keyword
MENU ▼
Read by QxMD icon Read
search

Blimp1

keyword
https://www.readbyqxmd.com/read/27924626/expression-of-the-activation-markers-blimp1-foxp1-and-pstat3-in-extranodal-diffuse-large-b-cell-lymphomas
#1
Georgios Petrakis, Ioannis Kostopoulos, Ioannis Venizelos, Maria Lambropoulou, Kyriakos Vouras, Sofia Vakalopoulou, Eudokia Mandala, Constantinos Tsatalas, Nicolas Papadopoulos
Different studies have suggested that the expression of biomarkers related to lymphoid cell activation may provide information on the behavior of DLBCL. Most studies have concentrated on nodal or a mixture of nodal and extranodal lymphomas. The differential expression and potential clinical impact of these markers in a homogeneous group of extranodal DLBCLs are not well defined. In this study, we investigated the expression of three activation markers, Blimp1, Foxp1 and pStat3, in a cohort of 35 extranodal DLBCLs homogeneously treated with R-CHOP...
December 7, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27746783/anti-lipid-igg-antibodies-are-produced-via-germinal-centers-in-a-murine-model-resembling-human-lupus
#2
Carlos Wong-Baeza, Albany Reséndiz-Mora, Luis Donis-Maturano, Isabel Wong-Baeza, Luz Zárate-Neira, Juan Carlos Yam-Puc, Juana Calderón-Amador, Yolanda Medina, Carlos Wong, Isabel Baeza, Leopoldo Flores-Romo
Anti-lipid IgG antibodies are produced in some mycobacterial infections and in certain autoimmune diseases [such as anti-phospholipid syndrome, systemic lupus erythematosus (SLE)]. However, few studies have addressed the B cell responses underlying the production of these immunoglobulins. Anti-lipid IgG antibodies are consistently found in a murine model resembling human lupus induced by chlorpromazine-stabilized non-bilayer phospholipid arrangements (NPA). NPA are transitory lipid associations found in the membranes of most cells; when NPA are stabilized they can become immunogenic and induce specific IgG antibodies, which appear to be involved in the development of the mouse model of lupus...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27734359/efficient-induction-and-isolation-of-human-primordial-germ-cell-like-cells-from-competent-human-pluripotent-stem-cells
#3
Naoko Irie, M Azim Surani
We recently reported a robust and defined culture system for the specification of human primordial germ cell-like cells (hPGCLCs) from human pluripotent stem cells (hPSCs), both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) in vitro (Irie et al. Cell 160: 253-268, 2015). Similar attempts previously produced hPGCLCs from hPSCs at a very low efficiency, and the resulting cells were not fully characterized. A key step, which facilitated efficient hPGCLC specification from hPSCs, was the induction of a "competent" state for PGC fate via the medium containing a cocktail of four inhibitors...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27720607/the-germ-cell-fate-of-cynomolgus-monkeys-is-specified-in-the-nascent-amnion
#4
Kotaro Sasaki, Tomonori Nakamura, Ikuhiro Okamoto, Yukihiro Yabuta, Chizuru Iwatani, Hideaki Tsuchiya, Yasunari Seita, Shinichiro Nakamura, Naoto Shiraki, Tetsuya Takakuwa, Takuya Yamamoto, Mitinori Saitou
The germ cell lineage ensures reproduction and heredity. The mechanism for germ cell specification in primates, including humans, has remained unknown. In primates, upon implantation the pluripotent epiblast segregates the amnion, an extra-embryonic membrane eventually ensheathing an embryo, and thereafter initiates gastrulation to generate three germ layers. Here, we show that in cynomolgus monkeys, the SOX17/TFAP2C/BLIMP1-positive primordial germ cells (cyPGCs) originate from the dorsal amnion at embryonic day 11 (E11) prior to gastrulation...
October 24, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27696611/prdm1-blimp1-is-widely-distributed-to-the-nascent-fetal-placental-interface-in-the-mouse-gastrula
#5
Maria M Mikedis, Karen M Downs
BACKGROUND: PRDM1 is a transcriptional repressor that contributes to primordial germ cell (PGC) development. During early gastrulation, epiblast-derived PRDM1 is thought to be restricted to a lineage-segregated germ line in the allantois. However, given recent findings that PGCs overlap an allantoic progenitor pool that contributes widely to the fetal-umbilical interface, posterior PRDM1 may also contribute to soma. RESULTS: Within the posterior mouse gastrula (early streak, 12-s stages, embryonic days ∼6...
