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https://www.readbyqxmd.com/read/27926922/high-speed-mouse-backcrossing-through-the-female-germ-line
#1
Erin Grove, Sigrid Eckardt, K John McLaughlin
Transferring mouse mutations into specific mouse strain backgrounds can be critical for appropriate analysis of phenotypic effects of targeted genomic alterations and quantitative trait loci. Speed congenic breeding strategies incorporating marker-assisted selection of progeny with the highest percentage target background as breeders for the next generation can produce congenic strains within approximately 5 generations. When mating selected donor males to target strain females, this may require more than 1 year, with each generation lasting 10 to 11 weeks including 3 weeks of gestation and 7 to 8 weeks until the males reach sexual maturity...
2016: PloS One
https://www.readbyqxmd.com/read/27926907/mammalian-meiotic-recombination-a-toolbox-for-genome-evolution
#2
Laia Capilla, Montserrat Garcia Caldés, Aurora Ruiz-Herrera
Meiotic recombination is a process that increases genetic diversity and is fundamental for sexual reproduction. Determining by which mechanisms genetic variation is generated and maintained across different phylogenetic groups provides the basis for our understanding of biodiversity and evolution. In this review, we go through different aspects of this essential phenomenon, paying special attention to mammals. We provide a comprehensive view on the organization of meiotic chromosomes and the mechanisms involved in the formation and genomic distribution of recombination hotspots, focusing on the factors influencing the formation and repair of the massive amount of self-induced DNA breaks in early stages of meiosis...
December 8, 2016: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/27926667/sexual-behaviors-and-hiv-status-a-population-based-study-among-older-adults-in-rural-south-africa
#3
Molly S Rosenberg, Francesc X Gómez-Olivé, Julia K Rohr, Brian C Houle, Chodziwadziwa W Kabudula, Ryan G Wagner, Joshua A Salomon, Kathleen Kahn, Lisa F Berkman, Stephen M Tollman, Till Bärnighausen
OBJECTIVE: To identify the unmet needs for HIV prevention among older adults in rural South Africa. METHODS: We analyzed data from a population-based sample of 5059 men and women aged 40 years and older from the study Health and Aging in Africa: Longitudinal Studies of INDEPTH Communities (HAALSI), which was carried out in the Agincourt health and sociodemographic surveillance system in the Mpumalanga province of South Africa. We estimated the prevalence of HIV (laboratory-confirmed and self-reported) and key sexual behaviors by age and sex...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27926644/cervical-cancer-screening-guideline-adherence-before-and-after-guideline-changes-in-pennsylvania-medicaid
#4
Natasha Parekh, Julie M Donohue, Aiju Men, Jennifer Corbelli, Marian Jarlenski
OBJECTIVE: To assess changes in cervical cancer screening after the 2009 American College of Obstetricians and Gynecologists' guideline change and to determine predictors associated with underscreening and overscreening among Medicaid-enrolled women. METHODS: We performed an observational cohort study of Pennsylvania Medicaid claims from 2007 to 2013. We evaluated guideline adherence of 18- to 64-year-old continuously enrolled women before and after the 2009 guideline change...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27925867/psychosocial-stressors-and-alcohol-use-severity-and-treatment-receipt-across-hiv-status-in-a-nationally-representative-sample-of-u-s-residents
#5
Emily C Williams, Young Sun Joo, Lauren Lipira, Joseph E Glass
BACKGROUND: Human Immunodeficiency Virus (HIV) is stigmatized and disproportionately impacts vulnerable populations. Thus people living with HIV (PLWH) may have greater exposure to psychosocial stressors than those without HIV. Exposure to psychosocial stressors may increase alcohol use and serve as barriers to alcohol treatment receipt. We evaluate whether psychosocial stressors, and alcohol use, symptom severity, and treatment receipt vary across HIV status in a general population sample of U...
December 7, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27925844/a-two-dose-heterologous-prime-boost-vaccine-regimen-eliciting-sustained-immune-responses-to-ebola-zaire-could-support-a-preventive-strategy-for-future-outbreaks
#6
Georgi Shukarev, Benoit Callendret, Kerstin Luhn, Macaya Douoguih, The Ebovac Consortium
The consequences of the 2013-16 Ebola Zaire virus disease epidemic in West Africa were grave. The economies, healthcare systems and communities of Guinea, Sierra Leone and Liberia were devastated by over 18 months of active Ebola virus transmission, followed by sporadic resurgences potentially related to sexual transmission by survivors with viral persistence in body fluids following recovery. The need to develop and implement strategies to prevent and mitigate future outbreaks is now beyond dispute. The potential for unpredictable outbreaks of indeterminate duration, and control challenges posed by the possibility of sporadic re-emergence, mean that implementation of an effective vaccination programme for outbreak containment necessitates a vaccine providing durable immunity...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925771/heterosexual-homosexual-and-bisexual-men-s-pupillary-responses-to-persons-at-different-stages-of-sexual-development
#7
Janice Attard-Johnson, Markus Bindemann, Caoilte Ó Ciardha
This study investigated whether pupil size during the viewing of images of adults and children reflects the sexual orientation of heterosexual, homosexual, and bisexual men (n = 100, Mage = 22). More specifically, we explored whether this measure corresponds with sexual age preferences for adults over children in nonpedophilic men. In general, results across three experiments, in which observers freely viewed or rated the sexual appeal of person images, suggest that pupil dilation to sexual stimuli is an indicator of sexual orientation toward adults...
