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Holy Grail

Hope Cottrill, Stephanie Cason, Scott Caroen, Bryan Oronsky, Elvis Donaldson
This case report describes the clinical course of a heavily pretreated patient enrolled on the Phase II QUADRUPLE THREAT clinical trial (NCT02489903) with recurrent metastatic epithelial ovarian cancer that was previously treated with a platinum doublet and that benefited from another reintroduction of a platinum doublet after a brief priming period with RRx-001. Platinum-taxane combination is the initial treatment of choice in ovarian cancer and the "go-to regimen" for patients with recurrent, platinum-sensitive disease...
January 2018: Journal of Investigative Medicine High Impact Case Reports
Jens-Uwe Voigt
No abstract text is available yet for this article.
March 9, 2018: JACC. Cardiovascular Imaging
Jared W Young, Zackary A Cope, Benedetto Romoli, Esther Schrurs, Aniek Joosen, Jordy van Enkhuizen, Richard F Sharp, Davide Dulcis
Developing novel therapeutics for bipolar disorder (BD) has been hampered by limited mechanistic knowledge how sufferers switch between mania and depression-how the same brain can switch between extreme states-described as the "holy grail" of BD research. Strong evidence implicates seasonally-induced switching between states, with mania associated with summer-onset, depression with winter-onset. Determining mechanisms of and sensitivity to such switching is required. C57BL/6J and dopamine transporter hypomorphic (DAT-HY 50% expression) mice performed a battery of psychiatry-relevant behavioral tasks following 2-week housing in chambers under seasonally relevant photoperiod extremes...
February 27, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Ashwinikumar A Raut, Ashok D B Vaidya
For millennia, cow has been central to Indian economy, life and culture. There are innumerable references-Vedic and subsequent to the sacred significance of cow. The benefits of cow have been described at length in relation to agriculture, environment, health, economy and spiritual progress. However, the socio-political issues surrounding cow as a sacred animal have raised acrimonious debates. In Ayurveda also, there is a long tradition of using cow products for positive health, pharmaceutical processes and in therapeutics...
February 24, 2018: Journal of Ayurveda and Integrative Medicine
David Hardy, Elodie Desuzinges Mandon, Alice Rothnie, Anass Jawhari
Membrane proteins (MP) are stable in their native lipid environment. To enable structural and functional investigations, MP need to be extracted from the membrane. This is a critical step that represents the main obstacle for MP biochemistry and structural biology. General guidelines and rules for membrane protein solubilization remain difficult to establish. This review aims to provide the reader with a comprehensive overview of the general concepts of MP solubilization and stabilization as well as recent advances in detergents innovation...
February 22, 2018: Methods: a Companion to Methods in Enzymology
Govinder S Pawar, Asif A Tahir
Photoelectrochemical (PEC) water splitting to produce solar fuel (hydrogen) has long been considered as the Holy Grail to a carbon-free hydrogen economy. The PEC concept to produce solar fuel is to emulate the natural photosynthesis using man made materials. The bottle-neck in realising the concept practically has been the difficulty in identifying stable low-cost semiconductors that meet the thermodynamic and kinetic criteria for photoelectrolysis. We have fabricated a novel p-type LaFeO3 photoelectrode using an inexpensive and scalable spray pyrolysis method...
February 22, 2018: Scientific Reports
Xiaoyu Guo, Wenjing Zhao, Zuojia Liu, Jin Wang
Ras-targeted therapy represents a 'holy grail' in oncology. Based on our model prediction, Spiclomazine freezing the intermediate conformation of activated Ras is central to cancer therapeutics. We show here that Spiclomazine leads to an effective suppression in Ras-mediated signaling through abrogating the KRas-GTP level in the KRas -driven pancreatic cancer. The Ras-mediated signaling inhibition leads to dramatically reduced survivals of five KRas -driven pancreatic cancer cell lines with IC50 ranging 19...
January 23, 2018: Oncotarget
Jasmine Li, Stephen J Turner
Understanding how cell fate decisions are made during cellular differentiation and the mechanisms that drive them is a holy grail of cell biology. In this issue of Immunity, Hu et al. (2018) and Johnson et al. (2018) demonstrate that key transcriptional regulators and global changes in nuclear architecture underlie differentiation decisions during T cell development.
