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Holy Grail

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https://www.readbyqxmd.com/read/28100006/the-fingerprint-of-antimitochondrial-antibodies-and-the-etiology-of-primary-biliary-cholangitis
#1
Zongwen Shuai, Jinjun Wang, Madhu Badamagunta, Jinjung Choi, Guoxiang Yang, Weici Zhang, Thomas P Kenny, Kathryn Guggenheim, Mark J Kurth, Aftab A Ansari, John Voss, Ross L Coppel, Pietro Invernizzi, Patrick S C Leung, M Eric Gershwin
The identification of environmental factors that lead to loss of tolerance has been coined the Holy Grail of autoimmunity. Our work has focused on the reactivity of antimitochondrial autoantibodies (AMA) to chemical xenobiotics and has hypothesized that a modified peptide within PDC-E2, the major mitochondrial autoantigen, will have been immunologically recognized at the time of loss of tolerance. Herein we successfully applied intein technology to construct a PDC-E2 protein fragment containing amino acid residues 177-314 of PDC-E2 by joining a recombinant peptide spanning residues 177 to 252 (PDC-228) with a 62 residue synthetic peptide from 253 to 314 (PP), which encompasses PDC-E2 ILD...
January 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28078238/liquid-biopsies-in-bladder-cancer-did-we-find-the-holy-grail-for-biomarker-analyses
#2
EDITORIAL
Michael Rink, Shahrokh F Shariat, Armin Soave
No abstract text is available yet for this article.
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28030445/mechanical-circulatory-support-and-antithrombotic-therapy-looking-for-the-holy-grail
#3
M Patricia Massicotte, Timothy M Maul, Trevor A Snyder, Lisa Baumann Kreuziger
No abstract text is available yet for this article.
January 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27990753/triangle-of-marcille-the-anatomical-gateway-to-lateral-pelvic-exenteration
#4
Peter Lee, Katherine E Francis, Michael J Solomon, George Ramsey-Stewart, Kirk K S Austin, Cherry Koh
BACKGROUND: To perform more radical surgery for complex pelvic malignancies and recurrent colorectal cancer, the surgeon must increasingly operate outside the conventional anatomical planes. Published in 1963 the 'Triangle of Marcille' (lumbosacral triangle) remained primarily of intellectual interest being found lateral to the traditional operating field. However, with the advancement of complex colorectal and gynaecological surgery it now provides a schema to assist surgeons in becoming acquainted with a complex and poorly understood anatomical region...
December 18, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27989575/the-holy-grail-of-hiv-programme-effectiveness
#5
Sunil Suhas Solomon
No abstract text is available yet for this article.
December 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27981540/sleeve-gastrectomy-have-we-finally-found-the-holy-grail-of-bariatric-surgery-a-review-of-the-literature
#6
I Kehagias, A Zygomalas, D Karavias, S Karamanakos
OBJECTIVE: Laparoscopic sleeve gastrectomy has become one of the most commonly performed bariatric operations. It is essentially a restrictive bariatric operation; however, a series of hormonal changes occurring postoperatively contribute to decreased appetite and reduced food intake. PATIENTS AND METHODS: This is a literature review of recent articles published on Pubmed, Medline and Google Scholar databases in English. RESULTS: Although, laparoscopic sleeve gastrectomy is commonly performed worldwide, there is still a lack of standardization regarding the surgical technique...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27966238/mechanisms-and-possible-controls-of-the-in-utero-zika-virus-infection-where-is-the-holy-grail
#7
Kazumasa Fuwa, Satoshi Hayakawa
Zika virus infection (ZVI) is a great concern for human health because it frequently causes fetal anomalies. Little is known about pathophysiology of ZVI because it has been regarded as a mild, no life-threatening infection. However, the latest endemic in South and Central America took attention of perinatologists, microbiologists, and pathologists. Both in vivo and in vitro studies suggest neurotropic nature of Zika virus but do not clarify viral kinetics during vertical transmissions. In this review, we focus on the clinical and microbiological natures ZVI for pregnant women especially how placental barriers are broken down...
