keyword
https://read.qxmd.com/read/38385463/oxidative-stress-in-polycystic-ovary-syndrome-a-case-control-study
#21
JOURNAL ARTICLE
Syeda Samira Azim, Zeba Haque, Sadaf Khan, Jahan Ara Hasan, Sidra Zaheer, Sajida Parveen
OBJECTIVE: To compare the serum levels of biochemical and oxidative stress markers i.e., malondialdehyde (MDA) and paraoxonase-1(PON1) in polycystic ovary syndrome (PCOS) patients and healthy female individuals of reproductive age group (18-40 years). METHODS: This case-control study was conducted in Dow University of Health Sciences (DUHS), Karachi from June 2019 to October 2020. Seventy Subjects including 35 PCOS patients that have primary subfertility problem (cases) and 35 healthy and fertile females (controls) were recruited...
February 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38374513/increased-oxidative-stress-is-associated-with-hyperandrogenemia-in-polycystic-ovary-syndrome-evidenced-by-oxidized-lipoproteins-stimulating-rat-ovarian-androgen-synthesis-in-vitro
#22
JOURNAL ARTICLE
Renjiao Zhang, Kaifeng Hu, Huai Bai, Hongwei Liu, Yifu Pu, Chunyi Yang, Qingqing Liu, Ping Fan
PURPOSE: To determine the relationship between serum total testosterone (TT) levels and oxidative stress indices in patients with polycystic ovary syndrome (PCOS), and to investigate the effect of oxidative stress on androgen synthesis and its mechanism in rat ovarian theca-interstitial (T-I) cells. METHODS: Clinical, hormonal, metabolic, and oxidative stress parameters were analyzed in a cross-sectional case-control study including 626 patients with PCOS and 296 controls...
February 19, 2024: Endocrine
https://read.qxmd.com/read/38373549/reproductive-toxicity-of-pfoa-pfos-and-their-substitutes-a-review-based-on-epidemiological-and-toxicological-evidence
#23
REVIEW
Wenshan Shi, Zengli Zhang, Mei Li, Huiyu Dong, Jiafu Li
Per- and polyfluoroalkyl substances (PFAS) have already drawn a lot of attention for their accumulation and reproductive toxicity in organisms. Perfluorooctanoic acid (PFOA) and perfluorooctanoic sulfonate (PFOS), two representative PFAS, are toxic to humans and animals. Due to their widespread use in environmental media with multiple toxicities, PFOA and PFOS have been banned in numerous countries, and many substitutes have been produced to meet market requirements. Unfortunately, most alternatives to PFOA and PFOS have proven to be cumulative and highly toxic...
February 17, 2024: Environmental Research
https://read.qxmd.com/read/38370884/comparing-the-effects-of-cyperus-esculentus-hydroethanolic-extract-and-euterpe-oleracea-on-reproductive-efficacy-against-cadmium-induced-testicular-toxicity-in-male-rats
#24
JOURNAL ARTICLE
Sura Safi Khafaji
OBJECTIVE: Cadmium chloride (CdCl2 ) is an environmentally toxic pollutant that can cause reprotoxicity. Cyperus esculentus and Euterpe oleracea are potent antioxidant plants currently used to counteract the action of harmful pollutants. The present experiment was intended to evaluate and comp are the role of C. esculentus hydroethanolic extract (CHE) and E. oleracea in treating the reprotoxicity induced by CdCl2 in rats. MATERIALS AND METHODS: Forty adult male rats (160-210 gm) were allocated into five groups equally...