February 20, 2018: Immunity
Gabriele Romano, Sharmeen Chagani, Lawrence N Kwong
The study and comprehension of the molecular mechanisms underlying cancer biology strongly rely on mouse modeling. An ideal mouse model should have molecular, histopathological, and etiological characteristics as close as possible to those of the corresponding human tumors. Among solid tumors, colorectal cancer (CRC) is one of the malignancies that best suits reproduction in an animal model: it evolves through a progressive set of molecular events and is generally associated with a precise histopathology and a neat cataloging of stages and grades...
February 21, 2018: Oncogene
Gloria C Chiang, Ilhami Kovanlikaya, Changho Choi, Rohan Ramakrishna, Rajiv Magge, Dikoma C Shungu
Advances in metabolic imaging techniques have allowed for more precise characterization of gliomas, particularly as it relates to tumor recurrence or pseudoprogression. Furthermore, the emerging field of radiogenomics where radiographic features are systemically correlated with molecular markers has the potential to achieve the holy grail of neuro-oncologic neuro-radiology, namely molecular diagnosis without requiring tissue specimens. In this section, we will review the utility of metabolic imaging and discuss the current state of the art related to the radiogenomics of glioblastoma...
2018: Frontiers in Neurology
Ebru Salmanoglu, Sung Kim, Mathew L Thakur
Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few...
March 2018: Seminars in Nuclear Medicine
Konstantinos Stavropoulos, Konstantinos P Imprialos, Vasilios G Athyros, Michael Doumas
No abstract text is available yet for this article.
February 16, 2018: Journal of Clinical Hypertension
Tiago Rodrigues, Eduardo Infante de Oliveira
No abstract text is available yet for this article.
January 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Sun-Wei Guo
No abstract text is available yet for this article.
February 6, 2018: Human Reproduction
Stefan De Hert, Annelies Moerman
No abstract text is available yet for this article.
January 4, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Lin Chen, Zhennan Huang, Reza Shahbazian-Yassar, Joseph A Libera, Kyle Klavetter, Kevin R Zavadil, Jeffrey W Elam
Lithium metal is considered the "holy grail" of next-generation battery anodes. However, severe parasitic reactions at the lithium-electrolyte interface deplete the liquid electrolyte, and the uncontrolled formation of high surface area and dendritic lithium during cycling cause rapid capacity fading and battery failure. Engineering a dendrite-free lithium metal anode is therefore critical for the development of long-life batteries using lithium anodes. In this study, we deposit a conformal, organic/inorganic hybrid coating, for the first time, directly on lithium metal using molecular layer deposition (MLD) to alleviate these problems...
January 30, 2018: ACS Applied Materials & Interfaces
Todd G Manning, Jonathan S O'Brien, Daniel Christidis, Marlon Perera, Jasamine Coles-Black, Jason Chuen, Damien M Bolton, Nathan Lawrentschuk
PURPOSE: Three-dimensional (3D) printing was invented in 1983 but has only just begun to influence medicine and surgery. Conversion of digital images into physical models demonstrates promise to revolutionize multiple domains of surgery. In the field of uro-oncology, researchers and clinicians have recognized the potential of this technology and are working towards making it an integral part of urological practice. We review current literature regarding 3D printing and other 3D technology in the field of urology...
January 25, 2018: World Journal of Urology
Bo Peng, Yingzi Ming, Cheng Yang
Kidney transplantation is the optimal treatment for end-stage renal diseases. Although great improvement has been achieved, immune tolerance is still the Holy Grail that every organ transplant practitioner pursues. The role of B cells in transplantation has long been considered simply to serve as precursors of plasma cells, which produce alloantibodies and induce antibody-mediated rejection. Recent research indicates that a specialized subset of B cells plays an important role in immune regulation, which has been well demonstrated in autoimmune diseases, infections, and cancers...
January 25, 2018: Cell Death & Disease
Claire Dahyot-Fizelier, Sandrine Marchand, Jeffrey Lipman
No abstract text is available yet for this article.
February 2018: Anaesthesia, Critical Care & Pain Medicine
Silvana Molossi, Carlos M Mery
No abstract text is available yet for this article.
December 9, 2017: Journal of Thoracic and Cardiovascular Surgery
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