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https://www.readbyqxmd.com/read/29649030/resistin-is-a-novel-marker-for-postoperative-pain-intensity
#1
Jun Hozumi, Masahiko Sumitani, Daisuke Nishizawa, Makoto Nagashima, Kazutaka Ikeda, Hiroaki Abe, Ryoji Kato, Yoshiomi Kusakabe, Yoshitsugu Yamada
BACKGROUND: Pro- and anti-inflammatory cytokines (adipokines) associated with adipose tissue can modulate inflammatory processes and lead to systemic inflammatory conditions such as metabolic syndrome. In the present pilot study, we investigated 3 major adipokines (leptin, adiponectin, and resistin) and 2 nonspecific proinflammatory cytokines (tumor necrosis factor α and interleukin-6) with regard to their association with postoperative pain intensity. METHODS: We analyzed a total of 45 single-nucleotide polymorphisms of the adipokines in 57 patients with postlaparotomy pain...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29627241/influence-of-adipocyte-size-and-adipose-depot-on-the-number-of-adipose-tissue-macrophages-and-the-expression-of-adipokines-in-dairy-cows-at-the-end-of-pregnancy
#2
E Depreester, J De Koster, M Van Poucke, M Hostens, W Van den Broeck, L Peelman, G A Contreras, G Opsomer
The aim of this study was to determine the number of adipose tissue macrophages (ATM) and the mRNA expression of adipokines [adiponectin (ADIPOQ), leptin (LEP), interleukin 6 (IL6), tumor necrosis factor (TNF), and interleukin 10 (IL10)] in different adipose depots from cows with a variable body condition score (BCS) at the end of the dry period. We hypothesized that the number of ATM and the expression of these adipokines depend on adipocyte size and the anatomical location of the adipose depot. Subcutaneous, omental, mesenteric, perirenal, and intrapelvic adipose tissue samples were taken immediately after euthanasia of 10 Holstein Friesian dairy cows (upcoming parity 2 to 5, age 3...
April 4, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29581238/role-of-dysfunctional-adipocytes-in-cholesterol-induced-nonobese-metabolic-syndrome
#3
Jiung-Pang Huang, Sheng-Chieh Hsu, Yaa-Jyuhn James Meir, Po-Shiuan Hsieh, Chih-Chun Chang, Kuan-Hsing Chen, Jan-Kan Chen, Li-Man Hung
Many studies have reported the causes of obese metabolic syndrome (MS); however, the causes of nonobese MS (NMS) remain unknown. In this study, we demonstrated that inflamed dysfunctional adipose tissue plays a crucial role in cholesterol-induced NMS. Control (C), high cholesterol (HC) and HC with 10% fructose in drinking water (HCF) diets were fed to Sprague-Dawley rats for 12 weeks. After 12 weeks, the body weights of the C- and HC-fed rats were comparable, but the weights of the HCF-fed rats were relatively low...
May 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29527418/the-adipokine-c1q-tnf-related-protein-3-ctrp3-is-elevated-in-the-breast-milk-of-obese-mothers
#4
Megan R Kwon, Eileen Cress, W Andrew Clark, Arsham Alamian, Yongke Lu, Jonathan M Peterson
Background: C1q TNF related protein 3 (CTRP3) is a relatively novel hormonal factor primarily derived from adipose tissue and has anti-diabetic properties. To determine if CTRP3 could play a role in early childhood development, the purpose of this study was to establish the presence of CTRP3 in breast milk (BM) and to determine whether CTRP3 levels were correlated with pregravid obesity status of the mother. Methods: Breast milk was collected from breast-feeding mothers who had a pregravid body mass index (BMI) classification of normal weight (BMI 18-25 kg/m2 , n = 23) or obese (BMI > 30 kg/m2 , n = 14)...
