keyword
https://read.qxmd.com/read/38493289/hematological-parameters-in-patients-with-recurrent-aphthous-stomatitis-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Tahoora Mousavi, Hossein Jalali, Mahmood Moosazadeh
OBJECTIVES: Recurrent Aphthous Stomatitis (RAS) known as recurrent aphthous ulcer is a common and painful ulcerations in oral cavity. It has been suggested that hematological parameters seems to be considered as an etiologic factor. So, this meta-analysis and systematic review was aimed to examine the relationship between RAS and hematological parameters. METHODS: Relevant studies were found using online international databases including Scopus, Science direct, Web of science (ISI), PubMed, and Google Scholar search engine between 2000 and October 2023...
March 16, 2024: BMC Oral Health
https://read.qxmd.com/read/38492740/self-identified-prescriber-tendencies-in-sodium-glucose-cotransporter-2-inhibitor-outpatient-prescribing
#2
JOURNAL ARTICLE
Kristen Thompson, Brandi L Bowers, Ashley M Evans
BACKGROUND: Despite expanded indications and demonstrated cardiovascular and renal benefits, prescribing rates of SGLT-2 inhibitors are low. OBJECTIVES: The study aimed to identify factors impacting prescriber decision-making when prescribing SGLT-2 inhibitors in the outpatient setting and identify differences across specialties in self-identified prescribing patterns. METHODS: An anonymous survey was administered electronically to prescribers in relevant specialties at a large community health system...
March 14, 2024: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/38492130/circulating-bone-morphogenetic-protein-9%C3%A2-bmp9-as-a-new-biomarker-for-noninvasive-stratification-of-nonalcoholic-fatty-liver-disease-and-metabolic-syndrome
#3
JOURNAL ARTICLE
Yuchen Yang, Meihong Gu, Wei Wang, Shan Li, Jinlai Lu, Qinjuan Sun, Miao Hu, Lan Zhong
Nonalcoholic fatty liver disease (NAFLD) is closely related to metabolic syndrome (MetS). Bone morphogenetic protein 9 (BMP9) is an essential factor in glucose, lipid and energy metabolism. This study aims to investigate whether BMP9 can serve as a serological marker for the severity of NAFLD or MetS. Blood samples, clinical data and FibroTouch test were collected from consecutively recruited 263 individuals in Shanghai East hospital. All the participants were divided into three groups: the healthy controls, nonalcoholic fatty liver (NAFL) group and nonalcoholic steatohepatitis (NASH) at-risk group according to the results of FibroTouch test and liver function...
March 16, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38491398/optimizing-the-transfusion-strategy-in-surgical-patients-in-a-lebanese-university-hospital
#4
JOURNAL ARTICLE
Stephanie El Hawat, Rita Saliby, Ghassan Sleilaty, Alain El Asmar, Anthony Ghosn
BACKGROUND AND PURPOSE: Our aim was to analyze factors that influence transfusion requirements in surgical patients in order to achieve a transfusion-saving strategy. METHODS: Data was collected from patient's files at the Notre Dame de Secours-Jbeil University Hospital Center between January 2017 and June 2019. Selection was made for 400 patients who had undergone surgery and required transfusion. The studied variables were age, sex, and type of surgery whether planned or urgent with its expected level of bleeding...
March 15, 2024: Perioperative Medicine
https://read.qxmd.com/read/38490220/is-there-utility-in-preoperative-testing-of-hemoglobin-before-primary-cheiloplasty
#5
JOURNAL ARTICLE
Aryan Shay, Megan Gaffey, Roger Roe, Alexa Robbins, Isabella Zaniletti, Adam Johnson, Larry Hartzell
OBJECTIVE: To examine whether a preoperative hemoglobin of less than 10 g/dL is associated with a higher rate of perioperative complications. DESIGN: Retrospective review. SETTING: Tertiary academic hospital at Arkansas Children's Hospital of Little Rock, Arkansas. PATIENTS: A retrospective chart review evaluated patients undergoing primary cleft lip surgery from 2012 to 2017. INTERVENTIONS: No prospective intervention was performed for this study care...
