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https://www.readbyqxmd.com/read/29024485/placenta-derived-adherent-stromal-cells-improve-diabetes-mellitus-associated-left-ventricular-diastolic-performance
#1
Sophie Van Linthout, Nazha Hamdani, Kapka Miteva, Annika Koschel, Irene Müller, Lena Pinzur, Zami Aberman, Kathleen Pappritz, Wolfgang Albrecht Linke, Carsten Tschöpe
Left ventricular (LV) diastolic dysfunction is among others attributed to cardiomyocyte stiffness. Mesenchymal stromal cells (MSC) have cardiac-protective properties. We explored whether intravenous (i.v.) application of PLacenta-eXpanded (PLX) MSC-like cells (PLX) improves LV diastolic relaxation in streptozotocin (STZ)-induced diabetic mice and investigated underlying mechanisms. Diabetes mellitus was induced by STZ application (50 mg/kg body weight) during five subsequent days. One week after the first STZ injection, PLX or saline were i...
October 10, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28982045/pregnancy-outcomes-of-women-randomized-to-receive-real-versus-placebo-acupuncture-on-the-day-of-fresh-or-frozen-thawed-embryo-transfer
#2
Mimi T Y Seto, Ka Wang Cheung, Tsz Kin Lo, Ernest H Y Ng
INTRODUCTION: Acupuncture is commonly used in various aspect of Western medicine in recent years including in-vitro fertilization (IVF) treatment. Although there are many clinical trials of acupuncture in IVF and the Cochrane meta-analysis did not find benefit of adjuvant acupuncture for IVF, there is no report on the pregnancy outcomes of women who had received acupuncture during their IVF treatment. OBJECTIVES: To compare the pregnancy outcomes of women randomized to receive real versus placebo acupuncture during their IVF treatment...
September 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28967638/postnatal-extra-embryonic-tissues-as-a-source-of-multiple-cell-types-for-regenerative-medicine-applications
#3
O S Gubar, A E Rodnichenko, R G Vasyliev, A V Zlatska, D O Zubov
AIM: We aimed to isolate and characterize the cell types which could be obtained from postnatal extra-embryonic tissues. MATERIALS AND METHODS: Fresh tissues (no more than 12 h after delivery) were used for enzymatic or explants methods of cell isolation. Obtained cultures were further maintained at 5% oxygen. At P3 cell phenotype was assessed by fluorescence-activated cell sorting, population doubling time was calculated and the multilineage differentiation assay was performed...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28955183/a-brief-account-of-the-discovery-of-the-fetal-placental-unit-for-estrogen-production-in-equine-and-human-pregnancies-relation-to-human-medicine
#4
REVIEW
James I Raeside
The role of steroids in human medicine is well recognized, but the major contributions made by the large domestic animals as a source of material in the discovery, isolation, and determination of the structure of the steroid hormones is less well appreciated. After a brief reminder of the early efforts to obtain a reliable source of steroids for clinical use, the narrative here is to outline one example where success was ultimately achieved for estrogen replacement therapy. Whereas knowledge of the high concentrations of estrogens in urine of pregnant women and mares dates from the late 1920s, it was not until the 1940s that the latter was shown to be a practical source...
September 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28874054/critical-view-on-mesenchymal-stromal-cells-in-regenerative-medicine
#5
Agnieszka Langrzyk, Witold N Nowak, Jacek Stępniewski, Agnieszka Jaźwa, Urszula Florczyk-Soluch, Alicja Józkowicz, Józef Dulak
SIGNIFICANCE: The belief in the potency of stem cells has resulted in the medical applications of numerous cell types for organ repair, often with the low adherence to methodological stringency. Such uncritical enthusiasm is mainly presented in the approaches employing so-called mesenchymal stem cells (MSC), for the treatment of numerous, unrelated conditions. However, it should be stressed that such broad clinical applications of MSC are mostly based on the belief that MSC can efficiently differentiate into multiple cell types, not only osteoblasts, chondrocytes and adipose cells...
