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https://www.readbyqxmd.com/read/28743173/improvement-and-persistent-disparities-in-completion-lymph-node-dissection-lessons-from-the-national-cancer-database
#1
Brian S Chu, Wima Koffi, Richard S Hoehn, Audrey Ertel, Shimul A Shah, Syed A Ahmad, Jeffrey J Sussman, Heather B Neuman, Daniel E Abbott
BACKGROUND: Completion lymph node dissection (CLND) is recommended for melanoma patients with positive sentinel lymph node biopsies (SLNB); however, 50% do not undergo CLND. We sought to determine CLND trends over time, and factors contributing to variability. METHODS: The NCDB was queried for patients undergoing wide local excision (WLE), with or without SLNB and CLND. Cohorts were created based on demographic/socioeconomic variables and era of treatment (Era 1: 2003-07, Era 2: 2008-12)...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28743172/modelling-nutritional-mutualisms-challenges-and-opportunities-for-data-integration
#2
REVIEW
Teresa J Clark, Colleen A Friel, Emily Grman, Yair Shachar-Hill, Maren L Friesen
Nutritional mutualisms are ancient, widespread, and profoundly influential in biological communities and ecosystems. Although much is known about these interactions, comprehensive answers to fundamental questions, such as how resource availability and structured interactions influence mutualism persistence, are still lacking. Mathematical modelling of nutritional mutualisms has great potential to facilitate the search for comprehensive answers to these and other fundamental questions by connecting the physiological and genomic underpinnings of mutualisms with ecological and evolutionary processes...
July 25, 2017: Ecology Letters
https://www.readbyqxmd.com/read/28743155/neoadjuvant-chemotherapy-prior-to-radical-cystectomy-for-muscle-invasive-bladder-cancer-with-variant-histology
#3
Malte W Vetterlein, Stephanie A M Wankowicz, Thomas Seisen, Richard Lander, Björn Löppenberg, Felix K-H Chun, Mani Menon, Maxine Sun, Justine A Barletta, Toni K Choueiri, Joaquim Bellmunt, Quoc-Dien Trinh, Mark A Preston
BACKGROUND: Neoadjuvant chemotherapy in pure urothelial bladder cancer provides a significant survival benefit. However, to the authors' knowledge, it is unknown whether this benefit persists in histological variants. The objective of the current study was to assess the effect of neoadjuvant chemotherapy on the probability of non-organ-confined disease and overall survival after radical cystectomy (RC) in patients with histological variants. METHODS: Querying the National Cancer Data Base, the authors identified 2018 patients with histological variants who were undergoing RC for bladder cancer between 2003 and 2012...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28743081/mycobacterium-tuberculosis-ppe44-rv2770c-is-involved-in-response-to-multiple-stresses-and-promotes-the-macrophage-expression-of-il-12-p40-and-il-6-via-the-p38-erk-and-nf-%C3%AE%C2%BAb-signaling-axis
#4
Zhaoxiao Yu, Chenhui Zhang, Mingliang Zhou, Qiming Li, Hui Li, Wei Duan, Xue Li, Yonghong Feng, Jianping Xie
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a formidable threat to global public health. The successful intracellular persistence of M. tuberculosis significantly contributes to the intractability of tuberculosis. Proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) are mycobacterial exclusive protein families that widely reported to be involved in the bacterial virulence, physiology and interaction with host. Rv2770c (PPE44), a predicted virulence factor, was up-regulated upon the infected guinea pig lungs...
July 22, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28743034/therapeutic-advances-in-musculoskeletal-aav-targeting-approaches
#5
REVIEW
Karen Bulaklak, Xiao Xiao
The use of recombinant adeno-associated viruses (rAAVs) is highly prevalent in musculoskeletal gene therapies due to their versatility, high transduction efficiency, natural tropism and vector genome persistence for years. As the largest organ in the body, treatment of skeletal muscle for widespread and sufficient therapeutic gene expression is highly challenging. In addition to disease-specific hurdles, vector genome loss, off-target gene transfer and immune responses to treatment can diminish the overall benefit of rAAV therapies...
July 22, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28742939/disparate-peroxisome-related-defects-in-arabidopsis-pex6-and-pex26-mutants-link-peroxisomal-retrotranslocation-and-oil-body-utilization
#6
Kim L Gonzalez, Wendell A Fleming, Yun-Ting Kao, Zachary J Wright, Savina V Venkova, Meredith J Ventura, Bonnie Bartel
Catabolism of fatty acids stored in oil bodies is essential for Arabidopsis seed germination and seedling development. This fatty acid breakdown occurs in peroxisomes, organelles that sequester oxidative reactions. Import of peroxisomal enzymes is facilitated by peroxins including PEX5, a receptor that delivers cargo proteins from the cytosol to the peroxisomal matrix. After cargo delivery, a complex of the PEX1 and PEX6 ATPases and the PEX26 tail-anchored membrane protein removes ubiquitinated PEX5 from the peroxisomal membrane...
