Thomas F Imperiale, Kyle Porter, Julia Zella, Zubin D Gagrat, Marilyn C Olson, Sandi Statz, Jorge Garces, Philip T Lavin, Humberto Aguilar, Don Brinberg, Charles Berkelhammer, John B Kisiel, Paul J Limburg
BACKGROUND: A next-generation multitarget stool DNA test, including assessments of DNA molecular markers and hemoglobin level, was developed to improve the performance of colorectal cancer screening, primarily with regard to specificity. METHODS: In a prospective study, we evaluated a next-generation multitarget stool DNA test in asymptomatic adults 40 years of age or older who were undergoing screening colonoscopy. The primary outcomes were sensitivity of the test for colorectal cancer and specificity for advanced neoplasia (colorectal cancer or advanced precancerous lesions)...
March 14, 2024: New England Journal of Medicine