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Ji Hyun Lee, Han Na Park, Ji Yeon Choi, Nam Sook Kim, Hyung-Joon Park, Seong Soo Park, Sun Young Baek
Adulterated products are continuously detected in society and cause problems. In this study, we developed and validated a method for determining synthetic sedative-hypnotics and sleep inducers, including barbital, benzodiazepam, zolpidem, and first-generation antihistamines, in adulterated products using Quadrupole-Orbitrap mass spectrometry and ultrahigh performance liquid chromatography with tandem mass spectrometry. In Quadrupole-Orbitrap mass spectrometry analysis, target compounds were confirmed using a combination of retention time, mass tolerance, mass accuracy, and fragment ions...
December 2017: Journal of Separation Science
Cho-Kai Wu, Yin-Tseng Huang, Jen-Kuang Lee, Jyh-Ming Jimmy Juang, Chia-Ti Tsai, Ling-Pin Lai, Juey-Jen Hwang, Fu-Tien Chiang, Jiunn-Lee Lin, Pau-Chung Chen, Lian-Yu Lin
OBJECTIVE: Anti-anxiety medication in patients with anxiety may lessen the stress and thereby lower their risk for myocardial infarction (MI). The aim of current study is to examine an association between the use of anti-anxiety medication and long-term mortality risk in patients following MI. METHODS: A universal national health insurance (NHI) program has been implemented in Taiwan since 1995. We used system sampling database from 1997 to 2008 with a total of 1,000,000 subjects...
August 2014: Atherosclerosis
Karthik Rajasekaran, Marko Todorovic, Jaideep Kapur
OBJECTIVE: A study was undertaken to characterize the plasticity of AMPA receptor (AMPAR)-mediated neurotransmission in the hippocampus during status epilepticus (SE). METHODS: SE was induced by pilocarpine, and animals were studied 10 minutes (refractory SE) or 60 minutes (late SE) after the onset of the first grade 5 seizures. AMPAR-mediated currents were recorded from CA1 pyramidal neurons and dentate granule cells (DGCs) by voltage clamp technique. The surface expression of GluA2 subunit on hippocampal membranes was determined using a biotinylation assay...
July 2012: Annals of Neurology
Che-Lin Yueh, Sung-Lin Yu, Hsiao-Min Chen, Bo-Jian Wu, Wen-Ching Chen
Aripiprazole has been recognised as a third generation antipsychotic and is considered to be distinguished from typical and atypical antipsychotics. In clinical trials, researchers did not mention the risk of aripiprazole-induced seizure, but during a literature review a case report was found that discussed this potential side effect. The present report concerns a 54-year-old man with chronic schizophrenia who developed a witnessed grand mal seizure after he had abruptly discontinued clozapine and benzodiazepam (BZD) treatment and concurrently reinitiated aripiprazole treatment as the result of an involuntary clinical error...
2009: BMJ Case Reports
M G García, A García, I Gonzaléz
A method for the extraction and separation of the active ingredient diazepam (7-chloro-di-hydro-1-methyl-5-phenyl-2H, -1,4-benzodiazepam-2-one) in pharmaceutical tablets is discussed. This method avoids the hydrolysis of diazepam. Polarographic studies with direct current (DCP), alternating current (ACP) and differential pulse polarography (DPP) were used under different sets of conditions. The pH value most suitable for these studies was found to be 4.6. The detection range for ACP was found to be from 17...
December 1993: Talanta
Nancy Kim, Elva Delport, Tony Cucuzzella, Julie Marley, Christine Pruitt
STUDY DESIGN: Survey. OBJECTIVE: The purpose of this research was to help determine whether sedation is indicated before lumbar and cervical interventional pain management procedures, and additionally, to determine whether benzodiazepams are effective at controlling anxiety for these procedures. SUMMARY OF BACKGROUND DATA: The use of sedation before diagnostic and therapeutic epidurals seems to vary widely and no guidelines have been issued that address whether sedation is indicated and for which patients...
December 1, 2007: Spine
Bernd Gutmann, Claudio Crivellaro, Manfred Mitterer, Hermann Zingerle, Eduard Egarter-Vigl, Christian J Wiedermann
Paraneoplastic neurologic syndromes associated with Hodgkin's lymphoma include the stiff-person syndrome. A case of stiff-person syndrome is reported who first presented with muscular hyperactivity and acute respiratory failure followed by heterotopic soft tissue ossification and acute seronegative gonarthitis. Initial improvement of a tetanus-like clinical picture was achieved with benzodiazepam given by continuous infusion for analgo-sedation to mechanically ventilate the patient followed by baclofen after successful weaning...
December 2006: Haematologica
C Chiron, N Bahi-Buisson, P Plouin
The treatment of status epilepticus (SE) in children with epilepsy depends on the epilepsy syndrome, in order to avoid worsening drugs such as IV barbiturates in severe myoclonic epilepsy in infancy (SMEI) (Dravet's syndrome) or IV benzodiazepam in tonic SE of Lennox-Gastaut syndrome. Intensive care procedures should not be systematical in convulsive SE (CSE) and are not indicated in non-convulsive SE (NCSE). Generalized CSE mostly involve SMEI before 3 years of age, symptomatic generalized epilepsy and partial lesional epilepsy...
October 2004: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
No abstract text is available yet for this article.
February 1964: Toko-ginecología Práctica
No abstract text is available yet for this article.