March 15, 2024: Cleft Palate-craniofacial Journal
https://read.qxmd.com/read/38489692/geriatric-nutritional-risk-index-is-correlated-with-islet-function-but-not-insulin-resistance-in-elderly-patients-with-type-2-diabetes-a-retrospective-study
#6
JOURNAL ARTICLE
Nan Geng, Yaxue Gao, Yuanyuan Ji, Yingchun Niu, Cuijuan Qi, Yunfeng Zhen, Jinhu Chen, Luping Ren
The geriatric nutritional risk index (GNRI) is a simple nutritional assessment tool that can predict poor prognosis in elderly subjects. The aim of this study was to evaluate the association between GNRI and both islet function and insulin sensitivity in patients with type 2 diabetes mellitus. This research carries significant implications for the integrated treatment and nutritional management of this patient population. A total of 173 patients with type 2 diabetes mellitus, aged 60 years or older, who were hospitalized in the Endocrinology Department at Hebei General Hospital from February 2018 to June 2021, were selected as the research subjects...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38487212/cardiometabolic-improvements-after-metabolic-surgery-and-related-presurgery-factors
#7
JOURNAL ARTICLE
Lei Wang, Michael T O'Brien, Xinmeng Zhang, You Chen, Wayne J English, Brandon Williams, Matthew Spann, Vance Albaugh, Xiao-Ou Shu, Charles R Flynn, Danxia Yu
CONTEXT: Metabolic surgery remains the most effective and durable treatment for severe obesity and related metabolic diseases. OBJECTIVE: We examined cardiometabolic improvements after metabolic surgery and associated presurgery demographic and clinical factors in a large multiracial cohort. METHODS: Included were 7804 patients (20-79 years) undergoing first-time metabolic surgery at Vanderbilt University Medical Center from 1999 to 2022. Pre- and 1-year postsurgery cardiometabolic profiles were extracted from medical records, including body mass index (BMI), blood pressure, blood lipids, glucose, and hemoglobin A1c...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38486703/prediction-of-intraoperative-red-blood-cell-transfusion-in-valve-replacement-surgery-machine-learning-algorithm-development-based-on-non-anemic-cohort
#8
JOURNAL ARTICLE
Ren Zhou, Zhaolong Li, Jian Liu, Dewei Qian, Xiangdong Meng, Lichun Guan, Xinxin Sun, Haiqing Li, Min Yu
BACKGROUND: Our study aimed to develop machine learning algorithms capable of predicting red blood cell (RBC) transfusion during valve replacement surgery based on a preoperative dataset of the non-anemic cohort. METHODS: A total of 423 patients who underwent valvular replacement surgery from January 2015 to December 2020 were enrolled. A comprehensive database that incorporated demographic characteristics, clinical conditions, and results of preoperative biochemistry tests was used for establishing the models...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38483938/the-beneficial-effect-of-allium-cepa-bulb-extract-on-reproduction-of-rats-a-two-generation-study-on-fecundity-and-sex-hormones
#9
JOURNAL ARTICLE
Sadia Suri, Saira Saeed Khan, Sadaf Naeem, Zeb Un Nisa, Nausheen Alam, Saba Majeed, Suresh Kumar, Rafeeq Alam Khan
Allium Cepa Linn. (Onions) has extensively been used in traditional medicine, is one of the important Allium species regularly used in our daily diet, and has been the source of robust phenolic compounds. The current study is intended to evaluate the fecundity-enhancing effect of A. Cepa on the reproductive performance of two successive generations of rats; F0 and F1. A. Cepa extract was initially tested for in vitro antioxidant assay via DPPH and ROS, followed by in vivo toxicity testing. In the fecundity assessment, eighteen pairs of male and female rats (n = 36, 1:1, F0 generation) were divided into three groups and dosed with 75mg/kg and 150 mg/kg daily of A...
2024: PloS One
https://read.qxmd.com/read/38481447/predictive-model-and-risk-analysis-for-peripheral-vascular-disease-in-type-2-diabetes-mellitus-patients-using-machine-learning-and-shapley-additive-explanation
#10
JOURNAL ARTICLE
Lianhua Liu, Bo Bi, Li Cao, Mei Gui, Feng Ju
BACKGROUND: Peripheral vascular disease (PVD) is a common complication in patients with type 2 diabetes mellitus (T2DM). Early detection or prediction the risk of developing PVD is important for clinical decision-making. PURPOSE: This study aims to establish and validate PVD risk prediction models and perform risk factor analysis for PVD in patients with T2DM using machine learning and Shapley Additive Explanation(SHAP) based on electronic health records. METHODS: We retrospectively analyzed the data from 4,372 inpatients with diabetes in a hospital between January 1, 2021, and March 28, 2023...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38478194/nomogram-for-predicting-remission-of-metabolic-syndrome-1-year-after-sleeve-gastrectomy-surgery-in-chinese-patients-with-obesity
#11
JOURNAL ARTICLE
Yunhui Pan, Xiaodong Han, Yinfang Tu, Pin Zhang, Haoyong Yu, Yuqian Bao
PURPOSE: Sleeve gastrectomy (SG) is a widely used and effective treatment for patients with obesity and comorbid metabolic abnormalities. No specialized tool is available to predict metabolic syndrome (MS) remission after SG. We presented a nomogram that evaluated the probability of MS remission in obese patients 1 year after SG. MATERIALS AND METHODS: Patients with preoperative MS who underwent SG were enrolled in this retrospective study. They were divided into a training set and a validation set...
