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https://www.readbyqxmd.com/read/28917830/al-awadi-raas-rothschild-syndrome-with-dental-anomalies-and-a-novel-wnt7a-mutation
#1
Piranit Nik Kantaputra, Seema Kapoor, Prashant Verma, Massupa Kaewgahya, Katsushige Kawasaki, Atsushi Ohazama, James R Ketudat Cairns
Al-Awadi-Raas-Rothschild syndrome (AARRS; OMIM 276820) is a very rare autosomal recessive limb malformation syndrome caused by WNT7A mutations. AARRS is characterized by various degrees of limb aplasia and hypoplasia. Normal intelligence and malformations of urogenital system are frequent findings. Complete loss of WNT7A function has been shown to cause AARRS, however, its partial loss leads to the milder malformation, Fuhrmann syndrome. An Indian boy affected with AARRS is reported. A novel homozygous base substitution mutation c...
September 13, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28917577/direct-pulp-capping-with-calcium-hydroxide-mineral-trioxide-aggregate-and-biodentine-in%C3%A2-permanent-young-teeth-with-caries-a%C3%A2-randomized-clinical-trial
#2
Claudia Brizuela, Andrea Ormeño, Carolina Cabrera, Roxana Cabezas, Carolina Inostroza Silva, Valeria Ramírez, Montse Mercade
INTRODUCTION: Direct pulp capping treatment is intended to preserve pulp vitality, to avoid or retard root canal treatment, and, in cases with an open apex, to allow continued root development. Historically, calcium hydroxide (CH) was the gold standard material, but nowadays calcium silicate materials (CSMs) are displacing CH because of their high bioactivity, biocompatibility, sealing ability, and mechanical properties. However, more randomized clinical trials are needed to confirm the appropriateness of CSMs as replacement materials for CH in direct pulp capping procedures...
September 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28914251/clinical-and-radiographic-comparison-of-platelet-rich-fibrin-and-mineral-trioxide-aggregate-as-pulpotomy-agents-in-primary-molars
#3
Surendra Patidar, Namita Kalra, Amit Khatri, Rishi Tyagi
AIM: This study aimed to evaluate and compare the Platelet-rich fibrin (PRF) and Mineral trioxide aggregate (MTA) as a pulpotomy agent in primary molars. MATERIAL AND METHODS: In this study, 50 primary molars from 50 healthy children aged 5-9 years requiring pulpotomy were randomly allocated into two groups. In PRF group, after coronal pulp removal and hemostasis, remaining pulp tissue was covered with PRF preparation. In the MTA group, the pulp stumps were covered with MTA (Pro Root MTA-Root Canal Repair Material, Dentsply International Inc...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28905239/expression-and-distribution-of-three-transient-receptor-potential-vanilloid-trpv-channel-proteins-in-human-odontoblast-like-cells
#4
Wen Wen, Kehua Que, Chengcheng Zang, Jing Wen, Guangxu Sun, Zhiying Zhao, Yanzhong Li
Odontoblasts have been suggested to contribute to nociceptive sensation in the tooth via expression of the transient receptor potential (TRP) channels. The TRP channels as a family of nonselective cation permeable channels play an important role in sensory transduction of human. In this study, we examined the expression of transient receptor potential vanilloid-1 (TRPV1), transient receptor potential vanilloid-2 (TRPV2) and transient receptor potential vanilloid-3 (TRPV3) channels in native human odontoblasts (HODs) and long-term cultured human dental pulp cells with odontoblast phenotyoe (LHOPs) obtained from healthy wisdom teeth with the use of immunohistochemistry (IHC), immunofluorescence (IF), quantitative real-time polymerase chain reaction (qRT-PCR),western blotting (WB) and immunoelectron microscopy (IEM) assay...
