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Nanobiotechnology

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https://www.readbyqxmd.com/read/28421881/factors-pivotal-for-designing-of-nanoantimicrobials-an-exposition
#1
Bushra Jamil, Muhammad Imran
Understanding the interplay between bacterial pathogens and antimicrobials is a key to realize the control over infections causing morbidity and mortality. An important current issue of contemporary medicine and microbiology is the search for new strategies for adequate therapy of infectious diseases associated with rapidly emerging multidrug-resistant (MDR) pathogens. Recently, a great deal of progress has been made in the field of nanobiotechnology towards the development of various nanoantimicrobials (NAMs) as novel therapeutic solution...
April 19, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28414202/recent-advances-in-peptide-nucleic-acid-for-cancer-bionanotechnology
#2
REVIEW
Jun-Chen Wu, Qing-Chun Meng, Hong-Mei Ren, Hong-Tao Wang, Jie Wu, Qi Wang
Peptide nucleic acid (PNA) is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to hybridize with neutral nucleic acids and their special chemical and biological properties. In recent years, PNAs have emerged in nanobiotechnology for cancer diagnosis and therapy due to their high affinity and sequence selectivity toward corresponding DNA and RNA...
April 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28398005/nanotherapy-for-duchenne-muscular-dystrophy
#3
REVIEW
Michael E Nance, Chady H Hakim, N Nora Yang, Dongsheng Duan
Duchenne muscular dystrophy (DMD) is a lethal X-linked childhood muscle wasting disease caused by mutations in the dystrophin gene. Nanobiotechnology-based therapies (such as synthetic nanoparticles and naturally existing viral and nonviral nanoparticles) hold great promise to replace and repair the mutated dystrophin gene and significantly change the disease course. While a majority of DMD nanotherapies are still in early preclinical development, several [such as adeno-associated virus (AAV)-mediated systemic micro-dystrophin gene therapy] are advancing for phase I clinical trials...
April 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28367155/biotechnological-advancements-and-begomovirus-management-in-okra-abelmoschus-esculentus-l-status-and-perspectives
#4
REVIEW
Gyan P Mishra, Bijendra Singh, Tania Seth, Achuit K Singh, Jaydeep Halder, Nagendran Krishnan, Shailesh K Tiwari, Prabhakar M Singh
Despite the importance of okra, as one of the important vegetable crop, very little attention has been paid to its genetic improvement using advanced biotechnological tools. The exploitation of marker assisted breeding in okra is often limited due to the availability of a few molecular markers, the absence of molecular genetic-map(s), and other molecular tools. Chromosome linkage-groups were not yet constructed for this crop and reports on marker development are very scanty and mostly hovering around cultivar characterization...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28361239/implications-of-molecular-diversity-of-chitin-and-its-derivatives
#5
REVIEW
Faez Iqbal Khan, Safikur Rahman, Aarfa Queen, Shahzaib Ahamad, Sher Ali, Jihoe Kim, Md Imtaiyaz Hassan
Chitin is a long unbranched polysaccharide, made up of β-1,4-linked N-acetylglucosamine which forms crystalline fiber-like structure. It is present in the fungal cell walls, insect and crustacean cuticles, nematode eggshells, and protozoa cyst. We provide a critical appraisal on the chemical modifications of chitin and its derivatives in the context of their improved efficacy in medical applications without any side effect. Recent advancement in nanobiotechnology has helped to synthesize several chitin derivatives having significant biological applications...
March 31, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28326065/antifungal-therapy-for-systemic-mycosis-and-the-nanobiotechnology-era-improving-efficacy-biodistribution-and-toxicity
#6
REVIEW
Ana C O Souza, Andre C Amaral
Fungal diseases have been emerging as an important public health problem worldwide with the increase in host predisposition factors due to immunological dysregulations, immunosuppressive and/or anticancer therapy. Antifungal therapy for systemic mycosis is limited, most of times expensive and causes important toxic effects. Nanotechnology has become an interesting strategy to improve efficacy of traditional antifungal drugs, which allows lower toxicity, better biodistribution, and drug targeting, with promising results in vitro and in vivo...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28260887/cerium-oxide-nanoparticles-green-synthesis-and-biological-applications
#7
REVIEW
Fahimeh Charbgoo, Mansor Bin Ahmad, Majid Darroudi
CeO2 nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO2-NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO2-NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO2-NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28188158/nanoscale-hybrid-systems-based-on-carbon-nanotubes-for-biological-sensing-and-control
#8
Youngtak Cho, Narae Shin, Daesan Kim, Jae Yeol Park, Seunghun Hong
This paper provides a concise review on the recent development of nanoscale hybrid systems based on carbon nanotubes (CNTs) for biological sensing and control. CNT-based hybrid systems have been intensively studied for versatile applications of biological interfaces such as sensing, cell therapy, and tissue regeneration. Recent advances in nanobiotechnology not only enable the fabrication of highly-sensitive biosensors at nanoscale but also allow the applications in the controls of cell growth and differentiation...
