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https://www.readbyqxmd.com/read/29353086/ruthenium-dendrimers-as-carriers-for-anticancer-sirna
#1
Sylwia Michlewska, Maksim Ionov, Marta Maroto-Díaz, Aleksandra Szwed, Aliaksei Ihnatsyeu-Kachan, Svetlana Loznikova, Dzmitry Shcharbin, Marek Maly, Rafael Gomez Ramirez, Francisco Javier de la Mata, Maria Bryszewska
Dendrimers, which are considered as one of the most promising tools in the field of nanobiotechnology due to their structural organization, showed a great potential in gene therapy, drug delivery, medical imaging and as antimicrobial and antiviral agents. This article is devoted to study interactions between new carbosilane-based metallodendrimers containing ruthenium and anti-cancer small interfering RNA (siRNA). Formation of complexes between anti-cancer siRNAs and Ru-based carbosilane dendrimers was evaluated by transmission electron microscopy, circular dichroism and fluorescence...
January 12, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29338193/induction-of-chirality-in-two-dimensional-nanomaterials-chiral-2d-mos2-nanostructures
#2
Finn Purcell-Milton, Robert McKenna, Lorcan Brennan, Conor P Cullen, Lilian Guillemeney, Nikita V Tepliakov, Anvar S Baimuratov, Ivan D Rukhlenko, Tatiana S Perova, Georg S Duesberg, Alexander V Baranov, Anatoly V Fedorov, Yurii K Gun'ko
Two-dimensional (2D) nanomaterials have been intensively investigated due to their interesting properties and range of potential applications. Although most research has focused on graphene, atomic layered transition metal dichalcogenides (TMDs) and particularly MoS2 have gathered much deserved attention recently. Here we report the induction of chirality into 2D chiral nanomaterials by carrying out liquid exfoliation of MoS2 in the presence of chiral ligands (cysteine and penicillamine) in water. This processing resulted in exfoliated chiral 2D MoS2 nanosheets showing strong circular dichroism (CD) signals, which were far past the onset of the original chiral ligand signals...
January 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29332574/biomacromolecular-based-fibers-in-nanomedicine-a-combination-of-drug-delivery-and-tissue-engineering
#3
Elham Arkan, Abbas Hemati Azandaryani, Pouran Moradipour, Leila Behbood
BACKGROUND: Biopolymers based materials (polysaccharides, lipids, proteins, and nucleic acids) are one of the basic resources in bio-engineering sciences because of desirable features. Moreover, nanobiotechnology innovates nanomaterial and associated technique in nano medicine (drug delivery and tissue engineering). METHODS: In the nano-medicine, fibers are introduced as a successful biomimetic extracellular matrix scaffolds and drug carrier systems. Electrospinning as a simple and cost-effective technique is used to design nanofibers...
January 12, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29320893/the-current-status-of-non-viral-vectors-for-gene-therapy-in-china
#4
Li Liu, Jingyun Yang, Ke Men, Zhi-Yao He, Min Luo, Zhi-Yong Qian, Xiawei Wei
With the growing interest in the application of non-viral vectors for drug delivery, diagnosis and imaging, progress has been made in the field of non-viral vector gene therapy in China. Studies on nanobiotechnology are important in the development plan of China in 21st century research priorities. The National 973 Plan and "Strategic Priority Research Program" classify nanobiotechnology as a special project and give priority to supporting its development. From 2000 to 2017, many articles on non-viral vector gene therapy were published...
January 10, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29283225/label-free-imaging-of-nanoparticle-uptake-competition-in-single-cells-by-hyperspectral-stimulated-raman-scattering
#5
Bin Huang, Shuai Yan, Lin Xiao, Rong Ji, Liuyan Yang, Ai-Jun Miao, Ping Wang
Imaging and quantification of nanoparticles in single cells in their most natural condition are expected to facilitate the biotechnological applications of nanoparticles and allow for better assessment of their biosafety risks. However, current imaging modalities either require tedious sample preparation or only apply to nanoparticles with specific physicochemical characteristics. Here, the emerging hyperspectral stimulated Raman scattering (SRS) microscopy, as a label-free and nondestructive imaging method, is used for the first time to investigate the subcellular distribution of nanoparticles in the protozoan Tetrahymena thermophila...
