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Oxidative stress and testosterone

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https://www.readbyqxmd.com/read/28431577/dichloroacetic-acid-induced-testicular-toxicity-in-male-rats-and-the-protective-effect-of-date-fruit-extract
#1
Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati, Lotfi Achour
BACKGROUND: The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats. METHODS: Forty-eight male Wistar rats were randomly divided into six groups of eight: group I served as the control; group II was given ADE (4 ml/kg) by gavage; groups III and IV received DCA at 0.5 and 2 g/L drinking water, respectively; and groups V and VI received DCA at 0.5 and 2 g/L drinking water, respectively, before ADE administration...
April 22, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28421826/6-gingerol-improves-testicular-function-in-mice-model-of-chronic-ulcerative-colitis
#2
E O Farombi, I A Adedara, B O Ajayi, T E Idowu, O O Eriomala, F O Akinbote
The persistent inflammation and oxidative stress at the local site in ulcerative colitis reportedly extend to the testes via systemic circulation resulting in testicular dysfunction. The influence of 6-gingerol (6G), a phenolic compound isolated from Zingiber officinale, on colitis-mediated testicular dysfunction in mice was investigated in this study. Chronic ulcerative colitis was induced in mice using 2.5% dextran sulfate sodium (DSS) in drinking water for three cycles. Each cycle consisted of 7 consecutive days of exposure to DSS-treated water followed by 14 consecutive days of normal drinking water...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28420996/chronic-water-pipe-smoke-exposure-induces-injurious-effects-to-reproductive-system-in-male-mice
#3
Badreldin H Ali, Khalid A Al Balushi, Mohammed Ashique, Asem Shalaby, Mohammed A Al Kindi, Sirin A Adham, Turan Karaca, Sumaya Beegam, Priya Yuvaraju, Abderrahim Nemmar
There is a global increase in the popularity of water-pipe tobacco smoking including in Europe and North America. Nevertheless, little is known about the male reproductive effects of water-pipe smoke (WPS), especially after long-term exposure. Here, we assessed effects of WPS exposure (30 min/day) in male mice for 6 months. Control mice were exposed to air-only for the same period of time. Twenty-four hours after the last exposure, testicular histopathology, and markers of inflammation and oxidative stress, and the tyrosine-protein kinase vascular endothelial growth factor receptor 1 (VEGFR1) were assessed in testicular homogenates...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28419133/reproductive-toxicity-after-levetiracetam-administration-in-male-rats-evidence-for-role-of-hormonal-status-and-oxidative-stress
#4
Merve Baysal, Sinem Ilgin, Gozde Kilic, Volkan Kilic, Seyda Ucarcan, Ozlem Atli
Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of this drug on the male reproductive system, as it is commonly used in male patients of reproductive age. From this point of view, our aim was to evaluate the possible toxic effects of LEV on the male reproductive system. Therefore, LEV was administered to male rats orally at 50, 150, and 300 mg/kg for 70 consecutive days...
2017: PloS One
https://www.readbyqxmd.com/read/28413915/oxidative-stress-status-in-congenital-hypogonadism-an-appraisal
#5
C Haymana, A Aydoğdu, B Soykut, O Erdem, T Ibrahimov, M Dinc, C Meric, Y Basaran, A Sonmez, O Azal
Patients with hypogonadism are at increased risk of cardiac and metabolic diseases. However, the pathogenesis of increased cardiometabolic risk in patients with hypogonadism is not clear. Oxidative stress plays an important role in the pathogenesis of cardiometabolic diseases. This study aimed to investigate possible differences in oxidative stress conditions between patients with hypogonadism and healthy controls. In this study, 38 male patients with congenital hypogonadotrophic hypogonadism (CHH) (mean age: 21...