October 11, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28871576/first-trimester-combined-screening-for-preeclampsia-and-small-for-gestational-age-a-single-centre-experience-and-validation-of-the-fmf-screening-algorithm
#6
Beatrice Mosimann, Chantal Pfiffner, Sofia Amylidi-Mohr, Lorenz Risch, Daniel Surbek, Luigi Raio
AIM OF THE STUDY: Preeclampsia (PE) is associated with severe maternal and fetal morbidity in the acute presentation and there is increasing evidence that it is also an important risk factor for cardiovascular disease later in life. Therefore, preventive strategies are of utmost importance. The Fetal Medicine Foundation (FMF) London recently developed a first trimester screening algorithm for placenta-related pregnancy complications, in particular early onset preeclampsia (eoPE) requiring delivery before 34 weeks, and preterm small for gestational age (pSGA), with a birth weight <5th percentile and delivery before 37 weeks of gestation, based on maternal history and characteristics, and biochemical and biophysical parameters...
September 5, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28782117/risk-factors-for-blood-transfusion-in-patients-undergoing-high-order-cesarean-delivery
#7
Jessica Spiegelman, Mirella Mourad, Stephanie Melka, Simi Gupta, Jennifer Lam-Rachlin, Andrei Rebarber, Daniel H Saltzman, Nathan S Fox
BACKGROUND: The objective was to identify risk factors associated with blood transfusion in patients undergoing high-order Cesarean delivery (CD). STUDY DESIGN AND METHODS: This was a retrospective cohort study of patients undergoing third or more CD by a single maternal-fetal medicine practice between 2005 and 2016. We compared risk factors between women who did and did not receive a red blood cell transfusion during the operation or before discharge. Repeat analysis was performed after excluding women with placenta previa...
August 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28744284/safety-and-side-effects-of-using-placenta-derived-decidual-stromal-cells-for-graft-versus-host-disease-and-hemorrhagic-cystitis
#8
Arjang Baygan, Wictor Aronsson-Kurttila, Gianluca Moretti, Babylonia Tibert, Göran Dahllöf, Lena Klingspor, Britt Gustafsson, Bita Khoein, Guido Moll, Charlotta Hausmann, Britt-Marie Svahn, Magnus Westgren, Mats Remberger, Behnam Sadeghi, Olle Ringden
Mesenchymal stromal cells (MSCs) are increasingly used in regenerate medicine. Placenta-derived decidual stromal cells (DSCs) are a novel therapy for acute graft-versus-host-disease (GVHD) and hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT). DSCs are more immunosuppressive than MSCs. We assessed adverse events and safety using DSCs among 44 treated patients and 40 controls. The median dose of infused cells was 1.5 (range 0.9-2.9) × 10(6) DSCs/kg. The patients were given 2 (1-5) doses, with a total of 82 infusions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28729106/no-223-content-of-a-complete-routine-second-trimester-obstetrical-ultrasound-examination-and-report
#9
Yvonne Cargill, Lucie Morin
OBJECTIVE: To review the benefits of and requirements for a complete second trimester ultrasound and the documentation needed. OUTCOMES: A complete second trimester ultrasound provides information about the number of fetuses, the gestational age, the location of the placenta, and fetal and maternal anatomy. EVIDENCE: In the production of this document, the American Institute of Ultrasound in Medicine's "Practice Guideline for the Performance of Obstetric Ultrasound Examinations," the American College of Obstetricians and Gynecologists' practice bulletin, "Ultrasound in Pregnancy," and the Royal College of Obstetricians and Gynaecologists' Working Party Report, "Ultrasound Screening" were reviewed...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28729105/n-o-223-tenue-syst%C3%A3-matique-d%C3%A2-un-examen-%C3%A3-chographique-obst%C3%A3-trical-au-cours-du-deuxi%C3%A3-me-trimestre-contenu-d%C3%A2-un-examen-et-d%C3%A2-un-rapport-exhaustifs
#10
Yvonne Cargill, Lucie Morin
