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https://www.readbyqxmd.com/read/29155436/enzyme-replacement-therapy-for-infantile-onset-pompe-disease
#1
REVIEW
Min Chen, Lingli Zhang, Shuyan Quan
BACKGROUND: Infantile-onset Pompe disease is a rare and progressive autosomal-recessive disorder caused by a deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). Current treatment involves enzyme replacement therapy (with recombinant human alglucosidase alfa) and symptomatic therapies (e.g. to control secretions). Children who are cross-reactive immunological material (CRIM)-negative require immunomodulation prior to commencing enzyme replacement therapy.Enzyme replacement therapy was developed as the most promising therapeutic approach for Pompe disease; however, the evidence is lacking, especially regarding the optimal dose and dose frequency...
November 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29150982/visualization-within-the-ventricles-of-the-brain-a-micro-focus-x-ray-study
#2
Edwin John de Jager, André Francois du Plessis, Jakobus Willem Hoffman, Anna Catherina Oettlé, Marius Casparus Bosman
Conceptualization of the ventricular system of the brain by macroscopic studies is complicated by the lack of physical structure of these interconnected cavities. Dissection procedures designed to display the structures in the walls of the ventricles are destructive and not conducive for the appreciation of the ventricular system in its entirety. The application of Micro-focus X-ray tomography affords the possibility to appreciate hidden structures in a non-destructive manner. The aim of this study was to explore the possibility of using micro-focus X-ray tomography in the three-dimensional (3D) visualization of the ventricular system as well as the various neuroanatomical structures within its walls for educational purposes...
November 18, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29142374/enhancing-hospital-well-being-and-minimizing-intensive-care-unit-trauma-cushioning-effects-of-psychosocial-care
#3
Usha Chivukula, Meena Hariharan, Suvashisa Rana, Marlyn Thomas, Asher Andrew
Context: Hospitalization has the potential to induce hospital anxiety, while admission in the Intensive Care Unit (ICU) is found to surpass the anxiety and result in what is termed as "ICU Trauma." Aims: This study aimed to determine the impact of psychosocial care and quality of ICU on ICU trauma and hospital well-being in patients who underwent coronary artery bypass grafting (CABG). Settings and Design: This correlational study involved 250 CABG patients, who were recruited from five major corporate hospitals...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29135763/health-system-creation-and-integration-at-a-health-sciences-university-a-five-year-follow-up
#4
Catherine P Slade, Ricardo Azziz, Steven Levin, Gretchen B Caughman, David S Hefner, Kimberly V Halbur, Martha S Tingen, Susan James
Shifting healthcare market forces and regulation have exerted near-constant pressure on U.S. academic health centers (AHCs) attempting to successfully execute their traditional tripartite mission. A governance structure and organizational alignment that works well under one set of conditions is rarely optimal when conditions change. Thus, the degree and type of alignment of an AHC's clinical, educational, and faculty practice organizations have changed regularly within the sector, typically landing near one end or the other on a continuum from fully aligned with centralized governance to largely independent with separate governance...
November 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/29135138/-laparoscopic-radical-cystectomy-innovations-and-classics
#5
D V Perlin, I V Aleksandrov, V P Zipunnikov, M Popova
INTRODUCTION: Radical cystectomy remains the gold-standard treatment for muscle-invasive bladder cancer. To combine the advantages of minimally invasive interventions and the well-established open surgery, we attempted to reproduce as accurately as possible the technique of open radical cystectomy using a laparoscopic procedure. MATERIALS AND METHODS: The study comprised 35 patients (27 men and 8 women) with invasive bladder cancer who underwent laparoscopic radical cystectomy (LRC) between April 2013 and March 2016...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29130230/-protective-measures-in-laparoscopic-resection-for-upper-or-mid-rectal-cancer-and-sigmoid-colon-cancer-with-transrectal-specimen-extraction-surgery
#6
Chuangang Fu, Zhuqing Zhou, Junyi Han, Bin Lu, Wei Gao, Zhe Zhu, Qixin Jiang, Fang Ji, Tao Du
OBJECTIVE: To introduce the use of a self-made specimen protective sleeve in laparoscopic resection for upper or mid rectal cancer and sigmoid colon cancer with transrectal specimen extraction surgery and the improvement of implantation method, so as to avoid and reduce bacterial contamination and tumor cell dissemination in abdominal cavity. METHODS: During June 2015 and May 2017, 48 cases of high located rectal or sigmoid colon cancer were operated laparoscopically with natural orifices specimen extraction surgery (NOSES) using a self-made specimen protecting sleeve...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29119403/evaluation-of-the-efficiency-of-single-inhaler-combination-therapy-with-budesonide-formoterol-fumarate-in-patients-with-bronchial-asthma-in-daily-clinical-practice
#7
Michał Pirożyński, Piotr Hantulik, Agnieszka Almgren-Rachtan, Jerzy Chudek
INTRODUCTION: The effectiveness of single-inhaler budesonide/formoterol fumarate combination therapy for asthma has been previously shown for the original product. The aim of this nonrandomized, open-label, postauthorization efficacy study (PAES) real-life clinical assessment was to evaluate the clinical effectiveness of a second product (Bufomix Easyhaler(®)) in the daily clinical practice of asthma therapy. METHODS: This multicenter PAES was conducted by 220 unselected allergologists and pulmonologists who enrolled 2200 adult outpatients (age 49...