December 7, 2016: Journal of Sex Research
https://www.readbyqxmd.com/read/27925486/real-talk-developing-a-computer-delivered-sexual-health-program-for-black-men-who-have-sex-with-men
#8
Charles Klein, Carmela Lomonaco
HIV disproportionately affects Black men who have sex with men (MSM), yet there are few evidence-based programs that respond to the diverse realities of Black MSM communities. This article examines the development of Real Talk, a new harm reduction-based, sexual health intervention for Black MSM. We first analyze the key themes from our formative research: (1) stigma, discrimination, and intersectionalities in the lives of Black MSM, (2) the importance of safe spaces and community provided by health promotion programs, and (3) moving beyond condoms in sexual health messaging...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27925485/translation-and-validation-of-a-condom-self-efficacy-scale-cses-chinese-version
#9
Yanping Zhao, Carlos King Ho Wong, Heidi Yin Hai Miu, Winnie Wing Yan Yuen, Weng Yee Chin, Tongyong Luo, William Chi Wai Wong
The English version of the Condom Self-Efficacy Scale (CSES) was translated, back-translated, and tested among a representative sample of the Hong Kong general population. It then underwent reconsolidation, confirmation, and validation following standard procedures. Construct validity was performed by exploratory factor analysis and item-scale correlation. Independent t-test and effect size were used to identify the score differences between consistent and non-consistent condom users. The factor loading scores of 14 items ranged between 0...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27925168/the-contrasting-role-of-male-relatedness-in-different-mechanisms-of-sexual-selection-in-red-junglefowl
#10
Cedric Tan Kai Wei, Philippa Doyle, Emma Bagshaw, David S Richardson, Stuart Wigby, Tommaso Pizzari
In structured populations, competition for reproductive opportunities should be relaxed among related males. The few tests of this prediction often neglect the fact that sexual selection acts through multiple mechanisms, both before and after mating. We performed experiments to study the role of within-group male relatedness across pre- and postcopulatory mechanisms of sexual selection in social groups of red junglefowl, Gallus gallus, in which two related males and one unrelated male competed over females unrelated to all the males...
December 7, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27925135/-protocols-in-healthcare-for-female-victims-of-sexual-violence-from-the-standpoint-of-healthcare-professionals
#11
Luiza Jane Eyre de Souza Vieira, Ana Cristina Feijó da Silva, Gracyelle Alves Remigio Moreira, Ludmila Fontenele Cavalcanti, Raimunda Magalhães da Silva
The use of protocols in health care for women suffering from sexual violence was analyzed from the standpoint of health professionals. It involved a qualitative study conducted in 18 institutions with 140 professionals interviewed in Fortaleza and Rio de Janeiro. After organization of the data, the clusters of meaning pointed to the potential benefits of the use of protocols; limits to be faced in the adoption of protocols; and the need for protocol development and professional training. The results revealed points of convergence and divergence between the two municipalities regarding the use of protocols in health care for women suffering from sexual violence...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925122/-abortion-and-stigma-an-analysis-of-the-scientific-literature-on-the-theme
#12
Leila Adesse, Claudia Bonan Jannotti, Katia Silveira da Silva, Vania Matos Fonseca
This article analyzes the scientific output on abortion and social stigma and the potential of the stigma category for abortion care in Brazil. An integrative review of publications on scientific databases without a time limit was conducted. Sixty-five publications with the social representations of women who had an abortion and the professionals who attended them were analyzed. The obstacles to the implementation of abortion laws and the protocols and norms that facilitate access to quality services care was explored...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925110/car-and-motorcycle-deaths-an-evolutionary-perspective
#13
André Luís Dos Santos Medeiros, Paulo Nadanovsky
Our aim was to assess differences between men and women in the likelihood of exposure to traffic as drivers of cars and motorcycles, and in the risk of dying from a car or a motorcycle crash, in order to verify the extent to which Darwin's Sexual Selection Theory could have predicted the findings and can help to interpret them. Study population was composed of men and women aged 18 to 60 years residents in the state of Rio de Janeiro between 2004 and 2010, and in the state of Rio Grande do Sul between 2001 and 2010...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925101/politicy-of-care-in-the-criticism-towards-gender-stereotypes
#14
Maria Raquel Gomes Maia Pires, Rosa Maria Godoy Serpa da Fonseca, Beatriz Padilla
Objectives: analyze gender inequalities among Brazilian women in Portugal and in contemporary nursing based on care politicity in the light of gender; disclose oppression of the female produced by the stereotypes that look upon women as natural caregivers; point out politicity to deconstruct gender stereotypes. Method: theoretical reflection with narrative review of literature to analyze classic references in the feminist epistemology combined with the care politicity thesis...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27925094/technology-for-self-care-for-ostomized-women-s-sexual-and-reproductive-health
