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Oxidative stress and testosterone

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https://www.readbyqxmd.com/read/29164652/cerium-oxide-nanoparticle-elicits-oxidative-stress-endocrine-imbalance-and-lowers-sperm-characteristics-in-testes-of-balb-c-mice
#1
O A Adebayo, O Akinloye, O A Adaramoye
The toxicity of metallic nanoparticles is a growing concern due to its application in industries and homes. We investigated the toxicity of cerium oxide nanoparticles (CeO2 NPs) on reproductive system in male balb/c mice. Twenty mice were divided into four groups of five animals each and treated thus: normal saline (control), 100, 200 and 300 μg/kg CeO2 NPs (i.p.,) thrice in a week for five consecutive weeks. Results showed that CeO2 NPs significantly reduced the levels of haemoglobin, PCV and RBC count relative to controls...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29127912/pesticides-contaminated-dust-exposure-risk-diagnosis-and-exposure-markers-in-occupational-and-residential-settings-of-lahore-pakistan
#2
Sidra Waheed, Crispin Halsall, Andrew J Sweetman, Kevin C Jones, Riffat Naseem Malik
There are few studies documenting the dust loaded with pesticides as a potential non-dietary exposure source for occupational worker and populations living near agricultural farms and pesticides formulation plants. In present study we have evaluated the pesticide concentration in dust from potential sites and relevant health risk from dust ingestion. Furthermore, the effect of currently used pesticides was investigated on blood and urine parameters of subjects: farmer, factory worker, urban resident and rural resident and controlled subjects with presumably different levels of exposure...
November 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29123386/geroprotectors-as-a-therapeutic-strategy-for-copd-where-are-we-now
#3
REVIEW
Joanna Miłkowska-Dymanowska, Adam J Białas, Joanna Makowska, Aleksandra Wardzynska, Paweł Górski, Wojciech J Piotrowski
Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality. There are still many gaps in knowledge about the cellular, molecular, and genetic mechanisms contributing to pathobiology of this disease. However, increasing evidence suggests that accelerated aging, chronic systemic inflammation, and oxidative stress play major roles in pathogenesis in COPD, thus opening new opportunities in therapy. Therefore, the aim of our review was to describe and discuss some of the most widely used therapeutics that affect the root cause of aging and oxidative stress (metformin, melatonin, sirolimus, statins, vitamin D, and testosterone) in context of COPD therapy...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29105496/a-helicobacter-pylori-associated-insulin-resistance-in-asymptomatic-sedentary-young-men-does-not-correlate-with-inflammatory-markers-and-urine-levels-of-8-iso-pgf2-%C3%AE-or-1-4-dihydroxynonane-mercapturic-acid
#4
Andriy Cherkas, Sergii Golota, Françoise Guéraud, Orest Abrahamovych, Christoph Pichler, Armen Nersesyan, Volodymyr Krupak, Vira Bugiichyk, Ostap Yatskevych, Mykhaylo Pliatsko, Peter Eckl, Siegfried Knasmüller
A potential contribution of H. pylori contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 H. pylori negative and 12 positive) and measured whole blood glucose, glycated haemoglobin, insulin, C-peptide, cortisol, aldosterone, testosterone, thyroid stimulating hormone, C-reactive protein, interleukins 6 and 10, TNF-alpha and comet assay...
November 6, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29103113/testicular-toxicity-and-sperm-quality-following-copper-exposure-in-wistar-albino-rats-ameliorative-potentials-of-l-carnitine
#5
Maurya Khushboo, Meesala Krishna Murthy, Maibam Sunita Devi, Sanasam Sanjeev, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian
Copper is a persistent toxic and bio-accumulative heavy metal of global concern. Continuous exposure of copper compounds of different origin is the most common form of copper poisoning and in turn adversely altering testis morphology and function and affecting sperm quality. L-carnitine has a vital role in the spermatogenesis, physiology of sperm, sperm production and quality. This study was designed to examine whether the detrimental effects of long-term copper consumption on sperm quality and testis function of Wistar albino rat could be prevented by L-carnitine therapy...
