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Oxidative stress and testosterone

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https://www.readbyqxmd.com/read/28635608/the-protective-role-of-folic-acid-against-testicular-dysfunction-in-lead-intoxicated-rat-model
#1
Asmaa Ms Gomaa, Nasser S Abou Khalil, Mohammed A Abdel-Ghani
There is an increasing concern over male reproductive toxicity caused by lead exposure. Folic acid (FA) is supposed to be a promising therapeutic strategy against lead toxicity. Therefore, the aim of this experimental study was to shed light on the potential protective role of FA on lead-induced testicular dysfunction in rats and its possible underlying mechanistic pathways. Rats (n = 24) were divided into four groups: Control, FA, Lead, and FA+Lead group. After 4 weeks, lead intoxication resulted in a marked reduction in the relative testicular weight and the serum level of testosterone, an impairment in the characters of semen analysis, and an increased content of lead, malondialdehyde and both interleukin-6 and -10 and a decreased antioxidant enzyme levels in the testicular tissue homogenate...
July 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28634006/testosterone-differentially-affects-t-cells-and-neurons-in-murine-and-human-models-of-neuroinflammation-and-neurodegeneration
#2
Megan G Massa, Christina David, Stefanie Jörg, Johannes Berg, Barbara Gisevius, Sarah Hirschberg, Ralf A Linker, Ralf Gold, Aiden Haghikia
The high female-to-male sex ratio of multiple sclerosis (MS) prevalence has continuously confounded researchers, especially in light of male patients' accelerated disease course at later stages of MS. Although multiple studies have concentrated on estrogenic mechanisms of disease modulation, fairly little attention has been paid to androgenic effects in a female system, and even fewer studies have attempted to dissociate hormonal effects on the neurodegenerative and neuroinflammatory processes of MS. Herein, we demonstrate the differential effects of hormone treatment on the acute inflammatory and chronic neurodegenerative phases of murine experimental autoimmune encephalomyelitis...
July 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28620296/testosterone-propionate-exacerbates-the-deficits-of-nigrostriatal-dopaminergic-system-and-downregulates-nrf2-expression-in-reserpine-treated-aged-male-rats
#3
Rui Cui, Yunxiao Kang, Li Wang, Shuangcheng Li, Xiaoming Ji, Wensheng Yan, Guoliang Zhang, Huixian Cui, Geming Shi
There is a controversy over the effects of testosterone supplements on dopaminergic function. Both neuroprotective and toxic effects of testosterone supplements are reported. The status of oxidative stress seems to explain the neuroprotective or toxic properties of testosterone. To determine the efficacy of testosterone supplements in different status of oxidative stress, the present studies analyzed the dopamine (DA)-related behaviors and neurochemical indices, as well as markers of nigrostriatal dopaminergic (NSDA) system in reserpine-treated aged male rats followed by testosterone propionate (TP) supplements...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28619389/the-promising-effect-of-linagliptin-and-or-indole-3-carbinol-on-experimentally-induced-polycystic-ovarian-syndrome-the-role-of-transforming-growth-factor-beta-1-oxidative-stress-and-nrf2-ho-1-pathway
#4
Ahmed M Kabel, Aisha H Al-Shehri, Rehab A Altalhi
Polycystic ovarian syndrome (PCOS) is one of the most common medical condition that leads to female infertility worldwide. The aim of this study was to assess the effect of linagliptin and/or indole-3-carbinol (I3C) on PCOS in female rats. Fifty female Wistar rats were randomly allocated into five equal groups: Control group; Letrozole induced PCOS group; Letrozole + Linagliptin group; Letrozole + I3C group and Letrozole + Linagliptin + I3C group. Body weight, body mass index, Lee index and ovarian indices were determined...
June 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28610993/effects-of-a-co-micronized-composite-containing-palmitoylethanolamide-and-polydatin-in-an-experimental-model-of-benign-prostatic-hyperplasia
#5
Marika Cordaro, Daniela Impellizzeri, Rosalba Siracusa, Enrico Gugliandolo, Roberta Fusco, Antonino Inferrera, Emanuela Esposito, Rosanna Di Paola, Salvatore Cuzzocrea
Palmitoylethanolamide (PEA), a fatty acid amide-signaling molecule has well-known anti-inflammatory and neuroprotective effects. Nevertheless, PEA does not possess the ability to prevent free radicals formation. Polydatin (PLD), a biological precursor of resveratrol, has antioxidant activity. A combination of PEA and PLD could, conceivably, have beneficial effects on oxidative stress produced by inflammatory processes. In the present study we investigated the effects of a co-micronized composite containing PEA and PLD (m(PEA/PLD)) in a model of testosterone-induced benign hyperplasia (BPH)...
