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https://www.readbyqxmd.com/read/28945005/differential-expression-of-myometrial-ap-1-proteins-during-gestation-and-labour
#1
Lubna Nadeem, Tali Farine, Anna Dorogin, Elzbieta Matysiak-Zablocki, Oksana Shynlova, Stephen Lye
Preterm labour (PTL) is a leading cause of perinatal mortality and postnatal morbidity. Contractions of the uterine muscle (myometrium) that determine the onset of labour depend on the expression of contraction-associated proteins (CAPs, i.e. connexin43) regulated by dimeric AP-1 transcription factors. Here, we examined subcellular (by immunoblotting) and tissue expression (by immunohistochemistry) of myometrial AP-1 proteins (cJUN, JUNB, JUND, cFOS, FOSB, FRA1, FRA2) throughout gestation and TL in different species (mouse, rat and human)...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28943342/mechanisms-of-platelet-activation-by-the-pneumococcus-and-the-role-of-platelets-in-community-acquired-pneumonia
#2
REVIEW
Ronald Anderson, Charles Feldman
There is increasing recognition of the involvement of platelets in orchestrating inflammatory responses, driving the activation of neutrophils, monocytes and vascular endothelium, which, if poorly controlled, may lead to microvascular dysfunction. Importantly, hyperreactivity of platelets has been implicated in the pathogenesis of myocardial injury and the associated particularly high prevalence of acute cardiovascular events in patients with severe community-acquired pneumonia (CAP), of which Streptococcus pneumoniae (pneumococcus) is the most commonly encountered aetiologic agent...
September 21, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28943340/decoupling-brain-from-nerve-cord-development-in-the-annelid-capitella-teleta-insights-into-the-evolution-of-nervous-systems
#3
Allan M Carrillo-Baltodano, Néva P Meyer
In the deuterostomes and ecdysozoans that have been studied (e.g. chordates and insects), neural fate specification relies on signaling from surrounding cells. However, very little is known about mechanisms of neural specification in the third major bilaterian clade, spiralians. Using blastomere isolation in the annelid Capitella teleta, a spiralian, we studied to what extent extrinsic versus intrinsic signals are involved in early neural specification of the brain and ventral nerve cord. For the first time in any bilaterian, we found that brain neural ectoderm is autonomously specified...
September 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28943315/nlrp3-phosphorylation-is-an-essential-priming-event-for-inflammasome-activation
#4
Nan Song, Zhao-Shan Liu, Wen Xue, Zhao-Fang Bai, Qian-Yi Wang, Jiang Dai, Xin Liu, Yi-Jiao Huang, Hong Cai, Xiao-Yan Zhan, Qiu-Ying Han, Hongxia Wang, Yuan Chen, Hui-Yan Li, Ai-Ling Li, Xue-Min Zhang, Tao Zhou, Tao Li
Many infections and stress signals can rapidly activate the NLRP3 inflammasome to elicit robust inflammatory responses. This activation requires a priming step, which is thought to be mainly for upregulating NLRP3 transcription. However, recent studies report that the NLRP3 inflammasome can be activated independently of transcription, suggesting that the priming process has unknown essential regulatory steps. Here, we report that JNK1-mediated NLRP3 phosphorylation at S194 is a critical priming event and is essential for NLRP3 inflammasome activation...
September 19, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28943175/a-promising-new-test-to-detect-streptococcus-pneumoniae-urinary-antigen
#5
C Loïez, C Duployez, F Wallet
BACKGROUND: Streptococcus pneumoniae is the main etiology of community-acquired pneumonia (CAP). A quick detection of urinary antigen helps in obtaining a documented result in case of Streptococcus pneumoniae CAP. METHODS: We compared the BinaxNOW(®)S. pneumoniae test with the new urinary antigen Sofia(®)S. pneumoniae FIA. We examined 133 urine samples. RESULTS: Of the 133 included and tested non-concentrated urine samples, BinaxNOW(®) and Sofia(®) tests yielded 122 and 113 negative results and 11 and 20 positive results, respectively...
