine
#18
Masaki Maruyama, Kenya Kamimura, Ayako Hoshiyama, Koki Hoshiyama, Mari Hoshiyama, Yoshihiro Hoshiyama, Shuji Terai
AIM: To examine the effect of Helicobacter pylori ( H. pylori ) eradication therapy on the extra-gastrointestinal factors in elderly patients by a before-after observational study in community medicine. METHODS: Medical records (1 May 2013-31 January 2014) of 130 patients who underwent H. pylori eradication therapy with 2-year after-eradication observation in our institute were reviewed. Data on sex; age; body weight; body mass index (BMI); mean corpuscular volume (MCV); total protein; low-density lipoprotein cholesterol, triglyceride, haemoglobin A1c and haemoglobin levels and gastric hyperplastic polyps (GHPs) at eradication was extracted...
December 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29290485/tricuspid-valve-adaptation-during-the-first-interstage-period-in-hypoplastic-left-heart-syndrome
#19
Timothy Colen, Shelby Kutty, Richard B Thompson, Edythe Tham, Andrew S Mackie, Ling Li, Dongngan T Truong, Michiko Maruyama, Jeffrey F Smallhorn, Nee Scze Khoo
BACKGROUND: Tricuspid regurgitation (TR) is an important risk factor for morbidity and mortality in hypoplastic left heart syndrome (HLHS), yet the evolution of tricuspid valve (TV) dysfunction in HLHS is poorly understood. This study sought to examine changes in TV function in HLHS between the first two stages of surgical palliation and to determine the mechanism of TR at the time of stage two surgery-bidirectional cavopulmonary anastomosis (BCPA). METHODS: We prospectively investigated 44 infants at two time points-prior to Norwood-Sano (T1 - median age 5...
December 29, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29190646/risk-factors-for-incidental-durotomy-during-posterior-open-spine-surgery-for-degenerative-diseases-in-adults-a-multicenter-observational-study
#20
MULTICENTER STUDY
Hisatoshi Ishikura, Satoshi Ogihara, Hiroyuki Oka, Toru Maruyama, Hirohiko Inanami, Kota Miyoshi, Ko Matsudaira, Hirotaka Chikuda, Seiichi Azuma, Naohiro Kawamura, Kiyofumi Yamakawa, Nobuhiro Hara, Yasushi Oshima, Jiro Morii, Kazuo Saita, Sakae Tanaka, Takashi Yamazaki
Incidental durotomy (ID) is a common intraoperative complication of spine surgery. It can lead to persistent cerebrospinal fluid leakage, which may cause serious complications, including severe headache, pseudomeningocele formation, nerve root entrapment, and intracranial hemorrhage. As a result, it contributes to higher healthcare costs and poor patient outcomes. The purpose of this study was to clarify the independent risk factors that can cause ID during posterior open spine surgery for degenerative diseases in adults...
2017: PloS One
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