February 10, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28176876/engineering-a-ph-responsive-pore-forming-protein
#9
Matic Kisovec, Saša Rezelj, Primož Knap, Miša Mojca Cajnko, Simon Caserman, Ajda Flašker, Nada Žnidaršič, Matej Repič, Janez Mavri, Yi Ruan, Simon Scheuring, Marjetka Podobnik, Gregor Anderluh
Listeriolysin O (LLO) is a cytolysin capable of forming pores in cholesterol-rich lipid membranes of host cells. It is conveniently suited for engineering a pH-governed responsiveness, due to a pH sensor identified in its structure that was shown before to affect its stability. Here we introduced a new level of control of its hemolytic activity by making a variant with hemolytic activity that was pH-dependent. Based on detailed structural analysis coupled with molecular dynamics and mutational analysis, we found that the bulky side chain of Tyr406 allosterically affects the pH sensor...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28160725/design-and-construction-of-self-assembling-supramolecular-protein-complexes-using-artificial-and-fusion-proteins-as-nanoscale-building-blocks
#10
REVIEW
Naoya Kobayashi, Ryoichi Arai
The central goal of nanobiotechnology is to design and construct novel biomaterials of nanometer sizes. In this short review, we describe recent progress of several approaches for designing and creating artificial self-assembling protein complexes and primarily focus on the following biotechnological strategies for using artificial and fusion proteins as nanoscale building blocks: fusion proteins designed for symmetrical self-assembly; three-dimensional domain-swapped oligomers; self-assembling designed coiled-coil peptide modules; metal-directed self-assembling engineered proteins; computationally designed self-assembling de novo proteins; and self-assembling protein nanobuilding blocks (PN-Blocks) using an intermolecularly folded dimeric de novo protein...
February 1, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28145686/in-situ-characterization-of-protein-adsorption-onto-nanoparticles-by-fluorescence-correlation-spectroscopy
#11
Li Shang, G Ulrich Nienhaus
Nanotechnology holds great promise for applications in many fields including biology and medicine. Unfortunately, the processes occurring at the interface between nanomaterials and living systems are exceedingly complex and not yet well understood, which has significantly hampered the realization of many nanobiotechnology applications. Whenever nanoparticles (NPs) are incorporated by a living organism, a protein adsorption layer, also known as the "protein corona", forms on the NP surface. Accordingly, living organisms interact with protein-coated rather than bare NPs, and their biological responses depend on the nature of the protein corona...
February 1, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28130158/smart-materials-on-the-way-to-theranostic-nanorobots-molecular-machines-and-nanomotors-advanced-biosensors-and-intelligent-vehicles-for-drug-delivery
#12
Ilya L Sokolov, Vladimir R Cherkasov, Andrey A Tregubov, Sveatoslav R Buiucli, Maxim P Nikitin
BACKGROUND: Theranostics, a fusion of two key parts of modern medicine - diagnostics and therapy of the organism's disorders, promises to bring the efficacy of medical treatment to a fundamentally new level and to become the basis of personalized medicine. Extrapolating today's progress in the field of smart materials to the long-run prospect, we can imagine future intelligent agents capable of performing complex analysis of different physiological factors inside the living organism and implementing a built-in program thereby triggering a series of therapeutic actions...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28078770/synthetic-plant-virology-for-nanobiotechnology-and-nanomedicine
#13
REVIEW
John F C Steele, Hadrien Peyret, Keith Saunders, Roger Castells-Graells, Johanna Marsian, Yulia Meshcheriakova, George P Lomonossoff
Nanotechnology is a rapidly expanding field seeking to utilize nano-scale structures for a wide range of applications. Biologically derived nanostructures, such as viruses and virus-like particles (VLPs), provide excellent platforms for functionalization due to their physical and chemical properties. Plant viruses, and VLPs derived from them, have been used extensively in biotechnology. They have been characterized in detail over several decades and have desirable properties including high yields, robustness, and ease of purification...
