keyword
https://read.qxmd.com/read/38497875/effect-of-melatonin-on-reproductive-function-in-propylthiouracil-induced-hypothyroidism-in-adult-male-rats
#1
JOURNAL ARTICLE
W Ezzat, W K Abdelbasset, R S Hussien, A R Azab, A Sulieman, S Yousry
OBJECTIVE: Thyroid hormones are essential for regulating metabolism, reproduction, and growth. Hypothyroidism is connected with lower sperm count and motility, leading to male infertility. Oxidative stress is likely to be linked to this interaction. Melatonin, being known as an oxidative scavenger, may offer a feasible treatment method for reproductive dysfunction accompanying hypothyroidism in adult male rats. The purpose of this investigation was to determine the mechanism by which melatonin treatment affected spermatogenic and steroidogenic function in an experimental model-induced hypothyroidism in adult male rats...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38484789/genotoxic-and-cytotoxic-effects-of-aflatoxin-on-the-reproductive-system-focus-on-cell-cycle-dynamics-and-apoptosis-in-testicular-tissue
#2
REVIEW
Cyrus Jalili, Rahele Ranjbar Shamsi, Bita Amiri, Seyran Kakebaraie, Faramarz Jalili, Touraj Zamir Nasta
Aflatoxins (AFs) are inevitable environmental contaminants that are detrimental to human and animal health. AFs interfere with metabolic processes, metabolizing into different hydroxylated derivatives in the liver, as well as mechanistically induce ROS accumulation, S-phase arrest, DNA damage, and cell apoptosis. Chronic consumption of aflatoxin-contaminated foods can adversely affect the male reproductive system, cause testicular damage, prevent testosterone synthesis, decline sperm quality, and cause infertility...
March 12, 2024: Toxicology
https://read.qxmd.com/read/38483938/the-beneficial-effect-of-allium-cepa-bulb-extract-on-reproduction-of-rats-a-two-generation-study-on-fecundity-and-sex-hormones
#3
JOURNAL ARTICLE
Sadia Suri, Saira Saeed Khan, Sadaf Naeem, Zeb Un Nisa, Nausheen Alam, Saba Majeed, Suresh Kumar, Rafeeq Alam Khan
Allium Cepa Linn. (Onions) has extensively been used in traditional medicine, is one of the important Allium species regularly used in our daily diet, and has been the source of robust phenolic compounds. The current study is intended to evaluate the fecundity-enhancing effect of A. Cepa on the reproductive performance of two successive generations of rats; F0 and F1. A. Cepa extract was initially tested for in vitro antioxidant assay via DPPH and ROS, followed by in vivo toxicity testing. In the fecundity assessment, eighteen pairs of male and female rats (n = 36, 1:1, F0 generation) were divided into three groups and dosed with 75mg/kg and 150 mg/kg daily of A...
2024: PloS One
https://read.qxmd.com/read/38479314/polystyrene-microplastics-impair-the-functions-of-cultured-mouse-leydig-tm3-and-sertoli-tm4-cells-by-inducing-mitochondrial-endoplasmic-reticulum-damage
#4
JOURNAL ARTICLE
Giulia Grillo, Sara Falvo, Debora Latino, Gabriella Chieffi Baccari, Massimo Venditti, Maria Maddalena Di Fiore, Sergio Minucci, Alessandra Santillo
Many laboratory studies demonstrated that the exposure to microplastics causes testosterone deficiency and spermatogenic impairment in mammals; however, the mechanism underlying this process remains still unclear. In this study, we investigated the effects of polystyrene microplastics (PS-MP) on the proliferation and functionality of cultured Leydig (TM3) and Sertoli (TM4) cells, focusing on the mitochondrial compartment and its association with the endoplasmic reticulum (ER). The in vitro exposure to PS-MP caused a substantial reduction in cellular viability in TM3 and TM4 cells...
March 12, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38472840/protective-effect-of-black-rice-cyanidin-3-glucoside-on-testicular-damage-in-stz-induced-type-1-diabetic-rats
#5
JOURNAL ARTICLE
Hongxing Zheng, Yingjun Hu, Jia Zhou, Baolong Zhou, Shanshan Qi
Diabetic testicular damage is quite a common and significant complication in diabetic men, which could result in infertility. The natural fertility rate of type 1 diabetes men is only 50% because of testicular damage. This research first aimed to explore the intervention effect of C3G on testicular tissue damage induced by diabetes. Here, a streptozotocin-induced type 1 diabetic rat model was established, and then C3G was administered. After 8 weeks of C3G supplementation, the symptoms of diabetes (e.g., high blood glucose, lower body weight, polydipsia, polyphagia) were relieved, and at the same time that sperm motility and viability increased, sperm abnormality decreased in C3G-treated diabetic rats...
