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https://www.readbyqxmd.com/read/27915977/a-review-on-recent-patents-and-applications-of-inorganic-material-binding-peptides
#1
Veeranjaneyulu Thota, Carole C Perry
Over the past decade, significant progress has been made in the identification of novel material binding peptides having affinity to a wide range of target materials and their use in nanobiotechnological innovations. These material binding peptides (MBPs), also known as solid/ substance binding peptides (SBPs) can be isolated using combinatorial display technologies such as phage display (PD), surface display (cell, bacterial, yeast, mRNA) exhibit material specific selectivity and affinity towards a range of inorganic and organic nanomaterial surfaces including metals, metal oxides, minerals, semiconductors and biomolecules...
December 1, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27906513/smartphone-based-portable-wireless-optical-system-for-the-detection-of-target-analytes
#2
Shreedhar Gautam, Bhagwan S Batule, Hyo Yong Kim, Ki Soo Park, Hyun Gyu Park
Rapid and accurate on-site wireless measurement of hazardous molecules or biomarkers is one of the biggest challenges in nanobiotechnology. We herein describe a novel smartphone-based Portable and Wireless Optical System (PAWS) for rapid, quantitative, and on-site analysis of target analytes. As a proof-of-concept, we employed gold nanoparticles (GNP) and an enzyme, horse radish peroxidase (HRP), to generate colorimetric signals in response to two model target molecules, melamine and hydrogen peroxide, respectively...
December 1, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27901298/biomimicry-promotes-the-efficiency-of-a-10-step-sequential-enzymatic-reaction-on-nanoparticles-converting-glucose-to-lactate
#3
Chinatsu Mukai, Lizeng Gao, Jacquelyn L Nelson, James P Lata, Roy Cohen, Lauren Wu, Meleana M Hinchman, Magnus Bergkvist, Robert W Sherwood, Sheng Zhang, Alexander J Travis
For nanobiotechnology to achieve its potential, complex organic-inorganic systems must grow to utilize the sequential functions of multiple biological components. Critical challenges exist: immobilizing enzymes can block substrate-binding sites or prohibit conformational changes, substrate composition can interfere with activity, and multistep reactions risk diffusion of intermediates. As a result, the most complex tethered reaction reported involves only 3 enzymes. Inspired by the oriented immobilization of glycolytic enzymes on the fibrous sheath of mammalian sperm, here we show a complex reaction of 10 enzymes tethered to nanoparticles...
November 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27881055/patents-in-nanobiotechnology-a-cross-jurisdictional-approach
#4
Padmavati Manchikanti, Shailaja Gnaneshwar, B Ramesh Kumar
BACKGROUND: Bio nanomaterials create new opportunities for advancing medical sciences and diseases treatment in relation to human health care. Innovations in the use of such nanomaterials and nanodevices can lead to significant improvements in the use of drugs/devices. OBJECTIVE: The present study attempts to analyse patenting trends in different areas and compare the patentability criteria and the disclosure norms for nanobiotechnology inventions in countries such as US, EU and India in the field of diagnostics and therapeutics...
November 22, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27797224/glutaraldehyde-mediated-synthesis-of-asparaginase-bound-maghemite-nanocomposites-cytotoxicity-against-human-colon-adenocarcinoma-cells
#5
G Baskar, Garrick Bikku George
Drugs processed using nanobiotechnology may be more biocompatible, with sustainable and stabilised release or action. L-asparaginase produced from fungi has many advantages for treatment of lymphocytic leukemia with lesser side effect. In the present work, maghemite nanobiocomposites of fungal asparaginase were produced using glutaraldehyde-pretreated colloidal magnetic nanoparticles. Formation of nanobiocomposites was observed using laser light scattering and confirmed by UV-visible spectrophotometry with the absorption peak at 497 nm...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27796511/neuromolecular-imaging-a-nanobiotechnology-for-parkinson-s-disease-advancing-pharmacotherapy-for-personalized-medicine
#6
P A Broderick, L Wenning, Y-S Li
Evaluating each patient and animal as its own control achieves personalized medicine, which honors the hippocratic philosophy, explaining that "it is far more important to know what person has the disease than what disease the person has." Similarly, individualizing molecular signaling directly from the patient's brain in real time is essential for providing prompt, patient-based treatment as dictated by the point of care. Fortunately, nanotechnology effectively treats many neurodegenerative diseases. In particular, the new medicinal frontier for the discovery of therapy for Parkinson's disease is nanotechnology and nanobiotechnology...
