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https://www.readbyqxmd.com/read/28912890/glioma-dual-targeting-nanohybrid-protein-toxin-constructed-by-intein-mediated-site-specific-ligation-for-multistage-booster-delivery
#1
Yingzhi Chen, Meng Zhang, Hongyue Jin, Dongdong Li, Fan Xu, Aihua Wu, Jinyu Wang, Yongzhuo Huang
Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the impermeable nature of BBB against effective delivery of biologics. Indeed, it is a long unsolved problem for brain delivery of macromolecular drugs, which becomes the Holy Grail in medical and pharmaceutical sciences...
2017: Theranostics
https://www.readbyqxmd.com/read/28868626/columnar-lithium-metal-anodes
#2
Xue-Qiang Zhang, Xiang Chen, Rui Xu, Xin-Bing Cheng, Hong-Jie Peng, Rui Zhang, Jia-Qi Huang, Qiang Zhang
Rechargeable lithium (Li) metal anode is regarded as the "Holy Grail" for high-energy-density batteries. Regulating the deposition/dissolution characteristics of Li metal is critical in both fundamental research and practical applications. In contrast to grey Li deposits featured with dendritic and mossy morphologies, columnar and uniform Li is herein plated on lithium-fluoride (LiF)-protected copper (Cu) current collectors. The electrochemical properties strongly depended on the microscale morphologies of deposited Li, which were further embodied as macroscale colors...
September 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28834039/molecular-catalysts-for-n2-reduction-state-of-the-art-mechanism-and-challenges
#3
Yoann Roux, Carole Duboc, Marcello Gennari
Fixation of atmospheric nitrogen is central for the production of ammonia, which is the source of nitrogen fertilizers and is also emerging as a promising renewable fuel. While the development of efficient molecular-based artificial nitrogen fixation systems working under mild conditions is probably a Holy Grail, catalytic reduction of N2 by transition metal complexes is above all the main instrument to progress in mechanistic understanding of N2 splitting. In this minireview we first give an overview of molecular-based catalytic systems, including recent breakthroughs, and then we illustrate the alternative pathways for N2 reduction...
August 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28826736/-what-biomarkers-for-the-future-the-point-of-view-of-the-residents-in-oncology-after-the-esmo-2016-congress
#4
REVIEW
Marie Auvray, Marc-Antoine Benderra, Marie Bretagne, Sara Faouzi, Loïc Lebellec, Linda Majhoubi, Mathilde Saint-Ghislain, Stéphane Vignot
Since the advent of the HER2 biomarker allowing access to treatment with trastuzumab, we observe an explosion in research for biomarkers, in which the economic pressure linked to the costs of developing new products must not be overlooked, in order to better select the molecules to be developed and the patients who can benefit from them. Personalized medicine takes a little more space each year in the overall care of our patients and the search for specific indicators, has become unavoidable. Rapid identification of oncogenic changes, their therapeutic targeting and the anticipation of resistance or toxicity mechanisms is a challenge...
August 18, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28806533/reaching-for-the-holy-grail-of-copd-outcomes-can-medications-modify-lung-function-decline
#5
Shawn D Aaron
No abstract text is available yet for this article.
August 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28805723/hitting-the-holy-grail-of-hematopoietic-cell-transplantation-with-naive-t-cell-depleted-allografts-graft-engineered-hematopoietic-stem-cell-transplant
#6
Riad El Fakih, Shahrukh K Hashmi
Hematopoietic cell transplant is a potentially curative procedure for many benign and malignant conditions. The efficacy of allogeneic transplant relies in part on the cytotoxicity of the conditioning regimen and the graft versus tumor effect mediated by alloreactive donor T cells; the same cells are also implicated in the development of graft versus host disease (GVHD). Selective identification and depletion of the T cells implicated in GVHD, while preserving the T cells responsible for graft versus tumor effect has been the focus of many research groups in the recent years...
August 14, 2017: Biomedicines
https://www.readbyqxmd.com/read/28802609/another-quest-for-the-holy-grail-of-abolishing-post-operative-nausea-and-vomiting
#7
EDITORIAL
Vahe Tateosian, Tong J Gan
No abstract text is available yet for this article.
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28776627/review-of-the-progress-toward-achieving-heat-confinement-the-holy-grail-of-photothermal-therapy
#8
Wangzhong Sheng, Sha He, William J Seare, Adah Almutairi
Photothermal therapy (PTT) involves the application of normally benign light wavelengths in combination with efficient photothermal (PT) agents that convert the absorbed light to heat to ablate selected cancers. The major challenge in PTT is the ability to confine heating and thus direct cellular death to precisely where PT agents are located. The dominant strategy in the field has been to create large libraries of PT agents with increased absorption capabilities and to enhance their delivery and accumulation to achieve sufficiently high concentrations in the tissue targets of interest...
August 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28776047/an-interoperable-similarity-based-cohort-identification-method-using-the-omop-common-data-model-version-5-0
#9
Shreya Chakrabarti, Anando Sen, Vojtech Huser, Gregory W Hruby, Alexander Rusanov, David J Albers, Chunhua Weng
Cohort identification for clinical studies tends to be laborious, time-consuming, and expensive. Developing automated or semi-automated methods for cohort identification is one of the "holy grails" in the field of biomedical informatics. We propose a high-throughput similarity-based cohort identification algorithm by applying numerical abstractions on Electronic Health Records (EHR) data. We implement this algorithm using the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM), which enables sites using this standardized EHR data representation to avail this algorithm with minimum effort for local implementation...
