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https://www.readbyqxmd.com/read/29143154/deciphering-the-molecular-events-during-arsenic-induced-transcription-signal-cascade-activation-in-cellular-milieu
#1
REVIEW
Harishkumar Madhyastha, Radha Madhyastha, Yuichi Nakajima, Masugi Maruyama
Anthropogenic sources of arsenic poses and creates unintentional toxico-pathological concerns to humans in many parts of the world. The understanding of toxicity of this metalloid, which shares properties of both metal and non-metal is principally structured on speciation types and holy grail of toxicity prevention. Visible symptoms of arsenic toxicity include nausea, vomiting, diarrhea and abdominal pain. In this review, we focused on the dermal cell stress caused by trivalent arsenic trioxide and pentavalent arsanilic acid...
November 15, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29133405/parallel-magnetic-field-suppresses-dissipation-in-superconducting-nanostrips
#2
Yong-Lei Wang, Andreas Glatz, Gregory J Kimmel, Igor S Aranson, Laxman R Thoutam, Zhi-Li Xiao, Golibjon R Berdiyorov, François M Peeters, George W Crabtree, Wai-Kwong Kwok
The motion of Abrikosov vortices in type-II superconductors results in a finite resistance in the presence of an applied electric current. Elimination or reduction of the resistance via immobilization of vortices is the "holy grail" of superconductivity research. Common wisdom dictates that an increase in the magnetic field escalates the loss of energy since the number of vortices increases. Here we show that this is no longer true if the magnetic field and the current are applied parallel to each other. Our experimental studies on the resistive behavior of a superconducting Mo0...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29127758/-physical-activity-the-holy-grail-of-modern-medicine
#3
Vladimír Tuka, Martina Daňková, Karel Riegel, Martin Matoulek
Movement is the basic attribute of life. It is not surprising that the return to regular physical activity is a very effective and cheap means of preventing and treating most non-cummunicable diseases. Therefore, every physician should be able to prescribe a suitable physical activity. The minimum amount of physical activity with proven effects in primary prevention of chronic diseases is relatively low: 150 minutes of moderate physical activity or 75 minutes of high intensity exercise per week or a combination of the two...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29122939/to-seek-the-holy-grail-of-cardiac-progenitor-cells-an-opera-in-four-acts
#4
EDITORIAL
A J Marian
No abstract text is available yet for this article.
November 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29101996/introduction-biomarkers-of-embryo-viability-the-search-for-the-holy-grail-of-embryo-selection
#5
Zev Rosenwaks
Over the past four decades we have witnessed great progress and increasing pregnancy success rates with in vitro fertilization. However, this apparent success has been accompanied by the burden of multiple pregnancies. While efforts to reduce the number of embryos transferred have had a salutary impact on the incidence of high order multiple pregnancies, twin gestations have not diminished significantly. Thus, the search for a marker of embryo quality with the goal of selecting the single best embryo for transfer continues to be the major challenge facing our field...
November 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29099600/electronic-structure-calculations-and-the-ising-hamiltonian
#6
Rongxin Xia, Teng Bian, Sabre Kais
Obtaining exact solutions to the Schrodinger equation for atoms, molecules and extended systems continues to be a "Holy Grail" problem which the fields of theoretical chemistry and physics have been striving to solve since inception. Recent breakthroughs have been made in the development of hardware-efficient quantum optimizers and coherent Ising machines capable of simulating hundreds of interacting spins with an Ising type Hamiltonian. One of the most vital questions pertaining to these new devices is: "Can these machines be used to perform electronic structure calculations?" Within this work we review the general procedure used by these devices and prove that there is an exact mapping between the electronic structure Hamiltonian and the Ising Hamiltonian...
November 3, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29099451/the-quest-for-the-holy-grail-of-optimizing-mechanical-ventilation-and-protecting-the-lung-in-mechanically-ventilated-infants-and-children
#7
Shekhar T Venkataraman
No abstract text is available yet for this article.
