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Nanobiotechnology

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https://www.readbyqxmd.com/read/28715309/rise-of-the-nanorobots-advances-in-control-molecular-detection-and-nanoscale-actuation-are-bringing-us-closer-to-a-new-era-of-technology-enhanced-by-nanorobots
#1
Stanislav Tsitkov, Henry Hess
In 1988, a Scientific American article by A.K. Dewdney [1] on the work of nanotechnologist K. Eric Drexler spurred public interest in the nascent field of nanotechnology and its potential for advancing humanity into a new technological age. The article portrayed a world run by nanoscale machines that could operate in any environment (Figure 1), with uses ranging from fighting infections in the human body to building tomorrow's skyscrapers. Nearly 30 years later, these visions of the future are closer than ever...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28715014/amyloid-scaffolds-as-alternative-chlorosomes
#2
REVIEW
Rolando F Rengifo, Noel X Li, Anthony Sementilli, David G Lynn
Living systems contain remarkable functional capability built within sophisticated self-organizing frameworks. Defining the assembly codes that coordinate these systems could greatly extend nanobiotechnology. To that end, we have highlighted the self-assembling architecture of the chlorosome antenna arrays and report the emulation and extension of their features for the development of cell-compatible photoredox materials. We specifically review work on amyloid peptide scaffolds able to (1) organize light-harvesting chromophores, (2) break peptide bilayer symmetry for directional energy and electron transfer, and (3) incorporate redox active metal ions at high density for energy storage...
July 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28661337/living-on-the-edge-re-shaping-the-interface-of-synthetic-biology-and-nanotechnology
#3
Shang-Jung Wu, Ardemis A Boghossian
A new team of researchers at EPFL is taking an 'anti-disciplinary' approach to creating optical devices. These devices take advantage of the synergy in tuning both nano- and bio-material properties, coupling the advantages of two growing, albeit traditionally distinct, fields. With applications spanning from biosensing and microarray assays to living photovoltaics, the Laboratory of NanoBiotechnology (LNB) is uncovering an unexplored space for the next generation of chemical analytics and light-harvesting technologies...
November 30, 2016: Chimia
https://www.readbyqxmd.com/read/28650154/interrogating-detergent-desolvation-of-nanopore-forming-proteins-by-fluorescence-polarization-spectroscopy
#4
Aaron J Wolfe, Yi-Ching Hsueh, Adam R Blanden, Mohammad M Mohammad, Bach Pham, Avinash K Thakur, Stewart N Loh, Min Chen, Liviu Movileanu
Understanding how membrane proteins interact with detergents is of fundamental and practical significance in structural and chemical biology as well as in nanobiotechnology. Current methods for inspecting protein-detergent complex (PDC) interfaces require high concentrations of protein and are of low throughput. Here, we describe a scalable, spectroscopic approach that uses nanomolar protein concentrations in native solutions. This approach, which is based on steady-state fluorescence polarization (FP) spectroscopy, kinetically resolves the dissociation of detergents from membrane proteins and protein unfolding...
July 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28626557/electrostatically-driven-resonance-energy-transfer-in-cationic-biocompatible-indium-phosphide-quantum-dots
#5
Gayathri Devatha, Soumendu Roy, Anish Rao, Abhik Mallick, Sudipta Basu, Pramod P Pillai
Indium Phosphide Quantum Dots (InP QDs) have emerged as an alternative to toxic metal ion based QDs in nanobiotechnology. The ability to generate cationic surface charge, without compromising stability and biocompatibility, is essential in realizing the full potential of InP QDs in biological applications. We have addressed this challenge by developing a place exchange protocol for the preparation of cationic InP/ZnS QDs. The quaternary ammonium group provides the much required permanent positive charge and stability to InP/ZnS QDs in biofluids...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28625680/plant-made-potyvirus-like-particles-used-for-log-increasing-antibody-sensing-capacity
#6
Ivonne González-Gamboa, Pilar Manrique, Flora Sánchez, Fernando Ponz
Deployment of the elongated flexuous virions of Turnip mosaic virus (TuMV), a potyvirus, for peptide display on their external surface has been previously reported by us. Nonetheless, both in TuMV and other potyviruses some peptides hinder the ability of the virus to infect host plants. We found that a peptide derived from the human thrombin receptor (TR) inhibited TuMV infectivity. In an effort to get around this problem, TuMV virus-like particles (VLPs) were produced in plants by transient high-level expression of wild-type or recombinant coat protein (CP)...
