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cancer of the larynx

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https://www.readbyqxmd.com/read/28438431/phantom-to-clinic-development-of-hypofractionated-stereotactic-body-radiotherapy-for-early-stage-glottic-laryngeal-cancer
#1
Chuxiong Ding, Stephen G Chun, Baran D Sumer, Lucien A Nedzi, Ramzi E Abdulrahman, John S Yordy, Pam Lee, Brian Hrycushko, Timothy D Solberg, Chul Ahn, Robert D Timmerman, David L Schwartz
The purpose of this study was to commission and clinically test a robotic stereotactic delivery system (CyberKnife, Sunnyvale, CA) to treat early-stage glottic laryngeal cancer. We enrolled 15 patients with cTis-T2N0M0 carcinoma of the glottic larynx onto an institutional review board (IRB)-approved clinical trial. Stereotactic body radiotherapy (SBRT) plans prescribed 45 Gy/10 fractions to the involved hemilarynx. SBRT dosimetry was compared with (1) standard carotid-sparing laryngeal intensity-modulated radiation therapy (IMRT) and (2) selective hemilaryngeal IMRT...
April 21, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28435403/comparative-analysis-of-the-incidence-of-head-and-neck-cancer-in-south-eastern-poland-and-in-poland-in-the-years-1990-2012
#2
Jan Gawełko, Marek Cierpiał-Wolan, Andrzej Kawecki, Konrad Wilk, Danuta B Pięciak-Kotlarz, Damian Sikorski
AIM OF THE STUDY: To present the changes in the incidence of cancers of the head and neck organs in south-eastern Poland and in the whole country in the years 1990-2012. MATERIAL AND METHODS: A retrospective analysis the incidence of cancers of the head and neck organs in south-eastern Poland in the years 1990-2012. Statistical methods used for cancers of ICD-10 C00-C14 and C30-C32. RESULTS: For Poland, the absolute number of cases was 123,120 in the years 1990-2012...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28430523/altered-expression-of-mirnas-is-related-to-larynx-cancer-tnm-stage-and-patients-smoking-status
#3
Antoni Bruzgielewicz, Ewa Osuch-Wojcikiewicz, Kazimierz Niemczyk, Olga Sieniawska-Buccella, Mateusz Siwak, Anna Walczak, Alicja Nowak, Ireneusz Majsterek
It has been reported that microRNAs (miRNAs) are responsible for acquiring all the hallmarks of cancer cells, as well as have a significant impact on the clinical management of cancers at every stage, including prognosis, remission, relapse, and metastasis. In this study, we investigated the association of miR-29a-3p, miR-202-3p, miR-3713, miR-4768-3p, and miR-548aa expression with clinicopathologic features in patients suffering from laryngeal cancer (LC) and determined the potential role of studied miRNAs in the progression of LC...
April 21, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28428908/metastatic-squamous-cell-carcinoma-of-colon-from-esophageal-cancer
#4
Natasha Garg, Constance Stoehr, Yan Shi Zhao, Heather Rojas, Chung-Tsen Hsueh
BACKGROUND: Esophageal cancer including squamous cell carcinoma (SCC) and adenocarcinoma represents 4% of all cancers in the United States. Patients with esophageal cancer frequently present with locally advanced disease, and about 40% of patients have evidence of metastatic disease on presentation. Common sites of metastasis include liver, lung and bone. Here, we present a rare case of colonic metastasis from primary esophageal SCC. CASE PRESENTATION: A 60-year-old Caucasian male with a history of 20-pack-year cigarette smoking received surgery and adjuvant chemoradiotherapy for locally advanced SCC of larynx...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28421833/a-multidimensional-study-of-vocal-function-following-radiation-therapy-for-laryngeal-cancers
#5
Vrushali Angadi, Emily Dressler, Joseph Stemple
BACKGROUND: Radiation therapy (XRT) has proven to be an effective curative modality in the treatment of laryngeal cancers. However, XRT also has deleterious effects on vocal function. AIM: To demonstrate the multidimensional nature of deficits in vocal function as a result of radiation therapy for laryngeal cancer. STUDY DESIGN: Cohort study. METHODOLOGY: Vocal function parameters were chosen from the 5 domains of voice assessment to complete a multidimensional assessment battery...
