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https://www.readbyqxmd.com/read/28811072/evolution-of-hemoglobin-loci-and-their-regulatory-elements
#1
REVIEW
Sjaak Philipsen, Ross C Hardison
Across the expanse of vertebrate evolution, each species produces multiple forms of hemoglobin in erythroid cells at appropriate times and in the proper amounts. The multiple hemoglobins are encoded in two globin gene clusters in almost all species. One globin gene cluster, linked to the gene NPRL3, is preserved in all vertebrates, including a gene cluster encoding the highly divergent globins from jawless vertebrates. This preservation of synteny may reflect the presence of a powerful enhancer of globin gene expression in the NPRL3 gene...
August 9, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28810024/effect-of-an-intensive-lifestyle-intervention-on-glycemic-control-in-patients-with-type-2-diabetes-a-randomized-clinical-trial
#2
Mette Yun Johansen, Christopher Scott MacDonald, Katrine Bagge Hansen, Kristian Karstoft, Robin Christensen, Maria Pedersen, Louise Seier Hansen, Morten Zacho, Anne-Sophie Wedell-Neergaard, Signe Tellerup Nielsen, Ulrik Wining Iepsen, Henning Langberg, Allan Arthur Vaag, Bente Klarlund Pedersen, Mathias Ried-Larsen
Importance: It is unclear whether a lifestyle intervention can maintain glycemic control in patients with type 2 diabetes. Objective: To test whether an intensive lifestyle intervention results in equivalent glycemic control compared with standard care and, secondarily, leads to a reduction in glucose-lowering medication in participants with type 2 diabetes. Design, Setting, and Participants: Randomized, assessor-blinded, single-center study within Region Zealand and the Capital Region of Denmark (April 2015-August 2016)...
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28807357/development-and-initial-validation-of-the-macrophage-activation-syndrome-primary-hemophagocytic-lymphohistiocytosis-score-a-diagnostic-tool-that-differentiates-primary-hemophagocytic-lymphohistiocytosis-from-macrophage-activation-syndrome
#3
Francesca Minoia, Francesca Bovis, Sergio Davì, Antonella Insalaco, Kai Lehmberg, Susan Shenoi, Sheila Weitzman, Graciela Espada, Yi-Jin Gao, Jordi Anton, Toshiyuki Kitoh, Ozgur Kasapcopur, Helga Sanner, Rosa Merino, Itziar Astigarraga, Maria Alessio, Michael Jeng, Vyacheslav Chasnyk, Kim E Nichols, Zeng Huasong, Caifeng Li, Concetta Micalizzi, Nicolino Ruperto, Alberto Martini, Randy Q Cron, Angelo Ravelli, AnnaCarin Horne
OBJECTIVE: To develop and validate a diagnostic score that assists in discriminating primary hemophagocytic lymphohistiocytosis (pHLH) from macrophage activation syndrome (MAS) related to systemic juvenile idiopathic arthritis. STUDY DESIGN: The clinical, laboratory, and histopathologic features of 362 patients with MAS and 258 patients with pHLH were collected in a multinational collaborative study. Eighty percent of the population was assessed to develop the score and the remaining 20% constituted the validation sample...
August 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28796597/a-home-based-type-2-diabetes-self-management-intervention-in-rural-guatemala
#4
David Flood, Jessica Hawkins, Peter Rohloff
INTRODUCTION: Diabetes self-management education (DSME) is a fundamental element of type 2 diabetes care. Although 75% of adults with diabetes worldwide live in low-income and middle-income countries (LMICs), limited DSME research has been conducted in LMICs. The objective of this study was to evaluate a home-based DSME intervention in rural Guatemala. METHODS: We conducted a prospective study of a DSME intervention using a quasi-experimental, single-group pretest-posttest design...