February 27, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38468237/effects-of-intratesticular-injection-of-hypertonic-mannitol-and-saline-on-the-quality-of-donkey-sperm-indicators-of-oxidative-stress-and-testicular-tissue-pathology
#6
JOURNAL ARTICLE
Mohammadreza Baqerkhani, Ali Soleimanzadeh, Rahim Mohammadi
OBJECTIVES: The aim of the present study was to examine donkey sperm quality after intratesticular injection of hypertonic mannitol (HM) and saline (HS). METHODS: Randomly assigned to five treatment groups were 15 adult male donkeys: (1) Control group (no treatment), (2) Surgery group (surgical castration for testosterone control), (3) NS group (normal saline intratesticular injection), (4) HS group (hypertonic saline), and (5) HM group. We injected 20 mL per testicle...
March 11, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38460407/chlorocholine-chloride-exposure-induced-spermatogenic-dysfunction-via-iron-overload-caused-by-ahr-perk-axis-dependent-ferritinophagy-activation
#7
JOURNAL ARTICLE
Wanqian Guo, Chenping Kang, Xiaoxia Wang, Haoran Zhang, Lilan Yuan, Xuetao Wei, Qianqian Xiao, Weidong Hao
Chlorocholine chloride (CCC) is a plant growth regulator used worldwide that is detectable in cereals, fruits and animal products. The health effects of CCC exposure have raised public concern. Our previous research showed that CCC exposure decreased testosterone synthesis in pubertal rats. However, little is known about whether and how pubertal CCC exposure impacts spermatogenesis. In this study, we used BALB/c mice and spermatogonia-derived GC-1 cells to examine CCC-induced spermatogenic dysfunction. In vivo, pubertal CCC exposure led to decreased testicular weight, decreased testicular germ cells and poor sperm quality...
March 8, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38458495/rats-testicular-toxicity-induced-by-bisphenol-a-is-lessened-by-crocin-via-an-antiapoptotic-mechanism-and-bumped-p-glycoprotein-expression
#8
JOURNAL ARTICLE
Hesham A El-Beshbishy, Dania S Waggas, Rabab A Ali
Bisphenol A (BPA) engenders testicular toxicity via hydroxyl free radical genesis in rat striatum and depletion of the endogenous antioxidants in the epididymal sperms. The multi-drug resistance efflux carrier; P-glycoprotein (P-gp) expel the BPA from the testis and is responsible for the testicular protection through the deactivation of numerous xenobiotics. In our study, we investigated whether the BPA-induced testicular toxicity could be circumvented through administration of an antioxidant; crocin (Cr)...
March 6, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38458071/combined-effects-of-polystyrene-nanoplastics-and-lipopolysaccharide-on-testosterone-biosynthesis-and-inflammation-in-mouse-testis
#9
JOURNAL ARTICLE
Yanli Li, Yingqi Liu, Yanhong Chen, Chenjuan Yao, Shali Yu, Jianhua Qu, Gang Chen, Haiyan Wei
Microplastics (MPs)/nanoplastics (NPs), as a source and vector of pathogenic bacteria, are widely distributed in the natural environments. Here, we investigated the combined effects of polystyrene NPs (PS-NPs) and lipopolysaccharides (LPS) on testicular function in mice for the first time. 24 male mice were randomly assigned into 4 groups, control, PS-NPs, LPS, and PS-NPs + LPS, respectively. Histological alterations of the testes were observed in mice exposed to PS-NPs, LPS or PS-NPs + LPS. Total sperm count, the levels of testosterone in plasma and testes, the expression levels of steroidogenic acute regulatory (StAR) decreased more remarkable in testes of mice treated with PS-NPs and LPS than the treatment with LPS or PS-NPs alone...
March 7, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38452966/the-preventive-effect-of-heat-killed-lactobacillus-plantarum-on-male-reproductive-toxicity-induced-by-cholestasis-in-rats
#10
JOURNAL ARTICLE
Hajar Hajian, Mitra Motallebi, Maryam Akhavan Taheri, Nejat Kheiripour, Esmat Aghadavod, Mohammad Esmaeil Shahaboddin
This study investigated the preventive effect of heat-killed Lactobacillus plantarum (L. plantarum) on cholestasis-induced male reproductive toxicity in rats. Rats were divided into control normal, sham control, bile duct ligation (BDL) control, and BDL with heat-killed L. plantarum supplementation groups. The effects on sexual hormones, testicular and epididymal histology, sperm parameters, oxidative stress markers, and inflammatory gene expression were evaluated. Compared to the BDL control group, the BDL + heat-killed L...