October 3, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27505147/tumor-necrosis-factor-alpha-promotes-osteoclast-formation-via-pi3k-akt-pathway-mediated-blimp1-expression-upregulation
#6
LeCheng Wu, QunFeng Guo, Jun Yang, Bin Ni
Tumor necrosis factor alpha (TNF-α)-induced osteoclastogenesis has profound effects in states of inflammatory osteolysis such as rheumatoid arthritis, periprosthetic implant loosening, and periodontitis. However, the exact mechanisms by which TNF-α promotes RANKL-induced osteoclast formation remains poorly understood. B lymphocyte-induced maturation protein-1 (Blimp1) is a transcriptional repressor that plays crucial roles in the differentiation and/or function of various kinds of cells including osteoclasts...
August 9, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27487330/cxcr5-follicular-cytotoxic-t-cells-control-viral-infection-in-b-cell-follicles
#7
Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man, Claire Deleage, Martina Minnich, Benjamin J Meckiff, Yunbo Wei, Zhaohua Hou, Dimitra Zotos, Kevin A Fenix, Anurag Atnerkar, Simon Preston, Jeffrey G Chipman, Greg J Beilman, Cody C Allison, Lei Sun, Peng Wang, Jiawei Xu, Jesse G Toe, Hao K Lu, Yong Tao, Umaimainthan Palendira, Alexander L Dent, Alan L Landay, Marc Pellegrini, Iain Comerford, Shaun R McColl, Timothy W Schacker, Heather M Long, Jacob D Estes, Meinrad Busslinger, Gabrielle T Belz, Sharon R Lewin, Axel Kallies, Di Yu
During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differentiation of these cells, which we have called 'follicular cytotoxic T cells' (TFC cells), required the transcription factors Bcl6, E2A and TCF-1 but was inhibited by the transcriptional regulators Blimp1, Id2 and Id3...
October 2016: Nature Immunology
https://www.readbyqxmd.com/read/27478306/the-expression-of-t-cell-foxp3-and-t-bet-is-upregulated-in-severe-but-not-euthyroid-hashimoto-s-thyroiditis
#8
Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Sonja Jaman, Eva Novosadová, Jana Petrkova, Zdenka Navratilova, Mirjana Suver Stević, Martin Petrek
Hashimoto's thyroiditis (HT) is an organ-specific autoimmune disorder characterized by progressive thyroid failure. Th1 and Treg subset of CD4(+) cells have been implicated in the pathogenesis; however, less is known about their respective roles across the spectrum of HT clinical presentations. To shed more light on CD4(+) subsets role in HT, we investigated the mRNA expression levels of several Th1/Treg-associated transcription factors (T-bet/ETS1, HIF1α/BLIMP1/FOXP3) in peripheral blood T cells of 10 hypothyroid, untreated HT patients, 10 hypothyroid patients undergoing hormone replacement therapy, 12 euthyroid HT subjects, and 11 healthy controls by the qRT-PCR...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27436361/rock2-signaling-is-required-to-induce-a-subset-of-t-follicular-helper-cells-through-opposing-effects-on-stats-in-autoimmune-settings
#9
Jonathan M Weiss, Wei Chen, Melanie S Nyuydzefe, Alissa Trzeciak, Ryan Flynn, James R Tonra, Suzana Marusic, Bruce R Blazar, Samuel D Waksal, Alexandra Zanin-Zhorov
Rho-associated kinase 2 (ROCK2) determines the balance between human T helper 17 (TH17) cells and regulatory T (Treg) cells. We investigated its role in the generation of T follicular helper (TFH) cells, which help to generate antibody-producing B cells under normal and autoimmune conditions. Inhibiting ROCK2 in normal human T cells or peripheral blood mononuclear cells from patients with active systemic lupus erythematosus (SLE) decreased the number and function of TFH cells induced by activation ex vivo. Moreover, inhibition of ROCK2 activity decreased the abundance of the transcriptional regulator Bcl6 (B cell lymphoma 6) and increased that of Blimp1 by reducing the binding of signal transducer and activator of transcription 3 (STAT3) and increasing that of STAT5 to the promoters of the genes Bcl6 and PRDM1, respectively...