December 28, 2017: Small
https://www.readbyqxmd.com/read/29278303/virus-based-nanoparticles-of-simian-virus-40-in-the-field-of-nanobiotechnology
#6
REVIEW
Wenjing Zhang, Xian-En Zhang, Feng Li
Biomolecular nanostructures derived from living organisms, such as protein cages, fibers and layers are drawing increasing interests as natural biomaterials. The virus-based nanoparticles (VNPs) of simian virus 40 (SV40), with a cage-like structure assembled from the major capsid protein of SV40, have been developed as a platform for nanobiotechnology in the recent decade. Foreign nanomaterials (e.g. quantum dots (QDs) and gold nanoparticles (AuNPs)) can be positioned in the inner cavity or on the outer surface of SV40 VNPs, through self-assembly by engineering the nanoparticle (NP)-protein interfacial interactions...
December 26, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29241293/in-vivo-delivery-of-nanoparticles-into-plant-leaves
#7
Honghong Wu, Israel Santana, Joshua Dansie, Juan P Giraldo
Plant nanobiotechnology is an interdisciplinary field at the interface of nanotechnology and plant biology that aims to utilize nanomaterials as tools to study, augment or impart novel plant functions. The delivery of nanoparticles to plants in vivo is a key initial step to investigate plant nanoparticle interactions and the impact of nanoparticles on plant function. Quantum dots are smaller than plant cell wall pores, have versatile surface chemistry, bright fluorescence and do not photobleach, making them ideal for the study of nanoparticle uptake, transport, and distribution in plants by widely available confocal microscopy tools...
December 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/29198119/synthesis-of-fluorescent-au-nanocrystals-silica-hybrid-nanocomposite-flash-with-enhanced-optical-features-for-bio-imaging-and-photodynamic-activity
#8
Taeshik Kim, Hongje Jang, Seongchan Kim, Jong-Hwan Lee, Sung-Yon Kim, Noo Li Jeon, Joon Myong Song, Dal-Hee Min
Fluorescent Au nanocrystals-silica hybrid nanocomposite (FLASH) was synthesized by co-condensation of surface modified Au nanocrystals (AuNCs). Present FLASH nanocomposite exhibited 4 times enhanced photoluminescence and photocatalytic activity compared to single nanocrystals. Based on these enhanced optical features, we successfully demonstrated in vitro fluorescence bio-imaging of introduced FLASH to human cervical cancer cell line HeLa. Beyond the confirmation of photocatalytic activity from the photodegradation of methylene blue as model compound, regional selective photodynamic therapy of HeLa cells under the UV irradiation was also presented...
December 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29160704/nanobiotechnology-for-environment-innovative-solutions-for-the-management-of-harmful-algal-blooms
#9
Matthew Robert Gellert, Beum Jun Kim, Samuel Evan Reffsin, Sebastian Eureko Jusuf, Nicole Denise Wagner, Stephen Winans, Mingming Wu
Nanobiotechnology has played important roles in solving contemporary health problems including cancer and diabetes, but has not yet been widely exploited for problems in food security and environmental protection. Water scarcity is an emerging worldwide problem due to climate change and population increase. Current methods of managing water resources are not efficient or sustainable. In this perspective, we focus on harmful algal blooms to demonstrate how nanobiotechnology can be explored to understand microbe-environment interaction and allow for toxin/pollutant detection with significantly improved sensitivity...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29144399/dna-g-wire-formation-using-an-artificial-peptide-is-controlled-by-protease-activity
#10
Kenji Usui, Arisa Okada, Shungo Sakashita, Masayuki Shimooka, Takaaki Tsuruoka, Shu-Ichi Nakano, Daisuke Miyoshi, Tsukasa Mashima, Masato Katahira, Yoshio Hamada
The development of a switching system for guanine nanowire (G-wire) formation by external signals is important for nanobiotechnological applications. Here, we demonstrate a DNA nanostructural switch (G-wire <--> particles) using a designed peptide and a protease. The peptide consists of a PNA sequence for inducing DNA to form DNA-PNA hybrid G-quadruplex structures, and a protease substrate sequence acting as a switching module that is dependent on the activity of a particular protease. Micro-scale analyses via TEM and AFM showed that G-rich DNA alone forms G-wires in the presence of Ca(2+), and that the peptide disrupted this formation, resulting in the formation of particles...
