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Holy Grail

Kapil S Agrawal, Mansi Pabari, Raghav Shrotriya
"A smile is happiness you'll find right under your nose"- Tom Wilson. This quote holds true just for patients, not for surgeons. The correction of the nose always poses a challenge to the cosmetic surgeon. Deformities of the external and internal nose may be congenital or acquired and may be secondary to soft tissue and/or osseo-cartilaginous abnormalities, leading to aesthetic and/or functional consequences. Alar flare poses a common problem, sometimes alone and sometimes in conjunction with other external deformities...
November 2016: Archives of Plastic Surgery
Ivan Stankovic
No abstract text is available yet for this article.
November 2016: Anatolian Journal of Cardiology
Xavier Rossello, Derek M Yellon
The EMPA-REG OUTCOME and the LEADER trials have revealed a new era in the management of type 2 diabetes. The SGLT2 inhibitor empagliflozin demonstrated a lower rate of the primary composite outcome of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke compared to placebo. Liraglutide, a GLP-1 analogue, succeeded to demonstrate reduction on a composite outcome including first occurrence of cardiovascular death, nonfatal myocardial infarction or non-fatal stroke. These two medications act through different mechanisms and has consequently shown different patterns of cardiovascular benefit...
November 12, 2016: International Journal of Cardiology
Marco Cardinale, Matthew C Varley
The need to quantify aspects of training in order to improve training prescription has been the holy grail of sport scientists and coaches for many years. Recently, there has been an increase in scientific interest, possibly due to technological advancements and better equipment to quantify training activities. Over the last few years there has been an increase in the number of studies assessing training load in various athletic cohorts with a bias towards subjective reports and/or quantifications of external load...
November 11, 2016: International Journal of Sports Physiology and Performance
Jin Li, Zilong Liu
Imaging integrated with compression is considered the holy grail of microsatellite photography because it improves the degree of integration of the camera system, removing the compression system, high capacity storage system, and high-speed image transmission system, which consume lots of resources of the satellite platform. In this paper, we propose an efficient compressed imaging method for remote sensing photography. We consider wavelet coefficients as pixels of a block-wise megapixel sensor (BMPS). We integrate the saliency information stage into the BMPS to perform compressed sampling (CS) in order to further improve imaging performance...
October 1, 2016: Applied Optics
Jorge Fontes, Brice Semmens, Jennifer E Caselle, Ricardo S Santos, Shree R Prakya
Predicting recruitment fluctuations of fish populations remains the Holy Grail of fisheries science. While previous work has linked recruitment of reef fish to environmental variables including temperature, the demonstration of a robust relationship with productivity remains elusive. Despite decades of research, empirical evidence to support this critical link remains limited. Here we identify a consistent and strong relationship between recruitment of a temperate wrasse Coris julis, from temperate reefs in the mid-Atlantic region, with Chlorophyll, over contrasting scales, across multiple years...
2016: PloS One
Z Wang, L A Campos, V Muñoz
Watching the conformational wanderings of protein molecules during their search for their native structure is a holy grail for protein folding experimentalists. Such capability is essential to provide reality checks to the complex mechanistic heterogeneity that theory and molecular simulations predict. Single-molecule fluorescence resonance energy transfer (SM-FRET) is an attractive technique to meet that end, but its time resolution was insufficient for the microsecond motions of folding proteins. The temporal resolution of SM-FRET pivots on how quickly photons emitted by an individual molecule can be collected in sufficient numbers as to minimize statistical shot noise...
2016: Methods in Enzymology
Jochem Louisse, Karsten Beekmann, Ivonne Magdalena Catharina Maria Rietjens
The development of reliable non-animal based testing strategies, such as in vitro bioassays, is the holy grail in current human safety testing of chemicals. However, the use of in vitro toxicity data in risk assessment is not straightforward. One of the main issues is that concentration-response curves from in vitro models need to be converted to in vivo dose-response curves. These dose-response curves are needed in toxicological risk assessment to obtain a point of departure to determine safe exposure levels for humans...
October 21, 2016: Chemical Research in Toxicology
Stephen Duckett
Regionalization has strengths and weaknesses. The balance of the two will vary over time, differing in different contexts and with different implementations. Alberta's implementation of a centralized structure had some strengths: economies of scale and expertise; opportunities for province-wide learning; internalization of geographic politics; and improved geographic equity. It also had weaknesses: diseconomies of scale, remoteness from communities and politicization. In any implementation of regionalization, policy makers should attempt to realize the benefits of alternative paths not travelled and minimise the weaknesses of the chosen structure...