September 13, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28901252/the-origin-and-identification-of-mesenchymal-stem-cells-in-teeth-from-odontogenic-to-non-odontogenic
#5
Dixin Cui, Hongyu Li, Mian Wan, Yiran Peng, Xin Xu, Xuedong Zhou, Liwei Zheng
Mesenchymal stem cells (MSCs) in teeth have been exploited as vital seed cells for stem cell-based dental medicine. To date, several mesenchymal stem cell populations originated from odontogenic tissue have been isolated and characterized by their expression of MSC surface markers and capacity of multi-lineage differentiation, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP) and so on. However, their identity in vivo remains elusive, which hinders further understanding of their application in stem cell-based tooth regeneration...
September 13, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28900213/copine-7-binds-to-the-cell-surface-receptor-nucleolin-and-regulates-ciliogenesis-and-dspp-expression-during-odontoblast-differentiation
#6
You-Mi Seo, Su-Jin Park, Hye-Kyung Lee, Joo-Cheol Park
Tooth development is a progressive process regulated by interactions between epithelial and mesenchymal tissues. Our previous studies showed that copine-7 (Cpne7), a dental epithelium-derived protein, is a signalling molecule that is secreted by preameloblasts and regulates the differentiation of preodontoblasts into odontoblasts. However, the mechanisms involved in the translocation of Cpne7 from preameloblasts to preodontoblasts and the functions of Cpne7 during odontogenesis are poorly understood. Here, we showed that the internalization of Cpne7 was mediated primarily by caveolae...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894386/oxidative-stress-in-patients-with-endodontic-pathologies
#7
Veiko Vengerfeldt, Reet Mändar, Mare Saag, Anneli Piir, Tiiu Kullisaar
BACKGROUND: Apical periodontitis (AP) is an inflammatory disease affecting periradicular tissues. It is a widespread condition but its etiopathogenetic mechanisms have not been completely elucidated and the current treatment options are not always successful. PURPOSE: To compare oxidative stress (OxS) levels in the saliva and the endodontium (root canal [RC] contents) in patients with different endodontic pathologies and in endodontically healthy subjects. PATIENTS AND METHODS: The study group of this comparison study included 22 subjects with primary chronic apical periodontitis (pCAP), 26 with posttreatment or secondary chronic apical periodontitis (sCAP), eight with acute periapical abscess, 13 with irreversible pulpitis, and 17 healthy controls...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28893042/clinical-assessment-of-various-obturating-techniques-for-primary-teeth-a-comparative-study
#8
Mahima Gandhi, Sandeep Tandon, Akshat Vijay, Garima Kalia, Khushboo Rathore
INTRODUCTION: Lifelong preservation of tooth in a healthy state is the ultimate goal of dentistry. Premature loss of primary teeth is common due to caries, dental trauma or other causes. As the primary teeth are the best space maintainers, teeth with infected pulps should be retained until exfoliation, whenever possible. AIM: The purpose of this in vivo study was to evaluate and compare the efficacy of different obturating methods used in primary teeth. MATERIALS AND METHODS: Forty one patients aged four to nine years with a total of 60 teeth were selected...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890616/clinical-and-practical-implications-of-storage-media-used-for-tooth-avulsion
#9
REVIEW
Vineet Is Khinda, Gurpreet Kaur, Gurlal S Brar, Shiminder Kallar, Heena Khurana
Replantation is being widely accepted as an effective treatment option for an avulsed tooth. However, the long-term fate of replanted teeth is unpredictable; it is dependent on various factors, such as the time interval between avulsion and replantation, extra-alveolar storage period (dry storage or storage media), the vitality status of pulp or periodontal tissues and the type and period of splinting. The appropriate use of storage media is an important clinical factor affecting the postoperative prognosis of avulsed teeth following replantation...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28890610/evaluation-of-novel-glass-fiber-reinforced-composite-technique-for-primary-anterior-teeth-with-deep-carious-lesions-a-12-month-clinical-study
#10
Ajinkya Sawant, Yusuf Chunawalla, Abdul Morawala, Nupur S Kanchan, Kapil Jain, Rohan Talathi
BACKGROUND: Early childhood caries discloses a distinct clinical pattern, and the teeth most often involved are the maxillary central incisors, lateral incisors, and the maxillary and man-dibular first molars. The maxillary incisors are most severely affected, with deep carious lesions usually involving the pulp. Teeth that have been endodontically treated often have little coronal tooth tissue remaining and as such require a post to retain the core and restoration .This study evaluated and compared the efficacy of EverStick glass fiber-reinforced composite post with ParaPost Taper Lux in primary maxillary anterior teeth...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28888395/dental-adaptations-of-bronze-age-harappans-occlusal-wear-crown-size-and-dental-pathology
