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https://www.readbyqxmd.com/read/28078770/synthetic-plant-virology-for-nanobiotechnology-and-nanomedicine
#1
REVIEW
John F C Steele, Hadrien Peyret, Keith Saunders, Roger Castells-Graells, Johanna Marsian, Yulia Meshcheriakova, George P Lomonossoff
Nanotechnology is a rapidly expanding field seeking to utilize nano-scale structures for a wide range of applications. Biologically derived nanostructures, such as viruses and virus-like particles (VLPs), provide excellent platforms for functionalization due to their physical and chemical properties. Plant viruses, and VLPs derived from them, have been used extensively in biotechnology. They have been characterized in detail over several decades and have desirable properties including high yields, robustness, and ease of purification...
January 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28067307/fluorescent-gold-nanoclusters-for-selective-detection-of-dopamine-in-cerebrospinal-fluid
#2
Saravanan Govindaraju, Seshadri Reddy Ankireddy, Buddolla Viswanath, Jongsung Kim, Kyusik Yun
Since the last two decades, protein conjugated fluorescent gold nanoclusters (NCs) owe much attention in the field of medical and nanobiotechnology due to their excellent photo stability characteristics. In this paper, we reported stable, nontoxic and red fluorescent emission BSA-Au NCs for selective detection of L-dopamine (DA) in cerebrospinal fluid (CSF). The evolution was probed by various instrumental techniques such as UV-vis spectroscopy, High resolution transmission electron microscopy (HTEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL)...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045501/the-advancement-of-the-emerging-field-of-rna-nanotechnology
#3
Daniel Jasinski, Farzin Haque, Daniel W Binzel, Peixuan Guo
The field of RNA nanotechnology has advanced rapidly during the last decade. A variety of programmable RNA nanoparticles with defined shape, size, and stoichiometry have been developed for diverse applications in nanobiotechnology. The rising popularity of RNA nanoparticles is due to a number of factors: (1) Removing the concern of RNA degradation in vitro and in vivo by introducing chemical modification into nucleotides without significant alteration of the RNA property in folding and self-assembly; (2) Confirming the concept that RNA displays very high thermodynamic stability and is suitable for in vivo trafficking and other applications; (3) Obtaining the knowledge to tune the immunogenic properties of synthetic RNA constructs for in vivo applications; (4) Increased understanding of the 4D structure and intermolecular interaction of RNA molecules; (5) Developing methods to control shape, size and stoichiometry of RNA nanoparticles; (6) Increasing knowledge of unique regulation and processing functions of RNA in cells; (7) Decreasing cost of RNA production by biological and chemical synthesis; and (8) Proving the concept that RNA is a safe and specific therapeutic modality for cancer and other diseases with little or no accumulation in vital organs...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28004640/designing-synthetic-rna-for-delivery-by-nanoparticles
#4
Dominika Jedrzejczyk, Edyta Gendaszewska-Darmach, Roza Pawlowska, Arkadiusz Chworos
The synthetic biology and nanobiotechnology rapid development has led to construction of various synthetic RNA nanoparticles of different functionalities and potential applications. As naturally occurring, the nucleic acids are an attractive construction material for biocompatible nanoscaffolds and nanomachines design. In this review, we provide an overview on the types of RNA, nucleic acid's nanoparticle design with the focus on relevant nanostructures utilized for gene expression regulation in cellular models...
December 22, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27915977/a-review-on-recent-patents-and-applications-of-inorganic-material-binding-peptides
#5
Veeranjaneyulu Thota, Carole C Perry
Over the past decade, significant progress has been made in the identification of novel material binding peptides having affinity to a wide range of target materials and their use in nanobiotechnological innovations. These material binding peptides (MBPs), also known as solid/ substance binding peptides (SBPs) can be isolated using combinatorial display technologies such as phage display (PD), surface display (cell, bacterial, yeast, mRNA) exhibit material specific selectivity and affinity towards a range of inorganic and organic nanomaterial surfaces including metals, metal oxides, minerals, semiconductors and biomolecules...
December 1, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27906513/smartphone-based-portable-wireless-optical-system-for-the-detection-of-target-analytes
#6
Shreedhar Gautam, Bhagwan S Batule, Hyo Yong Kim, Ki Soo Park, Hyun Gyu Park
Rapid and accurate on-site wireless measurement of hazardous molecules or biomarkers is one of the biggest challenges in nanobiotechnology. We herein describe a novel smartphone-based Portable and Wireless Optical System (PAWS) for rapid, quantitative, and on-site analysis of target analytes. As a proof-of-concept, we employed gold nanoparticles (GNP) and an enzyme, horse radish peroxidase (HRP), to generate colorimetric signals in response to two model target molecules, melamine and hydrogen peroxide, respectively...
