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Holy Grail

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https://www.readbyqxmd.com/read/28212756/the-holy-grail-solid-tumor-efficacy-by-proteasome-inhibition
#1
Mark Rolfe
Proteasome inhibitors have revolutionized the treatment of multiple myeloma but have had disappointing results when treating solid tumors. The work of Weyburne et al. (2017), published in this issue of Cell Chemical Biology, sheds some light on this conundrum and suggests a novel approach to achieve solid tumor efficacy.
February 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28209566/the-holy-grail-of-health-and-social-care-integration
#2
EDITORIAL
Jon Glasby
No abstract text is available yet for this article.
February 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28203746/videolaryngoscopy-and-the-search-for-the-holy-grail
#3
F Sgalambro, M Sorbello
No abstract text is available yet for this article.
March 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28197563/the-secret-behind-the-success-of-doping-nickel-oxyhydroxide-with-iron
#4
Vicky Fidelsky, Maytal Caspary Toroker
Discovering better catalysts for water splitting is the holy grail of the renewable energy field. One of the most successful water oxidation catalysts is nickel oxyhydroxide (NiOOH), which is chemically active only as a result of doping with Fe. In order to shed light on how Fe improves efficiency, we perform Density Functional Theory +U (DFT+U) calculations of water oxidation reaction intermediates of Fe substitutional doped NiOOH. The results are analyzed while considering the presence of vacancies that we use as probes to test the effect of adding charge to the surface...
February 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28149886/anticoagulant-independent-mechanical-heart-valves-viable-now-or-still-a-distant-holy-grail
#5
Aurelio Chaux, Richard J Gray, Jonathan C Stupka, Michael R Emken, Lawrence N Scotten, Rolland Siegel
Valvular heart disease remains a large public health problem for all societies; it attracts the attention of public health organizations, researchers and governments. Valve substitution is an integral part of the treatment for this condition. At present, the choice of valve prosthesis is either tissue or mechanical. Tissue valves have become increasingly popular in spite of unresolved problems with durability, hemodynamics, cost and need for anticoagulation therapy. As a consequence, mechanical valve innovation has virtually ceased; the last successful mechanical design is 25 years old...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28149878/in-search-for-the-holy-grail-of-cough-guidelines
#6
EDITORIAL
Anne B Chang
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28146309/giving-up-on-precision-oncology-not-so-fast
#7
REVIEW
Jeremy L Warner
The vision of matching the right patient to the right treatment at the right time has always been the holy grail of oncology. Until recently, very few cancer patients enjoyed the benefits of truly "personalized" a.k.a. precision therapy. With the exploding knowledge of tumor genotype, as well as increasingly available targeted treatment options, it seems that the era of precision cancer medicine is nigh. However, as with many new paradigms, there has been substantial pushback. This article is protected by copyright...
February 1, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28103787/lessons-learned-from-two-decades-of-clinical-trial-experience-in-gene-therapy-for-fanconi-anemia
#8
Jennifer E Adair, Julian Sevilla, Cristina Díaz de Heredia, Pamela S Becker, Hans-Peter Kiem, Juan Bueren
Allogeneic hematopoietic stem cell transplant is the only curative treatment for patients with the non-malignant bone marrow failure syndrome called Fanconi anemia (FA). However, early and late complications associated with this approach underscore the need for alternative treatments. Gene therapy approaches aiming to correct the genetic defect in the patient's own hematopoietic stem cells remain the most promising strategy to overcome FA-associated bone marrow failure. Yet, despite more than two decades of clinical research, a therapeutic "success" has not yet been achieved...
January 19, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28100006/the-fingerprint-of-antimitochondrial-antibodies-and-the-etiology-of-primary-biliary-cholangitis
#9
Zongwen Shuai, Jinjun Wang, Madhu Badamagunta, Jinjung Choi, Guoxiang Yang, Weici Zhang, Thomas P Kenny, Kathryn Guggenheim, Mark J Kurth, Aftab A Ansari, John Voss, Ross L Coppel, Pietro Invernizzi, Patrick S C Leung, M Eric Gershwin
The identification of environmental factors that lead to loss of tolerance has been coined the Holy Grail of autoimmunity. Our work has focused on the reactivity of antimitochondrial autoantibodies (AMA) to chemical xenobiotics and has hypothesized that a modified peptide within PDC-E2, the major mitochondrial autoantigen, will have been immunologically recognized at the time of loss of tolerance. Herein we successfully applied intein technology to construct a PDC-E2 protein fragment containing amino acid residues 177-314 of PDC-E2 by joining a recombinant peptide spanning residues 177 to 252 (PDC-228) with a 62 residue synthetic peptide from 253 to 314 (PP), which encompasses PDC-E2 ILD...
January 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28078238/liquid-biopsies-in-bladder-cancer-did-we-find-the-holy-grail-for-biomarker-analyses
#10
EDITORIAL
Michael Rink, Shahrokh F Shariat, Armin Soave
No abstract text is available yet for this article.
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28030445/mechanical-circulatory-support-and-antithrombotic-therapy-looking-for-the-holy-grail
#11
M Patricia Massicotte, Timothy M Maul, Trevor A Snyder, Lisa Baumann Kreuziger
No abstract text is available yet for this article.