January 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28067307/fluorescent-gold-nanoclusters-for-selective-detection-of-dopamine-in-cerebrospinal-fluid
#14
Saravanan Govindaraju, Seshadri Reddy Ankireddy, Buddolla Viswanath, Jongsung Kim, Kyusik Yun
Since the last two decades, protein conjugated fluorescent gold nanoclusters (NCs) owe much attention in the field of medical and nanobiotechnology due to their excellent photo stability characteristics. In this paper, we reported stable, nontoxic and red fluorescent emission BSA-Au NCs for selective detection of L-dopamine (DA) in cerebrospinal fluid (CSF). The evolution was probed by various instrumental techniques such as UV-vis spectroscopy, High resolution transmission electron microscopy (HTEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL)...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045501/advancement-of-the-emerging-field-of-rna-nanotechnology
#15
Daniel Jasinski, Farzin Haque, Daniel W Binzel, Peixuan Guo
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of programmable RNA nanoparticles with defined shape, size, and stoichiometry have been developed for diverse applications in nanobiotechnology. The rising popularity of RNA nanoparticles is due to a number of factors: (1) removing the concern of RNA degradation in vitro and in vivo by introducing chemical modification into nucleotides without significant alteration of the RNA property in folding and self-assembly; (2) confirming the concept that RNA displays very high thermodynamic stability and is suitable for in vivo trafficking and other applications; (3) obtaining the knowledge to tune the immunogenic properties of synthetic RNA constructs for in vivo applications; (4) increased understanding of the 4D structure and intermolecular interaction of RNA molecules; (5) developing methods to control shape, size, and stoichiometry of RNA nanoparticles; (6) increasing knowledge of regulation and processing functions of RNA in cells; (7) decreasing cost of RNA production by biological and chemical synthesis; and (8) proving the concept that RNA is a safe and specific therapeutic modality for cancer and other diseases with little or no accumulation in vital organs...
February 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28004640/designing-synthetic-rna-for-delivery-by-nanoparticles
#16
Dominika Jedrzejczyk, Edyta Gendaszewska-Darmach, Roza Pawlowska, Arkadiusz Chworos
The rapid development of synthetic biology and nanobiotechnology has led to the construction of various synthetic RNA nanoparticles of different functionalities and potential applications. As they occur naturally, nucleic acids are an attractive construction material for biocompatible nanoscaffold and nanomachine design. In this review, we provide an overview of the types of RNA and nucleic acid's nanoparticle design, with the focus on relevant nanostructures utilized for gene-expression regulation in cellular models...
March 29, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27915977/a-review-on-recent-patents-and-applications-of-inorganic-material-binding-peptides
#17
Veeranjaneyulu Thota, Carole C Perry
Over the past decade, significant progress has been made in the identification of novel material binding peptides having affinity to a wide range of target materials and their use in nanobiotechnological innovations. These material binding peptides (MBPs), also known as solid/ substance binding peptides (SBPs) can be isolated using combinatorial display technologies such as phage display (PD), surface display (cell, bacterial, yeast, mRNA) exhibit material specific selectivity and affinity towards a range of inorganic and organic nanomaterial surfaces including metals, metal oxides, minerals, semiconductors and biomolecules...
December 1, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27906513/smartphone-based-portable-wireless-optical-system-for-the-detection-of-target-analytes
#18
Shreedhar Gautam, Bhagwan S Batule, Hyo Yong Kim, Ki Soo Park, Hyun Gyu Park
Rapid and accurate on-site wireless measurement of hazardous molecules or biomarkers is one of the biggest challenges in nanobiotechnology. A novel smartphone-based Portable and Wireless Optical System (PAWS) for rapid, quantitative, and on-site analysis of target analytes is described. As a proof-of-concept, we employed gold nanoparticles (GNP) and an enzyme, horse radish peroxidase (HRP), to generate colorimetric signals in response to two model target molecules, melamine and hydrogen peroxide, respectively...
February 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/27901298/biomimicry-promotes-the-efficiency-of-a-10-step-sequential-enzymatic-reaction-on-nanoparticles-converting-glucose-to-lactate
#19
Chinatsu Mukai, Lizeng Gao, Jacquelyn L Nelson, James P Lata, Roy Cohen, Lauren Wu, Meleana M Hinchman, Magnus Bergkvist, Robert W Sherwood, Sheng Zhang, Alexander J Travis
For nanobiotechnology to achieve its potential, complex organic-inorganic systems must grow to utilize the sequential functions of multiple biological components. Critical challenges exist: immobilizing enzymes can block substrate-binding sites or prohibit conformational changes, substrate composition can interfere with activity, and multistep reactions risk diffusion of intermediates. As a result, the most complex tethered reaction reported involves only 3 enzymes. Inspired by the oriented immobilization of glycolytic enzymes on the fibrous sheath of mammalian sperm, here we show a complex reaction of 10 enzymes tethered to nanoparticles...
January 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/27881055/patents-in-nanobiotechnology-a-cross-jurisdictional-approach
#20
REVIEW
Padmavati Manchikanti, Shailaja Uppala, Ramesh Kumar Bonta
BACKGROUND: Bionanomaterials create new opportunities for advancing medical sciences and diseases treatment in relation to human health care. Innovations in the use of such nanomaterials and nanodevices can lead to significant improvements in the use of drugs/devices. OBJECTIVE: The present study attempts to analyse patenting trends in different areas and compare the patentability criteria and the disclosure norms for nanobiotechnology inventions in countries such as US, EU and India in the field of diagnostics and therapeutics...
2017: Recent Patents on Biotechnology
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