December 1, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27901298/biomimicry-promotes-the-efficiency-of-a-10-step-sequential-enzymatic-reaction-on-nanoparticles-converting-glucose-to-lactate
#7
Chinatsu Mukai, Lizeng Gao, Jacquelyn L Nelson, James P Lata, Roy Cohen, Lauren Wu, Meleana M Hinchman, Magnus Bergkvist, Robert W Sherwood, Sheng Zhang, Alexander J Travis
For nanobiotechnology to achieve its potential, complex organic-inorganic systems must grow to utilize the sequential functions of multiple biological components. Critical challenges exist: immobilizing enzymes can block substrate-binding sites or prohibit conformational changes, substrate composition can interfere with activity, and multistep reactions risk diffusion of intermediates. As a result, the most complex tethered reaction reported involves only 3 enzymes. Inspired by the oriented immobilization of glycolytic enzymes on the fibrous sheath of mammalian sperm, here we show a complex reaction of 10 enzymes tethered to nanoparticles...
January 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/27881055/patents-in-nanobiotechnology-a-cross-jurisdictional-approach
#8
Padmavati Manchikanti, Shailaja Gnaneshwar, B Ramesh Kumar
BACKGROUND: Bio nanomaterials create new opportunities for advancing medical sciences and diseases treatment in relation to human health care. Innovations in the use of such nanomaterials and nanodevices can lead to significant improvements in the use of drugs/devices. OBJECTIVE: The present study attempts to analyse patenting trends in different areas and compare the patentability criteria and the disclosure norms for nanobiotechnology inventions in countries such as US, EU and India in the field of diagnostics and therapeutics...
November 22, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27797224/glutaraldehyde-mediated-synthesis-of-asparaginase-bound-maghemite-nanocomposites-cytotoxicity-against-human-colon-adenocarcinoma-cells
#9
G Baskar, Garrick Bikku George
Drugs processed using nanobiotechnology may be more biocompatible, with sustainable and stabilised release or action. L-asparaginase produced from fungi has many advantages for treatment of lymphocytic leukemia with lesser side effect. In the present work, maghemite nanobiocomposites of fungal asparaginase were produced using glutaraldehyde-pretreated colloidal magnetic nanoparticles. Formation of nanobiocomposites was observed using laser light scattering and confirmed by UV-visible spectrophotometry with the absorption peak at 497 nm...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27796511/neuromolecular-imaging-a-nanobiotechnology-for-parkinson-s-disease-advancing-pharmacotherapy-for-personalized-medicine
#10
P A Broderick, L Wenning, Y-S Li
Evaluating each patient and animal as its own control achieves personalized medicine, which honors the hippocratic philosophy, explaining that "it is far more important to know what person has the disease than what disease the person has." Similarly, individualizing molecular signaling directly from the patient's brain in real time is essential for providing prompt, patient-based treatment as dictated by the point of care. Fortunately, nanotechnology effectively treats many neurodegenerative diseases. In particular, the new medicinal frontier for the discovery of therapy for Parkinson's disease is nanotechnology and nanobiotechnology...
October 28, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27748519/specific-growth-rate-and-multiplicity-of-infection-affect-high-cell-density-fermentation-with-bacteriophage-m13-for-ssdna-production
#11
Benjamin Kick, Samantha Hensler, Florian Praetorius, Hendrik Dietz, Dirk Weuster-Botz
The bacteriophage M13 has found frequent applications in nanobiotechnology due to its chemically and genetically tunable protein surface and its ability to self-assemble into colloidal membranes. Additionally, its single-stranded (ss) genome is commonly used as scaffold for DNA origami. Despite the manifold uses of M13, upstream production methods for phage and scaffold ssDNA are underexamined with respect to future industrial usage. Here, the high-cell-density phage production with Escherichia coli as host organism was studied in respect of medium composition, infection time, multiplicity of infection and specific growth rate...
October 17, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27747859/curcumin-as-potential-therapeutic-natural-product-a-nanobiotechnological-perspective
#12
REVIEW
Soumitra Shome, Anupam Das Talukdar, Manabendra Dutta Choudhury, Mrinal Kanti Bhattacharya, Hrishikesh Upadhyaya
OBJECTIVES: Nanotechnology-based drug delivery systems can resolve the poor bioavailability issue allied with curcumin. The therapeutic potential of curcumin can be enhanced by making nanocomposite preparation of curcumin with metal oxide nanoparticles, poly lactic-co-glycolic acid (PLGA) nanoparticles and solid lipid nanoparticles that increases its bioavailability in the tissue. KEY FINDINGS: Curcumin has manifold therapeutic effects which include antidiabetic, antihypertensive, anticancer, anti-inflammatory and antimicrobial properties...