July 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28742864/limited-grounding-line-advance-onto-the-west-antarctic-continental-shelf-in-the-easternmost-amundsen-sea-embayment-during-the-last-glacial-period
#7
Johann P Klages, Gerhard Kuhn, Claus-Dieter Hillenbrand, James A Smith, Alastair G C Graham, Frank O Nitsche, Thomas Frederichs, Patrycja E Jernas, Karsten Gohl, Lukas Wacker
Precise knowledge about the extent of the West Antarctic Ice Sheet (WAIS) at the Last Glacial Maximum (LGM; c. 26.5-19 cal. ka BP) is important in order to 1) improve paleo-ice sheet reconstructions, 2) provide a robust empirical framework for calibrating paleo-ice sheet models, and 3) locate potential shelf refugia for Antarctic benthos during the last glacial period. However, reliable reconstructions are still lacking for many WAIS sectors, particularly for key areas on the outer continental shelf, where the LGM-ice sheet is assumed to have terminated...
2017: PloS One
https://www.readbyqxmd.com/read/28742825/impact-of-maternal-and-neonatal-health-initiatives-on-inequity-in-maternal-health-care-utilization-in-bangladesh
#8
Mohammad Rifat Haider, Mohammad Masudur Rahman, Md Moinuddin, Ahmed Ehsanur Rahman, Shakil Ahmed, M Mahmud Khan
BACKGROUND: Despite remarkable progress in maternal and child health, inequity persists in maternal care utilization in Bangladesh. Government of Bangladesh (GOB) with technical assistance from United Nation Population Fund (UNFPA), United Nation Children's Fund (UNICEF) and World Health Organization (WHO) started implementing Maternal and Neonatal Health Initiatives in selected districts of Bangladesh (MNHIB) in 2007 with an aim to reduce inequity in healthcare utilization. This study examines the effect of MNHIB on inequity in maternal care utilization...
2017: PloS One
https://www.readbyqxmd.com/read/28742777/lack-of-association-between-the-use-of-nerve-blockade-and-the-risk-of-persistent-opioid-use-among-patients-undergoing-shoulder-arthroplasty-evidence-from-the-marketscan-database
#9
Kathryn G Mueller, Stavros G Memtsoudis, Edward R Mariano, Laurence C Baker, Sean Mackey, Eric C Sun
BACKGROUND: Persistent opioid use following surgery has received increasing attention from policymakers, researchers, and clinicians. Perioperative nerve blockade has been hypothesized to decrease the risk of persistent opioid use. We examined whether nerve blockade was associated with a decreased risk of persistent opioid use among patients undergoing shoulder arthroplasty, a procedure with high rates of persistent postoperative pain. METHODS: Using health care claims data, we constructed a sample of 6695 patients undergoing shoulder arthroplasty between 2002 and 2012 and used billing data to identify the utilization of nerve blockade...
July 21, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28742747/a-50-year-old-man-with-persistent-hiccups
#10
Terence Potter, Vanessa Banks
No abstract text is available yet for this article.
August 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28742743/expanding-the-role-of-pas-in-the-treatment-of-severe-and-persistent-mental-illness
#11
Ben McCutchen, Sujay Patel, Dawn Copeland
Patients with severe and persistent mental illness often face limited access to psychiatric and primary care. This exploratory qualitative analysis studied the effect of introducing a PA into a comprehensive outpatient psychiatric team. Early results suggest this model improves the quality and access to primary and psychiatric care.
August 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28742738/necrotizing-enterocolitis-current-concepts-in-practice
#12
Alysia Agnoni, Christine Lazaros Amendola
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants and continues to be a major cause of morbidity and mortality. The incidence of NEC as well as mortality from the disease has persisted at unacceptably high levels for decades as current understanding of the cause remains incomplete. Identifying infants at risk and preventing NEC are mainstays of care. This article briefly examines disease presentation and treatment, identifies gaps in current understanding of disease pathology, and highlights new research that may lead to a decrease in the incidence of NEC in the future...
August 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28742704/racial-ethnic-disparities-in-longer-term-outcomes-among-emergency-general-surgery-patients-the-unique-experience-of-universally-insured-older-adults
#13
Cheryl K Zogg, Wei Jiang, Taylor D Ottesen, Shahid Shafi, Kevin Schuster, Robert Becher, Kimberly A Davis, Adil H Haider
OBJECTIVES: To determine whether racial/ethnic disparities in 30/90/180-day mortality, major morbidity, and unplanned readmissions exist among universally insured older adult (≥65 years) emergency general surgery patients; vary by diagnostic category; and can be explained by variations in geography, teaching status, age-cohort, and a hospital's percentage of minority patients. SUMMARY OF BACKGROUND DATA: As the US population ages and discussions surrounding the optimal method of insurance provision increasingly enter into national debate, longer-term outcomes are of paramount concern...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742649/thoracoscopic-implantation-of-an-array-electrode-in-the-pericardium-transverse-sinus-to-reduce-defibrillation-threshold
#14
Antonio Curnis, Claudio Muneretto, Gianluigi Bisleri, Manuel Cerini, Lorenza Inama, Francesca Salghetti, Raffaella De Vito, Laura Giroletti, Fabrizio Rosati, Daniele Giacopelli, Francesca Vassanelli, Luca Bontempi
Among the implantable cardioverter defibrillator recipients, there is still a subgroup of patients in whom the defibrillation threshold is too high and the maximal shock output of the implantable cardioverter defibrillator can fail to terminate a ventricular arrhythmia. We report a new thoracoscopic minimally invasive approach to place a standard array electrode in the transverse pericardial sinus of a patient implanted with a cardiac resynchronization and defibrillation therapy device with persistent high defibrillation threshold...