July 19, 2016: Science Signaling
https://www.readbyqxmd.com/read/27435916/myeloid-deletion-of-nemo-causes-osteopetrosis-in-mice-owing-to-upregulation-of-transcriptional-repressors
#10
Gaurav Swarnkar, Kyuhwan Shim, Amjad M Nasir, Kuljeet Seehra, Hung-Po Tim Chen, Gabriel Mbalaviele, Yousef Abu-Amer
The transcription factor NF-κB is central to numerous physiologic processes including bone development, and its activation is controlled by IKKγ (also called NEMO), the regulatory subunit of IKK complex. NEMO is X-linked, and mutations in this gene result in Incontinentia Pigmenti in human hemizygous females. In mice, global deficiency causes embryonic lethality. In addition, certain point mutations in the NEMO (IKBKG) human gene manifest skeletal defects implicating NEMO in the regulation of bone homeostasis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27404351/a-pluripotency-platform-for-prdm14
#11
Adam Burton, Maria-Elena Torres-Padilla
The tripartite network of Prdm14, Blimp1, and AP2γ is essential for the important process of germ cell specification, but their precise molecular mechanisms of action remain lacking. Tu and colleagues (2016) report in Nature that the transcriptional co-repressor CBFA2T2 is an essential interactor protein regulating PRDM14 function, shedding light into the mechanisms directing germline formation and pluripotency.
July 11, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27386862/post-transcriptional-regulation-of-klf4-by-high-risk-human-papillomaviruses-is-necessary-for-the-differentiation-dependent-viral-life-cycle
#12
Vignesh Kumar Gunasekharan, Yan Li, Jorge Andrade, Laimonis A Laimins
Human papillomaviruses (HPVs) are epithelial tropic viruses that link their productive life cycles to the differentiation of infected host keratinocytes. A subset of the over 200 HPV types, referred to as high-risk, are the causative agents of most anogenital malignancies. HPVs infect cells in the basal layer, but restrict viral genome amplification, late gene expression, and capsid assembly to highly differentiated cells that are active in the cell cycle. In this study, we demonstrate that HPV proteins regulate the expression and activities of a critical cellular transcription factor, KLF4, through post-transcriptional and post-translational mechanisms...
July 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27334271/blimp-1-blmp-1-and-metastasis-associated-protein-regulate-stress-resistant-development-in-caenorhabditis-elegans
#13
Moonjung Hyun, Jeongho Kim, Catherine Dumur, Frank C Schroeder, Young-Jai You
Environmental stress triggers multilevel adaptations in animal development that depend in part on epigenetic mechanisms. In response to harsh environmental conditions and pheromone signals, Caenorhabditis elegans larvae become the highly stress-resistant and long-lived dauer. Despite extensive studies of dauer formation pathways that integrate specific environmental cues and appear to depend on transcriptional reprogramming, the role of epigenetic regulation in dauer development has remained unclear. Here we report that BLMP-1, the BLIMP-1 ortholog, regulates dauer formation via epigenetic pathways; in the absence of TGF-β signaling (in daf-7 mutants), lack of blmp-1 caused lethality...
August 2016: Genetics
https://www.readbyqxmd.com/read/27300161/characterization-of-the-epigenetic-changes-during-human-gonadal-primordial-germ-cells-reprogramming
#14
C Eguizabal, L Herrera, L De Oñate, N Montserrat, P Hajkova, J C Izpisua Belmonte
Epigenetic reprogramming is a central process during mammalian germline development. Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the erasure of epigenetic memory, preventing the transmission of epimutations to the next generation. Apart from DNA demethylation, germline reprogramming has been shown to entail reprogramming of histone marks and chromatin remodelling. Contrary to other animal models, there is limited information about the epigenetic dynamics during early germ cell development in humans...
September 2016: Stem Cells
https://www.readbyqxmd.com/read/27261530/molecular-functions-of-the-transcription-factors-e2a-and-e2-2-in-controlling-germinal-center-b-cell-and-plasma-cell-development
#15
Miriam Wöhner, Hiromi Tagoh, Ivan Bilic, Markus Jaritz, Daniela Kostanova Poliakova, Maria Fischer, Meinrad Busslinger
E2A is an essential regulator of early B cell development. Here, we have demonstrated that E2A together with E2-2 controlled germinal center (GC) B cell and plasma cell development. As shown by the identification of regulated E2A,E2-2 target genes in activated B cells, these E-proteins directly activated genes with important functions in GC B cells and plasma cells by inducing and maintaining DNase I hypersensitive sites. Through binding to multiple enhancers in the Igh 3' regulatory region and Aicda locus, E-proteins regulated class switch recombination by inducing both Igh germline transcription and AID expression...