August 10, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28793787/the-roles-of-nrf2-in-modulating-cellular-iron-homeostasis
#5
Michael John Kerins, Aikseng Ooi
SIGNIFICANCE: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite oxidation. However, excess labile iron facilitates the formation of oxygen-derived free radicals capable of damaging biomolecules. Therefore, biological utilization of iron is a tightly regulated process. The nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor, which can respond to oxidative and electrophilic stress, regulates several genes involved in iron metabolism...
August 10, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28793329/using-the-mwc-model-to-describe-heterotropic-interactions-in-hemoglobin
#6
Olga Rapp, Ofer Yifrach
Hemoglobin is a classical model allosteric protein. Research on hemoglobin parallels the development of key cooperativity and allostery concepts, such as the 'all-or-none' Hill formalism, the stepwise Adair binding formulation and the concerted Monod-Wymann-Changuex (MWC) allosteric model. While it is clear that the MWC model adequately describes the cooperative binding of oxygen to hemoglobin, rationalizing the effects of H+, CO2 or organophosphate ligands on hemoglobin-oxygen saturation using the same model remains controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28791737/bone-marrow-fat-changes-after-gastric-bypass-surgery-are-associated-with-loss-of-bone-mass
#7
Tiffany Y Kim, Ann V Schwartz, Xiaojuan Li, Kaipin Xu, Dennis M Black, Dimitry M Petrenko, Lygia Stewart, Stanley J Rogers, Andrew M Posselt, Jonathan T Carter, Dolores M Shoback, Anne L Schafer
Bone marrow fat is a unique fat depot that may regulate bone metabolism. Marrow fat is increased in states of low bone mass, severe underweight, and diabetes. However, longitudinal effects of weight loss and improved glucose homeostasis on marrow fat are unclear, as is the relationship between marrow fat and bone mineral density (BMD) changes. We hypothesized that after Roux-en-Y gastric bypass (RYGB) surgery, marrow fat changes are associated with BMD loss. We enrolled 30 obese women, stratified by diabetes status...
August 9, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28790874/lack-of-change-in-glucose-metabolism-in-eszopiclone-treated-primary-insomnia-patients
#8
Orfeu M Buxton, Milena K Pavlova, Shawn P O'Connor, Wei Wang, John W Winkelman
STUDY OBJECTIVES: Primary insomnia (PI) may increase diabetes risk. We tested the hypothesis that the effects of PI on glucose metabolism could be improved by 2 months of pharmacological treatment. METHODS: Adult men and women meeting clinical criteria for PI were studied (n=20, body mass index 25.1±2.7 kg/m(2), age 39.7±7.9) in a randomized, double-blind, placebo-controlled clinical trial. The study consisted of two 1-day inpatient admissions to a General Clinical Research Center separated by 2 months of at-home treatment with 3 mg eszopiclone or placebo...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28790836/evaluation-of-coronary-calcium-score-in-patients-with-normocalcemic-primary-hyperparathyroidism
#9
Patrícia Nunes Mesquita, Ana Paula Dornelas Leão Leite, Stella das Chagas Crisóstomo, Enio Veras Filho, Lucas da Cunha Xavier, Francisco Bandeira
RATIONALE: Given that the diagnosis of primary hyperparathyroidism (PHPT) is given at an increasingly less-symptomatic phase, and the literature data on the cardiovascular risk of patients with normocalcemic primary hyperparathyroidism (NPHPT) are controversial, the coronary calcium score (CCS), which is correlated with coronary artery disease, may be useful for clarifying the association between cardiovascular risk and NPHPT. OBJECTIVE: This research aims to describe the CCS and the clinical and laboratory variables of patients with NPHPT compared with a control group and to verify the presence of an association between NPHPT and CCS...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28783892/effect-of-hyperbaric-oxygen-therapy-on-complete-blood-count
#10
Ali Erdal Gunes, Samil Aktas
Complete blood count (CBC) is a routine diagnostic procedure for patients and a part of routine health inspection for healthy individuals. The effect of hyperbaric oxygen (HBO₂) on CBC is not known. The objective of this study was to determine the effects of HBO₂ on blood parameters in CBC with long-term HBO₂ therapy. In this study, patients received HBO₂ at the department of Underwater and Hyperbaric Clinical Medicine. CBC results were obtained at specific time points during HBO₂ therapy. The study recruited a total of 140 patients who met the research inclusion criteria...