January 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27990753/triangle-of-marcille-the-anatomical-gateway-to-lateral-pelvic-exenteration
#12
Peter Lee, Katherine E Francis, Michael J Solomon, George Ramsey-Stewart, Kirk K S Austin, Cherry Koh
BACKGROUND: To perform more radical surgery for complex pelvic malignancies and recurrent colorectal cancer, the surgeon must increasingly operate outside the conventional anatomical planes. Published in 1963 the 'Triangle of Marcille' (lumbosacral triangle) remained primarily of intellectual interest being found lateral to the traditional operating field. However, with the advancement of complex colorectal and gynaecological surgery it now provides a schema to assist surgeons in becoming acquainted with a complex and poorly understood anatomical region...
December 18, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27989575/the-holy-grail-of-hiv-programme-effectiveness
#13
Sunil Suhas Solomon
No abstract text is available yet for this article.
December 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27981540/sleeve-gastrectomy-have-we-finally-found-the-holy-grail-of-bariatric-surgery-a-review-of-the-literature
#14
I Kehagias, A Zygomalas, D Karavias, S Karamanakos
OBJECTIVE: Laparoscopic sleeve gastrectomy has become one of the most commonly performed bariatric operations. It is essentially a restrictive bariatric operation; however, a series of hormonal changes occurring postoperatively contribute to decreased appetite and reduced food intake. PATIENTS AND METHODS: This is a literature review of recent articles published on Pubmed, Medline and Google Scholar databases in English. RESULTS: Although, laparoscopic sleeve gastrectomy is commonly performed worldwide, there is still a lack of standardization regarding the surgical technique...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27966238/mechanisms-and-possible-controls-of-the-in-utero-zika-virus-infection-where-is-the-holy-grail
#15
Kazumasa Fuwa, Satoshi Hayakawa
Zika virus infection (ZVI) is a great concern for human health because it frequently causes fetal anomalies. Little is known about pathophysiology of ZVI because it has been regarded as a mild, no life-threatening infection. However, the latest endemic in South and Central America took attention of perinatologists, microbiologists, and pathologists. Both in vivo and in vitro studies suggest neurotropic nature of Zika virus but do not clarify viral kinetics during vertical transmissions. In this review, we focus on the clinical and microbiological natures ZVI for pregnant women especially how placental barriers are broken down...
December 14, 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27928016/promising-role-of-toll-like-receptor-8-agonist-in-concert-with-prostratin-for-activation-of-silent-hiv
#16
M A Rochat, E Schlaepfer, R F Speck
: The persistence of latently HIV-infected cells in patients under combined antiretroviral treatment (cART) remains the major hurdle for HIV eradication. Thus far, individual compounds have not been sufficiently potent to reactivate latent virus and guarantee its elimination in vivo. Thus, we hypothesized that transcriptional enhancers, in concert with compounds triggering the innate immune system, are more efficient in reversing latency by creating a Th1 supportive milieu that acts against latently HIV-infected cells at various levels...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27916848/water-will-be-the-coal-of-the-future-the-untamed-dream-of-jules-verne-for-a-solar-fuel
#17
REVIEW
Vladimir K Ryabchuk, Vyacheslav N Kuznetsov, Alexei V Emeline, Yurii M Artem'ev, Galina V Kataeva, Satoshi Horikoshi, Nick Serpone
This article evokes the futuristic visions of two giants, one a writer, Jules Verne, who foresaw water as the coal of the future, and the other a scientist, Giacomo Ciamician, who foresaw the utilization of solar energy as an energy source with which to drive photochemical and photocatalytic reactions for the betterment of mankind. Specifically, we examine briefly the early work of the 1960s and 1970s on the photosplitting of free water and water adsorbed on solid supports, based mostly on metal oxides, from which both hydrogen and oxygen evolve in the expected stoichiometric ratio of 2 to 1...
November 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27896197/a-refined-technique-for-management-of-nasal-flaring-the-quest-for-the-holy-grail-of-alar-base-modification
#18
Kapil S Agrawal, Mansi Pabari, Raghav Shrotriya
"A smile is happiness you'll find right under your nose"- Tom Wilson. This quote holds true just for patients, not for surgeons. The correction of the nose always poses a challenge to the cosmetic surgeon. Deformities of the external and internal nose may be congenital or acquired and may be secondary to soft tissue and/or osseo-cartilaginous abnormalities, leading to aesthetic and/or functional consequences. Alar flare poses a common problem, sometimes alone and sometimes in conjunction with other external deformities...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27872445/searching-for-mechanical-abnormalities-in-subjects-with-early-repolarization-pattern-another-holy-grail-of-cardiac-imaging
#19
EDITORIAL
Ivan Stankovic
No abstract text is available yet for this article.
November 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27865185/a-new-era-in-the-management-of-type-2-diabetes-is-cardioprotection-at-long-last-a-reality
#20
EDITORIAL
Xavier Rossello, Derek M Yellon
The EMPA-REG OUTCOME and the LEADER trials have revealed a new era in the management of type 2 diabetes. The SGLT2 inhibitor empagliflozin demonstrated a lower rate of the primary composite outcome of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke compared to placebo. Liraglutide, a GLP-1 analogue, succeeded to demonstrate reduction on a composite outcome including first occurrence of cardiovascular death, nonfatal myocardial infarction or non-fatal stroke. These two medications act through different mechanisms and has consequently shown different patterns of cardiovascular benefit...
February 1, 2017: International Journal of Cardiology
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