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Nanobiotechnology

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https://www.readbyqxmd.com/read/28920693/ph-tunable-and-divalent-metal-ion-tolerant-polymer-lipid-nanodiscs
#1
Thirupathi Ravula, Nathaniel Hardin, Sudheer Ramadugu, Ayyalusamy Ramamoorthy
The development and applications of detergent-free membrane mimetics have been the focus for the high-resolution structural and functional studies on membrane proteins. The introduction of lipid nanodiscs has attracted new attention towards the structural biology of membrane proteins and also enabled biomedical applications. Lipid nanodiscs provide a native lipid bilayer environment similar to the cell membrane surrounded by a belt made up of proteins or peptides. Recent studies have shown that the hydrolyzed form of styrene maleic anhydride copolymer (SMA) has the ability to form lipid nanodiscs and has several advantages over protein or peptide based nanodiscs...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28919741/extracellular-biosynthesis-of-silver-nanoparticles-using-the-cell-free-filtrate-of-nematophagous-fungus-duddingtonia-flagrans
#2
Laryssa Pinheiro Costa Silva, Jairo Pinto Oliveira, Wanderson Juvencio Keijok, André Romero da Silva, Anderson Rocha Aguiar, Marco Cesar Cunegundes Guimarães, Carolina Magri Ferraz, Jackson Victor Araújo, Fernando Luiz Tobias, Fábio Ribeiro Braga
The biosynthesis of metallic nanoparticles (NPs) using biological systems such as fungi has evolved to become an important area of nanobiotechnology. Herein, we report for the first time the extracellular synthesis of highly stable silver NPs (AgNPs) using the nematophagous fungus Duddingtonia flagrans (AC001). The fungal cell-free filtrate was analyzed by the Bradford method and 3,5-dinitrosalicylic acid assay and used to synthesize the AgNPs in the presence of a 1 mM AgNO3 solution. They have been characterized by UV-Vis spectroscopy, X-ray diffraction, transmission electron microscopy, dynamic light scattering, Zeta potential measurements, Fourier-transform infrared, and Raman spectroscopes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28900776/haloarchaea-worth-exploring-for-their-biotechnological-potential
#3
REVIEW
Aparna Singh, Anil K Singh
Halophilic archaea are unique microorganisms adapted to survive under high salt conditions and biomolecules produced by them may possess unusual properties. Haloarchaeal metabolites are stable at high salt and temperature conditions that are useful for industrial applications. Proteins and enzymes of this group of archaea are functional under salt concentrations at which bacterial counterparts fail to be active. Such properties makes haloarchaeal enzymes suitable for salt-based applications and their use under dehydrating conditions...
September 12, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28898880/personalized-management-of-cardiovascular-disorders
#4
Kewal K Jain
Personalized management of cardiovascular disorders (CVDs), also referred to as personalized or precision cardiology in accordance with general principles of personalized medicine, is the selection of best treatment for an individual patient. It involves the integration of various 'omics' technologies such as genomics and proteomics as well as other new technologies such as nanobiotechnology. Molecular diagnostics and biomarkers are important for linking diagnosis with therapy and monitoring of therapy. Because CVDs involve perturbations of large complex biological networks, a systems biology approach to CVD risk stratification may be used for improving risk-estimating algorithms and modeling of personalized benefit-of-treatment may be helpful for guiding choice of intervention...
September 11, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28873280/a-synthetic-getaway-biomimetic-strategy-for-cytoplasm-particle-invasion
#5
Monica L Fanarraga, Nerea Iturrioz-Rodriguez, Elena González-Domínguez, Eloisa González-Lavado, Laura Marín-Caba, Belén Vaz Araújo, Moisés Pérez-Lorenzo, Miguel Correa-Duarte
The translocation of nanomaterials or complex delivery systems into the cytosol is a main challenge in nanobiotechnology. After receptor-mediated endocytosis, most nanomaterials are sequestered undergoing degradation, therapy inactivation or exocytosis. Here we explore a novel surface particle-coating made of adsorbed carbon nanotubes that provides coated materials with new properties that reproduce the viral cell invasive mechanisms, namely: receptor mediated endocytosis, endo-lysosomal escape and cytosolic particle release preserving intact cell viability...
September 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28857275/size-of-single-wall-carbon-nanotube-affects-the-folate-receptor-mediated-cancer-cell-targeting
#6
Fahimeh Charbgoo, Mehrdad Behmanesh, Maryam Nikkhah
Advances in nanobiotechnology and targeting strategy could improve the delivery of therapeutic molecules into cancer cells, leading to improved treatment efficiency with minimal side effects on normal cells. To design an efficient nanocarrier, consideration of parameters that facilitate direct drug delivery into the target cells is important. We studied the effect of single wall carbon nanotubes size on their cell internalization level via the folate receptor-mediated pathway through folic acid targeting. Folate-SWNTs were covalently synthesized and characterized...
