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https://www.readbyqxmd.com/read/29331635/sotatercept-with-long-term-extension-for-the-treatment-of-anaemia-in-patients-with-lower-risk-myelodysplastic-syndromes-a-phase-2-dose-ranging-trial
#1
Rami Komrokji, Guillermo Garcia-Manero, Lionel Ades, Thomas Prebet, David P Steensma, Joseph G Jurcic, Mikkael A Sekeres, Jesus Berdeja, Michael R Savona, Odile Beyne-Rauzy, Aspasia Stamatoullas, Amy E DeZern, Jacques Delaunay, Gautam Borthakur, Robert Rifkin, Thomas E Boyd, Abderrhamane Laadem, Bond Vo, Jennie Zhang, Marie Puccio-Pick, Kenneth M Attie, Pierre Fenaux, Alan F List
BACKGROUND: Myelodysplastic syndromes are characterised by ineffective erythropoiesis leading to anaemia. Sotatercept (ACE-011) is a novel activin receptor type IIA fusion protein that acts as a ligand trap to neutralise negative regulators of late-stage erythropoiesis. The aim of the study was to establish a safe and effective dose of sotatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes. METHODS: This open-label, multicentre, dose-ranging, phase 2 trial took place at 11 treatment centres in the USA and France...
January 10, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29325512/an-industry-update-the-latest-developments-in-therapeutic-delivery
#2
Oliver C Steinbach
The present industry update covers the period 1 October-31 October 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. While the corporate news in October was traditionally dominated by the announcement of the third quarter results, with most of them showing market and revenue growth but also an increasing number of initial public offerings after years of slower financial development, we also saw trends continuing toward an increasing number of convergences of drugs with nanotechnology, devices and 21st century information technology...
February 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29317065/nature-exposure-sufficiency-and-insufficiency-the-benefits-of-environmental-preservation
#3
John R Reddon, Salvatore B Durante
Increasing industrialization, urbanization, and a failure of many world leaders to appreciate the consequences of climate change are deleteriously impacting quality of life as well as diminishing the prospects for long term survival. Economic competitiveness and corporate profitability often pre-empt environmental concerns. The calving of an iceberg in Antarctica and the hurricane activity in the Caribbean during 2017 are unfortunate illustrations of the continuing escalation of environmental issues. We provide historical and current evidence for the importance of Nature Exposure (NE) and introduce the continuum Nature Exposure Sufficiency (NES) and Insufficiency (NEI)...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29314650/validation-of-reflex-testing-rules-and-establishment-of-a-new-workflow-for-body-fluid-cell-analysis-using-a-sysmex-xn-550-automatic-hematology-analyzer
#4
Y-U Cho, E You, S Jang, C-J Park
INTRODUCTION: We developed and validated reflex testing rules for the microscopic examination (ME) of body fluids (BFs) on the Sysmex XN-550 (Sysmex Corporation) instrument. METHODS: We assessed the detection limits, precision, linearity, and carryover. To develop the reflex testing rules (derivation arm), we tested 515 samples and then validated the rules using another 507 samples (validation arm). RESULTS: All analytical performances were acceptable, and the carryover was negligible...
January 4, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29313034/the-wyss-institute-a-new-model-for-medical-technology-innovation-and-translation-across-the-academic-industrial-interface
#5
REVIEW
Mary Tolikas, Ayis Antoniou, Donald E Ingber
The Wyss Institute for Biologically Inspired Engineering at Harvard University was formed based on the recognition that breakthrough discoveries cannot change the world if they never leave the laboratory. The Institute's mission is to discover the biological principles that Nature uses to build living things, and to harness these insights to create biologically inspired engineering innovations to advance human health and create a more sustainable world. Since its launch in 2009, the Institute has developed a new model for innovation, collaboration, and technology translation within academia, breaking "silos" to enable collaborations that cross institutional and disciplinary barriers...