OBJECTIF: Analyser les avantages d'un examen échographique exhaustif au cours du deuxième trimestre et les conditions nécessaires à sa tenue, ainsi que la documentation requise. ISSUES: Un examen échographique exhaustif au cours du deuxième trimestre offre des renseignements au sujet du nombre de fœtus, de l'âge gestationnel, de l'emplacement du placenta et de l'anatomie fœtale et maternelle. RéSULTATS: Dans le cadre de la rédaction du présent document, le document « Practice Guideline for the Performance of Obstetric Ultrasound Examinations » du American Institute of Ultrasound in Medicine, le bulletin de pratique « Ultrasound in Pregnancy » du American College of Obstetricians and Gynaecologists et le rapport de groupe de travail « Ultrasound Screening » du Royal College of Obstetricians and Gynaecologists ont été analysés...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28723688/trigonelline-inhibits-inflammation-and-protects-%C3%AE-cells-to-prevent-fetal-growth-restriction-during-pregnancy-in-a-mouse-model-of-diabetes
#11
Ji-Yin Zhou, Xiao-Huang Du, Zuo Zhang, Gui-Sheng Qian
BACKGROUND: As an active component from traditional Chinese medicine, trigonelline has a protective effect on diabetes. This study evaluated the protective effects of trigonelline on diabetic mice during pregnancy. METHODS: Diabetes was induced in female mice by intraperitoneal injection for continuous 5-day of 40 mg/kg/day streptozotocin. Female mice were divided into 4 groups after they were allowed to mate with normal male mice: nondiabetic, nondiabetic treated with trigonelline (70 mg/kg) for 18 days, diabetic, and diabetic treated with trigonelline (70 mg/kg)...
July 20, 2017: Pharmacology
https://www.readbyqxmd.com/read/28680464/-to-test-or-not-to-test-the-arguments-for-and-against-thrombophilia-testing-in-obstetrics
#12
REVIEW
Laura Ormesher, Louise E Simcox, Clare Tower, Ian A Greer
Clinicians increasingly investigate women for thrombophilias due to their associations with venous thromboembolism and placenta-mediated pregnancy complication. These associations, however, are modest and based largely on retrospective data from studies with heterogeneous classifications and populations, leading to discordance between evidence and guidelines. Current evidence suggests a contributory rather than causative role for thrombophilia in placenta-mediated pregnancy complication and venous thromboembolism...
June 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/28677080/comparison-of-impact-of-two-decontamination-solutions-on-the-viability-of-the-cells-in-human-amnion
#13
Ingrida Smeringaiova, Peter Trosan, Miluse Berka Mrstinova, Jan Matecha, Jan Burkert, Jan Bednar, Katerina Jirsova
Human amniotic membrane (HAM) is used as an allograft in regenerative medicine or as a source of pluripotent cells for stem cell research. Various decontamination protocols and solutions are used to sterilize HAM before its application, but little is known about the toxicity of disinfectants on HAM cells. In this study, we tested two decontamination solutions, commercial (BASE·128) and laboratory decontamination solution (LDS), with an analogous content of antimycotic/antibiotics for their cytotoxic effect on HAM epithelial (EC) and mesenchymal stromal cells (MSC)...
July 4, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28651900/potential-clinical-applications-of-placental-stem-cells-for-use-in-fetal-therapy-of-birth-defects
#14
Melissa Vanover, Aijun Wang, Diana Farmer
Placental stem cells are of growing interest for a variety of clinical applications due to their multipotency and ready availability from otherwise frequently discarded biomaterial. Stem cells derived from the placenta have been investigated in a number of disease processes, including wound healing, ischemic heart disease, autoimmune disorders, and chronic lung or liver injury. Fetal intervention for structural congenital defects, such as spina bifida, has rapidly progressed as a field due to advances in maternal-fetal medicine and improving surgical techniques...