June 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28601037/enterococcus-species-for-the-one-pot-biofabrication-of-gold-nanoparticles-characterization-and-nanobiotechnological-applications
#7
Iyabo Christianah Oladipo, Agbaje Lateef, Joseph Adetunji Elegbede, Musibau Adewuyi Azeez, Tesleem Babatunde Asafa, Taofeek Akangbe Yekeen, Akeem Akinboro, Evariste Bosco Gueguim-Kana, Lorika Selomi Beukes, Tolulope Oluyomi Oluyide, Oluwatoyin Rebecca Atanda
In the current work, cell-free extracts of four strains of non-pathogenic Enterococcus species of food origin, were studied for the green synthesis of gold nanoparticles (AuNPs), and characterized by UV-Vis absorption spectroscopy, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The AuNPs were evaluated for their Anopheles gambiae larvicidal, dye degradation, antioxidant and thrombolytic activities. The blue-black colloidal AuNPs which absorbed maximally at 549-552nm were nearly spherical in shape, and crystalline in nature with size of 8-50nm...
June 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28528952/an-overview-of-natural-renewable-bio-polymer-lignin-towards-nano-and-biotechnological-applications
#8
REVIEW
Selvaraj Mohana Roopan
Lignin were said to be major bio-polymer next to cellulose which is an abundant biopolymer. This type of lignin was mostly isolated from woods which were named after their physical, morphological appearances and majorly on extracting sources. Still now there are very few reports on isolation, identification of pure lignin and isolating pathways are also not well defined. Molecular weight of lignin varies from thousands to ten thousands which are not explored accurately. Even-though lignins were surrounded by these many hurdles it has various application studies which were studied and reported...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28510082/biomedical-applications-of-nanotechnology
#9
REVIEW
Ana P Ramos, Marcos A E Cruz, Camila B Tovani, Pietro Ciancaglini
The ability to investigate substances at the molecular level has boosted the search for materials with outstanding properties for use in medicine. The application of these novel materials has generated the new research field of nanobiotechnology, which plays a central role in disease diagnosis, drug design and delivery, and implants. In this review, we provide an overview of the use of metallic and metal oxide nanoparticles, carbon-nanotubes, liposomes, and nanopatterned flat surfaces for specific biomedical applications...
April 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28478677/nanotoxicity-in-systemic-circulation-and-wound-healing
#10
Mandeep Singh Bakshi
Nanotoxicity of nanomaterials is an important issue in view of their potential applications in systemic circulation and wound healing dressing. This account specifically deals with several characteristic features of different nanomaterials which induce hemolysis and how to make them hemocompatible. The shape, size, and surface functionalities of naked metallic as well as nonmetallic nanoparticles surfaces are responsible for the hemolysis. An appropriate coating of biocompatible molecules dramatically reduces hemolysis and promotes their ability as safe drug delivery vehicles...
May 23, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28471067/functional-magnetic-hybrid-nanomaterials-for-biomedical-diagnosis-and-treatment
#11
REVIEW
Xin Tian, Lechuan Zhang, Mo Yang, Lei Bai, Yiheng Dai, Zhiqiang Yu, Yue Pan
Magnetic nanomaterials integrating supplemental functional materials are called magnetic hybrid nanomaterials (MHNs). Such MHNs have drawn increasing attention due to their biocompatibility and the potential applications either as alternative contrast enhancing agents or effective heat nanomediators in hyperthermia therapy. The joint function comes from the hybrid nanostructures. Hybrid nanostructures of different modification can be easily achieved owing to the large surface-area-to-volume ratio and sophisticated surface characteristic...
May 4, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28470586/advanced-analgesic-drug-delivery-and-nanobiotechnology
#12
REVIEW
Nicoleta Stoicea, Juan Fiorda-Diaz, Nicholas Joseph, Muhammad Shabsigh, Carlos Arias-Morales, Alicia A Gonzalez-Zacarias, Ana Mavarez-Martinez, Stephen Marjoribanks, Sergio D Bergese
Transdermal administration of analgesic medications offers several benefits over alternative routes of administration, including a decreased systemic drug load with fewer side effects, and avoidance of drug degradation by the gastrointestinal tract. Transdermal administration also offers a convenient mode of drug administration over an extended period of time, particularly desirable in pain medicine. A transdermal administration route may also offer increased safety for drugs with a narrow therapeutic window...