March 5, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38451160/aflatoxin-b1-induced-testosterone-biosynthesis-disorder-via-the-ros-ampk-signaling-pathway-in-male-mice
#11
JOURNAL ARTICLE
Wanyue Huang, Jialu Zhang, Chenjiao Miao, Huihui Ying, Xuliang Zhang, Miao Song, Yilong Cui, Xichun Wang, Yanfei Li, Ping Cheng
The worldwide prevalence of Aflatoxin B1 (AFB1 ), which contaminates feedstock and food, is on the rise. AFB1 inhibits testosterone (T) biosynthesis, but the mechanism is not yet clear. By establishing in vivo and in vitro models, this study found the number of Leydig cells (LCs), T content, and the expression of T biosynthesis key enzymes were suppressed after AFB1 treatment. AFB1 exposure also increased reactive oxygen species (ROS) and promoted mitochondrial injury and mitochondrial pathway apoptosis. Moreover, the AMPK signaling pathway was activated, and using an AMPK inhibitor relieved apoptosis and the suppressed T biosynthesis key enzymes of LCs caused by AFB1 through regulating downstream p53 and Nur77...
March 7, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38449453/effects-of-perilla-frutescens-var-acuta-in-busulfan-induced-spermatogenesis-dysfunction-mouse-model
#12
JOURNAL ARTICLE
Hyung Jong Nam, Min Jung Park, Bo Sun Joo, Yean Kyoung Koo, SukJin Kim, Sang Don Lee, Hyun Jun Park
PURPOSE: The leaves of Perilla frutescens var. acuta (PFA) are generally reported to have antioxidant, anti-allergic, anti-inflammatory, and antitumor effects and commonly used as a traditional medicine in East Asia. This study aimed to investigate the protective effect and antioxidant activity of PFA on busulfan-induced testicular dysfunction, histological damage, oxidative stress (OS), sperm quality, and hormone levels using a mouse model. MATERIALS AND METHODS: C57BL/6 male mice were divided into four groups: control, busulfan-only treated, and varying concentrations of PFA (100 and 200 mg/kg) with busulfan...
February 14, 2024: World Journal of Men's Health
https://read.qxmd.com/read/38440074/melatonin-alleviates-oxidative-stress-damage-in-mouse-testes-induced-by-bisphenol-a
#13
JOURNAL ARTICLE
Qi Qi, Jiaxin Yang, Shuang Li, Jingjing Liu, Da Xu, Guoqing Wang, Lei Feng, Xiaoyan Pan
We investigated the effect of melatonin on bisphenol A (BPA)-induced oxidative stress damage in testicular tissue and Leydig cells. Mice were gavaged with 50 mg/kg BPA for 30 days, and concurrently, were injected with melatonin (10 mg/kg and 20 mg/kg). Leydig cells were treated with 10 μmol/L of BPA and melatonin. The morphology and organ index of the testis and epididymis were observed and calculated. The sperm viability and density were determined. The expressions of melatonin receptor 1A and luteinizing hormone receptor, and the levels of malonaldehyde, antioxidant enzymes, glutathione, steroid hormone synthases, aromatase, luteinizing hormone, testosterone, and estradiol were measured...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38439912/single-cell-transcriptome-profiling-implicates-the-psychological-stress-induced-disruption-of-spermatogenesis
#14
JOURNAL ARTICLE
Rufeng Li, Yuefeng Du, Kang Li, Xiaofan Xiong, Lingyu Zhang, Chen Guo, Shanfeng Gao, Yufei Yao, Yungang Xu, Juan Yang
Male infertility has emerged as a global issue, partly attributed to psychological stress. However, the cellular and molecular mechanisms underlying the adverse effects of psychological stress on male reproductive function remain elusive. We created a psychologically stressed model using terrified-sound and profiled the testes from stressed and control rats using single-cell RNA sequencing. Comparative and comprehensive transcriptome analyses of 11,744 testicular cells depicted the cellular landscape of spermatogenesis and revealed significant molecular alterations of spermatogenesis suffering from psychological stress...
March 12, 2024: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/38433013/caffeine-attenuates-spermatogenic-disorders-in-mice-with-induced-chronic-scrotal-hyperthermia
#15
JOURNAL ARTICLE
Amir Raoofi, Omid Gholami, Hossein Mokhtari, Fatemeh Bagheri, Auob Rustamzadeh, Davood Nasiry, Alireza Ghaemi
OBJECTIVE: Chronic scrotal hyperthermia (SHT) can lead to serious disorders of the male reproductive system, with oxidative stress playing a key role in the onset of these dysfunctions. Thus, we evaluated the impact of caffeine, a potent antioxidant, on cellular and tissue disorders in mice with chronic SHT. METHODS: In this experimental study, 56 adult male NMRI mice were allocated into seven equal groups. Apart from the non-treated control group, all were exposed to heat stress...