September 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29299902/role-of-penile-prosthesis-in-priapism-a-review
#6
REVIEW
Amit G Reddy, Laith M Alzweri, Andrew T Gabrielson, Gabriel Leinwand, Wayne J G Hellstrom
Ischemic priapism is a urological emergency that has been associated with long-standing and irreversible adverse effects on erectile function. Studies have demonstrated a linear relationship between the duration of critically ischemic episodes and the subsequent development of corporal fibrosis and irreversible erectile function loss. Placement of a penile prosthesis is a well-established therapeutic option for the management of erectile dysfunction secondary to ischemic priapism, and will be the focus of this review...
January 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29294970/evaluation-of-parenting-interventions-to-prevent-violence-against-children-in-colombia-a-randomized-controlled-trial
#7
Ane-Marthe Solheim Skar, Lorraine Sherr, Ana Macedo, Stephen von Tetzchner, Knut Inge Fostervold
The effects of the International Child Development Programme (ICDP) and the specific addition of a violence prevention module were observed in a preidentified population in Colombia where children are experiencing high levels of violence. Participants were 176 parents of 3- to 4-year-olds attending child centers who were randomly allocated to one of three conditions: organized Community Activities at child centers and ICDP (CA + ICDP), CA, ICDP, and a preventive Violence Curriculum (CA + ICDP + VC), or a comparison group with only CA...
November 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294933/the-cycle-of-violence-examining-attitudes-toward-and-experiences-of-corporal-punishment-in-a-representative-german-sample
#8
Andreas Witt, Jörg M Fegert, Klaus P Rodens, Elmar Brähler, Claudia Lührs Da Silva, Paul L Plener
The use of corporal punishment (CP) is controversial despite the negative consequences of its use that have been documented. Consequences include the use of CP by those who experienced CP themselves, described in the theory of the cycle of violence. There are little data on the cycle of violence, especially on those who break it and in representative samples. This study examines the cycle of violence in a representative sample by analyzing experiences of and attitudes toward CP. Attitudes toward, and own experiences of, CP by their parents were assessed in a sample of 2,519 individuals (female 54...
September 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29290171/health-care-costs-and-thromboembolic-events-in-hydroxyurea-treated-patients-with-polycythemia-vera
#9
Shreekant V Parasuraman, Nianwen Shi, Dilan C Paranagama, Machaon Bonafede
BACKGROUND: Patients with polycythemia vera (PV) are at increased risk of thromboembolic events (TEs), which are key contributors to reduced overall survival compared with the age- and sex-matched general population. In addition to aspirin and phlebotomy to maintain hematocrit level < 45%, many patients receive cytoreduction with hydroxyurea (HU), which is associated with improved survival and may reduce the risk of cardiovascular events and TEs. However, 1 in 4 patients become resistant to or intolerant of HU...
January 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29286884/antigenotoxicity-properties-of-copaifera-multijuga-oleoresin-and-its-chemical-marker-the-diterpene-copalic-acid
#10
Jacqueline Morais Alves, Luís Fernando Leandro, Juliana Marques Senedese, Pâmela Tinti de Castro, Daiane Eleutério Pereira, Flávia Aparecida Resende, Débora Leite Campos, Jonas Joaquim Mangabeira da Silva, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares
In view of the biological activities and growing therapeutic interest in oleoresin obtained from Copaifera multijuga, this study aimed to determine the genotoxic and antigenotoxic potential of this oleoresin (CMO) and its chemical marker, diterpene (-)-copalic acid (CA). The micronucleus (MN) assay in V79 cell cultures and the Ames test were used for in vitro analyses, as well as MN and comet assays in Swiss mice for in vivo analyses. The in vitro genotoxicity/mutagenicity results showed that either CMO (30, 60, or 120 µg/ml-MN assay; 0...
