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https://www.readbyqxmd.com/read/29770323/dental-mesenchymal-stem-cell-based-translational-regenerative-dentistry-from-artificial-to-biological-replacement
#1
REVIEW
Mona K Marei, Rania M El Backly
Dentistry is a continuously changing field that has witnessed much advancement in the past century. Prosthodontics is that branch of dentistry that deals with replacing missing teeth using either fixed or removable appliances in an attempt to simulate natural tooth function. Although such "replacement therapies" appear to be easy and economic they fall short of ever coming close to their natural counterparts. Complications that arise often lead to failures and frequent repairs of such devices which seldom allow true physiological function of dental and oral-maxillofacial tissues...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29763356/chairside-cad-cam-composite-onlays-for-the-restoration-of-primary-molars
#2
Elisabeth Dursun, Aude Monnier-Da Costa, Christian Moussally
After pulp therapy or with multi-surface caries in primary molars, pre-formed stainless steel crowns are usually placed to ensure tooth longevity. Esthetic alternatives, such as zirconia crowns, have been proposed, but they are invasive. Here we describe two cases of chairside computer-aided design and computer-aided manufacturing (CAD/CAM) technology used to treat extended and/or deep caries on primary molars. A powder-free chairside CAD/CAM system, a milling unit and machinable high-performance composite blocks were used...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29763345/tissue-engineering-of-necrotic-dental-pulp-of-immature-teeth-with-apical-periodontitis-in-dogs-radiographic-and-histological-evaluation
#3
Eman A El Ashiry, Najlaa M Alamoudi, Mahmoud K El Ashiry, Hagar A Bastawy, Douaa A El Derwi, Hazem M Atta
AIM: To evaluate tissue engineering technology to regenerate pulp-dentin like tissues in pulp canals of immature necrotic permanent teeth with apical periodontitis in dogs. STUDY DESIGN: The study was performed on 36 teeth in 12 dogs. The experiment was carried out using split mouth design. In each dog 3 teeth were selected for implementing the study procedure. Apical periodontitis was induced in Group A and B teeth. Group (A): immature upper left 2nd permanent incisors that were transplanted with a construct of autologous dental pulp stem cells with growth factors seeded in a chitosn hydrogel scaffold...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29758290/proteome-response-of-dental-pulp-cells-to-exogenous-fgf8
#4
Rozaliya Tsikandelova, Petko Mladenov, Sébastien Planchon, Silvia Kalenderova, Maria Dragneva, Zornitsa Mihaylova, Pavel Stanimirov, Vanyo Mitev, Jenny Renaut, Nikolay Ishkitiev
FGF8 specifies early tooth development by directing the migration of the early tooth founder cells to the site of tooth emergence. To date the effect of the FGF8 in adult dental pulp has not been studied. We have assessed the regenerative potential of FGF8 by evaluating changes in the proteome landscape of dental pulp following short- and long-term exposure to recombinant FGF8 protein. In addition, we carried out qRT PCR analysis to determine extracellular/adhesion gene marker expression and assessed cell proliferation and mineralization in response to FGF8 treatment...
May 11, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29752201/maxillary-tooth-growth-in-the-adult-male-babirusa-genus-babyrousa
#5
Alastair A Macdonald, Darren J Shaw
The growth of the maxillary canine teeth of the babirusa (genus Babyrousa) was studied on a sample of 149 adult male babirusa skulls from twenty-two international museum and private collections. Skulls from Buru, Sulawesi and the Togian Islands were represented. The continuous growth process was summarised into five stages ('A'-'E') according to the position of the tip of the tooth over the bones of the skull. The supracutaneous portion of the tooth grew in a curve-linear fashion dorso-caudally, and was orientated such that the tips grew towards the midline of the cranium...
