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cancer of the larynx

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https://www.readbyqxmd.com/read/28654571/radiotherapy-alone-or-with-chemotherapy-in-the-management-of-carcinoma-of-the-supraglottic-larynx-a-25-year-community-hospital-experience
#1
Amy R Rao, Daniel A Jones, Charles M Mendenhall, Syed N Rizvi, Jessica Kirwan, Christopher G Morris, Andrew Johns, William J McAfee, William M Mendenhall
OBJECTIVES: The purpose of this study was to retrospectively review outcomes for patients treated with definitive radiotherapy for carcinoma of the supraglottic larynx at a community hospital and to compare our results with the literature. MATERIALS AND METHODS: Treatment records of 46 patients with localized carcinoma of the supraglottic larynx treated from January 1987 through January 2012 were reviewed. Overall, 18 (39%) presented with stage I or II disease, whereas 28 (61%) presented with stage III to IV...
June 26, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28653453/ahns-series-do-you-know-your-guidelines-principles-of-treatment-for-glottic-cancer-a-review-of-the-national-comprehensive-cancer-network-guidelines
#2
Jessica Yesensky, Nishant Agrawal, Semirra Bayan, Elizabeth Blair, Louis Portugal, Jason Chan, David Goldenberg, Zhen Gooi
This article is a continuation of the "Do You Know Your Guidelines" series, an initiative of the American Head and Neck Society's Education Committee to increase awareness of current best practices pertaining to head and neck cancer. The National Comprehensive Cancer Network (NCCN) guidelines for primary and adjuvant treatment of cancer of the glottic larynx are reviewed here in a systematic fashion according to stage.
June 27, 2017: Head & Neck
https://www.readbyqxmd.com/read/28651556/clinical-outcomes-of-transoral-videolaryngoscopic-surgery-for-hypopharyngeal-and-supraglottic-cancer
#3
Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita, Kaoru Ogawa
BACKGROUND: Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment outcomes of TOVS remain to be validated. METHODS: Under a straight broad intraluminal view provided by combined use of a distending laryngoscope and a videolaryngoscope, we performed en bloc tumor resection via direct bimanual handling of the ready-made straight-form surgical instruments and devices...
June 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28645646/association-of-bullous-pemphigoid-with-malignancy-a-systematic-review-and-meta-analysis
#4
Lihi Atzmony, Ilit Mimouni, Ofer Reiter, Yael Anne Leshem, Omar Taha, Michael Gdalevich, Emmilia Hodak, Daniel Mimouni
BACKGROUND: Studies evaluating whether malignancy rate is increased in patients with bullous pemphigoid (BP) have reached conflicting results. OBJECTIVE: We sought to determine whether BP is associated with malignancy. METHOD: Medline, EMBASE, the Cochrane library, and reference lists of included studies were searched for comparative studies that evaluated the relationship between BP and malignancy. Data were analyzed on the basis of study design: cross-sectional, case control, and cohort...
June 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28640948/high-level-%C3%AE-iii-tubulin-overexpression-occurs-in-most-head-and-neck-cancers-but-is-unrelated-to-clinical-outcome
#5
Julie C Nienstedt, Alexander Gröbe, Till Clauditz, Ronald Simon, Adrian Muenscher, Rainald Knecht, Guido Sauter, Christoph Moebius, Marco Blessmann, Max Heiland, Christina Pflug
BACKGROUND: βIII-tubulin (TUBB3) is an isotype of microtubules, which are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, and mitosis. Overexpression of TUBB3 was found to be associated with poor prognosis and resistance to tubulin-binding drugs and in several solid tumors including head and neck squamous cell carcinomas (HNSCC). Considering the potential high importance of a prognostic biomarker in these cancers, the present study aimed to investigate the clinical relevance of immunohistochemical TUBB3 expression in HNSCC...
June 22, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28640546/treatment-at-high-volume-facilities-and-academic-centers-is-independently-associated-with-improved-survival-in-patients-with-locally-advanced-head-and-neck-cancer
#6
John M David, Allen S Ho, Michael Luu, Emi J Yoshida, Sungjin Kim, Alain C Mita, Kevin S Scher, Stephen L Shiao, Mourad Tighiouart, Zachary S Zumsteg
BACKGROUND: The treatment of head and neck cancers is complex and associated with significant morbidity, requiring multidisciplinary care and physician expertise. Thus, facility characteristics, such as clinical volume and academic status, may influence outcomes. METHODS: The current study included 46,567 patients taken from the National Cancer Data Base who were diagnosed with locally advanced invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx and were undergoing definitive radiotherapy...
June 22, 2017: Cancer
https://www.readbyqxmd.com/read/28635071/total-laryngectomy-a-new-lateral-cervical-approach
#7
Giuseppe Spriano, Giuseppe Mercante, Fabio Ferreli, Raul Pellini
Nowadays, total laryngectomy is primarily performed for advanced laryngeal cancers with involvement of the laryngeal skeleton and/or extending outside the larynx, hypo- or oropharynx. Another field of application is represented by salvage surgery following chemo-radiation therapy failure. In both these situations, laryngectomy is achieved by therapeutic or elective neck dissection(1-2) . This procedure is carried out by adopting an open trans cervical approach. This article is protected by copyright. All rights reserved...