March 13, 2024: Obesity Surgery
https://read.qxmd.com/read/38477986/next-generation-multitarget-stool-dna-test-for-colorectal-cancer-screening
#12
JOURNAL ARTICLE
Thomas F Imperiale, Kyle Porter, Julia Zella, Zubin D Gagrat, Marilyn C Olson, Sandi Statz, Jorge Garces, Philip T Lavin, Humberto Aguilar, Don Brinberg, Charles Berkelhammer, John B Kisiel, Paul J Limburg
BACKGROUND: A next-generation multitarget stool DNA test, including assessments of DNA molecular markers and hemoglobin level, was developed to improve the performance of colorectal cancer screening, primarily with regard to specificity. METHODS: In a prospective study, we evaluated a next-generation multitarget stool DNA test in asymptomatic adults 40 years of age or older who were undergoing screening colonoscopy. The primary outcomes were sensitivity of the test for colorectal cancer and specificity for advanced neoplasia (colorectal cancer or advanced precancerous lesions)...
March 14, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38477745/bone-remodeling-and-responsiveness-to-mechanical-stimuli-in-individuals-with-type-1-diabetes-mellitus
#13
JOURNAL ARTICLE
Matthias Walle, Ankita Duseja, Danielle E Whittier, Tatiane Vilaca, Margaret Paggiosi, Richard Eastell, Ralph Müller, Caitlyn J Collins
Type 1 diabetes mellitus (T1DM) has been linked to increased osteocyte apoptosis, local accumulation of mineralized lacunar spaces, and microdamage suggesting an impairment of the mechanoregulation network in affected individuals. Diabetic neuropathy might exacerbate this dysfunction through direct effects on bone turnover, and indirect effects on balance, muscle strength, and gait. However, the in vivo effects of impaired bone mechanoregulation on bone remodeling in humans remain underexplored. This longitudinal cohort study assessed consenting participants with T1DM and varying degree of distal symmetric sensorimotor polyneuropathy (T1DM, n = 20, median age 46...
January 4, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477665/metabolic-associated-fatty-liver-disease-is-characterized-by-a-post-oral-glucose-load-hyperinsulinemia-in-individuals-with-mild-metabolic-alterations
#14
JOURNAL ARTICLE
Théo Gignac, Gabrielle Trépanier, Marion Pradeau, Arianne Morissette, Anne-Laure Agrinier, Eric Larose, Julie Marois, Geneviève Pilon, Claudia Gagnon, Marie-Claude Vohl, André Marette, Anne-Marie Carreau
Metabolic-associated fatty liver disease (MAFLD) has been identified as risk factor of incident type 2 diabetes (T2D), but the underlying postprandial mechanisms remains unclear. We compared the glucose metabolism, insulin resistance, insulin secretion and insulin clearance post-oral glucose tolerance test (OGTT) between individuals with and without MAFLD. We included 50 individuals with a BMI between 25-40 kg/m2 and ≥1 metabolic alteration: increased fasting triglycerides or insulin, plasma glucose 5...
March 13, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38476561/hematological-indices-in-covid-19-patients-with-rhinosinusitis-mucormycosis
#15
JOURNAL ARTICLE
Seyedeh Sabereh Mojtahedi, Hossein Zarrinfar, Mehdi Bakhshaee
INTRODUCTION: Rhinosinusitis mucormycosis (RM) is an invasive opportunistic fungal infection, especially among COVID-19 patients. The current study aimed to assess the peripheral blood hematological disorders of COVID-19 patients-associated RM. MATERIALS AND METHODS: During ten month, in two COVID-19 centers in Mashhad, Iran, from June 2021 to March 2022, eighty-three patients suspected of COVID-19 with rhinosinusitis or rhino-orbital mucormycosis participated in this study...