November 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29091894/zinc-alogliptin-combination-attenuates-testicular-toxicity-induced-by-doxorubicin-in-rats-role-of-oxidative-stress-apoptosis-and-tgf-%C3%AE-1-nf-%C3%AE%C2%BAb-signaling
#6
Ahmed M Kabel
The aim of this study was to assess the effect of alogliptin and/or zinc on doxorubicin (DOX)-induced testicular toxicity in rats. Sixty male Wistar rats were divided into 6 equal groups: Control; DOX; DOX+Zinc; DOX+Alogliptin; DOX+Carboxymethyl cellulose and DOX+Zinc+Alogliptin. Testis weight, testicular functions, serum testosterone, luteinizing hormone, follicle stimulating hormone and zinc were measured. Also, testicular tissue zinc, 3 β-hydroxysteroid dehydrogenase, 17 β- hydroxysteroid dehydrogenase, antioxidant enzymes, pro-inflammatory cytokines, transforming growth factor beta 1 (TGF-β1), nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and sperm characteristics were assessed...
October 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29091864/taurine-enhances-spermatogenic-function-and-antioxidant-defense-mechanisms-in-testes-and-epididymis-of-l-name-induced-hypertensive-rats
#7
Isaac A Adedara, Sanmi E Alake, Mercy O Adeyemo, Laide O Olajide, Temitayo O Ajibade, Ebenezer O Farombi
The beneficial health effects of taurine on hypertension have been demonstrated previously in both experimental and epidemiological studies. However, the role of taurine in reproductive dysfunction associated with hypertension has not been investigated. The present study evaluated the therapeutic efficacy of taurine on reproductive deficits in N-nitro-l-arginine methyl ester (L-NAME)-induced hypertensive rats. Sixty male Wistar rats were randomly assigned into six groups namely control, taurine alone, L-NAME alone (40mg/kg) or L-NAME treated with either taurine (100 and 200mg/kg) or reference drug atenolol (10mg/kg) for 28 consecutive days...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080463/ameliorative-effects-of-bee-pollen-and-date-palm-pollen-on-the-glycemic-state-and-male-sexual-dysfunctions-in-streptozotocin-induced-diabetic-wistar-rats
#8
Nema A Mohamed, Osama M Ahmed, Walaa G Hozayen, Marium A Ahmed
This study aimed to assess the effects of bee pollen (BP) and/or date palm pollen (DPP) suspensions on the glycemic state, testicular dysfunctions, oxidative stress and antioxidant defense system in streptozotocin (STZ)-induced diabetic male Wistar rats. Diabetes mellitus was induced by single intraperitoneal injection of STZ to overnight-fasted rats at dose of 40mg/kg body weight. After 1 week of STZ injection, diabetic rats were treated with BP and/or DPP suspensions at dose levels of 100mg/kg body weight/day for 4 weeks...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29076302/restoration-of-spermatogenesis-using-a-new-combined-herbal-formula-of-epimedium-koreanum-nakai-and-angelica-gigas-nakai-in-an-luteinizing-hormone-releasing-hormone-agonist-induced-rat-model-of-male-infertility
#9
Hyun Jun Park, Yean Kyoung Koo, Min Jung Park, Yoon Kyung Hwang, Sung Yeoun Hwang, Nam Cheol Park
PURPOSE: We investigated the protective effect of a mixture of 2 herbal extracts, KH-465, which consisted of Epimedium koreanum Nakai and Angelica gigas Nakai, on spermatogenesis in a luteinizing hormone-releasing hormone (LHRH) agonist-induced rat model of male infertility. MATERIALS AND METHODS: Seventy-five 12-week-old male Sprague-Dawley rats were randomly divided into 5 groups, containing 15 rats each: a normal control group that received no treatment and 4 experimental groups (I, II, III, and IV) in which an LHRH agonist was administered for 4 weeks to induce spermatogenic failure...
October 25, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29075365/antioxidant-and-antifibrotic-effect-of-a-herbal-formulation-in-vitro-and-in-the-experimental-andropause-via-nrf2-ho-1-signaling-pathway
#10
Woong Jin Bae, Guan Qun Zhu, Sae Woong Choi, Hyun Cheol Jeong, Fahad Bashraheel, Kang Sup Kim, Su Jin Kim, Hyuk Jin Cho, U Syn Ha, Sung Hoo Hong, Ji Youl Lee, Hyun-A Oh, Hye Cheong Koo, Do Ram Kim, Sung Yeoun Hwang, Sae Woong Kim
The Korean herbal formulation Ojayeonjonghwan is used for improving late-onset hypogonadism (LOH) symptoms such as erectile dysfunction (ED). A previous research suggested that a modified Ojayeonjonghwan (KH-204) could be used as an alternative to the treatment for ED. The pharmacological effects were examined in different conditions, including in vitro and in vivo. We measured the survival rate of TM3 Leydig cells under the oxidative stress condition. The s.c. injection of leuprorelin was used to induce androgen deprivation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29065927/the-protective-role-of-estrogen-and-estrogen-receptors-in-cardiovascular-disease-and-the-controversial-use-of-estrogen-therapy
#11
REVIEW
Andrea Iorga, Christine M Cunningham, Shayan Moazeni, Gregoire Ruffenach, Soban Umar, Mansoureh Eghbali
Epidemiologic studies have previously suggested that premenopausal females have reduced incidence of cardiovascular disease (CVD) when compared to age-matched males, and the incidence and severity of CVD increases postmenopause. The lower incidence of cardiovascular disease in women during reproductive age is attributed at least in part to estrogen (E2). E2 binds to the traditional E2 receptors (ERs), estrogen receptor alpha (ERα), and estrogen receptor beta (ERβ), as well as the more recently identified G-protein-coupled ER (GPR30), and can exert both genomic and non-genomic actions...