November 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29131585/antibody-templated-assembly-of-an-rna-mimic-of-green-fluorescent-protein
#11
Alessandro Bertucci, Alessandro Porchetta, Francesco Ricci
One of the most intriguing ways through which Nature achieves regulation of biological pathways encompasses the coordination of non-covalent interactions that bring biomolecules to be co-localized in a designated restricted space. This nano-confinement leads to a drastic increase in the effective local concentration of the species involved, which ultimately triggers reactions that would otherwise not occur at the low concentrations found in cells. Inspired by this mechanism, we have explored the possibility of using antibodies as bivalent biomolecular substrates for the templated assembly of a functional RNA structure...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29117680/molecular-determinants-and-bottlenecks-in-the-dissociation-dynamics-of-biotin-streptavidin
#12
Pratyush Tiwary
Biotin-streptavidin is a very popular system used to gain insight into protein-ligand interactions. In its tetrameric form, it is well-known for its exceptionally high kinetic stability, being one of the strongest known noncovalent interactions in nature, and it is heavily used across the biotechnological industry. In this work, we gain understanding of the molecular determinants and bottlenecks in the dissociation of the dimeric biotin-streptavidin system in wild type and with a point mutation. Using recently proposed enhanced sampling methods with full atomistic resolution, we reproduce the experimentally reported effect of the mutation on the dissociation rate...
November 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29081048/solid-binding-peptides-in-biomedicine
#13
Andrew Care, Peter L Bergquist, Anwar Sunna
Some peptides are able to bind to inorganic materials such as silica and gold. Over the past decade, Solid-binding peptides (SBPs) have been used increasingly as molecular building blocks in nanobiotechnology. These peptides show selectivity and bind with high affinity to a diverse range of inorganic surfaces e.g. metals, metal oxides, metal compounds, magnetic materials, semiconductors, carbon materials, polymers and minerals. They can be used in applications such as protein purification and synthesis, assembly and the functionalization of nanomaterials...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29043857/magnetic-carbon-nanotubes-preparation-physical-properties-and-applications-in-biomedicine
#14
Mehrdad Samadishadlou, Masoud Farshbaf, Nasim Annabi, Taras Kavetskyy, Rovshan Khalilov, Siamak Saghfi, Abolfazl Akbarzadeh, Sepideh Mousavi
Magnetic carbon nanotubes (MCNTs) have been widely studied for their potential applications in medicine, diagnosis, cell biology, analytical chemistry, and environmental technology. Introduction of MCNTs paved the way for the emergence of new approaches in nanobiotechnology and biomedicine as a result of their multifarious properties embedded within either the carbon nanotubes (CNTs) or magnetic parts. Numerous preparation techniques exists for functionalizing CNTs with magnetic nanoparticles, and these versatile strategies lay the ground for the generation of novel and versatile systems which are applicable to many industries and biological areas...