April 16, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28398617/citalopram-induces-reproductive-toxicity-in-male-rats
#6
Sinem Ilgin, Gozde Kilic, Merve Baysal, Volkan Kilic, Busra Korkut, Seyda Ucarcan, Ozlem Atli
BACKGROUND: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects of CTL on the reproductive system of male rats. METHODS: For this purpose, CTL was administered at 5, 10, and 20 mg/kg/day to rats orally for 28 days. Sperm concentration, motility, and morphology were investigated using a computer-assisted sperm analysis system, and sperm DNA damage was detected using a Comet assay...
April 17, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28395332/acetamiprid-inhibits-testosterone-synthesis-by-affecting-the-mitochondrial-function-and-cytoplasmic-adenosine-triphosphate-production-in-rat-leydig-cells%C3%A2
#7
Deying Kong, Jidong Zhang, Xiaohui Hou, Shibin Zhang, Jun Tan, Yuanshou Chen, Weirong Yang, Junwei Zeng, Yong Han, Xiaohong Liu, Delin Xu, Renlian Cai
The insecticide acetamiprid is used to control noxious agricultural pests. However, it can cause mammalian toxicity. We evaluated the reproductive toxicity of acetamiprid in adult male Sprague Dawley rats. Rats were given oral acetamiprid alone or with vitamin E for 35 days. Rat plasma testosterone concentration and sperm quality decreased significantly as the levels of luteinizing hormone (LH) increased after exposure. At the same time, acetamiprid increased malondialdehyde and nitric oxide (NO) levels of Leydig cells...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28390404/increase-of-glutathione-testosterone-and-antioxidant-effects-of-jurenia-dolomiaea-on-ccl4-induced-testicular-toxicity-in-rat
#8
Naseer Ali Shah, Muhammad Rashid Khan
BACKGROUND: Root of Jurenia dolomiaea is used traditionally in various disorders involving oxidative injuries i.e. rheumatism, gout and as stimulant. Earlier we have investigated in vitro antioxidant and DNA protective ability. In this investigation we have evaluated protective potential of J. dolomiaea root against the oxidative injuries induced with carbon tetrachloride (CCl4) in testes of rat. METHODS: Dried roots of J. dolomiaea were powdered and extracted with 95% methanol and residue was fractionated in escalating polarity of solvents...
April 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28386349/pyrroloquinoline-quinone-prevents-testosterone-deficiency-induced-osteoporosis-by-stimulating-osteoblastic-bone-formation-and-inhibiting-osteoclastic-bone-resorption
#9
Xuan Wu, Jie Li, Hengwei Zhang, Hui Wang, Guoyong Yin, Dengshun Miao
Accumulating evidences suggest that oxidative stress caused and deteriorated the aging related osteoporosis and pyrroloquinoline quinone (PQQ) is a powerful antioxidant. However, it is unclear whether PQQ can prevent testosterone deficiency-induced osteoporosis. In this study, the orchidectomized (ORX) mice were supplemented in diet with/without PQQ for 48 weeks, and compared with each other and with sham mice. Results showed that bone mineral density, trabecular bone volume, collagen deposition and osteoblast number were decreased significantly in ORX mice compared with shame mice, whereas PQQ supplementation largely prevented these alterations...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28384430/low-doses-of-bisphenol-a-can-impair-postnatal-testicular-development-directly-without-affecting-hormonal-or-oxidative-stress-levels
#10
Fernanda M Ogo, Glaucia E M L Siervo, Géssica D Gonçalves, Rubens Cecchini, Flavia A Guarnier, Janete Ap Anselmo-Franci, Glaura S A Fernandes
Bisphenol A (BPA) is considered a potent endocrine disruptor, causing changes in the endocrine system due to its oestrogenic activity. Male individuals may be susceptible to endocrine, morphological and physiological alterations during testicular postnatal development. The aim of the present study was to evaluate whether exposure to BPA during the peripubertal period can damage testicular development. To this end, male Wistar rats were treated with BPA via gavage at doses of 20 or 200µgkg-1 on Postnatal Days (PND) 36-66...
