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https://www.readbyqxmd.com/read/29783191/ganga-water-pollution-a-potential-health-threat-to-inhabitants-of-ganga-basin
#1
REVIEW
Sanjay Dwivedi, Seema Mishra, Rudra Deo Tripathi
BACKGROUND: The water quality of Ganga, the largest river in Indian sub-continent and life line to hundreds of million people, has severely deteriorated. Studies have indicated the presence of high level of carcinogenic elements in Ganga water. OBJECTIVES: We performed extensive review of sources and level of organic, inorganic pollution and microbial contamination in Ganga water to evaluate changes in the level of various pollutants in the recent decade in comparison to the past and potential health risk for the population through consumption of toxicant tainted fishes in Ganga basin...
May 18, 2018: Environment International
https://www.readbyqxmd.com/read/29783177/evaluating-long-term-patterns-of-decreasing-groundwater-discharge-through-a-lake-bottom-permeable-reactive-barrier
#2
Timothy D McCobb, Martin A Briggs, Denis R LeBlanc, Frederick D Day-Lewis, Carole D Johnson
Identifying and quantifying groundwater exchange is critical when considering contaminant fate and transport at the groundwater/surface-water interface. In this paper, areally distributed temperature and point seepage measurements are used to efficiently assess spatial and temporal groundwater discharge patterns through a glacial-kettle lakebed area containing a zero-valent iron permeable reactive barrier (PRB). Concern was that the PRB was becoming less permeable with time owing to biogeochemical processes within the PRB...
May 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29783162/a-peripheral-immune-response-to-remembering-trauma-contributes-to-the-maintenance-of-fear-memory-in-mice
#3
Matthew B Young, Leonard L Howell, Lauren Hopkins, Cassandra Moshfegh, Zhe Yu, Lauren Clubb, Jessica Seidenberg, Jeanie Park, Adam P Swiercz, Paul J Marvar
Alterations in peripheral immune markers are observed in individuals with post-traumatic stress disorder (PTSD). PTSD is characterized in part by impaired extinction of fear memory for a traumatic experience. We hypothesized that fear memory extinction is regulated by immune signaling stimulated when fear memory is retrieved. The relationship between fear memory and the peripheral immune response was tested using auditory Pavlovian fear conditioning in mice. Memory for the association was quantified by the amount of conditioned freezing exhibited in response to the conditioned stimulus (CS), extinction and time-dependent changes in circulating inflammatory cytokines...
May 17, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29783158/pirfenidone-ameliorates-lipopolysaccharide-induced-pulmonary-inflammation-and-fibrosis-by-blocking-nlrp3-inflammasome-activation
#4
Yi Li, Haitao Li, Shuai Liu, Pinhua Pan, Xiaoli Su, Hongyi Tan, Dongdong Wu, Lemeng Zhang, Chao Song, Minhui Dai, Qian Li, Zhi Mao, Yuan Long, Yongbin Hu, Chengping Hu
Acute respiratory distress syndrome(ARDS)is a severe clinical disorder characterized by its acute onset, diffuse alveolar damage, intractable hypoxemia, and non-cardiogenic pulmonary edema. Acute lung injury(ALI) can trigger persistent lung inflammation and fibrosis through activation of the NLRP3 inflammasome and subsequent secretion of mature IL-1β, suggesting that the NLRP3 inflammasome is a potential therapeutic target for ALI, for which new therapeutic approaches are needed. Our present study aims to assess whether pirfenidone,with anti-fibrotic and anti-inflammatory properties, can improve LPS-induced inflammation and fibrosis by inhibiting NLRP3 inflammasome activation...
May 18, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29783117/changes-in-soil-nitrogen-dynamics-caused-by-prescribed-fires-in-dense-gorse-lands-in-sw-pyrenees
#5
Leire Múgica, Rosa M Canals, Leticia San Emeterio
Rural depopulation, abandonment of traditional land uses and decrease of extensive stockfarming is accelerating shrub encroachment in mountain areas. In NW Spain, gorse (Ulex gallii Planch.) is expanding, developing dense shrublands that accumulate high fuel-loads, ignite easily and persist during long periods as alternate stable states. Under this scenario, traditional bush-to-bush farming fires are being replaced by high fuel-load burnings performed by specialised teams to reduce fuels and promote mosaic landscapes...