November 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29117816/aaohn-member-opinions-on-demonstrating-value-a-closer-look-at-the-findings
#8
Karen Mastroianni
An assessment was conducted to update a tool kit published by the American Association of Occupational Health Nurses (AAOHN) in 1998. The original document, Success Tool for Measuring and Articulating Value, had been a respected resource. Although the AAOHN guide, Demonstrating Value, is a tool with steps and examples for demonstrating value, the intention of this article is to explore the rich data collected during the assessment process, which included interviews with occupational health nurse leaders and an AAOHN member survey...
November 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/29115991/evaluation-of-the-deki-reader%C3%A2-an-automated-rdt-reader-and-data-management-device-in-a-household-survey-setting-in-low-malaria-endemic-southwestern-uganda
#9
Caesar Oyet, Michelle E Roh, Gertrude N Kiwanuka, Patrick Orikiriza, Martina Wade, Sunil Parikh, Juliet Mwanga-Amumpaire, Yap Boum
BACKGROUND: Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective malaria control tool used in many resource-constrained settings. However, poor quality control and quality assurance hinder the accurate reporting of malaria diagnoses. Recent use of a portable, battery operated RDT reader (Deki Reader™, Fio Corporation) has shown to have high agreement with visual inspection across diverse health centre settings, however evidence of its feasibility and usability during cross sectional surveys are limited...
November 7, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29108078/-big-data-and-public-health-results-of-the-working-group-1-of-the-forum-future-public-health-berlin-2016
#10
Susanne Moebus, Joseph Kuhn, Wolfgang Hoffmann
Big Data is a diffuse term, which can be described as an approach to linking gigantic and often unstructured data sets. Big Data is used in many corporate areas. For Public Health (PH), however, Big Data is not a well-developed topic. In this article, Big Data is explained according to the intention of use, information efficiency, prediction and clustering. Using the example of application in science, patient care, equal opportunities and smart cities, typical challenges and open questions of Big Data for PH are outlined...
November 6, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29103652/appraising-longitudinal-trends-in-the-strategic-risks-cited-by-risk-managers-in-the-international-water-utility-sector-2005-2015
#11
Rosemary T C Chalker, Simon J T Pollard, Paul Leinster, Simon Jude
We report dynamic changes in the priorities for strategic risks faced by international water utilities over a 10year period, as cited by managers responsible for managing them. A content analysis of interviews with three cohorts of risk managers in the water sector was undertaken. Interviews probed the focus risk managers' were giving to strategic risks within utilities, as well as specific questions on risk analysis tools (2005); risk management cultures (2011) and the integration of risk management with corporate decision-making (2015)...
November 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29097946/on-site-chiropractic-care-as-an-employee-benefit-a-single-location-case-study
#12
Salvatore J Minicozzi, Brent S Russell
Objective: The purpose of this report is to describe the role of on-site chiropractic care in one corporate environment. Methods: A part-time chiropractic practice that provides services to a single company on site, 1 day per week, is described. Most care is oriented toward "wellness," is paid for by the employer, and is limited only by the chiropractor's few weekly hours of on-site availability. With approval from the company, the authors conducted an absenteeism analysis after obtaining ethics approval and consent from employee-patients who received care between 2012 and 2014...
September 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29097785/the-nano-architecture-of-the-axonal-cytoskeleton
#13
REVIEW
Christophe Leterrier, Pankaj Dubey, Subhojit Roy
The corporeal beauty of the neuronal cytoskeleton has captured the imagination of generations of scientists. One of the easiest cellular structures to visualize by light microscopy, its existence has been known for well over 100 years, yet we have only recently begun to fully appreciate its intricacy and diversity. Recent studies combining new probes with super-resolution microscopy and live imaging have revealed surprising details about the axonal cytoskeleton and, in particular, have discovered previously unknown actin-based structures...
December 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29079588/pathways-of-undue-influence-in-health-policy-making-a-main-actor-s-perspective
#14
REVIEW
Ildefonso Hernández-Aguado, Elisa Chilet-Rosell
BACKGROUND: It is crucial to know the extent to which influences lead to policy capture-by which the policy-making process is shifted away from the public interest towards narrow private interests. Using the case study of Spain, our aim was to identify interactions between public administration, civil society and private companies that could influence health policies. METHODS: 54 semistructured interviews with key actors related to health policy. The interviews were used to gather information on main policy actors as well as on direct and subtle influences that could modify health policies...