December 2023: Journal of Advanced Veterinary and Animal Research
https://read.qxmd.com/read/38365877/kaempferol-mitigates-reproductive-dysfunctions-induced-by-naja-nigricollis-venom-through-antioxidant-system-and-anti-inflammatory-response-in-male-rats
#25
JOURNAL ARTICLE
Akindele Oluwatosin Adeyi, Babafemi Siji Ajisebiola, Akanni Abubakar Sanni, Johnson Olaleye Oladele, Abdur-Rahman Kolawole Mustapha, Omotayo Opemipo Oyedara, Olukunle Silas Fagbenro
Naja nigricollis Venom (NnV) contains complex toxins that affects various vital systems functions after envenoming. The venom toxins have been reported to induce male reproductive disorders in envenomed rats. This present study explored the ameliorative potential of kaempferol on NnV-induced male reproductive toxicity. Fifty male wistar rats were sorted randomly into five groups (n = 10) for this study. Group 1 were noted as the control, while rats in groups 2 to 5 were injected with LD50 of NnV (1...
February 16, 2024: Scientific Reports
https://read.qxmd.com/read/38364740/involvement-of-nrf2-ppar-%C3%AE-signaling-in-coenzyme-q10-protecting-effect-against-methotrexate-induced-testicular-oxidative-damage
#26
JOURNAL ARTICLE
El-Shaimaa A Arafa, Emad H M Hassanein, Nihal A Ibrahim, Manal A Buabeid, Wafaa R Mohamed
Studies have identified Coenzyme Q10 (CoQ10) as a promising agent in improving idiopathic male infertility; however, its role in chemically or environmentally induced testicular dysfunction is not well-established. We investigated the potential of CoQ10 to attenuate methotrexate (MTX)-induced testicular damage and to identify molecular targets of CoQ10 effects. Wistar rats received a single intraperitoneal dose of 20 mg/kg MTX on the fifth day of the 10-day experimental protocol. 100 mg/kg CoQ10 was given orally daily for ten days, alone or combined with MTX...
February 14, 2024: International Immunopharmacology
https://read.qxmd.com/read/38353742/long-noncoding-rna-xist-inhibition-promotes-leydig-cell-apoptosis-by-acting-as-a-competing-endogenous-rna-for-microrna-145a-5p-that-targets-sirt1-in-late-onset-hypogonadism
#27
JOURNAL ARTICLE
Jing Wang, Yiqiong Yang, Yang Xu, Zhipeng Xu, Xiaozhi Zhao, Ruipeng Jia, Yutian Dai
Leydig cell (LCs) apoptosis is responsible for decreased serum testosterone levels during late-onset hypogonadism (LOH). Our study was designed to illustrate the regulatory effect of lncRNA XIST on LCs and to clarify its molecular mechanism of action in LOH. The Leydig cells (TM3) was treated by 300 μM H2 O2 for 8 h to establish Leydig cell oxidative stress model in vitro. The expression levels of lncRNA XIST in the testicular tissues of patients with LOH were measured using fluorescence in situ hybridization (FISH)...
February 14, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38348645/selenium-mitigates-methotrexate-induced-testicular-injury-insights-from-male-nmri-mice-model
#28
JOURNAL ARTICLE
Mohammadreza Gholami, Afsaneh Nemati, Azita Alasvand Zarasvand, Abolfazl Zendehdel, Cyrus Jalili, Iraj Rashidi, Kamran Mansouri, Forough Taheri, Vahideh Assadollahi, Elham Gholami
BACKGROUND AND AIM: Chemotherapy, particularly with methotrexate (MTX), often elicits testicular toxicity, leading to impaired spermatogenesis and hormone imbalances. This study aimed to investigate the potential protective effects of selenium (Se) against MTX-induced testicular injury. MATERIALS AND METHODS: Male mice were divided into control, MTX, Se, and MTX + Se groups. Histopathological examination involved the preparation of testicular tissue sections using the Johnsen's tubular biopsy score (JTBS) for spermatogenesis evaluation...
February 2024: Birth Defects Research
https://read.qxmd.com/read/38344831/ameliorating-diabetes-induced-testicular-dysfunction-by-modulating-pkc-nrf2-bcl-2-signaling-protective-role-of-sulbutiamine
#29
JOURNAL ARTICLE
Maha Abdelmonem, Shimaa O Ali, Asmaa K Al-Mokaddem, Heba R Ghaiad
The prevalence of testicular dysfunction is increasing as it is a common diabetes mellites (DM) complication. The objective of this study is to explore the potential protective effect of sulbutiamine against testicular hypofunction associated with streptozotocin (STZ)-induced DM in rats. Sulbutiamine was administered orally (60 mg/kg) to male Wistar rats for 8 weeks starting 72 h after a single injection of STZ (45 mg/kg, i.p.). Blood glucose level (BGL), serum testosterone level, sperm number, and motility were determined...
