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Holy Grail

Chadrick E Denlinger
No abstract text is available yet for this article.
May 18, 2018: Seminars in Thoracic and Cardiovascular Surgery
S Fair, P Lonergan
The ability to predict the fertility of bulls before semen is released into the field has been a long-term objective of the animal breeding industry. However, the recent shift in the dairy industry towards the intensive use of young genomically selected bulls has increased its urgency. Such bulls, which are often in the highest demand, are frequently only used intensively for one season and consequently there is limited time to track their field fertility. A more pressing issue is that they produce fewer sperm per ejaculate than mature bulls and therefore there is a need to reduce the sperm number per straw to the minimum required without a concomitant reduction in fertility...
May 21, 2018: Animal: An International Journal of Animal Bioscience
Tanya L Applegate, Emmanuel Fajardo, Jilian A Sacks
The world has embraced the call for global elimination of hepatitis C virus by 2030. The unprecedented speed of therapeutic development and increased access to direct-acting antivirals has made elimination a possibility. We must screen hundreds of millions of people to diagnose and treat those currently infected. Global access to hepatitis C virus diagnostics will be a keystone to success. Key challenges must be overcome and systems optimized to ensure widespread access to existing diagnostics. Although promising technologies may soon transform the landscape, innovative strategies are needed to stimulate investment and accelerate the development of point-of-care hepatitis C virus diagnostics...
June 2018: Infectious Disease Clinics of North America
Kenneth A Ellenbogen, Santosh K Padala
No abstract text is available yet for this article.
May 22, 2018: Journal of the American College of Cardiology
Craig F Morris
Noodles are a leading food in the world, and color is a key determinant of consumer acceptance. In this review the two prominent forms of wheat noodles are considered, white salted and alkaline. Many of the preparation and evaluation strategies are the same for both, with prominence placed on 'brightness' (L*) or a lack of discoloration (ΔL*), and the absence of 'specks'. All raw noodles darken over time. Increasing protein content of flours almost always translates into darker noodles. Greater discoloration is also associated with higher flour extraction rates, higher ash contents and higher starch damage...
May 16, 2018: Journal of the Science of Food and Agriculture
Suresh K Vasa, Petra Rovó, Rasmus Linser
Solid-state nuclear magnetic resonance (ssNMR) is a spectroscopic technique that is used for characterization of molecular properties in the solid phase at atomic resolution. In particular, using the approach of magic-angle spinning (MAS), ssNMR has seen widespread applications for topics ranging from material sciences to catalysis, metabolomics, and structural biology, where both isotropic and anisotropic parameters can be exploited for a detailed assessment of molecular properties. High-resolution detection of protons long represented the holy grail of the field...
May 15, 2018: Accounts of Chemical Research
Jianwen Hou, Margarita Vázquez-González, Michael Fadeev, Xia Liu, Ronit Lavi, Itamar Willner
Catalyzed oxygen insertion into C-H bonds represents a continuous challenge in chemistry. Particularly, driving this process at ambient temperatures and aqueous media represent a "holy grail" in catalysis. We report on the catalyzed cascade transformations of L-tyrosine or L-phenylalanine to dopachrome in the presence of L-ascorbic acid/H2 O2 oxidizing mixture and CuFe-Prussian Blue-like nanoparticles, Fe3 O4 nanoparticles or Au nanoparticles as catalysts. The process involves the primary transformation of L-tyrosine to L-DOPA that is further oxidized to dopachrome...
May 10, 2018: Nano Letters
Maciej Krzeszewski, Eli M Espinoza, Ctirad Červinka, James B Derr, John A Clark, Dan Borchardt, Gregory J O Beran, Daniel T Gryko, Valentine I Vullev
Electric dipoles are everywhere, and the importance of understanding how they affect chemical, physical and biological processes cannot be overstated. Electron transfer (ET) is essential for sustaining life and for making energy conversion possible. Molecular dipoles present important, but underutilized, paradigms for guiding ET processes. While dipoles generate fields of Gigavolts per meter in their vicinity, reported differences between rates of ET along vs. against dipoles are often small or undetectable...
May 9, 2018: Angewandte Chemie
Minseung Kim, Ilias Tagkopoulos
Translating data to knowledge and actionable insights is the Holy Grail for many scientific fields, including biology. The unprecedented massive and heterogeneous data have created as many challenges to store, process and analyze as the opportunities and promises they hold. Here, we provide an overview of these opportunities and challenges in multi-omics predictive analytics.
February 12, 2018: Molecular omics
Brian E Louie
No abstract text is available yet for this article.
April 5, 2018: Journal of Thoracic and Cardiovascular Surgery
Paul Conroy, Christina Sotiropoulou Drosopoulou, Gina F Humphreys, Ajay D Halai, Matthew A Lambon Ralph
One-third of stroke survivors experience deficits in word retrieval as a core characteristic of their aphasia, which is frustrating, socially limiting and disabling for their professional and everyday lives. The, as yet, undiscovered 'holy grail' of clinical practice is to establish a treatment that not only improves item naming, but also generalizes to patients' connected speech. Speech production in healthy participants is a remarkable feat of cognitive processing being both rapid (at least 120 words per minute) and accurate (∼one error per 1000 words)...