November 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29097308/analysis-of-natural-product-regulation-of-opioid-receptors-in-the-treatment-of-human-disease
#8
REVIEW
S Badal, S Turfus, R Rajnarayanan, C Wilson-Clarke, S L Sandiford
Opioid receptors (ORs), μOR, δOR, κOR and ORL1 mediate numerous signaling cascades, most importantly, through the modulation of ion channels. Research demonstrates the role of OR mediated signal transduction in treating pain, cancer, neurodegenerative disorders and cardiac insults. Yet, the primary application of drugs that modulate ORs is analgesia. Current opioids like morphine that are mainly μOR orthosteric agonists attract many undesirable side-effects (constipation, urinary retention, respiratory depression and hypotension) and the existing modus operandi against these is the inclusion of a μOR antagonist (for example...
October 30, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29097186/rational-design-of-new-materials-using-recombinant-structural-proteins-current-state-and-future-challenges
#9
Tara D Sutherland, Mickey G Huson, Trevor D Rapson
Sequence-definable polymers are seen as a prerequisite for design of future materials, with many polymer scientists regarding such polymers as the holy grail of polymer science. Recombinant proteins are sequence-defined polymers. Proteins are dictated by DNA templates and therefore the sequence of amino acids in a protein is defined, and molecular biology provides tools that allow redesign of the DNA as required. Despite this advantage, proteins are underrepresented in materials science. In this publication we investigate the advantages and limitations of using proteins as templates for rational design of new materials...
October 30, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29096488/exact-molecular-direct-cavity-and-bridge-functions-in-water-system
#10
Luc Belloni
The exact molecular bridge function of the extended simple point charge model of liquid water at room temperature is extracted from Monte Carlo (MC) simulation data. The projections gμν(mnl)(r) onto rotational invariants of the highly directional pair distribution function g(r,Ω) are accumulated during simulation performed with N = 512 molecules (cubic box size L ≈ 25 Å). Making intensive use of anisotropic integral equation techniques, the molecular Ornstein-Zernike equation fed with the MC data available at short distances and completed beyond L/2 with the hypernetted chain closure valid at long distances is then inverted in order to derive on the whole r range the direct correlation function cμν(mnl)(r), the cavity function yμν(mnl)(r), the negative excess potential of mean force lnyμν(mnl)(r), and, finally, the holy grail in such liquid state theory, the bridge function bμν(mnl)(r) projections...
October 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29090936/new-insights-on-the-structure-of-electrochemically-deposited-lithium-metal-and-its-solid-electrolyte-interphases-via-cryogenic-tem
#11
Xuefeng Wang, Minghao Zhang, Judith Alvarado, Shen Wang, Mahsa Sina, Bingyu Lu, James Bouwer, Wu Xu, Jie Xiao, Ji-Guang Zhang, Jun Liu, Ying Shirley Meng
Lithium metal has been considered the "holy grail" anode material for rechargeable batteries despite the fact that its dendritic growth and low Coulombic efficiency (CE) have crippled its practical use for decades. Its high chemical reactivity and low stability make it difficult to explore the intrinsic chemical and physical properties of the electrochemically deposited lithium (EDLi) and its accompanying solid electrolyte interphase (SEI). To prevent the dendritic growth and enhance the electrochemical reversibility, it is crucial to understand the nano- and mesostructures of EDLi...
November 2, 2017: Nano Letters
https://www.readbyqxmd.com/read/29090732/management-of-hypotension-with-vasopressors-at-caesarean-section-under-spinal-anaesthesia-have-we-found-the-holy-grail-of-obstetric-anaesthesia
#12
EDITORIAL
J P Campbell, G M Stocks
No abstract text is available yet for this article.