April 7, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28361573/effects-of-time-of-day-on-oxidative-stress-cardiovascular-parameters-biochemical-markers-and-hormonal-response-following-level-1-yo-yo-intermittent-recovery-test
#11
K Aloui, S Abedelmalek, H Chtourou, D P Wong, N Boussetta, N Souissi
The aim of this study was to investigate the effect of time-of-day on oxidative stress, cardiovascular parameters, muscle damage parameters, and hormonal responses following the level-1 Yo-Yo intermittent recovery test (YYIRT). A total of 11 healthy subjects performed an intermittent test (YYIRT) at two times-of-day (i.e., 07:00 h and 17:00 h), with a recovery period of ≥36 h in-between, in a randomized order. Blood samples were taken at the rest (baseline) and immediately (post-YYIRT) after the YYIRT for measuring oxidative stress, biochemical markers, and hormonal response...
March 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28359952/low-testosterone-levels-are-related-to-oxidative-stress-mitochondrial-dysfunction-and-altered-subclinical-atherosclerotic-markers-in-type-2-diabetic-male-patients
#12
Susana Rovira-Llopis, Celia Bañuls, Aranzazu M de Marañon, Noelia Diaz-Morales, Ana Jover, Sandra Garzon, Milagros Rocha, Victor M Victor, Antonio Hernandez-Mijares
INTRODUCTION: Low testosterone levels in men are associated with type 2 diabetes and cardiovascular risk. However, the role of testosterone in mitochondrial function and leukocyte-endothelium interactions is unknown. Our aim was to evaluate the relationship between testosterone levels, metabolic parameters, oxidative stress, mitochondrial function, inflammation and leukocyte-endothelium interactions in type 2 diabetic patients. MATERIALS AND METHODS: The study was performed in 280 male type 2 diabetic patients and 50 control subjects...
March 27, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28349382/protective-effect-of-selenium-on-aflatoxin-b1-induced-testicular-toxicity-in-mice
#13
Zheng Cao, Bing Shao, Feibo Xu, Yunfeng Liu, Yanfei Li, Yanzhu Zhu
Aflatoxins have been considered as one of the major risk factors of male infertility, and aflatoxin B1 (AFB1) is the most highly toxic and prevalent member of the aflatoxins family. Selenium (Se), an essential nutritional trace mineral for normal testicular development and male fertility, has received extensive intensive on protective effects of male reproductive system due to its potential antioxidant and activating testosterone synthesis. To investigate the protective effect of Se on AFB1-induced testicular toxicity, the mice were orally administered with AFB1 (0...
March 27, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28342008/alterations-of-the-oxidative-status-in-rat-hippocampus-and-prodepressant-effect-of-chronic-testosterone-enanthate-administration
#14
Jovana Joksimović, Dragica Selaković, Vladimir Jakovljević, Vladimir Mihailović, Jelena Katanić, Tatjana Boroja, Gvozden Rosić
In a last few decades, anabolic-androgenic steroids (AASs) abuse has become serious health concern especially among adolescents. AASs abuse has been reported to be involved in pathogenesis of various mood disorders, including depression. In order to evaluate the effects of chronic (6 weeks) testosterone enanthate (TE) treatment in supraphysiological dose and exercise on depression-like behavior in rats, 32 male rats were divided into four groups: control (C), testosterone enanthate (T, 20 mg/kg/w, s.c.), exercise (E, swimming for 1 h/day), and combined group-testosterone enanthate plus exercise (T + E)...
March 24, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28336198/augmented-oxidative-stress-in-infertile-women-with-persistent-chlamydial-infection
#15
Jelena Tošić-Pajić, Dragana Šeklić, Jelena Radenković, Snežana Marković, Jelena Čukić, Dejan Baskić, Suzana Popović, Milos Todorovic, Predrag Sazdanović
There is established association between oxidative stress, infections of genital tract and fertility. Genital tract infections may provoke increased production of free radicals and generate oxidative stress that can be involved in pathophysiology of a number of reproductive diseases and complications during pregnancy. The aim of this study was to determine connection between oxidative stress and infertility associated with persistent chlamydial infection. Serum samples of infertile women with tubal factor infertility (TFI), women with multiple spontaneous abortions (MSA) and fertile women was screened for C...