October 24, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/29057334/antouka-super-%C3%A2-induced-oxidative-stress-and-reproductive-toxicity-in-male-japanese-quail-coturnix-coturnix-japonica
#12
Ngoula Ferdinand, Ngoumtsop Victor Herman, Ngouateu Kenfack Omer Bebe, Kenfack Augustave, Mutwedu Valence, Nguemmogne Tamdem Ghislaine, Tchoffo Herve, Azafack Kana Dorice, Deutcheu Sorelle, Manjeli Yacouba
BACKGROUND: Antouka Super(®) (AS), a combination of insecticide (Pirimiphos-methyl 16% and Permethrin 3%), is one of the most widely used pesticides in agriculture, public health, home and garden, with high potential for human and animal exposure. OBJECTIVE: The present study was undertaken to evaluate the effect of AS on the serum testosterone, oxidative stress biomarkers, testis histology and fertility of male Japanese quail. METHODS: Thirty-two (32) male Japanese quails twenty-eight (28) days were randomly divided into four groups: C0 (control), T1, T2 and T3, exposed daily (gavage) to 0, 37...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29052001/quail-coturnix-japonica-egg-yolk-bioactive-components-attenuate-streptozotocin-induced-testicular-damage-and-oxidative-stress-in-diabetic-rats
#13
Gideon Oludare Oladipo, Chidinma Martha Nlekerem, Emmanuel Oluwafemi Ibukun, Ayodele Oluseyi Kolawole
INTRODUCTION: The testicular milieu is the machinery for the metabolism of testosterone in the male reproductive system. PURPOSE: The dysfunction of this highly regenerating system is inevitable in the condition of glucose imbalance as a result of insulin machinery impairment. Therefore, it is imperative to recommend dietary intervention for attenuating the testicular dysfunction and oxidative stress resulting from STZ-induction of diabetes. METHODS: STZ-induced diabetes (65 mg/kg, ip) was treated with QEYEM (50, 100 and 200 mg/kg/day) and quercetin (50 mg/kg/day) for 7weeks...
October 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29047156/cyclophosphamide-induced-male-subfertility-in-mice-an-assessment-of-the-potential-benefits-of-maca-supplement
#14
A Y Onaolapo, B P Oladipo, O J Onaolapo
Effects of Lepidium meyenii (Maca) on cyclophosphamide (CYP)-induced gonadal toxicity in male mice were investigated. Mice were assigned to six treatment groups: Vehicle control, CYP control, CYP plus oral Maca (500 or 1,000 mg/kg), and oral Maca (500 or 1,000 mg/kg). CYP was administered via the intraperitoneal route (days 1-2), while vehicle or Maca were administered daily for 28 days. On day 28, half of the animals in each group were either sacrificed or paired with age-matched females for fertility assessment...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/29037103/ameliorative-effect-of-myo-inositol-on-red-blood-cell-alterations-in-polycystic-ovary-syndrome-in-vitro-study
#15
Alessandra Andrisani, Gabriella Donà, Chiara Sabbadin, Elena Tibaldi, Francesco Dessole, Valentina Bosello Travain, Loris Marin, Anna Maria Brunati, Guido Ambrosini, Decio Armanini, Eugenio Ragazzi, Luciana Bordin
Polycystic ovary syndrome (PCOS)is a gynecological endocrine disorder which is associated with systemic inflammatory status inducing red blood cells (RBC) membrane alterations related to insulin resistance and testosterone levels which could be greatly improved by myo-inositol (MYO) uptake. In this study we aim to evaluate the effect of MYO in reducing oxidative-related alterations through in vitro study on PCOS RBC. Blood samples from two groups of volunteers, control group (CG, n = 12) and PCOS patient group (PG, n = 12), were analyzed for band 3 tyrosine phosphorylation (Tyr-P), high molecular weight aggregate (HMWA), IgG in RBC membranes, and glutathione (GSH) in cytosol, following O/N incubation in the presence or absence of MYO...