July 2017: Drugs
https://www.readbyqxmd.com/read/28458741/thermal-and-aqueous-stability-improvement-of-graphene-oxide-enhanced-diphenylalanine-nanocomposites
#13
Kate Ryan, Sabine M Neumayer, Harsha Vardhan R Maraka, Nicolae-Viorel Buchete, Andrei L Kholkin, James H Rice, Brian J Rodriguez
Nanocomposites of diphenylalanine (FF) and carbon based materials provide an opportunity to overcome drawbacks associated with using FF micro- and nanostructures in nanobiotechnology applications, in particular their poor structural stability in liquid solutions. In this study, FF/graphene oxide (GO) composites were found to self-assemble into layered micro- and nanostructures, which exhibited improved thermal and aqueous stability. Dependent on the FF/GO ratio, the solubility of these structures was reduced to 35...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28454046/preliminary-investigation-of-catalytic-antioxidant-anticancer-and-bactericidal-activity-of-green-synthesized-silver-and-gold-nanoparticles-using-actinidia-deliciosa
#14
Saraschandra Naraginti, Yi Li
Herein we report a rapid low cost one step green synthetic method using Actinidia deliciosa fruit extract for preparation of stable and multifunctional silver and gold nanoparticles. The synthesized nanoparticles were successfully used as green catalysts for the reduction of 4-nitrophenol (4-NP) and methylene blue (MB). The enhanced biological activity of the prepared nanoparticles was investigated based on its highly stable antioxidant, anticancer and bactericidal effects. TEM micrographs showed that the silver nanoparticles (AgNPs) formed were predominantly spherical in shape having diameters ranging from 25 to 40nm, while gold nanoparticles (AuNPs) shown particle size ranges from 7 to 20nm...
May 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28451297/immunological-properties-of-gold-nanoparticles
#15
Lev A Dykman, Nikolai G Khlebtsov
In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28435439/nanobiotechnology-cell-membrane-based-delivery-systems
#16
Pengfei Zhang, Gang Liu, Xiaoyuan Chen
The increasingly rapid pace of research in the field of bioinspired drug delivery systems is revealing the promise of cell membrane-based nanovesicles for biomedical applications. Those cell membrane-based nanoparticles combine the natural functionalities of cell plasma membranes and the bioengineering flexibility of synthetic nanomaterials, and such versatility provides a means of designing exciting new drug formulations for personalized treatment in future nanomedicine.
April 2017: Nano Today
https://www.readbyqxmd.com/read/28434263/plant-protein-based-hydrophobic-fine-and-ultrafine-carrier-particles-in-drug-delivery-systems
#17
Hedieh Malekzad, Hamed Mirshekari, Parham Sahandi Zangabad, S M Moosavi Basri, Fazel Baniasadi, Maryam Sharifi Aghdam, Mahdi Karimi, Michael R Hamblin
For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes...
April 24, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28421881/factors-pivotal-for-designing-of-nanoantimicrobials-an-exposition
#18
Bushra Jamil, Muhammad Imran
Understanding the interplay between bacterial pathogens and antimicrobials is a key to realize the control over infections causing morbidity and mortality. An important current issue of contemporary medicine and microbiology is the search for new strategies for adequate therapy of infectious diseases associated with rapidly emerging multidrug-resistant (MDR) pathogens. Recently, a great deal of progress has been made in the field of nanobiotechnology towards the development of various nanoantimicrobials (NAMs) as novel therapeutic solution...
April 19, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28414202/recent-advances-in-peptide-nucleic-acid-for-cancer-bionanotechnology
#19
REVIEW
Jun-Chen Wu, Qing-Chun Meng, Hong-Mei Ren, Hong-Tao Wang, Jie Wu, Qi Wang
Peptide nucleic acid (PNA) is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to hybridize with neutral nucleic acids and their special chemical and biological properties. In recent years, PNAs have emerged in nanobiotechnology for cancer diagnosis and therapy due to their high affinity and sequence selectivity toward corresponding DNA and RNA...
June 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28398005/nanotherapy-for-duchenne-muscular-dystrophy
#20
REVIEW
Michael E Nance, Chady H Hakim, N Nora Yang, Dongsheng Duan
Duchenne muscular dystrophy (DMD) is a lethal X-linked childhood muscle wasting disease caused by mutations in the dystrophin gene. Nanobiotechnology-based therapies (such as synthetic nanoparticles and naturally existing viral and nonviral nanoparticles) hold great promise to replace and repair the mutated dystrophin gene and significantly change the disease course. While a majority of DMD nanotherapies are still in early preclinical development, several [such as adeno-associated virus (AAV)-mediated systemic micro-dystrophin gene therapy] are advancing for phase I clinical trials...
April 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
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