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https://www.readbyqxmd.com/read/28079429/association-between-late-effects-assessed-by-physicians-and-quality-of-life-reported-by-head-and-neck-cancer-survivors
#1
Rikke Daugaard, Trille Kjaer, Christoffer Johansen, Jane Christiansen, Elo Andersen, Anni L Nielsen, Susanne O Dalton
BACKGROUND: Many survivors of head-and-neck cancer (HNC) suffer from late effects. Their overall quality of life deteriorates during treatment, followed by a slow recovery up to five years after treatment. We examined the association between the severity of physician-assessed late effects and the health-related quality of life (HRQoL) reported by survivors of HNC. MATERIAL AND METHODS: The analysis was based on data collected during follow-up for 136 survivors of cancer in the oral cavity, pharynx, larynx, or salivary glands...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28064382/early-assessment-of-feasibility-and-technical-specificities-of-transoral-robotic-surgery-using-the-da-vinci-xi
#2
Philippe Gorphe, Jean Von Tan, Sophie El Bedoui, Dana M Hartl, Anne Auperin, Quentin Qassemyar, Antoine Moya-Plana, François Janot, Morbize Julieron, Stephane Temam
The latest generation Da Vinci(®) Xi™ Surgical System Robot released has not been evaluated to date in transoral surgery for head and neck cancers. We report here the 1-year results of a non-randomized phase II multicentric prospective trial aimed at assessing its feasibility and technical specificities. Our primary objective was to evaluate the feasibility of transoral robotic surgery using the da Vinci(®) Xi™ Surgical System Robot. The secondary objective was to assess peroperative outcomes. Twenty-seven patients, mean age 62...
January 7, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28048821/mo-g-201-02-comparing-sample-size-requirements-for-knowledge-based-treatment-planning
#3
J J Boutilier, A D C Babier, T Craig, A L McNiven, M B Sharpe, T C Y Chan
PURPOSE: To compare how training set size affects the accuracy of a knowledge-based planning (KBP) model applied to prostate and head and neck (HN) cancer. METHODS: We selected a KBP model from the literature that uses distance-to-target histograms and organ volumes to predict an achievable dose-volume-histogram (DVH) curve for each organ-at-risk (OAR). We trained both the prostate and HN model using training set sizes of n=10, 20, 30, 50,75, and 100. We set aside 100 randomly selected treatment plans from each of the two respective cohorts of 218 to serve as a validation set for all experiments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048681/mo-fg-campus-tep2-02-first-experiences-and-perspectives-in-using-direct-multicriteria-optimization-mco-on-volumetric-modulated-arc-therapy-vmat-for-head-and-neck-cancer
#4
Samantha Edgington, Christopher Cotter, Paul Busse, Bruce Crawford, Yi Wang
PURPOSE: To report the first experiences and perspectives in using direct multicriteria optimization (MCO) on volumetric-modulated arc therapy (VMAT) for head and neck (H&N) cancer. METHODS: Ten prior patients with tumors in representative H&N regions were selected to evaluate direct MCO-VMAT in RayStation v5.0 beta. The patients were previously treated by intensity-modulated radiation therapy (IMRT) with MCO on an Elekta linear accelerator with Agility multileaf collimator...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048275/su-f-j-168-dosimetric-impact-of-mr-image-distortion-in-treatment-planning
#5
Y Yan, J Yang, S Beddar, G Ibbott, P Balter, R Kudchadker, S Krishnan, C Fuller, J Wang
PURPOSE: To evaluate the dosimetric impact of MR image distortion in treatment planning. METHODS: Based on the realistic MRI distortion measurement data from an integrated MRI-Linac system, we created a generalized distortion model and applied it to CT images to simulate distorted MRI images. Ten patients with IMRT plans generated in Pinnacle treatment planning system in 5 anatomical cancer sites (lung, prostate, spinal cord, liver, and pancreas) were retrospectively selected for the simulation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047821/su-f-t-523-radiobiological-comparison-of-helical-tomotherapy-and-vmat-in-the-treatment-of-head-and-neck-tumors