June 2017: J Healthc Inform Res
https://www.readbyqxmd.com/read/28771325/silicon-tethered-strategies-for-c-h-functionalization-reactions
#10
Marvin Parasram, Vladimir Gevorgyan
Selective and efficient functionalization of ubiquitous C-H bonds is the Holy Grail of organic synthesis. Most advances in this area rely on employment of strongly or weakly coordinating directing groups (DGs) which have proven effective for transition-metal-catalyzed functionalization of C(sp(2))-H and C(sp(3))-H bonds. Although most directing groups are important functionalities in their own right, in certain cases, the DGs become static entities that possess very little synthetic leverage. Moreover, some of the DGs employed are cumbersome or unpractical to remove, which precludes the use of this approach in synthesis...
August 3, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28770214/cardiac-stem-cells-for-myocardial-regeneration-they-are-not-alone
#11
REVIEW
Yin Yee Leong, Wai Hoe Ng, Georgina M Ellison-Hughes, Jun Jie Tan
Heart failure is the number one killer worldwide with ~50% of patients dying within 5 years of prognosis. The discovery of stem cells, which are capable of repairing the damaged portion of the heart, has created a field of cardiac regenerative medicine, which explores various types of stem cells, either autologous or endogenous, in the hope of finding the "holy grail" stem cell candidate to slow down and reverse the disease progression. However, there are many challenges that need to be overcome in the search of such a cell candidate...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28764666/a-mega-ethnography-of-eleven-qualitative-evidence-syntheses-exploring-the-experience-of-living-with-chronic-non-malignant-pain
#12
Fran Toye, Kate Seers, Erin Hannink, Karen Barker
BACKGROUND: Each year over five million people develop chronic non-malignant pain and can experience healthcare as an adversarial struggle. The aims of this study were: (1) to bring together qualitative evidence syntheses that explore patients' experience of living with chronic non-malignant pain and develop conceptual understanding of what it is like to live with chronic non-malignant pain for improved healthcare; (2) to undertake the first mega-ethnography of qualitative evidence syntheses using the methods of meta-ethnography...
August 1, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28761734/immune-checkpoint-inhibitors-in-lung-cancer-the-holy-grail-has-not-yet-been-found%C3%A2
#13
EDITORIAL
Satheesh Thungappa, Jose Ferri, Christian Caglevic, Francesco Passiglia, Luis Raez, Christian Rolfo
No abstract text is available yet for this article.
2017: ESMO Open
https://www.readbyqxmd.com/read/28740645/immunosuppression-after-lung-transplantation-the-search-for-the-holy-grail-continues
#14
EDITORIAL
Stefan Schwarz, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28737903/transition-metal-functionalization-of-p4-using-a-diarylgermylene-anchor
#15
Cameron M E Graham, Charles L B Macdonald, Philip P Power, Zachary D Brown, Paul J Ragogna
The manipulation of white phosphorus (P4) has been a long-standing challenge for chemists. While the holy grail remains at finding a method to catalytically activate and functionalize P4 to yield new organophosphorus compounds, fundamental research lies in developing procedures to control the reactivity of elemental phosphorus. In this work, Lewis acidic transition metal moieties M(CO)5 (M = Cr, Mo, W) and AuCl react with P4 derivatized with a low valent germanium compound. For both M(CO)5 and AuCl, bis-functionalized products can be formed; however the monosubstituted derivatives are found to be more stable, and the decomposition can be monitored by (31)P{(1)H} NMR spectroscopy...
August 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28734388/axonal-transport-dysfunction-in-neurodegenerative-diseases-the-holy-grail-for-developing-disease-modifying-therapies
#16
EDITORIAL
Jennifer T Lamberts, Patrik Brundin
No abstract text is available yet for this article.
September 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28723214/electrokinetic-manipulation-integrated-plasmonic-photonic-hybrid-raman-nanosensors-with-dually-enhanced-sensitivity
#17
Chao Liu, Zheng Wang, Erwen Li, Zexi Liang, Swapnajit Chakravarty, Xiaochuan Xu, Alan X Wang, Ray T Chen, Donglei Fan
To detect biochemicals with ultrahigh sensitivity, efficiency, reproducibility, and specificity has been the holy grail in the development of nanosensors. In this work, we report an innovative type of photonic-plasmonic hybrid Raman nanosensor integrated with electrokinetic manipulation by rational design, which offers dual mechanisms that enhance the sensitivity for molecule detection directly in solution. For the first time, we integrate large arrays of synthesized plasmonic nanocapsules with densely surface distributed silver (Ag) nanoparticles (NPs) on lithographically patterned photonic crystal slabs via electric-field assembling...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721094/spinal-anesthesia-the-holy-grail
#18
COMMENT
Marieke Voet, Cornelis Slagt
No abstract text is available yet for this article.
2017: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/28698718/the-holy-grail-of-orthopedic-surgery-mesenchymal-stem-cells-their-current-uses-and-potential-applications
#19
REVIEW
Roberto Berebichez-Fridman, Ricardo Gómez-García, Julio Granados-Montiel, Enrique Berebichez-Fastlicht, Anell Olivos-Meza, Julio Granados, Cristina Velasquillo, Clemente Ibarra
Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28697960/what-ails-thee-the-myth-of-the-holy-grail-and-physician-burnout
#20
Nicole Restauri
No abstract text is available yet for this article.
July 8, 2017: Journal of the American College of Radiology: JACR
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