May 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29783108/a-new-perspective-to-aberrations-caused-by-barium-and-vanadium-ions-on-lens-culinaris-medik
#6
Murat Çanlı
This study investigates aberrations caused by barium and vanadium on meristematic cells of Lens culinaris Medik. Barium and vanadium ions at various concentrations (0.05 M, 0.1 M, 0.25 M, 0.5 M, and 1.0 M) were exposed to the seeds of the plant at fixed time interval (12 h). After seedlings, with a microscopic examination images were captured about the root tips. Those images showed that several abnormalities occurred on the plant such as chromosome breakings, chromosome dispersion, bridge chromosome, chromosome adherence, ring chromosome...
May 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29783094/the-relation-of-parent-alcohol-disorder-to-young-adult-drinking-outcomes-mediated-by-parenting-effects-of-developmentally-limited-versus-persistent-parent-alcohol-disorder
#7
Ariel Sternberg, Danielle Pandika, Kit K Elam, Laurie Chassin
BACKGROUND: Parent alcohol use disorder (AUD) is a well-established risk factor for the development of offspring AUD and is associated with poor parenting. However, few studies have examined heterogeneity in trajectories of parental AUD and its influence on adolescent offspring drinking, and no studies to date have considered the differential risk to offspring conferred by parental AUDs that are limited to early adulthood. Specifically, AUDs limited to the period of emerging adulthood may confer less risk to a child's environment as recovery following emerging adulthood coincides with the typical ages of entry into the parenting role...
April 25, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29783084/organochlorine-pesticides-ocps-and-polychlorinated-biphenyls-pcbs-in-cyprinidae-fish-towards-hints-of-their-arrangements-using-advanced-classification-methods
#8
Snježana Herceg Romanić, Gordana Vuković, Darija Klinčić, Marijana Matek Sarić, Ivan Župan, Davor Antanasijević, Aleksandar Popović
To tackle the ever-present global concern regarding human exposure to persistent organic pollutants (POPs) via food products, this study strived to indicate associations between organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in lake-fish tissue depending on the species and sampling season. Apart from the monitoring initiatives recommended in the Global Monitoring Plan for POPs, the study discussed 7 OCPs and 18 PCB congeners determined in three Cyprinidae species (rudd, carp, and Prussian carp) from Vransko Lake (Croatia), which are widely domesticated and reared as food fish across Europe and Asia...
May 18, 2018: Environmental Research
https://www.readbyqxmd.com/read/29783006/technique-of-whole-sellar-stereotactic-radiosurgery-for-cushing-s-disease-results-from-a-multicenter-international-cohort-study
#9
Matthew J Shepard, Gautam U Mehta, Zhiyuan Xu, Hideyuki Kano, Nathaniel Sisterson, Yan-Hua Su, Michal Krsek, Ahmed M Nabeel, Amr El-Shehaby, Khaled A Kareem, Nuria Martinez-Moreno, David Mathieu, Brendan J McShane, Kevin Blas, Douglas Kondziolka, Inga Grills, John Y Lee, Roberto Martinez-Alvarez, Wael A Reda, Roman Liscak, Cheng-Chia Lee, L Dade Lunsford, Mary Lee Vance, Jason P Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) is used to manage patients with Cushing's disease (CD) who have failed surgical/medical management. As many patients with recurrent/persistent CD lack an identifiable adenoma on neuro-imaging, whole-sellar SRS has been increasingly employed. We therefore sought to define the outcomes of patients undergoing whole-sellar SRS. METHODS: An international, multicenter, retrospective cohort-design was used to define clinical/endocrine outcomes for patients undergoing whole-sellar SRS for CD...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29782928/a-mathematical-approach-to-effects-of-ctls-on-cancer-virotherapy-in-the-second-injection-of-virus
#10
A Ashyani, O RabieiMotlagh, H M Mohammadinezhad
This paper proposes a planar delay differential equation for cancer virotherapy. The model simulates the situation in which an oncolytic virus is injected for the second time, and the immune system suppresses the viral infection with a time delay. Our purpose is to provide theoretical conditions so that the therapy can be continued successfully. With the help of the characteristic equation, we examine the singularities and their local stability. Hopf bifurcation is also investigated around the endemic singularity...