March 20, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28295950/sulforaphane-attenuates-di-n-butylphthalate-induced-reproductive-damage-in-pubertal-mice-involvement-of-the-nrf2-antioxidant-system
#16
Xu-Ping Jiang, Jing-Yuan Tang, Zhen Xu, Peng Han, Zhi-Qiang Qin, Cheng-di Yang, Shang-Qian Wang, Min Tang, Wei Wang, Chao Qin, Yang Xu, Bai-Xin Shen, Wei-Min Zhou, Wei Zhang
di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially the male reproductive system. Here, we investigated the effects of DBP on the male reproductive system of pubertal mice and explored the protective role of sulforaphane (SFN). The results showed that DBP significantly reduced the anogenital distance, testicular weight, sperm count and motility, and plasma and testicular testosterone levels and significantly increased the oxidative stress, sperm abnormalities, and testicular cell apoptosis...
March 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28295462/ferulic-acid-prevents-lead-induced-testicular-oxidative-stress-and-suppressed-spermatogenesis-in-rats
#17
P Hasanein, F Fazeli, M Parviz, M Roghani
Lead affects multiple organ systems including testis. We investigated the effects of ferulic acid (FA) on lead-induced oxidative stress and spermatogenesis suppression in rats. Animals received lead acetate (500 mg/L in drinking water) and/or FA (50 mg/kg, i.g.) for eight weeks. Lead increased testicular malondialdehyde (MDA) and nitrite levels and decreased glutathione (GSH) content and catalase (CAT) activity. Lead decreased testis weight and testosterone level. Sperm parameters decreased in lead group...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28285354/endocrine-disruption-oxidative-stress-and-testicular-damage-induced-by-4-nonylphenol-in-clarias-gariepinus-the-protective-role-of-cydonia-oblonga
#18
Alaa El-Din H Sayed, Rania F K Ismail
Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (Cydonia oblonga). To fulfill this aim, catfish Clarias gariepinus were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17ß-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level...
March 11, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28277426/effect-of-cold-water-immersion-performed-on-successive-days-on-physical-performance-muscle-damage-and-inflammatory-hormonal-and-oxidative-stress-markers-in-volleyball-players
#19
Victor H de Freitas, Solange P Ramos, Maurício G Bara-Filho, Daniel G S Freitas, Danilo R Coimbra, Rubens Cecchini, Flávia A Guarnier, Fábio Y Nakamura
The aim of this study was to investigate the effects of daily cold water immersion (CWI) on physical performance, muscle damage, and inflammatory, hormonal, and oxidative stress markers in volleyball. Six players were submitted to CWI and six players to a placebo, during 5 training days. Thigh circumference, squat jump, and agility were measured on the 1, 3 and 6 days. On the 1 and 6 days, blood and saliva were collected for analysis of oxidative stress, muscle damage, and inflammatory and hormonal levels. Muscle soreness and countermovement jump were quantified daily...
March 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28261838/radiofrequency-electromagnetic-radiation-from-cell-phone-causes-defective-testicular-function-in-male-wistar-rats
#20
A O Oyewopo, S K Olaniyi, C I Oyewopo, A T Jimoh
Cell phones have become an integral part of everyday life. As cell phone usage has become more widespread, concerns have increased regarding the harmful effects of radiofrequency electromagnetic radiation from these devices. The current study was undertaken to investigate the effects of the emitted radiation by cell phones on testicular histomorphometry and biochemical analyses. Adult male Wistar rats weighing 180-200 g were randomly allotted to control, group A (switched off mode exposure), group B (1-hr exposure), group C (2-hr exposure) and group D (3-hr exposure)...
March 6, 2017: Andrologia
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