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Holy Grail

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https://www.readbyqxmd.com/read/28645815/from-cellular-senescence-to-regeneration-a-quest-for-the-holy-grail-for-the-next-generation-of-surgeons
#1
EDITORIAL
Igor E Konstantinov, Xin Tao Ye, Tyson A Fricke
No abstract text is available yet for this article.
May 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28626365/emergence-of-cd43-expressing-hematopoietic-progenitors-from-human-induced-pluripotent-stem-cells
#2
Katharina U Kessel, Anika Bluemke, Hans R Schöler, Holm Zaehres, Peter Schlenke, Isabel Dorn
BACKGROUND: The ex vivo generation of human hematopoietic stem cells (HSCs) with long-term repopulating capacity and multi-lineage differentiation potential represents the holy grail of hematopoiesis research. In principle, human induced pluripotent stem cells (hiPSCs) provide the tool for both studying molecular mechanisms of hematopoietic development and the ex vivo production of 'true' HSCs for transplantation purposes and lineage-specific cells, e.g. red blood cells, for transfusion purposes...
June 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28621059/biomarkers-in-chronic-pelvic-pain-syndrome-did-we-find-the-holy-grail
#3
EDITORIAL
Thomas M Kessler
No abstract text is available yet for this article.
July 2017: BJU International
https://www.readbyqxmd.com/read/28591641/cardiac-stem-cells-for-myocardial-regeneration-promising-but-not-ready-for-prime-time
#4
REVIEW
Joshua Lader, Maxine Stachel, Lei Bu
Remarkable strides have been made in the treatment of ischemic heart disease in decades. As the initial loss of cardiomyocytes associated with myocardial infarction serves as an impetus for myocardial remodeling, the ability to replace these cells with healthy counterparts would represent an effective treatment for many forms of cardiovascular disease. The discovery of cardiac stem cells (that can differentiate into multiple lineages) highlighted the possibility for development of cell-based therapeutics to achieve this ultimate goal...
June 4, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28577716/articular-cartilage-the-search-for-the-holy-grail-of-treatment-and-restoration
#5
EDITORIAL
Eric C McCarty
No abstract text is available yet for this article.
July 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28570157/preserving-lung-function-the-holy-grail-in-managing-cystic-fibrosis
#6
Peter D Sly, Claire E Wainwright
No abstract text is available yet for this article.
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28566551/outcome-measures-in-the-idiopathic-inflammatory-myopathies-on-the-search-for-the-holy-grail
#7
EDITORIAL
Mazen M Dimachkie, Sabrina Paganoni
No abstract text is available yet for this article.
May 31, 2017: Neurology
https://www.readbyqxmd.com/read/28561695/biomarkers-for-checkpoint-inhibition
#8
Jeffrey S Weber
The identification of predictive biomarkers for the benefit of cancer immunotherapy is the holy grail of the burgeoning immunotherapy field. Recent work has shown that there are a core of concepts that establish the presence of an immune cell-infiltrate, an inflammatory signature of the tumor microenvironment, and the availability of target antigens defined by mutated neoantigens, as critical for the success of the checkpoint blockade. Genetic analyses have shown that resistance to PD-1 blockade, either innate or adaptive, may be due to existing or de novo mutations in signaling pathways critical for T-cell function in a modest proportion of cases...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28553203/autophagy-as-an-emerging-common-pathomechanism-in-inherited-peripheral-neuropathies
#9
REVIEW
Mansour Haidar, Vincent Timmerman
The inherited peripheral neuropathies (IPNs) comprise a growing list of genetically heterogeneous diseases. With mutations in more than 80 genes being reported to cause IPNs, a wide spectrum of functional consequences is expected to follow this genotypic diversity. Hence, the search for a common pathomechanism among the different phenotypes has become the holy grail of functional research into IPNs. During the last decade, studies on several affected genes have shown a direct and/or indirect correlation with autophagy...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28534784/incorporation-of-solvent-effect-into-multi-objective-evolutionary-algorithm-for-improved-protein-structure-prediction
#10
Shangce Gao, Jiujun Cheng, Yuki Todo, Mengchu Zhou
The problem of predicting the three-dimensional structure of a protein from its one-dimensional sequence has been called the "holy grail of molecular biology", and it has become an important part of structural genomics projects. Despite the rapid developments in computer technology and computational intelligence, it remains challenging and fascinating. In this paper, to solve it we propose a multi-objective evolutionary algorithm. We decompose the protein energy function Chemistry at HARvard Macromolecular Mechanics force fields into bond and non-bond energies as the first and second objectives...
May 17, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28530446/the-temptation-of-forbidden-fruit-and-the-pursuits-of-a-holy-grail
#11
Arthur I Eidelman
No abstract text is available yet for this article.