March 2024: Iranian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38473085/animal-welfare-assessment-and-meat-quality-through-assessment-of-stress-biomarkers-in-fattening-pigs-with-and-without-visible-damage-during-slaughter
#16
JOURNAL ARTICLE
Natália Nami Ogawa, Giovanna Lima Silva, Ana Paula Ayub da Costa Barbon, Karina Keller Marques da Costa Flaiban, Caio Abercio da Silva, Luiene Moura Rocha, Ana Maria Bridi
The study aimed to investigate the physiological and meat quality differences between Non-Ambulatory, Non-Injured (NANI), and without apparent abnormalities (non-NANI) pigs in a commercial slaughterhouse setting, focusing on the impact of stress and health conditions on the overall well-being and meat quality of the animals. A total of 241 surgically castrated crossbred male pigs from Southern Brazil were analyzed, with 131 non-NANI pigs and 110 NANI pigs. Infrared orbital temperature, rectal temperature, hematological parameters, and meat quality measurements were collected...
February 23, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38469863/comparison-of-the-muscle-oxygenation-during-submaximal-and-maximal-exercise-tests-in-patients-post-coronavirus-disease-2019-syndrome-with-pulmonary-involvement
#17
JOURNAL ARTICLE
Başak Kavalcı Kol, Meral Boşnak Güçlü, Ece Baytok, Nilgün Yılmaz Demirci
INTRODUCTION: Pulmonary involvement is prevalent in patients with coronavirus disease 2019 (COVID-19). Arterial hypoxemia may reduce oxygen transferred to the skeletal muscles, possibly leading to impaired exercise capacity. Oxygen uptake may vary depending on the increased oxygen demand of the muscles during submaximal and maximal exercise. OBJECTIVE: This study aimed to compare muscle oxygenation during submaximal and maximal exercise tests in patients with post-COVID-19 syndrome with pulmonary involvement...
March 12, 2024: Physiotherapy Theory and Practice
https://read.qxmd.com/read/38469786/commutability-and-uncertainty-of-blood-hemoglobin-a1c-testing-materials
#18
JOURNAL ARTICLE
Wanutchaya Duanginta, Napaporn Apiratmateekul, Nam K Tran, Jintana Nammoonnoy, Wanvisa Treebuphachatsakul
BACKGROUND: Hemoglobin A1C (HbA1C) is used to evaluate glycemic control over a three-month period. Blood matrix-based HbA1C materials are needed for quality control and evaluation of HbA1C measurements. This study investigated the commutability of blood materials (BMs) and aimed to upgrade BMs for HbA1C testing for use as proficiency test (PT) material. METHODS: We measured BMs from a DM blood donor (n = 1), an in vitro glycation procedure (n = 3), and from commercial sources (n = 2) for HbA1C in parallel with fresh unprocessed BMs (n = 3) and clinical blood samples (n = 25)...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38469764/first-family-case-of-hemoglobinopathy-titusville-in-china-with-falsely-low-spo2-and-unmeasurable-sao2
#19
Yu-Xin Chen, Jia-Jing He, Yi-Yang Yu, Wei Dai, Ge Zhang
BACKGROUND: Normal hemoglobin is a tetrameric structure, consisting of two alpha-globin chains and two nonalpha (beta, gamma, delta) chains. Hemoglobinopathies occur when the presence of gene mutations affect the molecular structure or expression of the globin chains. METHODS: We reported the case of a 9-year-old Chinese girl who presented with abnormal low oxygen saturation values on pulse oximetry and no oximetry results were obtained during blood gas analysis (BGA)...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38468199/impact-of-itpa-gene-polymorphism-for-predicting-anemia-and-treatment-outcome-in-hcv-infected-patients-taking-sofosbuvir-ribavirin-therapy
#20
JOURNAL ARTICLE
Sameen Amjed, Hafiz Ghulam Murtaza Saleem, Sajjad Ullah, Shahzad Latif, Shabana, Junaid Jafar, Ahmad Bilal Waqar
BACKGROUND: Globally, 80 million people are suffering from chronic Hepatitis C virus (HCV) infection. Sofosbuvir ribavirin-based anti-HCV therapy is associated with anemia and other adverse effects. Polymorphisms of Inosine triphosphatase (ITPA) gene may cause functional impairment in the Inosine triphosphate pyrophosphatase enzyme, resulting in enhanced sustained viral response (SVR) and protection from ribavirin-associated anemia in patients on therapy. The study objective was to investigate the effect of Inosine triphosphatase gene polymorphism on SVR achievement, hemoglobin decline and ribavirin dose reduction in patients on therapy...
March 11, 2024: BMC Infectious Diseases
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