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Paula Fraga-García, Peter Kubbutat, Markus Brammen, Sebastian Schwaminger, Sonja Berensmeier
Microalgae continue to gain in importance as a bioresource, while their harvesting remains a major challenge at the moment. This study presents findings on microalgae separation using low-cost, easy-to-process bare iron oxide nanoparticles with the additional contribution of the upscaling demonstration of this simple, adhesion-based process. The high affinity of the cell wall for the inorganic surface enables harvesting efficiencies greater than 95% for Scenedesmus ovalternus and Chlorella vulgaris . Successful separation is possible in a broad range of environmental conditions and primarily depends on the nanoparticle-to-microalgae mass ratio, whereas the effect of pH and ionic strength are less significant when the mass ratio is chosen properly...
May 1, 2018: Nanomaterials
Victoria Shipunova, Ivan Zelepukin, Oleg A Stremovskiy, Maxim Petrovich Nikitin, Andrew Care, Anwar Sunna, Andrei V Zvyagin, Sergey Mikhailovich Deyev
Nanoparticle surface engineering can change its chemical identity to enable surface-coupling with functional biomolecules. However, common surface coupling methods such as physical adsorption or chemical conjugation often suffer from the low coupling yield, poorly controllable orientation of biomolecules and steric hindrance during target binding. These issues limit the application scope of nanostructures for theranostics and personalized medicine. To address these shortfalls, we developed a rapid and versatile method of nanoparticle biomodification...
April 27, 2018: ACS Applied Materials & Interfaces
Flávia Sousa, Rui P Moura, Elias Moreira, Cláudia Martins, Bruno Sarmento
Glioblastoma multiforme (GBM) is the most common and challenging primary malignant brain tumor, being the median overall survival between 10 and 14 months due to its invasive characteristics. GBM treatment is mainly based on the maximal surgical resection and radiotherapy associated to chemotherapy. Monoclonal antibodies (mAbs) have been used in chemotherapy protocols for GBM treatment in order to improve immunotherapy and antiangiogenic processes. High specificity and affinity of mAbs for biological targets make them highly used for brain tumor therapy...
2018: Advances in Protein Chemistry and Structural Biology
Shizhu Chen, Xing-Jie Liang
No abstract text is available yet for this article.
April 1, 2018: Science China. Life Sciences
Sugam Kumar, Indresh Yadav, Vinod Kumar Aswal, Joachim Kohlbrecher
The integration of nanoparticles with proteins is of high scientific interest due to the amazing potential displayed by their complexes, combining the nanoscale properties of nanoparticles with the specific architectures and functions of the protein molecules. The nanoparticle-protein complexes, in particular, are useful in the emerging field of nanobiotechnology (nanomedicine, drug delivery and biosensors) as the nanoparticles having sizes comparable to that of living cells, can access and operate within the cell...
April 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Oliver Birkholz, Jonathan R Burns, Christian P Richter, Olympia E Psathaki, Stefan Howorka, Jacob Piehler
Synthetically replicating key biological processes requires the ability to puncture lipid bilayer membranes and to remodel their shape. Recently developed artificial DNA nanopores are one possible synthetic route due to their ease of fabrication. However, an unresolved fundamental question is how DNA nanopores bind to and dynamically interact with lipid bilayers. Here we use single-molecule fluorescence microscopy to establish that DNA nanopores carrying cholesterol anchors insert via a two-step mechanism into membranes...
April 18, 2018: Nature Communications
Livia Angeloni, Melania Reggente, Daniele Passeri, Marco Natali, Marco Rossi
Identification of nanoparticles and nanosystems into cells and biological matrices is a hot research topic in nanobiotechnologies. Because of their capability to map physical properties (mechanical, electric, magnetic, chemical, or optical), several scanning probe microscopy based techniques have been proposed for the subsurface detection of nanomaterials in biological systems. In particular, atomic force microscopy (AFM) can be used to reveal stiff nanoparticles in cells and other soft biomaterials by probing the sample mechanical properties through the acquisition of local indentation curves or through the combination of ultrasound-based methods, like contact resonance AFM (CR-AFM) or scanning near field ultrasound holography...
