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https://www.readbyqxmd.com/read/29901735/contribution-of-chronic-conditions-to-smoking-differences-in-life-expectancy-with-and-without-disability-in-belgium
#1
Renata T C Yokota, Willma J Nusselder, Jean-Marie Robine, Jean Tafforeau, Rana Charafeddine, Lydia Gisle, Patrick Deboosere, Herman Van Oyen
Background: Smoking is the leading cause of premature mortality and morbidity. This study aimed at assessing the impact of smoking on life expectancy (LE) and LE with (LED) and without disability (DFLE). We further estimated the contribution of disability and mortality and their causes to differences in LED and DFLE by smoking. Methods: Data on disability, chronic conditions, and smoking from 17 148 participants of the 1997, 2001, 2004 Belgian Health Interview Surveys were used to estimate causes of disability using the attribution method...
June 12, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29895020/locoregional-control-and-toxicity-in-head-and-neck-carcinoma-patients-following-helical-tomotherapy-delivered-intensity-modulated-radiation-therapy-compared-with-3d-crt-data
#2
REVIEW
Olalla Santa Cruz, Pelagia Tsoutsou, Cyril Castella, Kaouthar Khanfir, Sandro Anchisi, Salim Bouayed, Oscar Matzinger, Mahmut Ozsahin
OBJECTIVES: To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS: Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, with 57% undergoing definitive and 43% postoperative radiotherapy. Primary tumour sites were oral cavity (21%), oropharynx (26%), hypopharynx (20%), larynx (22%), and others (11%)...
June 12, 2018: Oncology
https://www.readbyqxmd.com/read/29893275/evaluation-of-xrcc1-gene-polymorphism-as-a-biomarker-in-head-and-neck-cancer-patients-undergoing-chemoradiation-therapy
#3
Sambit Swarup Nanda, Ajeet Kumar Gandhi, Madhup Rastogi, Rohini Khurana, Rahat Hadi, Kamal Sahni, Surendra Prasad Mishra, Anoop K Srivastava, Madan Lal Brahma Bhatt, Devendra Parmar
PURPOSE: We evaluated the correlation of the x-ray repair cross complementing gene 1 (XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiation therapy (CCRT). METHODS AND MATERIALS: In this prospective cohort study, we included 101 patients with HNSCC (oral cavity, pharynx, and larynx) who were aged ≥ 18 years, had stage III to IVB disease, had a Karnofsky Performance Status ≥ 80, and were deemed fit for CCRT...
July 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29887186/head-and-neck-squamous-cell-carcinoma-in-people-living-with-hiv-in-france
#4
A Picard, L Arowas, L Piroth, I Heard, T Ferry
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC), mainly due to smoking, is one of the leading causes of cancer deaths. However, an increasing number of tumors - especially oropharyngeal cancer - are reported in non-smokers in association with the human papillomavirus (HPV). As HIV-infected individuals are particularly at risk of HPV-related disease, we aimed to describe the burden of HNSCC in this population. METHODS: Retrospective chart review of patients from HIV clinics diagnosed with HNSCC between 2004 and 2014...
June 7, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29884971/boerhaave-syndrome-due-to-hypopharyngeal-stenosis-associated-with-chemoradiotherapy-for-hypopharyngeal-cancer-a-case-report
#5
Hideharu Tanaka, Norihisa Uemura, Daisuke Nishikawa, Keisuke Oguri, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Byonggu An, Yasuhisa Hasegawa, Yasuhiro Shimizu
BACKGROUND: Spontaneous esophageal rupture, also known as Boerhaave syndrome, is a very serious life-threatening benign disease of the gastrointestinal tract. It is typically caused by vomiting after heavy eating and drinking. However, in our patient, because of a combination of hypopharyngeal cancer with stenosis and chemoradiotherapy (CRT), which caused chemotherapy-induced vomiting, radiotherapy-induced edema, relaxation failure, and delayed reflexes; resistance to the release of increased pressure due to vomiting was exacerbated, thus leading to Boerhaave syndrome...
June 8, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29880872/publisher-correction-dose-de-escalation-to-the-normal-larynx-using-conformal-radiotherapy-reduces-toxicity-while-maintaining-oncologic-outcome-for-t1-t2-glottic-cancer
#6
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
June 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29876189/a-novel-laryngeal-preservation-technique-following-total-glossectomy-with-hyoid-bone-resection
#7
Koreyuki Kurosawa, Takayuki Imai, Ko Matsumoto, Yukinori Asada, Kengo Katoh, Kazuto Matsuura, Takahiro Goto
Despite the recent progress of chemotherapy and sophisticated radiotherapy, surgery still remains the most reliable treatment for advanced tongue cancers in terms of survival. The major disadvantage of this treatment is that it should sacrifice the quality of patients' life. When the tongue cancer is so advanced as to involve the hyoid bone, which is considered a functional part of the larynx, radical operation needs to resect both the entire tongue and the larynx and the hyoid bone en bloc to prevent aspiration pneumonia...
