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https://www.readbyqxmd.com/read/28819377/effect-of-pomalidomide-on-relapsed-refractory-multiple-myeloma-a-systematic-review-and-meta-analysis
#1
Runzhe Chen, Yujie Wang, Chengxin Luan, Chong Gao, Xiaoping Zhang, Baoan Chen
In this work, we aim to further analyze the effect of pomalidomide for relapsed and/or refractory multiple myeloma (RRMM). A systematic literature search of PubMed, MEDLINE and EMBASE was conducted on September 20, 2016. Pooled effect size (ES) with corresponding 95% confidence intervals (CIs) were calculated using random-effects model. STATA software (version 12.0; Stata Corporation; College Station, TX, USA) was employed to do all statistical analyses. A total of 8 studies were included for analysis. The combined results demonstrated that the pooled proportion of overall response rate (ORR) was 0...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28816500/research-challenges-in-financial-data-modeling-and-analysis
#2
Lewis Alexander, Sanjiv R Das, Zachary Ives, H V Jagadish, Claire Monteleoni
Significant research challenges must be addressed in the cleaning, transformation, integration, modeling, and analytics of Big Data sources for finance. This article surveys the progress made so far in this direction and obstacles yet to be overcome. These are issues that are of interest to data-driven financial institutions in both corporate finance and consumer finance. These challenges are also of interest to the legal profession as well as to regulators. The discussion is relevant to technology firms that support the growing field of FinTech...
August 17, 2017: Big Data
https://www.readbyqxmd.com/read/28756056/healthcare-costs-related-to-treatment-of-hepatocellular-carcinoma-among-veterans-with-cirrhosis-in-the-united-states
#3
David E Kaplan, Michael K Chapko, Rajni Mehta, Feng Dai, Melissa Skanderson, Ayse Aytaman, Michelle Baytarian, Kathryn D'Addeo, Rena Fox, Kristel Hunt, Christine Pocha, Adriana Valderrama, Tamar H Taddei
BACKGROUND & AIMS: It is important to quantify medical costs associated with hepatocellular carcinoma (HCC), the incidence of which is rapidly increasing incidence in the United States, for development of rational healthcare policies related to liver cancer surveillance and treatment of chronic liver disease. We aimed to comprehensively quantify healthcare costs for HCC among patients with cirrhosis in an integrated health system and develop a model for predicting costs based on clinically relevant variables...
July 26, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28743493/dimensions-of-physical-punishment-and-their-associations-with-children-s-cognitive-performance-and-school-adjustment
#4
Sarah A Font, Jamie Cage
This study examined how a range of physical punishment measures, ranging from mild corporal punishment to physical abuse, are associated with cognitive performance, school engagement, and peer isolation over a 3- year span among 658 children initially observed between the ages of 8 and 14. Physical punishment was captured in three groups: mild corporal punishment, harsh corporal punishment, and physical abuse, and both caregiver- and child-reported punishment measures were considered. After accounting for socioeconomic and demographic characteristics, only Ninitial exposure to physical abuse was significantly associated with declines in cognitive performance...
July 22, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28737623/an-observational-study-of-severe-pertussis-in-100-infants-%C3%A2-120-days-of-age
#5
James D Cherry, Kristen Wendorf, Brooke Bregman, Deborah Lehman, Delma Nieves, John S Bradley, Wilbert H Mason, Linette Sande-Lopez, Merrick Lopez, Myke Federman, Tempe Chen, Dean Blumberg, Samantha Johnston, Hayden T Schwenk, Peggy Weintrub, Kevin K Quinn, Kathleen Winter, Kathleen Harriman
BACKGROUND: Pertussis in young infants is a unique, severe, afebrile, cough illness that is frequently fatal. METHODS: All pertussis cases ≤ 120 days of age admitted to a pediatric intensive care unit (PICU) in California between October 1, 2013 and April 25, 2015 were evaluated. RESULTS: Of 100 pertussis patients ≤ 120 days of age admitted to PICU's, there were 5 deaths. The white blood cell (WBC) counts in the fatal cases were significantly higher than in the non-fatal cases...
July 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28736014/efficacy-and-safety-of-generic-mycophenolate-mofetil-my-rept-500-milligram-tablets-in-primary-liver-transplant-recipients
#6
S K Hong, K-W Lee, K C Yoon, H-S Kim, H Kim, N-J Yi, K-S Suh
BACKGROUND: Generic immunosuppressants may be cost-effective if clinical outcomes are equivalent to the brand-name medications. Mycophenolate mofetil in the form of My-rept may be cost-effective being a generic immunosuppressant, which is available as a 500-mg tablet as well as a 250-mg capsule (Chong Kun Dang Pharmaceutical Corporation, Seoul, Korea). OBJECTIVE: This study aimed to evaluate the efficacy, safety, cost-effectiveness, and convenience of My-rept 500-mg tablets in liver transplant recipients...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28716039/extra-corporeal-membrane-oxygenation-for-refractory-cardiogenic-shock-after-adult-cardiac-surgery-a-systematic-review-and-meta-analysis
#7
Maziar Khorsandi, Scott Dougherty, Omar Bouamra, Vasudev Pai, Philip Curry, Steven Tsui, Stephen Clark, Stephen Westaby, Nawwar Al-Attar, Vipin Zamvar
BACKGROUND: Postcardiotomy cardiogenic shock (PCCS) refractory to inotropic support and intra-aortic balloon pump (IABP) occurs rarely but is almost universally fatal without mechanical circulatory support. In this systematic review and meta-analysis we looked at the evidence behind the use of veno-arterial extra-corporeal membrane oxygenation (VA ECMO) in refractory PCCS from a patient survival rate and determinants of outcome viewpoint. METHODS: A systematic review was performed in January 2017 using PubMed (with no defined time period) using the keywords "postcardiotomy", "cardiogenic shock", "extracorporeal membrane oxygenation" and "cardiac surgery"...