April 17, 2018: Brain: a Journal of Neurology
Katherine L Williams, Bingjie Wang, Dana Arenz, James A Williams, Adam S Dingens, Valerie Cortez, Cassandra A Simonich, Stephanie Rainwater, Dara A Lehman, Kelly K Lee, Julie Overbaugh
Eliciting broad and potent HIV-specific neutralizing antibody responses represents the holy grail of HIV vaccine efforts. Data from singly infected individuals with broad and potent plasma neutralizing activity targeting one epitope have guided our understanding of how these responses develop. However, far less is known about responses developed by superinfected individuals who acquire two distinct HIV strains. Here, we isolated HIV-specific mAbs from a superinfected individual with a broad plasma response...
April 17, 2018: Cell Reports
Ourania Preventza, Peter Chen
No abstract text is available yet for this article.
March 28, 2018: Journal of Thoracic and Cardiovascular Surgery
Run Hu, Shuling Zhou, Ying Li, Dang-Yuan Lei, Xiaobing Luo, Cheng-Wei Qiu
"Fata Morgana" or "Mirage" phenomena have long been captivated as optical illusions, which actually relies on gradient-density air or vapor. Man-made optical illusions have witnessed significant progress by resorting to artificially structured metamaterials. Nevertheless, two long-standing challenges remain formidable: first, exotic parameters (negative or less than unity) become inevitable; second, the signature of original object is altered to that of a virtual counterpart. It is thus not able to address the holy grail of illusion per se, since a single virtual object still exposes the location...
April 17, 2018: Advanced Materials
Boglarka Donczo, Andras Guttman
More than a century ago in 1893, a revolutionary idea about fixing biological tissue specimens was introduced by Ferdinand Blum, a German physician. Since then, a plethora of fixation methods have been investigated and used. Formalin fixation with paraffin embedment became the most widely used types of fixation and preservation method, due to its proper architectural conservation of tissue structures and cellular shape. The huge collection of formalin-fixed, paraffin-embedded (FFPE) sample archives worldwide holds a large amount of unearthed information about diseases that could be the Holy Grail in contemporary biomarker research utilizing analytical omics based molecular diagnostics...
April 2, 2018: Journal of Pharmaceutical and Biomedical Analysis
Kapil S Agrawal, Anup Vidyadhar Sarda, Raghav Shrotriya, Manoj Bachhav, Vinita Puri, Gita Nataraj
Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. In this study, we have evaluated the use of acetic acid for topical application in the treatment of infected wounds...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Jeffrey H Kordower, Robert E Burke
Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regeneration and trophic factor delivery for the nigrostriatal system as 2 such approaches that historically have initiated much excitement. However, we conclude this discussion with the following question: has science passed these approaches by? © 2018 International Parkinson and Movement Disorder Society...
March 30, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Xi Ke, Yifeng Cheng, Jun Liu, Liying Liu, Naiguang Wang, Jianping Liu, Chunyi Zhi, Zhicong Shi, Zaiping Guo
Rechargeable lithium metal anodes (LMAs) with long cycling life have been regarded as the "Holy Grail" for high-energy-density lithium metal secondary batteries. The skeleton plays an important role in determining the performance of LMAs. Commercially available copper foam (CF) is not normally regarded as a suitable skeleton for stable lithium storage owing to their relatively inappropriate large pore size and relatively low specific surface area. Herein, for the first time, we revisit CF and address these issues by rationally designing a highly porous copper (HPC) architecture grown on CF substrate (HPC/CF) as a 3D hierarchically bicontinuous porous skeleton through a novel approach combining self-assembly of polystyrene microspheres, electrodeposition of copper, and a thermal annealing treatment...
March 30, 2018: ACS Applied Materials & Interfaces
Shuru Chen, Jianming Zheng, Donghai Mei, Kee Sung Han, Mark H Engelhard, Wengao Zhao, Wu Xu, Jun Liu, Ji-Guang Zhang
Rechargeable lithium-metal batteries (LMBs) are regarded as the "holy grail" of energy-storage systems, but the electrolytes that are highly stable with both a lithium-metal anode and high-voltage cathodes still remain a great challenge. Here a novel "localized high-concentration electrolyte" (HCE; 1.2 m lithium bis(fluorosulfonyl)imide in a mixture of dimethyl carbonate/bis(2,2,2-trifluoroethyl) ether (1:2 by mol)) is reported that enables dendrite-free cycling of lithium-metal anodes with high Coulombic efficiency (99...
March 25, 2018: Advanced Materials
Hope Cottrill, Stephanie Cason, Scott Caroen, Bryan Oronsky, Elvis Donaldson
This case report describes the clinical course of a heavily pretreated patient enrolled on the Phase II QUADRUPLE THREAT clinical trial (NCT02489903) with recurrent metastatic epithelial ovarian cancer that was previously treated with a platinum doublet and that benefited from another reintroduction of a platinum doublet after a brief priming period with RRx-001. Platinum-taxane combination is the initial treatment of choice in ovarian cancer and the "go-to regimen" for patients with recurrent, platinum-sensitive disease...
January 2018: Journal of Investigative Medicine High Impact Case Reports
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