October 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29025665/cell-attachment-evaluation-of-the-immobilized-bioactive-peptide-on-a-nanographene-oxide-composite
#15
Behzad Adibi-Motlagh, Abbas Sahebghadam Lotfi, Aram Rezaei, Ehsan Hashemi
The immobilization of bioactive peptides as key molecules in numerous biological and physiological functions holds promise for designing advanced biomaterials. Graphene and its derivatives, having unique physicochemical properties, have brought considerable attention in the life sciences. In this regard, the chemical manipulation of the graphene surface with bioactive peptides opens a new horizon to design bioactive materials for a variety of future nanobiotechnologies. In this study, the first straightforward strategy for the covalent immobilization of the cell-adhesion peptide onto the graphene surface based on the Ugi four-component assembly process (Ugi 4-CAP) will be presented...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28965140/fungi-assisted-silver-nanoparticle-synthesis-and-their-applications
#16
REVIEW
Azhar U Khan, Nazia Malik, Masudulla Khan, Moo Hwan Cho, Mohammad Mansoob Khan
Nanotechnology is a rapidly developing field because of its wide range of applications in science, nanoscience and biotechnology. Nanobiotechnology deals with nanomaterials synthesised or modified using biotechnology. Fungi are used to synthesise metal nanoparticles and they have vast applications in wound healing, pathogen detection and control, food preservation, textiles, fabrics, etc. The present review describes the different types of fungi used for the biosyntheses of silver nanoparticles (AgNPs), along with their characterisation and possible biological applications...
September 30, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28952430/gold-nanoparticles-promising-agent-to-improve-the-diagnosis-and-therapy-of-cancer
#17
Limin Ning, Benwei Zhu, Tao Gao
BACKGROUND: Gold nanoparticles have been exploited for nanobiotechnology applications for the last two decades. New insights of the nanomaterials as promising agent for cancer diagnosis and therapy have just started to emerge. Due to the size- and shape-dependent optical, electrical and thermal properties, gold nanoparticles are being developed as diagnostic reagents, drug carriers, contrast agents, photothermal agents and radiosensitisers. OBJECTIVE: This review aims to summarize the latest advances of gold nanoparticles in cancer treatment...
September 25, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28926036/polymer-nanodiscs-and-macro-nanodiscs-of-a-varying-lipid-composition
#18
Venkata Sudheer Kumar Ramadugu, Giacomo Maria Di Mauro, Thirupathi Ravula, Ayyalusamy Ramamoorthy
Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to ∼60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties.
September 28, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28920693/ph-tunable-and-divalent-metal-ion-tolerant-polymer-lipid-nanodiscs
#19
Thirupathi Ravula, Nathaniel Z Hardin, Sudheer Kumar Ramadugu, Ayyalusamy Ramamoorthy
The development and applications of detergent-free membrane mimetics have been the focus for the high-resolution structural and functional studies on membrane proteins. The introduction of lipid nanodiscs has attracted new attention toward the structural biology of membrane proteins and also enabled biomedical applications. Lipid nanodiscs provide a native lipid bilayer environment similar to the cell membrane surrounded by a belt made up of proteins or peptides. Recent studies have shown that the hydrolyzed form of styrene maleic anhydride copolymer (SMA) has the ability to form lipid nanodiscs and has several advantages over protein or peptide based nanodiscs...
September 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28919741/extracellular-biosynthesis-of-silver-nanoparticles-using-the-cell-free-filtrate-of-nematophagous-fungus-duddingtonia-flagrans
#20
Laryssa Pinheiro Costa Silva, Jairo Pinto Oliveira, Wanderson Juvencio Keijok, André Romero da Silva, Anderson Rocha Aguiar, Marco Cesar Cunegundes Guimarães, Carolina Magri Ferraz, Jackson Victor Araújo, Fernando Luiz Tobias, Fábio Ribeiro Braga
The biosynthesis of metallic nanoparticles (NPs) using biological systems such as fungi has evolved to become an important area of nanobiotechnology. Herein, we report for the first time the extracellular synthesis of highly stable silver NPs (AgNPs) using the nematophagous fungus Duddingtonia flagrans (AC001). The fungal cell-free filtrate was analyzed by the Bradford method and 3,5-dinitrosalicylic acid assay and used to synthesize the AgNPs in the presence of a 1 mM AgNO3 solution. They have been characterized by UV-Vis spectroscopy, X-ray diffraction, transmission electron microscopy, dynamic light scattering, Zeta potential measurements, Fourier-transform infrared, and Raman spectroscopes...
2017: International Journal of Nanomedicine
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