July 17, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28714137/austerity-new-public-management-and-missed-nursing-care-in-australia-and-new-zealand
#8
Eileen Willis, Jenny Carryer, Clare Harvey, Maria Pearson, Julie Henderson
AIMS: To outline the way in which the culture of austerity arising from the Global Financial Crisis has been used by Australian and New Zealand governments to maintain and extend health care budget cuts, through new public management strategies leading to missed nursing care. BACKGROUND: Ten years on the cost of the Global Financial Crisis continues to be borne by tax payers and those employed by the welfare state, yet analysis shows clearly that it was caused by a failure to adequately regulate markets, particularly the banks and multinational corporations...
July 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28705223/improving-preventive-health-care-in-aboriginal-and-torres-strait-islander-primary-care-settings
#9
Jodie Bailie, Veronica Matthews, Alison Laycock, Rosalie Schultz, Christopher P Burgess, David Peiris, Sarah Larkins, Ross Bailie
BACKGROUND: Like other colonised populations, Indigenous Australians experience poorer health outcomes than non-Indigenous Australians. Preventable chronic disease is the largest contributor to the health differential between Indigenous and non-Indigenous Australians, but recommended best-practice preventive care is not consistently provided to Indigenous Australians. Significant improvement in health care delivery could be achieved through identifying and minimising evidence-practice gaps...
July 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28696032/research-review-harnessing-the-power-of-individual-participant-data-in-a-meta-analysis-of-the-benefits-and-harms-of-the-incredible-years-parenting-program
#10
REVIEW
Patty Leijten, Frances Gardner, Sabine Landau, Victoria Harris, Joanna Mann, Judy Hutchings, Jennifer Beecham, Eva-Maria Bonin, Stephen Scott
BACKGROUND: Parenting programs aim to reduce children's conduct problems through improvement of family dynamics. To date, research on the precise benefits and possible harms of parenting programs on family well-being has been unsystematic and likely to be subject to selective outcome reporting and publication bias. Better understanding of program benefits and harms requires full disclosure by researchers of all included measures, and large enough numbers of participants to be able to detect small effects and estimate them precisely...
July 11, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28686879/hematopoietic-stem-cell-transplantation-in-qatar-one-year-anniversary
#11
REVIEW
Mohammad Bakr, Ibrahim Al-Hijji, Naziha Menasria, Zeyd Merenkov, Safaa Al-Azzawi, Ruba Taha, Amaal Gulied, Catherine Anne Gillespie, Said Dermime, Effie Liakopoulou, Alexander Knuth
Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for many hematologic and nonhematologic conditions. As a successful outcome of Qatar's National Cancer Strategy, the HSCT program was started in the National Center for Cancer Care and Research (NCCCR) in October 2015. The HSCT program in NCCCR is the only transplant program in Qatar and self-sufficient with all three core components: the stem cell collection facility, the stem cell processing facility, and the clinical program, which are locally available at Hamad Medical Corporation...
June 29, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28684197/adjustment-to-hand-injury-cross-sectional-survey-exploring-adjustment-in-relation-to-illness-perceptions-and-coping-strategies
#12
Catherine Turkington, Martin Dempster, Jennifer Maguire
STUDY DESIGN: Cross-sectional descriptive. INTRODUCTION: Hand injuries are highly prevalent, and the impact they have on physical, emotional, and functional adjustment is well recognized. Increasingly, adjustment to health conditions including hand injuries is being understood in terms of psychological variables. PURPOSE OF THE STUDY: To examine the role of illness beliefs and coping strategies in adjustment to hand injury. Adjustment was considered from a complete perspective including quality of life (QOL) and functional ability as well as mood and trauma symptoms...
July 3, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28678925/gestational-protein-restriction-increases-cardiac-connexin-43-mrna-levels-in-male-adult-rat-offspring
#13
Kamila Fernanda Rossini, Camila Andrea de Oliveira, Hércules Jonas Rebelato, Marcelo Augusto Marreto Esquisatto, Rosana Catisti
Background: The dietary limitation during pregnancy influences the growth and development of the fetus and offspring and their health into adult life. The mechanisms underlying the adverse effects of gestational protein restriction (GPR) in the development of the offspring hearts are not well understood. Objectives: The aim of this study was to evaluate the effects of GPR on cardiac structure in male rat offspring at day 60 after birth (d60). Methods: Pregnant Wistar rats were fed a normal-protein (NP, 17% casein) or low-protein (LP, 6% casein) diet...