November 1, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29062478/mesenchymal-stem-cells-in-human-meniscal-regeneration-a-systematic-review
#13
REVIEW
Ernest Chew, Rohan Prakash, Wasim Khan
BACKGROUND: Stem cell regeneration is the holy grail of meniscal tissue repair. Currently, the best treatment is to preserve the original meniscus but if it fails, a partial meniscectomy is indicated to delay the onset of osteoarthritis. MATERIALS AND METHODS: The authors present a systematic review to determine the up-to-date evidence underlying the use of mesenchymal stem cells for meniscal regeneration in humans. A search was conducted using the electronic databases of MEDLINE/Pubmed, Google scholar, and the Cochrane Collaboration...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29036837/simvastatin-as-a-potential-disease-modifying-therapy-for-patients-with-parkinson-s-disease-rationale-for-clinical-trial-and-current-progress
#14
Camille B Carroll, Richard K H Wyse
Many now believe the holy grail for the next stage of therapeutic advance surrounds the development of disease-modifying approaches aimed at intercepting the year-on-year neurodegenerative decline experienced by most patients with Parkinson's disease (PD). Based on recommendations of an international committee of experts who are currently bringing multiple, potentially disease-modifying, PD therapeutics into long-term neuroprotective PD trials, a clinical trial involving 198 patients is underway to determine whether Simvastatin provides protection against chronic neurodegeneration...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29029706/pulmonary-embolism-in-2017-how-we-got-here-and-where-are-we-going
#15
REVIEW
Geno J Merli
In the 1970s, both the Urokinase Pulmonary Embolism and Urokinase-Streptokinase Pulmonary Embolism trials began the quest to develop thrombolytic therapy for the treatment of acute massive and submassive pulmonary embolism (PE). The goals of these studies were the immediate reduction in clot burden, restoration of hemodynamic stability, and improved survival. Major bleeding became the major barrier for clinicians to employ these therapies. From 1980s to the present time, a number of studies using recombinant tissue-type plasminogen activator for achieving these same above outcomes were completed but major bleeding continued to remain an adoption barrier...
September 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/28990197/pollen-tube-growth-and-guidance-occam-s-razor-sharpened-on-a-molecular-arabinogalactan-glycoprotein-rosetta-stone
#16
Derek T A Lamport, Li Tan, Michael Held, Marcia J Kieliszewski
Occam's Razor suggests a new model of pollen tube tip growth based on a novel Hechtian oscillator that integrates a periplasmic arabinogalactan glycoprotein-calcium (AGP-Ca(2+) ) capacitor with tip-localized AGPs as the source of tip-focussed cytosolic Ca(2+) oscillations: Hechtian adhesion between the plasma membrane and the cell wall of the growing tip acts as a piconewton force transducer that couples the internal stress of a rapidly growing wall to the plasma membrane. Such Hechtian transduction opens stretch-activated Ca(2+) channels and activates H(+) -ATPase proton pump efflux that dissociates periplasmic AGP-Ca(2+) resulting in a Ca(2+) influx that activates exocytosis of wall precursors...
October 9, 2017: New Phytologist
https://www.readbyqxmd.com/read/28989836/the-ongoing-quest-for-the-holy-bone-graft-grail-scientific-progress-economic-bonanza-or-quixotic-quagmire
#17
EDITORIAL
Jens R Chapman, Karsten Wiechert, Jeffrey C Wang
No abstract text is available yet for this article.
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28954804/achieving-the-holy-grail-of-emergency-department-evaluation-for-chest-pain
#18
EDITORIAL
Keith E Kocher
No abstract text is available yet for this article.
October 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28952493/biosynthesis-of-inorganic-nanoparticles-a-fresh-look-at-the-control-of-shape-size-and-composition
#19
REVIEW
Si Amar Dahoumane, Clayton Jeffryes, Mourad Mechouet, Spiros N Agathos
Several methodologies have been devised for the design of nanomaterials. The "Holy Grail" for materials scientists is the cost-effective, eco-friendly synthesis of nanomaterials with controlled sizes, shapes and compositions, as these features confer to the as-produced nanocrystals unique properties making them appropriate candidates for valuable bio-applications. The present review summarizes published data regarding the production of nanomaterials with special features via sustainable methodologies based on the utilization of natural bioresources...
February 18, 2017: Bioengineering
https://www.readbyqxmd.com/read/28951091/therapeutic-peptides-for-cns-indications-progress-and-challenges
#20
Bruce H Morimoto
Attacking neurodegeneration and promoting neuroprotection have been the holy grail in neurology for almost 20years and represent an area of high unmet medical need. However, indications like Alzheimer's disease and stroke are areas in drug development fraught with failure. This review will highlight three CNS peptide programs which are tackling targets and indications in which traditional small molecule approaches have been difficult and challenging. The targets for these potential peptide therapeutics include the NMDA receptor, γ-secretase, and cyclin-dependent kinase in which direct inhibition has resulted in on-target (not compound related) problems...
September 9, 2017: Bioorganic & Medicinal Chemistry
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