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https://www.readbyqxmd.com/read/28447848/spatial-biases-in-motion-extrapolation-for-manual-interception
#1
Sinéad A Reid, Joost C Dessing
The exact mechanisms by which humans control the manual interception of moving targets are currently unknown. Here, the authors explored the behaviors associated with the spatial control for manual interception. The examined task required controlling a cursor to intercept moving targets on a touch screen. They explored the effects of target motion direction, curvature and occlusion on manual interception. They observed occlusion-dependent spatial errors and arrival times for curved and diagonal trajectories (larger errors and earlier arrival of the finger at its final position with longer occlusion)...
April 27, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28447844/frontal-theta-band-oscillations-predict-error-correction-and-posterror-slowing-in-typing
#2
Çığır Kalfaoğlu, Tom Stafford, Elizabeth Milne
Performance errors are associated with robust behavioral and electroencephalography (EEG) effects. However, there is a debate about the nature of the relationship between these effects and implicit versus explicit error awareness. Our aim was to study the relationship between error related electrophysiological effects, such as spectral perturbations in fronto-medial theta band oscillations (FMT), and error awareness in typing. Typing has an advantage as an experimental paradigm in that detected errors are quickly and habitually signaled by the participant using backspace, allowing separation of detected from undetected errors without interruption in behavior...
April 27, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28445756/membrane-mechanics-of-primary-afferent-neurons-in-the-dorsal-root-ganglia-of-rats
#3
Hirosato Kanda, Jianguo G Gu
Membrane mechanics is an important biological factor regulating many cellular functions including cell motility, intercellular and intracellular signaling, gene expression, and membrane ion channel activity. Primary afferent neurons transduce sensory information about temperature, touch, and pain. These sensory functions may be profoundly affected by the states of primary afferent neuron mechanics. However, membrane mechanics of primary afferent neurons is largely unknown. In this study, we established the optical trapping technique for determining membrane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG)...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445542/no-touch-radiofrequency-ablation-using-multiple-electrodes-an-in-vivo-comparison-study-of-switching-monopolar-versus-switching-bipolar-modes-in-porcine-livers
#4
Won Chang, Jeong Min Lee, Jeong Hee Yoon, Dong Ho Lee, Sang Min Lee, Kyoung Bun Lee, Bo Ram Kim, Tae-Hyung Kim, Seunghyun Lee, Joon Koo Han
OBJECTIVE: To evaluate the in vivo technical feasibility, efficiency, and safety of switching bipolar (SB) and switching monopolar (SM) radiofrequency ablation (RFA) as a no-touch ablation technique in the porcine liver. MATERIALS AND METHODS: The animal care and use committee approved this animal study and 16 pigs were used in two independent experiments. In the first experiment, RFA was performed on 2-cm tumor mimickers in the liver using a no-touch technique in the SM mode (2 groups, SM1: 10 minutes, n = 10; SM2: 15 minutes, n = 10) and SB-mode (1 group, SB: 10 minutes, n = 10)...
2017: PloS One
https://www.readbyqxmd.com/read/28444624/targeting-ntrk-fusion-in-non-small-cell-lung-cancer-rationale-and-clinical-evidence
#5
REVIEW
Biagio Ricciuti, Marta Brambilla, Giulio Metro, Sara Baglivo, Roberta Matocci, Matteo Pirro, Rita Chiari
In the era of personalized medicine, the identification of targetable genetic alterations represented a major step forward in anticancer therapy. NTRK rearrangements represent the molecular driver of a subset of solid tumors, including 3% of non-small-cell lung cancers (NSCLCs). Preliminary data indicate that molecularly selected NSCLC patients harboring NTRK fusions derive an unprecedented clinical benefit from Trk-directed targeted therapies. The aim of this review is to describe the molecular biology of NTRK signaling pathway and to summarize the preclinical data on novel Trk inhibitors, touching upon the clinical development of these inhibitors for the treatment of advanced NSCLC, which have already shown encouraging anticancer activity and acceptable safety profile in early phase I clinical trials...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28443309/touch-preparation-for-the-rapid-diagnosis-of-disseminated-aspergillosis
#6
Hannah M Singer, Bobby Y Reddy, Marc E Grossman
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28442732/human-bipedal-instability-in-tree-canopy-environments-is-reduced-by-light-touch-fingertip-support
#7
L Johannsen, S R L Coward, G R Martin, A M Wing, A van Casteren, W I Sellers, A R Ennos, R H Crompton, S K S Thorpe
Whether tree canopy habitats played a sustained role in the ecology of ancestral bipedal hominins is unresolved. Some argue that arboreal bipedalism was prohibitively risky for hominins whose increasingly modern anatomy prevented them from gripping branches with their feet. Balancing on two legs is indeed challenging for humans under optimal conditions let alone in forest canopy, which is physically and visually highly dynamic. Here we quantify the impact of forest canopy characteristics on postural stability in humans...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442353/facebook-usage-on-smartphones-and-gray-matter-volume-of-the-nucleus-accumbens
#8
Christian Montag, Alexander Markowetz, Konrad Blaszkiewicz, Ionut Andone, Bernd Lachmann, Rayna Sariyska, Boris Trendafilov, Mark Eibes, Julia Kolb, Martin Reuter, Bernd Weber, Sebastian Markett
A recent study has implicated the nucleus accumbens of the ventral striatum in explaining why online-users spend time on the social network platform Facebook. Here, higher activity of the nucleus accumbens was associated with gaining reputation on social media. In the present study, we touched a related research field. We recorded the actual Facebook usage of N=62 participants on their smartphones over the course of five weeks and correlated summary measures of Facebook use with gray matter volume of the nucleus accumbens...
