Ian Sorrell, Rebecca J Shipley, Sophie Regan, Iain Gardner, Michael P Storm, Marianne Ellis, John Ward, Dominic Williams, Pratibha Mistry, José Domingo Salazar, Andrew Scott, Steven Webb
A mathematical model has been developed to assist with the development of a hollow fibre bioreactor (HFB) for hepatotoxicity testing of xenobiotics; specifically, to inform the HFB operating set-up, interpret data from HFB outputs and aid in optimizing HFB design to mimic certain hepatic physiological conditions. Additionally, the mathematical model has been used to identify the key HFB and compound parameters that will affect xenobiotic clearance. The analysis of this model has produced novel results that allow the operating set-up to be calculated, and predictions of compound clearance to be generated...
May 14, 2019: Journal of Theoretical Biology