June 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28416345/laryngeal-function-preserving-operation-for-t4a-laryngeal-cancer-with-vocal-cord-paralysis-a-case-report
#6
Yukinori Asada, Koreyuki Kurosawa, Ko Matsumoto, Takahiro Goto, Kengo Katoh, Takayuki Imai, Shigeru Saijo, Kazuto Matsuura
For locally advanced laryngeal cancers, the standard treatment of choice is chemoradiotherapy if organ function needs to be conserved. Surgical treatment with larynx preservation is conducted only for limited cases. For locally advanced laryngeal cancers such as those with vocal cord fixation and/or cricoid cartilage destruction, there is no apparent standardized organ-preserving surgery keeping the essential laryngeal functions, viz. the airway, deglutition and articulation, uncompromized. Recently, our surgical team saw a patient with T4a advanced laryngeal cancer with vocal cord fixation who aspired to maintain his laryngeal function...
April 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28409743/pet-neck-a-multicentre-randomised-phase-iii-non-inferiority-trial-comparing-a-positron-emission-tomography-computerised-tomography-guided-watch-and-wait-policy-with-planned-neck-dissection-in-the-management-of-locally-advanced-n2-n3-nodal-metastases-in-patients
#7
Hisham Mehanna, Chris C McConkey, Joy K Rahman, Wai-Lup Wong, Alison F Smith, Chris Nutting, Andrew Gj Hartley, Peter Hall, Claire Hulme, Dharmesh K Patel, Sandra Ventorin von Zeidler, Max Robinson, Bal Sanghera, Lydia Fresco, Janet A Dunn
BACKGROUND: Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence of tumour. Consequently, a significant proportion of clinicians still practise planned ND. Fludeoxyglucose positron emission tomography (PET)-computerised tomography (CT) scanning demonstrated high negative predictive values for persistent nodal disease, providing a possible alternative paradigm to ND...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28390122/orbital-apex-syndrome-affecting-head-and-neck-cancer-patients-a-case-series
#8
A-C Prado-Ribeiro, A-C Luiz, M-A Montezuma, M-P Mak, A-R Santos-Silva, T-B Brandão
BACKGROUND: Orbital apex syndrome (OAS) is a complex and uncommon disorder that typically damages multiple cranial nerves in association with optic nerve dysfunction. OAS is associated with several different pathologies, however; only a few cases have been reported in association with head and neck cancer (HNC) so far. MATERIAL AND METHODS: A case series of HNC patients diagnosed with OAS is described including clinicopathological data, image findings, and disease outcome...
April 8, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28382126/primary-concurrent-chemoradiation-in-head-and-neck-cancers-with-weekly-cisplatin-chemotherapy-analysis-of-compliance-toxicity-and-survival
#9
Muhammad Shahid Iqbal, Cheng Chaw, Josef Kovarik, Shahzeena Aslam, Aaron Jackson, John Kelly, Werner Dobrowsky, Charles Kelly
Introduction Concurrent chemoradiation is the standard of care in inoperable locally advanced squamous cell head and neck cancers. The most widely accepted schedule of concomitant cisplatin is 100mg/m(2) given on a 3 weekly basis but the optimal regime is unknown. Objective The objective of this study is to assess the tolerability, compliance, and clinical outcomes of weekly cisplatin (40mg/m(2)). Methods During the period of January 2007-December 2009, we analyzed retrospectively 122 patients with histologically proven squamous cell carcinoma of head and neck (nasopharynx, oropharynx, larynx, hypopharynx, and oral cavity) treated with definitive chemoradiation...