April 17, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Bhavana Sharma, Renu Deswal
A facile one-pot green synthesis of gold nanoparticles (AuNPs) with different geometries was achieved using an underutilized Himalayan bioresource Hippophae rhamnoides. Aqueous leaf (LE) and berry extracts (BE) showed rapid synthesis of monodispersed spherical LEAuNPs (27 ± 3.2 nm) and anisotropic BEAuNPs (55 ± 4.5 nm) within 2 and 15 min, respectively. The Fourier-transform infrared (FTIR) spectroscopy showed involvement of polyphenolics/flavonoids in AuNPs reduction. LE AuNPs (IC50 49 µg) exhibited higher antioxidant potential than BE AuNPs (IC50 57 µg)...
April 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
He Liu, Yue Gu, Tao Dong, Liuqing Yan, Xiaoyi Yan, Tingting Zhang, Nannan Lu, Zhiqian Xu, Haixin Xu, Zhiquan Zhang, Ting Bian
The combination of nanoparticles and biomarkers yields functional nanostructured biointerface, which is playing a notable role in biotechnology development. Due to the 5-fold twined structure in the Au-Pt star-shaped decahedra not only allowed it to act as efficient scaffold for immobilization of antibody, but it also exhibits superior electrocatalytic activity toward H2 O2 reduction, the nanocrystal as the efficient signal transduction label is first employed to construct an electrochemical immunosensor. Donor-π-Acceptor (D-π-A) linking fashion generates a dipolar push-pull system and assures superior intramolecular charge transfer...
March 13, 2018: Biosensors & Bioelectronics
Shweta D Dabhi, Basant Roondhe, Prafulla K Jha
Understanding the interactions between biomolecules and boron nitride nanostructures is key for their use in nanobiotechnology and medical engineering. In this study, we investigated the adsorption of nucleobases adenine (A), guanine (G), cytosine (C), thymine (T) and uracil (U) over armchair and zigzag boron nitride nanoribbons (BNNR) using density functional theory to define the applicability of BNNR for the sensing of nucleobases and DNA sequencing. To appropriately account for dispersion, the van der Waals forces (DFT-D2)-type method developed by Grimme was also included in the calculations...
March 28, 2018: Physical Chemistry Chemical Physics: PCCP
Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W Schafer, Denis Wirtz, Dong-Hwee Kim
In the original version of this Article, the affiliation details for Arghavan Louhghalam were incorrectly given as 'Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD, 21218, USA', and it should have been given as 'Department of Civil and Environmental Engineering, University of Massachusetts Dartmouth, Dartmouth, MA 02747, USA'. Furthermore, an incorrect grant number, R1610512, was acknowledged. The correct grant number is NRF-2016R1C1B2015018. These errors have now been corrected in both the PDF and HTML versions of the Article...
March 13, 2018: Nature Communications
Yesi Shi, Xin Pang, Junqing Wang, Gang Liu
TRAIL is a member of the tumor necrosis factor superfamily that can largely trigger apoptosis in a wide variety of cancer cells, but not in normal cells. However, insufficient exposure to cancer tissues or cells and drug resistance has severely impeded the clinical application of TRAIL. Recently, nanobiotechnology has brought about a revolution in advanced drug delivery for enhanced anticancer therapy using TRAIL. With the help of materials science, immunology, genetic engineering, and protein engineering, substantial progress is made by expressing fusion proteins with TRAIL, engineering TRAIL on biological membranes, and loading TRAIL into functional nanocarriers or conjugating it onto their surfaces...
March 12, 2018: Advanced Healthcare Materials
Lu Wang, Yanan Wu, Jia Xie, Sheng Wu, Zhenqiang Wu
The green synthesis of nanoparticles has become increasingly promising due to their potential applications in nanomedicine and materials science. In this study, silver nanoparticles (P-AgNPs) were synthesized from aqueous extracts of P. guajava L. leaf. The synthesized silver nanoparticles were confirmed by UV-vis spectrophotometry at 438 nm. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and zetasizer analyses showed that the average sizes of the P-AgNPs were 20-35 nm, 25 nm, and 25-35 nm, respectively...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Shahira H El-Moslamy
In this report, the local nano-MgO synthesizer strain has been isolated from Ocimum sanctum plant and deposited in GenBank as endophytic Streptomyces coelicolor strain E72. Its intracellular metabolic fraction that contains 7.2 μg/μl of carbohydrate, 6.3 g/l of protein and 5.2 nmol/hr/ml of nitrate reductase used to produce multi-surface shaped nano-MgO with diameter ~25 nm. To the best of our knowledge, this is the first report using statistical nanobiotechnological strategies (Plackett -Burman, Box-Behnken and Taguchi experimental designs) to study and evaluate the endophytic S...