December 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27696775/laccase-a-multi-purpose-biocatalyst-at-the-forefront-of-biotechnology
#13
Diana M Mate, Miguel Alcalde
Laccases are multicopper containing enzymes capable of performing one electron oxidation of a broad range of substrates. Using molecular oxygen as the final electron acceptor, they release only water as a by-product, and as such, laccases are eco-friendly, versatile biocatalysts that have generated an enormous biotechnological interest. Indeed, this group of enzymes has been used in different industrial fields for very diverse purposes, from food additive and beverage processing to biomedical diagnosis, and as cross-linking agents for furniture construction or in the production of biofuels...
October 3, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27677514/design-of-self-assembling-protein-polymer-conjugates
#14
Nathan A Carter, Xi Geng, Tijana Z Grove
Protein-polymer conjugates are of particular interest for nanobiotechnology applications because of the various and complementary roles that each component may play in composite hybrid-materials. This chapter focuses on the design principles and applications of self-assembling protein-polymer conjugate materials. We address the general design methodology, from both synthetic and genetic perspective, conjugation strategies, protein vs. polymer driven self-assembly and finally, emerging applications for conjugate materials...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27648483/an-enteric-micromotor-can-selectively-position-and-spontaneously-propel-in-the-gastrointestinal-tract
#15
Jinxing Li, Soracha Thamphiwatana, Wenjuan Liu, Berta Esteban-Fernández de Ávila, Pavimol Angsantikul, Elodie Sandraz, Jianxing Wang, Tailin Xu, Fernando Soto, Valentin Ramez, Xiaolei Wang, Weiwei Gao, Liangfang Zhang, Joseph Wang
The gastrointestinal (GI) tract, which hosts hundreds of bacteria species, becomes the most exciting organ for the emerging microbiome research. Some of these GI microbes are hostile and cause a variety of diseases. These bacteria colonize in different segments of the GI tract dependent on the local physicochemical and biological factors. Therefore, selectively locating therapeutic or imaging agents to specific GI segments is of significant importance for studying gut microbiome and treating various GI-related diseases...
September 20, 2016: ACS Nano
https://www.readbyqxmd.com/read/27633935/gold-nanocrystals-with-dna-directed-morphologies
#16
Xingyi Ma, June Huh, Wounjhang Park, Luke P Lee, Young Jik Kwon, Sang Jun Sim
Precise control over the structure of metal nanomaterials is important for developing advanced nanobiotechnology. Assembly methods of nanoparticles into structured blocks have been widely demonstrated recently. However, synthesis of nanocrystals with controlled, three-dimensional structures remains challenging. Here we show a directed crystallization of gold by a single DNA molecular regulator in a sequence-independent manner and its applications in three-dimensional topological controls of crystalline nanostructures...
September 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27614818/multifunctional-gold-based-nanocomposites-for-theranostics
#17
REVIEW
Lev A Dykman, Nikolai G Khlebtsov
Although Au-particle potential in nanobiotechnology has been recognized for the last 15 years, new insights into the unique properties of multifunctional nanostructures have just recently started to emerge. Multifunctional gold-based nanocomposites combine multiple modalities to improve the efficacy of the therapeutic and diagnostic treatment of cancer and other socially significant diseases. This review is focused on multifunctional gold-based theranostic nanocomposites, which can be fabricated by three main routes...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27600262/heal-fuel-and-feed-the-world-advances-in-nanobiotechnology
#18
EDITORIAL
Guang-Hui Ma, Dan Wang
No abstract text is available yet for this article.
September 2016: Small
https://www.readbyqxmd.com/read/27554277/ultrasonic-assisted-green-synthesis-of-flower-like-silver-nanocolloids-using-marine-sponge-extract-and-its-effect-on-oral-biofilm-bacteria-and-oral-cancer-cell-lines
#19
D Inbakandan, C Kumar, M Bavanilatha, Dune Naga Ravindra, R Kirubagaran, S Ajmal Khan
The knowhow followed for synthesis, characterization and application of nanomaterials has become an important branch of nanoscience. The use of marine sponges for the synthesis of metal nanoparticles is still in the budding level of current nanobiotechnology. This paper reports a single step one pot biosynthesis utilizing marine sponge (Haliclona exigua) extract as a reducing agent by means of a conventional ultrasonic bath on the formation and growth of flower like silver nanocolloids. These silver nanocolloids were characterized through UV visible spectroscopy, High Resolution Transmission Electron Microscope, Fourier Transform Infrared spectroscopy and X-ray Diffractometer...
October 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27550384/site-specific-control-of-multiple-mineralizations-using-a-designed-peptide-and-dna
#20
Kenji Usui, Makoto Ozaki, Aoi Yamada, Yoshio Hamada, Takaaki Tsuruoka, Takahito Imai, Kin-Ya Tomizaki
We have developed a site-specific method for precipitating multiple inorganic compounds using target DNA and a designed peptide consisting of a peptide nucleic acid (PNA) sequence and an inorganic compound-precipitating sequence. This system for controlled site-specific precipitation represents a powerful tool for use in nanobiotechnology and materials science.
October 21, 2016: Nanoscale
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