November 7, 1963: La Semana Médica
C A McCarty, C A Wood, C L Fu, P M Livingston, S Mackersey, Y Stanislavsky, H R Taylor
OBJECTIVE: To compare the distribution of cataract types between psychiatric patients diagnosed with schizophrenia and the general population not exposed to psychotropic medication, and to compare cataract prevalence between users and nonusers of various psychotropic medications in the general community. DESIGN: Case-control. PARTICIPANTS: A total of 151 (93%) eligible patients from a community mental health service and 3271 (83%) eligible residents from the Melbourne Visual Impairment Project (VIP) were examined...
April 1999: Ophthalmology
T L Huang, S C Ree, Y C Huang, H Y Liu, Y Y Yang
During a 2-year period, 34 patients of catatonic features in Chinese ethnic background Taiwanese were brought to the emergency unit of Chang Gung Memorial Hospital at Linkou. The ratios of the causes of catatonic features by schizophrenic disorders, mood disorders, neuroleptic-induced disorders, and general medical conditions were 26, 9, 24 and 41%, respectively. After the treatments of antipsychotics, benzodiazepam, or electroconvulsive therapy (ECT), 24 patients (70.6%) showed complete remission, seven patients (20...
February 1999: Psychiatry and Clinical Neurosciences
A P Wines, M H Khadra, R D Wines
BACKGROUND: Modern surgical practice is stressful and anxiety-producing. We investigated urologists health and their attitude to their own health care. METHODS: Two hundred and seventy-five Australasian urologists were surveyed to ascertain their attitudes to their physical and psychological health; 205 responses were received. RESULTS: Ten per cent reported serious physical illnesses. Fewer than half had their own general practitioner (GP), and fewer than one-third had seen a doctor in the previous 12 months...
November 1998: Australian and New Zealand Journal of Surgery
B T Woodson, T Feroah, L A Connolly, R J Toohill
PURPOSE: To describe a method that measures multisegment upper airway changes following intervention for snoring and obstructive apnea that controls for physiological fluctuations during sleep. PATIENTS AND METHODS: Retropalatal, retroglossal, and retrohyoid airway segments were evaluated before and after application of an oral appliance (OA) in four snoring subjects. Twelve airway segments were evaluated. Physiological fluctuations during sleep were controlled with variably applied nasal continuous positive pressure (CPAP), benzodiazepam-induced sleep, and obtaining measures at zero flow on the first test breath...
September 1997: American Journal of Otolaryngology
C L Feng, Y T Liu, Y Luo
An HPLC-DAD qualitative and quantitative method for the analysis of thirteen soporific sedative drugs in human blood established. These drugs were separated by HPLC with acetonitrile-water (35 : 65) (for barbital drugs), methanol-water (60 : 40) and methanol-10% triethylamine acetic acid solution (pH 7.5) (for benzodiazepam and phenothiazine drugs) as eluting phase systems and were detected with photodiode array detector (DAD). These drugs were identified by their spectral characteristics and retention times and quantitatively determined by their peak areas...
December 1995: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
R Alemzadeh, K Gammeltoft, K Matteson
Nonketotic hyperglycinemia (NKH) is an inborn error of glycine degradation causing muscular hypotonia, seizures, apnea, and lethargy; it has a poor prognosis. Accumulation of glycine in the brain is thought to cause excessive stimulation of the N-methyl-D-aspartate receptor. Dextromethorphan (DM), an N-methyl-D-aspartate receptor antagonist, in doses of 5 to 35 mg/kg per day has been shown to have beneficial therapeutic effects in some patients with NKH. We report the case of a 1-year-old infant with NKH, seizure disorder, and psychomotor delay who was clinically seizure free during treatment with sodium benzoate, arginine, benzodiazepam, and phenobarbital...
June 1996: Pediatrics
S M Boyd, M Beverley, L Norskov, R E Hubbard
We have developed a program, HookSpace, which provides a simplistic approach to assessing the diversity of molecular databases. The spatial relationship between pairs of intramolecular functional groups can be analysed in a variety of ways to provide both qualitative and quantitative measures of diversity. Results are described and contrasted for two commercially available databases and a combinatorial library of benzodiazepam derivatives. HookSpace highlights the main differences in molecular content of these data sets...
October 1995: Journal of Computer-aided Molecular Design
H Saji, Y Iida, I Nakatsuka, M Kataoka, K Ariyoshi, Y Magata, A Yoshitake, A Yokoyama
2'-Iododiazepam (2'-IDZ) is the diazepam analogue iodinated at the 2'-position of C-5 phenyl ring which was synthesized and evaluated as a potential radiopharmaceutical for investigating brain benzodiazepine receptors by SPECT. The 125I-2'-iododiazepam was synthesized by halogen exchange reaction and purified by HPLC. In vitro competitive binding studies with 3H-diazepam, using rat cortical synaptosomal membranes, showed that the affinity of 2'-IDZ for benzodiazepam receptors was higher than that in diazepam and flumazenil (RO15-1788)...
June 1993: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
H A Robertson
Brain benzodiazepine receptor binding was determined in two inbred strains of mice, one of which is susceptible to audiogenic seizures. Specific binding of 3H-flunitrazepam was higher in the seizure-susceptible DBA/2J strain (at about 22 days of age) when compared to age-matched, seizure-resistant C57BL/6J mice. Like seizure susceptibility, the differences in benzodiazepine binding were age-related. The DBA/2J strain had higher benzodiazepine binding whether convulsed or not. In well-washed brain membrane fragments specific 3H-flunitrazepam binding was also higher in the DBA/2J strain suggesting that the difference was not due to the presence of an endogenous ligand...
August 29, 1980: European Journal of Pharmacology
F Rodriguez Suárez, A Concepción Pérez
No abstract text is available yet for this article.
March 1967: Revista Española de Oto-neuro-oftalmología y Neurocirugía
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