May 8, 2018: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29737544/external-cervical-resorption-part-2-management
#6
REVIEW
S Patel, F Foschi, R Condon, T Pimentel, B Bhuva
Effective management of external cervical resorption (ECR) depends on accurate assessment of the true nature and accessibility of ECR; this has been discussed in part 1 of this 2 part paper. This aim of this paper is firstly, to review the literature in relation to the management of ECR, and secondly, based on the available evidence describe different strategies for the management of ECR. In cases where ECR is supracrestal, superficial and with limited circumferential spread a surgical repair without root canal treatment is the preferred approach...
May 8, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29737458/dental-pulp-stem-cells-exploration-in-a-novel-animal-model-the-tasmanian-devil-sarcophilus-harrisii
#7
REVIEW
Chelsea M Graham, Karlea L Kremer, Simon A Koblar, Monica A Hamilton-Bruce, Stephen B Pyecroft
Dental pulp stem cells (DPSC) are a heterogeneous population of highly proliferative stem cells located in the soft inner pulp tissue of the tooth. Demonstrated to have an affinity for neural differentiation, DPSC have been reported to generate functional Schwann cells (SC) through in vitro differentiation. Both DPSC and SC have neural crest origins, recently a significant population of DPSC have been reported to derive from peripheral nerve-associated glia. The predisposition DPSC have towards the SC lineage is not only a very useful tool for neural regenerative therapies in the medical field, it also holds great promise in the veterinary field...
May 8, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29734801/regenerative-endodontics-after-front-tooth-trauma-a-case-report
#8
Renzo Bassetti, Johannes Kuttenberger, Mario Bassetti
In the context of tooth trauma, mostly the maxillary central front teeth are involved, whereby their roots are in some cases still in the developing stage (immature). Depending on the type of trauma, a necrosis of the pulp is the consequence or at least foreseeable. In order to preserve such a tooth, an endodontic therapy is inevitable. The disadvantage of conventional endodontic therapy methods of immature teeth (apexification, apexogenesis) is the root growth stop. Alternatively, the regeneration/revascularisation of the dental pulp (RP) was suggested, that allows a further root growth...
May 14, 2018: Swiss Dental Journal
https://www.readbyqxmd.com/read/29719935/prognosis-and-complications-of-immature-teeth-following-lateral-luxation-a-systematic-review
#9
Danielle Clark, Liran Levin
BACKGROUND/AIMS: Lateral luxation injuries are a type of traumatic dental injury in which the tooth becomes displaced in the palatal/lingual or labial direction. This injury is common amongst children and can result in pulp canal obliteration or pulp necrosis. The objective of this systematic review was to gather existing data on lateral luxation injuries to immature teeth to evaluate their overall prognosis. METHODS: A systematic search was conducted using Medline, Pubmed, Scopus, Lilacs, EMBASE and Cochrane databases in October 2017...
May 2, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29707014/thermal-scanning-of-dental-pulp-chamber-by-thermocouple-system-and-infrared-camera-during-photo-curing-of-resin-composites
#10
Faeze Hamze, Seyed Abdolreza Ganjalikhan Nasab, Ali Eskandarizadeh, Arash Shahravan, Fatemeh Akhavan Fard, Neda Sinaee
Introduction: Due to thermal hazard during composite restorations, this study was designed to scan the pulp temperature by thermocouple and infrared camera during photo polymerizing different composites. Methods and Materials: A mesio-occlso-distal (MOD) cavity was prepared in an extracted tooth and the K-type thermocouple was fixed in its pulp chamber. Subsequently, 1 mm increment of each composites were inserted (four composite types were incorporated) and photo polymerized employing either LED or QTH systems for 60 sec while the temperature was recorded with 10 sec intervals...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29703239/allogeneic-transplantation-of-mobilized-dental-pulp-stem-cells-with-the-mismatched-dog-leukocyte-antigen-type-is-safe-and-efficacious-for-total-pulp-regeneration
#11
Koichiro Iohara, Shinji Utsunomiya, Sakae Kohara, Misako Nakashima
BACKGROUND: We recently demonstrated that autologous transplantation of mobilized dental pulp stem cells (MDPSCs) was a safe and efficacious potential therapy for total pulp regeneration in a clinical study. The autologous MDPSCs, however, have some limitations to overcome, such as limited availability of discarded teeth from older patients. In the present study, we investigated whether MDPSCs can be used for allogeneic applications to expand their therapeutic use. METHODS: Analysis of dog leukocyte antigen (DLA) was performed using polymerase chain reaction from blood...