March 2024: Clinical and Experimental Reproductive Medicine
https://read.qxmd.com/read/38430634/a-multi-modal-approach-to-investigate-desmodium-gangeticum-s-influence-on-stress-induced-male-infertility-in-vivo-in-vitro-and-in-silico-assessments
#16
JOURNAL ARTICLE
Yahya S Alqahtani, Vijay R Chidrawar, Shruti Shiromwar, Sudarshan Singh, Rahul Maheshwari, Havagiray Chitme, Naresh Babu Chilamakuru, Popat Mohite, Ahmed M Aljameeli, Masood Medleri Khateeb
Physical and psychological stress has an inverse relation with male libido and sperm quality. The present study investigates the potential fertility-enhancing properties of Desmodium gangeticum (DG) root extracts in male Wister rats subjected to immobilization-induced stress (SIMB). DG roots were extracted using n-hexane (HEDG), chloroform (CEDG), and water (AEDG). In the pilot study, aphrodisiac protentional was investigated at two doses (125 and 250 mg kg-1 ) of each extract. In the main study, the HEDG and AEDG at 125 and 250 mg kg-1 were challenged for the stress by immobilization (SIMB), for 6 h daily over 28 days...
March 1, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38402776/influence-of-photoperiod-and-exogenous-melatonin-on-testis-morpho-physiology-of-sexually-mature-guinea-fowl-numida-meleagris
#17
JOURNAL ARTICLE
Innocent J Gosomji, Umar M Bello, Tavershima Dzenda, Abdullahi Baso, Augustine Arukwe, Tom A Aire
The biological effects of simulated photoperiod and melatonin on the control of reproduction of guinea fowls (Numida meleagris) are not well understood. Herein, thirty (30) sexually mature guinea fowl cocks were randomly assigned to 1-6 groups (n = 5) and subjected to different photoperiodic regimes in the presence or absence of exogenous melatonin (Mel; 1 BW/day, i/m) for eight weeks. Testes of the euthanized cocks were processed for gross morphology, histological, histochemical, and oxidative stress markers...
January 10, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38397771/male-reproductive-toxicity-of-antifouling-chemicals-insights-into-oxidative-stress-induced-infertility-and-molecular-mechanisms-of-zinc-pyrithione-zpt
#18
REVIEW
Mogellah John Panga, Ye Zhao
Zinc pyrithione (ZPT), a widely utilized industrial chemical, is recognized for its versatile properties, including antimicrobial, antibacterial, antifungal, and antifouling activities. Despite its widespread use, recent research has shed light on its toxicity, particularly towards the male reproductive system. While investigations into ZPT's impact on male reproduction have been conducted, most of the attention has been directed towards marine organisms. Notably, ZPT has been identified as a catalyst for oxidative stress, contributing to various indicators of male infertility, such as a reduced sperm count, impaired sperm motility, diminished testosterone levels, apoptosis, and degenerative changes in the testicular tissue...
January 29, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38388241/associations-of-urinary-total-arsenic-and-arsenic-species-and-periodontitis
#19
JOURNAL ARTICLE
Han Yang, Jing Wang, Qiansi Chen, Yuxuan Wu, Yuying Wu, Qingrong Deng, Yiming Yu, Fuhua Yan, Yanfen Li, Baochang He, Fa Chen
AIMS: Arsenic exposure is a significant global public health concern and has been implicated in endocrine disruption and increased oxidative stress, both of which are crucial pathogenic mechanisms of periodontitis. This study aimed to investigate the association of urinary total arsenic and arsenic species with periodontitis and to further explore the potential mediating roles of sex hormones and oxidative stress indicators. METHODS: Data used in this study were derived from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) in the US population...
February 21, 2024: International Dental Journal
https://read.qxmd.com/read/38387328/kaempferol-alleviates-bisphenol-a-reproductive-toxicity-in-rats-in-a-dose-dependent-manner
#20
JOURNAL ARTICLE
Inas Molayousefian, Bardia Karim, Seyed Mohammad Hosseini, Ali Akbar Moghadamnia, Sohrab Kazemi
BACKGROUND: Endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA), are a major cause of male infertility by disrupting spermatogenesis. OBJECTIVE: Here, we examined the potential protective benefits of kaempferol (KMF), a flavonol known for its antioxidant properties, on BPA-induced reproductive toxicity in adult male rats. METHODS: Human skin fibroblast cells (HNFF-P18) underwent cell viability assays. Thirty-five male Wistar rats were assigned to four groups: 1) control, 2) BPA (10 mg/kg), 3,4) BPA, and different dosages of KMF (1 and 10 mg/kg)...
February 13, 2024: Biochemical and Biophysical Research Communications
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