June 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28521905/harnessing-the-properties-of-dendritic-cells-in-the-pursuit-of-immunological-tolerance
#12
REVIEW
Christopher Horton, Kumaran Shanmugarajah, Paul J Fairchild
The acquisition of self-perpetuating, immunological tolerance specific for graft alloantigens has long been described as the "holy grail" of clinical transplantation. By removing the need for life-long immunosuppression following engraftment, the adverse consequences of immunosuppressive regimens, including chronic infections and malignancy, may be avoided. Furthermore, autoimmune diseases and allergy are, by definition, driven by aberrant immunological responses to ordinarily innocuous antigens. The re-establishment of permanent tolerance towards instigating antigens may, therefore, provide a cure to these common diseases...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28512845/work-retirement-and-muscle-strength-loss-in-old-age
#13
Marco Bertoni, Stefania Maggi, Guglielmo Weber
Reduced muscle strength is an accurate predictor of functional limitations, disability, and mortality. Hence, understanding which socio-economic factors contribute to preserve muscle strength in old age is central to the design of social policies that help reducing these health risks. Using data on handgrip strength collected by the Survey of Health, Ageing and Retirement in Europe for the population of Europeans aged 50+ and the exogenous variation in pension eligibility age across countries over time, we estimate that the retirement transition has a short-term positive causal effect on muscle strength...
May 17, 2017: Health Economics
https://www.readbyqxmd.com/read/28495653/in-search-of-the-holy-grail-in-the-channelopathy-field-proving-pathogenicity-of-long-qt-syndrome-associated-variants
#14
EDITORIAL
Arthur A M Wilde, Christopher Semsarian
No abstract text is available yet for this article.
May 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28488907/prediction-the-modern-day-sports-science-medicine-quest-for-the-holy-grail
#15
Alan McCall, Maurizio Fanchini, Aaron J Coutts
In high performance sport, science and medicine practitioners employ a variety of physical and psychological tests, training/match monitoring and injury screening tools for a variety of reasons; mainly to predict performance, identify talented individuals and flag when an injury will occur. The ability to 'predict' outcomes such as performance, talent or injury is arguably the sports science/medicine modern day equivalent of the 'Quest for the Holy Grail'. The purpose of this invited commentary is to 1) highlight the common misinterpretation of studies investigating association to those actually analysing prediction and 2) provide practitioners with simple recommendations to quickly distinguish between methods pertaining to association and those of prediction...
May 10, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28483215/searching-for-the-holy-grail-can-there-ever-be-such-a-thing-as-a-grand-unified-theory-of-sports-performance
#16
A M Williams, P Ward
No abstract text is available yet for this article.
May 5, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28465001/neuroprotection-in-the-treatment-of-acute-ischemic-stroke
#17
REVIEW
Rajan A G Patel, Paul W McMullen
Neuroprotection remains one of the holy grails of acute ischemic stroke therapy. The ability to protect the ischemic brain from injury until reperfusion and then to protect the brain from reperfusion injury could theoretically improve freedom from disability among stroke survivors. This manuscript reviews the molecular and cellular pathophysiology of stroke and summarizes pharmacologic and other therapies that showed promise in pre-clinical testing as neuroprotection agents. However to date, no compelling efficacy data have been published regarding any pharmacologic or other therapies...
April 30, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28430178/endothelial-keratoplasty-is-descemet-membrane-endothelial-keratoplasty-the-holy-grail-of-lamellar-surgery-no
#18
M Tsatsos, V S Liarakos, C MacGregor, I Athanasiadis, E T Detorakis, M M Moschos, P Hossain, D F Anderson
No abstract text is available yet for this article.
April 21, 2017: Eye
https://www.readbyqxmd.com/read/28401962/diamond-like-carbon-coating-under-oleic-acid-lubrication-evidence-for-graphene-oxide-formation-in-superlow-friction
#19
Maria Isabel De Barros Bouchet, Jean Michel Martin, José Avila, Makoto Kano, Kentaro Yoshida, Takeshi Tsuruda, Shandan Bai, Yuji Higuchi, Nobuki Ozawa, Momoji Kubo, Maria C Asensio
The achievement of the superlubricity regime, with a friction coefficient below 0.01, is the Holy Grail of many tribological applications, with the potential to have a remarkable impact on economic and environmental issues. Based on a combined high-resolution photoemission and soft X-ray absorption study, we report that superlubricity can be realized for engineering applications in bearing steel coated with ultra-smooth tetrahedral amorphous carbon (ta-C) under oleic acid lubrication. The results show that tribochemical reactions promoted by the oil lubrication generate strong structural changes in the carbon hybridization of the ta-C hydrogen-free carbon, with initially high sp(3) content...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401258/tumor-associated-myeloid-cells-as-guiding-forces-of-cancer-cell-stemness
#20
REVIEW
Antonio Sica, Chiara Porta, Alberto Amadori, Anna Pastò
Due to their ability to differentiate into various cell types and to support tissue regeneration, stem cells simultaneously became the holy grail of regenerative medicine and the evil obstacle in cancer therapy. Several studies have investigated niche-related conditions that favor stemness properties and increasingly emphasized their association with an inflammatory environment. Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) are major orchestrators of cancer-related inflammation, able to dynamically express different polarized inflammatory programs that promote tumor outgrowth, including tumor angiogenesis, immunosuppression, tissue remodeling and metastasis formation...
April 11, 2017: Cancer Immunology, Immunotherapy: CII
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