April 27, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29702010/pulp-regeneration-by-3-dimensional-dental-pulp-stem-cell-constructs
#12
Y Itoh, J I Sasaki, M Hashimoto, C Katata, M Hayashi, S Imazato
Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk of inflammation and infection. To establish a basic technology for novel dental pulp regenerative therapy that allows transplant of pulp-like tissue, we attempted to fabricate scaffold-free 3-dimensional (3D) cell constructs composed of dental pulp stem cells (DPSCs)...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29697396/influence-of-tricalcium-silicate-on-course-of-traumatic-pulpitis
#13
I Kovach, K Buniatian, A Makarevych, A Verbyts'ka, V Gargin
The use of Tricalcium Silicate (TS) as an odontotropic preparation makes it possible to create a hermetic crown restoration with a high degree of adhesion. However, the use of TS silicate by direct pulp capping remains disputable. The aim of this study was to determine the effects of TS on course of traumatic pulpitis by detection of morpho-functional peculiarities of changes in pulp tissue. We performed experimental investigation (on rabbits, males, aging three-month) for study of the morpho-functional changes of the pulp tissues with modeling of traumatic pulpitis and direct pulp capping with TS preparation (8 animals, investigated group) and calcium hydroxide (Calasept, NORDISKA DENTAL) preparation (8 animals, comparison group)...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29694352/effects-of-loxoprofen-on-the-apical-root-resorption-during-orthodontic-tooth-movement-in-rats
#14
Taeko Yamamoto, Masato Kaku, Hiromi Sumi, Yuka Yashima, Jin Izumino, Kotaro Tanimoto
Studies have revealed that severe apical root resorption during tooth movement is caused by the noninfective inflammatory reaction of apical root tissues. We hypothesized that loxoprofen can suppress apical root resorption during tooth movement. Cyclic tensile force (CTF) of 10 kPa was applied to the human pulp cells for 48 hours by the Flexcell Strain Unit. Loxoprofen (10 and 100 μM) was added to the culture cells, and expression of cyclooxygenase (COX)-1, COX-2, interleukin (IL)-1β, receptor activator of nuclear factor kappa-B ligand (RANKL), tumor necrosis factor (TNF)-α, and macrophage colony-stimulating factor (M-CSF) were examined...
