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https://www.readbyqxmd.com/read/28534784/incorporation-of-solvent-effect-into-multi-objective-evolutionary-algorithm-for-improved-protein-structure-prediction
#1
Shangce Gao, Jiujun Cheng, Yuki Todo, Mengchu Zhou
The problem of predicting the three-dimensional structure of a protein from its one-dimensional sequence has been called the "holy grail of molecular biology", and it has become an important part of structural genomics projects. Despite the rapid developments in computer technology and computational intelligence, it remains challenging and fascinating. In this paper, to solve it we propose a multi-objective evolutionary algorithm. We decompose the protein energy function Chemistry at HARvard Macromolecular Mechanics force fields into bond and non-bond energies as the first and second objectives...
May 17, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28530446/the-temptation-of-forbidden-fruit-and-the-pursuits-of-a-holy-grail
#2
Arthur I Eidelman
No abstract text is available yet for this article.
May 22, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28521905/harnessing-the-properties-of-dendritic-cells-in-the-pursuit-of-immunological-tolerance
#3
REVIEW
Christopher Horton, Kumaran Shanmugarajah, Paul J Fairchild
The acquisition of self-perpetuating, immunological tolerance specific for graft alloantigens has long been described as the "holy grail" of clinical transplantation. By removing the need for life-long immunosuppression following engraftment, the adverse consequences of immunosuppressive regimens, including chronic infections and malignancy, may be avoided. Furthermore, autoimmune diseases and allergy are, by definition, driven by aberrant immunological responses to ordinarily innocuous antigens. The re-establishment of permanent tolerance towards instigating antigens may, therefore, provide a cure to these common diseases...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28512845/work-retirement-and-muscle-strength-loss-in-old-age
#4
Marco Bertoni, Stefania Maggi, Guglielmo Weber
Reduced muscle strength is an accurate predictor of functional limitations, disability, and mortality. Hence, understanding which socio-economic factors contribute to preserve muscle strength in old age is central to the design of social policies that help reducing these health risks. Using data on handgrip strength collected by the Survey of Health, Ageing and Retirement in Europe for the population of Europeans aged 50+ and the exogenous variation in pension eligibility age across countries over time, we estimate that the retirement transition has a short-term positive causal effect on muscle strength...
May 17, 2017: Health Economics
https://www.readbyqxmd.com/read/28495653/in-search-of-the-holy-grail-in-the-channelopathy-field-proving-pathogenicity-of-long-qt-syndrome-associated-variants
#5
EDITORIAL
Arthur A M Wilde, Christopher Semsarian
No abstract text is available yet for this article.
May 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28488907/prediction-the-modern-day-sports-science-medicine-quest-for-the-holy-grail
#6
Alan McCall, Maurizio Fanchini, Aaron J Coutts
In high performance sport, science and medicine practitioners employ a variety of physical and psychological tests, training/match monitoring and injury screening tools for a variety of reasons; mainly to predict performance, identify talented individuals and flag when an injury will occur. The ability to 'predict' outcomes such as performance, talent or injury is arguably the sports science/medicine modern day equivalent of the 'Quest for the Holy Grail'. The purpose of this invited commentary is to 1) highlight the common misinterpretation of studies investigating association to those actually analysing prediction and 2) provide practitioners with simple recommendations to quickly distinguish between methods pertaining to association and those of prediction...
May 10, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28483215/searching-for-the-holy-grail-can-there-ever-be-such-a-thing-as-a-grand-unified-theory-of-sports-performance
#7
A M Williams, P Ward
No abstract text is available yet for this article.
May 5, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28465001/neuroprotection-in-the-treatment-of-acute-ischemic-stroke
#8
REVIEW
Rajan A G Patel, Paul W McMullen
Neuroprotection remains one of the holy grails of acute ischemic stroke therapy. The ability to protect the ischemic brain from injury until reperfusion and then to protect the brain from reperfusion injury could theoretically improve freedom from disability among stroke survivors. This manuscript reviews the molecular and cellular pathophysiology of stroke and summarizes pharmacologic and other therapies that showed promise in pre-clinical testing as neuroprotection agents. However to date, no compelling efficacy data have been published regarding any pharmacologic or other therapies...