July 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28780460/nanoscale-trifunctional-bovine-hemoglobin-for-fabricating-molecularly-imprinted-polydopamine-via-pickering-emulsions-hydrogels-polymerization
#11
Yanhua Sun, Shian Zhong
In this work, a novel strategy was developed for the selective recognition of protein based on oil-in-water Pickering emulsions-hydrogels polymerization and interfacial imprinting method. For the first time, nanoscale trifunctional bovine hemoglobin (BHb) played three roles simultaneously during the process, including emulsifier, template protein and sacrificial material for further exposing recognition sites. Prior to acting as stabilizers, bovine hemoglobin colloidal particles (BCPs) were firstly prepared by acidification and heat denaturation...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28780367/differential-effects-of-blood-insulin-and-hba1c-on-cerebral-amyloid-burden-and-neurodegeneration-in-nondiabetic-cognitively-normal-older-adults
#12
Min Soo Byun, Hyun Jung Kim, Dahyun Yi, Hyo Jung Choi, Hyewon Baek, Jun Ho Lee, Young Min Choe, Bo Kyung Sohn, Jun-Young Lee, Younghwa Lee, Hyunwoong Ko, Yu Kyeong Kim, Yun-Sang Lee, Chul-Ho Sohn, Jong Inn Woo, Dong Young Lee
We tested the hypothesis that lower insulin or higher glycated hemoglobin (HbA1c) levels in blood are associated with increased cerebral beta amyloid (Aβ) deposition and neurodegeneration in nondiabetic cognitively normal (CN) older adults. A total of 205 nondiabetic CN older adults underwent comprehensive clinical assessment, [(11)C]Pittsburgh compound B (PiB)-positron emission tomography (PET), [(18)F]fluorodeoxyglucose-PET, magnetic resonance imaging, and blood sampling for fasting insulin and HbA1c measurement...
July 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28777351/current-status-of-hba1c-biosensors
#13
REVIEW
Hua Lin, Jun Yi
Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α-amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements...
August 4, 2017: Sensors
https://www.readbyqxmd.com/read/28771832/spectracam-%C3%A2-a-new-polarized-hyperspectral-imaging-system-for-repeatable-and-reproducible-in-vivo-skin-quantification-of-melanin-total-hemoglobin-and-oxygen-saturation
#14
A Nkengne, J Robic, P Seroul, S Gueheunneux, M Jomier, K Vie
BACKGROUND: An accurate way to determine skin pigmentation is to acquire the spectral reflectance of a skin sample and to quantify chromophores by reverse calculation from physical models of light propagation. Therefore, we tested a new hyperspectral imaging device and software suite, the SpectraCam(®) system, and evaluated its accuracy to quantify skin chromophores. METHODS: Validation of the SpectraCam(®) system was performed by, firstly, comparing the known and the acquired reflectance spectra of color phantoms...
August 2, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28768300/androgen-deprivation-therapy-and-the-risk-of-anemia-in-men-with-prostate-cancer
#15
Blánaid M Hicks, Adi J Klil-Drori, Hui Yin, Lysanne Campeau, Laurent Azoulay
BACKGROUND: The use of androgen deprivation therapy in prostate cancer may be associated with an increased risk of anemia, but the evidence remains limited. This study aimed to determine if androgen deprivation is associated with increased risk of anemia in patients newly diagnosed with prostate cancer. METHODS: This was a population-based cohort study using the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episode Statistics repository...