December 14, 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27928016/promising-role-of-toll-like-receptor-8-agonist-in-concert-with-prostratin-for-activation-of-silent-hiv
#8
M A Rochat, E Schlaepfer, R F Speck
: The persistence of latently HIV-infected cells in patients under combined anti-retroviral treatment (cART) remains the major hurdle for HIV eradication. Thus far, individual compounds have not been sufficiently potent to reactivate latent virus and guarantee its elimination in vivo Thus, we hypothesized that transcriptional enhancers, in concert with compounds triggering the innate immune system, are more efficient in reversing latency by creating a Th1 supportive milieu that acts against latently HIV-infected cells at various levels...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27916848/water-will-be-the-coal-of-the-future-the-untamed-dream-of-jules-verne-for-a-solar-fuel
#9
REVIEW
Vladimir K Ryabchuk, Vyacheslav N Kuznetsov, Alexei V Emeline, Yurii M Artem'ev, Galina V Kataeva, Satoshi Horikoshi, Nick Serpone
This article evokes the futuristic visions of two giants, one a writer, Jules Verne, who foresaw water as the coal of the future, and the other a scientist, Giacomo Ciamician, who foresaw the utilization of solar energy as an energy source with which to drive photochemical and photocatalytic reactions for the betterment of mankind. Specifically, we examine briefly the early work of the 1960s and 1970s on the photosplitting of free water and water adsorbed on solid supports, based mostly on metal oxides, from which both hydrogen and oxygen evolve in the expected stoichiometric ratio of 2 to 1...
November 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27896197/a-refined-technique-for-management-of-nasal-flaring-the-quest-for-the-holy-grail-of-alar-base-modification
#10
Kapil S Agrawal, Mansi Pabari, Raghav Shrotriya
"A smile is happiness you'll find right under your nose"- Tom Wilson. This quote holds true just for patients, not for surgeons. The correction of the nose always poses a challenge to the cosmetic surgeon. Deformities of the external and internal nose may be congenital or acquired and may be secondary to soft tissue and/or osseo-cartilaginous abnormalities, leading to aesthetic and/or functional consequences. Alar flare poses a common problem, sometimes alone and sometimes in conjunction with other external deformities...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27872445/searching-for-mechanical-abnormalities-in-subjects-with-early-repolarization-pattern-another-holy-grail-of-cardiac-imaging
#11
EDITORIAL
Ivan Stankovic
No abstract text is available yet for this article.
November 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27865185/a-new-era-in-the-management-of-type-2-diabetes-is-cardioprotection-at-long-last-a-reality
#12
EDITORIAL
Xavier Rossello, Derek M Yellon
The EMPA-REG OUTCOME and the LEADER trials have revealed a new era in the management of type 2 diabetes. The SGLT2 inhibitor empagliflozin demonstrated a lower rate of the primary composite outcome of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke compared to placebo. Liraglutide, a GLP-1 analogue, succeeded to demonstrate reduction on a composite outcome including first occurrence of cardiovascular death, nonfatal myocardial infarction or non-fatal stroke. These two medications act through different mechanisms and has consequently shown different patterns of cardiovascular benefit...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27834559/wearable-training-monitoring-technology-applications-challenges-and-opportunities
#13
Marco Cardinale, Matthew C Varley
The need to quantify aspects of training in order to improve training prescription has been the holy grail of sport scientists and coaches for many years. Recently, there has been an increase in scientific interest, possibly due to technological advancements and better equipment to quantify training activities. Over the last few years there has been an increase in the number of studies assessing training load in various athletic cohorts with a bias towards subjective reports and/or quantifications of external load...
November 11, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27828048/efficient-compressed-imaging-method-for-a-microsatellite-optical-camera
#14
Jin Li, Zilong Liu
Imaging integrated with compression is considered the holy grail of microsatellite photography because it improves the degree of integration of the camera system, removing the compression system, high capacity storage system, and high-speed image transmission system, which consume lots of resources of the satellite platform. In this paper, we propose an efficient compressed imaging method for remote sensing photography. We consider wavelet coefficients as pixels of a block-wise megapixel sensor (BMPS). We integrate the saliency information stage into the BMPS to perform compressed sampling (CS) in order to further improve imaging performance...