2018: PloS One
https://www.readbyqxmd.com/read/29692834/expression-of-osteoprotegrin-and-osteoclast-level-in-chronic-apical-periodontitis-induced-with-east-java-propolis-extract
#15
Tamara Yuanita, Nanik Zubaidah, Sri Kunarti
Introduction: The objective of this animal study was to promote East Java propolis as a potential natural intracanal medicament for periapical chronic apical periodontitis bone resorption through evaluating the expression of osteoprotegrin (OPG) and osteoclast level. Methods and Materials: Propolis extract was produced using a maceration procedure. Thirty Wistar rats were divided into three groups. In group I, the control group, the first upper right molar constituted a healthy tooth...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29692829/comparison-of-postoperative-pain-following-one-visit-and-two-visit-vital-pulpectomy-in-primary-teeth-a-single-blind-randomized-clinical-trial
#16
Elham Farokh-Gisour, Masoud Parirokh, Marjan Kheirmand Parizi, Nouzar Nakhaee, Masoumeh Aminizadeh
Introduction: The aim of this study was to compare post-operative pain following one-visit pulpectomy and placing stainless steel crown (SSC), with two-visit treatment (performing pulpectomy at the first visit followed by placing SSC at the next visit one week later) in vital pulp of primary molars with carious involvement. Methods and Materials: In this randomized clinical trial, 100 children aged 6-12 years with a carious primary molar tooth in need of pulpectomy were randomly divided into two groups of 50 each...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29691571/-case-based-learning-based-on-cbct-software-in-clinical-teaching-of-oral-and-maxillofacial-radiology
#17
Ling Zhu, Xia Cao, Xiao-Feng Tao
PURPOSE: To compare the teaching result of case-based learning based on cone-beam CT (CBCT) software and traditional pantomography. METHODS: Thirty-eight interns (7-year programme) of grade 2011 from College of Stomatology, Shanghai Jiao Tong University were enrolled. The inner diameter of the nasopalatine ducts (A), the length of upper canine's pulp cavity (B), the length between root furcation of upper first molar and the maxillary sinus (C), the length between the root of lower wisdom tooth and the inferior alveolar nerve (D) were measured on pantomographic films and CBCT in the same case...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29681479/full-pulpotomy-with-biodentine-in-symptomatic-young-permanent-teeth-with-carious-exposure
#18
Nessrin A Taha, Sakhaa Z Abdulkhader
INTRODUCTION: This prospective study evaluated the outcome of Biodentine (Septodont, Saint Maur des Fosses, France) pulpotomy in young permanent teeth with carious exposure. METHODS: Twenty permanent molar teeth in 14 patients with carious pulp exposure were treated with Biodentine pulpotomy. The age of the patients ranged from 9-17 years (12.3 ± 2.7 years). A preoperative pulpal and periapical diagnosis was established. After informed consent, the tooth was anesthetized, isolated via a dental dam, and disinfected with 5% sodium hypochlorite before caries excavation...
April 19, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29681055/reproducing-the-internal-and-external-anatomy-of-fossil-bones-two-new-automatic-digital-tools
#19
Antonio Profico, Stefan Schlager, Veronica Valoriani, Costantino Buzi, Marina Melchionna, Alessio Veneziano, Pasquale Raia, Jacopo Moggi-Cecchi, Giorgio Manzi
OBJECTIVES: We present two new automatic tools, developed under the R environment, to reproduce the internal and external structures of bony elements. The first method, Computer-Aided Laser Scanner Emulator (CA-LSE), provides the reconstruction of the external portions of a 3D mesh by simulating the action of a laser scanner. The second method, Automatic Segmentation Tool for 3D objects (AST-3D), performs the digital reconstruction of anatomical cavities. MATERIALS AND METHODS: We present the application of CA-LSE and AST-3D methods to different anatomical remains, highly variable in terms of shape, size and structure: a modern human skull, a malleus bone, and a Neanderthal deciduous tooth...
April 21, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29676980/effect-of-bleaching-gel-viscosity-on-tooth-whitening-efficacy-and-pulp-chamber-penetration-an-in-vitro-study
#20
S R Kwon, Fnu Pallavi, Y Shi, U Oyoyo, A Mohraz, Y Li
OBJECTIVES: Whitening efficacy has been related to hydrogen peroxide (HP) diffusion into tooth structure. However, little information is available relating rheological properties to whitening efficacy. The purpose was to evaluate the whitening efficacy and HP penetration level of a 10% HP gel at three different viscosities and to compare them to a strip delivery system. METHODS AND MATERIALS: Extracted molars (n=120) were randomly assigned into five groups (n=24/ group): NC_MED (negative control; median): medium viscosity gel without HP; LOW: 10% HP gel (low viscosity experimental gel, Ultradent Products Inc); MED: 10% HP gel (medium viscosity experimental gel, Ultradent); HIGH: 10% HP gel (high viscosity gel, Ultradent); and CWS: Crest 3D Whitestrips 1-Hour Express (Procter & Gamble)...
May 2018: Operative Dentistry
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