#15
Andressa Ferreira Leite Ladislau Albuquerque, Ana Karina Bezerra Pinheiro, Francisca Márcia Pereira Linhares, Tatiane Gomes Guedes
Objective: to validate the technology of printed booklets on self-care for ostomized women's sexual and reproductive health. Method: a methodological study was performed with a focus on the construction and validity of a printed booklet. The content of this booklet was validated by 11 specialist judges/nurses, according to a Content Validity Index (CVI) equal to or higher than 0.80. Appearance was validated by nine ostomized women, according to an assessment of the difficulty and convenience of the educational material...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27925091/aids-in-the-elderly-reasons-that-lead-to-late-diagnosis
#16
Rúbia Aguiar Alencar, Suely Itsuko Ciosak
Objective: to investigate elderly living with HIV/Aids and health professionals, what are the reasons that lead to late diagnosis of HIV infection in the elderly. Method: prospective, qualitative study, conducted at a specialized outpatient clinic with elderly living with HIV/Aids, diagnosed age over 60 years and in the Family Health Strategy units with nurses and physicians. Data were collected through interviews and verified by content analysis, using the theoretical framework of vulnerability...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27924710/occupational-risk-factors-for-prostate-cancer-in-an-area-of-former-coal-iron-and-steel-industries-in-germany-part-1-results-from-a-study-performed-in-the-1980s
#17
Silvia Dickhut, Wolfgang Urfer, Susanne Reich, Tiemo Bandel, Karl-Dieter Bremicker, Wolfgang Neugebauer, Jürgen Sökeland, Hermann M Bolt, Klaus Golka
Prostate cancer is the most frequent occurring malignancy in men in many Western countries. Unfortunately, only a few studies on occupational risk factors have been published. Thus, the aim of this study was to investigate possible occupational risk factors in a former center of coal, iron, and steel industries the greater Dortmund area, located in the western part of Germany. In three local departments of urology, a total of 238 prostate cancer cases and 414 patients with benign prostatic hyperplasia as controls were requested to provide information for all jobs ever performed for 6 mo or longer...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27924667/contraceptive-practices-in-women-with-sickle-cell-disease
#18
Natália S Carvalho, Josefina Pellegrini Braga, Márcia Barbieri, Maria R Torloni, Maria S Figueiredo, Cristina A F Guazzelli
This was a cross-sectional study of sexually active women with sickle-cell disease (SCD) managed at São Paulo Federal University during a one-year period. A total of 54 women were included. Mean age was 32.0 (11.2, standard deviation) years and almost 95% were black or of mixed racial ancestry. Almost 80% reported a history of multiple blood transfusions, 50% had kidney disease and 17% had a history of thrombosis. Over 80% of them had used some form of contraception, mostly combined hormonal contraceptive (52%) or progestin-only contraceptives (46%)...
December 7, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27924621/change-in-risk-perceptions-and-marijuana-and-cigarette-use-among-african-american-young-adult-females-in-an-hiv-prevention-intervention
#19
Sarah J Javier, Jasmine A Abrams, Melanie P Moore, Faye Z Belgrave
Cigarette smoking and marijuana use have been tied to increased risky sexual behaviors, which may exacerbate risk of HIV transmission and other STIs (sexually transmitted infections). Research suggests that change in general perceptions of risk is associated with change in non-domain-targeted behaviors. The goal of the current study was to determine whether change in general risk perceptions among African American college females enrolled in a culturally-tailored HIV prevention intervention would be associated with decreased cigarette and marijuana use over time...
December 6, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27924513/reproductive-health-service-utilization-and-social-determinants-among-married-female-rural-to-urban-migrants-in-two-metropolises-china
#20
Zhi-Yong Liu, Jiang Li, Yang Hong, Lan Yao
Reproductive health (RH) education and services of female migrants in China have become an important health issue. This research aimed to investigate the RH knowledge and utilization among married female migrants, and to explore the influencing factors from the perspectives of population and sociology. We conducted a cross-section survey in Shenzhen and Wuhan, China, using the purposive sampling method. A total of 1021 rural-to-urban married migrants were recruited, with 997 valid survey results obtained. A face-to-face structured questionnaire survey was used, with primary focus on knowledge of fertility, contraception, family planning policy and sexual transmitted diseases/acquired immunodeficiency syndrome (STD/AIDs), and RH service utilization...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
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