September 21, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28942518/projecting-the-potential-impact-of-the-cap-score%C3%A2-on-clinical-pregnancy-live-births-and-medical-costs-in-couples-with-unexplained-infertility
#6
Joseph B Babigumira, Fady I Sharara, Louis P Garrison
PURPOSE: The Cap-Score™ was developed to assess the capacitation status of men, thereby enabling personalized management of unexplained infertility by choosing timed intrauterine insemination (IUI), versus immediate in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in individuals with a low Cap-Score™. The objective of this study was to estimate the differences in outcomes and costs comparing the use of the Cap-Score™ with timed IUI (CS-TI) and the standard of care (SOC), which was assumed to be three IUI cycles followed by three IVF-ICSI cycles...
September 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28942425/chromosome-healing-is-promoted-by-the-telomere-cap-component-hiphop-in-drosophila
#7
Rebeccah L Kurzhals, Laura Fanti, A C Gonzalez Ebsen, Yikang S Rong, Sergio Pimpinelli, Kent G Golic
The addition of a new telomere onto a chromosome break, a process termed healing, has been studied extensively in organisms that utilize telomerase to maintain their telomeres. In comparison, relatively little is known about how new telomeres are constructed on broken chromosomes in organisms that do not use telomerase. Chromosome healing was studied in somatic and germline cells of Drosophila melanogaster, a non-telomerase species. We observed, for the first time, that broken chromosomes can be healed in somatic cells...
September 23, 2017: Genetics
https://www.readbyqxmd.com/read/28941917/national-trends-in-the-management-of-primary-vesicoureteral-reflux-in-children
#8
Michael Garcia-Roig, Curtis Tavers, Courtney E McCracken, Andrew J Kirsch
OBJECTIVE: In September 2011, the American Academy of Pediatrics(AAP) released updated guidelines for workup of children 2-24 months old with a febrile urinary tract infection(UTI). We aimed to document the guideline's impact on diagnosis and surgical management of VUR at US children's hospitals. We hypothesize that VCUG studies and VUR treatment rate decreased concurrent with national guideline release. METHODS: The Pediatric Health Information System(PHIS) was queried for children(<18 years) with primary VUR, and their anti-reflux surgical history, from January 2004-June 2015...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941777/new-pyrimidine-based-ligand-capped-gold-and-platinum-nano-particles-synthesis-characterization-antimicrobial-antioxidant-dna-interaction-and-in-vitro-anticancer-activities
#9
M Sankarganesh, P Adwin Jose, J Dhaveethu Raja, M P Kesavan, M Vadivel, J Rajesh, R Jeyamurugan, R Senthil Kumar, S Karthikeyan
In this research work, we have synthesized new pyrimidine based Schiff base ligand, 2-((4,6-dimethoxypyrimidine-2-yl)methyleneenamino)-6-methoxyphenol (DPMM) capped gold (Au) and platinum (Pt) nanoparticles (NPs) by modified Brust-Schiffrin method. The characteristics of DPMM-Au NPs and DPMM-Pt NPs have been examined by UV-Visible, FTIR, SEM, TEM and powder XRD analysis. SEM analysis result shows that surface morphology of the DPMM-Au NPs and DPMM-Pt NPs are in granular and spherical shape, correspondingly...
September 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28941403/dual-function-of-a-cis-acting-rna-element-that-acts-as-a-replication-enhancer-and-a-translation-repressor-in-a-plant-positive-stranded-rna-virus
#10
Kiwamu Hyodo, Hikari Nagai, Tetsuro Okuno
The genome of red clover necrotic mosaic virus is divided into two positive-stranded RNA molecules of RNA1 and RNA2, which have no 5' cap structure and no 3' poly(A) tail. Previously, we showed that any mutations in the cis-acting RNA replication elements of RNA2 abolished its cap-independent translational activity, suggesting a strong link between RNA replication and translation. Here, we investigated the functions of the 5' untranslated region (UTR) of RNA2 and revealed that the basal stem-structure (5'BS) predicted in the 5' UTR is essential for robust RNA replication...
September 20, 2017: Virology
https://www.readbyqxmd.com/read/28941199/capped-mesoporous-silica-nanoparticles-for-the-selective-and-sensitive-detection-of-cyanide
#11
Sameh El Sayed, Maurizio Licchelli, Ramón Martínez-Máñez, Félix Sancenón
The development of easy and affordable methods for the detection of cyanide is of great significance due to the high toxicity of this anion and the potential risks associated with its pollution. Herein, optical detection of cyanide in water has been achieved by using a hybrid organic-inorganic nanomaterial. Mesoporous silica nanoparticles were loaded with [Ru(bipy)3 ](2+) , functionalized with macrocyclic nickel(II) complex subunits, and capped with a sterically hindering anion (hexametaphosphate). Cyanide selectively induces demetallation of nickel(II) complexes and the removal of capping anions from the silica surface, allowing the release of the dye and the consequent increase in fluorescence intensity...