June 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28594424/protective-effect-of-lycium-barbarum-polysaccharides-against-cadmium-induced-testicular-toxicity-in-male-mice
#6
Lili Zhang, Qin Li, Gaoli Zheng, Yunxiang Chen, Mincong Huang, Lijiang Zhang, Xiaoyan Lin
The present study was performed to determine whether Lycium barbarum polysaccharides (LBPs) would protect mice against cadmium (Cd)-induced testicular toxicity. Seventy-two male mice were randomly divided into six groups with twelve mice per group. Four groups were administered orally with cadmium chloride (5.0 mg per kg body weight) for 35 days and treated in combination with LBPs (0, 10.0, 33.3 or 100 mg kg(-1)) from one week before exposure to Cd until the end of the experiment. The other two groups were administered orally with vehicle or LBP (100 mg kg(-1)) only...
June 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28586512/ellagic-acid-and-rosmarinic-acid-attenuate-doxorubicin-induced-testicular-injury-in-rats
#7
Gehan S Georgy, Omar W Maher
The anticancer drug doxorubicin causes testicular toxicity as an undesirable effect. The present study was undertaken to investigate the possible protection of ellagic acid and rosmarinic acid during doxorubicin administration. For this purpose eight groups of male Sprague-Dawley rats were used (n = 10), one group received vehicle served as control, and other groups received 5 mg/kg doxorubicin twice a week for 2 weeks for a cumulative dose of 20 mg/kg, ellagic acid (10 mg/kg/day, 14 consecutive days p...
June 6, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28554727/testosterone-modulates-foxo3a-and-p53-related-genes-to-protect-c2c12-skeletal-muscle-cells-against-apoptosis
#8
Lucía Pronsato, Lorena Milanesi, Andrea Vasconsuelo, Anabela La Colla
The loss of muscle mass and strength with aging, sarcopenia, is a prevalent condition among the elderly, associated with skeletal muscle dysfunction and enhanced muscle cell apoptosis. We have previously demonstrated that testosterone protects against H2O2-induced apoptosis in C2C12 muscle cells, at different levels: morphological, biochemical and molecular. Since we have observed that testosterone reduces p-p53 and maintains the inactive state of FoxO3a transcription factor, induced by H2O2, we analyzed if the hormone was exerting its antiapoptotic effect at transcriptional level, by modulating pro and antiapoptotic genes associated to them...
May 26, 2017: Steroids
https://www.readbyqxmd.com/read/28540226/traditional-chinese-medical-therapy-for-erectile-dysfunction
#9
REVIEW
Hao Li, Hongyang Jiang, Jihong Liu
Traditional Chinese medicine (TCM), including acupuncture and Chinese herbs, is used as an alternative therapy to increase the curative effect for erectile dysfunction (ED). A large number of studies have been conducted to investigate the effect and mechanism of TCM for treating ED. The therapeutic effect of acupuncture on ED is still controversial at present. However, some Chinese herbs exhibited satisfying outcomes and they might improve erectile function by activating nitric oxide synthase (NOS)-cyclic guanosine monophosphate (cGMP) pathway, increasing cyclic adenosine monophosphate (cAMP) expression, elevating testosterone level, reducing intracellular Ca(2+) concentration, down-regulating transforming growth factor β1 (TGFβ1)/Smad2 signaling pathway, or ameliorating the oxidative stress...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28531762/high-dose-testosterone-enanthate-supplementation-boosts-oxidative-stress-but-exerts-little-effect-on-the-antioxidant-barrier-in-sedentary-adolescent-male-rat-liver
#10
Ewa Sadowska-Krępa, Barbara Kłapcińska, Sławomir Jagsz, Anna Nowara, Izabela Szołtysek-Bołdys, Małgorzata Chalimoniuk, Józef Langfort, Stanisław J Chrapusta
BACKGROUND: Anabolic-androgenic steroids abuse is on the rise among adolescent boys and young men, mostly in those seeking a 'shortcut' to an improved body image. This approach is associated with the risk of severe adverse health effects, some of which involve the liver and are linked to hepatic oxidative stress. Testosterone and its esters is a cornerstone of most anabolic-androgenic steroid stacking protocols. METHODS: We assessed and compared several hepatotoxicity and liver oxidative stress indices, as well as the contents of some components of the hepatic antioxidant barrier between sedentary adolescent male rats given a 6-week course of weekly im testosterone enanthate (TE, 8 or 80mg/kgBW/week) or vehicle (sesame oil) injections...