February 28, 2018: Scientific Reports
Sahadevan Neethu, Sebastian Jose Midhun, M A Sunil, Soman Soumya, E K Radhakrishnan, Mathew Jyothis
The green synthesis of silver nanoparticles (AgNPs) using biological systems such as fungi has evolved to become an important area of nanobiotechnology. Herein, we report for the first time the light-induced extracellular synthesis of silver nanoparticles using algicolous endophytic fungus Penicillium polonicum ARA 10, isolated from the marine green alga Chetomorpha antennina. Parametric optimization, including the concentration of AgNO3 , fungal biomass, ratio of cell filtrate and AgNO3 , pH, reaction time and presence of light, was done for rapid AgNPs production...
March 2018: Journal of Photochemistry and Photobiology. B, Biology
Wang Chengzheng, Wen Jiazhi, Chen Shuangjiang, Mallappa Kumara Swamy, Uma Rani Sinniah, Mohd Sayeed Akhtar, Ahmad Umar
Nanobiotechnology has emerged as a promising technology to develop new therapeutically active nanomaterials. The present study was aimed to biosynthesize AgNPs extracellularly using Aspergillus niger JX556221 fungal extract and to evaluate their anticancer potential against colon cancer cell line, HT-29. UV-visible spectral characterization of the synthesized AgNPs showed higher absorption peak at 440 nm wavelength. Transmission Electron Microscopy (TEM) analysis revealed the monodispersed nature of synthesized AgNPs occurring in spherical shape with a size in the range of 20-25 nm...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Behzad Mehrafrooz, Maysam Z Pedram, Ebrahim Ghafar-Zadeh
One of the crucial issues in the pharmacological field is developing new drug delivery systems. The main concern is to develop new methods for improving the drug delivery efficiencies such as low disruptions, precise control of the target of delivery and drug sustainability. Nowadays, there are many various methods for drug delivery systems. Carbon-based nanocarriers are a new efficient tool for translocating drug into the defined area or cells inside the body. These nanocarriers can be functionalized with proteins, peptides and used to transport their freight to cells or defined areas...
January 29, 2018: Sensors
Sylwia Michlewska, Maksim Ionov, Marta Maroto-Díaz, Aleksandra Szwed, Aliaksei Ihnatsyeu-Kachan, Svetlana Loznikova, Dzmitry Shcharbin, Marek Maly, Rafael Gomez Ramirez, Francisco Javier de la Mata, Maria Bryszewska
Dendrimers, which are considered as one of the most promising tools in the field of nanobiotechnology due to their structural organization, showed a great potential in gene therapy, drug delivery, medical imaging and as antimicrobial and antiviral agents. This article is devoted to study interactions between new carbosilane-based metallodendrimers containing ruthenium and anti-cancer small interfering RNA (siRNA). Formation of complexes between anti-cancer siRNAs and Ru-based carbosilane dendrimers was evaluated by transmission electron microscopy, circular dichroism and fluorescence...
April 2018: Journal of Inorganic Biochemistry
Finn Purcell-Milton, Robert McKenna, Lorcan J Brennan, Conor P Cullen, Lilian Guillemeney, Nikita V Tepliakov, Anvar S Baimuratov, Ivan D Rukhlenko, Tatiana S Perova, Georg S Duesberg, Alexander V Baranov, Anatoly V Fedorov, Yurii K Gun'ko
Two-dimensional (2D) nanomaterials have been intensively investigated due to their interesting properties and range of potential applications. Although most research has focused on graphene, atomic layered transition metal dichalcogenides (TMDs) and particularly MoS2 have gathered much deserved attention recently. Here, we report the induction of chirality into 2D chiral nanomaterials by carrying out liquid exfoliation of MoS2 in the presence of chiral ligands (cysteine and penicillamine) in water. This processing resulted in exfoliated chiral 2D MoS2 nanosheets showing strong circular dichroism signals, which were far past the onset of the original chiral ligand signals...
February 27, 2018: ACS Nano
Elham Arkan, Abbas Hemati Azandaryani, Pouran Moradipour, Leila Behbood
BACKGROUND: Biopolymers based materials (polysaccharides, lipids, proteins, and nucleic acids) are one of the basic resources in bio-engineering sciences because of desirable features. Moreover, nanobiotechnology innovates nanomaterial and associated technique in nano medicine (drug delivery and tissue engineering). METHODS: In the nano-medicine, fibers are introduced as a successful biomimetic extracellular matrix scaffolds and drug carrier systems. Electrospinning as a simple and cost-effective technique is used to design nanofibers...
2017: Current Pharmaceutical Biotechnology
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