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https://www.readbyqxmd.com/read/29901705/phase-iii-study-of-watchful-waiting-vs-rituximab-as-first-line-treatment-in-advanced-stage-follicular-lymphoma-with-low-tumour-burden-jcog1411-flora-study
#1
Kenichi Miyamoto, Noriko Fukuhara, Dai Maruyama, Taro Shibata, Kenichi Nakamura, Kenichi Ishizawa, Kunihiro Tsukasaki, Hirokazu Nagai
A randomized phase III trial comparing watchful waiting with first-line rituximab for advanced stage follicular lymphoma commenced in Japan in December 2016. Watchful waiting is the current standard treatment for stages III and IV (Ann Arbor classification) follicular lymphoma with low tumour burden. This study aimed to confirm the superiority of early administration of first-line rituximab in terms of event-free survival to watchful waiting for stages III and IV follicular lymphoma with low tumour burden. A total of 290 patients will be accrued from 50 Japanese institutions within 5 years...
June 13, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29893003/comparative-study-of-ipragliflozin-with-sitagliptin-on-multiple-metabolic-changes-in-japanese-patients-with-type-2-diabetes-a-multicenter-randomized-prospective-open-label-active-controlled-study
#2
Yuya Tsurutani, Kazuki Nakai, Kosuke Inoue, Azuma Kosuke, Sei Mukai, Seitaro Maruyama, Takashi Iizuka, Yoko Matsuzawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
This randomized study assessed the efficacy of ipragliflozin compared with sitagliptin in 124 Japanese patients with type 2 diabetes. Sodium-glucose cotransporter 2 inhibitor and incretin-related agent naïve patients were randomly assigned to receive additional 50 mg ipragliflozin or sitagliptin. The primary endpoint was the proportion of patients with more than 0.5% decrease in HbA1c without body weight gain at 12 weeks. For secondary endpoints, we measured several biomarkers related to metabolic changes...
June 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29874654/ferric-citrate-decreases-fibroblast-growth-factor-23-and-improves-erythropoietin-responsiveness-in-hemodialysis-patients
#3
Noriaki Maruyama, Tomoyasu Otsuki, Yoshinori Yoshida, Chinami Nagura, Maki Kitai, Nami Shibahara, Hyoe Tomita, Takashi Maruyama, Masanori Abe
BACKGROUND: Serum phosphate and vitamin D receptor activator regulate fibroblast growth factor 23 (FGF23), and iron may modulate FGF23 metabolism. The aim of the present study was to elucidate the effects of ferric citrate hydrate and lanthanum carbohydrate on serum FGF23 levels in hemodialysis patients. METHODS: This prospective, open-label, multicenter study enrolled 60 patients on hemodialysis treated with lanthanum carbonate. Patients were randomly assigned to 2 groups: those switching from lanthanum carbonate to ferric citrate hydrate (ferric citrate group, n = 30) or those continuing lanthanum carbonate (control group, n = 30)...
June 6, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29716035/study-of-fabrication-reproducibility-of-two-mode-optical-fibers-for-mode-division-multiplexing-with-mimo-processing
#4
Ryo Maruyama, Masaharu Ohashi, Kimitaka Watanabe, Nori Shibata, Nobuo Kuwaki, Shoichiro Matsuo
We propose a two-mode optical fiber (TMF) with a low sensitivity of differential modal group delay (DMD) to change of the core radius and the refractive index of the core in the index profile which are major factors for DMD deviation. This was done to achieve high reproducibility of fiber fabrication. The proposed TMF has a graded index (GI) core and a depressed inner cladding, and we optimize structural parameters. We fabricated different kinds of TMFs to confirm the low DMD sensitivity of our proposed fiber...
April 30, 2018: Optics Express
https://www.readbyqxmd.com/read/29701171/risk-factors-for-rhabdomyolysis-with-hmg-coa-reductase-inhibitors-identified-using-a-postmarketing-surveillance-database-in-japan
#5
Masayuki Hashiguchi, Jun Hakamata, Mikiko Shimizu, Junya Maruyama, Tsuyoshi Shiga, Mayumi Mochizuki
OBJECTIVE: To investigate quantitatively the risk factors for rhabdomyolysis or related symptoms associated with HMG-CoA reductase inhibitors (statins), we used the lipid-lowering drug database (32,157 patients) developed by the RAD-AR Council, Japan, based on the postmarketing surveillance (PMS) data of pharmaceutical companies to perform a nested case-control study. MATERIALS AND METHODS: Of 26,849 patients taking statins, the case group was composed of 51 patients who experienced rhabdomyolysis or related symptoms while taking statins, and the control group was 1,020 patients randomly selected from patients who did not experience rhabdomyolysis or related symptoms while taking statins...