March 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28529127/antioxidant-peroxiredoxin-3-expression-is-regulated-by-17beta-estradiol-in-rat-white-adipose-tissue
#11
Marco Bauza-Thorbrügge, M Bel Galmés-Pascual, Miquel Sbert-Roig, J Francisco García-Palmer, Magdalena Gianotti, M Ana Proenza, Isabel Lladó
Peroxiredoxin 3 (PRX3) plays a role as a regulator of the adipocyte mitochondrial function due to its antioxidant activity. We have previously reported the existence of a sexual dimorphism in the mitochondrial oxidative stress status of many rat tissues such as white (WAT) and brown (BAT) adipose tissues. The aim was to elucidate whether sex hormones may play a role in PRX3 expression in the adipose tissues of rats. In in vivo experiments, male and female standard diet fed rats, high fat diet (HFD) fed rats and rosiglitazone-supplemented HFD (HDF+Rsg) fed rats, as well as ovariectomized (OVX) and 17beta-estradiol-supplemented OVX (OVX+E2) female rats were used...
May 18, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28503943/transcriptional-profile-of-ethylene-glycol-monomethyl-ether-induced-testicular-toxicity-in-rats
#12
Takuya Matsuyama, Koichi Yabe, Chiharu Kuwata, Kazumi Ito, Yosuke Ando, Hiroshi Iida, Kazuhiko Mori
To clarify the molecular mechanism of ethylene glycol monomethyl ether (EGME)-induced testicular toxicity, the potential for EGME-related changes in transcript levels of genes including spermatocyte-specific genes was evaluated in the testis of rats given single dosing of EGME at 200, 600, or 2000 mg/kg. Furthermore, the contribution of decreased testicular testosterone on EGME-induced spermatocyte toxicity was investigated by comparing to transcriptional profile due to a testosterone synthesis inhibitor, ketoconazole (KET), at 30 or 300 mg/kg...
May 15, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28495475/ameliorative-effects-of-achillea-millefolium-inflorescences-alcoholic-extract-against-nicotine-induced-reproductive-failure-in-rat
#13
M Hallaj Salahipour, Sh Hasanzadeh, H Malekinejad
BACKGROUND: Nicotine (Nic) is a major risk factor in the development of functional disorders of male reproductive system. Achillea millefolium; is highly regarded for medicinal activities, due to its antioxidant and anti-inflammatory properties. This study was carried out to evaluate whether Achillea millefolium (Achm) inflorescences alcoholic extract could serve as a protective agent in male reproductive male failures during Nic exposure in a rat model. METHODS: Twenty-five adult male Wistar rats were categorized into the five groups...
May 8, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28475120/protective-effect-of-fragaria-ananassa-crude-extract-on-cadmium-induced-lipid-peroxidation-antioxidant-enzymes-suppression-and-apoptosis-in-rat-testes
#14
Mohammed I Y Elmallah, Manal F Elkhadragy, Ebtesam M Al-Olayan, Ahmed E Abdel Moneim
Cadmium is a deleterious environmental pollutant that threats both animals and human health. Oxidative stress and elevated levels of reactive oxygen species (ROS) have recently been reported to be the main cause of cellular damage as a result of cadmium exposure. We investigate, here, the protective effect of strawberry crude extracts on cadmium-induced oxidative damage of testes in rats. Four groups (n = 8) of 32 adult male Wistar rats weighing 160-180 g were used. The control group received 0.9% saline solution all over the experimental period (5 days)...