February 12, 2024: BioFactors
https://read.qxmd.com/read/38340662/effects-of-dietary-moringa-oleifera-leaf-extract-on-semen-characteristics-fertility-and-hatchability-in-aged-broiler-breeder-roosters
#30
JOURNAL ARTICLE
Michael Ghadimi, Abouzar Najafi, Seyed Davood Sharifi, Abdollah Mohammadi-Sangcheshmeh, Mohammad Roostaei-Ali Mehr
Declining semen quality will have a negative impact on the fertility of aged roosters. Various factors influence this decrease in quality. This study was conducted to investigate the effects of different levels of Moringa plant extract on semen characteristics, fertility, and hatchability in aged broiler breeder roosters. A total of 24 roosters were fed 1 of 4 dietary supplements for 10 wk: Control, 100 μL/kg (Moringa oleifera leaf extract [MOLE]-100), 200 μL/kg (MOLE-200), or 400 μL/kg body weight (MOLE-400) of Moringa oleifera extract...
January 24, 2024: Poultry Science
https://read.qxmd.com/read/38323592/hydroxycitric-acid-and-capsaicin-combination-alleviates-obesity-induced-testicular-apoptosis-oxidative-stress-and-inflammation
#31
JOURNAL ARTICLE
V V Sathibabu Uddandrao, Seshathri Eraniappan, Asokan Balakrishnan Ramajayam, Sengottuvelu Singaravel, Anitha Roy, Brahma Naidu Parim, Chandrasekaran Ponnusamy, Saravanan Ganapathy, Ponmurugan Ponnusamy, Vadivukkarasi Sasikumar
Recent research in rodents suggests that oxidative stress, inflammation, and apoptosis in the testes caused by high-fat diets (HFD) are a cause of male infertility. To investigate the therapeutic efficacy of the combination of hydroxycitric acid and capsaicin (HCC) against male reproductive disorders, we developed an HFD-induced obese rat model. Rats received HFD supplementation for 21 weeks, which induced obesity. From week 16, HCC (100 mg/kg body weight) was administered to investigate its potential to treat testicular toxicity...
December 2024: Systems Biology in Reproductive Medicine
https://read.qxmd.com/read/38320369/ursonic-acid-attenuates-spermatogenesis-in-oligozoospermia-mice-through-inhibiting-ferroptosis
#32
JOURNAL ARTICLE
Jin Dong, Yanli Dong, Hanqing Chen, Taowen Ye, Guangtong Chen, Boyi Fan, Xiaorong Wang, Jianwu Shi, Chengniu Wang
Ursonic acid (UNA) is a natural pentacyclic triterpene found in some medicinal plants and foods. The reproductive protective effect of UNA was evaluated in a mouse model of oligozoospermia induced by busulfan (BUS) at 30 mg/kg b.w.. The mice were initially divided into groups with UNA concentrations of 10, 30, 50, 100 mg/kg. Subsequently, based on sperm parameters, the optimal concentration of 50 mg/kg was identified. As a control, an additional group was supplemented with ursolic acid at a concentration of 50 mg/kg...