April 29, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28430178/endothelial-keratoplasty-is-descemet-membrane-endothelial-keratoplasty-the-holy-grail-of-lamellar-surgery-no
#9
M Tsatsos, V S Liarakos, C MacGregor, I Athanasiadis, E T Detorakis, M M Moschos, P Hossain, D F Anderson
No abstract text is available yet for this article.
April 21, 2017: Eye
https://www.readbyqxmd.com/read/28401962/diamond-like-carbon-coating-under-oleic-acid-lubrication-evidence-for-graphene-oxide-formation-in-superlow-friction
#10
Maria Isabel De Barros Bouchet, Jean Michel Martin, José Avila, Makoto Kano, Kentaro Yoshida, Takeshi Tsuruda, Shandan Bai, Yuji Higuchi, Nobuki Ozawa, Momoji Kubo, Maria C Asensio
The achievement of the superlubricity regime, with a friction coefficient below 0.01, is the Holy Grail of many tribological applications, with the potential to have a remarkable impact on economic and environmental issues. Based on a combined high-resolution photoemission and soft X-ray absorption study, we report that superlubricity can be realized for engineering applications in bearing steel coated with ultra-smooth tetrahedral amorphous carbon (ta-C) under oleic acid lubrication. The results show that tribochemical reactions promoted by the oil lubrication generate strong structural changes in the carbon hybridization of the ta-C hydrogen-free carbon, with initially high sp(3) content...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401258/tumor-associated-myeloid-cells-as-guiding-forces-of-cancer-cell-stemness
#11
REVIEW
Antonio Sica, Chiara Porta, Alberto Amadori, Anna Pastò
Due to their ability to differentiate into various cell types and to support tissue regeneration, stem cells simultaneously became the holy grail of regenerative medicine and the evil obstacle in cancer therapy. Several studies have investigated niche-related conditions that favor stemness properties and increasingly emphasized their association with an inflammatory environment. Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) are major orchestrators of cancer-related inflammation, able to dynamically express different polarized inflammatory programs that promote tumor outgrowth, including tumor angiogenesis, immunosuppression, tissue remodeling and metastasis formation...
April 11, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28374842/dynamic-wavelength-tunable-photodetector-using-subwavelength-graphene-field-effect-transistors
#12
François Léonard, Catalin D Spataru, Michael Goldflam, David W Peters, Thomas E Beechem
Dynamic wavelength tunability has long been the holy grail of photodetector technology. Because of its atomic thickness and unique properties, graphene opens up new paradigms to realize this concept, but so far this has been elusive experimentally. Here we employ detailed quantum transport modeling of photocurrent in graphene field-effect transistors (including realistic electromagnetic fields) to show that wavelength tunability is possible by dynamically changing the gate voltage. We reveal the phenomena that govern the behavior of this type of device and show significant departure from the simple expectations based on vertical transitions...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28373404/precancer-atlas-to-drive-precision-prevention-trials
#13
Avrum Spira, Matthew B Yurgelun, Ludmil Alexandrov, Anjana Rao, Rafael Bejar, Kornelia Polyak, Marios Giannakis, Ali Shilatifard, Olivera J Finn, Madhav Dhodapkar, Neil E Kay, Esteban Braggio, Eduardo Vilar, Sarah A Mazzilli, Timothy R Rebbeck, Judy E Garber, Victor E Velculescu, Mary L Disis, Douglas C Wallace, Scott M Lippman
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology. In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process. The biology of neoplasia caused by germline mutations has led to paradigm-changing precision prevention efforts, including: tumor testing for mismatch repair (MMR) deficiency in Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in familial adenomatous polyposis (FAP), signal of benefit from imaging-based early detection research in high-germline risk for pancreatic neoplasia, elucidating early ontogeny in BRCA1-mutation carriers leading to an international breast cancer prevention trial, and insights into the intricate germline-somatic-immunity interaction landscape...
April 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28336443/predicting-academic-career-placement-neurosurgery-s-quest-for-the-holy-grail
#14
Nickalus R Khan, Paul Klimo, L Madison Michael
No abstract text is available yet for this article.