May 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28473188/reproductive-toxicity-of-roundup-herbicide-exposure-in-male-albino-rat
#15
Folarin O Owagboriaye, Gabriel A Dedeke, Kehinde O Ademolu, Olarenwaju O Olujimi, Joseph S Ashidi, Aladesida A Adeyinka
The incidence of infertility in human is on the increase and the use of Roundup herbicide and presence of its residues in foodstuff is a major concern. This study therefore aim to assess the effect of Roundup on the reproductive capacity of 32 adult male albino rats randomized into 4 groups of 8 rats per group orally exposed to Roundup at 3.6mg/kg body weight(bw), 50.4mg/kgbw and 248.4mg/kgbw of glyphosate concentrations for 12 weeks while the control group was given distilled water. Serum level of reproductive hormone (testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin), oxidative stress indices in the testicular tissue, epididymal sperm morphology assessment and testicular histopathology of the rats were used as a diagnostic marker of reproductive dysfunction...
May 1, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28472913/fertility-and-sperm-quality-in-the-aging-male
#16
Susana Almeida, Luís Rato, Mário Sousa, Marco G Alves, Pedro F Oliveira
Parenthood at an older age is becoming a trend among men, especially in the most developed societies. Aging has a significant impact on male fertility. Older men exhibit notable disturbances in the reproductive axis, with steroidogenesis being impacted much more than spermatogenesis. The endocrine changes, together with morphological and functional alternations of the aging testis, result in decreased testosterone production. Nonetheless, studies are needed to scrutinize the impact of age per se versus age-induced dysfunction of the reproductive axis...
May 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28471544/neonatal-hypothyroidism-affects-testicular-glucose-homeostasis-through-increased-oxidative-stress-in-prepubertal-mice-effects-on-glut3-glut8-and-cx43
#17
D Sarkar, S K Singh
Thyroid hormones (THs) play an important role in maintaining the link between metabolism and reproduction and the altered THs status is associated with induction of oxidative stress in various organs like brain, heart, liver and testis. Further, reactive oxygen species play a pivotal role in regulation of glucose homeostasis in several organs, and glucose utilization by Leydig cells is essential for testosterone biosynthesis and thus is largely dependent on glucose transporter 8 (GLUT8). Glucose uptake by Sertoli cells is mediated through glucose transporter 3 (GLUT3) under the influence of THs to meet energy requirement of developing germ cells...
May 4, 2017: Andrology
https://www.readbyqxmd.com/read/28467669/investigation-of-the-effect-of-naringenin-on-oxidative-stress-related-alterations-in-testis-of-hydrogen-peroxide-administered-rats
#18
Zafer Sahin, Ahmet Ozkaya, Gokhan Cuce, Mirac Uckun, Ertan Yologlu
Testis tissue is prone to oxidation because its plasma membrane contains many polyunsaturated fatty acids. Naringenin is a plant-derived natural flavonoid. We investigated the possible ameliorative role of naringenin on the hydrogen peroxide (H2 O2 )-induced testicular damage in Wistar rats. Animals received 12 mg/kg H2 O2 by intraperitoneal injection, and 50 mg/kg naringenin via orogastric gavage for 4 weeks. In the H2 O2 group, the testis malondialdehyde level increased, while the amount of reduced glutathione, glutathione transferase activities, and the testis weight decreased...
May 3, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28431577/dichloroacetic-acid-induced-testicular-toxicity-in-male-rats-and-the-protective-effect-of-date-fruit-extract
#19
Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati, Lotfi Achour
BACKGROUND: The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats. METHODS: Forty-eight male Wistar rats were randomly divided into six groups of eight: group I served as the control; group II was given ADE (4 ml/kg) by gavage; groups III and IV received DCA at 0.5 and 2 g/L drinking water, respectively; and groups V and VI received DCA at 0.5 and 2 g/L drinking water, respectively, before ADE administration...
April 22, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28421826/6-gingerol-improves-testicular-function-in-mice-model-of-chronic-ulcerative-colitis
#20
E O Farombi, I A Adedara, B O Ajayi, T E Idowu, O O Eriomala, F O Akinbote
The persistent inflammation and oxidative stress at the local site in ulcerative colitis reportedly extend to the testes via systemic circulation resulting in testicular dysfunction. The influence of 6-gingerol (6G), a phenolic compound isolated from Zingiber officinale, on colitis-mediated testicular dysfunction in mice was investigated in this study. Chronic ulcerative colitis was induced in mice using 2.5% dextran sulfate sodium (DSS) in drinking water for three cycles. Each cycle consisted of 7 consecutive days of exposure to DSS-treated water followed by 14 consecutive days of normal drinking water...
January 1, 2017: Human & Experimental Toxicology
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