April 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29869487/biological-pet-guided-adaptive-radiotherapy-for-dose-escalation-in-head-and-neck-cancer-a-systematic-review
#8
Olga Hamming-Vrieze, Arash Navran, Abrahim Al-Mamgani, Wouter V Vogel
INTRODUCTION: In recent years, the possibility of adapting radiotherapy to changes in biological tissue parameters has emerged. It is hypothesized that early identification of radio-resistant parts of the tumor during treatment provides the possibility to adjust the radiotherapy plan to improve outcome. The aim of this systematic literature review was to evaluate the current state of the art of biological PET-guided adaptive radiotherapy, focusing on dose escalation to radio-resistant tumor...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29869160/early-effects-of-irradiation-on-laryngeal-mucosa-in-a-gastroesophageal-reflux-model-an-experimental-study
#9
Süleyman Oyan, Arzu Tatlıpınar, Beste M Atasoy, Pembegül Güneş, Dilek Özbeyli, Serhan Keskin, Ayse Dağlı Değerli
OBJECTIVE: The aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradiation on laryngeal mucosa in rats. STUDY DESIGN: Animal study. SETTING: Experimental animal laboratory, tertiary referral center. SUBJECT AND METHOD: Twenty-four adult female Wistar Albino rats were grouped as: control (n = 6), reflux and irradiation (n = 10), and irradiation (n = 8). Rats were operated to create a reflux model 30 days before irradiation...
June 4, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29866601/a-phase-ii-randomized-trial-comparing-neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiotherapy-versus-concurrent-chemoradiotherapy-alone-in-advanced-squamous-cell-carcinoma-of-the-pharynx-or-larynx
#10
Pei-Wei Huang, Chien-Yu Lin, Chia-Hsun Hsieh, Cheng-Lung Hsu, Kang-Hsing Fan, Shiang-Fu Huang, Chun-Ta Liao, Shu-Kung Ng, Tzu-Chen Yen, Joseph Tung-Chieh Chang, Hung-Ming Wang
BACKGROUND: To clarify the effect of induction chemotherapy (ICT) in patients with advanced pharyngeal and laryngeal squamous cell carcinoma (PLSCC) treated with concurrent chemoradiotherapy (CCRT). METHODS: Patients with treatment-naïve nonmetastatic advanced PLSCC were stratified according to disease stage (III or IV) and resectability before being randomized to either a ICT/CCRT or CCRT arm. A cisplatin/tegafur-uracil/leucovorin regimen was administered during ICT and CCRT...
April 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29863236/a-9-year-analysis-of-transoral-laser-microsurgery-tlm-of-head-and-neck-cancer-on-their-potential-suitability-for-transoral-robotic-surgery-tors-for-estimation-of-future-tors-specific-caseload
#11
F von Scotti, M Kapsreiter, C Scherl, H Iro, C Bohr
OBJECTIVE: After that the establishment of transoral robotic surgery (TORS) for head and neck cancer has been adopted in North America, it has also recently been adopted in Europe. In these parts, transoral laser microsurgery (TLM) is widely applied. The aim of the study was to identify the absolute number of operations amenable to TORS at a TORS initiating institution on the basis of all former TLM cases. PATIENTS AND METHODS: All laser surgery procedures from May 2004 to April 2013 (108 months) were initially retrospectively registered; after that, all stage pT1 and pT2 squamous cell carcinomas of the oropharynx, hypopharynx, and larynx were selected...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29849955/association-of-tet3-epigenetic-inactivation-with-head-and-neck-cancer
#12
Kiyoshi Misawa, Atsushi Imai, Daiki Mochizuki, Masato Mima, Shiori Endo, Yuki Misawa, Takeharu Kanazawa, Hiroyuki Mineta
The aim of this study was to clarify the epigenetic regulation of ten eleven translocation protein (TET) family genes, which can provide insights into the mechanisms of tumorigenesis and the risk of disease recurrence in head and neck squamous cell carcinoma (HNSCC). We generated methylation profiles of TET1 , TET2 and TET3 genes in tumor samples obtained from 233 patients with HNSCC; these included 57 hypopharynx, 44 larynx, 69 oral cavity, and 63 oropharynx tumor samples. The mRNA expression and promoter DNA methylation of TET family genes were examined via quantitative RT-PCR and methylation-specific PCR, respectively...
May 11, 2018: Oncotarget
https://www.readbyqxmd.com/read/29844870/dietary-inflammatory-index-and-risk-of-upper-aerodigestive-tract-cancer-in-japanese-adults
#13
Makiko Abe, Nitin Shivappa, Hidemi Ito, Isao Oze, Tetsuya Abe, Yasuhiro Shimizu, Yasuhisa Hasegawa, Chikako Kiyohara, Masatoshi Nomura, Yoshihiro Ogawa, James R Hebert, Keitaro Matsuo
Background: The inflammatory potential of diet that has been shown to be associated with cancer risk. We examined the association between dietary inflammatory potential as measured by the dietary inflammatory index (DII® ) and risk of upper aerodigestive tract cancers in a Japanese case-control study. Results: A positive association was observed between increasing DII scores and overall upper aerodigestive tract cancers, and across anatomic subsites. For upper aerodigestive tract cancers, the ORQ4vsQ1 = 1...