September 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28941182/enhanced-wound-healing-performance-of%C3%A2-a%C3%A2-phyto-polysaccharide-enriched-dressing%C3%A2-%C3%A2-a-preclinical-small-and-large-animal-study
#12
Chih-Hsin Wang, Shu-Jen Chang, Yuan-Sheng Tzeng, Yu-Jen Shih, Chang Adrienne, Shyi-Gen Chen, Tim-Mo Chen, Niann-Tzyy Dai, Juin-Hong Cherng
Alginate is a natural rich anionic polysaccharide (APS), commonly available as calcium alginate (CAPS). It can maintain a physiologically moist microenvironment, which minimises bacterial infection and facilitates wound healing at a wound site. Patients with burn injuries suffer from pain and an inflammatory response. In this study, we evaluated the CAPS dressing and traditional dressing containing carboxymethyl cellulose (CMC) for wound healing and scar tissue formation in a burn model of rat and swine. In our pilot study of a burn rat model to evaluate inflammatory response and wound healing, we found that the monocyte chemoattractant protein (MCP)-1 and transforming growth factor (TGF)-β were up-regulated in the CAPS treatment group...
September 21, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28941180/reactive-electrophilic-oi-species-evidenced-in-high-performance-ir-oxohydroxide-water-oxidation-electrocatalysts
#13
Cyriac Massué, Verena Pfeifer, Maurice Van Gastel, Johannes Noack, Gerardo Algara-Siller, Sebastien Cap, Robert Schlögl
Although quasi-amorphous Ir-oxohydroxides have repeatedly been identified as superior oxygen evolution reaction (OER) electrocatalysts, an exact description of the performance relevant species has so far remained a challenge. In this context, we report on the characterization of hydrothermally prepared IrIII/IV oxohydroxides exhibiting exceptional OER-performance. It was found that holes in the O2p states of IrIII/IV-oxohydroxides result in reactive OI--species identified by characteristic NEXAFS-features. A prototypical titration reaction based on CO as a probe molecule shows that these OI--species are highly susceptible to nucleophilic attack at room temperature...
September 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28940824/clinical-implications-of-controlled-attenuation-parameter-in-a-health-check-up-cohort
#14
Min-Sun Kwak, Goh Eun Chung, Jong In Yang, Jeong Yoon Yim, Su Jin Chung, Se Young Jung, Joo Sung Kim
BACKGROUND & AIMS: Evaluation of the controlled attenuation parameter (CAP) is a promising noninvasive method for assessing hepatic steatosis. Despite the increasing reliability of the CAP for assessing steatosis in subjects with chronic liver disease, few studies have evaluated the CAP in asymptomatic subjects without overt liver disease. Therefore, we aimed to evaluate the usefulness of the CAP for a health check-up population. METHODS: We enrolled subjects who underwent abdominal ultrasonography (US), FibroScan (Echosens, France) and blood sampling during medical health check-ups...
September 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28940759/the-bottle-gourd-genome-provides-insights-into-cucurbitaceae-evolution-and-facilitates-mapping-of-a-papaya-ringspot-virus-resistance-locus
#15
Shan Wu, Md Shamimuzzaman, Honghe Sun, Jerome Salse, Xuelian Sui, Alan Wilder, Zujian Wu, Amnon Levi, Yong Xu, Kai-Shu Ling, Zhangjun Fei
Bottle gourd (Lagenaria siceraria) is an important vegetable crop as well as a rootstock for other cucurbit crops. In this study, we report a high-quality 313.4-Mb genome sequence of a bottle gourd inbred line, USVL1VR-Ls, with a scaffold N50 of 8.7 Mb and the longest of 19.0 Mb. About 98.3% of the assembled scaffolds are anchored to the 11 pseudomolecules. Our comparative genomic analysis identifies chromosome-level syntenic relationships between bottle gourd and other cucurbits, as well as lineage-specific gene family expansions in bottle gourd...