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28633674/primary-tumor-volume-delineation-in-head-and-neck-cancer-missing-the-tip-of-the-iceberg
#8
Olgun Elicin, Dario Terribilini, Mohamed Shelan, Werner Volken, Etienne Mathier, Alan Dal Pra, Daniel M Aebersold, Michael K Fix, Peter Manser
BACKGROUND: The aim was to evaluate the geometric and corresponding dosimetric differences between two delineation strategies for head and neck tumors neighboring air cavities. METHODS: Primary gross and clinical tumor volumes (GTV and CTV) of 14 patients with oropharynx or larynx tumors were contoured using a soft tissue window (S). In a second strategy, the same volumes were contoured with an extension to include the parts which became visible on lung window (L)...
June 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28627987/computerised-tomography-and-magnetic-resonance-imaging-of-laryngeal-squamous-cell-carcinoma-a-practical-approach
#9
Francesco Agnello, Francesco Cupido, Gianvincenzo Sparacia, Federico Midiri, Martina Miroddi, Emanuele Grassedonio, Massimo Galia
Squamous cell carcinoma is the most common head and neck cancer. This review describes the state-of-the-art computerised tomography and magnetic resonance imaging protocols of the neck and the normal larynx anatomy, and provides a practical approach for the diagnosis and staging of laryngeal squamous cell carcinoma.
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28625009/modifications-in-the-treatment-of-advanced-laryngeal-cancer-throughout-the-last-30%C3%A2-years
#10
Jacinto García Lorenzo, Victoria Montoro Martínez, Antonio Rigo Quera, Alberto Codina Aroca, Montserrat López Vilas, Miquel Quer Agustí, Xavier León Vintró
In the last decades, the treatment schemes for patients with locally advanced laryngeal cancer have changed significantly. These changes may have an impact in the survival of these patients. Our objective is to review the treatments administered to patients with locally advanced larynx tumors during a period of 30 years in our institution and to evaluate the prognostic impact of the changes in treatment protocols. Retrospective analysis of a cohort of 830 consecutive patients with T3 or T4 laryngeal carcinomas diagnosed and treated between 1985 and 2014 with a minimum follow-up of 1...
June 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28624863/matched-pair-analysis-of-patients-with-advanced-hypopharyngeal-cancer-surgery-versus-concomitant-chemoradiotherapy
#11
Shigemichi Iwae, Masato Fujii, Ryuichi Hayashi, Yasuhisa Hasegawa, Takashi Fujii, Kenji Okami, Akihiro Homma, Tetsuro Onitsuka, Takakuni Kato, Takenori Ogawa, Kyoichi Terao, Nobuya Monden, Naoki Otsuki, Hiroshi Nishino, Ichiro Ota, Yasushi Fujimoto, Kazuto Matsuura, Kazuyoshi Kawabata, Hidetoshi Matsui, Koichiro Yonezawa, Ken-Ichi Nibu
BACKGROUND: The aim of this study was to compare the therapeutic outcomes of total pharyngolaryngectomy with those of concomitant chemoradiotherapy in advanced hypopharyngeal cancer. METHODS: This is a retrospective multi-institutional study. The medical records of 979 patients with hypopharyngeal cancer, who were initially treated between 2006 and 2008, were reviewed. In this study, we matched a group of total pharyngolaryngectomy patients with a second group of chemoradiotherapy patients, according to age, gender, subsite, arytenoid fixation, cartilage invasion, and N classification, and analyzed overall survival, disease-specific survival, and locoregional control rates...
June 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28623448/comparison-between-chemoselection-and-definitive-radiotherapy-in-patients-with-cervical-esophageal-squamous-cell-carcinoma
#12
Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Hidenori Suzuki, Yusuke Koide, Yujiro Fukuda, Motoo Nomura, Takeshi Kodaira, Takeshi Shimizu, Yasuhisa Hasegawa
BACKGROUD: Laryngeal preservation is an important consideration when treating cervical esophageal cancers (CECs) such as laryngeal cancer. The standard treatment for CEC allowing laryngeal preservation is chemoradiotherapy. However, in cases of laryngeal cancer, chemoselection has also been applied as a treatment strategy that promotes larynx preservation. This strategy involves assigning the appropriate radical treatment according to the primary tumor's response to induction chemotherapy...
June 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28619290/sparing-dysphagia-aspiration-related-structures-using-novel-hybrid-volumetric-modulated-arc-therapy
#13
Sitaraman BalajiSubramanian, Karunakaran Balaji, Moorthi Thirunavukarasu, Sumana Premkumar
PURPOSE: Studies using split field IMRT to spare dysphagia/aspiration related structures (DARS) have raised concern regarding dose uncertainty at matchline. This study explores the utility of hybrid VMAT in sparing the DARS and assesses matchline dose uncertainty in postoperative oral cavity cancer patients and compares it with VMAT. METHODS & MATERIALS: Ten postoperative oral cavity cancer patients were planned with h-VMAT and VMAT using the same planning CT dataset...