#11
John R Lukacs
Systematic study of dental attributes yields insights regarding diet and subsistence that cannot be gained from the archaeological record alone. This analysis documents occlusal tooth wear, tooth crown dimensions and dental pathology of an expanded dental sample from Harappa (2550-2030cal BC; Pakistan). New floral and faunal evidence of subsistence indicates a mix of agriculture and pastoralism that can be integrated with evidence of dental attributes and disease to reveal the impact of Harappan diet on oral health...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28886764/advanced-scaffolds-for-dental-pulp-and-periodontal-regeneration
#12
REVIEW
Marco C Bottino, Divya Pankajakshan, Jacques E Nör
No current therapy promotes root canal disinfection and regeneration of the pulp-dentin complex in cases of pulp necrosis. Antibiotic pastes used to eradicate canal infection negatively affect stem cell survival. Three-dimensional easy-to-fit antibiotic-eluting nanofibers, combined with injectable scaffolds, enriched or not with stem cells and/or growth factors, may increase the likelihood of achieving predictable dental pulp regeneration. Periodontitis is an aggressive disease that impairs the integrity of tooth-supporting structures and may lead to tooth loss...
October 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28886763/bioactive-dental-composites-and-bonding-agents-having-remineralizing-and-antibacterial-characteristics
#13
REVIEW
Ke Zhang, Ning Zhang, Michael D Weir, Mark A Reynolds, Yuxing Bai, Hockin H K Xu
Current dental restorative materials are typically inert and replace missing tooth structures. This article reviews efforts in the development of a new generation of bioactive materials designed to not only replace the missing tooth volume but also possess therapeutic functions. Composites and bonding agents with remineralizing and antibacterial characteristics have shown promise in replacing lost minerals, inhibiting recurrent caries, neutralizing acids, repelling proteins, and suppressing biofilms and acid production...
October 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28886584/human-pulpal-blood-flow-in-different-root-formation-stages-measured-with-transmitted-light-plethysmography
#14
Khongorzul Ganbold, Satoko Kakino, Hideharu Ikeda, Michiyo Miyashin
OBJECTIVES: To determine the pulp vitality after traumatic injury, dentists often use pulp sensitivity tests, which can be ambiguous in young permanent teeth with incomplete root formation. Transmitted-light plethysmography (TLP) is a non-invasive objective method that uses a 525-nm LED to detect blood volume change in the pulp. The present study aimed (1) to investigate pulpal blood flow with TLP and optical characteristics in healthy permanent maxillary incisors in different root formation stages, and (2) to assess the influences of body growth of the children and tooth color on the TLP amplitude...
August 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28877285/chondroblastic-osteosarcoma-mimicking-periapical-abscess
#15
Fernanda Paula Yamamoto-Silva, Brunno Santos de Freitas Silva, Aline Carvalho Batista, Elismauro Francisco de Mendonça, Décio Dos Santos Pinto-Júnior, Carlos Estrela
Case report: The present report describes a case of chondroblastic osteosarcoma in the periapical region of teeth #29, #30, and #31 of an 18-year-old male. Clinical history showed self-reported discomfort in the right posterior gingiva for over a month. Physical examination showed a small expansion and redness of the right mandibular buccal and lingual cortical plates, but no signs of pain or inflammation were observed. All the teeth responded positively to pulp sensibility. Periapical and panoramic radiographs showed slight periapical radiolucency in the roots of teeth #29 and #30, clear periodontal ligament space widening, and evident loss of lamina dura...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28874649/quantitative-assessment-of-apically-extruded-bacteria-using-different-instrumentation-techniques-and-preparation-taper
#16
Harsh Priyank, Vinisha Pandey, Achla Sethi, Vinay J Sharma, Harleen Bali, Ramandeep S Punia
BACKGROUND: Cleaning and shaping of the pulp canal is one of the most important steps of endodontic therapy. Serious complications occur by the apical extrusion of bacteria during the instrumentation procedures. Both crown-down (CD) and full-length linear motion (FM) techniques are routinely used as a component of taper rotary instrument procedures for achievement of thorough cleaning and shaping of the pulp canal space. Hence, we aimed for this study to assess the change in the amount of apically extruded bacteria using CD and FM instrumentation techniques produced by differences in taper between the instruments used during biomechanical preparation of root canals...