June 27, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27224915/foxp2-positive-diffuse-large-b-cell-lymphomas-exhibit-a-poor-response-to-r-chop-therapy-and-distinct-biological-signatures
#16
Kah Keng Wong, Duncan M Gascoyne, Elizabeth J Soilleux, Linden Lyne, Hayley Spearman, Giovanna Roncador, Lars M Pedersen, Michael B Møller, Tina M Green, Alison H Banham
FOXP2 shares partially overlapping normal tissue expression and functionality with FOXP1; an established diffuse large B-cell lymphoma (DLBCL) oncogene and marker of poor prognosis. FOXP2 is expressed in the plasma cell malignancy multiple myeloma but has not been studied in DLBCL, where a poor prognosis activated B-cell (ABC)-like subtype display partially blocked plasma cell differentiation. FOXP2 protein expression was detected in ABC-DLBCL cell lines, and in primary DLBCL samples tumoral FOXP2 protein expression was detected in both germinal center B-cell-like (GCB) and non-GCB DLBCL...
May 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27217539/dynamic-changes-in-id3-and-e-protein-activity-orchestrate-germinal-center-and-plasma-cell-development
#17
Renee Gloury, Dimitra Zotos, Malou Zuidscherwoude, Frederick Masson, Yang Liao, Jhaguaral Hasbold, Lynn M Corcoran, Phil D Hodgkin, Gabrielle T Belz, Wei Shi, Stephen L Nutt, David M Tarlinton, Axel Kallies
The generation of high-affinity antibodies requires germinal center (GC) development and differentiation of long-lived plasma cells in a multilayered process that is tightly controlled by the activity of multiple transcription factors. Here, we reveal a new layer of complexity by demonstrating that dynamic changes in Id3 and E-protein activity govern both GC and plasma cell differentiation. We show that down-regulation of Id3 in B cells is essential for releasing E2A and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation...
May 30, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27207558/adrenomedullin-2-improves-early-obesity-induced-adipose-insulin-resistance-by-inhibiting-the-class-ii-mhc-in-adipocytes
#18
Song-Yang Zhang, Ying Lv, Heng Zhang, Song Gao, Ting Wang, Juan Feng, Yuhui Wang, George Liu, Ming-Jiang Xu, Xian Wang, Changtao Jiang
MHC class II (MHCII) antigen presentation in adipocytes was reported to trigger early adipose inflammation and insulin resistance. However, the benefits of MHCII inhibition in adipocytes remain largely unknown. Here, we showed that human plasma polypeptide adrenomedullin 2 (ADM2) levels were negatively correlated with HOMA of insulin resistance in obese human. Adipose-specific human ADM2 transgenic (aADM2-tg) mice were generated. The aADM2-tg mice displayed improvements in high-fat diet-induced early adipose insulin resistance...
August 2016: Diabetes
https://www.readbyqxmd.com/read/27190036/the-transcriptional-repressor-blimp1-is-expressed-in-rare-luminal-progenitors-and-is-essential-for-mammary-gland-development
#19
Mohammed I Ahmed, Salah Elias, Arne W Mould, Elizabeth K Bikoff, Elizabeth J Robertson
Mammary gland morphogenesis depends on a tight balance between cell proliferation, differentiation and apoptosis, to create a defined functional hierarchy within the epithelia. The limited availability of stem cell/progenitor markers has made it challenging to decipher lineage relationships. Here, we identify a rare subset of luminal progenitors that express the zinc finger transcriptional repressor Blimp1, and demonstrate that this subset of highly clonogenic luminal progenitors is required for mammary gland development...
May 15, 2016: Development
https://www.readbyqxmd.com/read/27189179/sirt6-cooperates-with-blimp1-to-positively-regulate-osteoclast-differentiation
#20
So Jeong Park, Jeong-Eun Huh, Jihye Shin, Doo Ri Park, Ryeojin Ko, Gyu-Rin Jin, Dong-Hyun Seo, Han-Sung Kim, Hong-In Shin, Goo Taeg Oh, Hyun Seok Kim, Soo Young Lee
Global deletion of the gene encoding a nuclear histone deacetylase sirtuin 6 (Sirt6) in mice leads to osteopenia with a low bone turnover due to impaired bone formation. But whether Sirt6 regulates osteoclast differentiation is less clear. Here we show that Sirt6 functions as a transcriptional regulator to directly repress anti-osteoclastogenic gene expression. Targeted ablation of Sirt6 in hematopoietic cells including osteoclast precursors resulted in increased bone volume caused by a decreased number of osteoclasts...
2016: Scientific Reports
keyword
keyword
89654
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"