December 29, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29273785/construction-of-engineered-corpus-cavernosum-with-primary-mesenchymal-stem-cells-in-vitro
#11
Xiaoshuai Xie, Xiaohang Du, Kailin Li, Yuan Chen, Yong Guan, Xiaofei Zhao, Guangzhu Niu, Yun Luan, Denglu Zhang, Chao Sun, Guanghui Cheng, Jue Wang, Qian Xin, Aibing Xue, Peng Wang, Feng Kong, Xiaoli Liu, Hongwei Wang, Yuqiang Liu, Chuan Tian, Mingzhen Yuan, Shuangde Liu, Shengtian Zhao
Various methods have been used to reconstruct the penis. The objective of this study was to investigate the feasibility of constructing engineered corpus cavernosum with primary mesenchymal stem cells (MSCs) in a rabbit model in vitro. Acellular corporal matrices (ACMs) were obtained from adult rabbit penile tissues through an established decellularization procedure. MSCs were separated, purified, and then seeded on ACMs to construct engineered corpus cavernosum. The seeded ACMs were subsequently cultured in an incubator for 14 days...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29261125/rheological-characterization-as-an-alternative-method-to-indentation-for-determining-the-setting-time-of-restorative-and-endodontic-cements
#12
William N Ha, Timothy M Nicholson, Bill Kahler, Laurence J Walsh
This study explored an alternative approach using rheology to assess setting time. The following cements were tested: ProRoot® MTA (Dentsply, Tulsa, OK, USA), Biodentine® (Septodont, Saint Maur des Fosses, France), Fuji VII®, FujiVII® EP, and Fuji IX® (from GC Corporation, Tokyo, Japan), RealSeal SE™ Sealer (SybronEndo, Amersfoort, The Netherlands), AH 26® and AH Plus (both from Dentsply DeTrey, Konstanz, Germany). Freshly mixed cements were placed into a strain-controlled rheometer (1 rad·s-1 with an applied strain of 0...
December 20, 2017: Materials
https://www.readbyqxmd.com/read/29233698/ex-corpore-linguae-a-cohort-analysis-after-a-unique-surgical-technique-in-oral-cancer-resection
#13
Jan-Falco Wilbrand, Daniel Schmermund, Michael Knitschke, Philipp Streckbein, Christopher Kähling, Heiko Kerkmann, Heidrun Schaaf, Hans-Peter Howaldt, Sebastian Böttger
OBJECTIVE: Resection of posteriorly located oral squamous cell carcinomas (OSCCs) remains challenging for head and neck surgeons. However, several surgical techniques, such as lip and mandibular splitting, as well as submental "visor drop-down" of intraoral soft tissues, have been proposed for this purpose. Merrick et al. suggested that a pedicled genial drop-down surgical approach should be used to resect dorsally located OSCCs. Our study investigated patient outcomes following this surgical procedure, as no previous study has analyzed long-term follow-up data...
November 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29231873/does-practicing-csr-makes-consumers-like-your-shop-more-consumer-retailer-love-mediates-csr-and-behavioral-intentions
#14
Ching-Wei Ho
This research paper was designed to examine the influence of corporate social responsibility (CSR) associations and environmental concerns on consumer-retailer love and attitude toward the retailer, as well as the subsequent effects on consumer behavioral intentions regarding the retailer, such as repeat patronage intention and willingness to pay a premium price for products offered by the retailer. In this study, a questionnaire survey was conducted on consumers for the purpose of investigating five proposed hypotheses...