October 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29030260/cyanidin-3-o-glucoside-promotes-the-biosynthesis-of-progesterone-through-the-protection-of-mitochondrial-function-in-pb-exposed-rat-leydig-cells
#16
Luona Wen, Xinwei Jiang, Jianxia Sun, Xia Li, Xusheng Li, Lingmin Tian, Ye Li, Weibin Bai
Cyanidin-3-O-glucoside (C3G) is an anthocyanin that has been reported to reduce the toxicity of heavy metals. In the present study, the protection effects of C3G on the biosynthesis of progesterone, the precursor of testosterone, against lead (Pb) in R2C rat Leydig cells were examined. Treatment of R2C cells with 100 μM Pb resulted in a significant decrease in progesterone production. After being cultured in a medium containing C3G and Pb, R2C cells exhibited an increase in progesterone concentration compared with the Pb treatment, as a result of up-regulation of the expression of the steroidogenic enzymes steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase (3β-HSD) and cytochrome P450 enzyme cholesterol side chain cleavage enzyme (CYP11A1)...
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28969511/interactive-effects-of-chronic-stress-and-a-high-sucrose-diet-on-nonalcoholic-fatty-liver-in-young-adult-male-rats
#17
Adriana Corona-Pérez, Mauricio Díaz-Muñoz, Estela Cuevas-Romero, Dalia Luna-Moreno, Héctor Valente-Godínez, Olivia Vázquez-Martínez, Margarita Martínez-Gómez, Jorge Rodríguez-Antolín, Leticia Nicolás-Toledo
Glucocorticoids have been implicated in nonalcoholic fatty liver diseases (NAFLD). The influence of a palatable diet on the response to stress is controversial. This study explored whether a high-sucrose diet could protect from hepatic steatosis induced by chronic restraint stress in young adult rats. Male Wistar rats aged 21 days were allocated into four groups (n = 6-8 per group): control, chronic restraint stress, 30% sucrose diet, and 30% sucrose diet plus chronic restraint stress. After being exposed to either tap water or sucrose solution during eight weeks, half of the rats belonging to each group were subject or not to repeated restraint stress (1 h per day, 5 days per week) during four weeks...
October 2, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28968462/dietary-docosahexaenoic-acid-supplementation-prevents-the-formation-of-cholesterol-oxidation-products-in-arteries-from-orchidectomized-rats
#18
Diva M Villalpando, Mibsam M Rojas, Hugo S García, Mercedes Ferrer
Testosterone deficiency has been correlated with increased cardiovascular diseases, which in turn has been associated with increased oxidative stress. Several studies have considered cholesterol oxidation products (COPs) as oxidative stress biomarkers, since some of them play pro-oxidant and pro-inflammatory roles. We have previously described the cardioprotective effects of a dosahexaenoic acid (DHA) supplemented diet on the aortic and mesenteric artery function of orchidectomized rats. The aim of this study was to investigate whether impaired gonadal function alters the formation of COPs, as well as the potential preventive role of a DHA-supplemented diet on that effect...
2017: PloS One
https://www.readbyqxmd.com/read/28965657/interactive-effects-of-ethanol-on-ulcerative-colitis-and-its-associated-testicular-dysfunction-in-pubertal-balb-c-mice
#19
Isaac A Adedara, Babajide O Ajayi, Ifeoluwa O Awogbindin, Ebenezer O Farombi
Available epidemiological reports have indicated an increase in the incidence of ulcerative colitis, as well as alcohol consumption, globally. The present study investigated the possible interactive effects of ethanol consumption on ulcerative colitis and its associated testicular dysfunction using six groups of 12 pubertal mice each. Group I (Control) mice received drinking water alone. Group II mice received ethanol alone at 5 g/kg body weight. Group III mice received 2.5% dextran sulphate sodium (DSS) in drinking water followed by normal drinking water...
November 2017: Alcohol
https://www.readbyqxmd.com/read/28965259/sexual-activity-affects-the-redox-profile-along-the-aging-process-in-male-rats
#20
Tiago Boeira Salomon, Mara Silveira Benfato
The disposable soma theory postulates that aging might be the result of tradeoffs between early life reproduction and longevity, thereby involving the costs of reproduction in the expected lifespan. It is known that redox biochemistry plays a major role in these processes. To assess long term effects of reproduction, we analyzed redox rates and the testosterone levels at four different ages, and we performed a principal component analysis between redox measures of five different organs followed by a cluster analysis to determine correlations...
September 30, 2017: Biogerontology
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