August 30, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28853474/molecular-simulations-of-peptide-amphiphiles
#7
REVIEW
Anjela Manandhar, Myungshim Kang, Kaushik Chakraborty, Phu K Tang, Sharon M Loverde
This review describes recent progress in the area of molecular simulations of peptide assemblies, including peptide-amphiphiles and drug-amphiphiles. The ability to predict the structure and stability of peptide self-assemblies from the molecular level up is vital to the field of nanobiotechnology. Computational methods such as molecular dynamics offer the opportunity to characterize intermolecular forces between peptide-amphiphiles that are critical to the self-assembly process. Furthermore, these computational methods provide the ability to computationally probe the structure of these supramolecular assemblies at the molecular level, which is a challenge experimentally...
August 30, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28830191/electrostatic-conditions-define-the-2d-self-assembly-of-tomato-bushy-stunt-viruses-on-solid-surfaces
#8
Veronika Rink, Christine Müller-Renno, Christiane Ziegler, Mario Braun, Kajohn Boonrod, Gabriele Krczal
Plant viruses which are self-assembled on a substrate are interesting building blocks in nanobiotechnology, in particular, for the creation of 2D ordered structures. In this article, the self-assembly of different genetically modified types of the tomato bushy stunt virus spin-coated on pristine silicon was investigated by scanning force and scanning electron microscopy. Amino acid side chains were integrated in the capsids of the viruses by extending the coat protein with different charged amino acid clusters (tetra-aspartate-hexa-histidine, hexa-aspartate, or tetra-arginine-tags)...
August 22, 2017: Biointerphases
https://www.readbyqxmd.com/read/28774148/synthesis-and-structural-characterization-of-silver-nanoparticles-stabilized-with-3-mercapto-1-propansulfonate-and-1-thioglucose-mixed-thiols-for-antibacterial-applications
#9
Francesco Porcaro, Laura Carlini, Andrea Ugolini, Daniela Visaggio, Paolo Visca, Ilaria Fratoddi, Iole Venditti, Carlo Meneghini, Laura Simonelli, Carlo Marini, Wojciech Olszewski, Nitya Ramanan, Igor Luisetto, Chiara Battocchio
The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3MPS) and 1-β-thio-d-glucose (TG). The investigation of the structural and electronic properties of the nano-systems was carried out by means of X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS)...
December 20, 2016: Materials
https://www.readbyqxmd.com/read/28751252/pore-forming-toxins-in-cnidaria
#10
REVIEW
Marjetka Podobnik, Gregor Anderluh
The ancient phylum of Cnidaria contains many aquatic species with peculiar lifestyle. In order to survive, these organisms have evolved attack and defense mechanisms that are enabled by specialized cells and highly developed venoms. Pore-forming toxins are an important part of their venomous arsenal. Along some other types, the most representative are examples of four protein families that are commonly found in other kingdoms of life: actinoporins, Cry-like proteins, aerolysin-like toxins and MACPF/CDC toxins...
July 24, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28747089/advances-in-nanopore-sensing-promises-to-transform-healthcare
#11
Farzin Haque, Shaoying Wang, Taoxiang Wu, Peixuan Guo
International Conference on Nanopore Technology (Shenzhen), 30 March-1 April 2017, Shenzhen, China The International Conference on Nanopore Technology (Shenzhen) was held from 30 March to 1 April 2017 in Shenzhen, China. The goal of the meeting was threefold: leverage the unique properties of nanopore technology to promote transformative advances in medicine, encourage cross-disciplinary collaborations in the research community within China and abroad; and discuss critical challenges that need to be addressed to rapidly advance the field...
July 27, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28739445/surface-charge-dependent-separation-of-modified-and-hybrid-ferritin-in-native-page-impact-of-lysine-104
#12
Biswamaitree Subhadarshanee, Abhinav Mohanty, Manas Kumar Jagdev, Dileep Vasudevan, Rabindra K Behera
Preparation of modified and hybrid ferritin provides a great opportunity to understand the mechanisms of iron loading/unloading, protein self-assembly, size constrained nanomaterial synthesis and targeted drug delivery. However, the large size (M.W.=490kDa) has been limiting the separation of different modified and/or hybrid ferritin nanocages from each other in their intact assembled form and further characterization. Native polyacrylamide gel electrophoresis (PAGE) separates proteins on the basis of both charge and mass, while maintaining their overall native structure and activity...