#6
R Woods, P Mavroidis, M Lehman-Davis, M Kostich, T Cook, B Chera, S Das, J Lian
PURPOSE: This study aims at comparing the efficacy of Helical Tomotherapy (TOMO) and Volumetric Modulated Arc Therapy (VMAT) in producing highly conformal dose distributions in challenging head & neck cancer patients. Furthermore, to interpret the dosimetric findings into expected tissue response rates in order to estimate their clinical impact. METHODS: Seven patients were studied and for each patient two treatment plans (one TOMO and one VMAT) were created. Structures used for optimization were: high risk PTV, standard risk PTV, brainstem, spinal cord, parotid gland, larynx, mandible and surrounding tissue...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047807/su-d-brb-02-combining-a-commercial-autoplanning-engine-with-database-dose-predictions-to-further-improve-plan-quality
#7
S P Robertson, J A Moore, X Hui, T L DeWeese, P Tran, H Quon, Z Cheng, K Bzdusek, P Kumar, T R McNutt
PURPOSE: Database dose predictions and a commercial autoplanning engine both improve treatment plan quality in different but complimentary ways. The combination of these planning techniques is hypothesized to further improve plan quality. METHODS: Four treatment plans were generated for each of 10 head and neck (HN) and 10 prostate cancer patients, including Plan_A: traditional IMRT optimization using clinically relevant default objectives; Plan_B: traditional IMRT optimization using database dose predictions; Plan_C: autoplanning using default objectives; and Plan_D: autoplanning using database dose predictions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047669/we-h-brc-07-validation-of-a-commercial-atlas-based-auto-segmentation-package-for-automated-contour-quality-control
#8
S Berry, K Jedruszczuk, H Veeraraghavan, A Apte, Z Saleh, M Hunt
PURPOSE: To investigate whether a commercial atlas based auto-segmentation (ABAS) package can be used for automated review and quality control (QC) of physician segmentations, and if so, to determine action levels for future clinical implementation. METHODS: 42 head and neck cancer (HNC) patient plan CT scans with manually defined expert physician organ at risk (OAR) segmentations were retrospectively identified. Five representative patients were selected as ABAS models and were subsequently applied to each of the remaining 37 studies, resulting in 5 auto-segmentations (AS) per patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047509/su-f-j-199-predictive-models-for-cone-beam-ct-based-online-verification-of-pencil-beam-scanning-proton-therapy
#9
L Yin, G Janssens, A Lin, P Ahn, T Solberg, J McDonough, B Teo
PURPOSE: To utilize online CBCT scans to develop models for predicting DVH metrics in proton therapy of head and neck tumors. METHODS: Nine patients with locally advanced oropharyngeal cancer were retrospectively selected in this study. Deformable image registration was applied to the simulation CT, target volumes, and organs at risk (OARs) contours onto each weekly CBCT scan. Intensity modulated proton therapy (IMPT) treatment plans were created on the simulation CT and forward calculated onto each corrected CBCT scan...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047351/su-f-j-13-choosing-an-imrt-technique-in-the-treatment-of-head-and-neck-cancer-with-daily-localization-uncertainties
#10
T Lin, L Wang, T Galloway, C Ma
PURPOSE: Head and Neck cancer treatment with IMRT/VMAT has two choices: split-filed IMRT(SFI), in which the LAN is treated with a separate anterior field and the extended whole-field IMRT(WFI) in which LAN is included with the IMRT/VMAT field. This study shows that under the same dose limit criteria, choosing the technique becomes a critical issue if daily localization and immobilization altered the dose distribution. METHODS: Nine common head-and-neck cancer cases were chosen to illustrate how the daily localization and immobilization uncertainties affect to choose between SFI and WFI...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047319/su-f-t-303-quantification-of-mlc-positioning-accuracy-in-vmat-delivery-of-head-and-neck-cancer-treatment
