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Holy Grail

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https://www.readbyqxmd.com/read/28723214/electrokinetic-manipulation-integrated-plasmonic-photonic-hybrid-raman-nanosensors-with-dually-enhanced-sensitivity
#1
Chao Liu, Zheng Wang, Erwen Li, Zexi Liang, Swapnajit Chakravarty, Xiaochuan Xu, Alan X Wang, Ray T Chen, Donglei Fan
To detect biochemicals with ultrahigh sensitivity, efficiency, reproducibility, and specificity has been the holy grail in the development of nanosensors. In this work, we report an innovative type of photonic-plasmonic hybrid Raman nanosensor integrated with electrokinetic manipulation by rational design, which offers dual mechanisms that enhance the sensitivity for molecule detection directly in solution. For the first time, we integrate large arrays of synthesized plasmonic nanocapsules with densely surface distributed silver (Ag) nanoparticles (NPs) on lithographically patterned photonic crystal slabs via electric-field assembling...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721094/spinal-anesthesia-the-holy-grail
#2
COMMENT
Marieke Voet, Cornelis Slagt
No abstract text is available yet for this article.
2017: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/28698718/the-holy-grail-of-orthopedic-surgery-mesenchymal-stem-cells-their-current-uses-and-potential-applications
#3
REVIEW
Roberto Berebichez-Fridman, Ricardo Gómez-García, Julio Granados-Montiel, Enrique Berebichez-Fastlicht, Anell Olivos-Meza, Julio Granados, Cristina Velasquillo, Clemente Ibarra
Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28697960/what-ails-thee-the-myth-of-the-holy-grail-and-physician-burnout
#4
Nicole Restauri
No abstract text is available yet for this article.
July 8, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28692560/treating-very-early-stage-hcc-have-we-found-the-holy-grail
#5
Po-Hong Liu, Teh-Ia Huo
No abstract text is available yet for this article.
August 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28692342/targeting-the-%C3%AE-4-%C3%AE-5-interface-of-ras-results-in-multiple-levels-of-inhibition
#6
Russell Spencer-Smith, Lie Li, Sheela Prasad, Akiko Koide, Shohei Koide, John P O'Bryan
Generation of RAS-targeted therapeutics has long been considered a "holy grail" in cancer research. However, a lack of binding pockets on the surface of RAS and its picomolar affinity for guanine nucleotides have made isolation of inhibitors particularly challenging. We recently described a monobody, termed NS1, that blocks RAS signaling and oncogenic transformation. NS1 binds to the α4-β6-α5 interface of H-RAS and K-RAS thus preventing RAS dimerization and nanoclustering, which in turn prevents RAS-stimulated dimerization and activation of RAF...
July 10, 2017: Small GTPases
https://www.readbyqxmd.com/read/28689113/current-advances-and-future-visions-on-bioelectronic-immunosensing-for-prostate-specific-antigen
#7
REVIEW
Conlathan Ibau, M K Md Arshad, Subash C B Gopinath
Early cancer diagnosis remains the holy-grail in the battle against cancers progression. Tainted with debates and medical challenges, current therapeutic approaches for prostate cancer (PCa) lack early preventive measures, rapid diagnostic capabilities, risk factors identification, and portability, i.e. the inherent attributes offered by the label-free biosensing devices. Electronic assisted immunosensing systems inherit the high sensitivity and specificity properties due to the predilection of the antigen-antibody affinity...
June 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28688442/perspective-advanced-particle-imaging
#8
David W Chandler, Paul L Houston, David H Parker
Since the first ion imaging experiment [D. W. Chandler and P. L. Houston, J. Chem. Phys. 87, 1445-1447 (1987)], demonstrating the capability of collecting an image of the photofragments from a unimolecular dissociation event and analyzing that image to obtain the three-dimensional velocity distribution of the fragments, the efficacy and breadth of application of the ion imaging technique have continued to improve and grow. With the addition of velocity mapping, ion/electron centroiding, and slice imaging techniques, the versatility and velocity resolution have been unmatched...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28679881/big-data-big-problems-a-healthcare-perspective
#9
Mowafa S Househ, Bakheet Aldosari, Abdullah Alanazi, Andre W Kushniruk, Elizabeth M Borycki
Much has been written on the benefits of big data for healthcare such as improving patient outcomes, public health surveillance, and healthcare policy decisions. Over the past five years, Big Data, and the data sciences field in general, has been hyped as the "Holy Grail" for the healthcare industry promising a more efficient healthcare system with the promise of improved healthcare outcomes. However, more recently, healthcare researchers are exposing the potential and harmful effects Big Data can have on patient care associating it with increased medical costs, patient mortality, and misguided decision making by clinicians and healthcare policy makers...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28674094/is-cardioprotection-dead
#10
REVIEW
David J Lefer, Eduardo Marbán
For >4 decades, the holy grail in the treatment of acute myocardial infarction has been the mitigation of lethal injury. Despite promising initial results and decades of investigation by the cardiology research community, the only treatment with proven efficacy is early reperfusion of the occluded coronary artery. The remarkable record of failure has led us and others to wonder if cardioprotection is dead. The path to translation, like the ascent to Everest, is certainly littered with corpses. We do, however, highlight a therapeutic principle that provides a glimmer of hope: cellular postconditioning...