September 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28864218/the-association-between-the-anatomic-landmarks-of-the-pulp-chamber-floor-and-the-prevalence-of-middle-mesial-canals-in-mandibular-first-molars-an-in%C3%A2-vivo-analysis
#17
Navid Akbarzadeh, Anita Aminoshariae, Navid Khalighinejad, J Martin Palomo, Syed Ali, James C Kulild, Ghazal Sadeghi, Andre Mickel
INTRODUCTION: The present study aimed to determine the incidence and anatomic variation of the middle mesial (MM) canal in mandibular permanent first molars using cone-beam computed tomographic imaging and to evaluate the association between the presence of MM canals and anatomic landmarks of the pulp chamber floor in the mesial root. METHODS: In this in vivo cross-sectional study, 210 CBCT scans of mandibular fist molars from 210 patients were included. CBCT scans were evaluated in 3 sections, and the following data were collected for further analysis: identification of the MM canal, the distance between the mesiobuccal (MB) and mesiolingual (ML) orifices, the presence of any isthmus between the MB and ML orifices, and the MB and ML root canal system (RCS) configurations...
August 29, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28853497/-vital-pulp-therapy-of-damaged-dental-pulp
#18
Zhou Xuedong, Huang Dingming, Liu Jianguo, Huang Zhengwei, Wei Xin, Yang Deqin, Zhao Jin, Chen Liming, Zhu Lin, Li Yanhong, Li Jiyao
The development of an expert consensus on vital pulp therapy can provide practical guidance for the improvement of pulp damage care in China. Dental pulp disease is a major type of illness that adversely affects human oral health. Pulp capping and pulpotomy are currently the main methods for vital pulp therapy. Along with the development of minimal invasion cosmetic dentistry, using different treatment technologies and materials reasonably, preserving healthy tooth tissue, and extending tooth save time have become urgent problems that call for immediate solution in dental clinics...
August 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28852632/incidence-of-endodontic-flare-ups-and-its-related-factors-a-retrospective-study
#19
Manuja Nair, J Rahul, A Devadathan, Josey Mathew
AIMS AND OBJECTIVES: The aim and objective of the study were to determine the incidence of flare-ups during endodontic treatment and to identify the risk factors associated with flare-ups. SUBJECTS AND METHODS: A total of 1725 patients who were treated during the time period of 2009-2014 by the same endodontist were reviewed. Incidence of flare-up, patients' age, gender, status of pulp, tooth position, number of roots, and treatment provided were taken from their dental records...
July 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28844309/microbial-modulation-of-stem-cells-and-future-directions-in-regenerative-endodontics
#20
Anibal Diogenes, Kenneth M Hargreaves
Regenerative endodontic procedures (REPs) have been shown to promote the resolution of signs and symptoms of disease and increase survival compared with traditional treatment procedures. However, there is still variable predictability of continued root development and evidence that the tissues formed do not recapitulate the native pulp-dentin complex. There is growing evidence that the apical papilla is capable of surviving prolonged endodontic infection and apical periodontitis and that it represents a rich source of undifferentiated mesenchymal stem cells in REPs...
September 2017: Journal of Endodontics
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