October 28, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27748519/specific-growth-rate-and-multiplicity-of-infection-affect-high-cell-density-fermentation-with-bacteriophage-m13-for-ssdna-production
#7
Benjamin Kick, Samantha Hensler, Florian Praetorius, Hendrik Dietz, Dirk Weuster-Botz
The bacteriophage M13 has found frequent applications in nanobiotechnology due to its chemically and genetically tunable protein surface and its ability to self-assemble into colloidal membranes. Additionally, its single-stranded (ss) genome is commonly used as scaffold for DNA origami. Despite the manifold uses of M13, upstream production methods for phage and scaffold ssDNA are underexamined with respect to future industrial usage. Here, the high-cell-density phage production with Escherichia coli as host organism was studied in respect of medium composition, infection time, multiplicity of infection and specific growth rate...
October 17, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27747859/curcumin-as-potential-therapeutic-natural-product-a-nanobiotechnological-perspective
#8
REVIEW
Soumitra Shome, Anupam Das Talukdar, Manabendra Dutta Choudhury, Mrinal Kanti Bhattacharya, Hrishikesh Upadhyaya
OBJECTIVES: Nanotechnology-based drug delivery systems can resolve the poor bioavailability issue allied with curcumin. The therapeutic potential of curcumin can be enhanced by making nanocomposite preparation of curcumin with metal oxide nanoparticles, poly lactic-co-glycolic acid (PLGA) nanoparticles and solid lipid nanoparticles that increases its bioavailability in the tissue. KEY FINDINGS: Curcumin has manifold therapeutic effects which include antidiabetic, antihypertensive, anticancer, anti-inflammatory and antimicrobial properties...
December 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27696775/laccase-a-multi-purpose-biocatalyst-at-the-forefront-of-biotechnology
#9
Diana M Mate, Miguel Alcalde
Laccases are multicopper containing enzymes capable of performing one electron oxidation of a broad range of substrates. Using molecular oxygen as the final electron acceptor, they release only water as a by-product, and as such, laccases are eco-friendly, versatile biocatalysts that have generated an enormous biotechnological interest. Indeed, this group of enzymes has been used in different industrial fields for very diverse purposes, from food additive and beverage processing to biomedical diagnosis, and as cross-linking agents for furniture construction or in the production of biofuels...
October 3, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27677514/design-of-self-assembling-protein-polymer-conjugates
#10
Nathan A Carter, Xi Geng, Tijana Z Grove
Protein-polymer conjugates are of particular interest for nanobiotechnology applications because of the various and complementary roles that each component may play in composite hybrid-materials. This chapter focuses on the design principles and applications of self-assembling protein-polymer conjugate materials. We address the general design methodology, from both synthetic and genetic perspective, conjugation strategies, protein vs. polymer driven self-assembly and finally, emerging applications for conjugate materials...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27648483/an-enteric-micromotor-can-selectively-position-and-spontaneously-propel-in-the-gastrointestinal-tract
#11
Jinxing Li, Soracha Thamphiwatana, Wenjuan Liu, Berta Esteban-Fernández de Ávila, Pavimol Angsantikul, Elodie Sandraz, Jianxing Wang, Tailin Xu, Fernando Soto, Valentin Ramez, Xiaolei Wang, Weiwei Gao, Liangfang Zhang, Joseph Wang
The gastrointestinal (GI) tract, which hosts hundreds of bacteria species, becomes the most exciting organ for the emerging microbiome research. Some of these GI microbes are hostile and cause a variety of diseases. These bacteria colonize in different segments of the GI tract dependent on the local physicochemical and biological factors. Therefore, selectively locating therapeutic or imaging agents to specific GI segments is of significant importance for studying gut microbiome and treating various GI-related diseases...
September 20, 2016: ACS Nano
https://www.readbyqxmd.com/read/27633935/gold-nanocrystals-with-dna-directed-morphologies
#12
Xingyi Ma, June Huh, Wounjhang Park, Luke P Lee, Young Jik Kwon, Sang Jun Sim
Precise control over the structure of metal nanomaterials is important for developing advanced nanobiotechnology. Assembly methods of nanoparticles into structured blocks have been widely demonstrated recently. However, synthesis of nanocrystals with controlled, three-dimensional structures remains challenging. Here we show a directed crystallization of gold by a single DNA molecular regulator in a sequence-independent manner and its applications in three-dimensional topological controls of crystalline nanostructures...
September 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27614818/multifunctional-gold-based-nanocomposites-for-theranostics
#13
REVIEW
Lev A Dykman, Nikolai G Khlebtsov
Although Au-particle potential in nanobiotechnology has been recognized for the last 15 years, new insights into the unique properties of multifunctional nanostructures have just recently started to emerge. Multifunctional gold-based nanocomposites combine multiple modalities to improve the efficacy of the therapeutic and diagnostic treatment of cancer and other socially significant diseases. This review is focused on multifunctional gold-based theranostic nanocomposites, which can be fabricated by three main routes...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27600262/heal-fuel-and-feed-the-world-advances-in-nanobiotechnology
#14
EDITORIAL
Guang-Hui Ma, Dan Wang
No abstract text is available yet for this article.