July 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28738620/proteins-in-microbial-synthesis-of-selenium-nanoparticles
#13
Anna V Tugarova, Alexander A Kamnev
Biogenic formation of nano-sized particles composed of various materials (in particular, selenium) by live microorganisms is widespread in nature. This phenomenon has been increasingly attracting the attention of researchers over the last decade not only owing to a range of diverse applications of such nanoparticles (NPs) in nanobiotechnology, but also because of the specificity of methodologies and mechanisms of NPs formation related to "green synthesis". In this mini-review, recent data are discussed on the multifaceted role of proteins in the processes of microbial reduction of selenium oxyanions and the formation of Se NPs...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28715309/rise-of-the-nanorobots-advances-in-control-molecular-detection-and-nanoscale-actuation-are-bringing-us-closer-to-a-new-era-of-technology-enhanced-by-nanorobots
#14
Stanislav Tsitkov, Henry Hess
In 1988, a Scientific American article by A.K. Dewdney [1] on the work of nanotechnologist K. Eric Drexler spurred public interest in the nascent field of nanotechnology and its potential for advancing humanity into a new technological age. The article portrayed a world run by nanoscale machines that could operate in any environment (Figure 1), with uses ranging from fighting infections in the human body to building tomorrow's skyscrapers. Nearly 30 years later, these visions of the future are closer than ever...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28715014/amyloid-scaffolds-as-alternative-chlorosomes
#15
REVIEW
Rolando F Rengifo, Noel X Li, Anthony Sementilli, David G Lynn
Living systems contain remarkable functional capability built within sophisticated self-organizing frameworks. Defining the assembly codes that coordinate these systems could greatly extend nanobiotechnology. To that end, we have highlighted the self-assembling architecture of the chlorosome antenna arrays and report the emulation and extension of their features for the development of cell-compatible photoredox materials. We specifically review work on amyloid peptide scaffolds able to (1) organize light-harvesting chromophores, (2) break peptide bilayer symmetry for directional energy and electron transfer, and (3) incorporate redox active metal ions at high density for energy storage...
August 30, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28661337/living-on-the-edge-re-shaping-the-interface-of-synthetic-biology-and-nanotechnology
#16
Shang-Jung Wu, Ardemis A Boghossian
A new team of researchers at EPFL is taking an 'anti-disciplinary' approach to creating optical devices. These devices take advantage of the synergy in tuning both nano- and bio-material properties, coupling the advantages of two growing, albeit traditionally distinct, fields. With applications spanning from biosensing and microarray assays to living photovoltaics, the Laboratory of NanoBiotechnology (LNB) is uncovering an unexplored space for the next generation of chemical analytics and light-harvesting technologies...
November 30, 2016: Chimia
https://www.readbyqxmd.com/read/28650154/interrogating-detergent-desolvation-of-nanopore-forming-proteins-by-fluorescence-polarization-spectroscopy
#17
Aaron J Wolfe, Yi-Ching Hsueh, Adam R Blanden, Mohammad M Mohammad, Bach Pham, Avinash K Thakur, Stewart N Loh, Min Chen, Liviu Movileanu
Understanding how membrane proteins interact with detergents is of fundamental and practical significance in structural and chemical biology as well as in nanobiotechnology. Current methods for inspecting protein-detergent complex (PDC) interfaces require high concentrations of protein and are of low throughput. Here, we describe a scalable, spectroscopic approach that uses nanomolar protein concentrations in native solutions. This approach, which is based on steady-state fluorescence polarization (FP) spectroscopy, kinetically resolves the dissociation of detergents from membrane proteins and protein unfolding...
August 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28626557/electrostatically-driven-resonance-energy-transfer-in-cationic-biocompatible-indium-phosphide-quantum-dots
#18
Gayathri Devatha, Soumendu Roy, Anish Rao, Abhik Mallick, Sudipta Basu, Pramod P Pillai
Indium Phosphide Quantum Dots (InP QDs) have emerged as an alternative to toxic metal ion based QDs in nanobiotechnology. The ability to generate cationic surface charge, without compromising stability and biocompatibility, is essential in realizing the full potential of InP QDs in biological applications. We have addressed this challenge by developing a place exchange protocol for the preparation of cationic InP/ZnS QDs. The quaternary ammonium group provides the much required permanent positive charge and stability to InP/ZnS QDs in biofluids...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28625680/plant-made-potyvirus-like-particles-used-for-log-increasing-antibody-sensing-capacity
#19
Ivonne González-Gamboa, Pilar Manrique, Flora Sánchez, Fernando Ponz
Deployment of the elongated flexuous virions of Turnip mosaic virus (TuMV), a potyvirus, for peptide display on their external surface has been previously reported by us. Nonetheless, both in TuMV and other potyviruses some peptides hinder the ability of the virus to infect host plants. We found that a peptide derived from the human thrombin receptor (TR) inhibited TuMV infectivity. In an effort to get around this problem, TuMV virus-like particles (VLPs) were produced in plants by transient high-level expression of wild-type or recombinant coat protein (CP)...
June 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28601037/enterococcus-species-for-the-one-pot-biofabrication-of-gold-nanoparticles-characterization-and-nanobiotechnological-applications
#20
Iyabo Christianah Oladipo, Agbaje Lateef, Joseph Adetunji Elegbede, Musibau Adewuyi Azeez, Tesleem Babatunde Asafa, Taofeek Akangbe Yekeen, Akeem Akinboro, Evariste Bosco Gueguim-Kana, Lorika Selomi Beukes, Tolulope Oluyomi Oluyide, Oluwatoyin Rebecca Atanda
In the current work, cell-free extracts of four strains of non-pathogenic Enterococcus species of food origin, were studied for the green synthesis of gold nanoparticles (AuNPs), and characterized by UV-Vis absorption spectroscopy, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The AuNPs were evaluated for their Anopheles gambiae larvicidal, dye degradation, antioxidant and thrombolytic activities. The blue-black colloidal AuNPs which absorbed maximally at 549-552nm were nearly spherical in shape, and crystalline in nature with size of 8-50nm...
June 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
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