May 18, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29782908/deficits-in-temporal-order-memory-induced-by-interferon-alpha-ifn-%C3%AE-treatment-are-rescued-by-aerobic-exercise
#11
Sally Barlow, Briana Fahey, Kimberley J Smith, Johannes Passecker, Andrea Della-Chiesa, Vincent Hok, Jennifer S Day, Charlotte K Callaghan, Shane M O'Mara
Patients receiving cytokine immunotherapy with IFN-α frequently present with neuropsychiatric consequences and cognitive impairments, including a profound depressive-like symptomatology. While the neurobiological substrates of the dysfunction that leads to adverse events in IFN-α-treated patients remains ill-defined, dysfunctions of the hippocampus and prefrontal cortex (PFC) are strong possibilities. To date, hippocampal deficits have been well-characterised; there does however remain a lack of insight into the nature of prefrontal participation...
May 18, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29782843/role-of-nutritional-vitamin-d-in-osteoporosis-treatment
#12
REVIEW
Yi-Chou Hou, Chia-Chao Wu, Min-Tser Liao, Jia-Fwu Shyu, Chi-Feng Hung, Tzung-Hai Yen, Chien-Lin Lu, Kuo-Cheng Lu
Osteoporosis is a systemic skeletal disorder characterized by a decrease in bone mass and microarchitectural deterioration of bone tissue. The World Health Organization has defined osteoporosis as a decrease in bone mass (50%) and bony quality (50%). Vitamin D, a steroid hormone, is crucial for skeletal health and in mineral metabolism. Its direct action on osteoblasts and osteoclasts and interaction with nonskeletal tissues help in maintaining a balance between bone turnover and bone growth. Vitamin D affects the activity of osteoblasts, osteoclasts, and osteocytes, suggesting that it affects bone formation, bone resorption, and bone quality...
May 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29782834/high-throughput-dissection-of-aav-host-interactions-the-fast-and-the-curious
#13
REVIEW
Anne-Kathrin Herrmann, Dirk Grimm
Over fifty years after its initial description, Adeno-associated virus (AAV) remains a most exciting but also most elusive study object in basic or applied virology. On the one hand, its simple structure not only facilitates investigations into virus biology, but combined with the availability of numerous natural AAV variants with distinct infection efficiency and specificity also makes AAV a preferred substrate for engineering of gene delivery vectors. On the other hand, it is striking to witness a recent flurry of reports that highlight and partially close persistent gaps in our understanding of AAV virus and vector biology...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29782816/a-new-microsporidium-apotaspora-heleios-n-g-n-sp-from-the-riverine-grass-shrimp-palaemonetes-paludosus-decapoda-caridea-palaemonidae
#14
Yuliya Y Sokolova, Robin M Overstreet
We report a new microsporidium from a key species of the estuarine communities of the Gulf States, the Riverine grass shrimp, Palaemonetes paludosus. A milky-white shrimp was found in the Mobile Bay Delta, a large, oligohaline-freshwater wetland in Alabama, USA. Light microscopy of smears and thick sections of the abdominal tissues demonstrated infection with microsporidian spores enclosed in sporophorous vesicles (SVs) in sets of eight. Broadly oval spores measured 2.9 ± 0.06 x 1.7 ± 0.03 µm (2.5-3.3 x 1...
May 18, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29782655/cross-scale-occupancy-dynamics-of-a-post-fire-specialist-in-response-to-variation-across-a-fire-regime
#15
Morgan W Tingley, Andrew N Stillman, Robert L Wilkerson, Christine A Howell, Sarah C Sawyer, Rodney B Siegel
1.Fire creates challenges and opportunities for wildlife through rapid destruction, modification, and creation of habitat. Fire has spatially variable effects on landscapes, however, and for species that benefit from the ephemeral resource patches created by fire, it is critical to understand characteristics of fires that promote post-fire colonization and persistence, and the spatial scales on which they operate. 2.Using a model post-fire specialist, the black-backed woodpecker (Picoides arcticus), we examined how colonization and persistence varied across two spatial scales as a function of four characteristics of fire regimes - fire severity, fire size, fire ignition date, and number of years since fire...