April 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28376866/systemic-therapy-in-the-curative-treatment-of-head-and-neck-squamous-cell-cancer-a-systematic-review
#10
REVIEW
Eric Winquist, Chika Agbassi, Brandon M Meyers, John Yoo, Kelvin K W Chan
OBJECTIVE: To review the available evidence and make recommendations regarding use of systemically administered drugs in combination or in sequence with radiation (RT) and/or surgery for cure and/or organ preservation in patients with locally advanced nonmetastatic (Stage III to IVB) squamous cell carcinoma of the head and neck (LASCCHN). METHOD: Recognizing the Meta-analysis of Chemotherapy in Head and Neck Cancer (MACH-NC) group reports have de facto guided practice since 2000, we searched for systematic reviews in the MEDLINE, EMBASE and Cochrane Database of Systematic Reviews published from January 2000 to February 2015 in reference to 4 research questions...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28374866/overexpression-of-chromatin-assembly-factor-1-p60-predicts-biological-behaviour-of-laryngeal-carcinomas
#11
M Mesolella, B Iorio, M Landi, M Cimmino, G Ilardi, M Iengo, M Mascolo
This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs)...
February 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28372104/restoring-speech-following-total-removal-of-the-larynx-by-a-learned-transformation-from-sensor-data-to-acoustics
#12
James M Gilbert, Jose A Gonzalez, Lam A Cheah, Stephen R Ell, Phil Green, Roger K Moore, Ed Holdsworth
Total removal of the larynx may be required to treat laryngeal cancer: speech is lost. This article shows that it may be possible to restore speech by sensing movement of the remaining speech articulators and use machine learning algorithms to derive a transformation to convert this sensor data into an acoustic signal. The resulting "silent speech," which may be delivered in real time, is intelligible and sounds natural. The identity of the speaker is recognisable. The sensing technique involves attaching small, unobtrusive magnets to the lips and tongue and monitoring changes in the magnetic field induced by their movement...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28369859/role-of-mucosal-high-risk-human-papillomavirus-types-in-head-and-neck-cancers-in-central-india
#13
Tarik Gheit, Devasena Anantharaman, Dana Holzinger, Laia Alemany, Sara Tous, Eric Lucas, Priya R Prabhu, Michael Pawlita, Ruediger Ridder, Susanne Rehm, Johannes Bogers, Fausto Maffini, Susanna Chiocca, Belén Lloveras, Rekha Vijay Kumar, Thara Somanathan, Silvia de Sanjosé, Xavier Castellsagué, Marc Arbyn, Paul Brennan, Rengaswamy Sankaranarayanan, Madhavan Radhakrishna Pillai, Nitin Gangane, Massimo Tommasino
Mucosal high-risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV-attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian sub-continent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV-attributable fraction in HNC (N=364) collected in a central region of India. HNC from three different anatomical subsites were included, namely oral cavity (n=252), oropharynx (n=53) and hypopharynx/larynx (n=59)...
March 29, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28369154/modeling-variables-with-a-spike-at-zero-examples-and-practical-recommendations
#14
Eva Lorenz, Carolin Jenkner, Willi Sauerbrei, Heiko Becher
In most epidemiologic studies and in clinical research generally, there are variables with a spike at zero, namely variables for which a proportion of individuals have zero exposure (e.g., never smokers) and among those exposed the variable has a continuous distribution. Different options exist for modeling such variables, such as categorization where the nonexposed form the reference group, or ignoring the spike by including the variable in the regression model with or without some transformation or modeling procedures...
April 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28367360/tissue-engineered-larynx-future-applications-in-laryngeal-cancer
#15
REVIEW
Nick J I Hamilton, Martin A Birchall
PURPOSE OF REVIEW: This article reviews the latest developments in tissue engineering for the larynx with a specific focus on the treatment of laryngeal cancer. RECENT FINDINGS: Challenges in tissue engineering a total larynx can be divided into scaffold design, methods of re-mucosalization, and how to restore laryngeal function. The literature described a range of methods to deliver a laryngeal scaffold including examples of synthetic, biomimetic, and biological scaffolds...