April 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28442340/empathy-during-consoling-touch-is-modulated-by-mu-rhythm-an-eeg-study
#9
L Peled-Avron, P Goldstein, S Yellinek, I Weissman-Fogel, S G Shamay-Tsoory
The aim of the present study was to examine the mechanisms of empathy for pain that contribute to consoling touch, a distress-alleviating contact behavior carried out by an observer in response to the suffering of a target. We tested romantic couples in a paradigm that involves consoling touch and examined the attenuation of the mu/alpha rhythm (8-13Hz) in the consoling partner. During the task, the toucher either held the consoled partner's right hand (human touch) or held onto the armrest of the chair (non-human touch), while the consoled partner experienced inflicted pain (pain condition) or did not experience any pain (no-pain condition)...
April 22, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28442332/the-individual-preferred-velocity-of-stroking-touch-as-a-stable-measurement
#10
Amanda Luong, Johanna Bendas, Roberta Etzi, Håkan Olausson, Ilona Croy
Affective touch is of fundamental importance in human social interactions and there is an increasing interest in using touch as a probe for general affective perception. To this end, we developed a test of preferred velocity (ToP-V) of touch and tested whether the individually preferred stroking velocity is a stable and valid measurement. In study one, thirty healthy participants (18-30years, 17 women) were examined with the ToP-V. Therefore, pairs of different slow stroking stimuli were presented by the Rotary Tactile Stimulator - a robotic device - on the forearm and the participants chose the velocity they preferred in a forced choice paradigm...
April 22, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28442273/the-role-of-bile-acids-in-nonalcoholic-fatty-liver-disease-and-nonalcoholic-steatohepatitis
#11
REVIEW
Monica D Chow, Yi-Horng Lee, Grace L Guo
Nonalcoholic fatty liver disease is growing in prevalence worldwide. It is started by the presence of macrosteatosis on liver histology but is often clinically asymptomatic. However, it can progress into nonalcoholic steatohepatitis which is a more severe form of liver disease characterized by inflammation and fibrosis. Further progression leads to cirrhosis, which predisposes patients to hepatocellular carcinoma or liver failure. The mechanism by which simple steatosis progresses to steatohepatitis is not entirely clear...
April 22, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28440817/effects-of-dopamine-d2-d3-receptor-antagonism-on-human-planning-and-spatial-working-memory
#12
M Naef, U Müller, A Linssen, L Clark, T W Robbins, C Eisenegger
Psychopharmacological studies in humans suggest important roles for dopamine (DA) D2 receptors in human executive functions, such as cognitive planning and spatial working memory (SWM). However, studies that investigate an impairment of such functions using the selective DA D2/3 receptor antagonist sulpiride have yielded inconsistent results, perhaps because relatively low doses were used. We believe we report for the first time, the effects of a higher (800 mg p.o.) single dose of sulpiride as well as of genetic variation in the DA receptor D2 gene (DA receptor D2 Taq1A polymorphism), on planning and working memory...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28439115/porous-materials-look-but-don-t-touch
#13
Ben Slater, Sanliang Ling
No abstract text is available yet for this article.
April 25, 2017: Nature Materials
https://www.readbyqxmd.com/read/28438414/predictors-of-trachomatous-trichiasis-surgery-outcome
#14
Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Bizuayehu Gashaw, Guadie S Wondimagegn, Hiwot D Mengistie, Saul N Rajak, Kelly Callahan, Helen A Weiss, Matthew J Burton
PURPOSE: Unfavorable outcomes after trachomatous trichiasis (TT) surgery are undermining the global trachoma elimination effort. This analysis investigates predictors of postoperative TT (PTT), eyelid contour abnormalities (ECAs), and granuloma in the 2 most common TT surgery procedures: posterior lamellar tarsal rotation (PLTR) and bilamellar tarsal rotation (BLTR). DESIGN: Secondary data analysis from a randomized, controlled, single-masked clinical trial. PARTICIPANTS: A total of 1000 patients with TT, with lashes touching the eye or evidence of epilation, in association with tarsal conjunctival scarring...