May 21, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29782592/the-role-of-hybrid-bone-spect-ct-imaging-in-the-work-up-of-the-limping-patient-a-symptom-based-and-joint-oriented-review
#16
REVIEW
H K Mohan, K Strobel, W van der Bruggen, G Gnanasegaran, W U Kampen, T Kuwert, T Van den Wyngaert, F Paycha
A vast spectrum of lower limb bone and joint disorders (hip, knee, ankle, foot) present with a common clinical presentation: limping. Too often this symptom generates an inefficient cascade of imaging studies. This review attempts to optimise the diagnostic effectiveness of bone scintigraphy using the hybrid SPECT/CT technique in relation to the diagnostic clues provided by other imaging modalities, discusses the appropriate clinical indications, optimal scintigraphic procedures and illustrates updated image pattern-oriented reporting...
2018: Eur J Hybrid Imaging
https://www.readbyqxmd.com/read/29782500/the-human-snail-transmission-environment-shapes-long-term-schistosomiasis-control-outcomes-implications-for-improving-the-accuracy-of-predictive-modeling
#17
David Gurarie, Nathan C Lo, Martial L Ndeffo-Mbah, David P Durham, Charles H King
INTRODUCTION: Schistosomiasis is a chronic parasitic trematode disease that affects over 240 million people worldwide. The Schistosoma lifecycle is complex, involving transmission via specific intermediate-host freshwater snails. Predictive mathematical models of Schistosoma transmission have often chosen to simplify or ignore the details of environmental human-snail interaction in their analyses. Schistosome transmission models now aim to provide better precision for policy planning of elimination of transmission...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29782361/the-significance-of-para-aortic-nodal-size-and-the-role-of-adjuvant-systemic-chemotherapy-in-cervical-cancer-an-institutional-experience
#18
Dustin B Manders, Travis T Sims, April Bailey, Lindsay Hwang, Debra L Richardson, David S Miller, Siobhan M Kehoe, Kevin V Albuquerque, Jayanthi S Lea
OBJECTIVE: Cervical cancer metastatic to the para-aortic lymph nodes (PALNs) carries a poor prognosis. Despite extended-field radiation therapy (EFRT), only 30% to 50% of patients will survive 3 years. We sought to examine the treatment regimens used, associated toxicities, and treatment outcomes in patients with cervical cancer metastatic to PALN. METHODS: A retrospective review was performed of all patients with cervical cancer treated at a single institution between January 1, 2007 and November 1, 2014...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29782289/-the-effect-of-changing-of-conventional-antihypertensive-therapy-to-a-triple-fixed-combination-therapy-with-rosuvastatin-in-high-cardiovascular-risk-patients
#19
F T Ageev, Z N Blankova, N S Samsonova
BACKGROUND: The low efficiency of recommended therapy for reducing cardiovascular risk (CV) in patients with arterial hypertension even with an effective blood pressure decrease is often due to the persistence of high blood cholesterol and arterial stiffness. Among the effective ways to achieve the goal of therapy is considered the changing to a single-pill combinations (SPCs) of two antihypertensive drugs and statin. AIM: To assess influence of fixed combination consisted of amlodipine, lisinopril and rosuvastatin to the dynamic of lipid spectrum, blood pressure level and elastic properties of arteries in patients with arterial hypertension and high risk of cardio-vascular complications being transferred from their preceding antihypertensive therapy...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782228/participation-retention-and-utilization-of-a-web-based-chronic-disease-self-management-intervention-among-older-adults
#20
Jennifer Dickman Portz, Walter F LaMendola
BACKGROUND: Web-based self-management (web-based SM) interventions provide a potential resource for older adults to engage in their own chronic disease management. The purpose of this study is to investigate the effect of age on participation, retention, and utilization of a web-based SM intervention. MATERIALS AND METHODS: This study reports the results of a secondary data analysis of the effects of age in a randomized trial of a web-based diabetes SM intervention...
May 21, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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