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Nanobiotechnology

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https://www.readbyqxmd.com/read/29144399/dna-g-wire-formation-using-an-artificial-peptide-is-controlled-by-protease-activity
#1
Kenji Usui, Arisa Okada, Shungo Sakashita, Masayuki Shimooka, Takaaki Tsuruoka, Shu-Ichi Nakano, Daisuke Miyoshi, Tsukasa Mashima, Masato Katahira, Yoshio Hamada
The development of a switching system for guanine nanowire (G-wire) formation by external signals is important for nanobiotechnological applications. Here, we demonstrate a DNA nanostructural switch (G-wire <--> particles) using a designed peptide and a protease. The peptide consists of a PNA sequence for inducing DNA to form DNA-PNA hybrid G-quadruplex structures, and a protease substrate sequence acting as a switching module that is dependent on the activity of a particular protease. Micro-scale analyses via TEM and AFM showed that G-rich DNA alone forms G-wires in the presence of Ca(2+), and that the peptide disrupted this formation, resulting in the formation of particles...
November 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29131585/antibody-templated-assembly-of-an-rna-mimic-of-green-fluorescent-protein
#2
Alessandro Bertucci, Alessandro Porchetta, Francesco Ricci
One of the most intriguing ways through which Nature achieves regulation of biological pathways encompasses the coordination of non-covalent interactions that bring biomolecules to be co-localized in a designated restricted space. This nano-confinement leads to a drastic increase in the effective local concentration of the species involved, which ultimately triggers reactions that would otherwise not occur at the low concentrations found in cells. Inspired by this mechanism, we have explored the possibility of using antibodies as bivalent biomolecular substrates for the templated assembly of a functional RNA structure...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29117680/molecular-determinants-and-bottlenecks-in-the-dissociation-dynamics-of-biotin-streptavidin
#3
Pratyush Tiwary
Biotin-streptavidin is a very popular system used to gain insight into protein-ligand interactions. In its tetrameric form, it is well-known for its exceptionally high kinetic stability, being one of the strongest known non-covalent interactions in nature, and is heavily used across the biotechnological industry. In this work we gain understanding of the molecular determinants and bottlenecks in the dissociation of the dimeric biotin-streptavidin system in wild type and with a point mutation. Using new enhanced sampling methods with full atomistic resolution, we reproduce the experimentally reported effect of the mutation on the dissociation rate...
November 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29081048/solid-binding-peptides-in-biomedicine
#4
Andrew Care, Peter L Bergquist, Anwar Sunna
Some peptides are able to bind to inorganic materials such as silica and gold. Over the past decade, Solid-binding peptides (SBPs) have been used increasingly as molecular building blocks in nanobiotechnology. These peptides show selectivity and bind with high affinity to a diverse range of inorganic surfaces e.g. metals, metal oxides, metal compounds, magnetic materials, semiconductors, carbon materials, polymers and minerals. They can be used in applications such as protein purification and synthesis, assembly and the functionalization of nanomaterials...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29043857/magnetic-carbon-nanotubes-preparation-physical-properties-and-applications-in-biomedicine
#5
Mehrdad Samadishadlou, Masoud Farshbaf, Nasim Annabi, Taras Kavetskyy, Rovshan Khalilov, Siamak Saghfi, Abolfazl Akbarzadeh, Sepideh Mousavi
Magnetic carbon nanotubes (MCNTs) have been widely studied for their potential applications in medicine, diagnosis, cell biology, analytical chemistry, and environmental technology. Introduction of MCNTs paved the way for the emergence of new approaches in nanobiotechnology and biomedicine as a result of their multifarious properties embedded within either the carbon nanotubes (CNTs) or magnetic parts. Numerous preparation techniques exists for functionalizing CNTs with magnetic nanoparticles, and these versatile strategies lay the ground for the generation of novel and versatile systems which are applicable to many industries and biological areas...
October 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29025665/cell-attachment-evaluation-of-the-immobilized-bioactive-peptide-on-a-nanographene-oxide-composite
#6
Behzad Adibi-Motlagh, Abbas Sahebghadam Lotfi, Aram Rezaei, Ehsan Hashemi
The immobilization of bioactive peptides as key molecules in numerous biological and physiological functions holds promise for designing advanced biomaterials. Graphene and its derivatives, having unique physicochemical properties, have brought considerable attention in the life sciences. In this regard, the chemical manipulation of the graphene surface with bioactive peptides opens a new horizon to design bioactive materials for a variety of future nanobiotechnologies. In this study, the first straightforward strategy for the covalent immobilization of the cell-adhesion peptide onto the graphene surface based on the Ugi four-component assembly process (Ugi 4-CAP) will be presented...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28965140/fungi-assisted-silver-nanoparticle-synthesis-and-their-applications
#7
REVIEW
Azhar U Khan, Nazia Malik, Masudulla Khan, Moo Hwan Cho, Mohammad Mansoob Khan
Nanotechnology is a rapidly developing field because of its wide range of applications in science, nanoscience and biotechnology. Nanobiotechnology deals with nanomaterials synthesised or modified using biotechnology. Fungi are used to synthesise metal nanoparticles and they have vast applications in wound healing, pathogen detection and control, food preservation, textiles, fabrics, etc. The present review describes the different types of fungi used for the biosyntheses of silver nanoparticles (AgNPs), along with their characterisation and possible biological applications...