2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/28351570/topical-agents-for-oral-cancer-chemoprevention-a-systematic-review-of-the-literature
#16
REVIEW
Lucy Chau, Justin T Jabara, Wanda Lai, Peter F Svider, Blake M Warner, Ho-Sheng Lin, S Naweed Raza, Andrew M Fribley
OBJECTIVES/HYPOTHESIS: We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS: A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library. Data were extracted and analyzed from selected studies including study type, sample size, demographics, treatment length, response rate, follow-up time, adverse effects, and recurrence...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28342482/treatment-outcomes-in-veterans-with-hpv-positive-head-and-neck-cancer
#17
Aaron J Feinstein, Sophie G Shay, Elena Chang, Michael S Lewis, Marilene B Wang
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) caused by the human papilloma virus (HPV) has an improved prognosis relative to HPV-negative tumors. Patients with HPV-positive disease may benefit from different treatment modalities in order to optimize survival and quality of life. We sought to investigate HPV-positive HNSCC within the military veteran population, and analyze the role of treatment modality in outcomes of patients with HPV-positive and HPV-negative tumors. METHODS: Patients diagnosed with HNSCC between January 1, 2010 and December 31, 2014 at one regional veterans health center were retrospectively examined...
March 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28327089/uniform-fdg-pet-guided-gradient-dose-prescription-to-reduce-late-radiation-toxicity-upgrade-rt-study-protocol-for-a-randomized-clinical-trial-with-dose-reduction-to-the-elective-neck-in-head-and-neck-squamous-cell-carcinoma
#18
Sven van den Bosch, Tim Dijkema, Martina C Kunze-Busch, Chris H J Terhaard, Cornelis P J Raaijmakers, Patricia A H Doornaert, Frank J P Hoebers, Marije R Vergeer, Bas Kreike, Oda B Wijers, Wim J G Oyen, Johannes H A M Kaanders
BACKGROUND: In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called 'elective dose' in order to achieve control of clinically occult metastases. As a consequence of high-resolution diagnostic imaging, occult tumor volume has significantly decreased in the last decades. Since the elective dose is dependent on occult tumor volume, the currently used elective dose may be higher than necessary. Because bilateral irradiation of the neck contributes to dysphagia, xerostomia and hypothyroidism in a dose dependent way, dose de-escalation to these regions can open a window of opportunity to reduce toxicity and improve quality of life after treatment...
March 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28316084/sensitivity-and-specificity-of-antibodies-against-hpv16-e6-and-other-early-proteins-for-the-detection-of-hpv16-driven-oropharyngeal-squamous-cell-carcinoma
#19
Dana Holzinger, Gunnar Wichmann, Lorena Baboci, Angelika Michel, Daniela Höfler, Manuel Wiesenfarth, Lea Schroeder, Paolo Boscolo-Rizzo, Christel Herold-Mende, Gerhard Dyckhoff, Andreas Boehm, Annarosa Del Mistro, Franz X Bosch, Andreas Dietz, Michael Pawlita, Tim Waterboer
To determine the sensitivity and specificity of HPV16 serology as diagnostic marker for HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), 214 HNSCC patients from Germany and Italy with fresh-frozen tumor tissues and sera collected before treatment were included in this study. Hundred and twenty cancer cases were from the oropharynx and 94 were from head and neck cancer regions outside the oropharynx (45 oral cavity, 12 hypopharynx and 35 larynx). Serum antibodies to early (E1, E2, E6 and E7) and late (L1) HPV16 proteins were analyzed by multiplex serology and were compared to tumor HPV RNA status as the gold standard...
March 18, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28315206/otorhinolaryngological-toxicities-of-new-drugs-in-oncology
#20
REVIEW
Dana M Hartl, Daphné Morel, Erika Saavedra, Christophe Massard, Alessandra Rinaldo, Nabil F Saba, Alfio Ferlito, Jean-Charles Soria
Many new or relatively new cancer drugs-personalized anticancer agents-have been approved for use in various clinical settings in oncology or are still under evaluation in clinical trials. Targeted therapies as well as new immune checkpoint blockers have toxicity profiles that differ from conventional cytotoxic chemotherapy, and many can cause adverse effects that affect the mouth and pharynx, the nasal cavities, and the larynx. This review aims to provide an overview of current knowledge concerning these side effects and contemporary management...
March 17, 2017: Advances in Therapy
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