#11
X Li, F Yang
PURPOSE: Knowing MLC leaf positioning error over the course of treatment would be valuable for treatment planning, QA design, and patient safety. The objective of the current study was to quantify the MLC positioning accuracy for VMAT delivery of head and neck treatment plans. METHODS: A total of 837 MLC log files were collected from 14 head and neck cancer patients undergoing full arc VMAT treatment on one Varian Trilogy machine. The actual and planned leaf gaps were extracted from the retrieved MLC log files...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047305/su-f-t-224-importance-of-timely-review-of-daily-cone-beam-cts-dosimetric-evaluation-of-rejected-cbcts-for-head-and-neck-patients
#12
M Andrews, S Lin, N Yu, N Joshi, S Koyfman, P Xia
PURPOSE: To dosimetrically evaluate the importance of timely reviewing daily CBCTs for patients with head and neck cancer. METHODS: After each fraction daily cone-beam CT (CBCT) for head and neck patients are reviewed by physicians prior to next treatment. Physician rejected image registrations of CBCT were identified and analyzed for 17 patients. These CBCT images were rigidly fused with planning CT images and the contours from the planning CT were transferred to CBCTs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047110/su-c-202-05-pilot-study-of-online-treatment-evaluation-and-adaptive-re-planning-for-laryngeal-sbrt
#13
W Mao, C Liu, H Zhong, T Rozario, W Lu, X Gu, Y Yan, X Jia, B Sumer, D Schwartz
PURPOSE: We have instigated a phase I trial of 5-fraction stereotactic body radiotherapy (SBRT) for advanced-stage laryngeal cancer. We conducted this pilot dosimetric study to confirm the potential utility of online adaptive re-planning to preserve treatment quality. METHODS: Ten cases of larynx cancer were evaluated. Baseline and daily SBRT treatment plans were generated per trial protocol. Daily volumetric images were acquired prior to every fraction of treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046761/mo-g-201-01-a-multi-institutional-study-investigating-the-performance-of-a-knowledge-based-planning-system-against-pinnacle-auto-planning-engine-in-sib-imrt-for-the-head-and-neck-cancer
#14
B Wu, M Kusters, M Kunze-Busch, T Dijkema, T McNutt, G Sanguineti, D Pang
PURPOSE: Knowledge-based Planning (KBP) founded on prior planning experience and Auto-Planning Engine (APE; commercialized in Pinnacle v9.10 TPS) based on progressive optimization algorithm both aim to eliminate the trial-and-error process in radiotherapy inverse planning. This study investigates the performance of the approaches in a multi-institutional setting to evaluate their functionalities in oropharyngeal cancer and offers suggestions how they can be implemented in the clinic. METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (SIB-IMRT with two-dose-level prescription: 68 Gy to PTV68 and 50...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034680/implementation-of-intensity-modulated-radiotherapy-for-head-and-neck-cancers-in-routine-practice
#15
C Bednarek, T V F Nguyen, M Puyraveau, É Bonnet, N Lescut, C Azélie, J Miny, O Mauvais, T Maurina, F Tochet, J-F Bosset, J Thariat, X S Sun
PURPOSE: To report on patterns of relapse following implementation of intensity-modulated radiotherapy and subsequent changes in practice in a tertiary care centre. PATIENTS AND METHODS: Between 2008 and 2011, 188 consecutive patients (mean age 59 years old) received intensity-modulated radiotherapies with curative intent for squamous cell carcinomas of the oral cavity (17.5%), oropharynx (43%), hypopharynx (21%), larynx (14%), sinonasal cavities (6%), nasopharynx (1...