December 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29229857/effect-of-oil-palm-sustainability-certification-on-deforestation-and-fire-in-indonesia
#15
Kimberly M Carlson, Robert Heilmayr, Holly K Gibbs, Praveen Noojipady, David N Burns, Douglas C Morton, Nathalie F Walker, Gary D Paoli, Claire Kremen
Many major corporations and countries have made commitments to purchase or produce only "sustainable" palm oil, a commodity responsible for substantial tropical forest loss. Sustainability certification is the tool most used to fulfill these procurement policies, and around 20% of global palm oil production was certified by the Roundtable on Sustainable Palm Oil (RSPO) in 2017. However, the effect of certification on deforestation in oil palm plantations remains unclear. Here, we use a comprehensive dataset of RSPO-certified and noncertified oil palm plantations (∼188,000 km2) in Indonesia, the leading producer of palm oil, as well as annual remotely sensed metrics of tree cover loss and fire occurrence, to evaluate the impact of certification on deforestation and fire from 2001 to 2015...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29226349/what-do-we-know-about-coaching-in-medical-education-a-literature-review
#16
REVIEW
Ben Lovell
CONTEXT: Coaching has been employed successfully in the competitive sports, professional music, and business and corporate worlds. It is now emerging as a training modality in medical education. OBJECTIVES: This paper reviews the current evidence on coaching strategies for doctors and medical students. METHODS: An applied literature search was conducted in PubMed, MEDLINE and Web of Science. Predetermined definitions of coaching interventions and their evaluations were used to narrow 993 papers down to 21, which were included in the final review...
December 11, 2017: Medical Education
https://www.readbyqxmd.com/read/29223888/neighborhood-crime-undermines-parenting-violence-in-the-vicinity-of-households-as-a-predictor-of-aggressive-discipline
#17
Jorge Cuartas
Child discipline is a central component of parent-child interactions. Evidence suggests corporal discipline impairs children's physical, cognitive, and socioemotional development and compromises their future chances, especially since it is more frequently used against at-risk children. Using geocoded data for 1209 children under the age of five and their mothers, this study analyses the relation between the occurrence of crimes in close proximity to households in four major urban municipalities of Colombia and a particularly violent corporal discipline practice: hitting children with objects...
December 7, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29218418/agricultural-water-policy-reforms-in-china-a-representative-look-at-zhangye-city-gansu-province-china
#18
Tomohiro Akiyama, Ali Kharrazi, Jia Li, Ram Avtar
Water resources are essential for agricultural production in the grain-producing region of China, and water shortage could significantly affect the production and international trade of agricultural products. China is placing effort in new policies to effectively respond to changes in water resources due to changes in land use/land cover as well as climatic variations. This research investigates the changes in land, water, and the awareness of farmer vis-à-vis the implementation of water-saving policies in Zhangye City, an experimental site for pilot programs of water resources management in China...
December 7, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29217100/childhood-corporal-punishment-and-future-perpetration-of-physical-dating-violence
#19
Jeff R Temple, Hye Jeong Choi, Tyson Reuter, David Wolfe, Catherine A Taylor, Sheri Madigan, Lauren E Scott
OBJECTIVE: To test whether experiencing childhood corporal punishment is linked to later perpetration of dating violence. STUDY DESIGN: Young adults (n = 758; 61% female; mean age of 20 years), originally recruited for a longitudinal study as 9th- and 10th-grade Texas high school students, were asked about their childhood experiences with corporal punishment and physical abuse, as well as current experiences with dating violence. A path model was used to determine whether childhood corporal punishment was related to recent perpetration of physical dating violence, while controlling for childhood physical abuse, age, sex, ethnicity, and socioeconomic status...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29202313/comparing-interprofessional-and-interorganizational-collaboration-in-healthcare-a-systematic-review-of-the-qualitative-research
#20
REVIEW
Marlène Karam, Isabelle Brault, Thérèse Van Durme, Jean Macq
BACKGROUND: Interprofessional and interorganizational collaboration have become important components of a well-functioning healthcare system, all the more so given limited financial resources, aging populations, and comorbid chronic diseases. The nursing role in working alongside other healthcare professionals is critical. By their leadership, nurses can create a culture that encourages values and role models that favour collaborative work within a team context. OBJECTIVES: To clarify the specific features of conceptual frameworks of interprofessional and interorganizational collaboration in the healthcare field...
November 11, 2017: International Journal of Nursing Studies
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