February 3, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38307943/zinc-oxide-resveratrol-nanoparticles-ameliorate-testicular-dysfunction-due-to-levofloxacin-induced-oxidative-stress-in-rats
#33
JOURNAL ARTICLE
Naglaa F Zaki, Sahar H Orabi, Hend Mohamed Abdel-Bar, Hamed T Elbaz, Reda M S Korany, Ayman K Ismail, Walid M Daoush, Maram H Abduljabbar, Manal E Alosaimi, Reem M Alnemari, Heba H Mahboub, Mohamed M Ahmed
The present work is aimed to assess the protective influence of zinc oxide resveratrol nanoparticles against oxidative stress-associated testicular dysfunction. The number of 50 male albino rats were randomly separated into five groups (n = 10): Group I, control: rats gavage distilled water orally; Group II, Levofloxacin: rats that administered Levofloxacin (LFX) softened in distilled water at a dosage of 40 mg/kg-1 BW orally every other day; Group III, Zn-RSV: rats administered with Zn-RSV (zinc oxide resveratrol in distilled water at a dose 20 mg/kg-1 BW orally every other day; Group IV, (LFX + Zn-RSV): rats that were administered with Levofloxacin along with Zn-RSV nPs; Group V, Levofloxacin + Zn: rats were administered with Levofloxacin and Zno at a dose of 20 mg/kg-1 BW orally every other day as mentioned before...
February 2, 2024: Scientific Reports
https://read.qxmd.com/read/38298044/ethanol-extract-of-aloe-vera-ameliorates-artemether-lumefantrine-induced-reproductive-toxicity-in-adult-male-albino-rats-wistar-strain
#34
JOURNAL ARTICLE
Mustapha Olamide Oluwayemisi, Fatola Olanrewaju, Ola-Davies Olufunke, Ajayi Olusola Lawrence, Oyeyemi Matthew
Artemether-Lumefantrine (AL) is one of the alternative drugs used in treating malaria - an endemic scourge in Africa. AL has been reported to generate free radicals with long term use implicated in testicular pathologies. The antioxidative properties of Aloe vera (AV) has been well documented. This study investigated the ameliorative effect of ethanol extract of Aloe Vera on Artemether-Lumefantrine induced testicular toxicity. Thirty adult male albino rats were randomly divided into 5 groups (Control, AL-dosed, AV-dosed, AL+AV concurrently administered and AV-pretreated)...
December 2023: Environmental analysis, health and toxicology
https://read.qxmd.com/read/38292720/antioxidant-anti-inflammatory-and-anti-reprotoxic-effects-of-kaempferol-and-vitamin-e-on-lead-acetate-induced-testicular-toxicity-in-male-rats
#35
JOURNAL ARTICLE
Sura Safi Khafaji
BACKGROUND: The heavy metals cause repro-toxicity via oxidative stress and suppress the antioxidant enzymes. Kaempferol and vitamin E possess antioxidant properties that can counteract the deleterious heavy metals effects. AIM: The present study was directed to investigate the protective role of kaempferol, alone or with vitamin E, on testicular toxicity mediated by lead acetate in male rats. METHODS: Fifty adult male rats were randomly grouped into five groups ( n = 10): the control group received 5 ml distilled water, and the Pb group was intraperitoneally injected with 20 mg/kg of lead acetate...
December 2023: Open Veterinary Journal
https://read.qxmd.com/read/38288132/protective-effects-of-vanillic-acid-on-letrozole-induced-polycystic-ovarian-syndrome-a-comprehensive-study-in-female-wistar-rats
#36
JOURNAL ARTICLE
Pradnya V Gadhave, Guruprasad V Sutar, Sachin J Sajane, Vivekkumar K Redasani, Kuntal Das, Dharani Prasad P, Saad Alobid, Ali Ibrahim Almoteer, Syed Imam Rabbani, Farhana Yasmin, Rafiulla Gilkaramenthi, Majidah Abdulrazaq AlAnazi, Haya Jameel Alshamrani, Syed Mohammed Basheeruddin Asdaq
BACKGROUND: Polycystic ovarian syndrome (PCOS) is one of the known causes of anovulatory fertility in the world. Previous research has linked oxidative stress could contribute to PCOS, and vanillic acid has shown antioxidant potential. Hence, the present study evaluated the effect of vanillic acid on letrozole-induced polycystic ovarian syndrome in female rats. MATERIALS AND METHODS: PCOS was induced in Wistar female rats with letrozole (1 mg/kg, orally) in carboxymethoxycellulose (1 % w/v), administered for 21 days...