June 12, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28616006/the-burden-of-chronic-pain-after-major-head-and-neck-tumor-therapy
#14
Abdullah Sulieman Terkawi, Siny Tsang, Anwar S Alshehri, Dhaifallah S Mulafikh, Abdulrahman A Alghulikah, Saleh F AlDhahri
INTRODUCTION: Little is known about the burden of chronic pain after major head and neck tumors' therapy. In this study, we aimed to estimate the prevalence of chronic pain, explore the factors associated with the presence of chronic pain, and assess the consequences of chronic pain on the patients' quality of life. METHODOLOGY: This was a cross-sectional survey among patients who had completed their therapy (e.g., surgery, radiotherapy, and chemotherapy) for major head and neck (larynx, nasopharynx, oropharynx, hypopharynx, oral cavity, tongue, and sinuses) tumors after at least 3 months...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28608731/survival-outcomes-in-patients-with-t2n0m0-stage-ii-squamous-cell-carcinoma-of-the-larynx
#15
Danielle L Gainor, Emily Marchiano, Emily Bellile, Matthew E Spector, Jeremy M G Taylor, Gregory T Wolf, Norman D Hogikyan, Mark E Prince, Carol R Bradford, Avraham Eisbruch, Francis Worden, Andrew G Shuman
Objective Emerging data have demonstrated suboptimal outcomes among patients with stage II larynx cancer. Our objective is to report survival outcomes for T2N0M0 larynx cancer and to determine the cause-specific survival. Study Design Case series with planned data collection. Setting Tertiary academic center. Subjects Adults with T2N0M0 squamous cell carcinoma of the larynx treated with curative intent. Methods A head and neck cancer epidemiology database was queried for eligible subjects from 2003 to 2014...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28607897/a-comparative-study-of-pharyngeal-repair-in-two-layers-versus-three-layers-following-total-laryngectomy-in-carcinoma-of-larynx
#16
Asok K Saha, Saikat Samaddar, Avijit Choudhury, Abir Chaudhury, Nirmalya Roy
Larynx is the second most common site for cancer in the upper aerodigestive tract. One of the dreaded complications following total laryngectomy has been pharyngo cutaneous fistula (PCF). PCF merits special attention due to its significant negative impact on the recovery process. Total laryngectomy profoundly alters speech. Effective voice restoration is essential for the rehabilitation of these patients. Inadequate consensus exists as to the best technique of pharyngeal repair to decrease incidence of PCF and ensure good quality voice following total laryngectomy...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28602410/adjuvant-chemoradiation-after-surgical-resection-in-elderly-patients-with-high-risk-squamous-cell-carcinoma-of-the-head-and-neck-a-national-cancer-database-analysis
#17
Neil M Woody, Matthew C Ward, Shlomo A Koyfman, Chandana A Reddy, Jessica Geiger, Nikhil Joshi, Brian Burkey, Joseph Scharpf, Eric Lamarre, Brandon Prendes, David J Adelstein
PURPOSE: To determine the patterns of adjuvant chemoradiotherapy use in elderly patients treated with definitive surgical resection for squamous cell carcinoma of the head and neck with extracapsular extension (ECE) or positive margins and determine whether an association with overall survival (OS) exists with adjuvant concurrent chemoradiotherapy (CRT). METHODS AND MATERIALS: The National Cancer Database was queried to identify patients with SCC of the oral cavity, oropharynx, larynx, and hypopharynx who were treated with primary definitive surgery and adjuvant radiation therapy between 2004 and 2012...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28600380/cohort-profile-the-nordic-antireflux-surgery-cohort-nordasco
#18
John Maret-Ouda, Karl Wahlin, Miia Artama, Nele Brusselaers, Martti Färkkilä, Elsebeth Lynge, Fredrik Mattsson, Eero Pukkala, Pål Romundstad, Laufey Tryggvadóttir, My von Euler-Chelpin, Jesper Lagergren
PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. PARTICIPANTS: Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries)...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28596256/nccn-guidelines-insights-head-and-neck-cancers-version-2-2017
#19
David Adelstein, Maura L Gillison, David G Pfister, Sharon Spencer, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, A Dimitrios Colevas, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, William M Lydiatt, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Sue S Yom, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the head and neck (H&N), and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding the increase in human papillomavirus-associated oropharyngeal cancer and the availability of immunotherapy agents for treatment of patients with recurrent or metastatic H&N cancer...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28592347/management-of-the-thyroid-gland-during-laryngectomy
#20
S X Li, M A Polacco, B J Gosselin, L X Harrington, A J Titus, J A Paydarfar
OBJECTIVES: This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement. METHODS: A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total laryngectomy, type of thyroidectomy, incidence of gland involvement, route of spread, and positive predictors of spread were analysed and reported...
June 8, 2017: Journal of Laryngology and Otology
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