May 18, 2017: Placenta
https://www.readbyqxmd.com/read/28647962/-effect-of-endoplasmic-reticulum-stress-in-trophocytes-on-the-pathogenesis-of-intrahepatic-cholestasis-of-pregnancy
#15
Y Yu, C L Zhou, T T Yu, X J Han, H Y Shi, H Z Wang, J J Shen, J He
Objective: To evaluate the effect of endoplasmic reticulum stress in trophocytes, in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: Sixty-one pregnant women who were hospitalized in Women's Hospital, School of Medicine, Zhejiang University from January to December 2015 were recruited. Thirty-one women who were diagnosed as ICP were defined as the ICP group and 30 healthy pregnant women were defined as the control group. The localization and expression intensity of glucose regulated protein 78 (GRP-78) in placental tissues were detected by immunohistochemistry technique...
June 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28640786/a-standardized-approach-for-transfusion-medicine-support-in-patients-with-morbidly-adherent-placenta
#16
Anil K Panigrahi, Amanda Yeaton-Massey, Sara Bakhtary, Jennifer Andrews, Deirdre J Lyell, Alexander J Butwick, Lawrence Tim Goodnough
BACKGROUND: The incidence of placenta accreta (PA) has increased from 0.8 to 3.0 in 1000 pregnancies, driven by increased rates of cesarean deliveries (32.2% in 2014) of births in the United States. The average blood loss for a delivery complicated by PA ranges from 2000 to 5000 mL, frequently requiring substantial transfusion medicine support. We report our own institutional multidisciplinary approach for managing such patients, along with transfusion medicine outcomes, in this setting over a 5-year period...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28593775/-the-importance-of-maternal-microbiome-in-pregnancy
#17
J Záhumenský, J Hederlingová, P Pšenková
OBJECTIVE: To bring the most actual published findings of the influence of maternal microbiome on the development of pregnancy and possibilities of its adjusting. DESIGN: Review. SETTING: 2nd Department of Gyneacology and Obstetrics of the Faculty of Medicine and the University Hospital, Bratislava. METHODS: Review of the literature. CONCLUSIONS: The appearance of microbes on various body surface areas determines the overall health status of the individual in significant manner...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28585843/triple-pregnancy-with-mixed-chorionicity-following-in-vitro-fertilization-is-fetal-reduction-neccesary
#18
A Sobek, M Procházka, E Klásková, B Zbořilová, M Lubušký, A Sobek
OBJECTIVE: The increasing incidence and management of monozygotic twinning in patients undergoing in vitro fertilization (IVF) has been the subject of much debate. Here, we describe the management and outcome of two triple pregnancies with mixed chorionicity with a monochorionic-diamniotic twin pair and a singleton following the transfer of two embryos during IVF treatment. DESIGN: Case report. SETTING: Department of Obstetrics and Gynaecology, Palacký University Hospital, Olomouc, Czech Republic...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28584334/-nanogold-biological-effects-and-occupational-exposure-levels
#19
REVIEW
Anna Maria Świdwińska-Gajewska, Sławomir Czerczak
Nanogold has different properties and biological activity compared to metallic gold. It can be applied in many fields, such as medicine, laboratory diagnostics and electronics. Studies on laboratory animals show that nanogold can be absorbed by inhalation and ingestion. It can penetrate deep into the epidermis and dermis, but there is no evidence that it is absorbed through the skin. Gold nanoobjects accumulate mainly in the liver and spleen, but they can also reach other internal organs. Nanogold can cross the blood-brain and blood-placenta barriers...
June 27, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28560047/effects-of-dexamethasone-on-progesterone-and-estrogen-profiles-and-uterine-progesterone-receptor-localization-during-pregnancy-in-sahel-goat-in-semi-arid-region
#20
Dauda Yahi, Nicholas Adetayo Ojo, Gideon Dauda Mshelia
BACKGROUND: Despite the widespread use of dexamethasone in veterinary and human medicine, it is reported to cause some severe pregnancy related side effects like abortion in some animals. The mechanism of the response is not clear but seems to be related to interspecies and/or breed difference in response which may involve alterations in the concentrations of some reproductive hormones. METHODS: Twenty Sahel goats comprising 18 does and 2 bucks were used for this study...
2017: Journal of Animal Science and Technology
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