September 30, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28952430/gold-nanoparticles-promising-agent-to-improve-the-diagnosis-and-therapy-of-cancer
#8
Limin Ning, Benwei Zhu, Tao Gao
BACKGROUND: Gold nanoparticles have been exploited for nanobiotechnology applications for the last two decades. New insights of the nanomaterials as promising agent for cancer diagnosis and therapy have just started to emerge. Due to the size- and shape-dependent optical, electrical and thermal properties, gold nanoparticles are being developed as diagnostic reagents, drug carriers, contrast agents, photothermal agents and radiosensitisers. OBJECTIVE: This review aims to summarize the latest advances of gold nanoparticles in cancer treatment...
September 25, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28926036/polymer-nanodiscs-and-macro-nanodiscs-of-a-varying-lipid-composition
#9
Venkata Sudheer Kumar Ramadugu, Giacomo Maria Di Mauro, Thirupathi Ravula, Ayyalusamy Ramamoorthy
Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to ∼60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties.
September 28, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28920693/ph-tunable-and-divalent-metal-ion-tolerant-polymer-lipid-nanodiscs
#10
Thirupathi Ravula, Nathaniel Z Hardin, Sudheer Kumar Ramadugu, Ayyalusamy Ramamoorthy
The development and applications of detergent-free membrane mimetics have been the focus for the high-resolution structural and functional studies on membrane proteins. The introduction of lipid nanodiscs has attracted new attention toward the structural biology of membrane proteins and also enabled biomedical applications. Lipid nanodiscs provide a native lipid bilayer environment similar to the cell membrane surrounded by a belt made up of proteins or peptides. Recent studies have shown that the hydrolyzed form of styrene maleic anhydride copolymer (SMA) has the ability to form lipid nanodiscs and has several advantages over protein or peptide based nanodiscs...
September 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28919741/extracellular-biosynthesis-of-silver-nanoparticles-using-the-cell-free-filtrate-of-nematophagous-fungus-duddingtonia-flagrans
#11
Laryssa Pinheiro Costa Silva, Jairo Pinto Oliveira, Wanderson Juvencio Keijok, André Romero da Silva, Anderson Rocha Aguiar, Marco Cesar Cunegundes Guimarães, Carolina Magri Ferraz, Jackson Victor Araújo, Fernando Luiz Tobias, Fábio Ribeiro Braga
The biosynthesis of metallic nanoparticles (NPs) using biological systems such as fungi has evolved to become an important area of nanobiotechnology. Herein, we report for the first time the extracellular synthesis of highly stable silver NPs (AgNPs) using the nematophagous fungus Duddingtonia flagrans (AC001). The fungal cell-free filtrate was analyzed by the Bradford method and 3,5-dinitrosalicylic acid assay and used to synthesize the AgNPs in the presence of a 1 mM AgNO3 solution. They have been characterized by UV-Vis spectroscopy, X-ray diffraction, transmission electron microscopy, dynamic light scattering, Zeta potential measurements, Fourier-transform infrared, and Raman spectroscopes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28900776/haloarchaea-worth-exploring-for-their-biotechnological-potential
#12
REVIEW
Aparna Singh, Anil K Singh
Halophilic archaea are unique microorganisms adapted to survive under high salt conditions and biomolecules produced by them may possess unusual properties. Haloarchaeal metabolites are stable at high salt and temperature conditions that are useful for industrial applications. Proteins and enzymes of this group of archaea are functional under salt concentrations at which bacterial counterparts fail to be active. Such properties makes haloarchaeal enzymes suitable for salt-based applications and their use under dehydrating conditions...
September 12, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28898880/personalized-management-of-cardiovascular-disorders
#13
Kewal K Jain
Personalized management of cardiovascular disorders (CVDs), also referred to as personalized or precision cardiology in accordance with general principles of personalized medicine, is the selection of best treatment for an individual patient. It involves the integration of various 'omics' technologies such as genomics and proteomics as well as other new technologies such as nanobiotechnology. Molecular diagnostics and biomarkers are important for linking diagnosis with therapy and monitoring of therapy. Because CVDs involve perturbations of large complex biological networks, a systems biology approach to CVD risk stratification may be used for improving risk-estimating algorithms and modeling of personalized benefit-of-treatment may be helpful for guiding choice of intervention...