April 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28437271/surgical-management-of-traumatic-peripheral-osteoma-of-the-mandible
#15
André Bachega Gomes Geron, Vinícius Almeida Carvalho, Jessica Luana Dos Santos, Luciana Yamamoto Almeida, Jorge Esquiche León, Alexandre Elias Trivellato, Cássio Edvard Sverzut
Osteomas are benign osteogenic lesions that result from the proliferation of mature bone. Three variants are known: central, peripheral, and extraskeletal. The peripheral variant is the most common and it most frequently affects the paranasal sinuses, rarely occurring in the jaws. This article describes the case of a 33-year-old white male patient who was referred complaining of facial asymmetry. Clinical examination revealed an increase in volume at the base of the right side of the mandible, hard bony consistency and well delimited, painless to the touch, without signs of infection or intraoral alterations...
April 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28437257/creation-of-quasi-dirac-points-in-the-floquet-band-structure-of-bilayer-graphene
#16
W M Cheung, K S Chan
We study the Floquet quasi-energy band structure of bilayer graphene when it is illuminated by two laser lights with frequencies [Formula: see text] and [Formula: see text] using Floquet theory. We focus on the dynamical gap formed by the conduction band with Floquet index  =  -1 and the valence band with Floquet index  =  +1 to understand how Dirac points can be formed. It is found that the dynamical gap does not have rotation symmetry in the momentum space, and quasi-Dirac points, where the conduction and valence bands almost touch, can be created when the dynamical gap closes along some directions with suitably chosen radiation parameters...
April 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28437105/a-virtual-environment-for-studying-the-docking-interactions-of-rigid-biomolecules-with-haptics
#17
Georgios Iakovou, Steven Hayward, Stephen Laycock
Haptic technology facilitates user interaction with the virtual world via the sense of touch. In molecular docking, haptics enables the user to sense the interaction forces during the docking process. Here we describe a haptics-assisted interactive software tool, called Haptimol RD, for the study of docking interactions. By utilising GPU-accelerated proximity querying methods very large systems can now be studied. Methods for force scaling, multipoint collision response and haptic navigation are described that address force stability issues that are particular to the interactive docking of large systems...
April 24, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28437095/reliability-of-single-crystal-silver-nanowire-based-systems-stress-assisted-instabilities
#18
Rajaprakash Ramachandramoorthy, Yanming Wang, Amin Aghaei, Gunther Richter, Wei Cai, Horacio D Espinosa
Time-dependent mechanical characterization of nanowires is critical to understand their long-term reliability in applications such as flexible-electronics and touch screens. It is also of great importance to develop a theoretical framework for experimentation and analysis on the mechanics of nanowires under time-dependent loading conditions such as stress-relaxation and fatigue. Here, we combine in situ scanning electron microscope (SEM)/transmission electron microscope (TEM) tests with atomistic and phase-field simulations to understand the deformation mechanisms of single crystal silver nanowires held under constant strain...
April 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28436981/identification-of-spinal-circuits-involved-in-touch-evoked-dynamic-mechanical-pain
#19
Longzhen Cheng, Bo Duan, Tianwen Huang, Yan Zhang, Yangyang Chen, Olivier Britz, Lidia Garcia-Campmany, Xiangyu Ren, Linh Vong, Bradford B Lowell, Martyn Goulding, Yun Wang, Qiufu Ma
Mechanical hypersensitivity is a debilitating symptom for millions of chronic pain patients. It exists in distinct forms, including brush-evoked dynamic and filament-evoked punctate hypersensitivities. We reduced dynamic mechanical hypersensitivity induced by nerve injury or inflammation in mice by ablating a group of adult spinal neurons defined by developmental co-expression of VGLUT3 and Lbx1 (VT3(Lbx1) neurons): the mice lost brush-evoked nocifensive responses and conditional place aversion. Electrophysiological recordings show that VT3(Lbx1) neurons form morphine-resistant polysynaptic pathways relaying inputs from low-threshold Aβ mechanoreceptors to lamina I output neurons...
April 24, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28436592/diagnostic-value-of-virtual-touch-tissue-imaging-quantification-for-evaluating-median-nerve-stiffness-in-carpal-tunnel-syndrome
#20
Chen Zhang, Miao Li, Jue Jiang, Qi Zhou, Li Xiang, Yajuan Huang, Wenrui Ban, Wei Peng
OBJECTIVES: To measure the shear wave velocity (SWV) of the median nerve by Virtual Touch tissue imaging quantification (VTIQ; Siemens AG, Erlangen, Germany) through the beginning of the carpal tunnel and to determine whether VTIQ could be used to diagnose carpal tunnel syndrome. METHODS: This study recruited 49 consecutive patients (72 wrists) with a definitive diagnosis of carpal tunnel syndrome and 23 healthy volunteers (46 wrists). We measured the median nerve diameter and cross-sectional area by 2-dimensional sonography and the SWV by VTIQ...
April 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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