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28654801/hybrid-governance-of-aquaculture-opportunities-and-challenges
#14
Joanna Vince, Marcus Haward
The development of third party assessment and certification of fisheries and aquaculture has provided new forms of governance in sectors that were traditionally dominated by state based regulation. Emerging market based approaches are driven by shareholder expectations as well as commitment to corporate social responsibility, whereas community engagement is increasingly centered on the questions of social license to operate. Third party assessment and certification links state, market and community into an interesting and challenging hybrid form of governance...
June 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28649120/must-we-embody-context
#15
Barbara Hahn
The essays in this forum brace this meditation on the historiography of technology. Understanding devices incorporates the context of any particular hardware, as John Staudenmaier showed by quantifying the contents of the first decades of Technology and Culture. As contextualist approaches have widened from systems theory through social construction and into the assemblages of actor-network theory, the discipline has kept artifacts at the analytical center: it is the history of technology that scholars seek to understand...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28647328/effects-of-feeding-an-immunomodulatory-supplement-to-heat-stressed-or-actively-cooled-cows-during-late-gestation-on-postnatal-immunity-health-and-growth-of-calves
#16
Amy L Skibiel, Thiago F Fabris, Fabiana N Corrá, Yazielis M Torres, Derek J McLean, James D Chapman, David J Kirk, Geoffrey E Dahl, Jimena Laporta
Heat stress during late gestation negatively affects the physiology, health, and productivity of dairy cows as well as the calves developing in utero. Providing cows with active cooling devices, such as fans and soakers, and supplementing cows with an immunomodulating feed additive, OmniGen-AF (OG; Phibro Animal Health Corporation), improves immune function and milk yield of cows. It is unknown if maternal supplementation of OG combined with active cooling during late gestation might benefit the developing calf as well...
September 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28634428/marketization-in-long-term-care-a-cross-country-comparison-of-large-for-profit-nursing-home-chains
#17
Charlene Harrington, Frode F Jacobsen, Justin Panos, Allyson Pollock, Shailen Sutaria, Marta Szebehely
This article presents cross-country comparisons of trends in for-profit nursing home chains in Canada, Norway, Sweden, United Kingdom, and the United States. Using public and private industry reports, the study describes ownership, corporate strategies, costs, and quality of the 5 largest for-profit chains in each country. The findings show that large for-profit nursing home chains are increasingly owned by private equity investors, have had many ownership changes over time, and have complex organizational structures...
2017: Health Services Insights
https://www.readbyqxmd.com/read/28626625/engagement-in-health-and-wellness-an-online-incentive-based-program
#18
Teresa B Gibson, J Ross Maclean, Ginger S Carls, Brian J Moore, Emily D Ehrlich, Victoria Fener, Jordan Goldberg, Elaine Mechanic, Colin Baigel
Increasingly, corporate health promotion programs are implementing wellness programs integrating principles of behavioral economics. Employees of a large firm were provided a customized online incentive program to design their own commitments to meet health goals. This study examines patterns of program participation and engagement in health promotion activities. Subjects were US-based employees of a large, nondurable goods manufacturing firm who were enrolled in corporate health benefits in 2010 and 2011. We assessed measures of engagement with the workplace health promotion program (e...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28621753/media-coverage-of-alcohol-issues-a-critical-political-economy-framework-a-case-study-from-ireland
#19
Julien Mercille
There is a growing literature on news media representations of alcohol-related issues. However, current scholarship has neglected critical political economic frameworks to interpret media coverage of alcohol. This paper presents such a framework that conceives of news organisations as corporations that share the values and interests of political and economic elites. The media are thus expected to present viewpoints that are more aligned with the alcohol industry than the scientific consensus on public health policy would warrant...
June 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28618428/the-impact-of-circulating-mitochondrial-dna-on-cardiomyocyte-apoptosis-and-myocardial-injury-after-tlr4-activation-in-experimental-autoimmune-myocarditis
#20
Bangwei Wu, Huanchun Ni, Jian Li, Xinyu Zhuang, Jinjin Zhang, Zhiyong Qi, Qiying Chen, Zhichao Wen, Haiming Shi, Xinping Luo, Bo Jin
BACKGROUND/AIMS: Mitochondrial DNA (mtDNA), acting as a newly found 'danger-associated molecular patterns' (DAMPs), is released into circulation upon tissue injury and performs as a considerable activator of inflammation and immune response. However, the role of circulating mtDNA in experimental autoimmune myocarditis (EAM) as well as Toll like receptor4 (TLR4) mediated cardiac inflammation and injury remains unknown. METHODS: A model of EAM was established in BALB/c mice by immunization with porcine cardiac myosin...
2017: Cellular Physiology and Biochemistry
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