April 27, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29700638/prognostic-impact-of-bleomycin-pulmonary-toxicity-on-the-outcomes-of-patients-with-germ-cell-tumors
#6
Yuki Maruyama, Takuya Sadahira, Yosuke Mitsui, Motoo Araki, Koichiro Wada, Ryuta Tanimoto, Yasuyuki Kobayashi, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu
Bleomycin pulmonary toxicity (BPT) has been well described in patients with germ cell tumors treated with bleomycin etoposide and cisplatin chemotherapy (BEP). To assess the prognostic impact of BPT, we retrospectively identified 52 patients who underwent bleomycin etoposide and cisplatin chemotherapy from 2008 to 2017 in our institution, and evaluated the risk factors of BPT and its effect on prognosis. Patients who had received chemotherapy at another institution were excluded. BPT was defined as bleomycin discontinuation in response to pulmonary function test decline, pulmonary symptoms, or interstitial pneumonia on computed tomography without infection...
April 26, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29652082/association-between-hospital-volume-and-quality-of-gastric-cancer-surgery-in-the-critics-trial
#7
Y H M Claassen, J W van Sandick, H H Hartgrink, J L Dikken, W O De Steur, N C T van Grieken, H Boot, A Cats, A K Trip, E P M Jansen, W M Meershoek-Klein Kranenbarg, J P B M Braak, H Putter, M I van Berge Henegouwen, M Verheij, C J H van de Velde
BACKGROUND: Studies investigating the association between hospital volume and quality of gastric cancer surgery are lacking. In the present study, the effect of hospital volume on quality of gastric cancer surgery was evaluated by analysing data from the CRITICS (ChemoRadiotherapy after Induction chemotherapy In Cancer of the Stomach) trial. METHODS: Patients who underwent gastrectomy with curative intent in the Netherlands were selected from the CRITICS trial database...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29618055/malignancy-index-using-intraoperative-flow-cytometry-is-a-valuable-prognostic-factor-for-glioblastoma-treated-with-radiotherapy-and-concomitant-temozolomide
#8
Taiichi Saito, Yoshihiro Muragaki, Takahiro Shioyama, Takashi Komori, Takashi Maruyama, Masayuki Nitta, Takayuki Yasuda, Junji Hosono, Saori Okamoto, Takakazu Kawamata
BACKGROUND: Intraoperative prediction of radiochemosensitivity is desirable for improving the clinical management of glioblastoma (GBM) patients. We have previously developed an original technique for intraoperative flow cytometry (iFC) and defined a malignancy index (MI). OBJECTIVE: To determine whether MI correlates with prognosis in GBM patients who underwent the standard treatment protocol of radiotherapy and temozolomide administration. METHODS: The current study included 102 patients with GBM that had been newly diagnosed from 2010 to 2015 who underwent our iFC analysis and received the standard treatment protocol...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29572766/cd3-cd56-eber1-atypical-extraosseous-plasmacytoma-of-the-nasal-cavity
#9
Yayoi Ando, Akiko Miyagi Maeshima, Suguru Fukuhara, Shinichi Makita, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Hirokazu Taniguchi, Koji Izutsu
We present a case of atypical extraosseous plasmacytoma (EP) with a plasmablastic morphology and CD3+ CD56+ Epstein-Barr virus-encoded RNA-1 (EBER1)+ phenotypes of the nasal cavity. A 51-year-old male attended a local hospital with a tumor located in his left nasal cavity that was histologically diagnosed as extranodal NK/T cell lymphoma, nasal type. We reviewed the specimens and re-biopsied the tumor, and confirmed that the tumor was positive for CD3, CD56, and EBER1; however, the tumor showed a plasmablastic morphology without necrosis and angiocentricity, and was positive for CD138, but negative for CD20 and PAX5...
March 23, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29569850/modeling-of-the-weight-status-and-risk-of-nonalcoholic-fatty-liver-disease-in-elderly-individuals-the-potential-impact-of-the-disulfide-bond-forming-oxidoreductase-a-like-protein-dsba-l-polymorphism-on-the-weight-status
#10
Kentaro Oniki, Takehisa Watanabe, Miku Kudo, Tomoko Izuka, Tatsumasa Ono, Kazuki Matsuda, Yuki Sakamoto, Katsuya Nagaoka, Tadashi Imafuku, Yu Ishima, Hiroshi Watanabe, Toru Maruyama, Koji Otake, Yasuhiro Ogata, Junji Saruwatari
Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity. Disulfide bond-forming oxidoreductase A-like protein (DsbA-L) is known to be a key molecule in protection against obesity and obesity-induced inflammation. In the present study, we used a modeling and simulation approach in an attempt to develop body mass index (BMI) and BMI-based NAFLD prediction models incorporating the DsbA-L polymorphism to predict the BMI and NAFLD in 341 elderly subjects. A nonlinear mixed-effect model best represented the sigmoidal relationship between the BMI and the logit function of the probability of NAFLD prevalence...