July 4, 2017: Circulation
https://www.readbyqxmd.com/read/28650131/accommodating-intraocular-lenses
#11
Jay S Pepose, Joshua S Burke, Mujtaba A Qazi
With an explosive increase in the worldwide prevalence of presbyopia, development of an accommodating intraocular lens with expansive accommodative amplitude remains the holy grail in lens-based refractive surgery. A dynamic change in the dioptric power of the eye can be accomplished by various strategies alone or in combination, including changes in the position, shape, or refractive index of a single- or dual- optic intraocular lens (IOL). This article reviews the cumulative advances in these various lens designs, along with clinical outcomes and complications of those that have been implanted...
June 26, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28645815/from-cellular-senescence-to-regeneration-a-quest-for-the-holy-grail-for-the-next-generation-of-surgeons
#12
EDITORIAL
Igor E Konstantinov, Xin Tao Ye, Tyson A Fricke
No abstract text is available yet for this article.
May 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28626365/emergence-of-cd43-expressing-hematopoietic-progenitors-from-human-induced-pluripotent-stem-cells
#13
Katharina U Kessel, Anika Bluemke, Hans R Schöler, Holm Zaehres, Peter Schlenke, Isabel Dorn
BACKGROUND: The ex vivo generation of human hematopoietic stem cells (HSCs) with long-term repopulating capacity and multi-lineage differentiation potential represents the holy grail of hematopoiesis research. In principle, human induced pluripotent stem cells (hiPSCs) provide the tool for both studying molecular mechanisms of hematopoietic development and the ex vivo production of 'true' HSCs for transplantation purposes and lineage-specific cells, e.g. red blood cells, for transfusion purposes...
June 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28621059/biomarkers-in-chronic-pelvic-pain-syndrome-did-we-find-the-holy-grail
#14
EDITORIAL
Thomas M Kessler
No abstract text is available yet for this article.
July 2017: BJU International
https://www.readbyqxmd.com/read/28591641/cardiac-stem-cells-for-myocardial-regeneration-promising-but-not-ready-for-prime-time
#15
REVIEW
Joshua Lader, Maxine Stachel, Lei Bu
Remarkable strides have been made in the treatment of ischemic heart disease in decades. As the initial loss of cardiomyocytes associated with myocardial infarction serves as an impetus for myocardial remodeling, the ability to replace these cells with healthy counterparts would represent an effective treatment for many forms of cardiovascular disease. The discovery of cardiac stem cells (that can differentiate into multiple lineages) highlighted the possibility for development of cell-based therapeutics to achieve this ultimate goal...
June 4, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28577716/articular-cartilage-the-search-for-the-holy-grail-of-treatment-and-restoration
#16
EDITORIAL
Eric C McCarty
No abstract text is available yet for this article.
July 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28570157/preserving-lung-function-the-holy-grail-in-managing-cystic-fibrosis
#17
Peter D Sly, Claire E Wainwright
No abstract text is available yet for this article.
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28566551/outcome-measures-in-the-idiopathic-inflammatory-myopathies-on-the-search-for-the-holy-grail
#18
EDITORIAL
Mazen M Dimachkie, Sabrina Paganoni
No abstract text is available yet for this article.
May 31, 2017: Neurology
https://www.readbyqxmd.com/read/28561695/biomarkers-for-checkpoint-inhibition
#19
Jeffrey S Weber
The identification of predictive biomarkers for the benefit of cancer immunotherapy is the holy grail of the burgeoning immunotherapy field. Recent work has shown that there are a core of concepts that establish the presence of an immune cell-infiltrate, an inflammatory signature of the tumor microenvironment, and the availability of target antigens defined by mutated neoantigens, as critical for the success of the checkpoint blockade. Genetic analyses have shown that resistance to PD-1 blockade, either innate or adaptive, may be due to existing or de novo mutations in signaling pathways critical for T-cell function in a modest proportion of cases...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28553203/autophagy-as-an-emerging-common-pathomechanism-in-inherited-peripheral-neuropathies
#20
REVIEW
Mansour Haidar, Vincent Timmerman
The inherited peripheral neuropathies (IPNs) comprise a growing list of genetically heterogeneous diseases. With mutations in more than 80 genes being reported to cause IPNs, a wide spectrum of functional consequences is expected to follow this genotypic diversity. Hence, the search for a common pathomechanism among the different phenotypes has become the holy grail of functional research into IPNs. During the last decade, studies on several affected genes have shown a direct and/or indirect correlation with autophagy...
2017: Frontiers in Molecular Neuroscience
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