September 23, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28940421/changes-in-pulmonary-artery-systolic-pressure-correlate-with-radiographic-severity-and-peripheral-oxygenation-in-adults-with-community-acquired-pneumonia
#16
Katherina Bernadette Sreter, Ivan Budimir, Andrija Golub, Zdravko Dorosulić, Mateja Sabol Pušić, Marko Boban
PURPOSE: The aim of this prospective observational study was to evaluate the relationship between changes in pulmonary artery systolic pressure (ΔPASP) and both severity of community-acquired pneumonia (CAP) and changes in peripheral blood oxygen partial pressure (PaO2 ). MATERIALS AND METHODS: Seventy-five consecutive adult patients hospitalized for treatment of CAP were recruited in this single-center cohort study. Doppler echocardiographic measurement of PASP was performed by 2 staff cardiologists...
September 22, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28939719/clinical-characteristics-and-management-of-coronary-artery-perforations-a-single-center-11-year-experience-and-practical-overview
#17
Miguel E Lemmert, Rutger J van Bommel, Roberto Diletti, Jeroen M Wilschut, Peter P de Jaegere, F Zijlstra, Joost Daemen, Nicolas M Van Mieghem
BACKGROUND: Coronary artery perforation (CAP) is a potentially lethal complication of percutaneous coronary intervention. We report on the incidence, clinical characteristics, and management of iatrogenic coronary perforations based on an 11-year single-center experience. METHODS AND RESULTS: From February 9, 2005, through November 20, 2016, 150 CAP cases were identified from our percutaneous coronary intervention database of 21 212 procedures (0.71%). Mean age of CAP patients was 66±11 years, and 62...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28938815/charge-transfer-mobility-and-electrical-conductivity-of-pani-as-conjugated-organic-semiconductors
#18
Yahong Zhang, Yuping Duan, Lulu Song, Daoyuan Zheng, Mingxing Zhang, Guangjiu Zhao
The intramolecular charge transfer properties of a phenyl-end-capped aniline tetramer (ANIH) and a chloro-substituted derivative (ANICl) as organic semiconductors were theoretically studied through the first-principles calculation based on the Marcus-Hush theory. The reorganization energies, intermolecular electronic couplings, angular resolution anisotropic mobilities, and density of states of the two crystals were evaluated. The calculated results demonstrate that both ANIH and ANICl crystals show the higher electron transfer mobilities than the hole-transfer mobilities, which means that the two crystals should prefer to function as n-type organic semiconductors...
September 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28938799/x-ray-reflectivity-studies-on-the-mixed-langmuir-blodgett-monolayers-of-thiol-capped-gold-nanoparticle-dppc-and-sds
#19
Yi-Tang Chen, Han-Shiou Su, Chin-Hua Hung, Po-Wei Yang, Yuan Hu, Tsang-Lang Lin, Ming-Tao Lee, U-Ser Jeng
Langmuir-Blodgett monolayers of the thiolated gold nanoparticles mixed with DPPC/SDS were investigated by combining the X-ray reflectivity, grazing-incident scattering, and TEM analyses to reveal the in-depth and in-plane organization and the 2D morphology of such mixed monolayers. It was found that the addition of charged single tail surfactant to the thiolated Au nanoparticle monolayer helps to stabilize the Au nanoparticle monolayer and to strengthen the mechanical property of the mixed monolayer film. For mixing with lipids, it was found that the thiolated gold nanoparticles could be pushed on top of the lipid monolayer when the mixed monolayer is compressed...
September 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28938580/diagnostic-significance-of-urinary-long-non-coding-pca3-rna-in-prostate-cancer
#20
Tao Wang, Xiangyun Qu, Jiajia Jiang, Peng Gao, Dingding Zhao, Xueqi Lian, Xiaohua Li
Prostate cancer antigen 3(PCA3) is a long non-coding RNA, which was found increased expression in CaP patients than healthy individual. In this study, the individual nucleic acid of PCA3 and PSA was recombinant expressed as a reference reagent, and a quantitative RT-PCR with TaqMan assay was developed to examine the copies of PCA3 and PSA gene in urine. The results showed that the area under the receiver operating characteristic curve (AUROC) was 0.717, 0.444 and 0.916 for the number of PCA3 copy, PSA copy and for the score of PCA3/PSA RNA, respectively...
August 29, 2017: Oncotarget
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