September 2016: Small
https://www.readbyqxmd.com/read/27554277/ultrasonic-assisted-green-synthesis-of-flower-like-silver-nanocolloids-using-marine-sponge-extract-and-its-effect-on-oral-biofilm-bacteria-and-oral-cancer-cell-lines
#15
D Inbakandan, C Kumar, M Bavanilatha, Dune Naga Ravindra, R Kirubagaran, S Ajmal Khan
The knowhow followed for synthesis, characterization and application of nanomaterials has become an important branch of nanoscience. The use of marine sponges for the synthesis of metal nanoparticles is still in the budding level of current nanobiotechnology. This paper reports a single step one pot biosynthesis utilizing marine sponge (Haliclona exigua) extract as a reducing agent by means of a conventional ultrasonic bath on the formation and growth of flower like silver nanocolloids. These silver nanocolloids were characterized through UV visible spectroscopy, High Resolution Transmission Electron Microscope, Fourier Transform Infrared spectroscopy and X-ray Diffractometer...
October 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27550384/site-specific-control-of-multiple-mineralizations-using-a-designed-peptide-and-dna
#16
Kenji Usui, Makoto Ozaki, Aoi Yamada, Yoshio Hamada, Takaaki Tsuruoka, Takahito Imai, Kin-Ya Tomizaki
We have developed a site-specific method for precipitating multiple inorganic compounds using target DNA and a designed peptide consisting of a peptide nucleic acid (PNA) sequence and an inorganic compound-precipitating sequence. This system for controlled site-specific precipitation represents a powerful tool for use in nanobiotechnology and materials science.
October 21, 2016: Nanoscale
https://www.readbyqxmd.com/read/27550218/biological-synthesis-of-nanosized-sulfide-semiconductors-current-status-and-future-prospects
#17
REVIEW
João Pinto da Costa, Ana Violeta Girão, Tito Trindade, Maria Clara Costa, Armando Duarte, Teresa Rocha-Santos
There have been extensive and comprehensive reviews in the field of metal sulfide precipitation in the context of environmental remediation. However, these works have focused mainly on the removal of metals from aqueous solutions-usually, metal-contaminated effluents-with less emphasis on the precipitation process and on the end-products, frequently centering on metal removal efficiencies. Recently, there has been an increasing interest not only in the possible beneficial effects of these bioremediation strategies for metal-rich effluents but also on the formed precipitates...
October 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27499623/nanobody-derived-nanobiotechnology-tool-kits-for-diverse-biomedical-and-biotechnology-applications
#18
REVIEW
Yongzhong Wang, Zhen Fan, Lei Shao, Xiaowei Kong, Xianjuan Hou, Dongrui Tian, Ying Sun, Yazhong Xiao, Li Yu
Owing to peculiar properties of nanobody, including nanoscale size, robust structure, stable and soluble behaviors in aqueous solution, reversible refolding, high affinity and specificity for only one cognate target, superior cryptic cleft accessibility, and deep tissue penetration, as well as a sustainable source, it has been an ideal research tool for the development of sophisticated nanobiotechnologies. Currently, the nanobody has been evolved into versatile research and application tool kits for diverse biomedical and biotechnology applications...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27499268/toward-chemical-perfection-of-graphene-based-gene-carrier-via-ugi-multicomponent-assembly-process
#19
Aram Rezaei, Omid Akhavan, Ehsan Hashemi, Mehdi Shamsara
The graphene-based materials with unique, versatile, and tunable properties have brought new opportunities for the leading edge of advanced nanobiotechnology. In this regard, the use of graphene in gene delivery applications is still at early stages. In this study, we successfully designed a new complex of carboxylated-graphene (G-COOH) with ethidium bromide (EtBr) and used it as a nanovector for efficient gene delivery into the AGS cells. G-COOH, with carboxyl functions on its surface, in the presence of EtBr, formaldehyde, and cyclohexylisocyanide were participated in Ugi four component reaction to fabricate a stable amphiphilic graphene-EtBr (AG-EtBr) composite...
September 12, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27468125/diffusion-of-fluorescently-labeled-bacteriocin-from-edible-nanomaterials-and-embedded-nano-bioactive-coatings
#20
Muhammad Imran, Anne-Marie Revol-Junelles, Grégory Francius, Stéphane Desobry
Application of nano-biotechnology to improve the controlled release of drugs or functional agents is widely anticipated to transform the biomedical, pharmaceutical, and food safety trends. The purpose of the current study was to assess and compare the release rates of fluorescently labeled antimicrobial peptide nisin (lantibiotic/biopreservative) from liposomal nanocarriers. The elevated temperature, high electrostatic attraction between anionic bilayers and cationic nisin, larger size, and higher encapsulation efficiency resulted in rapid and elevated release through pore formation...
August 24, 2016: ACS Applied Materials & Interfaces
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