March 23, 2018: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29534839/promoter-hypomethylation-of-ski-in-autoimmune-pancreatitis
#11
Yasuhiro Kinugawa, Takeshi Uehara, Kazuyuki Matsuda, Yukihiro Kobayashi, Tomoyuki Nakajima, Hideaki Hamano, Shigeyuki Kawa, Kayoko Higuchi, Noriko Hosaka, Satoshi Shiozawa, Hiroki Ishigame, Toshitsugu Nakamura, Yasuhiro Maruyama, Koh Nakazawa, Masato Nakaguro, Kenji Sano, Hiroyoshi Ota
The relationship between methylation abnormality and autoimmune pancreatitis (AIP)-a representative IgG4-related disease-has not yet been elucidated. We identified SKI might have a significant methylation abnormality in AIP through methylation array analysis using the Illumina Infinium Human Methylation 450K BeadChip array, and investigated the relationship of SKI with AIP clinicopathological features. The methylation rate of SKI was assessed by quantitative SYBR green methylation-specific PCR, and the degree of SKI expression in tissue specimens was assessed by immunohistochemistry in 10 AIP cases, 14 cases of obstructive pancreatitis area in pancreatic ductal adenocarcinoma (PDA) without a history of AIP, and 9 normal pancreas (NP) cases...
April 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29522936/evaluation-of-dna-ploidy-with-intraoperative-flow-cytometry-may-predict-long-term-survival-of-patients-with-supratentorial-low-grade-gliomas-analysis-of-102-cases
#12
Akane Suzuki, Takashi Maruyama, Masayuki Nitta, Takashi Komori, Soko Ikuta, Mikhail Chernov, Manabu Tamura, Takakazu Kawamata, Yoshihiro Muragaki
OBJECTIVE: The objective of the present study was evaluation of the prognostic significance of DNA ploidy assessed with intraoperative flow cytometry (iFC) during resection of low-grade gliomas (LGG). PATIENTS AND METHODS: Retrospective analysis of 102 consecutive cases of newly diagnosed WHO grade II supratentorial gliomas, surgical removal of which was accompanied by iFC, was done. There were 46 diffuse astrocytomas (DA) and 56 oligodendrogliomas (OD). According to iFC, 68 tumors (67%) were considered non-aneuploid and 34 (33%) aneuploid...
May 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29511130/desirable-low-density-lipoprotein-cholesterol-levels-for-preventing-stroke-recurrence-a-post-hoc-analysis-of-the-j-stars-study-japan-statin-treatment-against-recurrent-stroke
#13
Naohisa Hosomi, Kazuo Kitagawa, Yoji Nagai, Yoko Nakagawa, Shiro Aoki, Tomohisa Nezu, Tatsuo Kagimura, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masayasu Matsumoto
BACKGROUND AND PURPOSE: To define desirable target low-density lipoprotein (LDL) cholesterol levels for the prevention of stroke recurrence, a post hoc analysis was performed in the J-STARS study (Japan Statin Treatment Against Recurrent Stroke). METHODS: Subjects (n=1578) were divided into groups based on mean value of postrandomized LDL cholesterol levels until the last observation in 20 mg/dL increments. Adjusted hazard ratios (HRs) and 95% confidence intervals were analyzed for each group, with adjustments for baseline LDL cholesterol, baseline body mass index, hypertension, diabetes mellitus, and statin usage...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29503373/-dietary-approach-to-improving-the-nutritional-status-in-institutionalized-elderly-hemodialysis-patients-with-a-poor-dietary-intake-a-single-arm-pilot-study
#14
Makiko Yamashita, Rieko Komatsu, Yuko Maruyama, Tomoyuki Takaki, Hiroshi Ichinose, Osamu Sasaki, Kenji Sawase, Takashi Harada, Satoshi Funakoshi
OBJECTIVE: The hemodialysis (HD) diet, which is a high-calorie and high-fat regimen, may inadvertently lead to an inadequate dietary intake, resulting in undernutrition among elderly HD patients. Therefore, an attempt was made to improve the dietary intake by implementing a modified diet regimen in eligible elderly HD patients. SUBJECTS: Elderly HD patients who had ingested < 50% of the meals provided and were diagnosed with undernutrition among all elderly patients institutionalized at the special elderly nursing home annexed to Nagasaki Kidney Hospital between June and November 2012...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29472086/image-quality-of-four-dimensional-cone-beam-computed-tomography-obtained-at-various-gantry-rotation-speeds-for-liver-stereotactic-body-radiation-therapy-with-fiducial-markers
#15
Yoshinobu Shimohigashi, Fujio Araki, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Ryo Toya
In this study, qualities of 4D cone-beam CT (CBCT) images obtained using various gantry rotation speeds (GRSs) for liver stereotactic body radiation therapy (SBRT) with fiducial markers were quantitatively evaluated. Abdominal phantom containing a fiducial marker was moved along a sinusoidal waveform, and 4D-CBCT images were acquired with GRSs of 50-200° min-1 . We obtained the 4D-CBCT projection data from six patients who underwent liver SBRT and generated 4D-CBCT images at GRSs of 67-200° min-1 , by varying the number of projection data points...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29462515/risk-factor-for-diabetes-mellitus-and-high-blood-glucose-with-hmg-coa-reductase-inhibitors-using-a-postmarketing-surveillance-database-in-japan
#16
Masayuki Hashiguchi, Junya Maruyama, Mikiko Shimizu, Daichi Takahashi, Tsuyoshi Shiga
To investigate whether 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statin) use is associated with an increased risk of diabetes mellitus and hyperglycemia, we performed a nested case-control study using a postmarketing surveillance database in Japan. The database cohort included 26,849 cases of statin use and 5308 cases of other lipid-lowering drug use in patients with hyperlipidemia. Participants received at least 1 type of statin, had a clear medication history of statin use, and had no complications of diabetes mellitus...