2018: PeerJ
https://www.readbyqxmd.com/read/29497960/systemic-inflammation-in-severe-obese-patients-undergoing-surgery-for-obesity-and-weight-related-diseases
#5
Wilson R Freitas, Luis Vicente Franco Oliveira, Eduardo A Perez, Elias J Ilias, Carina P Lottenberg, Anderson S Silva, Jessica J Urbano, Manoel C Oliveira, Rodolfo P Vieira, Marcelo Ribeiro-Alves, Vera L S Alves, Paulo Kassab, Fabio R Thuler, Carlos A Malheiros
BACKGROUND: Obesity is a worldwide disease related to genetic, environmental, and behavioral factors, and it is associated with high rates of morbidity and mortality. Recently, obesity has been characterized by a low-grade inflammatory state known as inflammome indicated by chronic increases in circulating concentrations of inflammatory markers. The purpose of this study was to evaluate the effect of weight loss induced by surgery for obesity and weight-related diseases on pro-inflammatory cytokine (TNF-α) and anti-inflammatory adipokine (adiponectin) levels, and on an adipose-derived hormone (leptin) in severely obese subjects...
March 1, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29484120/epigallocatechin-3-gallate-suppresses-differentiation-of-adipocytes-via-regulating-the-phosphorylation-of-foxo1-mediated-by-pi3k-akt-signaling-in-3t3-l1-cells
#6
Yi Lu, Junye Chen, Tao Xian, Yumeng Zhou, Wanwan Yuan, Mengxi Wang, Yuyang Gan, Kun Wang, Shaofeng Xiong, Cong Ma, Xueying Yu, Qiren Huang
Epigallocatechin-3-gallate (EGCG) is a pivotal effective component of green tea. It is known that EGCG has antioxidant activity, anti-angiogenesis, anti-tumor, cardiovascular protection and blood lipid regulation functions. Forkhead box-O1 (FOXO1) is one of the downstream signals of protein kinase B (AKT) and takes part in adipogenesis. The purpose of this study is to investigate the effects of EGCG on adipose differentiation and the likely mechanisms. 3T3-L1 cells were induced by DMI for 2, 4, 6 and 8 days, respectively...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29454302/aerobic-exercise-inhibits-obesity-induced-respiratory-phenotype
#7
Jefferson Comin Jonco Aquino-Junior, BreAnne MacKenzie, Ana Roberta Almeida-Oliveira, Ana Carolina Martins, Manoel Carneiro Oliveira-Junior, Auriléa Aparecida Britto, Fernanda Magalhaes Arantes-Costa, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Ana Paula Ligeiro de Oliveira, Dioze Guadagnini, Luiz Osorio Leiria, Djalma Rabelo Ricardo, Mario Jose Abdalla Saad, Rodolfo Paula Vieira
PURPOSE: Obesity results in decreased lung function and increased inflammation. Moderate aerobic exercise (AE) reduced lung inflammation and remodeling in a variety of respiratory disease models. Therefore, this study investigated whether AE can attenuate a diet-induced obesity respiratory phenotype; including airway hyper-responsiveness (AHR), remodeling and inflammation. METHODS: Sixty C57Bl/6 male mice were distributed into four groups: control lean (CL), exercise lean (EL), obese (O) and obese exercise (OE) groups (2 sets of 7 and 8 mice per group; n = 15)...
April 2018: Cytokine
https://www.readbyqxmd.com/read/29384066/relationship-between-proinflammatory-cytokines-chemokines-and-adipokines-in-serum-of-young-adults-with-obesity
#8
Maraisa D Borges, Eduardo L Franca, Mahmi Fujimori, Silvia M C Silva, Patricia G F de Marchi, Alessandra L Deluque, Adenilda C Honorio-Franca, Luiz C de Abreu
BACKGROUND AND OBJECTIVE: The adipose tissue has been recognized as an important endocrine organ, which is metabolically active and expresses and secretes various inflammatory cytokines. Inflammation is involved in obesity-related complications. As such, the present study investigated the correlation between biochemical parameters, serum proinflammatory cytokines and adipokines in individuals with obesity. METHODS: Based on the body mass index (BMI), 30 subjects were divided into 3 groups: eutrophic (GC, n = 10), overweight (GOW, n = 10) and obese (GOB, n = 10)...