September 11, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28873280/a-biomimetic-escape-strategy-for-cytoplasm-invasion-by-synthetic-particles
#14
Nerea Iturrioz-Rodríguez, Elena González-Domínguez, Eloisa González-Lavado, Laura Marín-Caba, Belén Vaz, Moisés Pérez-Lorenzo, Miguel A Correa-Duarte, Monica L Fanarraga
The translocation of nanomaterials or complex delivery systems into the cytosol is a major challenge in nanobiotechnology. After receptor-mediated endocytosis, most nanomaterials are sequestered and undergo degradation, therapy inactivation, or exocytosis. Herein we explore a novel surface particle coating made of adsorbed carbon nanotubes that provides coated materials with new properties that reproduce the viral cell-invasive mechanisms, namely, receptor-mediated endocytosis, endolysosomal escape, and cytosolic particle release preserving cell viability...
September 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28857275/size-of-single-wall-carbon-nanotube-affects-the-folate-receptor-mediated-cancer-cell-targeting
#15
Fahimeh Charbgoo, Mehrdad Behmanesh, Maryam Nikkhah
Advances in nanobiotechnology and targeting strategy could improve the delivery of therapeutic molecules into cancer cells, leading to improved treatment efficiency with minimal side effects on normal cells. To design an efficient nanocarrier, consideration of parameters that facilitate direct drug delivery into the target cells is important. We studied the effect of single wall carbon nanotubes size on their cell internalization level via the folate receptor-mediated pathway through folic acid targeting. Folate-SWNTs were covalently synthesized and characterized...
August 30, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28853474/molecular-simulations-of-peptide-amphiphiles
#16
REVIEW
Anjela Manandhar, Myungshim Kang, Kaushik Chakraborty, Phu K Tang, Sharon M Loverde
This review describes recent progress in the area of molecular simulations of peptide assemblies, including peptide-amphiphiles and drug-amphiphiles. The ability to predict the structure and stability of peptide self-assemblies from the molecular level up is vital to the field of nanobiotechnology. Computational methods such as molecular dynamics offer the opportunity to characterize intermolecular forces between peptide-amphiphiles that are critical to the self-assembly process. Furthermore, these computational methods provide the ability to computationally probe the structure of these supramolecular assemblies at the molecular level, which is a challenge experimentally...
October 4, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28830191/electrostatic-conditions-define-the-2d-self-assembly-of-tomato-bushy-stunt-viruses-on-solid-surfaces
#17
Veronika Rink, Christine Müller-Renno, Christiane Ziegler, Mario Braun, Kajohn Boonrod, Gabriele Krczal
Plant viruses which are self-assembled on a substrate are interesting building blocks in nanobiotechnology, in particular, for the creation of 2D ordered structures. In this article, the self-assembly of different genetically modified types of the tomato bushy stunt virus spin-coated on pristine silicon was investigated by scanning force and scanning electron microscopy. Amino acid side chains were integrated in the capsids of the viruses by extending the coat protein with different charged amino acid clusters (tetra-aspartate-hexa-histidine, hexa-aspartate, or tetra-arginine-tags)...
August 22, 2017: Biointerphases
https://www.readbyqxmd.com/read/28774148/synthesis-and-structural-characterization-of-silver-nanoparticles-stabilized-with-3-mercapto-1-propansulfonate-and-1-thioglucose-mixed-thiols-for-antibacterial-applications
#18
Francesco Porcaro, Laura Carlini, Andrea Ugolini, Daniela Visaggio, Paolo Visca, Ilaria Fratoddi, Iole Venditti, Carlo Meneghini, Laura Simonelli, Carlo Marini, Wojciech Olszewski, Nitya Ramanan, Igor Luisetto, Chiara Battocchio
The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3MPS) and 1-β-thio-d-glucose (TG). The investigation of the structural and electronic properties of the nano-systems was carried out by means of X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS)...
December 20, 2016: Materials
https://www.readbyqxmd.com/read/28751252/pore-forming-toxins-in-cnidaria
#19
REVIEW
Marjetka Podobnik, Gregor Anderluh
The ancient phylum of Cnidaria contains many aquatic species with peculiar lifestyle. In order to survive, these organisms have evolved attack and defense mechanisms that are enabled by specialized cells and highly developed venoms. Pore-forming toxins are an important part of their venomous arsenal. Along some other types, the most representative are examples of four protein families that are commonly found in other kingdoms of life: actinoporins, Cry-like proteins, aerolysin-like toxins and MACPF/CDC toxins...
July 24, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28747089/advances-in-nanopore-sensing-promises-to-transform-healthcare
#20
Farzin Haque, Shaoying Wang, Taoxiang Wu, Peixuan Guo
International Conference on Nanopore Technology (Shenzhen), 30 March-1 April 2017, Shenzhen, China The International Conference on Nanopore Technology (Shenzhen) was held from 30 March to 1 April 2017 in Shenzhen, China. The goal of the meeting was threefold: leverage the unique properties of nanopore technology to promote transformative advances in medicine, encourage cross-disciplinary collaborations in the research community within China and abroad; and discuss critical challenges that need to be addressed to rapidly advance the field...
July 27, 2017: Nanomedicine
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