February 20, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29446092/association-of-salivary-lactate-dehydrogenase-level-with-systemic-inflammation-in-a-japanese-population
#17
N Miyoshi, T Tanigawa, S Nishioka, K Maruyama, E Eguchi, K Tanaka, I Saito, K Yamazaki, Y Miyake
BACKGROUND AND OBJECTIVE: Salivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross-sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C-reactive protein (hs-CRP) levels in a community-based middle-aged and elderly population in Japan...
February 15, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29442800/characterization-of-articaine-loaded-poly-%C3%AE%C2%B5-caprolactone-nanocapsules-and-solid-lipid-nanoparticles-in-hydrogels-for-topical-formulations
#18
Nathalie Ferreira Silva de Melo, Estefânia Vangelie Ramos Campos, Michelle Franz-Montan, Eneida de Paula, Camila Morais Gonçalves da Silva, Cíntia Rodrigues Maruyama, Tatiane Pasquoto Stigliani, Renata de Lima, Daniele Ribeiro de Araújo, Leonardo Fernandes Fraceto
This work describes the development of poly-ε-caprolactone nanocapsules (PCL-NC) and solid lipid nanoparticles (SLN) aiming delivery for articaine (ATC), in order to improve its chemical stability in semi-solid preparations looking forward their use for skin delivery. The nanoparticles were characterized by size, polydispersity index, and pH. Cellular viability was evaluated using the MTT test and the in vitro release kinetics was determined using a two-compartment model. The hydrogels with nanoparticle suspensions were characterized considering their rheological aspects and in vitro permeation across artificial membranes...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29435809/body-mass-index-predicts-insulin-sensitivity-during-cardiac-surgery-a-prospective-observational-study
#19
Yosuke Nakadate, Hiroaki Sato, Tamaki Sato, Takumi Codere-Maruyama, Takashi Matsukawa, Thomas Schricker
PURPOSE: Taking into account the previously described link between body weight and diabetes mellitus (DM) in non-surgical patients, and the understanding that the degree of intraoperative insulin resistance is a predictor of adverse clinical outcomes, we investigated the relationship between body mass index (BMI) and insulin sensitivity during cardiac surgery. METHODS: We prospectively enrolled 400 patients scheduled for elective cardiac surgery and divided them into groups based on the presence or absence of type-2 DM...
May 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29399105/health-related-quality-of-life-on-the-clinical-course-of-patients-with-chronic-hepatitis-c-receiving-daclatasvir-asunaprevir-therapy-a-prospective-observational-study-comparing-younger-70-and-elderly-%C3%A2-70-patients
#20
Kazuki Ohashi, Toru Ishikawa, Mitsuyuki Suzuki, Hiroko Abe, Fujiko Koyama, Tomomi Nakano, Aya Ueki, Hirohito Noguchi, Erina Hasegawa, Shiori Hirosawa, Miki Kobayashi, Hiroshi Hirosawa, Kaede Sato, Takako Fukazawa, Yuka Maruyama, Toshiaki Yoshida
Interferon-free direct acting antiviral agent regimens for chronic hepatitis C (CHC) have been developed. These regimens have shown a high rate of sustained virologic response (SVR), and a reduction in side effects during treatment is also anticipated. However, the impact of the regimens on health-related quality of life (HRQOL) and side effects during treatment is not fully understood. The purpose of the present study was to evaluate HRQOL in the clinical course of patients with CHC receiving daclatasvir/asunaprevir (DCV/ASV) therapy using the Short Form-36 (SF-36) method...
January 2018: Experimental and Therapeutic Medicine
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