2016: HealthcarePapers
Jorge R Espinosa, Alberto Zaragoza, Pablo Rosales-Pelaez, Caridad Navarro, Chantal Valeriani, Carlos Vega, Eduardo Sanz
The avoidance of water freezing is the holy grail in the cryopreservation of biological samples, food, and organs. Fast cooling rates are used to beat ice nucleation and avoid cell damage. This strategy can be enhanced by applying high pressures to decrease the nucleation rate, but the physics behind this procedure has not been fully understood yet. We perform computer experiments to investigate ice nucleation at high pressures consisting in embedding ice seeds in supercooled water. We find that the slowing down of the nucleation rate is mainly due to an increase of the ice I-water interfacial free energy with pressure...
September 23, 2016: Physical Review Letters
Bryn L Adams
Escherichia coli (E. coli) has played a pivotal role in the development of genetics and molecular biology as scientific fields. It is therefore not surprising that synthetic biology (SB) was built upon E. coli and continues to dominate the field. However, scientific capabilities have advanced from simple gene mutations to the insertion of rationally designed, complex synthetic circuits and creation of entirely synthetic genomes. The point is rapidly approaching where E. coli is no longer an adequate host for the increasingly sophisticated genetic designs of SB...
September 26, 2016: ACS Synthetic Biology
Faisal F Syed, Hakan Oral
No abstract text is available yet for this article.
August 3, 2016: Trends in Cardiovascular Medicine
Hang Ren, Jianfeng Wu, Alessandro Colletta, Mark E Meyerhoff, Chuanwu Xi
Fast eradication of mature biofilms is the 'holy grail' in the clinical management of device-related infections. Endogenous nitric oxide (NO) produced by macrophages plays an important role in host defense against intracellular pathogens, and NO is a promising agent in preventing biofilms formation in vitro. However, the rate of delivery of NO by various NO donors (e.g., diazeniumdiolates, S-nitrosothiols, etc.) is difficult to control, which hinders fundamental studies aimed at understanding the role of NO in biofilm control...
2016: Frontiers in Microbiology
Jun-Xu Li
No abstract text is available yet for this article.
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
Stephen R Williams, Svetlana Lorenzano
No abstract text is available yet for this article.
September 20, 2016: Neurology
Trilok Singh, Jai Singh, Tsutomu Miyasaka
Organic-inorganic hybrid perovskite light absorbers have recently emerged as a "holy grail" for next generation thin-film photovoltaics with excellent optoelectronics properties and low fabrication cost. In a very short span of time, we have witnessed a pronounced and unexpected progress in organic- inorganic perovskite solar cells (PSCs) with a vertical rise in power conversion efficiency from 3.8 to 22.1 %. In this manuscript we focus specifically on the recent development of metal oxide-based electron-transporting layer (ETL) modification for high performing PSCs and their stability...
September 22, 2016: ChemSusChem
Arschang Valipour
No abstract text is available yet for this article.
October 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Dan Benjamini, Peter J Basser
Measuring multidimensional (e.g., 2D) relaxation spectra in NMR and MRI clinical applications is a holy grail of the porous media and biomedical MR communities. The main bottleneck is the inversion of Fredholm integrals of the first kind, an ill-conditioned problem requiring large amounts of data to stabilize a solution. We suggest a novel experimental design and processing framework to accelerate and improve the reconstruction of such 2D spectra that uses a priori information from the 1D projections of spectra, or marginal distributions...
October 2016: Journal of Magnetic Resonance
Mathew John, Ambika Gopalakrishnan Unnikrishnan, Sanjay Kalra, Tiny Nair
Since the time questions arose on cardiovascular safety of Rosiglitazone, FDA has suggested guidelines on conduct of studies on anti-diabetic drugs so as to prove that the cardiovascular risk is acceptable. Based on the cardiovascular risks of pre-approval clinical trials, guidelines have been made to conduct cardiovascular safety outcome trials (CVSOTs) prior to the drug approval or after the drug has been approved. Unlike the trials comparing the efficacy of antidiabetic agents, the CVSOTs examine the cardiovascular safety of a drug in comparison to standard of care...
July 2016: Indian Heart Journal
Kevin Liou, Nigel Jepson
No abstract text is available yet for this article.
July 2016: Journal of Thoracic Disease
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