October 27, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29072195/evaluation-of-water-mimicking-solid-phantom-materials-for-use-in-hdr-and-ldr-brachytherapy-dosimetry
#15
Andreas Alexander Schoenfeld, Maike Thieben, Dietrich Harder, Bjoern Poppe, Ndimofor Chofor
In modern HDR or LDR brachytherapy with photon emitters, fast checks of the dose profiles generated in water or a water-equivalent phantom have to be available in the interest of patient safety. However, the commercially available brachytherapy photon sources cover a wide range of photon emission spectra, and the range of the in-phantom photon spectrum is further widened by Compton scattering, so that the achievement of water-mimicking properties of such phantoms involves high requirements on their atomic composition...
October 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29068009/catalytic-reduction-of-so2-by-co-over-au4pt2-co-n-and-au6pt-co-n-clusters-a-first-principles-study
#16
Wei-Feng Xie, Hao-Ran Zhu, Shi-Hao Wei, Da-Yin Hua
The catalytic properties of the magic gold-platinum bimetallic clusters (Au4Pt2 and Au6Pt) for the reduction of SO2 by CO, without or with preadsorbing CO molecules, are firstly investigated using density functional theory calculations. We find that the catalytic activities improve effectively with the preadsorption of CO onto the catalysts and that the catalytic activities of Au6Pt(CO)n are better than those of Au4Pt2(CO)n as more CO molecules are adsorbed onto the catalysts. During the reaction process, the Au4Pt2(CO)n clusters always keep two-dimensional morphologies except for when n = 5 and the Au6Pt(CO)n clusters have three-dimensional geometries except for when n = 0...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29067142/intermittent-96-hour-auricular-electroacupuncture-for-hot-flashes-in-patients-with-prostate-cancer-a-pilot-study
#17
Tyvin Rich, Gerald W Porter, Luisel Ricks-Santi, Tzvi Milshtein, Thomas Corbin
Objective: The hot flash is a common vasomotor disorder that causes distress in menopausal women and that can be debilitating in men with prostate cancer who are treated with androgen deprivation therapy (ADT). The utility of auricular electroacupuncture (AEA) was tested exclusively for a small cohort of men with ADT-induced vasomotor symptoms while the men underwent a course of curative radiotherapy. Materials and Methods: Prior to and during radiotherapy treatment, men with vasomotor symptoms were given repeated questionnaires regarding severity and frequency of hot flashes, quality of life (QoL), and sleep over a 6-week span of an AEA protocol...
October 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/29065799/fitting-tissue-chips-and-microphysiological-systems-into-the-grand-scheme-of-medicine-biology-pharmacology-and-toxicology
#18
David E Watson, Rosemarie Hunziker, John P Wikswo
Microphysiological systems (MPS), which include engineered organoids (EOs), single organ/tissue chips (TCs), and multiple organs interconnected to create miniature in vitro models of human physiological systems, are rapidly becoming effective tools for drug development and the mechanistic understanding of tissue physiology and pathophysiology. The second MPS thematic issue of Experimental Biology and Medicine comprises 15 articles by scientists and engineers from the National Institutes of Health, the IQ Consortium, the Food and Drug Administration, and Environmental Protection Agency, an MPS company, and academia...
October 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29063903/iron-and-vitamin-d-levels-among-autism-spectrum-disorders-children
#19
Abdulbari Bener, Azhar O Khattab, Dinesh Bhugra, Georg F Hoffmann
AIM: The aim of this study was to investigate iron deficiency anemia and Vitamin D deficiency among autism children and to assess the importance of risk factors (determinants). SUBJECTS AND METHODS: This was a case-control study conducted among children suffering from autism at the Hamad Medical Corporation in Qatar. A total of 308 cases and equal number of controls were enrolled. The Autism Diagnostic Observation Schedule-Generic was the instrument used for diagnosis of Autism...
October 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/29060899/unified-health-gamification-can-significantly-improve-well-being-in-corporate-environments
#20
Arash Shahrestani, Pieter Van Gorp, Pascale Le Blanc, Fabrizio Greidanus, Kristel de Groot, Jelle Leermakers
There is a multitude of mHealth applications that aim to solve societal health problems by stimulating specific types of physical activities via gamification. However, physical health activities cover just one of the three World Health Organization (WHO) dimensions of health. This paper introduces the novel notion of Unified Health Gamification (UHG), which covers besides physical health also social and cognitive health and well-being. Instead of rewarding activities in the three WHO dimensions using different mHealth competitions, UHG combines the scores for such activities on unified leaderboards and lets people interact in social circles beyond personal interests...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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