May 8, 2018: Oncotarget
https://www.readbyqxmd.com/read/29802694/detection-of-human-papilloma-virus-and-risk-factors-among-patients-with-head-and-neck-squamous-cell-carcinoma-attending-a-tertiary-referral-centre-in-south-india
#14
Satheesh K Bandhary, Veena Shetty, Marina Saldanha, Priya Gatti, Devananda Devegowda, Pushkal S R, Avinash K Shetty
Background: Head and Neck Squamous Cell Carcinomas (HNSCC) is the sixth most common cancer globally. In India, on an average 25-30% of all cancer cases affect the head and neck. The etiological factors associated with HNSCC are tobacco, alcohol and environmental carcinogens. However there are few cases, where there are no obvious risk factors involved. In western counties, there are many reports of human papilloma virus (HPV) association with HNSCC. Hence, we conducted a study to determine the role of HPV infection and risk factors among patients with HNSCC...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29801040/association-of-human-papillomavirus-status-at-head-and-neck-carcinoma-subsites-with-overall-survival
#15
Hong Li, Sina J Torabi, Wendell G Yarbrough, Saral Mehra, Heather A Osborn, Benjamin Judson
Importance: Data are limited on the prognostic value of human papillomavirus (HPV) status for head and neck carcinoma subsites. Objective: To determine whether HPV positivity at each head and neck subsite is associated with improved overall survival. Design, Setting, and Participants: This retrospective population-based cohort study used the National Cancer Database to identify patients diagnosed with head and neck squamous cell carcinomas from January 1, 2010, to December 31, 2014...
May 10, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29798945/radical-radiotherapy-for-carcinoma-of-the-larynx-in-the-elderly-functional-and-oncological-outcomes-from-a-tertiary-cancer-care-center-in-india
#16
Narayana R Subramaniam, Vijay Kumar Srinivasalu, Deepak Balasubramanian, K U Pushpaja, Anoop Remesan Nair, Chelakkot Prameela, Krishnakumar Thankappan, Subramania Iyer
INTRODUCTION: It is estimated that around 10% of all head and neck cancer patients in India are aged over 70 years. Elderly patients are often subjected to palliative or inadequate treatment for head and neck cancers in spite of being candidates for curative intent therapy. In this study we evaluated our use of radical radiotherapy in carcinoma larynx for patients over seventy years of age to determine morbidity, likelihood of completing therapy, functional and oncological outcomes. MATERIALS AND METHODS: 132 patients of squamous cell carcinoma of the larynx treated between 2005-2015 at Amrita Institute of Medical Sciences, Kochi who were seventy years of age or older were included...
July 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29787349/head-and-neck-cancer-patients-rates-reasons-and-risk-factors-for-30-day-unplanned-readmission
#17
Michael K Ghiam, Alexander Langerman, Zoukaa Sargi, Sarah Rohde
Objective To analyze rates, risk factors, and complications for 30-day readmission among head and neck cancer (HNC) patients. Methods Retrospective review of administrative records from Vizient (Irving, Texas) Clinical Data Base/Resource Manager on HNC patients who underwent a head and neck surgical procedure from January 2013 through September 2015 at 176 academic and community medical centers. Results Of the 18,121 patients included in the study, 2502 patients were readmitted within 30 days (13.8%). Mean time to readmission was 11 ± 8...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29779202/tumour-stage-and-gender-predict-recurrence-and-second-primary-malignancies-in-head-and-neck-cancer-a-multicentre-study-within-the-inhance-consortium
#18
Emanuele Leoncini, Vladimir Vukovic, Gabriella Cadoni, Luca Giraldi, Roberta Pastorino, Dario Arzani, Livia Petrelli, Victor Wünsch-Filho, Tatiana Natasha Toporcov, Raquel Ayub Moyses, Keitaro Matsuo, Cristina Bosetti, Carlo La Vecchia, Diego Serraino, Lorenzo Simonato, Franco Merletti, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Stefania Boccia
Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium-Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52-67)...
May 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29773323/primary-laryngeal-tuberculosis-our-experiences-at-a-tertiary-care-teaching-hospital-in-eastern-india
#19
Santosh Kumar Swain, Ishwar Chandra Behera, Mahesh Chandra Sahu
INTRODUCTION: Primary laryngeal tuberculosis is a chronic bacterial infection of the larynx by Mycobacterium tuberculosis without affecting the lungs. It is a rare type of extrapulmonary tuberculosis seen in clinical practice. OBJECTIVES: This study aimed to evaluate the clinical presentation, diagnosis, and treatment of primary laryngeal tuberculosis at a tertiary care teaching hospital in eastern India. MATERIALS AND METHODS: This is a retrospective study of 11 cases of primary laryngeal tuberculosis managed between December 2013 and January 2018...
May 14, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#20
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
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