May 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28332900/fc-or-not-fc-that-is-the-question-antibody-fc-receptor-interactions-are-key-to-universal-influenza-vaccine-design
#15
Sinthujan Jegaskanda, Hillary A Vanderven, Adam K Wheatley, Stephen J Kent
A universal vaccine that provides long-lasting protection from both epidemic and pandemic influenza viruses remains the "holy grail" of influenza vaccine research. Though virus neutralization assays are the current benchmark of measuring vaccine effectiveness, it is clear that Fc-receptor functions can drastically improve the effectiveness of antibodies and vaccines in vivo. Antibodies that kill virus-infected cells and/or elicit an antiviral environment, termed antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies, provide a link between the innate and adaptive immune response...
March 23, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28325042/enhanced-endosomal-escape-by-light-fueled-liquid-metal-transformer
#16
Yue Lu, Yiliang Lin, Zhaowei Chen, Quanyin Hu, Yang Liu, Shuangjiang Yu, Wei Gao, Michael D Dickey, Zhen Gu
Effective endosomal escape remains as the "holy grail" for endocytosis-based intracellular drug delivery. To date, most of the endosomal escape strategies rely on small molecules, cationic polymers, or pore-forming proteins, which are often limited by the systemic toxicity and lack of specificity. We describe here a light-fueled liquid-metal transformer for effective endosomal escape-facilitated cargo delivery via a chemical-mechanical process. The nanoscale transformer can be prepared by a simple approach of sonicating a low-toxicity liquid-metal...
April 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28294256/the-lab-on-pcb-approach-tackling-the-%C3%AE-tas-commercial-upscaling-bottleneck
#17
REVIEW
Despina Moschou, Angeliki Tserepi
Commercialization of lab-on-a-chip devices is currently the "holy grail" within the μTAS research community. While a wide variety of highly sophisticated chips which could potentially revolutionize healthcare, biology, chemistry and all related disciplines are increasingly being demonstrated, very few chips are or can be adopted by the market and reach the end-users. The major inhibition factor lies in the lack of an established commercial manufacturing technology. The lab-on-printed circuit board (lab-on-PCB) approach, while suggested many years ago, only recently has re-emerged as a very strong candidate, owing to its inherent upscaling potential: the PCB industry is well established all around the world, with standardized fabrication facilities and processes, but commercially exploited currently only for electronics...
April 11, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28252256/arrhythmic-risk-stratification-in-heart-failure-time-for-the-next-step
#18
REVIEW
Konstantinos A Gatzoulis, Antonios Sideris, Emmanuel Kanoupakis, Skevos Sideris, Nikolaos Nikolaou, Christos-Konstantinos Antoniou, Theofilos M Kolettis
BACKGROUND: Primary prevention of sudden cardiac death by means of implantable cardioverter-defibrillators constitutes the holy grail of arrhythmology. However, current risk stratification algorithms lead to suboptimal outcomes, by both allocating ICDs to patients not deriving any meaningful survival benefit and withholding them from those erroneously considered as low-risk for arrhythmic mortality. METHODS: In the present review article we will attempt to present shortcomings of contemporary guidelines regarding sudden death prevention in ischemic and dilated cardiomyopathy patients and present available data suggesting encouraging results following implementation of multifactorial approaches, by using multiple modalities, both noninvasive and invasive...
March 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28248138/maintaining-the-benefits-of-pulmonary-rehabilitation-the-holy-grail
#19
Carolyn L Rochester, Martijn A Spruit
No abstract text is available yet for this article.
March 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28240525/infrapopliteal-calcification-patterns-in-critical-limb-ischemia-diagnostic-pathologic-and-therapeutic-implications-in-the-search-for-the-endovascular-holy-grail
#20
REVIEW
Jihad A Mustapha, Larry J Diaz-Sandoval, Fadi Saab
Critical limb ischemia (CLI) represents the terminal stage of peripheral arterial disease (PAD) and is characterized by multilevel and multivessel disease. Amongst patients with infrainguinal disease, approximately one third have predominantly isolated infrapopliteal disease and the remaining two thirds, a combination of femoropopliteal and infrapopliteal disease. Isolated infrapopliteal disease is mainly seen in the elderly, diabetic, or dialysis-dependent patients. These patients have higher risk of amputation and shorter amputation-free survival...
June 2017: Journal of Cardiovascular Surgery
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