February 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38286926/ginkgo-biloba-extract-protects-against-tartrazine-induced-testicular-toxicity-in-rats-involvement-of-antioxidant-anti-inflammatory-and-anti-apoptotic-mechanisms
#37
JOURNAL ARTICLE
Amina Essawy, Shreen Matar, Nema Mohamed, Wessam Abdel-Wahab, Heba Abdou
The use of additives, especially colorants, in food and pharmaceutical industry is increasing dramatically. Currently, additives are classified as contaminants of emerging concern (CECs). Concerns have been raised about the potential hazards of food additives to reproductive organs and fertility. The present study investigates the reproductive toxicity of tartrazine (TRZ), a synthetic colorant, in male rats and aims to explore the curative effect of Ginkgo biloba extract (EGb) against TRZ-induced testicular toxicity...
February 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38286208/mechanism-and-impact-of-heavy-metal-aluminum-al-toxicity-on-male-reproduction-therapeutic-approaches-with-some-phytochemicals
#38
REVIEW
Fares E M Ali, Khalid S A Badran, Mohammad A Baraka, Hanan S Althagafy, Emad H M Hassanein
Heavy metals are ubiquitous environmental toxicants that have been known to have a serious effect on human and animal health. Aluminum (Al) is a widely distributed metal in nature. Al exposure has a detrimental impact on human fertility. This review focused on Al-induced male reproductive toxicity and the potential therapeutic approaches with some phytochemicals. Data from the literature showed that Al exposure is accompanied by a drastic decline in blood levels of FSH, LH, and testosterone, reduced sperm count, and affected sperm quality...
January 27, 2024: Life Sciences
https://read.qxmd.com/read/38283184/-allium-ampeloprasum-var-porrum-alliaceae-improves-metabolic-and-reproductive-disorders-associated-with-polycystic-ovary-syndrome-in-wistar-rats
#39
JOURNAL ARTICLE
Alison Degrace Fofie Tedongmo, Marie Alfrede Mvondo
To provide scientific evidence of the efficacy of Allium ampeloprasum against female infertility, the effects of the aqueous extract of the said plant (AE) were evaluated in rats with letrozole-induced polycystic ovary syndrome (PCOS). AE was administered orally to PCOS rats at doses of 192, 384, and 768 mg/kg. The positive control was co-treated with clomiphene citrate (1 mg/kg) and metformin (200 mg/kg). Normal and negative controls received distilled water. The vaginal contents of rats were examined daily under a microscope before (7 days) and during treatment...
2024: Biochemistry Research International
https://read.qxmd.com/read/38278498/a-low-dose-of-benzo-a-pyrene-during-prepuberty-in-male-rats-generated-immediate-oxidative-stress-in-the-testes-and-compromised-steroidogenic-enzymes-proteins
#40
JOURNAL ARTICLE
Bárbara Campos Jorge, Ana Carolina Casali Reis, Julia Stein, Beatriz Rizzo Paschoalini, Jéssica Nogueira Bueno, Suyane da Silva Moreira, Alana Rezende Godoi, Vanessa Caroline Fioravante, Francisco Eduardo Martinez, Patrícia Fernanda Felipe Pinheiro, Arielle Cristina Arena
The prepubertal period is crucial for sexual development and any alterations can interfere with the reproductive system in adulthood. The aim of this study was to evaluate how Benzo(a)pyrene (BaP) can affect the testes during the prepubertal period. Juvenile male Wistar rats were divided into a control (corn oil + DMSO) and a BaP-group (0.1μg/kg/day), exposed to BaP for 31 days (gavage), and all parameters were evaluated on postnatal day (PND) 54. Leukocyte counts were decreased. Histological analyses of the testes revealed that height and seminiferous tubules diameters (STDs) were reduced, tubular dynamics were altered, and Leydig cell atrophy was evident in the BaP-group...
January 24, 2024: Reproductive Toxicology
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