December 26, 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28033526/induction-chemotherapy%C3%A2-followed-by-radiotherapy-for-larynx-preservation-in-advanced-laryngeal-and-hypopharyngeal-cancer-outcome-prediction-after-one-cycle-induction-chemotherapy-by-a-score-based-on-clinical-evaluation-computed-tomography-based-volumetry%C3%A2-and
#16
Gunnar Wichmann, Anne Krüger, Andreas Boehm, Marlen Kolb, Mathias Hofer, Milos Fischer, Stefan Müller, Sandra Purz, Patrick Stumpp, Osama Sabri, Andreas Dietz, Regine Kluge
BACKGROUND: Long-term laryngectomy-free (LFS), tumour-specific (TSS) and overall survival (OS) is achieved by non-surgical larynx preservation (LP) only in a proportion of patients with locally advanced laryngeal or hypopharyngeal cancer. A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS. METHODS: Early response to IC-1 with TPF ± cetuximab was assessed in 52 patients using endoscopic tumour staging for selecting total laryngectomy for non-responders with endoscopic tumour surface shrinkage <30% versus induction chemotherapy plus radiotherapy (IC + RT) for responders...
December 26, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28028607/transoral-laser-microsurgery-for-t1b-glottic-cancer-review-of-51-cases
#17
Bernhard G Weiss, Friedrich Ihler, Yiannis Pilavakis, Hendrik A Wolff, Martin Canis, Christian Welz, Wolfgang Steiner
For the treatment of T1b glottic carcinoma, different treatment options, such as transoral laser microsurgery, open surgical techniques, and primary radiotherapy, are under discussion. In this context, the aim of the present study was to describe oncologic results and complication rates of transoral laser microsurgery in treatment of T1b glottic carcinoma. This is a retrospective unicenter chart review of patients treated at an academic tertiary referral center between 1986 and 2006. Fifty-one previously untreated T1b cases were exclusively treated by transoral laser microsurgery and included into this study, 47 were male, and 4 were female...
December 27, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28026864/complications-hospital-length-of-stay-and-readmission-after-total-laryngectomy
#18
Ryan P Goepfert, Katherine A Hutcheson, Jan S Lewin, Neha G Desai, Mark E Zafereo, Amy C Hessel, Carol M Lewis, Randal S Weber, Neil D Gross
BACKGROUND: The purpose of this study was to describe the 30-day incidence of complications after total laryngectomy (TL) in a high-volume institution and their impact on the hospital length of stay (LOS) and readmission rates. METHODS: A retrospective cohort study of all patients who underwent TL at The University of Texas MD Anderson Cancer Center from January 1, 2010 through June 30, 2013 was conducted. The patient demographics, treatment history, LOS, and 30-day post-TL complications and readmissions were extracted from the medical record...
December 27, 2016: Cancer
https://www.readbyqxmd.com/read/28026822/the-matrix-metalloproteinase-in-larynx-cancer
#19
Weronika Lucas Grzelczyk, Janusz Szemraj, Magdalena Józefowicz-Korczyńska
One of the most common carcinoma occurring in the head and neck is laryngeal cancer. Despite the rapid scientific advances in medicine the prognosis for patients with such type of disease is not satisfying. In the last few years matrix metalloproteinases ‑ MMPs and their tissue inhibitors - TIMPs, mostly MMP‑2 and MMP‑9, arouses a great interest, especially in the process of carcinogenesis. It seems that their impact in the formation and development of laryngeal cancer is significant. MMPs a group of zinc‑ and calcium‑ dependent endopeptidases play crucial role extracellular matrix collagen degradation...
December 8, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28024728/laryngeal-tumours-and-radiotherapy-dose-to-the-cricopharyngeus-are-predictive-of-death-from-aspiration-pneumonia
#20
Jolyne O'Hare, Julia Maclean, Michal Szczesniak, Rashmi Gupta, Peter Wu, Harry Quon, Ian Cook, Peter Graham
OBJECTIVES: Aspiration pneumonia is an under-reported treatment sequelae following radiotherapy for head and neck cancer (HNC) patients. This study aims to investigate its incidence and risk factors in this population. MATERIALS AND METHODS: A retrospective review of all HNC patients that had received radiotherapy or chemo radiotherapy with radical intent at a single institution was undertaken (n=206). Dose delivered to the pharyngeal constrictors, base of tongue and cricopharyngeus was calculated and compared between those patients who had died from aspiration pneumonia and those who are alive or had died from other causes...
January 2017: Oral Oncology
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