July 25, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28742591/sonographic-tips-for-evaluation-of-adnexal-masses-in-pregnancy
#15
Timothy P Canavan
Pregnancy is frequently a women's first contact with the health care system and often her first pelvic ultrasound examination. This first sonogram can reveal previously unknown adnexal pathology. Approximately 4% of pregnant women will have an adnexal mass detected by sonography and 1% to 2% of these masses will persist. It is estimated that up to 7% of these persistent masses will be malignant. Sonography plays an important role in differentiating benign from malignant adnexal masses and physiological from pathologic masses and should be used judiciously to complement evaluation and help guide treatment...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742580/surgery-and-endometriosis
#16
Austin Zanelotti, Alan H Decherney
Care of the endometriosis patient today can be complex and difficult. Once medical management has been exhausted and symptoms persist patients desire further treatment options. This chapter takes an evidence-based approach at discussion of patient surgcical options for treatment of endometriosis symptoms. Surgical techniques, success rates, patient satisfaction, and risks must be discussed and understood at depth before planning patient surgical intervention. This chapter provides reference to current surgical management options and symptom relief following those interventions...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742509/persistent-m%C3%A3-llerian-duct-syndrome-a-novel-mutation-in-the-%C3%AE-nti-m%C3%A3-llerian-%C3%AE-ormone-gene
#17
Ayça Altincik, Fahri Karaca, Hüseyin Onay
BACKGROUND AND OBJECTIVE: Persistent Müllerian duct syndrome (PMDS) is a relatively rare form of 46,XY disorder of sex development caused by the failure of formation, release or action of anti-Müllerian hormone (AMH) in intrauterine life. In this report we describe a case diagnosed with PMDS with a novel homozygous mutation in the AMH gene. CASE REPORT: A 4-month-old male presented with bilateral cryptorchidism and normal external genitalia. The laboratory examination revealed normal gonadotropin levels for his age (FSH: 0...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28742422/virus-isolation-and-molecular-detection-of-bluetongue-and-epizootic-hemorrhagic-disease-viruses-from-naturally-infected-white-tailed-deer-odocoileus-virginianus
#18
Clara Kienzle, Rebecca L Poulson, Mark G Ruder, David E Stallknecht
Hemorrhagic disease in North America is caused by multiple serotypes of epizootic hemorrhagic disease virus (EHDV) and bluetongue virus (BTV). Diagnostic tests for detection of EHDV and BTV include virus isolation (VI), reverse transcriptase polymerase chain reaction (RT-PCR), and real-time RT-PCR (rRT-PCR). Our objective was to compare the diagnostic capabilities of three rRT-PCR protocols for detection of EHDV and BTV from naturally infected white-tailed deer (Odocoileus virginianus). We compared the effectiveness of these assays to traditional viral detection methods (e...
July 25, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28742240/role-of-tissue-eosinophils-in-chronic-rhinosinusitis-associated-olfactory-loss
#19
Leah J Hauser, Rakesh K Chandra, Ping Li, Justin H Turner
BACKGROUND: Olfactory dysfunction is 1 of the hallmark symptoms of chronic rhinosinusitis (CRS). Eosinophilic inflammation has been implicated as a potential causative factor. However, prior studies have been limited by retrospective study designs, concomitant use of systemic corticosteroids, and other confounding factors. METHODS: CRS and healthy non-CRS control subjects undergoing endoscopic sinus or skull-base surgery were prospectively enrolled and completed olfactory testing utilizing the 40-item Smell Identification Test (SIT) immediately prior to surgery...
July 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28742145/survival-analysis-of-conservative-vs-dialysis-treatment-of-elderly-patients-with-ckd-stage-5
#20
Roman Reindl-Schwaighofer, Alexander Kainz, Michael Kammer, Alexandra Dumfarth, Rainer Oberbauer
Elderly patients represent a growing population among people suffering from ESRD. So far only limited data on actual survival benefits of elderly adults initiating dialysis have been published. Besides the high burden of preexisting comorbidities, dialysis treatment itself may be associated with a further deterioration in functional status in this population. We retrospectively analyzed the Austrian Dialysis and Transplant Registry and identified 8,622 patients who started maintenance hemodialysis after the age of 65 years between 2002 and 2009...
2017: PloS One
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