October 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27824889/ocean-productivity-may-predict-recruitment-of-the-rainbow-wrasse-coris-julis
#15
Jorge Fontes, Brice Semmens, Jennifer E Caselle, Ricardo S Santos, Shree R Prakya
Predicting recruitment fluctuations of fish populations remains the Holy Grail of fisheries science. While previous work has linked recruitment of reef fish to environmental variables including temperature, the demonstration of a robust relationship with productivity remains elusive. Despite decades of research, empirical evidence to support this critical link remains limited. Here we identify a consistent and strong relationship between recruitment of a temperate wrasse Coris julis, from temperate reefs in the mid-Atlantic region, with Chlorophyll, over contrasting scales, across multiple years...
2016: PloS One
https://www.readbyqxmd.com/read/27793288/single-molecule-fluorescence-studies-of-fast-protein-folding
#16
Z Wang, L A Campos, V Muñoz
Watching the conformational wanderings of protein molecules during their search for their native structure is a holy grail for protein folding experimentalists. Such capability is essential to provide reality checks to the complex mechanistic heterogeneity that theory and molecular simulations predict. Single-molecule fluorescence resonance energy transfer (SM-FRET) is an attractive technique to meet that end, but its time resolution was insufficient for the microsecond motions of folding proteins. The temporal resolution of SM-FRET pivots on how quickly photons emitted by an individual molecule can be collected in sufficient numbers as to minimize statistical shot noise...
2016: Methods in Enzymology
https://www.readbyqxmd.com/read/27768849/use-of-physiologically-based-kinetic-modeling-based-reverse-dosimetry-to-predict-in-vivo-toxicity-from-in-vitro-data
#17
Jochem Louisse, Karsten Beekmann, Ivonne Magdalena Catharina Maria Rietjens
The development of reliable non-animal based testing strategies, such as in vitro bioassays, is the holy grail in current human safety testing of chemicals. However, the use of in vitro toxicity data in risk assessment is not straightforward. One of the main issues is that concentration-response curves from in vitro models need to be converted to in vivo dose-response curves. These dose-response curves are needed in toxicological risk assessment to obtain a point of departure to determine safe exposure levels for humans...
October 21, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27734789/regionalization-as-one-manifestation-of-the-pursuit-of-the-holy-grail
#18
Stephen Duckett
Regionalization has strengths and weaknesses. The balance of the two will vary over time, differing in different contexts and with different implementations. Alberta's implementation of a centralized structure had some strengths: economies of scale and expertise; opportunities for province-wide learning; internalization of geographic politics; and improved geographic equity. It also had weaknesses: diseconomies of scale, remoteness from communities and politicization. In any implementation of regionalization, policy makers should attempt to realize the benefits of alternative paths not travelled and minimise the weaknesses of the chosen structure...
2016: HealthcarePapers
https://www.readbyqxmd.com/read/27715079/interfacial-free-energy-as-the-key-to-the-pressure-induced-deceleration-of-ice-nucleation
#19
Jorge R Espinosa, Alberto Zaragoza, Pablo Rosales-Pelaez, Caridad Navarro, Chantal Valeriani, Carlos Vega, Eduardo Sanz
The avoidance of water freezing is the holy grail in the cryopreservation of biological samples, food, and organs. Fast cooling rates are used to beat ice nucleation and avoid cell damage. This strategy can be enhanced by applying high pressures to decrease the nucleation rate, but the physics behind this procedure has not been fully understood yet. We perform computer experiments to investigate ice nucleation at high pressures consisting in embedding ice seeds in supercooled water. We find that the slowing down of the nucleation rate is mainly due to an increase of the ice I-water interfacial free energy with pressure...
September 23, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27665861/the-next-generation-of-synthetic-biology-chassis-moving-synthetic-biology-from-the-laboratory-to-the-field
#20
Bryn L Adams
Escherichia coli (E. coli) has played a pivotal role in the development of genetics and molecular biology as scientific fields. It is therefore not surprising that synthetic biology (SB) was built upon E. coli and continues to dominate the field. However, scientific capabilities have advanced from simple gene mutations to the insertion of rationally designed, complex synthetic circuits and creation of entirely synthetic genomes. The point is rapidly approaching where E. coli is no longer an adequate host for the increasingly sophisticated genetic designs of SB...
December 16, 2016: ACS Synthetic Biology
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