September 2017: Epidemiology
https://www.readbyqxmd.com/read/28765240/proposed-core-set-of-items-for-measuring-disease-activity-in-systemic-juvenile-idiopathic-arthritis
#16
Elizaveta Limenis, Brian M Feldman, Camille Achonu, Michelle Batthish, Bianca Lang, Marjorie Mclimont, Sylvia Ota, Athimalaipet Ramanan, Rosie Scuccimarri, Nancy L Young, Rayfel Schneider
OBJECTIVE: To date, there are no standardized disease activity tools for systemic juvenile idiopathic arthritis (sJIA). We developed a core set of disease activity measures for sJIA. METHODS: We conducted a validation study in patients with sJIA recruited from 3 Canadian institutions. Disease activity scores were based on questionnaires, clinical factors, and laboratory measures. The physician's global assessment was our criterion standard. We determined the strength of association of each item with the criterion standard...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28761648/education-immigration-and-income-as-risk-factors-for-hemoglobin-a1c-70-mmol-mol-when-diagnosed-with-type-2-diabetes-or-latent-autoimmune-diabetes-in-adult-a-population-based-cohort-study
#17
Mats Martinell, Ronnie Pingel, Johan Hallqvist, Mozhgan Dorkhan, Leif Groop, Anders Rosengren, Petter Storm, Jan Stålhammar
OBJECTIVES: The aim of this research is to study education, income and immigration as risk factors for high hemoglobin A1c (HbA1c >70 mmol/mol (8.6%)) when diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA). RESEARCH DESIGN AND METHODS: Patients were included from the All New Diabetics in Scania study (2008-2013). Level of education, disposable income and immigration year were retrieved from the longitudinal integrated database for labour market research (LISA) register compiled by Statistics Sweden...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761645/is-glycemia-control-in-canadians-with-diabetes-individualized-a-cross-sectional-observational-study
#18
Michael J Coons, Michelle Greiver, Babak Aliarzadeh, Christopher Meaney, Rahim Moineddin, Tyler Williamson, John Queenan, Catherine H Yu, David G White, Tara Kiran, Jennifer J Kane
OBJECTIVE: Diabetes guidelines recommend individualized glycemic targets: tighter control in younger, healthier patients and consideration of more moderate control in the elderly and those with coexisting illnesses. Our objective was to examine whether glycemic control varied by age and comorbidities in Canadian primary care. RESEARCH DESIGN AND METHODS: Cross-sectional study using data from the electronic medical records of 537 primary care providers across Canada; 30 416 patients with diabetes, aged 40 or above, with at least one encounter and one hemoglobin A1c (HbA1c) measurement between 1 January 2012 and 31 December 2013...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28757926/awareness-of-the-necessity-of-regular-eye-examinations-among-diabetics-the-yazd-eye-study
#19
Marzieh Katibeh, Hamid Ahmadieh, Ramin Beiranvand, Reza Soleimanizad, Mohammad Ali Javadi
BACKGROUND: Diabetic retinopathy and its consequence, diabetic macular edema, are leading causes of vision loss in diabetics and can develop even in the first years after onset of diabetes. Being asymptomatic in primary phase and having compensatory effect of bilateral vision delay the necessity of eye care utilization. We conducted this study to determine diabetic individuals' level of awareness about the importance of regular eye examinations. METHODS: As part of the cross-sectional, population-based, Yazd Eye Study on people aged 40-80 years, diabetic participants were identified for enrollment in this research...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28757462/innocuousness-of-a-polyherbal-formulation-a-case-study-using-a-traditional-thai-antihypertensive-herbal-recipe-in-rodents
#20
Tossaton Charoonratana, Jirapa Puntarat, Sujinthara Vinyoocharoenkul, Teeratad Sudsai, Kingkan Bunluepuech
Recently, a traditional Thai antihypertensive herbal recipe has reportedly been used in Thailand. Its ingredients have long featured in traditional Thai medicine preparations; however, research indicates that the presence of one of them - Tinospora crispa - may have negative effects on the liver and kidneys. Thus, the safety data of this recipe must be proved in animal models prior to conducting any studies in humans. The present case study aims to evaluate the safety of this recipe in Swiss albino mice and Wistar rats through acute and sub-chronic toxicity studies, respectively...
July 27, 2017: Food and Chemical Toxicology
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