2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29299989/curcuminoids-plus-piperine-modulate-adipokines-in-type-2-diabetes-mellitus
#9
Amirhossein Sahebkar, Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Stephen L Atkin, Muhammed Majeed
OBJECTIVE: Curcumin is a naturally occurring polyphenol derived from tumeric that has been reported to have anti-inflammatory properties with effects on adipokine and ghrelin levels. Adiponectin, leptin and ghrelin modulate energy homeostasis but each have modulatory effects on inflammatory cytokines and the immune system. Therefore this analysis was performed to investigate the effect of curcumin on adiponectin, leptin and ghrelin. METHODS: A double blind randomised control trial comparing curcumin 1000mg with 10mg of piperine daily to placebo over a 12 week period...
January 3, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29287006/hyperadiponectinemia-during-infliximab-induction-therapy-in-pediatric-crohn-s-disease
#10
Klara Frivolt, Tobias Schwerd, Stephanie B Schatz, Folke Freudenberg, Christine Prell, Katharina J Werkstetter, Philip Bufler, Sibylle Koletzko
OBJECTIVES: The inflammatory process in Crohn's disease (CD) involves the visceral fat, characterized by adipocyte hyperplasia and altered adipose tissue and serum concentrations of TNF, leptin, adiponectin and resistin. We investigated the effect of anti-TNF therapy with infliximab (IFX) on serum adipokine levels in pediatric CD. METHODS: Serum concentrations of resistin (ng/ml), leptin (ng/ml), and total adiponectin (μg/ml) were assessed by ELISA in 18 pediatric CD patients (mean age 15...
December 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29285143/combination-treatment-with-quercetin-and-resveratrol-attenuates-high-fat-diet-induced-obesity-and-associated-inflammation-in-rats-via-the-ampk%C3%AE-1-sirt1-signaling-pathway
#11
Le Zhao, Fang Cen, Feng Tian, Min-Jie Li, Qi Zhang, Hong-Yi Shen, Xiang-Chun Shen, Ming-Mei Zhou, Jun Du
Diet-induced obesity is associated with systemic inflammation, which is considered to originate predominantly from the adipose tissue. Quercetin and resveratrol are two dietary polyphenols that exhibit anti-inflammatory properties and anti-insulin resistance when administered in isolation or combination (CQR). It remains unknown whether CQR reduces high fat diet (HFD)-induced obesity and inflammation in rats. In the current study, 46 male Wistar rats were divided into two groups, one of which was fed a normal diet (ND, 5...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29235656/nonalcoholic-fatty-liver-disease-in-patients-with-psoriasis-a-consequence-of-systemic-inflammatory-burden
#12
REVIEW
R B Prussick, L Miele
Patients with psoriasis are at an increased risk for nonalcoholic fatty liver disease (NAFLD) compared to the general population. However, the pathophysiology underlying this comorbidity and elucidation of effective treatment strategies are unclear. This review provides insights into the possible role of chronic, low-grade inflammation in the pathogenesis of NAFLD in patients with psoriasis. Both conditions are associated with increased levels of pro-inflammatory adipokines (such as tumor necrosis factor-α and interleukin-6), and hepatokines, and decreased levels of adiponectin, an anti-inflammatory adipokine...
December 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29229313/emerging-role-of-adipocytokines-in-type-2-diabetes-as-mediators-of-insulin-resistance-and-cardiovascular-disease
#13
REVIEW
Ravindran Jaganathan, Rajeswari Ravindran, Sugapriya Dhanasekaran
Adipose tissue is an enormously active endocrine organ, secreting various hormones, such as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). All these adipocytokines plays significant roles in the regulation of energy metabolism, glucose and lipid metabolism, reproduction, cardiovascular function and immunity. Adipocytokines are significantly regulated by nutritional status and can directly influence other organ systems, including brain, liver and skeletal muscle...
December 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29222347/pioglitazone-inhibits-periprostatic-white-adipose-tissue-inflammation-in-obese-mice
#14
Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi Kathy Zhou, Hanhan Wang, Domenick J Falcone, Dilip D Giri, Andrew J Dannenberg
Obesity is associated with an increased incidence of high-grade prostate cancer and poor prognosis for prostate cancer patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was associated with high-grade prostate cancer. It is possible, therefore, that agents that suppress periprostatic WAT inflammation will alter the development or progression of prostate cancer...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29210643/adipokines-and-myokines-a-pivotal-role-in-metabolic-and-cardiovascular-disorders
#15
Hye Soo Chung, Kyung Mook Choi
Obesity induces an imbalance in the expression and secretion of several cytokines, which contributes to the development of metabolic and cardiovascular disorders. On the contrary, skeletal muscle is known to have a role in reversing the detrimental impact of obesity. It has been established that adipose tissue acts as an endocrine organ that secretes proinflammatory and anti-inflammatory adipokines. Similarly, skeletal muscle produces secretory molecules, called myokines, from contracting muscle fibers. Myokines were recently recognized as beneficial modulators of obesity, metabolic syndrome, and type 2 diabetes...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29137283/c1q-tumor-necrosis-factor-related-protein-3-protects-macrophages-against-lps-induced-lipid-accumulation-inflammation-and-phenotype-transition-via-ppar%C3%AE-and-tlr4-mediated-pathways
#16
Jiale Lin, Qi Liu, Hui Zhang, Xingtao Huang, Ruoxi Zhang, Shuyuan Chen, Xuedong Wang, Bo Yu, Jingbo Hou
Macrophage inflammation and foam cell formation are critical events during the initiation and development of atherosclerosis (AS). C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with anti-inflammatory and cardioprotection properties; however, little is known regarding the influence of CTRP3 on AS. As macrophages play a key role in AS, this study investigated the effects of CTRP3 on macrophage lipid metabolism, inflammatory reactions, and phenotype transition, as well as underlying mechanisms, to reveal the relationship between CTRP3 and AS...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048484/adiponectin-suppression-of-late-inflammatory-mediator-hmgb1-induced-cytokine-expression-in-raw264-macrophage-cells
#17
Mohamed Elfeky, Takeshi Yoneshiro, Yuko Okamatsu-Ogura, Kazuhiro Kimura
High-mobility group protein B1 (HMGB1) is a late inflammatory mediator released from inflammatory cells when stimulated, resulting in exaggerating septic symptoms. We recently demonstrated that full-length adiponectin, a potent anti-inflammatory adipokine, inhibits lipopolysaccharide-induced HMGB1 release. However, the effects of adiponectin on HMGB1-induced exaggerating signals currently remain unknown. This study aimed to investigate the effects of adiponectin on the pro-inflammatory function of HMGB1 in RAW264 macrophage cells...
February 1, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/28948552/adipokine-and-cytokine-profiles-of-epicardial-and-subcutaneous-adipose-tissue-in-patients-with-coronary-heart-disease
#18
O V Gruzdeva, O E Akbasheva, Yu A Dyleva, L V Antonova, V G Matveeva, E G Uchasova, E V Fanaskova, V N Karetnikova, S V Ivanov, O L Barbarash
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28929125/the-association-of-inflammatory-markers-with-nonalcoholic-fatty-liver-disease-differs-by-human-immunodeficiency-virus-serostatus
#19
Jennifer C Price, Ruibin Wang, Eric C Seaberg, Matthew J Budoff, Lawrence A Kingsley, Frank J Palella, Mallory D Witt, Wendy S Post, Chloe L Thio
BACKGROUND: We aimed to determine the relationship of circulating adipokines and inflammatory biomarkers with fatty liver among men in the Multicenter AIDS Cohort Study. METHODS: Noncontrast computed tomography was used to assess fatty liver and measure abdominal visceral adipose tissue (VAT) area in 526 participants without history of cardiovascular disease, heavy alcohol use, or viral hepatitis infection. Multivariable logistic regression was used to assess associations of circulating biomarker levels with fatty liver...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28809783/role-of-omentin-vaspin-cardiotrophin-1-tweak-and-nov-ccn3-in-obesity-and-diabetes-development
#20
REVIEW
Xavier Escoté, Saioa Gómez-Zorita, Miguel López-Yoldi, Iñaki Milton-Laskibar, Alfredo Fernández-Quintela, J Alfredo Martínez, María J Moreno-Aliaga, María P Portillo
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed...
August 15, 2017: International Journal of Molecular Sciences
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